-- dump date   	20140620_061948
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
526218000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
526218000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
526218000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526218000004	Walker A motif; other site
526218000005	ATP binding site [chemical binding]; other site
526218000006	Walker B motif; other site
526218000007	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
526218000008	arginine finger; other site
526218000009	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
526218000010	DnaA box-binding interface [nucleotide binding]; other site
526218000011	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
526218000012	RNA binding surface [nucleotide binding]; other site
526218000013	Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195
526218000014	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526218000015	Walker A/P-loop; other site
526218000016	ATP binding site [chemical binding]; other site
526218000017	Q-loop/lid; other site
526218000018	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526218000019	ABC transporter signature motif; other site
526218000020	Walker B; other site
526218000021	D-loop; other site
526218000022	H-loop/switch region; other site
526218000023	Protein of unknown function (DUF721); Region: DUF721; pfam05258
526218000024	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
526218000025	Mg2+ binding site [ion binding]; other site
526218000026	G-X-G motif; other site
526218000027	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
526218000028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526218000029	Mg2+ binding site [ion binding]; other site
526218000030	G-X-G motif; other site
526218000031	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
526218000032	anchoring element; other site
526218000033	dimer interface [polypeptide binding]; other site
526218000034	ATP binding site [chemical binding]; other site
526218000035	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
526218000036	active site
526218000037	putative metal-binding site [ion binding]; other site
526218000038	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
526218000039	DNA gyrase subunit A; Validated; Region: PRK05560
526218000040	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
526218000041	CAP-like domain; other site
526218000042	active site
526218000043	primary dimer interface [polypeptide binding]; other site
526218000044	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
526218000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
526218000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
526218000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
526218000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
526218000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
526218000050	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
526218000051	active site
526218000052	metal binding site [ion binding]; metal-binding site
526218000053	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
526218000054	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
526218000055	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
526218000056	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218000057	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
526218000058	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
526218000059	putative active site [active]
526218000060	putative metal binding site [ion binding]; other site
526218000061	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
526218000062	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
526218000063	metal binding site [ion binding]; metal-binding site
526218000064	dimer interface [polypeptide binding]; other site
526218000065	Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978
526218000066	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
526218000067	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
526218000068	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
526218000069	dimer interface [polypeptide binding]; other site
526218000070	putative anticodon binding site; other site
526218000071	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
526218000072	motif 1; other site
526218000073	active site
526218000074	motif 2; other site
526218000075	motif 3; other site
526218000076	Uncharacterized conserved protein [Function unknown]; Region: COG1576
526218000077	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
526218000078	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526218000079	ATP binding site [chemical binding]; other site
526218000080	Mg2+ binding site [ion binding]; other site
526218000081	G-X-G motif; other site
526218000082	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
526218000083	ATP binding site [chemical binding]; other site
526218000084	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
526218000085	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
526218000086	Thymidylate kinase; Region: Thymidylate_kin; pfam02223
526218000087	TMP-binding site; other site
526218000088	ATP-binding site [chemical binding]; other site
526218000089	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
526218000090	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218000091	TPR motif; other site
526218000092	binding surface
526218000093	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218000094	binding surface
526218000095	TPR motif; other site
526218000096	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218000097	TPR motif; other site
526218000098	binding surface
526218000099	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218000100	binding surface
526218000101	TPR motif; other site
526218000102	TPR repeat; Region: TPR_11; pfam13414
526218000103	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218000104	binding surface
526218000105	TPR motif; other site
526218000106	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
526218000107	E3 interaction surface; other site
526218000108	lipoyl attachment site [posttranslational modification]; other site
526218000109	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
526218000110	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
526218000111	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
526218000112	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
526218000113	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
526218000114	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
526218000115	E3 interaction surface; other site
526218000116	lipoyl attachment site [posttranslational modification]; other site
526218000117	e3 binding domain; Region: E3_binding; pfam02817
526218000118	e3 binding domain; Region: E3_binding; pfam02817
526218000119	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
526218000120	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
526218000121	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
526218000122	alpha subunit interface [polypeptide binding]; other site
526218000123	TPP binding site [chemical binding]; other site
526218000124	heterodimer interface [polypeptide binding]; other site
526218000125	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
526218000126	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
526218000127	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
526218000128	tetramer interface [polypeptide binding]; other site
526218000129	TPP-binding site [chemical binding]; other site
526218000130	heterodimer interface [polypeptide binding]; other site
526218000131	phosphorylation loop region [posttranslational modification]
526218000132	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
526218000133	active site
526218000134	P-loop; other site
526218000135	phosphorylation site [posttranslational modification]
526218000136	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
526218000137	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526218000138	NAD(P) binding site [chemical binding]; other site
526218000139	active site
526218000140	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
526218000141	active site
526218000142	P-loop; other site
526218000143	phosphorylation site [posttranslational modification]
526218000144	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
526218000145	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
526218000146	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
526218000147	intersubunit interface [polypeptide binding]; other site
526218000148	active site
526218000149	Zn2+ binding site [ion binding]; other site
526218000150	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
526218000151	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
526218000152	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218000153	active site
526218000154	phosphorylation site [posttranslational modification]
526218000155	PRD domain; Region: PRD; pfam00874
526218000156	PRD domain; Region: PRD; pfam00874
526218000157	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
526218000158	active site
526218000159	P-loop; other site
526218000160	phosphorylation site [posttranslational modification]
526218000161	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359
526218000162	active site
526218000163	phosphorylation site [posttranslational modification]
526218000164	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
526218000165	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
526218000166	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
526218000167	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
526218000168	active site
526218000169	intersubunit interface [polypeptide binding]; other site
526218000170	Zn2+ binding site [ion binding]; other site
526218000171	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
526218000172	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
526218000173	NAD(P) binding site [chemical binding]; other site
526218000174	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
526218000175	homotrimer interaction site [polypeptide binding]; other site
526218000176	putative active site [active]
526218000177	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
526218000178	dimer interface [polypeptide binding]; other site
526218000179	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526218000180	ligand binding site [chemical binding]; other site
526218000181	Helix-turn-helix domain; Region: HTH_18; pfam12833
526218000182	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218000183	binding surface
526218000184	TPR motif; other site
526218000185	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
526218000186	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218000187	binding surface
526218000188	TPR motif; other site
526218000189	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218000190	Tetratricopeptide repeat; Region: TPR_12; pfam13424
526218000191	binding surface
526218000192	TPR motif; other site
526218000193	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218000194	TPR motif; other site
526218000195	binding surface
526218000196	Tetratricopeptide repeat; Region: TPR_16; pfam13432
526218000197	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218000198	binding surface
526218000199	TPR motif; other site
526218000200	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
526218000201	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
526218000202	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
526218000203	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
526218000204	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
526218000205	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
526218000206	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
526218000207	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
526218000208	catalytic residue [active]
526218000209	putative FPP diphosphate  binding site; other site
526218000210	putative FPP binding hydrophobic cleft; other site
526218000211	dimer interface [polypeptide binding]; other site
526218000212	putative IPP diphosphate binding site; other site
526218000213	Domain of unknown function (DUF1904); Region: DUF1904; pfam08921
526218000214	Predicted membrane protein [Function unknown]; Region: COG2855
526218000215	Transcriptional regulator [Transcription]; Region: LysR; COG0583
526218000216	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
526218000217	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
526218000218	dimerization interface [polypeptide binding]; other site
526218000219	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
526218000220	DNA binding residues [nucleotide binding]
526218000221	N-acetyltransferase B complex (NatB) non catalytic subunit; Region: NatB_MDM20; pfam09797
526218000222	flagellin; Provisional; Region: PRK14708
526218000223	Flavin Reductases; Region: FlaRed; cl00801
526218000224	ribosome recycling factor; Reviewed; Region: frr; PRK00083
526218000225	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
526218000226	hinge region; other site
526218000227	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
526218000228	putative nucleotide binding site [chemical binding]; other site
526218000229	uridine monophosphate binding site [chemical binding]; other site
526218000230	homohexameric interface [polypeptide binding]; other site
526218000231	elongation factor Ts; Provisional; Region: tsf; PRK09377
526218000232	UBA/TS-N domain; Region: UBA; pfam00627
526218000233	Elongation factor TS; Region: EF_TS; pfam00889
526218000234	Elongation factor TS; Region: EF_TS; pfam00889
526218000235	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
526218000236	rRNA interaction site [nucleotide binding]; other site
526218000237	S8 interaction site; other site
526218000238	putative laminin-1 binding site; other site
526218000239	Uncharacterized membrane protein [Function unknown]; Region: COG3949
526218000240	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
526218000241	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
526218000242	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
526218000243	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
526218000244	Histidine kinase; Region: HisKA_2; pfam07568
526218000245	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526218000246	ATP binding site [chemical binding]; other site
526218000247	Mg2+ binding site [ion binding]; other site
526218000248	G-X-G motif; other site
526218000249	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
526218000250	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526218000251	active site
526218000252	phosphorylation site [posttranslational modification]
526218000253	intermolecular recognition site; other site
526218000254	dimerization interface [polypeptide binding]; other site
526218000255	ANTAR domain; Region: ANTAR; pfam03861
526218000256	Helix-turn-helix domain; Region: HTH_18; pfam12833
526218000257	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
526218000258	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
526218000259	homotrimer interaction site [polypeptide binding]; other site
526218000260	putative active site [active]
526218000261	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
526218000262	homotrimer interaction site [polypeptide binding]; other site
526218000263	putative active site [active]
526218000264	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
526218000265	homotrimer interaction site [polypeptide binding]; other site
526218000266	putative active site [active]
526218000267	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
526218000268	Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; cl02331
526218000269	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
526218000270	DEAD-like helicases superfamily; Region: DEXDc; smart00487
526218000271	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526218000272	ATP binding site [chemical binding]; other site
526218000273	putative Mg++ binding site [ion binding]; other site
526218000274	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526218000275	nucleotide binding region [chemical binding]; other site
526218000276	ATP-binding site [chemical binding]; other site
526218000277	TRCF domain; Region: TRCF; pfam03461
526218000278	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
526218000279	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
526218000280	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
526218000281	RNA binding surface [nucleotide binding]; other site
526218000282	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14609
526218000283	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
526218000284	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
526218000285	SpoVG; Region: SpoVG; pfam04026
526218000286	maltose O-acetyltransferase; Provisional; Region: PRK10092
526218000287	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
526218000288	active site
526218000289	substrate binding site [chemical binding]; other site
526218000290	trimer interface [polypeptide binding]; other site
526218000291	CoA binding site [chemical binding]; other site
526218000292	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
526218000293	putative active site [active]
526218000294	catalytic residue [active]
526218000295	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
526218000296	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
526218000297	Walker A/P-loop; other site
526218000298	ATP binding site [chemical binding]; other site
526218000299	Q-loop/lid; other site
526218000300	ABC transporter signature motif; other site
526218000301	Walker B; other site
526218000302	D-loop; other site
526218000303	H-loop/switch region; other site
526218000304	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
526218000305	threonine dehydratase; Provisional; Region: PRK08198
526218000306	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
526218000307	tetramer interface [polypeptide binding]; other site
526218000308	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526218000309	catalytic residue [active]
526218000310	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
526218000311	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
526218000312	ACT domain; Region: ACT_5; pfam13710
526218000313	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
526218000314	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
526218000315	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
526218000316	PYR/PP interface [polypeptide binding]; other site
526218000317	dimer interface [polypeptide binding]; other site
526218000318	TPP binding site [chemical binding]; other site
526218000319	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
526218000320	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
526218000321	TPP-binding site [chemical binding]; other site
526218000322	dimer interface [polypeptide binding]; other site
526218000323	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
526218000324	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
526218000325	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
526218000326	2-isopropylmalate synthase; Validated; Region: PRK00915
526218000327	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
526218000328	active site
526218000329	catalytic residues [active]
526218000330	metal binding site [ion binding]; metal-binding site
526218000331	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
526218000332	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
526218000333	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
526218000334	active site
526218000335	catalytic residues [active]
526218000336	metal binding site [ion binding]; metal-binding site
526218000337	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
526218000338	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
526218000339	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
526218000340	putative active site [active]
526218000341	putative metal binding site [ion binding]; other site
526218000342	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
526218000343	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
526218000344	substrate binding site [chemical binding]; other site
526218000345	ligand binding site [chemical binding]; other site
526218000346	Src Homology 3 domain superfamily; Region: SH3; cl17036
526218000347	peptide ligand binding site [polypeptide binding]; other site
526218000348	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
526218000349	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
526218000350	substrate binding site [chemical binding]; other site
526218000351	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
526218000352	tartrate dehydrogenase; Region: TTC; TIGR02089
526218000353	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
526218000354	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
526218000355	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526218000356	homodimer interface [polypeptide binding]; other site
526218000357	catalytic residue [active]
526218000358	ketol-acid reductoisomerase; Provisional; Region: PRK05479
526218000359	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
526218000360	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
526218000361	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
526218000362	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
526218000363	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
526218000364	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
526218000365	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
526218000366	Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524
526218000367	active site residue [active]
526218000368	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436
526218000369	CPxP  motif; other site
526218000370	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
526218000371	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
526218000372	putative deacylase active site [active]
526218000373	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
526218000374	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
526218000375	Sulfatase; Region: Sulfatase; cl17466
526218000376	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
526218000377	active site
526218000378	P-loop; other site
526218000379	phosphorylation site [posttranslational modification]
526218000380	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
526218000381	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
526218000382	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
526218000383	intersubunit interface [polypeptide binding]; other site
526218000384	active site
526218000385	Zn2+ binding site [ion binding]; other site
526218000386	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
526218000387	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
526218000388	AP (apurinic/apyrimidinic) site pocket; other site
526218000389	DNA interaction; other site
526218000390	Metal-binding active site; metal-binding site
526218000391	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
526218000392	active site
526218000393	dimer interface [polypeptide binding]; other site
526218000394	magnesium binding site [ion binding]; other site
526218000395	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218000396	active site
526218000397	phosphorylation site [posttranslational modification]
526218000398	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218000399	active site
526218000400	phosphorylation site [posttranslational modification]
526218000401	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
526218000402	Sulfatase; Region: Sulfatase; cl17466
526218000403	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
526218000404	active site
526218000405	P-loop; other site
526218000406	phosphorylation site [posttranslational modification]
526218000407	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
526218000408	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
526218000409	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
526218000410	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
526218000411	PRD domain; Region: PRD; pfam00874
526218000412	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
526218000413	active site
526218000414	P-loop; other site
526218000415	phosphorylation site [posttranslational modification]
526218000416	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218000417	active site
526218000418	phosphorylation site [posttranslational modification]
526218000419	Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848
526218000420	catalytic triad [active]
526218000421	putative active site [active]
526218000422	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
526218000423	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218000424	Protein of unknown function (DUF1706); Region: DUF1706; pfam08020
526218000425	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526218000426	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
526218000427	active site
526218000428	motif I; other site
526218000429	motif II; other site
526218000430	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526218000431	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
526218000432	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
526218000433	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
526218000434	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
526218000435	active site
526218000436	P-loop; other site
526218000437	phosphorylation site [posttranslational modification]
526218000438	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218000439	active site
526218000440	phosphorylation site [posttranslational modification]
526218000441	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
526218000442	active site
526218000443	dimer interface [polypeptide binding]; other site
526218000444	magnesium binding site [ion binding]; other site
526218000445	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
526218000446	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
526218000447	AP (apurinic/apyrimidinic) site pocket; other site
526218000448	DNA interaction; other site
526218000449	Metal-binding active site; metal-binding site
526218000450	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
526218000451	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
526218000452	intersubunit interface [polypeptide binding]; other site
526218000453	active site
526218000454	Zn2+ binding site [ion binding]; other site
526218000455	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
526218000456	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526218000457	non-specific DNA binding site [nucleotide binding]; other site
526218000458	salt bridge; other site
526218000459	sequence-specific DNA binding site [nucleotide binding]; other site
526218000460	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
526218000461	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526218000462	active site
526218000463	motif I; other site
526218000464	motif II; other site
526218000465	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
526218000466	DAK2 domain; Region: Dak2; pfam02734
526218000467	EDD domain protein, DegV family; Region: DegV; TIGR00762
526218000468	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
526218000469	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218000470	active site
526218000471	phosphorylation site [posttranslational modification]
526218000472	FOG: CBS domain [General function prediction only]; Region: COG0517
526218000473	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
526218000474	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
526218000475	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
526218000476	transmembrane helices; other site
526218000477	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
526218000478	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
526218000479	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
526218000480	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526218000481	active site
526218000482	motif I; other site
526218000483	motif II; other site
526218000484	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
526218000485	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
526218000486	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
526218000487	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
526218000488	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
526218000489	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
526218000490	Mg++ binding site [ion binding]; other site
526218000491	putative catalytic motif [active]
526218000492	putative substrate binding site [chemical binding]; other site
526218000493	UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771
526218000494	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
526218000495	cell division protein FtsW; Region: ftsW; TIGR02614
526218000496	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
526218000497	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
526218000498	active site
526218000499	homodimer interface [polypeptide binding]; other site
526218000500	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
526218000501	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
526218000502	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
526218000503	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
526218000504	UDP-N-acetylmuramate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: MurB; COG0812
526218000505	FAD binding domain; Region: FAD_binding_4; pfam01565
526218000506	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
526218000507	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
526218000508	Cell division protein FtsQ; Region: FtsQ; pfam03799
526218000509	Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206
526218000510	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
526218000511	nucleotide binding site [chemical binding]; other site
526218000512	SulA interaction site; other site
526218000513	Ribosomal protein S6; Region: Ribosomal_S6; pfam01250
526218000514	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
526218000515	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
526218000516	dimer interface [polypeptide binding]; other site
526218000517	ssDNA binding site [nucleotide binding]; other site
526218000518	tetramer (dimer of dimers) interface [polypeptide binding]; other site
526218000519	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
526218000520	serine O-acetyltransferase; Region: cysE; TIGR01172
526218000521	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
526218000522	trimer interface [polypeptide binding]; other site
526218000523	active site
526218000524	substrate binding site [chemical binding]; other site
526218000525	CoA binding site [chemical binding]; other site
526218000526	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
526218000527	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
526218000528	dimer interface [polypeptide binding]; other site
526218000529	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526218000530	catalytic residue [active]
526218000531	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
526218000532	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
526218000533	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526218000534	Walker A motif; other site
526218000535	ATP binding site [chemical binding]; other site
526218000536	Walker B motif; other site
526218000537	arginine finger; other site
526218000538	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
526218000539	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
526218000540	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
526218000541	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
526218000542	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
526218000543	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
526218000544	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
526218000545	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
526218000546	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
526218000547	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
526218000548	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
526218000549	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
526218000550	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
526218000551	Divergent PAP2 family; Region: DUF212; pfam02681
526218000552	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
526218000553	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
526218000554	TPP-binding site; other site
526218000555	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
526218000556	PYR/PP interface [polypeptide binding]; other site
526218000557	dimer interface [polypeptide binding]; other site
526218000558	TPP binding site [chemical binding]; other site
526218000559	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
526218000560	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
526218000561	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
526218000562	RNA binding surface [nucleotide binding]; other site
526218000563	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526218000564	S-adenosylmethionine binding site [chemical binding]; other site
526218000565	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
526218000566	C-terminal peptidase (prc); Region: prc; TIGR00225
526218000567	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
526218000568	protein binding site [polypeptide binding]; other site
526218000569	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
526218000570	Catalytic dyad [active]
526218000571	Predicted methyltransferases [General function prediction only]; Region: COG0313
526218000572	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
526218000573	putative SAM binding site [chemical binding]; other site
526218000574	putative homodimer interface [polypeptide binding]; other site
526218000575	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
526218000576	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
526218000577	GTP/Mg2+ binding site [chemical binding]; other site
526218000578	G4 box; other site
526218000579	G5 box; other site
526218000580	G1 box; other site
526218000581	Switch I region; other site
526218000582	G2 box; other site
526218000583	G3 box; other site
526218000584	Switch II region; other site
526218000585	Domain of unknown function (DUF368); Region: DUF368; pfam04018
526218000586	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
526218000587	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
526218000588	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
526218000589	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
526218000590	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526218000591	motif II; other site
526218000592	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
526218000593	Domain of unknown function DUF20; Region: UPF0118; pfam01594
526218000594	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
526218000595	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
526218000596	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
526218000597	active site
526218000598	substrate binding site [chemical binding]; other site
526218000599	metal binding site [ion binding]; metal-binding site
526218000600	Methyltransferase domain; Region: Methyltransf_31; pfam13847
526218000601	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526218000602	S-adenosylmethionine binding site [chemical binding]; other site
526218000603	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
526218000604	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
526218000605	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
526218000606	F0F1 ATP synthase subunit C; Provisional; Region: PRK13469
526218000607	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
526218000608	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
526218000609	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
526218000610	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
526218000611	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
526218000612	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
526218000613	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
526218000614	beta subunit interaction interface [polypeptide binding]; other site
526218000615	Walker A motif; other site
526218000616	ATP binding site [chemical binding]; other site
526218000617	Walker B motif; other site
526218000618	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
526218000619	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
526218000620	core domain interface [polypeptide binding]; other site
526218000621	delta subunit interface [polypeptide binding]; other site
526218000622	epsilon subunit interface [polypeptide binding]; other site
526218000623	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
526218000624	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
526218000625	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
526218000626	alpha subunit interaction interface [polypeptide binding]; other site
526218000627	Walker A motif; other site
526218000628	ATP binding site [chemical binding]; other site
526218000629	Walker B motif; other site
526218000630	inhibitor binding site; inhibition site
526218000631	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
526218000632	F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355
526218000633	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
526218000634	gamma subunit interface [polypeptide binding]; other site
526218000635	epsilon subunit interface [polypeptide binding]; other site
526218000636	LBP interface [polypeptide binding]; other site
526218000637	META domain; Region: META; pfam03724
526218000638	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526218000639	H+ Antiporter protein; Region: 2A0121; TIGR00900
526218000640	putative substrate translocation pore; other site
526218000641	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
526218000642	putative catalytic site [active]
526218000643	putative metal binding site [ion binding]; other site
526218000644	putative phosphate binding site [ion binding]; other site
526218000645	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526218000646	Coenzyme A binding pocket [chemical binding]; other site
526218000647	Transcriptional regulator [Transcription]; Region: LytR; COG1316
526218000648	dephospho-CoA kinase; Region: TIGR00152
526218000649	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
526218000650	CoA-binding site [chemical binding]; other site
526218000651	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
526218000652	Mga helix-turn-helix domain; Region: Mga; pfam05043
526218000653	PRD domain; Region: PRD; pfam00874
526218000654	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
526218000655	active site
526218000656	P-loop; other site
526218000657	phosphorylation site [posttranslational modification]
526218000658	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218000659	active site
526218000660	phosphorylation site [posttranslational modification]
526218000661	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218000662	active site
526218000663	phosphorylation site [posttranslational modification]
526218000664	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
526218000665	active site
526218000666	P-loop; other site
526218000667	phosphorylation site [posttranslational modification]
526218000668	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
526218000669	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
526218000670	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
526218000671	active site
526218000672	galactonate dehydratase; Provisional; Region: PRK14017
526218000673	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
526218000674	putative active site pocket [active]
526218000675	putative metal binding site [ion binding]; other site
526218000676	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
526218000677	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
526218000678	active site
526218000679	intersubunit interface [polypeptide binding]; other site
526218000680	catalytic residue [active]
526218000681	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
526218000682	NADH(P)-binding; Region: NAD_binding_10; pfam13460
526218000683	NAD binding site [chemical binding]; other site
526218000684	substrate binding site [chemical binding]; other site
526218000685	putative active site [active]
526218000686	Predicted transcriptional regulators [Transcription]; Region: COG1733
526218000687	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
526218000688	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
526218000689	GTP-binding protein Der; Reviewed; Region: PRK00093
526218000690	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
526218000691	G1 box; other site
526218000692	GTP/Mg2+ binding site [chemical binding]; other site
526218000693	Switch I region; other site
526218000694	G2 box; other site
526218000695	Switch II region; other site
526218000696	G3 box; other site
526218000697	G4 box; other site
526218000698	G5 box; other site
526218000699	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
526218000700	G1 box; other site
526218000701	GTP/Mg2+ binding site [chemical binding]; other site
526218000702	Switch I region; other site
526218000703	G2 box; other site
526218000704	G3 box; other site
526218000705	Switch II region; other site
526218000706	G4 box; other site
526218000707	G5 box; other site
526218000708	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
526218000709	Domain of unknown function DUF20; Region: UPF0118; pfam01594
526218000710	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
526218000711	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526218000712	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526218000713	putative DNA binding site [nucleotide binding]; other site
526218000714	putative Zn2+ binding site [ion binding]; other site
526218000715	putative oxidoreductase; Provisional; Region: PRK10206
526218000716	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526218000717	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
526218000718	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218000719	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
526218000720	Phosphoglycerate kinase; Region: PGK; pfam00162
526218000721	substrate binding site [chemical binding]; other site
526218000722	hinge regions; other site
526218000723	ADP binding site [chemical binding]; other site
526218000724	catalytic site [active]
526218000725	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
526218000726	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
526218000727	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
526218000728	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
526218000729	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
526218000730	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
526218000731	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
526218000732	homotrimer interaction site [polypeptide binding]; other site
526218000733	zinc binding site [ion binding]; other site
526218000734	CDP-binding sites; other site
526218000735	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526218000736	Major Facilitator Superfamily; Region: MFS_1; pfam07690
526218000737	putative substrate translocation pore; other site
526218000738	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
526218000739	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
526218000740	nucleotide binding site [chemical binding]; other site
526218000741	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
526218000742	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
526218000743	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
526218000744	Walker A/P-loop; other site
526218000745	ATP binding site [chemical binding]; other site
526218000746	Q-loop/lid; other site
526218000747	ABC transporter signature motif; other site
526218000748	Walker B; other site
526218000749	D-loop; other site
526218000750	H-loop/switch region; other site
526218000751	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
526218000752	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
526218000753	putative ribose interaction site [chemical binding]; other site
526218000754	putative ADP binding site [chemical binding]; other site
526218000755	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
526218000756	active site
526218000757	catalytic triad [active]
526218000758	oxyanion hole [active]
526218000759	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
526218000760	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
526218000761	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
526218000762	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
526218000763	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
526218000764	F0F1 ATP synthase subunit C; Provisional; Region: PRK13469
526218000765	NAD synthetase; Provisional; Region: PRK13980
526218000766	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
526218000767	homodimer interface [polypeptide binding]; other site
526218000768	NAD binding pocket [chemical binding]; other site
526218000769	ATP binding pocket [chemical binding]; other site
526218000770	Mg binding site [ion binding]; other site
526218000771	active-site loop [active]
526218000772	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
526218000773	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
526218000774	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
526218000775	TrkA-N domain; Region: TrkA_N; pfam02254
526218000776	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
526218000777	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
526218000778	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
526218000779	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
526218000780	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
526218000781	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526218000782	S-adenosylmethionine binding site [chemical binding]; other site
526218000783	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
526218000784	ParB-like nuclease domain; Region: ParBc; pfam02195
526218000785	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
526218000786	Family of unknown function (DUF490); Region: DUF490; pfam04357
526218000787	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
526218000788	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
526218000789	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
526218000790	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
526218000791	Surface antigen; Region: Bac_surface_Ag; pfam01103
526218000792	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853
526218000793	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
526218000794	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
526218000795	trimer interface [polypeptide binding]; other site
526218000796	active site
526218000797	UDP-GlcNAc binding site [chemical binding]; other site
526218000798	lipid binding site [chemical binding]; lipid-binding site
526218000799	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
526218000800	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
526218000801	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
526218000802	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
526218000803	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
526218000804	dimerization interface [polypeptide binding]; other site
526218000805	domain crossover interface; other site
526218000806	redox-dependent activation switch; other site
526218000807	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
526218000808	anti sigma factor interaction site; other site
526218000809	regulatory phosphorylation site [posttranslational modification]; other site
526218000810	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
526218000811	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
526218000812	ATP-grasp domain; Region: ATP-grasp_4; cl17255
526218000813	S-ribosylhomocysteinase; Provisional; Region: PRK02260
526218000814	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
526218000815	active site
526218000816	Tic20-like protein; Region: Tic20; pfam09685
526218000817	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
526218000818	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
526218000819	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
526218000820	Walker A/P-loop; other site
526218000821	ATP binding site [chemical binding]; other site
526218000822	Q-loop/lid; other site
526218000823	ABC transporter signature motif; other site
526218000824	Walker B; other site
526218000825	D-loop; other site
526218000826	H-loop/switch region; other site
526218000827	FeS assembly protein SufB; Region: sufB; TIGR01980
526218000828	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
526218000829	FeS assembly protein SufD; Region: sufD; TIGR01981
526218000830	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
526218000831	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
526218000832	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
526218000833	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
526218000834	catalytic residue [active]
526218000835	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
526218000836	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
526218000837	trimerization site [polypeptide binding]; other site
526218000838	active site
526218000839	Domain of unknown function (DUF1877); Region: DUF1877; pfam08974
526218000840	glutamate dehydrogenase; Provisional; Region: PRK09414
526218000841	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
526218000842	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
526218000843	NAD(P) binding site [chemical binding]; other site
526218000844	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
526218000845	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
526218000846	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
526218000847	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
526218000848	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
526218000849	Walker A/P-loop; other site
526218000850	ATP binding site [chemical binding]; other site
526218000851	Q-loop/lid; other site
526218000852	ABC transporter signature motif; other site
526218000853	Walker B; other site
526218000854	D-loop; other site
526218000855	H-loop/switch region; other site
526218000856	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
526218000857	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
526218000858	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
526218000859	TM-ABC transporter signature motif; other site
526218000860	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
526218000861	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
526218000862	substrate binding site [chemical binding]; other site
526218000863	dimer interface [polypeptide binding]; other site
526218000864	ATP binding site [chemical binding]; other site
526218000865	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
526218000866	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
526218000867	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
526218000868	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
526218000869	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
526218000870	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
526218000871	haemagglutination activity domain; Region: Haemagg_act; pfam05860
526218000872	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
526218000873	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
526218000874	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
526218000875	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
526218000876	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
526218000877	dimer interface [polypeptide binding]; other site
526218000878	phosphorylation site [posttranslational modification]
526218000879	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526218000880	ATP binding site [chemical binding]; other site
526218000881	Mg2+ binding site [ion binding]; other site
526218000882	G-X-G motif; other site
526218000883	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
526218000884	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526218000885	active site
526218000886	phosphorylation site [posttranslational modification]
526218000887	intermolecular recognition site; other site
526218000888	dimerization interface [polypeptide binding]; other site
526218000889	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
526218000890	DNA binding site [nucleotide binding]
526218000891	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
526218000892	PhoU domain; Region: PhoU; pfam01895
526218000893	PhoU domain; Region: PhoU; pfam01895
526218000894	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
526218000895	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
526218000896	Walker A/P-loop; other site
526218000897	ATP binding site [chemical binding]; other site
526218000898	Q-loop/lid; other site
526218000899	ABC transporter signature motif; other site
526218000900	Walker B; other site
526218000901	D-loop; other site
526218000902	H-loop/switch region; other site
526218000903	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
526218000904	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
526218000905	active site
526218000906	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
526218000907	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
526218000908	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
526218000909	classical (c) SDRs; Region: SDR_c; cd05233
526218000910	NAD(P) binding site [chemical binding]; other site
526218000911	active site
526218000912	Domain of unknown function (DUF336); Region: DUF336; pfam03928
526218000913	GTPase RsgA; Reviewed; Region: PRK01889
526218000914	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
526218000915	RNA binding site [nucleotide binding]; other site
526218000916	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
526218000917	GTPase/Zn-binding domain interface [polypeptide binding]; other site
526218000918	GTP/Mg2+ binding site [chemical binding]; other site
526218000919	G4 box; other site
526218000920	G5 box; other site
526218000921	G1 box; other site
526218000922	Switch I region; other site
526218000923	G2 box; other site
526218000924	G3 box; other site
526218000925	Switch II region; other site
526218000926	Electron transfer DM13; Region: DM13; cl02735
526218000927	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
526218000928	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
526218000929	dimer interface [polypeptide binding]; other site
526218000930	active site
526218000931	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526218000932	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526218000933	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
526218000934	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
526218000935	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
526218000936	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
526218000937	Catalytic site [active]
526218000938	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
526218000939	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
526218000940	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526218000941	Coenzyme A binding pocket [chemical binding]; other site
526218000942	Uncharacterized conserved protein [Function unknown]; Region: COG1543
526218000943	N-terminal catalytic domain of  alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792
526218000944	active site
526218000945	substrate binding site [chemical binding]; other site
526218000946	catalytic site [active]
526218000947	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
526218000948	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
526218000949	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526218000950	active site
526218000951	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
526218000952	flavodoxin; Provisional; Region: PRK06242
526218000953	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
526218000954	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
526218000955	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526218000956	MarR family; Region: MarR_2; pfam12802
526218000957	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
526218000958	catalytic core [active]
526218000959	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
526218000960	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
526218000961	Autotransporter beta-domain; Region: Autotransporter; smart00869
526218000962	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
526218000963	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
526218000964	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
526218000965	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
526218000966	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
526218000967	active site
526218000968	metal binding site [ion binding]; metal-binding site
526218000969	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
526218000970	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
526218000971	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
526218000972	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
526218000973	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
526218000974	Transposase IS200 like; Region: Y1_Tnp; pfam01797
526218000975	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526218000976	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
526218000977	active site
526218000978	motif I; other site
526218000979	motif II; other site
526218000980	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526218000981	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
526218000982	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218000983	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526218000984	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526218000985	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218000986	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526218000987	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526218000988	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
526218000989	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218000990	binding surface
526218000991	TPR motif; other site
526218000992	TPR repeat; Region: TPR_11; pfam13414
526218000993	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218000994	binding surface
526218000995	TPR motif; other site
526218000996	TPR repeat; Region: TPR_11; pfam13414
526218000997	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
526218000998	Sel1 repeat; Region: Sel1; cl02723
526218000999	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218001000	binding surface
526218001001	TPR motif; other site
526218001002	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
526218001003	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218001004	binding surface
526218001005	TPR motif; other site
526218001006	Tetratricopeptide repeat; Region: TPR_12; pfam13424
526218001007	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
526218001008	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
526218001009	binding surface
526218001010	TPR motif; other site
526218001011	Tetratricopeptide repeat; Region: TPR_12; pfam13424
526218001012	TPR motif; other site
526218001013	Tetratricopeptide repeat; Region: TPR_1; pfam00515
526218001014	binding surface
526218001015	TPR repeat; Region: TPR_11; pfam13414
526218001016	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218001017	binding surface
526218001018	TPR motif; other site
526218001019	TPR repeat; Region: TPR_11; pfam13414
526218001020	Domain of unknown function (DUF4280); Region: DUF4280; pfam14107
526218001021	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
526218001022	NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530
526218001023	CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409
526218001024	active site
526218001025	metal binding site [ion binding]; metal-binding site
526218001026	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
526218001027	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
526218001028	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
526218001029	active site
526218001030	metal binding site [ion binding]; metal-binding site
526218001031	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
526218001032	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
526218001033	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
526218001034	active site
526218001035	metal binding site [ion binding]; metal-binding site
526218001036	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
526218001037	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526218001038	short chain dehydrogenase; Provisional; Region: PRK06197
526218001039	NAD(P) binding site [chemical binding]; other site
526218001040	active site
526218001041	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
526218001042	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
526218001043	substrate binding pocket [chemical binding]; other site
526218001044	catalytic triad [active]
526218001045	Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415
526218001046	putative mutase; Provisional; Region: PRK12383
526218001047	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811
526218001048	dimer interface [polypeptide binding]; other site
526218001049	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
526218001050	active site
526218001051	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
526218001052	substrate binding site [chemical binding]; other site
526218001053	catalytic residue [active]
526218001054	pyridoxal phosphate enzyme, MJ0158 family; Region: pyridox_MJ0158; TIGR03576
526218001055	Amidase; Region: Amidase; cl11426
526218001056	Protein of unknown function; Region: YhfT; pfam10797
526218001057	Protein of unknown function DUF2620; Region: DUF2620; pfam10941
526218001058	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
526218001059	active site
526218001060	substrate binding pocket [chemical binding]; other site
526218001061	homodimer interaction site [polypeptide binding]; other site
526218001062	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
526218001063	DNA-binding site [nucleotide binding]; DNA binding site
526218001064	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526218001065	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
526218001066	active site
526218001067	motif I; other site
526218001068	motif II; other site
526218001069	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
526218001070	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
526218001071	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
526218001072	Walker A/P-loop; other site
526218001073	ATP binding site [chemical binding]; other site
526218001074	Q-loop/lid; other site
526218001075	ABC transporter signature motif; other site
526218001076	Walker B; other site
526218001077	D-loop; other site
526218001078	H-loop/switch region; other site
526218001079	TOBE domain; Region: TOBE; pfam03459
526218001080	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
526218001081	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
526218001082	Zn2+ binding site [ion binding]; other site
526218001083	Mg2+ binding site [ion binding]; other site
526218001084	Peptidase family M48; Region: Peptidase_M48; cl12018
526218001085	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
526218001086	Phosphotransferase enzyme family; Region: APH; pfam01636
526218001087	active site
526218001088	ATP binding site [chemical binding]; other site
526218001089	antibiotic binding site [chemical binding]; other site
526218001090	Peptidase family M48; Region: Peptidase_M48; pfam01435
526218001091	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
526218001092	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526218001093	non-specific DNA binding site [nucleotide binding]; other site
526218001094	salt bridge; other site
526218001095	sequence-specific DNA binding site [nucleotide binding]; other site
526218001096	asparagine synthetase B; Provisional; Region: asnB; PRK09431
526218001097	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
526218001098	active site
526218001099	dimer interface [polypeptide binding]; other site
526218001100	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
526218001101	Ligand Binding Site [chemical binding]; other site
526218001102	Molecular Tunnel; other site
526218001103	SnoaL-like domain; Region: SnoaL_2; pfam12680
526218001104	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
526218001105	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526218001106	FeS/SAM binding site; other site
526218001107	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
526218001108	Methanothermobacter thermautotrophicus Mth212-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Mth212-like_AP-endo; cd09085
526218001109	active site
526218001110	putative catalytic site [active]
526218001111	phosphate binding site A [ion binding]; other site
526218001112	DNA binding site [nucleotide binding]
526218001113	metal binding site A [ion binding]; metal-binding site
526218001114	putative AP binding site [nucleotide binding]; other site
526218001115	putative metal binding site B [ion binding]; other site
526218001116	phosphate binding site B [ion binding]; other site
526218001117	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
526218001118	active site
526218001119	catalytic residues [active]
526218001120	DNA binding site [nucleotide binding]
526218001121	Int/Topo IB signature motif; other site
526218001122	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
526218001123	cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776
526218001124	Uncharacterized conserved protein [Function unknown]; Region: COG1912
526218001125	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
526218001126	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
526218001127	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
526218001128	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
526218001129	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
526218001130	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
526218001131	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
526218001132	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
526218001133	catalytic residue [active]
526218001134	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
526218001135	active site
526218001136	metal-binding site [ion binding]
526218001137	nucleotide-binding site [chemical binding]; other site
526218001138	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
526218001139	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530
526218001140	metal binding site [ion binding]; metal-binding site
526218001141	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526218001142	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
526218001143	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
526218001144	Transposase; Region: HTH_Tnp_1; cl17663
526218001145	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
526218001146	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526218001147	active site
526218001148	motif I; other site
526218001149	motif II; other site
526218001150	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526218001151	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526218001152	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
526218001153	active site
526218001154	motif I; other site
526218001155	motif II; other site
526218001156	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526218001157	motif II; other site
526218001158	short chain dehydrogenase; Provisional; Region: PRK08263
526218001159	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
526218001160	NADP binding site [chemical binding]; other site
526218001161	active site
526218001162	steroid binding site; other site
526218001163	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
526218001164	Transposase; Region: HTH_Tnp_1; pfam01527
526218001165	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
526218001166	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
526218001167	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
526218001168	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
526218001169	ligand binding site [chemical binding]; other site
526218001170	flexible hinge region; other site
526218001171	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
526218001172	PemK-like protein; Region: PemK; pfam02452
526218001173	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
526218001174	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
526218001175	Domain of unknown function (DUF4280); Region: DUF4280; pfam14107
526218001176	Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436
526218001177	Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436
526218001178	Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436
526218001179	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
526218001180	Domain of unknown function (DUF4280); Region: DUF4280; pfam14107
526218001181	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
526218001182	protein-splicing catalytic site; other site
526218001183	thioester formation/cholesterol transfer; other site
526218001184	Pretoxin HINT domain; Region: PT-HINT; pfam07591
526218001185	A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414
526218001186	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
526218001187	TPR repeat; Region: TPR_11; pfam13414
526218001188	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442
526218001189	protein-splicing catalytic site; other site
526218001190	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
526218001191	protein-splicing catalytic site; other site
526218001192	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
526218001193	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
526218001194	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
526218001195	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
526218001196	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
526218001197	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
526218001198	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
526218001199	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
526218001200	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
526218001201	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
526218001202	ligand binding site [chemical binding]; other site
526218001203	flexible hinge region; other site
526218001204	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
526218001205	Domain of unknown function (DUF4280); Region: DUF4280; pfam14107
526218001206	TPR repeat; Region: TPR_11; pfam13414
526218001207	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218001208	binding surface
526218001209	TPR motif; other site
526218001210	Tetratricopeptide repeat; Region: TPR_12; pfam13424
526218001211	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
526218001212	multidrug resistance protein MdtN; Provisional; Region: PRK10476
526218001213	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
526218001214	HlyD family secretion protein; Region: HlyD_3; pfam13437
526218001215	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
526218001216	active site 1 [active]
526218001217	dimer interface [polypeptide binding]; other site
526218001218	hexamer interface [polypeptide binding]; other site
526218001219	active site 2 [active]
526218001220	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
526218001221	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
526218001222	NAD binding site [chemical binding]; other site
526218001223	sugar binding site [chemical binding]; other site
526218001224	divalent metal binding site [ion binding]; other site
526218001225	tetramer (dimer of dimers) interface [polypeptide binding]; other site
526218001226	dimer interface [polypeptide binding]; other site
526218001227	transcriptional antiterminator BglG; Provisional; Region: PRK09772
526218001228	CAT RNA binding domain; Region: CAT_RBD; smart01061
526218001229	PRD domain; Region: PRD; pfam00874
526218001230	PRD domain; Region: PRD; pfam00874
526218001231	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
526218001232	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
526218001233	active site turn [active]
526218001234	phosphorylation site [posttranslational modification]
526218001235	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
526218001236	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
526218001237	HPr interaction site; other site
526218001238	glycerol kinase (GK) interaction site [polypeptide binding]; other site
526218001239	active site
526218001240	phosphorylation site [posttranslational modification]
526218001241	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526218001242	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526218001243	DNA binding residues [nucleotide binding]
526218001244	dimerization interface [polypeptide binding]; other site
526218001245	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218001246	TraX protein; Region: TraX; pfam05857
526218001247	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
526218001248	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
526218001249	substrate binding pocket [chemical binding]; other site
526218001250	membrane-bound complex binding site; other site
526218001251	hinge residues; other site
526218001252	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
526218001253	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
526218001254	Walker A/P-loop; other site
526218001255	ATP binding site [chemical binding]; other site
526218001256	Q-loop/lid; other site
526218001257	ABC transporter signature motif; other site
526218001258	Walker B; other site
526218001259	D-loop; other site
526218001260	H-loop/switch region; other site
526218001261	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
526218001262	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526218001263	dimer interface [polypeptide binding]; other site
526218001264	conserved gate region; other site
526218001265	putative PBP binding loops; other site
526218001266	ABC-ATPase subunit interface; other site
526218001267	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
526218001268	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
526218001269	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
526218001270	catalytic residues [active]
526218001271	sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912
526218001272	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
526218001273	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
526218001274	DJ-1 family protein; Region: not_thiJ; TIGR01383
526218001275	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
526218001276	conserved cys residue [active]
526218001277	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
526218001278	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
526218001279	DNA binding residues [nucleotide binding]
526218001280	putative dimer interface [polypeptide binding]; other site
526218001281	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
526218001282	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526218001283	NAD(P) binding site [chemical binding]; other site
526218001284	active site
526218001285	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
526218001286	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
526218001287	active site
526218001288	catalytic tetrad [active]
526218001289	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
526218001290	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526218001291	putative substrate translocation pore; other site
526218001292	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526218001293	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526218001294	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
526218001295	tRNA_anti-like; Region: tRNA_anti-like; pfam12869
526218001296	myosin-cross-reactive antigen; Provisional; Region: PRK13977
526218001297	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
526218001298	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
526218001299	PYR/PP interface [polypeptide binding]; other site
526218001300	dimer interface [polypeptide binding]; other site
526218001301	TPP binding site [chemical binding]; other site
526218001302	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
526218001303	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
526218001304	TPP-binding site [chemical binding]; other site
526218001305	dimer interface [polypeptide binding]; other site
526218001306	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
526218001307	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
526218001308	putative valine binding site [chemical binding]; other site
526218001309	dimer interface [polypeptide binding]; other site
526218001310	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
526218001311	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526218001312	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526218001313	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
526218001314	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
526218001315	intersubunit interface [polypeptide binding]; other site
526218001316	active site
526218001317	zinc binding site [ion binding]; other site
526218001318	Na+ binding site [ion binding]; other site
526218001319	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218001320	active site
526218001321	phosphorylation site [posttranslational modification]
526218001322	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
526218001323	active site
526218001324	P-loop; other site
526218001325	phosphorylation site [posttranslational modification]
526218001326	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
526218001327	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
526218001328	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218001329	DKNYY family; Region: DKNYY; pfam13644
526218001330	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
526218001331	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
526218001332	Domain of unknown function (DUF4260); Region: DUF4260; pfam14079
526218001333	Protein of unknown function, DUF606; Region: DUF606; pfam04657
526218001334	Protein of unknown function, DUF606; Region: DUF606; pfam04657
526218001335	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
526218001336	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
526218001337	ligand binding site [chemical binding]; other site
526218001338	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
526218001339	Helix-turn-helix domain; Region: HTH_31; pfam13560
526218001340	salt bridge; other site
526218001341	non-specific DNA binding site [nucleotide binding]; other site
526218001342	sequence-specific DNA binding site [nucleotide binding]; other site
526218001343	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
526218001344	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
526218001345	catalytic motif [active]
526218001346	Catalytic residue [active]
526218001347	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
526218001348	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
526218001349	dimer interface [polypeptide binding]; other site
526218001350	phosphorylation site [posttranslational modification]
526218001351	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526218001352	ATP binding site [chemical binding]; other site
526218001353	Mg2+ binding site [ion binding]; other site
526218001354	G-X-G motif; other site
526218001355	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
526218001356	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526218001357	active site
526218001358	phosphorylation site [posttranslational modification]
526218001359	intermolecular recognition site; other site
526218001360	dimerization interface [polypeptide binding]; other site
526218001361	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
526218001362	DNA binding site [nucleotide binding]
526218001363	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
526218001364	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
526218001365	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
526218001366	Walker A/P-loop; other site
526218001367	ATP binding site [chemical binding]; other site
526218001368	Q-loop/lid; other site
526218001369	ABC transporter signature motif; other site
526218001370	Walker B; other site
526218001371	D-loop; other site
526218001372	H-loop/switch region; other site
526218001373	NIL domain; Region: NIL; cl09633
526218001374	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526218001375	dimer interface [polypeptide binding]; other site
526218001376	conserved gate region; other site
526218001377	ABC-ATPase subunit interface; other site
526218001378	NLPA lipoprotein; Region: Lipoprotein_9; cl17547
526218001379	Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596
526218001380	putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112
526218001381	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
526218001382	DNA binding residues [nucleotide binding]
526218001383	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
526218001384	putative dimer interface [polypeptide binding]; other site
526218001385	Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805
526218001386	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
526218001387	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
526218001388	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
526218001389	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
526218001390	ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682
526218001391	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
526218001392	putative Cl- selectivity filter; other site
526218001393	putative pore gating glutamate residue; other site
526218001394	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
526218001395	FMN binding site [chemical binding]; other site
526218001396	dimer interface [polypeptide binding]; other site
526218001397	multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575
526218001398	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
526218001399	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
526218001400	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
526218001401	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
526218001402	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526218001403	active site
526218001404	motif I; other site
526218001405	motif II; other site
526218001406	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
526218001407	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
526218001408	SnoaL-like domain; Region: SnoaL_3; pfam13474
526218001409	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
526218001410	anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055
526218001411	anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221
526218001412	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
526218001413	FAD binding pocket [chemical binding]; other site
526218001414	FAD binding motif [chemical binding]; other site
526218001415	phosphate binding motif [ion binding]; other site
526218001416	beta-alpha-beta structure motif; other site
526218001417	NAD binding pocket [chemical binding]; other site
526218001418	Iron coordination center [ion binding]; other site
526218001419	sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912
526218001420	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
526218001421	4Fe-4S binding domain; Region: Fer4; pfam00037
526218001422	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218001423	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526218001424	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526218001425	Predicted transcriptional regulators [Transcription]; Region: COG1733
526218001426	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
526218001427	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
526218001428	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
526218001429	Nitrogen regulatory protein P-II; Region: P-II; smart00938
526218001430	Initiator Replication protein; Region: Rep_3; pfam01051
526218001431	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
526218001432	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
526218001433	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
526218001434	active site turn [active]
526218001435	phosphorylation site [posttranslational modification]
526218001436	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
526218001437	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526218001438	active site
526218001439	motif I; other site
526218001440	motif II; other site
526218001441	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
526218001442	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
526218001443	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
526218001444	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
526218001445	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
526218001446	active site
526218001447	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
526218001448	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
526218001449	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
526218001450	active site
526218001451	catalytic tetrad [active]
526218001452	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
526218001453	amino acid carrier protein; Region: agcS; TIGR00835
526218001454	Methyltransferase domain; Region: Methyltransf_31; pfam13847
526218001455	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526218001456	S-adenosylmethionine binding site [chemical binding]; other site
526218001457	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
526218001458	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
526218001459	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
526218001460	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
526218001461	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
526218001462	NAD binding site [chemical binding]; other site
526218001463	homodimer interface [polypeptide binding]; other site
526218001464	active site
526218001465	substrate binding site [chemical binding]; other site
526218001466	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
526218001467	active site
526218001468	catalytic residues [active]
526218001469	galactokinase; Provisional; Region: PRK05322
526218001470	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
526218001471	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
526218001472	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
526218001473	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
526218001474	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
526218001475	nucleotide binding site [chemical binding]; other site
526218001476	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
526218001477	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
526218001478	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
526218001479	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
526218001480	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
526218001481	N-terminal plug; other site
526218001482	ligand-binding site [chemical binding]; other site
526218001483	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
526218001484	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
526218001485	ABC-ATPase subunit  interface; other site
526218001486	dimer interface [polypeptide binding]; other site
526218001487	putative PBP binding regions; other site
526218001488	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
526218001489	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
526218001490	Walker A/P-loop; other site
526218001491	ATP binding site [chemical binding]; other site
526218001492	Q-loop/lid; other site
526218001493	ABC transporter signature motif; other site
526218001494	Walker B; other site
526218001495	D-loop; other site
526218001496	H-loop/switch region; other site
526218001497	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
526218001498	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
526218001499	intersubunit interface [polypeptide binding]; other site
526218001500	heme oxygenase, HugZ family; Region: heme_ox_HugZ; TIGR04109
526218001501	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
526218001502	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
526218001503	putative heme utilization radical SAM enzyme HutW; Region: rSAM_HutW; TIGR04107
526218001504	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526218001505	FeS/SAM binding site; other site
526218001506	Flavodoxin domain; Region: Flavodoxin_3; pfam12641
526218001507	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
526218001508	guanine deaminase; Region: guan_deamin; TIGR02967
526218001509	active site
526218001510	NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272
526218001511	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
526218001512	nucleotide binding pocket [chemical binding]; other site
526218001513	K-X-D-G motif; other site
526218001514	catalytic site [active]
526218001515	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
526218001516	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
526218001517	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
526218001518	Dimer interface [polypeptide binding]; other site
526218001519	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
526218001520	putative active site [active]
526218001521	dimerization interface [polypeptide binding]; other site
526218001522	putative tRNAtyr binding site [nucleotide binding]; other site
526218001523	NlpC/P60 family; Region: NLPC_P60; pfam00877
526218001524	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
526218001525	nudix motif; other site
526218001526	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
526218001527	putative FMN binding site [chemical binding]; other site
526218001528	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
526218001529	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
526218001530	active site
526218001531	catalytic tetrad [active]
526218001532	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
526218001533	catalytic core [active]
526218001534	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
526218001535	hypothetical protein; Validated; Region: PRK02101
526218001536	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
526218001537	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
526218001538	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
526218001539	OstA-like protein; Region: OstA; cl00844
526218001540	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
526218001541	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
526218001542	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
526218001543	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
526218001544	active site
526218001545	dimer interface [polypeptide binding]; other site
526218001546	motif 1; other site
526218001547	motif 2; other site
526218001548	motif 3; other site
526218001549	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
526218001550	anticodon binding site; other site
526218001551	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
526218001552	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
526218001553	putative active site [active]
526218001554	PhoH-like protein; Region: PhoH; pfam02562
526218001555	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
526218001556	active site
526218001557	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
526218001558	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
526218001559	active site
526218001560	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
526218001561	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
526218001562	active site
526218001563	nucleotide binding site [chemical binding]; other site
526218001564	HIGH motif; other site
526218001565	KMSKS motif; other site
526218001566	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
526218001567	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
526218001568	Glycoprotease family; Region: Peptidase_M22; pfam00814
526218001569	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
526218001570	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
526218001571	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
526218001572	GTP binding site [chemical binding]; other site
526218001573	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
526218001574	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
526218001575	propionate/acetate kinase; Provisional; Region: PRK12379
526218001576	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
526218001577	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
526218001578	putative dimer interface [polypeptide binding]; other site
526218001579	[2Fe-2S] cluster binding site [ion binding]; other site
526218001580	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
526218001581	dimer interface [polypeptide binding]; other site
526218001582	[2Fe-2S] cluster binding site [ion binding]; other site
526218001583	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
526218001584	SLBB domain; Region: SLBB; pfam10531
526218001585	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
526218001586	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
526218001587	4Fe-4S binding domain; Region: Fer4; pfam00037
526218001588	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
526218001589	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
526218001590	catalytic loop [active]
526218001591	iron binding site [ion binding]; other site
526218001592	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
526218001593	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
526218001594	4Fe-4S binding domain; Region: Fer4; pfam00037
526218001595	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
526218001596	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
526218001597	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
526218001598	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
526218001599	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
526218001600	ligand binding site [chemical binding]; other site
526218001601	Adhesion protein FadA; Region: FadA; pfam09403
526218001602	Adhesion protein FadA; Region: FadA; pfam09403
526218001603	Domain of unknown function (DUF4407); Region: DUF4407; pfam14362
526218001604	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
526218001605	dimer interface [polypeptide binding]; other site
526218001606	[2Fe-2S] cluster binding site [ion binding]; other site
526218001607	TPR repeat; Region: TPR_11; pfam13414
526218001608	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218001609	binding surface
526218001610	TPR motif; other site
526218001611	TPR repeat; Region: TPR_11; pfam13414
526218001612	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
526218001613	binding surface
526218001614	TPR motif; other site
526218001615	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
526218001616	Ligand Binding Site [chemical binding]; other site
526218001617	TIGR00269 family protein; Region: TIGR00269
526218001618	FeoA domain; Region: FeoA; cl00838
526218001619	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
526218001620	ferrous iron transporter FeoB; Region: feoB; TIGR00437
526218001621	G1 box; other site
526218001622	GTP/Mg2+ binding site [chemical binding]; other site
526218001623	Switch I region; other site
526218001624	G2 box; other site
526218001625	G3 box; other site
526218001626	Switch II region; other site
526218001627	G4 box; other site
526218001628	G5 box; other site
526218001629	Nucleoside recognition; Region: Gate; pfam07670
526218001630	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
526218001631	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
526218001632	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
526218001633	Substrate binding site; other site
526218001634	Mg++ binding site; other site
526218001635	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
526218001636	active site
526218001637	substrate binding site [chemical binding]; other site
526218001638	CoA binding site [chemical binding]; other site
526218001639	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
526218001640	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
526218001641	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
526218001642	active site
526218001643	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
526218001644	Type II/IV secretion system protein; Region: T2SE; pfam00437
526218001645	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
526218001646	Walker A motif; other site
526218001647	ATP binding site [chemical binding]; other site
526218001648	Walker B motif; other site
526218001649	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
526218001650	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
526218001651	AzlC protein; Region: AzlC; pfam03591
526218001652	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
526218001653	DAK2 domain; Region: Dak2; pfam02734
526218001654	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
526218001655	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
526218001656	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
526218001657	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
526218001658	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
526218001659	Metal-binding active site; metal-binding site
526218001660	Cupin domain; Region: Cupin_2; pfam07883
526218001661	Cupin domain; Region: Cupin_2; cl17218
526218001662	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
526218001663	HTH domain; Region: HTH_11; cl17392
526218001664	Mga helix-turn-helix domain; Region: Mga; pfam05043
526218001665	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
526218001666	active site
526218001667	P-loop; other site
526218001668	phosphorylation site [posttranslational modification]
526218001669	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218001670	active site
526218001671	phosphorylation site [posttranslational modification]
526218001672	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
526218001673	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
526218001674	NAD(P) binding site [chemical binding]; other site
526218001675	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
526218001676	intersubunit interface [polypeptide binding]; other site
526218001677	active site
526218001678	zinc binding site [ion binding]; other site
526218001679	Na+ binding site [ion binding]; other site
526218001680	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218001681	active site
526218001682	phosphorylation site [posttranslational modification]
526218001683	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
526218001684	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
526218001685	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
526218001686	active site
526218001687	P-loop; other site
526218001688	phosphorylation site [posttranslational modification]
526218001689	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
526218001690	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
526218001691	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
526218001692	Protein of unknown function (DUF1349); Region: DUF1349; pfam07081
526218001693	hypothetical protein; Provisional; Region: PRK11770
526218001694	Domain of unknown function (DUF307); Region: DUF307; pfam03733
526218001695	Domain of unknown function (DUF307); Region: DUF307; pfam03733
526218001696	SWIM zinc finger; Region: SWIM; pfam04434
526218001697	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
526218001698	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
526218001699	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526218001700	ATP binding site [chemical binding]; other site
526218001701	putative Mg++ binding site [ion binding]; other site
526218001702	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526218001703	nucleotide binding region [chemical binding]; other site
526218001704	ATP-binding site [chemical binding]; other site
526218001705	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u5; cd11542
526218001706	metal binding site [ion binding]; metal-binding site
526218001707	metal-dependent hydrolase; Provisional; Region: PRK00685
526218001708	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
526218001709	Transcriptional regulator [Transcription]; Region: IclR; COG1414
526218001710	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
526218001711	Bacterial transcriptional regulator; Region: IclR; pfam01614
526218001712	2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935
526218001713	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
526218001714	NADP binding site [chemical binding]; other site
526218001715	homodimer interface [polypeptide binding]; other site
526218001716	active site
526218001717	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
526218001718	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
526218001719	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
526218001720	Uncharacterized conserved protein [Function unknown]; Region: COG3589
526218001721	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
526218001722	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
526218001723	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
526218001724	substrate binding site [chemical binding]; other site
526218001725	ATP binding site [chemical binding]; other site
526218001726	dihydroorotase; Provisional; Region: PRK09237
526218001727	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
526218001728	active site
526218001729	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
526218001730	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
526218001731	catalytic residue [active]
526218001732	Protein of unknown function (DUF1341); Region: DUF1341; cl06211
526218001733	prolyl-tRNA synthetase; Provisional; Region: PRK09194
526218001734	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
526218001735	dimer interface [polypeptide binding]; other site
526218001736	motif 1; other site
526218001737	active site
526218001738	motif 2; other site
526218001739	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
526218001740	putative deacylase active site [active]
526218001741	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
526218001742	active site
526218001743	motif 3; other site
526218001744	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
526218001745	anticodon binding site; other site
526218001746	Methyltransferase domain; Region: Methyltransf_31; pfam13847
526218001747	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526218001748	S-adenosylmethionine binding site [chemical binding]; other site
526218001749	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
526218001750	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
526218001751	FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944
526218001752	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526218001753	putative Zn2+ binding site [ion binding]; other site
526218001754	putative DNA binding site [nucleotide binding]; other site
526218001755	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
526218001756	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
526218001757	dimer interface [polypeptide binding]; other site
526218001758	catalytic triad [active]
526218001759	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
526218001760	dimer interface [polypeptide binding]; other site
526218001761	FMN binding site [chemical binding]; other site
526218001762	NADPH bind site [chemical binding]; other site
526218001763	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
526218001764	galactarate dehydratase; Region: galactar-dH20; TIGR03248
526218001765	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
526218001766	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
526218001767	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
526218001768	Walker A/P-loop; other site
526218001769	ATP binding site [chemical binding]; other site
526218001770	Q-loop/lid; other site
526218001771	ABC transporter signature motif; other site
526218001772	Walker B; other site
526218001773	D-loop; other site
526218001774	H-loop/switch region; other site
526218001775	TOBE domain; Region: TOBE; pfam03459
526218001776	Glucuronate isomerase; Region: UxaC; pfam02614
526218001777	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
526218001778	Transcriptional regulators [Transcription]; Region: GntR; COG1802
526218001779	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526218001780	DNA-binding site [nucleotide binding]; DNA binding site
526218001781	FCD domain; Region: FCD; pfam07729
526218001782	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
526218001783	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
526218001784	NAD(P) binding site [chemical binding]; other site
526218001785	LDH/MDH dimer interface [polypeptide binding]; other site
526218001786	substrate binding site [chemical binding]; other site
526218001787	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
526218001788	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
526218001789	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
526218001790	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
526218001791	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526218001792	dimer interface [polypeptide binding]; other site
526218001793	conserved gate region; other site
526218001794	putative PBP binding loops; other site
526218001795	ABC-ATPase subunit interface; other site
526218001796	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
526218001797	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526218001798	dimer interface [polypeptide binding]; other site
526218001799	conserved gate region; other site
526218001800	putative PBP binding loops; other site
526218001801	ABC-ATPase subunit interface; other site
526218001802	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
526218001803	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
526218001804	altronate oxidoreductase; Provisional; Region: PRK03643
526218001805	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
526218001806	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
526218001807	Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381
526218001808	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
526218001809	magnesium-transporting ATPase; Provisional; Region: PRK15122
526218001810	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
526218001811	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
526218001812	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
526218001813	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
526218001814	Soluble P-type ATPase [General function prediction only]; Region: COG4087
526218001815	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
526218001816	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
526218001817	Coenzyme A binding pocket [chemical binding]; other site
526218001818	Uncharacterized conserved protein [Function unknown]; Region: COG3603
526218001819	Family description; Region: ACT_7; pfam13840
526218001820	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
526218001821	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
526218001822	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
526218001823	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
526218001824	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
526218001825	catalytic residue [active]
526218001826	DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339
526218001827	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
526218001828	DNA binding site [nucleotide binding]
526218001829	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
526218001830	putative ligand binding site [chemical binding]; other site
526218001831	putative dimerization interface [polypeptide binding]; other site
526218001832	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
526218001833	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
526218001834	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
526218001835	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
526218001836	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
526218001837	Trehalase; Region: Trehalase; cl17346
526218001838	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
526218001839	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526218001840	dimer interface [polypeptide binding]; other site
526218001841	conserved gate region; other site
526218001842	putative PBP binding loops; other site
526218001843	ABC-ATPase subunit interface; other site
526218001844	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526218001845	dimer interface [polypeptide binding]; other site
526218001846	conserved gate region; other site
526218001847	ABC-ATPase subunit interface; other site
526218001848	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
526218001849	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
526218001850	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
526218001851	EamA-like transporter family; Region: EamA; pfam00892
526218001852	Autotransporter beta-domain; Region: Autotransporter; smart00869
526218001853	Adhesion protein FadA; Region: FadA; pfam09403
526218001854	Protein of unknown function (DUF3373); Region: DUF3373; pfam11853
526218001855	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
526218001856	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
526218001857	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
526218001858	ligand binding site [chemical binding]; other site
526218001859	Right handed beta helix region; Region: Beta_helix; pfam13229
526218001860	Right handed beta helix region; Region: Beta_helix; pfam13229
526218001861	Autotransporter beta-domain; Region: Autotransporter; smart00869
526218001862	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
526218001863	Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382
526218001864	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526218001865	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526218001866	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
526218001867	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
526218001868	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
526218001869	Ligand Binding Site [chemical binding]; other site
526218001870	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
526218001871	RmuC family; Region: RmuC; pfam02646
526218001872	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
526218001873	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
526218001874	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
526218001875	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
526218001876	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
526218001877	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
526218001878	HIGH motif; other site
526218001879	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
526218001880	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
526218001881	active site
526218001882	KMSKS motif; other site
526218001883	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
526218001884	tRNA binding surface [nucleotide binding]; other site
526218001885	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
526218001886	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
526218001887	Ligand Binding Site [chemical binding]; other site
526218001888	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
526218001889	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
526218001890	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
526218001891	homodimer interface [polypeptide binding]; other site
526218001892	substrate-cofactor binding pocket; other site
526218001893	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526218001894	catalytic residue [active]
526218001895	Uncharacterized conserved protein [Function unknown]; Region: COG5361
526218001896	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
526218001897	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
526218001898	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
526218001899	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
526218001900	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
526218001901	active site
526218001902	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
526218001903	dimer interface [polypeptide binding]; other site
526218001904	ADP-ribose binding site [chemical binding]; other site
526218001905	active site
526218001906	nudix motif; other site
526218001907	metal binding site [ion binding]; metal-binding site
526218001908	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218001909	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
526218001910	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
526218001911	ligand binding site [chemical binding]; other site
526218001912	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
526218001913	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
526218001914	Walker A/P-loop; other site
526218001915	ATP binding site [chemical binding]; other site
526218001916	Q-loop/lid; other site
526218001917	ABC transporter signature motif; other site
526218001918	Walker B; other site
526218001919	D-loop; other site
526218001920	H-loop/switch region; other site
526218001921	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
526218001922	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
526218001923	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
526218001924	TM-ABC transporter signature motif; other site
526218001925	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
526218001926	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
526218001927	TM-ABC transporter signature motif; other site
526218001928	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
526218001929	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526218001930	DNA-binding site [nucleotide binding]; DNA binding site
526218001931	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
526218001932	active site
526218001933	tetramer interface [polypeptide binding]; other site
526218001934	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
526218001935	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
526218001936	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218001937	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
526218001938	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
526218001939	FMN binding site [chemical binding]; other site
526218001940	substrate binding site [chemical binding]; other site
526218001941	putative catalytic residue [active]
526218001942	Predicted transcriptional regulators [Transcription]; Region: COG1733
526218001943	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
526218001944	hypothetical protein; Reviewed; Region: PRK09588
526218001945	Uncharacterized protein family UPF0027; Region: UPF0027; cl17455
526218001946	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
526218001947	RF-1 domain; Region: RF-1; cl17422
526218001948	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
526218001949	metal ion-dependent adhesion site (MIDAS); other site
526218001950	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
526218001951	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
526218001952	DNA-binding site [nucleotide binding]; DNA binding site
526218001953	GrpE; Region: GrpE; pfam01025
526218001954	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
526218001955	dimer interface [polypeptide binding]; other site
526218001956	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
526218001957	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
526218001958	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
526218001959	nucleotide binding site [chemical binding]; other site
526218001960	NEF interaction site [polypeptide binding]; other site
526218001961	SBD interface [polypeptide binding]; other site
526218001962	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
526218001963	active site
526218001964	catalytic residues [active]
526218001965	chaperone protein DnaJ; Provisional; Region: PRK10767
526218001966	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
526218001967	HSP70 interaction site [polypeptide binding]; other site
526218001968	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
526218001969	substrate binding site [polypeptide binding]; other site
526218001970	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
526218001971	Zn binding sites [ion binding]; other site
526218001972	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
526218001973	dimer interface [polypeptide binding]; other site
526218001974	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
526218001975	Preprotein translocase subunit; Region: YajC; pfam02699
526218001976	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
526218001977	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
526218001978	active site
526218001979	metal binding site [ion binding]; metal-binding site
526218001980	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
526218001981	Zn2+ binding site [ion binding]; other site
526218001982	Mg2+ binding site [ion binding]; other site
526218001983	ribonuclease R; Region: RNase_R; TIGR02063
526218001984	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
526218001985	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
526218001986	RNB domain; Region: RNB; pfam00773
526218001987	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
526218001988	RNA binding site [nucleotide binding]; other site
526218001989	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
526218001990	SmpB-tmRNA interface; other site
526218001991	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
526218001992	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
526218001993	active site
526218001994	catalytic tetrad [active]
526218001995	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526218001996	MarR family; Region: MarR; pfam01047
526218001997	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
526218001998	hydrophobic ligand binding site; other site
526218001999	Predicted transcriptional regulators [Transcription]; Region: COG1695
526218002000	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
526218002001	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
526218002002	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
526218002003	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
526218002004	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
526218002005	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
526218002006	Protein of unknown function (DUF1271); Region: DUF1271; pfam06902
526218002007	Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369
526218002008	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
526218002009	Transcriptional regulators [Transcription]; Region: GntR; COG1802
526218002010	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526218002011	DNA-binding site [nucleotide binding]; DNA binding site
526218002012	FCD domain; Region: FCD; pfam07729
526218002013	membrane protein FdrA; Validated; Region: PRK06091
526218002014	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526218002015	CoA binding domain; Region: CoA_binding; pfam02629
526218002016	CoA-ligase; Region: Ligase_CoA; pfam00549
526218002017	Protein of unknown function (DUF1116); Region: DUF1116; pfam06545
526218002018	Protein of unknown function (DUF2877); Region: DUF2877; pfam11392
526218002019	carbamate kinase; Reviewed; Region: PRK12686
526218002020	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
526218002021	putative substrate binding site [chemical binding]; other site
526218002022	nucleotide binding site [chemical binding]; other site
526218002023	nucleotide binding site [chemical binding]; other site
526218002024	homodimer interface [polypeptide binding]; other site
526218002025	putative inner membrane protein translocase component YidC; Validated; Region: PRK00247
526218002026	cytosine deaminase; Provisional; Region: PRK05985
526218002027	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
526218002028	active site
526218002029	Transcriptional regulators [Transcription]; Region: GntR; COG1802
526218002030	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526218002031	DNA-binding site [nucleotide binding]; DNA binding site
526218002032	putative bifunctional 2-polyprenylphenol hydroxylase/glutamate synthase subunit beta; Provisional; Region: PRK12778
526218002033	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
526218002034	FAD binding pocket [chemical binding]; other site
526218002035	FAD binding motif [chemical binding]; other site
526218002036	phosphate binding motif [ion binding]; other site
526218002037	beta-alpha-beta structure motif; other site
526218002038	NAD binding pocket [chemical binding]; other site
526218002039	Iron coordination center [ion binding]; other site
526218002040	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
526218002041	DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534
526218002042	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526218002043	DNA-binding site [nucleotide binding]; DNA binding site
526218002044	FCD domain; Region: FCD; pfam07729
526218002045	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
526218002046	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
526218002047	catalytic residues [active]
526218002048	catalytic nucleophile [active]
526218002049	Recombinase; Region: Recombinase; pfam07508
526218002050	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
526218002051	YopX protein; Region: YopX; pfam09643
526218002052	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
526218002053	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
526218002054	dimer interface [polypeptide binding]; other site
526218002055	ssDNA binding site [nucleotide binding]; other site
526218002056	tetramer (dimer of dimers) interface [polypeptide binding]; other site
526218002057	ERF superfamily; Region: ERF; pfam04404
526218002058	P22_AR N-terminal domain; Region: P22_AR_N; pfam10547
526218002059	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
526218002060	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526218002061	non-specific DNA binding site [nucleotide binding]; other site
526218002062	salt bridge; other site
526218002063	sequence-specific DNA binding site [nucleotide binding]; other site
526218002064	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
526218002065	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
526218002066	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526218002067	S-adenosylmethionine binding site [chemical binding]; other site
526218002068	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526218002069	non-specific DNA binding site [nucleotide binding]; other site
526218002070	salt bridge; other site
526218002071	sequence-specific DNA binding site [nucleotide binding]; other site
526218002072	Domain of unknown function (DUF955); Region: DUF955; pfam06114
526218002073	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
526218002074	non-specific DNA binding site [nucleotide binding]; other site
526218002075	salt bridge; other site
526218002076	sequence-specific DNA binding site [nucleotide binding]; other site
526218002077	Hypothetical protein (DUF2513); Region: DUF2513; pfam10711
526218002078	Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; cl09752
526218002079	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526218002080	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
526218002081	Walker A motif; other site
526218002082	ATP binding site [chemical binding]; other site
526218002083	Walker B motif; other site
526218002084	arginine finger; other site
526218002085	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
526218002086	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
526218002087	cofactor binding site; other site
526218002088	DNA binding site [nucleotide binding]
526218002089	substrate interaction site [chemical binding]; other site
526218002090	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
526218002091	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
526218002092	DNA methylase; Region: N6_N4_Mtase; pfam01555
526218002093	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526218002094	S-adenosylmethionine binding site [chemical binding]; other site
526218002095	ORF6N domain; Region: ORF6N; pfam10543
526218002096	YopX protein; Region: YopX; cl09859
526218002097	Protein of unknown function (DUF968); Region: DUF968; pfam06147
526218002098	Predicted DNA-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG1571
526218002099	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
526218002100	Catalytic site; other site
526218002101	P22_AR N-terminal domain; Region: P22_AR_N; pfam10547
526218002102	AntA/AntB antirepressor; Region: AntA; pfam08346
526218002103	Terminase small subunit; Region: Terminase_2; cl01513
526218002104	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
526218002105	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
526218002106	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
526218002107	Protein of unknown function (DUF3383); Region: DUF3383; pfam11863
526218002108	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
526218002109	Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; cl15410
526218002110	Protein of unknown function (DUF2612); Region: DUF2612; pfam11041
526218002111	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
526218002112	active site
526218002113	metal binding site [ion binding]; metal-binding site
526218002114	Excalibur calcium-binding domain; Region: Excalibur; smart00894
526218002115	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218002116	TPR motif; other site
526218002117	binding surface
526218002118	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
526218002119	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218002120	TPR motif; other site
526218002121	binding surface
526218002122	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
526218002123	binding surface
526218002124	TPR motif; other site
526218002125	Tetratricopeptide repeat; Region: TPR_12; pfam13424
526218002126	Protein of unknown function (DUF968); Region: DUF968; pfam06147
526218002127	DKNYY family; Region: DKNYY; pfam13644
526218002128	DKNYY family; Region: DKNYY; pfam13644
526218002129	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
526218002130	putative active site [active]
526218002131	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218002132	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
526218002133	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
526218002134	active site
526218002135	motif I; other site
526218002136	motif II; other site
526218002137	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526218002138	Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695
526218002139	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
526218002140	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
526218002141	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
526218002142	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
526218002143	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526218002144	motif II; other site
526218002145	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
526218002146	Protein of unknown function (DUF1538); Region: DUF1538; pfam07556
526218002147	Protein of unknown function (DUF1538); Region: DUF1538; pfam07556
526218002148	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
526218002149	conserved cys residue [active]
526218002150	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
526218002151	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526218002152	Walker A/P-loop; other site
526218002153	ATP binding site [chemical binding]; other site
526218002154	Q-loop/lid; other site
526218002155	ABC transporter signature motif; other site
526218002156	Walker B; other site
526218002157	D-loop; other site
526218002158	H-loop/switch region; other site
526218002159	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
526218002160	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
526218002161	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
526218002162	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
526218002163	stage V sporulation protein AD; Provisional; Region: PRK12404
526218002164	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
526218002165	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
526218002166	Phage tail tube protein FII; Region: Phage_tube; cl01390
526218002167	Phage Tail Protein X; Region: Phage_tail_X; cl02088
526218002168	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
526218002169	Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812
526218002170	Baseplate J-like protein; Region: Baseplate_J; cl01294
526218002171	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817
526218002172	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
526218002173	Methyltransferase domain; Region: Methyltransf_23; pfam13489
526218002174	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526218002175	S-adenosylmethionine binding site [chemical binding]; other site
526218002176	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
526218002177	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526218002178	Coenzyme A binding pocket [chemical binding]; other site
526218002179	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
526218002180	catalytic core [active]
526218002181	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
526218002182	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
526218002183	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526218002184	DNA-binding site [nucleotide binding]; DNA binding site
526218002185	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
526218002186	xanthine permease; Region: pbuX; TIGR03173
526218002187	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
526218002188	nucleoside/Zn binding site; other site
526218002189	dimer interface [polypeptide binding]; other site
526218002190	catalytic motif [active]
526218002191	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_12; cd12177
526218002192	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
526218002193	putative ligand binding site [chemical binding]; other site
526218002194	putative NAD binding site [chemical binding]; other site
526218002195	catalytic site [active]
526218002196	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
526218002197	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
526218002198	active site
526218002199	intersubunit interface [polypeptide binding]; other site
526218002200	catalytic residue [active]
526218002201	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
526218002202	active pocket/dimerization site; other site
526218002203	active site
526218002204	phosphorylation site [posttranslational modification]
526218002205	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
526218002206	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
526218002207	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
526218002208	active site
526218002209	phosphorylation site [posttranslational modification]
526218002210	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
526218002211	Initiator Replication protein; Region: Rep_3; pfam01051
526218002212	Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272
526218002213	Domain of unknown function (DUF4312); Region: DUF4312; pfam14189
526218002214	Domain of unknown function (DUF4311); Region: DUF4311; pfam14188
526218002215	Domain of unknown function (DUF4310); Region: DUF4310; pfam14187
526218002216	Protein of unknown function (DUF1341); Region: DUF1341; cl06211
526218002217	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218002218	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
526218002219	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
526218002220	nucleotide binding site [chemical binding]; other site
526218002221	Transcriptional regulators [Transcription]; Region: PurR; COG1609
526218002222	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
526218002223	DNA binding site [nucleotide binding]
526218002224	domain linker motif; other site
526218002225	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
526218002226	putative ligand binding site [chemical binding]; other site
526218002227	putative dimerization interface [polypeptide binding]; other site
526218002228	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218002229	Autotransporter beta-domain; Region: Autotransporter; smart00869
526218002230	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
526218002231	beta-galactosidase; Region: BGL; TIGR03356
526218002232	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
526218002233	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
526218002234	active site
526218002235	trimer interface [polypeptide binding]; other site
526218002236	allosteric site; other site
526218002237	active site lid [active]
526218002238	hexamer (dimer of trimers) interface [polypeptide binding]; other site
526218002239	replicative DNA helicase; Provisional; Region: PRK05973
526218002240	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
526218002241	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
526218002242	ApbE family; Region: ApbE; pfam02424
526218002243	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
526218002244	SLBB domain; Region: SLBB; pfam10531
526218002245	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
526218002246	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
526218002247	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
526218002248	active site turn [active]
526218002249	phosphorylation site [posttranslational modification]
526218002250	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
526218002251	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
526218002252	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
526218002253	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
526218002254	metal binding site [ion binding]; metal-binding site
526218002255	substrate binding pocket [chemical binding]; other site
526218002256	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
526218002257	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526218002258	DNA-binding site [nucleotide binding]; DNA binding site
526218002259	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
526218002260	Domain of unknown function (DUF333); Region: DUF333; pfam03891
526218002261	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
526218002262	Protein of unknown function (DUF454); Region: DUF454; cl01063
526218002263	Autotransporter beta-domain; Region: Autotransporter; smart00869
526218002264	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526218002265	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
526218002266	active site
526218002267	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
526218002268	tRNA 2-selenouridine synthase; Region: tRNA_sel_U_synt; TIGR03167
526218002269	active site residue [active]
526218002270	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218002271	Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295
526218002272	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218002273	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218002274	Adhesion protein FadA; Region: FadA; pfam09403
526218002275	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
526218002276	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
526218002277	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
526218002278	ligand binding site [chemical binding]; other site
526218002279	Methyltransferase domain; Region: Methyltransf_31; pfam13847
526218002280	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526218002281	S-adenosylmethionine binding site [chemical binding]; other site
526218002282	DKNYY family; Region: DKNYY; pfam13644
526218002283	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
526218002284	catalytic core [active]
526218002285	cobalamin synthase; Reviewed; Region: cobS; PRK00235
526218002286	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
526218002287	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
526218002288	putative active site [active]
526218002289	cobalt transport protein CbiM; Validated; Region: PRK08319
526218002290	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
526218002291	cobalt transport protein CbiN; Provisional; Region: PRK02898
526218002292	Cobalt transport protein; Region: CbiQ; cl00463
526218002293	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13639
526218002294	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
526218002295	Walker A/P-loop; other site
526218002296	ATP binding site [chemical binding]; other site
526218002297	Q-loop/lid; other site
526218002298	ABC transporter signature motif; other site
526218002299	Walker B; other site
526218002300	D-loop; other site
526218002301	H-loop/switch region; other site
526218002302	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
526218002303	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
526218002304	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
526218002305	catalytic triad [active]
526218002306	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
526218002307	Precorrin-8X methylmutase; Region: CbiC; pfam02570
526218002308	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
526218002309	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
526218002310	active site
526218002311	putative homodimer interface [polypeptide binding]; other site
526218002312	SAM binding site [chemical binding]; other site
526218002313	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
526218002314	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526218002315	S-adenosylmethionine binding site [chemical binding]; other site
526218002316	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
526218002317	active site
526218002318	SAM binding site [chemical binding]; other site
526218002319	homodimer interface [polypeptide binding]; other site
526218002320	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
526218002321	active site
526218002322	SAM binding site [chemical binding]; other site
526218002323	homodimer interface [polypeptide binding]; other site
526218002324	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
526218002325	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
526218002326	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
526218002327	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
526218002328	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
526218002329	active site
526218002330	SAM binding site [chemical binding]; other site
526218002331	homodimer interface [polypeptide binding]; other site
526218002332	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
526218002333	homotrimer interface [polypeptide binding]; other site
526218002334	Walker A motif; other site
526218002335	GTP binding site [chemical binding]; other site
526218002336	Walker B motif; other site
526218002337	cobyric acid synthase; Provisional; Region: PRK00784
526218002338	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
526218002339	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
526218002340	catalytic triad [active]
526218002341	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
526218002342	threonine-phosphate decarboxylase; Provisional; Region: PRK06358
526218002343	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
526218002344	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526218002345	homodimer interface [polypeptide binding]; other site
526218002346	catalytic residue [active]
526218002347	Glutamyl-tRNA reductase [Coenzyme metabolism]; Region: HemA; COG0373
526218002348	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
526218002349	tRNA; other site
526218002350	putative tRNA binding site [nucleotide binding]; other site
526218002351	putative NADP binding site [chemical binding]; other site
526218002352	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
526218002353	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
526218002354	domain interfaces; other site
526218002355	active site
526218002356	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
526218002357	active site
526218002358	SAM binding site [chemical binding]; other site
526218002359	homodimer interface [polypeptide binding]; other site
526218002360	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
526218002361	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
526218002362	active site
526218002363	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
526218002364	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
526218002365	inhibitor-cofactor binding pocket; inhibition site
526218002366	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526218002367	catalytic residue [active]
526218002368	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
526218002369	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
526218002370	putative dimer interface [polypeptide binding]; other site
526218002371	active site pocket [active]
526218002372	putative cataytic base [active]
526218002373	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
526218002374	catalytic core [active]
526218002375	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
526218002376	dimer interface [polypeptide binding]; other site
526218002377	active site
526218002378	Schiff base residues; other site
526218002379	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
526218002380	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
526218002381	ribosomal protein S1; Region: rpsA; TIGR00717
526218002382	Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutL; COG4816
526218002383	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047
526218002384	putative hexamer interface [polypeptide binding]; other site
526218002385	putative hexagonal pore; other site
526218002386	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048
526218002387	putative hexamer interface [polypeptide binding]; other site
526218002388	putative hexagonal pore; other site
526218002389	Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909
526218002390	Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687
526218002391	alpha-alpha subunit/dimer interface [polypeptide binding]; other site
526218002392	alpha-beta subunit interface [polypeptide binding]; other site
526218002393	alpha-gamma subunit interface [polypeptide binding]; other site
526218002394	active site
526218002395	substrate and K+ binding site; other site
526218002396	K+ binding site [ion binding]; other site
526218002397	cobalamin binding site [chemical binding]; other site
526218002398	propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042
526218002399	propanediol dehydratase small subunit; Provisional; Region: pduE; PRK15443
526218002400	Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841
526218002401	Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288
526218002402	Domain of unknown function (DUF336); Region: DUF336; pfam03928
526218002403	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
526218002404	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
526218002405	putative catalytic cysteine [active]
526218002406	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
526218002407	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
526218002408	Hexamer interface [polypeptide binding]; other site
526218002409	Putative hexagonal pore residue; other site
526218002410	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
526218002411	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
526218002412	Hexamer interface [polypeptide binding]; other site
526218002413	Putative hexagonal pore residue; other site
526218002414	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
526218002415	putative hexamer interface [polypeptide binding]; other site
526218002416	putative hexagonal pore; other site
526218002417	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
526218002418	G1 box; other site
526218002419	GTP/Mg2+ binding site [chemical binding]; other site
526218002420	Switch I region; other site
526218002421	G3 box; other site
526218002422	Switch II region; other site
526218002423	G4 box; other site
526218002424	G5 box; other site
526218002425	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
526218002426	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
526218002427	Hexamer interface [polypeptide binding]; other site
526218002428	Hexagonal pore residue; other site
526218002429	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
526218002430	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
526218002431	Hexamer interface [polypeptide binding]; other site
526218002432	Putative hexagonal pore residue; other site
526218002433	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
526218002434	putative catalytic cysteine [active]
526218002435	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
526218002436	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
526218002437	Propanediol utilisation protein PduL; Region: PduL; pfam06130
526218002438	Propanediol utilisation protein PduL; Region: PduL; pfam06130
526218002439	ethanolamine utilization protein; Region: eut_hyp; TIGR02536
526218002440	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
526218002441	Hexamer/Pentamer interface [polypeptide binding]; other site
526218002442	central pore; other site
526218002443	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
526218002444	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
526218002445	active site
526218002446	NAD binding site [chemical binding]; other site
526218002447	metal binding site [ion binding]; metal-binding site
526218002448	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
526218002449	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526218002450	active site
526218002451	phosphorylation site [posttranslational modification]
526218002452	intermolecular recognition site; other site
526218002453	dimerization interface [polypeptide binding]; other site
526218002454	ANTAR domain; Region: ANTAR; pfam03861
526218002455	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
526218002456	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
526218002457	Histidine kinase; Region: HisKA_2; pfam07568
526218002458	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526218002459	ATP binding site [chemical binding]; other site
526218002460	Mg2+ binding site [ion binding]; other site
526218002461	G-X-G motif; other site
526218002462	reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719
526218002463	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
526218002464	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
526218002465	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
526218002466	ethanolamine utilization protein EutL; Provisional; Region: PRK15405
526218002467	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049
526218002468	putative hexamer interface [polypeptide binding]; other site
526218002469	putative hexagonal pore; other site
526218002470	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050
526218002471	putative hexamer interface [polypeptide binding]; other site
526218002472	putative hexagonal pore; other site
526218002473	Ethanolamine utilisation protein, EutH; Region: EutH; pfam04346
526218002474	Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249
526218002475	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
526218002476	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
526218002477	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
526218002478	Autotransporter beta-domain; Region: Autotransporter; smart00869
526218002479	sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384
526218002480	Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322
526218002481	putative NAD(P) binding site [chemical binding]; other site
526218002482	active site
526218002483	Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732
526218002484	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
526218002485	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
526218002486	PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608
526218002487	Glucitol operon activator protein (GutM); Region: GutM; pfam06923
526218002488	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
526218002489	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
526218002490	dimer interface [polypeptide binding]; other site
526218002491	active site
526218002492	metal binding site [ion binding]; metal-binding site
526218002493	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
526218002494	active site
526218002495	intersubunit interactions; other site
526218002496	catalytic residue [active]
526218002497	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
526218002498	MarR family; Region: MarR_2; pfam12802
526218002499	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
526218002500	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
526218002501	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
526218002502	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
526218002503	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
526218002504	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
526218002505	non-specific DNA interactions [nucleotide binding]; other site
526218002506	DNA binding site [nucleotide binding]
526218002507	sequence specific DNA binding site [nucleotide binding]; other site
526218002508	putative cAMP binding site [chemical binding]; other site
526218002509	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
526218002510	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
526218002511	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
526218002512	Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264
526218002513	active site turn [active]
526218002514	phosphorylation site [posttranslational modification]
526218002515	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
526218002516	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
526218002517	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
526218002518	dimer interface [polypeptide binding]; other site
526218002519	active site
526218002520	glycine loop; other site
526218002521	flavoprotein, HI0933 family; Region: TIGR00275
526218002522	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
526218002523	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
526218002524	Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962
526218002525	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
526218002526	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
526218002527	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
526218002528	dimer interface [polypeptide binding]; other site
526218002529	catalytic triad [active]
526218002530	peroxidatic and resolving cysteines [active]
526218002531	Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848
526218002532	catalytic triad [active]
526218002533	putative active site [active]
526218002534	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
526218002535	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218002536	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526218002537	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
526218002538	active site
526218002539	motif I; other site
526218002540	motif II; other site
526218002541	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526218002542	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
526218002543	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
526218002544	dimerization interface [polypeptide binding]; other site
526218002545	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
526218002546	dimer interface [polypeptide binding]; other site
526218002547	phosphorylation site [posttranslational modification]
526218002548	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526218002549	ATP binding site [chemical binding]; other site
526218002550	Mg2+ binding site [ion binding]; other site
526218002551	G-X-G motif; other site
526218002552	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
526218002553	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526218002554	active site
526218002555	phosphorylation site [posttranslational modification]
526218002556	intermolecular recognition site; other site
526218002557	dimerization interface [polypeptide binding]; other site
526218002558	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
526218002559	DNA binding site [nucleotide binding]
526218002560	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
526218002561	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
526218002562	RNA binding surface [nucleotide binding]; other site
526218002563	oligoendopeptidase F; Region: pepF; TIGR00181
526218002564	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
526218002565	active site
526218002566	Zn binding site [ion binding]; other site
526218002567	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162
526218002568	HPr interaction site; other site
526218002569	glycerol kinase (GK) interaction site [polypeptide binding]; other site
526218002570	active site
526218002571	phosphorylation site [posttranslational modification]
526218002572	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
526218002573	Type III pantothenate kinase; Region: Pan_kinase; cl17198
526218002574	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
526218002575	Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei  (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_3; cd08975
526218002576	putative DNA binding site [nucleotide binding]; other site
526218002577	catalytic residue [active]
526218002578	putative H2TH interface [polypeptide binding]; other site
526218002579	putative catalytic residues [active]
526218002580	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
526218002581	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
526218002582	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
526218002583	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
526218002584	active site residue [active]
526218002585	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
526218002586	active site residue [active]
526218002587	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
526218002588	classical (c) SDRs; Region: SDR_c; cd05233
526218002589	NAD(P) binding site [chemical binding]; other site
526218002590	active site
526218002591	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
526218002592	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
526218002593	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
526218002594	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
526218002595	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412
526218002596	tetrameric interface [polypeptide binding]; other site
526218002597	activator binding site; other site
526218002598	NADP binding site [chemical binding]; other site
526218002599	substrate binding site [chemical binding]; other site
526218002600	catalytic residues [active]
526218002601	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
526218002602	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
526218002603	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
526218002604	catalytic residue [active]
526218002605	biotin synthase; Provisional; Region: PRK07094
526218002606	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526218002607	FeS/SAM binding site; other site
526218002608	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
526218002609	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
526218002610	Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187
526218002611	catalytic residue [active]
526218002612	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
526218002613	peroxiredoxin; Region: AhpC; TIGR03137
526218002614	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
526218002615	dimer interface [polypeptide binding]; other site
526218002616	decamer (pentamer of dimers) interface [polypeptide binding]; other site
526218002617	catalytic triad [active]
526218002618	peroxidatic and resolving cysteines [active]
526218002619	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
526218002620	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
526218002621	nucleotide binding site [chemical binding]; other site
526218002622	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
526218002623	polyphosphate kinase; Provisional; Region: PRK05443
526218002624	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
526218002625	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
526218002626	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
526218002627	putative domain interface [polypeptide binding]; other site
526218002628	putative active site [active]
526218002629	catalytic site [active]
526218002630	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
526218002631	putative domain interface [polypeptide binding]; other site
526218002632	putative active site [active]
526218002633	catalytic site [active]
526218002634	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
526218002635	VanW like protein; Region: VanW; pfam04294
526218002636	G5 domain; Region: G5; pfam07501
526218002637	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
526218002638	EamA-like transporter family; Region: EamA; pfam00892
526218002639	EamA-like transporter family; Region: EamA; pfam00892
526218002640	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
526218002641	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
526218002642	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526218002643	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
526218002644	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
526218002645	DNA binding site [nucleotide binding]
526218002646	active site
526218002647	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
526218002648	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
526218002649	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
526218002650	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
526218002651	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
526218002652	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
526218002653	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
526218002654	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
526218002655	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
526218002656	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
526218002657	Substrate-binding site [chemical binding]; other site
526218002658	Substrate specificity [chemical binding]; other site
526218002659	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
526218002660	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
526218002661	active site
526218002662	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
526218002663	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
526218002664	Walker A/P-loop; other site
526218002665	ATP binding site [chemical binding]; other site
526218002666	Q-loop/lid; other site
526218002667	ABC transporter signature motif; other site
526218002668	Walker B; other site
526218002669	D-loop; other site
526218002670	H-loop/switch region; other site
526218002671	TOBE domain; Region: TOBE_2; pfam08402
526218002672	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
526218002673	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526218002674	dimer interface [polypeptide binding]; other site
526218002675	conserved gate region; other site
526218002676	putative PBP binding loops; other site
526218002677	ABC-ATPase subunit interface; other site
526218002678	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
526218002679	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526218002680	dimer interface [polypeptide binding]; other site
526218002681	conserved gate region; other site
526218002682	putative PBP binding loops; other site
526218002683	ABC-ATPase subunit interface; other site
526218002684	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
526218002685	DEAD-like helicases superfamily; Region: DEXDc; smart00487
526218002686	ATP binding site [chemical binding]; other site
526218002687	Mg++ binding site [ion binding]; other site
526218002688	motif III; other site
526218002689	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526218002690	nucleotide binding region [chemical binding]; other site
526218002691	ATP-binding site [chemical binding]; other site
526218002692	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
526218002693	RNA binding site [nucleotide binding]; other site
526218002694	triosephosphate isomerase; Provisional; Region: PRK14565
526218002695	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
526218002696	substrate binding site [chemical binding]; other site
526218002697	dimer interface [polypeptide binding]; other site
526218002698	catalytic triad [active]
526218002699	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
526218002700	phosphoglyceromutase; Provisional; Region: PRK05434
526218002701	recombination factor protein RarA; Reviewed; Region: PRK13342
526218002702	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526218002703	Walker A motif; other site
526218002704	ATP binding site [chemical binding]; other site
526218002705	Walker B motif; other site
526218002706	arginine finger; other site
526218002707	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
526218002708	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
526218002709	Domain of unknown function DUF21; Region: DUF21; pfam01595
526218002710	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
526218002711	Transporter associated domain; Region: CorC_HlyC; smart01091
526218002712	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
526218002713	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526218002714	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
526218002715	dimer interface [polypeptide binding]; other site
526218002716	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
526218002717	HAMP domain; Region: HAMP; pfam00672
526218002718	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
526218002719	dimer interface [polypeptide binding]; other site
526218002720	phosphorylation site [posttranslational modification]
526218002721	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526218002722	ATP binding site [chemical binding]; other site
526218002723	Mg2+ binding site [ion binding]; other site
526218002724	G-X-G motif; other site
526218002725	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
526218002726	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526218002727	active site
526218002728	phosphorylation site [posttranslational modification]
526218002729	intermolecular recognition site; other site
526218002730	dimerization interface [polypeptide binding]; other site
526218002731	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
526218002732	DNA binding site [nucleotide binding]
526218002733	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
526218002734	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
526218002735	dimer interface [polypeptide binding]; other site
526218002736	motif 1; other site
526218002737	active site
526218002738	motif 2; other site
526218002739	motif 3; other site
526218002740	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
526218002741	anticodon binding site; other site
526218002742	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
526218002743	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
526218002744	dimer interface [polypeptide binding]; other site
526218002745	anticodon binding site; other site
526218002746	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
526218002747	homodimer interface [polypeptide binding]; other site
526218002748	motif 1; other site
526218002749	active site
526218002750	motif 2; other site
526218002751	GAD domain; Region: GAD; pfam02938
526218002752	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
526218002753	motif 3; other site
526218002754	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
526218002755	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
526218002756	Domain of unknown function (DUF4274); Region: DUF4274; pfam14096
526218002757	Predicted transcriptional regulators [Transcription]; Region: COG1733
526218002758	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
526218002759	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
526218002760	substrate binding site [chemical binding]; other site
526218002761	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
526218002762	Protein of unknown function (DUF1439); Region: DUF1439; cl06345
526218002763	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
526218002764	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
526218002765	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
526218002766	GIY-YIG motif/motif A; other site
526218002767	active site
526218002768	catalytic site [active]
526218002769	putative DNA binding site [nucleotide binding]; other site
526218002770	metal binding site [ion binding]; metal-binding site
526218002771	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
526218002772	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
526218002773	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
526218002774	Walker A/P-loop; other site
526218002775	ATP binding site [chemical binding]; other site
526218002776	Q-loop/lid; other site
526218002777	ABC transporter signature motif; other site
526218002778	Walker B; other site
526218002779	D-loop; other site
526218002780	H-loop/switch region; other site
526218002781	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
526218002782	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
526218002783	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
526218002784	TM-ABC transporter signature motif; other site
526218002785	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
526218002786	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
526218002787	TM-ABC transporter signature motif; other site
526218002788	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526218002789	non-specific DNA binding site [nucleotide binding]; other site
526218002790	salt bridge; other site
526218002791	sequence-specific DNA binding site [nucleotide binding]; other site
526218002792	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
526218002793	Catalytic site [active]
526218002794	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526218002795	non-specific DNA binding site [nucleotide binding]; other site
526218002796	salt bridge; other site
526218002797	sequence-specific DNA binding site [nucleotide binding]; other site
526218002798	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
526218002799	dimer interface [polypeptide binding]; other site
526218002800	substrate binding site [chemical binding]; other site
526218002801	ATP binding site [chemical binding]; other site
526218002802	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
526218002803	substrate binding site [chemical binding]; other site
526218002804	multimerization interface [polypeptide binding]; other site
526218002805	ATP binding site [chemical binding]; other site
526218002806	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
526218002807	thiamine phosphate binding site [chemical binding]; other site
526218002808	active site
526218002809	pyrophosphate binding site [ion binding]; other site
526218002810	Putative transcription activator [Transcription]; Region: TenA; COG0819
526218002811	Helix-turn-helix domain; Region: HTH_17; pfam12728
526218002812	PBP superfamily domain; Region: PBP_like; pfam12727
526218002813	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
526218002814	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526218002815	dimer interface [polypeptide binding]; other site
526218002816	conserved gate region; other site
526218002817	putative PBP binding loops; other site
526218002818	ABC-ATPase subunit interface; other site
526218002819	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
526218002820	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
526218002821	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
526218002822	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
526218002823	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
526218002824	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
526218002825	23S rRNA binding site [nucleotide binding]; other site
526218002826	L21 binding site [polypeptide binding]; other site
526218002827	L13 binding site [polypeptide binding]; other site
526218002828	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
526218002829	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
526218002830	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
526218002831	rod shape-determining protein MreB; Provisional; Region: PRK13927
526218002832	MreB and similar proteins; Region: MreB_like; cd10225
526218002833	nucleotide binding site [chemical binding]; other site
526218002834	Mg binding site [ion binding]; other site
526218002835	putative protofilament interaction site [polypeptide binding]; other site
526218002836	RodZ interaction site [polypeptide binding]; other site
526218002837	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
526218002838	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
526218002839	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
526218002840	RNA binding surface [nucleotide binding]; other site
526218002841	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
526218002842	active site
526218002843	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
526218002844	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
526218002845	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
526218002846	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
526218002847	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
526218002848	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
526218002849	GatB domain; Region: GatB_Yqey; pfam02637
526218002850	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
526218002851	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
526218002852	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
526218002853	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
526218002854	primosome assembly protein PriA; Validated; Region: PRK05580
526218002855	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526218002856	ATP binding site [chemical binding]; other site
526218002857	putative Mg++ binding site [ion binding]; other site
526218002858	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526218002859	ATP-binding site [chemical binding]; other site
526218002860	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
526218002861	active site
526218002862	catalytic residues [active]
526218002863	metal binding site [ion binding]; metal-binding site
526218002864	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
526218002865	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
526218002866	putative active site [active]
526218002867	substrate binding site [chemical binding]; other site
526218002868	putative cosubstrate binding site; other site
526218002869	catalytic site [active]
526218002870	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
526218002871	substrate binding site [chemical binding]; other site
526218002872	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
526218002873	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
526218002874	CoA binding domain; Region: CoA_binding; cl17356
526218002875	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
526218002876	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
526218002877	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
526218002878	homodimer interface [polypeptide binding]; other site
526218002879	NADP binding site [chemical binding]; other site
526218002880	substrate binding site [chemical binding]; other site
526218002881	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
526218002882	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
526218002883	carboxyltransferase (CT) interaction site; other site
526218002884	biotinylation site [posttranslational modification]; other site
526218002885	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
526218002886	active site
526218002887	multimer interface [polypeptide binding]; other site
526218002888	FOG: CBS domain [General function prediction only]; Region: COG0517
526218002889	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
526218002890	Domain of unknown function DUF21; Region: DUF21; pfam01595
526218002891	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
526218002892	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
526218002893	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
526218002894	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
526218002895	nudix motif; other site
526218002896	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
526218002897	active site
526218002898	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
526218002899	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
526218002900	Zn2+ binding site [ion binding]; other site
526218002901	Mg2+ binding site [ion binding]; other site
526218002902	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
526218002903	synthetase active site [active]
526218002904	NTP binding site [chemical binding]; other site
526218002905	metal binding site [ion binding]; metal-binding site
526218002906	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
526218002907	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
526218002908	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
526218002909	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
526218002910	YcxB-like protein; Region: YcxB; pfam14317
526218002911	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
526218002912	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526218002913	S-adenosylmethionine binding site [chemical binding]; other site
526218002914	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
526218002915	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
526218002916	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
526218002917	PhoU domain; Region: PhoU; pfam01895
526218002918	PhoU domain; Region: PhoU; pfam01895
526218002919	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
526218002920	putative catalytic site [active]
526218002921	putative metal binding site [ion binding]; other site
526218002922	putative phosphate binding site [ion binding]; other site
526218002923	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
526218002924	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
526218002925	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
526218002926	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
526218002927	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
526218002928	active site
526218002929	catalytic tetrad [active]
526218002930	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
526218002931	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
526218002932	active site
526218002933	trimer interface [polypeptide binding]; other site
526218002934	allosteric site; other site
526218002935	active site lid [active]
526218002936	hexamer (dimer of trimers) interface [polypeptide binding]; other site
526218002937	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
526218002938	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
526218002939	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
526218002940	active site
526218002941	P-loop; other site
526218002942	phosphorylation site [posttranslational modification]
526218002943	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
526218002944	methionine cluster; other site
526218002945	active site
526218002946	phosphorylation site [posttranslational modification]
526218002947	metal binding site [ion binding]; metal-binding site
526218002948	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
526218002949	HTH domain; Region: HTH_11; pfam08279
526218002950	PRD domain; Region: PRD; pfam00874
526218002951	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
526218002952	active site
526218002953	P-loop; other site
526218002954	phosphorylation site [posttranslational modification]
526218002955	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218002956	active site
526218002957	phosphorylation site [posttranslational modification]
526218002958	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
526218002959	HSP70 interaction site [polypeptide binding]; other site
526218002960	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
526218002961	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
526218002962	phosphopeptide binding site; other site
526218002963	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
526218002964	phosphopeptide binding site; other site
526218002965	Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631
526218002966	active site
526218002967	Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631
526218002968	active site
526218002969	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
526218002970	Catalytic domain of Protein Kinases; Region: PKc; cd00180
526218002971	active site
526218002972	ATP binding site [chemical binding]; other site
526218002973	substrate binding site [chemical binding]; other site
526218002974	activation loop (A-loop); other site
526218002975	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
526218002976	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
526218002977	ThiC family; Region: ThiC; cl08031
526218002978	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
526218002979	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
526218002980	binding surface
526218002981	TPR motif; other site
526218002982	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
526218002983	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
526218002984	HlyD family secretion protein; Region: HlyD_3; pfam13437
526218002985	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
526218002986	YibE/F-like protein; Region: YibE_F; cl02259
526218002987	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
526218002988	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
526218002989	Peptidase family M23; Region: Peptidase_M23; pfam01551
526218002990	hypothetical protein; Provisional; Region: PRK10621
526218002991	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
526218002992	excinuclease ABC subunit B; Provisional; Region: PRK05298
526218002993	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526218002994	ATP binding site [chemical binding]; other site
526218002995	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526218002996	nucleotide binding region [chemical binding]; other site
526218002997	ATP-binding site [chemical binding]; other site
526218002998	Ultra-violet resistance protein B; Region: UvrB; pfam12344
526218002999	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
526218003000	ArsC family; Region: ArsC; pfam03960
526218003001	putative ArsC-like catalytic residues; other site
526218003002	putative TRX-like catalytic residues [active]
526218003003	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
526218003004	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
526218003005	generic binding surface II; other site
526218003006	generic binding surface I; other site
526218003007	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218003008	binding surface
526218003009	TPR motif; other site
526218003010	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cl07889
526218003011	DNA protecting protein DprA; Region: dprA; TIGR00732
526218003012	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
526218003013	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
526218003014	Resolvase, N terminal domain; Region: Resolvase; smart00857
526218003015	catalytic residues [active]
526218003016	catalytic nucleophile [active]
526218003017	Recombinase; Region: Recombinase; pfam07508
526218003018	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
526218003019	RecT family; Region: RecT; pfam03837
526218003020	Protein of unknown function (DUF1351); Region: DUF1351; pfam07083
526218003021	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
526218003022	Catalytic site [active]
526218003023	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
526218003024	Catalytic domain of Protein Kinases; Region: PKc; cd00180
526218003025	active site
526218003026	ATP binding site [chemical binding]; other site
526218003027	substrate binding site [chemical binding]; other site
526218003028	activation loop (A-loop); other site
526218003029	replicative DNA helicase; Region: DnaB; TIGR00665
526218003030	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
526218003031	Walker A motif; other site
526218003032	ATP binding site [chemical binding]; other site
526218003033	Walker B motif; other site
526218003034	Protein of unknown function (DUF968); Region: DUF968; pfam06147
526218003035	DKNYY family; Region: DKNYY; pfam13644
526218003036	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
526218003037	Phage terminase large subunit; Region: Terminase_3; cl12054
526218003038	Protein of unknown function (DUF935); Region: DUF935; pfam06074
526218003039	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
526218003040	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
526218003041	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
526218003042	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
526218003043	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
526218003044	active site
526218003045	metal binding site [ion binding]; metal-binding site
526218003046	Holin family; Region: Phage_holin_4; pfam05105
526218003047	Domain of unknown function (DUF4297); Region: DUF4297; pfam14130
526218003048	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526218003049	MarR family; Region: MarR; pfam01047
526218003050	MarR family; Region: MarR_2; cl17246
526218003051	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
526218003052	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
526218003053	SCP-2 sterol transfer family; Region: SCP2; pfam02036
526218003054	Predicted membrane protein [Function unknown]; Region: COG2323
526218003055	Protein of unknown function (DUF3290); Region: DUF3290; pfam11694
526218003056	Predicted permeases [General function prediction only]; Region: COG0701
526218003057	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
526218003058	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526218003059	dimerization interface [polypeptide binding]; other site
526218003060	putative DNA binding site [nucleotide binding]; other site
526218003061	putative Zn2+ binding site [ion binding]; other site
526218003062	C_GCAxxG_C_C family probable redox protein; Region: C_GCAxxG_C_C; TIGR01909
526218003063	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
526218003064	Sodium Bile acid symporter family; Region: SBF; cl17470
526218003065	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
526218003066	Low molecular weight phosphatase family; Region: LMWPc; cl00105
526218003067	active site
526218003068	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
526218003069	DKNYY family; Region: DKNYY; pfam13644
526218003070	Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280
526218003071	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
526218003072	NADP binding site [chemical binding]; other site
526218003073	dimer interface [polypeptide binding]; other site
526218003074	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526218003075	MarR family; Region: MarR_2; pfam12802
526218003076	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
526218003077	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526218003078	AAA domain; Region: AAA_21; pfam13304
526218003079	Walker A/P-loop; other site
526218003080	ATP binding site [chemical binding]; other site
526218003081	Protein of unknown function (DUF3696); Region: DUF3696; pfam12476
526218003082	Helix-turn-helix; Region: HTH_3; pfam01381
526218003083	non-specific DNA binding site [nucleotide binding]; other site
526218003084	salt bridge; other site
526218003085	sequence-specific DNA binding site [nucleotide binding]; other site
526218003086	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218003087	TPR motif; other site
526218003088	binding surface
526218003089	Tetratricopeptide repeat; Region: TPR_16; pfam13432
526218003090	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218003091	TPR repeat; Region: TPR_11; pfam13414
526218003092	binding surface
526218003093	TPR motif; other site
526218003094	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218003095	binding surface
526218003096	TPR motif; other site
526218003097	TPR repeat; Region: TPR_11; pfam13414
526218003098	TPR repeat; Region: TPR_11; pfam13414
526218003099	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218003100	binding surface
526218003101	TPR motif; other site
526218003102	TPR repeat; Region: TPR_11; pfam13414
526218003103	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218003104	binding surface
526218003105	TPR motif; other site
526218003106	TPR repeat; Region: TPR_11; pfam13414
526218003107	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218003108	Tetratricopeptide repeat; Region: TPR_12; pfam13424
526218003109	binding surface
526218003110	TPR motif; other site
526218003111	Prophage antirepressor [Transcription]; Region: COG3617
526218003112	BRO family, N-terminal domain; Region: Bro-N; smart01040
526218003113	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
526218003114	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
526218003115	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
526218003116	active site
526218003117	catalytic tetrad [active]
526218003118	Cupin domain; Region: Cupin_2; cl17218
526218003119	MarR family; Region: MarR_2; pfam12802
526218003120	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
526218003121	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
526218003122	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526218003123	Coenzyme A binding pocket [chemical binding]; other site
526218003124	DKNYY family; Region: DKNYY; pfam13644
526218003125	Protein of unknown function (DUF1062); Region: DUF1062; cl01786
526218003126	Uncharacterized conserved protein [Function unknown]; Region: COG1434
526218003127	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
526218003128	putative active site [active]
526218003129	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526218003130	MarR family; Region: MarR; pfam01047
526218003131	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
526218003132	EamA-like transporter family; Region: EamA; pfam00892
526218003133	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
526218003134	EamA-like transporter family; Region: EamA; pfam00892
526218003135	Domain of unknown function (DUF4280); Region: DUF4280; pfam14107
526218003136	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
526218003137	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
526218003138	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
526218003139	Predicted transcriptional regulators [Transcription]; Region: COG1733
526218003140	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
526218003141	TIGR04076 family protein; Region: TIGR04076
526218003142	Cupin domain; Region: Cupin_2; cl17218
526218003143	Helix-turn-helix domain; Region: HTH_18; pfam12833
526218003144	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526218003145	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
526218003146	Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101
526218003147	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
526218003148	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
526218003149	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526218003150	NAD(P) binding site [chemical binding]; other site
526218003151	active site
526218003152	TPR repeat; Region: TPR_11; pfam13414
526218003153	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218003154	binding surface
526218003155	TPR motif; other site
526218003156	Tetratricopeptide repeat; Region: TPR_16; pfam13432
526218003157	YcxB-like protein; Region: YcxB; pfam14317
526218003158	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
526218003159	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
526218003160	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526218003161	motif II; other site
526218003162	Predicted esterase [General function prediction only]; Region: COG0627
526218003163	S-formylglutathione hydrolase; Region: PLN02442
526218003164	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
526218003165	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218003166	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
526218003167	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
526218003168	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
526218003169	Ca binding site [ion binding]; other site
526218003170	active site
526218003171	catalytic site [active]
526218003172	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
526218003173	dimer interface [polypeptide binding]; other site
526218003174	putative tRNA-binding site [nucleotide binding]; other site
526218003175	Domain of unknown function (DUF4303); Region: DUF4303; pfam14136
526218003176	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
526218003177	Clp amino terminal domain; Region: Clp_N; pfam02861
526218003178	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526218003179	Walker A motif; other site
526218003180	ATP binding site [chemical binding]; other site
526218003181	Walker B motif; other site
526218003182	arginine finger; other site
526218003183	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526218003184	Walker A motif; other site
526218003185	ATP binding site [chemical binding]; other site
526218003186	Walker B motif; other site
526218003187	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
526218003188	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
526218003189	PRD domain; Region: PRD; pfam00874
526218003190	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
526218003191	active site
526218003192	P-loop; other site
526218003193	phosphorylation site [posttranslational modification]
526218003194	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218003195	active site
526218003196	phosphorylation site [posttranslational modification]
526218003197	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
526218003198	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
526218003199	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
526218003200	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
526218003201	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
526218003202	active site
526218003203	catalytic residues [active]
526218003204	DNA binding site [nucleotide binding]
526218003205	Int/Topo IB signature motif; other site
526218003206	Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561
526218003207	Domain of unknown function (DUF955); Region: DUF955; pfam06114
526218003208	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
526218003209	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526218003210	non-specific DNA binding site [nucleotide binding]; other site
526218003211	salt bridge; other site
526218003212	sequence-specific DNA binding site [nucleotide binding]; other site
526218003213	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526218003214	non-specific DNA binding site [nucleotide binding]; other site
526218003215	salt bridge; other site
526218003216	sequence-specific DNA binding site [nucleotide binding]; other site
526218003217	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
526218003218	putative DNA binding site [nucleotide binding]; other site
526218003219	putative Zn2+ binding site [ion binding]; other site
526218003220	Helix-turn-helix domain; Region: HTH_17; cl17695
526218003221	Transcription factor Tfb2; Region: Tfb2; cl04289
526218003222	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
526218003223	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526218003224	non-specific DNA binding site [nucleotide binding]; other site
526218003225	salt bridge; other site
526218003226	sequence-specific DNA binding site [nucleotide binding]; other site
526218003227	Protein of unknown function (DUF2800); Region: DUF2800; pfam10926
526218003228	Protein of unknown function (DUF2815); Region: DUF2815; pfam10991
526218003229	Virulence-associated protein E; Region: VirE; pfam05272
526218003230	VRR-NUC domain; Region: VRR_NUC; pfam08774
526218003231	DEAD-like helicases superfamily; Region: DEXDc; smart00487
526218003232	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526218003233	ATP binding site [chemical binding]; other site
526218003234	putative Mg++ binding site [ion binding]; other site
526218003235	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
526218003236	nucleotide binding region [chemical binding]; other site
526218003237	ATP-binding site [chemical binding]; other site
526218003238	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
526218003239	L-aminoadipate-semialdehyde dehydrogenase; Region: alpha_am_amid; TIGR03443
526218003240	Terminase small subunit; Region: Terminase_2; pfam03592
526218003241	Phage terminase large subunit; Region: Terminase_3; cl12054
526218003242	Terminase-like family; Region: Terminase_6; pfam03237
526218003243	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
526218003244	phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538
526218003245	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
526218003246	Phage minor structural protein GP20; Region: Phage_GP20; pfam06810
526218003247	Phage tail sheath protein; Region: Phage_sheath_1; pfam04984
526218003248	Protein of unknown function (DUF2001); Region: DUF2001; pfam09393
526218003249	Phage XkdN-like protein; Region: XkdN; pfam08890
526218003250	tape measure domain; Region: tape_meas_nterm; TIGR02675
526218003251	Protein of unknown function (DUF2577); Region: DUF2577; pfam10844
526218003252	Protein of unknown function (DUF2634); Region: DUF2634; pfam10934
526218003253	Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299
526218003254	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542
526218003255	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
526218003256	amidase catalytic site [active]
526218003257	Zn binding residues [ion binding]; other site
526218003258	substrate binding site [chemical binding]; other site
526218003259	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
526218003260	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
526218003261	putative substrate binding site [chemical binding]; other site
526218003262	putative ATP binding site [chemical binding]; other site
526218003263	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
526218003264	active site
526218003265	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
526218003266	substrate binding site [chemical binding]; other site
526218003267	metal binding site [ion binding]; metal-binding site
526218003268	DKNYY family; Region: DKNYY; pfam13644
526218003269	alpha-mannosidase; Provisional; Region: PRK09819
526218003270	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
526218003271	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
526218003272	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
526218003273	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
526218003274	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
526218003275	active site
526218003276	P-loop; other site
526218003277	phosphorylation site [posttranslational modification]
526218003278	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218003279	active site
526218003280	phosphorylation site [posttranslational modification]
526218003281	Initiator Replication protein; Region: Rep_3; pfam01051
526218003282	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218003283	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
526218003284	HTH domain; Region: HTH_11; cl17392
526218003285	PRD domain; Region: PRD; pfam00874
526218003286	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
526218003287	active site
526218003288	P-loop; other site
526218003289	phosphorylation site [posttranslational modification]
526218003290	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218003291	active site
526218003292	phosphorylation site [posttranslational modification]
526218003293	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218003294	active site
526218003295	phosphorylation site [posttranslational modification]
526218003296	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
526218003297	active site
526218003298	P-loop; other site
526218003299	phosphorylation site [posttranslational modification]
526218003300	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
526218003301	transketolase; Reviewed; Region: PRK05899
526218003302	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
526218003303	TPP-binding site [chemical binding]; other site
526218003304	dimer interface [polypeptide binding]; other site
526218003305	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
526218003306	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
526218003307	PYR/PP interface [polypeptide binding]; other site
526218003308	dimer interface [polypeptide binding]; other site
526218003309	TPP binding site [chemical binding]; other site
526218003310	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
526218003311	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218003312	Predicted transcriptional regulators [Transcription]; Region: COG1733
526218003313	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
526218003314	Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139
526218003315	putative FMN binding site [chemical binding]; other site
526218003316	Domain of unknown function (DUF4280); Region: DUF4280; pfam14107
526218003317	DKNYY family; Region: DKNYY; pfam13644
526218003318	DKNYY family; Region: DKNYY; pfam13644
526218003319	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
526218003320	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
526218003321	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
526218003322	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
526218003323	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
526218003324	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
526218003325	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
526218003326	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
526218003327	Walker A/P-loop; other site
526218003328	ATP binding site [chemical binding]; other site
526218003329	Q-loop/lid; other site
526218003330	ABC transporter signature motif; other site
526218003331	Walker B; other site
526218003332	D-loop; other site
526218003333	H-loop/switch region; other site
526218003334	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
526218003335	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
526218003336	Walker A/P-loop; other site
526218003337	ATP binding site [chemical binding]; other site
526218003338	Q-loop/lid; other site
526218003339	ABC transporter signature motif; other site
526218003340	Walker B; other site
526218003341	D-loop; other site
526218003342	H-loop/switch region; other site
526218003343	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
526218003344	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
526218003345	HlyD family secretion protein; Region: HlyD_3; pfam13437
526218003346	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
526218003347	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526218003348	MarR family; Region: MarR_2; pfam12802
526218003349	Protein of unknown function (DUF1275); Region: DUF1275; cl01453
526218003350	Transcriptional regulators [Transcription]; Region: PurR; COG1609
526218003351	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
526218003352	DNA binding site [nucleotide binding]
526218003353	domain linker motif; other site
526218003354	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
526218003355	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
526218003356	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
526218003357	DNA interaction; other site
526218003358	Metal-binding active site; metal-binding site
526218003359	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
526218003360	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
526218003361	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
526218003362	ligand binding site [chemical binding]; other site
526218003363	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
526218003364	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
526218003365	Walker A/P-loop; other site
526218003366	ATP binding site [chemical binding]; other site
526218003367	Q-loop/lid; other site
526218003368	ABC transporter signature motif; other site
526218003369	Walker B; other site
526218003370	D-loop; other site
526218003371	H-loop/switch region; other site
526218003372	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
526218003373	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
526218003374	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
526218003375	TM-ABC transporter signature motif; other site
526218003376	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
526218003377	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526218003378	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
526218003379	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
526218003380	DKNYY family; Region: DKNYY; pfam13644
526218003381	DKNYY family; Region: DKNYY; pfam13644
526218003382	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526218003383	MarR family; Region: MarR_2; pfam12802
526218003384	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
526218003385	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
526218003386	DKNYY family; Region: DKNYY; pfam13644
526218003387	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
526218003388	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
526218003389	Tetratricopeptide repeat; Region: TPR_12; pfam13424
526218003390	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218003391	binding surface
526218003392	TPR motif; other site
526218003393	Tetratricopeptide repeat; Region: TPR_12; pfam13424
526218003394	Tetratricopeptide repeat; Region: TPR_12; pfam13424
526218003395	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218003396	binding surface
526218003397	TPR motif; other site
526218003398	TPR repeat; Region: TPR_11; pfam13414
526218003399	Domain of unknown function (DUF4280); Region: DUF4280; pfam14107
526218003400	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
526218003401	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
526218003402	dimer interface [polypeptide binding]; other site
526218003403	active site
526218003404	metal binding site [ion binding]; metal-binding site
526218003405	Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818
526218003406	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526218003407	Walker A/P-loop; other site
526218003408	ATP binding site [chemical binding]; other site
526218003409	Q-loop/lid; other site
526218003410	ABC transporter signature motif; other site
526218003411	Walker B; other site
526218003412	D-loop; other site
526218003413	H-loop/switch region; other site
526218003414	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
526218003415	homodimer interface [polypeptide binding]; other site
526218003416	chemical substrate binding site [chemical binding]; other site
526218003417	oligomer interface [polypeptide binding]; other site
526218003418	metal binding site [ion binding]; metal-binding site
526218003419	DKNYY family; Region: DKNYY; pfam13644
526218003420	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
526218003421	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526218003422	dimer interface [polypeptide binding]; other site
526218003423	conserved gate region; other site
526218003424	putative PBP binding loops; other site
526218003425	ABC-ATPase subunit interface; other site
526218003426	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
526218003427	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
526218003428	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
526218003429	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
526218003430	Walker A/P-loop; other site
526218003431	ATP binding site [chemical binding]; other site
526218003432	Q-loop/lid; other site
526218003433	ABC transporter signature motif; other site
526218003434	Walker B; other site
526218003435	D-loop; other site
526218003436	H-loop/switch region; other site
526218003437	FOG: CBS domain [General function prediction only]; Region: COG0517
526218003438	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
526218003439	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
526218003440	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
526218003441	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
526218003442	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
526218003443	putative catalytic cysteine [active]
526218003444	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
526218003445	putative active site [active]
526218003446	metal binding site [ion binding]; metal-binding site
526218003447	Autotransporter beta-domain; Region: Autotransporter; smart00869
526218003448	Transcriptional regulators [Transcription]; Region: PurR; COG1609
526218003449	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
526218003450	DNA binding site [nucleotide binding]
526218003451	domain linker motif; other site
526218003452	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
526218003453	dimerization interface [polypeptide binding]; other site
526218003454	ligand binding site [chemical binding]; other site
526218003455	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
526218003456	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
526218003457	Walker A/P-loop; other site
526218003458	ATP binding site [chemical binding]; other site
526218003459	Q-loop/lid; other site
526218003460	ABC transporter signature motif; other site
526218003461	Walker B; other site
526218003462	D-loop; other site
526218003463	H-loop/switch region; other site
526218003464	TOBE domain; Region: TOBE; pfam03459
526218003465	sucrose phosphorylase; Provisional; Region: PRK13840
526218003466	Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356
526218003467	active site
526218003468	homodimer interface [polypeptide binding]; other site
526218003469	catalytic site [active]
526218003470	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
526218003471	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
526218003472	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526218003473	dimer interface [polypeptide binding]; other site
526218003474	conserved gate region; other site
526218003475	putative PBP binding loops; other site
526218003476	ABC-ATPase subunit interface; other site
526218003477	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
526218003478	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526218003479	dimer interface [polypeptide binding]; other site
526218003480	conserved gate region; other site
526218003481	putative PBP binding loops; other site
526218003482	ABC-ATPase subunit interface; other site
526218003483	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
526218003484	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
526218003485	putative NAD(P) binding site [chemical binding]; other site
526218003486	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
526218003487	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
526218003488	Metal-binding active site; metal-binding site
526218003489	AP (apurinic/apyrimidinic) site pocket; other site
526218003490	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
526218003491	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526218003492	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
526218003493	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
526218003494	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
526218003495	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
526218003496	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
526218003497	beta-phosphoglucomutase; Region: bPGM; TIGR01990
526218003498	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526218003499	motif II; other site
526218003500	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
526218003501	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
526218003502	putative active site [active]
526218003503	putative FMN binding site [chemical binding]; other site
526218003504	putative substrate binding site [chemical binding]; other site
526218003505	putative catalytic residue [active]
526218003506	Right handed beta helix region; Region: Beta_helix; pfam13229
526218003507	Right handed beta helix region; Region: Beta_helix; pfam13229
526218003508	Right handed beta helix region; Region: Beta_helix; pfam13229
526218003509	Autotransporter beta-domain; Region: Autotransporter; smart00869
526218003510	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
526218003511	Predicted permeases [General function prediction only]; Region: COG0679
526218003512	Uncharacterized conserved protein related to pyruvate formate-lyase activating enzyme [General function prediction only]; Region: COG2108
526218003513	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
526218003514	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
526218003515	substrate binding pocket [chemical binding]; other site
526218003516	membrane-bound complex binding site; other site
526218003517	hinge residues; other site
526218003518	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
526218003519	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
526218003520	Walker A/P-loop; other site
526218003521	ATP binding site [chemical binding]; other site
526218003522	Q-loop/lid; other site
526218003523	ABC transporter signature motif; other site
526218003524	Walker B; other site
526218003525	D-loop; other site
526218003526	H-loop/switch region; other site
526218003527	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526218003528	dimer interface [polypeptide binding]; other site
526218003529	conserved gate region; other site
526218003530	ABC-ATPase subunit interface; other site
526218003531	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526218003532	dimer interface [polypeptide binding]; other site
526218003533	conserved gate region; other site
526218003534	putative PBP binding loops; other site
526218003535	ABC-ATPase subunit interface; other site
526218003536	Predicted transcriptional regulator [Transcription]; Region: COG1959
526218003537	Transcriptional regulator; Region: Rrf2; pfam02082
526218003538	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
526218003539	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526218003540	ATP binding site [chemical binding]; other site
526218003541	putative Mg++ binding site [ion binding]; other site
526218003542	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526218003543	nucleotide binding region [chemical binding]; other site
526218003544	ATP-binding site [chemical binding]; other site
526218003545	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
526218003546	HRDC domain; Region: HRDC; pfam00570
526218003547	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
526218003548	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
526218003549	glutaminase active site [active]
526218003550	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
526218003551	dimer interface [polypeptide binding]; other site
526218003552	active site
526218003553	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
526218003554	dimer interface [polypeptide binding]; other site
526218003555	active site
526218003556	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
526218003557	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
526218003558	TPP-binding site [chemical binding]; other site
526218003559	dimer interface [polypeptide binding]; other site
526218003560	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
526218003561	PYR/PP interface [polypeptide binding]; other site
526218003562	dimer interface [polypeptide binding]; other site
526218003563	TPP binding site [chemical binding]; other site
526218003564	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
526218003565	TPR repeat; Region: TPR_11; pfam13414
526218003566	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218003567	TPR motif; other site
526218003568	TPR repeat; Region: TPR_11; pfam13414
526218003569	binding surface
526218003570	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
526218003571	binding surface
526218003572	TPR motif; other site
526218003573	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
526218003574	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
526218003575	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
526218003576	Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600
526218003577	active site
526218003578	catalytic site [active]
526218003579	metal binding site [ion binding]; metal-binding site
526218003580	DKNYY family; Region: DKNYY; pfam13644
526218003581	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
526218003582	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
526218003583	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
526218003584	active site
526218003585	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
526218003586	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
526218003587	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
526218003588	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
526218003589	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
526218003590	active site
526218003591	GMP synthase; Reviewed; Region: guaA; PRK00074
526218003592	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
526218003593	AMP/PPi binding site [chemical binding]; other site
526218003594	candidate oxyanion hole; other site
526218003595	catalytic triad [active]
526218003596	potential glutamine specificity residues [chemical binding]; other site
526218003597	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
526218003598	ATP Binding subdomain [chemical binding]; other site
526218003599	Ligand Binding sites [chemical binding]; other site
526218003600	Dimerization subdomain; other site
526218003601	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
526218003602	IHF - DNA interface [nucleotide binding]; other site
526218003603	IHF dimer interface [polypeptide binding]; other site
526218003604	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
526218003605	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
526218003606	dimer interface [polypeptide binding]; other site
526218003607	active site
526218003608	metal binding site [ion binding]; metal-binding site
526218003609	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
526218003610	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
526218003611	DNA binding residues [nucleotide binding]
526218003612	putative dimer interface [polypeptide binding]; other site
526218003613	microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th,  Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212
526218003614	active site
526218003615	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142
526218003616	RNAase interaction site [polypeptide binding]; other site
526218003617	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
526218003618	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
526218003619	FtsX-like permease family; Region: FtsX; pfam02687
526218003620	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
526218003621	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
526218003622	Walker A/P-loop; other site
526218003623	ATP binding site [chemical binding]; other site
526218003624	Q-loop/lid; other site
526218003625	ABC transporter signature motif; other site
526218003626	Walker B; other site
526218003627	D-loop; other site
526218003628	H-loop/switch region; other site
526218003629	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
526218003630	30S subunit binding site; other site
526218003631	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
526218003632	MarR family; Region: MarR_2; cl17246
526218003633	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526218003634	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
526218003635	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
526218003636	phosphate binding site [ion binding]; other site
526218003637	putative substrate binding pocket [chemical binding]; other site
526218003638	dimer interface [polypeptide binding]; other site
526218003639	[FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918
526218003640	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
526218003641	G1 box; other site
526218003642	GTP/Mg2+ binding site [chemical binding]; other site
526218003643	Switch I region; other site
526218003644	G2 box; other site
526218003645	Switch II region; other site
526218003646	G3 box; other site
526218003647	G4 box; other site
526218003648	G5 box; other site
526218003649	rod shape-determining protein MreC; Provisional; Region: PRK13922
526218003650	rod shape-determining protein MreC; Region: MreC; pfam04085
526218003651	Recombination protein O N terminal; Region: RecO_N; pfam11967
526218003652	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218003653	active site
526218003654	phosphorylation site [posttranslational modification]
526218003655	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
526218003656	ATP cone domain; Region: ATP-cone; pfam03477
526218003657	Domain of unknown function (DUF368); Region: DUF368; pfam04018
526218003658	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
526218003659	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
526218003660	active site
526218003661	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
526218003662	protein binding site [polypeptide binding]; other site
526218003663	Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
526218003664	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
526218003665	putative active site [active]
526218003666	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
526218003667	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
526218003668	Ligand Binding Site [chemical binding]; other site
526218003669	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526218003670	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526218003671	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
526218003672	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
526218003673	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
526218003674	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
526218003675	HIRAN domain; Region: HIRAN; pfam08797
526218003676	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
526218003677	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
526218003678	catalytic triad [active]
526218003679	Predicted integral membrane protein [Function unknown]; Region: COG0392
526218003680	Uncharacterized conserved protein [Function unknown]; Region: COG2898
526218003681	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
526218003682	asparagine synthetase AsnA; Provisional; Region: PRK05425
526218003683	motif 1; other site
526218003684	dimer interface [polypeptide binding]; other site
526218003685	active site
526218003686	motif 2; other site
526218003687	motif 3; other site
526218003688	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218003689	Uncharacterized conserved protein [Function unknown]; Region: COG3937
526218003690	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
526218003691	Domain of unknown function (DUF4343); Region: DUF4343; pfam14243
526218003692	Uncharacterized protein conserved in bacteria (DUF2247); Region: DUF2247; cl01763
526218003693	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
526218003694	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
526218003695	Domain of unknown function (DUF4356); Region: DUF4356; pfam14266
526218003696	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
526218003697	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
526218003698	putative metal binding site [ion binding]; other site
526218003699	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
526218003700	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
526218003701	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
526218003702	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
526218003703	Soluble P-type ATPase [General function prediction only]; Region: COG4087
526218003704	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
526218003705	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526218003706	Coenzyme A binding pocket [chemical binding]; other site
526218003707	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
526218003708	GIY-YIG motif/motif A; other site
526218003709	putative active site [active]
526218003710	putative metal binding site [ion binding]; other site
526218003711	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
526218003712	active site
526218003713	putative DNA-binding cleft [nucleotide binding]; other site
526218003714	dimer interface [polypeptide binding]; other site
526218003715	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
526218003716	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
526218003717	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
526218003718	N-acetyl-D-glucosamine binding site [chemical binding]; other site
526218003719	catalytic residue [active]
526218003720	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613
526218003721	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526218003722	FeS/SAM binding site; other site
526218003723	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
526218003724	thymidylate synthase; Reviewed; Region: thyA; PRK01827
526218003725	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
526218003726	dimerization interface [polypeptide binding]; other site
526218003727	active site
526218003728	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
526218003729	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
526218003730	folate binding site [chemical binding]; other site
526218003731	NADP+ binding site [chemical binding]; other site
526218003732	WHG domain; Region: WHG; pfam13305
526218003733	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
526218003734	PRD domain; Region: PRD; pfam00874
526218003735	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
526218003736	active site
526218003737	P-loop; other site
526218003738	phosphorylation site [posttranslational modification]
526218003739	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218003740	active site
526218003741	phosphorylation site [posttranslational modification]
526218003742	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
526218003743	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
526218003744	NAD(P) binding site [chemical binding]; other site
526218003745	LDH/MDH dimer interface [polypeptide binding]; other site
526218003746	substrate binding site [chemical binding]; other site
526218003747	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
526218003748	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
526218003749	active site
526218003750	trimer interface [polypeptide binding]; other site
526218003751	allosteric site; other site
526218003752	active site lid [active]
526218003753	hexamer (dimer of trimers) interface [polypeptide binding]; other site
526218003754	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
526218003755	methionine cluster; other site
526218003756	active site
526218003757	phosphorylation site [posttranslational modification]
526218003758	metal binding site [ion binding]; metal-binding site
526218003759	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
526218003760	active site
526218003761	P-loop; other site
526218003762	phosphorylation site [posttranslational modification]
526218003763	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
526218003764	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
526218003765	Protein of unknown function (DUF3224); Region: DUF3224; pfam11528
526218003766	H+ Antiporter protein; Region: 2A0121; TIGR00900
526218003767	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526218003768	putative substrate translocation pore; other site
526218003769	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
526218003770	putative acyl-acceptor binding pocket; other site
526218003771	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
526218003772	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
526218003773	active site
526218003774	HIGH motif; other site
526218003775	KMSKS motif; other site
526218003776	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
526218003777	anticodon binding site; other site
526218003778	tRNA binding surface [nucleotide binding]; other site
526218003779	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
526218003780	dimer interface [polypeptide binding]; other site
526218003781	putative tRNA-binding site [nucleotide binding]; other site
526218003782	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
526218003783	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218003784	binding surface
526218003785	TPR motif; other site
526218003786	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
526218003787	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
526218003788	catalytic residues [active]
526218003789	Uncharacterized protein with conserved CXXC pairs [Function unknown]; Region: COG3862
526218003790	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
526218003791	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
526218003792	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
526218003793	Predicted dehydrogenase [General function prediction only]; Region: COG0579
526218003794	hydroxyglutarate oxidase; Provisional; Region: PRK11728
526218003795	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
526218003796	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
526218003797	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
526218003798	active site
526218003799	HIGH motif; other site
526218003800	nucleotide binding site [chemical binding]; other site
526218003801	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
526218003802	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
526218003803	active site
526218003804	KMSKS motif; other site
526218003805	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
526218003806	tRNA binding surface [nucleotide binding]; other site
526218003807	anticodon binding site; other site
526218003808	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
526218003809	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
526218003810	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
526218003811	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
526218003812	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
526218003813	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
526218003814	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
526218003815	CutC family; Region: CutC; cl01218
526218003816	Staphylococcal nuclease homologues; Region: SNc; smart00318
526218003817	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
526218003818	Catalytic site; other site
526218003819	Protein of unknown function (DUF3843); Region: DUF3843; pfam12954
526218003820	Sulfatase; Region: Sulfatase; cl17466
526218003821	Domain of unknown function (DUF4253); Region: DUF4253; pfam14062
526218003822	coproporphyrinogen III oxidase; Validated; Region: PRK08208
526218003823	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526218003824	FeS/SAM binding site; other site
526218003825	HemN C-terminal domain; Region: HemN_C; pfam06969
526218003826	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
526218003827	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
526218003828	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526218003829	motif II; other site
526218003830	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
526218003831	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
526218003832	active site
526218003833	P-loop; other site
526218003834	phosphorylation site [posttranslational modification]
526218003835	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218003836	active site
526218003837	phosphorylation site [posttranslational modification]
526218003838	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
526218003839	intersubunit interface [polypeptide binding]; other site
526218003840	active site
526218003841	zinc binding site [ion binding]; other site
526218003842	Na+ binding site [ion binding]; other site
526218003843	Domain of unknown function (DUF4280); Region: DUF4280; pfam14107
526218003844	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
526218003845	active site
526218003846	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
526218003847	selenophosphate synthetase; Provisional; Region: PRK00943
526218003848	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
526218003849	dimerization interface [polypeptide binding]; other site
526218003850	putative ATP binding site [chemical binding]; other site
526218003851	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
526218003852	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
526218003853	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
526218003854	catalytic residue [active]
526218003855	peptidase; Reviewed; Region: PRK13004
526218003856	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649
526218003857	putative metal binding site [ion binding]; other site
526218003858	putative dimer interface [polypeptide binding]; other site
526218003859	aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200
526218003860	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
526218003861	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
526218003862	carbamate kinase; Reviewed; Region: PRK12686
526218003863	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
526218003864	putative substrate binding site [chemical binding]; other site
526218003865	nucleotide binding site [chemical binding]; other site
526218003866	nucleotide binding site [chemical binding]; other site
526218003867	homodimer interface [polypeptide binding]; other site
526218003868	xanthine permease; Region: pbuX; TIGR03173
526218003869	xanthine permease; Region: pbuX; TIGR03173
526218003870	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
526218003871	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
526218003872	active site
526218003873	putative substrate binding pocket [chemical binding]; other site
526218003874	xanthine permease; Region: pbuX; TIGR03173
526218003875	putative selenate reductase subunit YgfK; Provisional; Region: PRK09853
526218003876	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
526218003877	putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203
526218003878	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
526218003879	active site
526218003880	putative substrate binding pocket [chemical binding]; other site
526218003881	selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311
526218003882	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
526218003883	catalytic loop [active]
526218003884	iron binding site [ion binding]; other site
526218003885	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
526218003886	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
526218003887	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
526218003888	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
526218003889	homotrimer interaction site [polypeptide binding]; other site
526218003890	putative active site [active]
526218003891	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
526218003892	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
526218003893	dimer interface [polypeptide binding]; other site
526218003894	putative functional site; other site
526218003895	putative MPT binding site; other site
526218003896	putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498
526218003897	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
526218003898	dimer interface [polypeptide binding]; other site
526218003899	putative functional site; other site
526218003900	putative MPT binding site; other site
526218003901	PBP superfamily domain; Region: PBP_like; pfam12727
526218003902	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
526218003903	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
526218003904	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
526218003905	ThiS family; Region: ThiS; pfam02597
526218003906	charged pocket; other site
526218003907	hydrophobic patch; other site
526218003908	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
526218003909	thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356
526218003910	ATP binding site [chemical binding]; other site
526218003911	substrate interface [chemical binding]; other site
526218003912	PBP superfamily domain; Region: PBP_like_2; pfam12849
526218003913	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
526218003914	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526218003915	dimer interface [polypeptide binding]; other site
526218003916	conserved gate region; other site
526218003917	putative PBP binding loops; other site
526218003918	ABC-ATPase subunit interface; other site
526218003919	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
526218003920	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
526218003921	Walker A/P-loop; other site
526218003922	ATP binding site [chemical binding]; other site
526218003923	Q-loop/lid; other site
526218003924	ABC transporter signature motif; other site
526218003925	Walker B; other site
526218003926	D-loop; other site
526218003927	H-loop/switch region; other site
526218003928	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
526218003929	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526218003930	FeS/SAM binding site; other site
526218003931	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
526218003932	phenylhydantoinase; Validated; Region: PRK08323
526218003933	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
526218003934	tetramer interface [polypeptide binding]; other site
526218003935	active site
526218003936	probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172
526218003937	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
526218003938	Ligand binding site; other site
526218003939	metal-binding site
526218003940	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
526218003941	MPT binding site; other site
526218003942	trimer interface [polypeptide binding]; other site
526218003943	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
526218003944	putative MPT binding site; other site
526218003945	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
526218003946	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
526218003947	metal binding site [ion binding]; metal-binding site
526218003948	dimer interface [polypeptide binding]; other site
526218003949	MOSC domain; Region: MOSC; pfam03473
526218003950	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
526218003951	trimer interface [polypeptide binding]; other site
526218003952	dimer interface [polypeptide binding]; other site
526218003953	putative active site [active]
526218003954	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
526218003955	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
526218003956	benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263
526218003957	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
526218003958	selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309
526218003959	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
526218003960	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
526218003961	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
526218003962	XdhC Rossmann domain; Region: XdhC_C; pfam13478
526218003963	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
526218003964	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
526218003965	Ligand Binding Site [chemical binding]; other site
526218003966	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
526218003967	methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395
526218003968	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
526218003969	ligand binding site [chemical binding]; other site
526218003970	calcium binding site [ion binding]; other site
526218003971	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
526218003972	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
526218003973	Walker A/P-loop; other site
526218003974	ATP binding site [chemical binding]; other site
526218003975	Q-loop/lid; other site
526218003976	ABC transporter signature motif; other site
526218003977	Walker B; other site
526218003978	D-loop; other site
526218003979	H-loop/switch region; other site
526218003980	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
526218003981	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
526218003982	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
526218003983	TM-ABC transporter signature motif; other site
526218003984	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
526218003985	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526218003986	S-adenosylmethionine binding site [chemical binding]; other site
526218003987	RibD C-terminal domain; Region: RibD_C; cl17279
526218003988	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
526218003989	histidinol-phosphatase; Provisional; Region: PRK07328
526218003990	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
526218003991	active site
526218003992	dimer interface [polypeptide binding]; other site
526218003993	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526218003994	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526218003995	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
526218003996	FMN binding site [chemical binding]; other site
526218003997	active site
526218003998	catalytic residues [active]
526218003999	substrate binding site [chemical binding]; other site
526218004000	Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777
526218004001	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
526218004002	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
526218004003	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
526218004004	6-phosphofructokinase; Provisional; Region: PRK03202
526218004005	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
526218004006	active site
526218004007	ADP/pyrophosphate binding site [chemical binding]; other site
526218004008	dimerization interface [polypeptide binding]; other site
526218004009	allosteric effector site; other site
526218004010	fructose-1,6-bisphosphate binding site; other site
526218004011	pyruvate kinase; Provisional; Region: PRK09206
526218004012	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
526218004013	domain interfaces; other site
526218004014	active site
526218004015	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413
526218004016	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
526218004017	active site
526218004018	recombination protein RecR; Reviewed; Region: recR; PRK00076
526218004019	RecR protein; Region: RecR; pfam02132
526218004020	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
526218004021	putative active site [active]
526218004022	putative metal-binding site [ion binding]; other site
526218004023	tetramer interface [polypeptide binding]; other site
526218004024	Autotransporter beta-domain; Region: Autotransporter; smart00869
526218004025	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
526218004026	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
526218004027	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
526218004028	active site turn [active]
526218004029	phosphorylation site [posttranslational modification]
526218004030	Protein of unknown function (DUF3604); Region: DUF3604; pfam12228
526218004031	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
526218004032	Sulfatase; Region: Sulfatase; cl17466
526218004033	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
526218004034	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
526218004035	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
526218004036	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
526218004037	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
526218004038	S-adenosylmethionine synthetase; Validated; Region: PRK05250
526218004039	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
526218004040	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
526218004041	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
526218004042	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
526218004043	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526218004044	motif II; other site
526218004045	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526218004046	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218004047	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
526218004048	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
526218004049	PRD domain; Region: PRD; pfam00874
526218004050	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
526218004051	active site
526218004052	P-loop; other site
526218004053	phosphorylation site [posttranslational modification]
526218004054	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218004055	active site
526218004056	phosphorylation site [posttranslational modification]
526218004057	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218004058	active site
526218004059	phosphorylation site [posttranslational modification]
526218004060	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
526218004061	active site
526218004062	P-loop; other site
526218004063	phosphorylation site [posttranslational modification]
526218004064	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
526218004065	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
526218004066	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
526218004067	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
526218004068	putative substrate binding site [chemical binding]; other site
526218004069	putative ATP binding site [chemical binding]; other site
526218004070	hypothetical protein; Provisional; Region: PRK06357
526218004071	intersubunit interface [polypeptide binding]; other site
526218004072	active site
526218004073	Zn2+ binding site [ion binding]; other site
526218004074	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
526218004075	dimerization domain swap beta strand [polypeptide binding]; other site
526218004076	regulatory protein interface [polypeptide binding]; other site
526218004077	active site
526218004078	regulatory phosphorylation site [posttranslational modification]; other site
526218004079	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218004080	Predicted acetyltransferase [General function prediction only]; Region: COG2388
526218004081	myosin-cross-reactive antigen; Provisional; Region: PRK13977
526218004082	deoxyguanosinetriphosphate triphosphohydrolase, putative; Region: dGTP_triPase; TIGR01353
526218004083	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
526218004084	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
526218004085	GTPase Era; Reviewed; Region: era; PRK00089
526218004086	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
526218004087	G1 box; other site
526218004088	GTP/Mg2+ binding site [chemical binding]; other site
526218004089	Switch I region; other site
526218004090	G2 box; other site
526218004091	Switch II region; other site
526218004092	G3 box; other site
526218004093	G4 box; other site
526218004094	G5 box; other site
526218004095	KH domain; Region: KH_2; pfam07650
526218004096	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
526218004097	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
526218004098	active site
526218004099	metal binding site [ion binding]; metal-binding site
526218004100	Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403
526218004101	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
526218004102	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526218004103	active site
526218004104	motif I; other site
526218004105	motif II; other site
526218004106	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
526218004107	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
526218004108	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
526218004109	active site
526218004110	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
526218004111	generic binding surface II; other site
526218004112	generic binding surface I; other site
526218004113	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
526218004114	carboxyltransferase (CT) interaction site; other site
526218004115	biotinylation site [posttranslational modification]; other site
526218004116	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
526218004117	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
526218004118	ATP-grasp domain; Region: ATP-grasp_4; cl17255
526218004119	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
526218004120	Asp23 family; Region: Asp23; pfam03780
526218004121	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
526218004122	putative RNA binding site [nucleotide binding]; other site
526218004123	Response regulator receiver domain; Region: Response_reg; pfam00072
526218004124	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526218004125	active site
526218004126	phosphorylation site [posttranslational modification]
526218004127	intermolecular recognition site; other site
526218004128	dimerization interface [polypeptide binding]; other site
526218004129	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
526218004130	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
526218004131	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
526218004132	metal-binding site [ion binding]
526218004133	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
526218004134	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
526218004135	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
526218004136	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526218004137	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
526218004138	EamA-like transporter family; Region: EamA; pfam00892
526218004139	EamA-like transporter family; Region: EamA; pfam00892
526218004140	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
526218004141	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
526218004142	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526218004143	Coenzyme A binding pocket [chemical binding]; other site
526218004144	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
526218004145	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
526218004146	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
526218004147	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
526218004148	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
526218004149	DKNYY family; Region: DKNYY; pfam13644
526218004150	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
526218004151	active site
526218004152	metal binding site [ion binding]; metal-binding site
526218004153	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
526218004154	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526218004155	Coenzyme A binding pocket [chemical binding]; other site
526218004156	N-glycosylase/DNA lyase; Provisional; Region: PRK01229
526218004157	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
526218004158	minor groove reading motif; other site
526218004159	helix-hairpin-helix signature motif; other site
526218004160	active site
526218004161	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
526218004162	catalytic residues [active]
526218004163	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
526218004164	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
526218004165	ligand binding site [chemical binding]; other site
526218004166	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
526218004167	Putative esterase; Region: Esterase; pfam00756
526218004168	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
526218004169	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
526218004170	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
526218004171	ligand binding site [chemical binding]; other site
526218004172	hypothetical protein; Provisional; Region: PRK10977
526218004173	Pyruvate formate lyase; Region: PFL; pfam02901
526218004174	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
526218004175	glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041
526218004176	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526218004177	FeS/SAM binding site; other site
526218004178	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218004179	Protein of unknown function (DUF4240); Region: DUF4240; pfam14024
526218004180	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
526218004181	ligand binding site [chemical binding]; other site
526218004182	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
526218004183	purine nucleoside phosphorylase; Provisional; Region: PRK08202
526218004184	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
526218004185	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
526218004186	ligand binding site [chemical binding]; other site
526218004187	flexible hinge region; other site
526218004188	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
526218004189	non-specific DNA interactions [nucleotide binding]; other site
526218004190	DNA binding site [nucleotide binding]
526218004191	sequence specific DNA binding site [nucleotide binding]; other site
526218004192	putative cAMP binding site [chemical binding]; other site
526218004193	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
526218004194	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
526218004195	ligand binding site [chemical binding]; other site
526218004196	flexible hinge region; other site
526218004197	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
526218004198	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
526218004199	Walker A/P-loop; other site
526218004200	ATP binding site [chemical binding]; other site
526218004201	Q-loop/lid; other site
526218004202	ABC transporter signature motif; other site
526218004203	Walker B; other site
526218004204	D-loop; other site
526218004205	H-loop/switch region; other site
526218004206	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
526218004207	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
526218004208	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
526218004209	TM-ABC transporter signature motif; other site
526218004210	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
526218004211	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
526218004212	TM-ABC transporter signature motif; other site
526218004213	Thymidine phosphorylase [Nucleotide transport and metabolism]; Region: DeoA; COG0213
526218004214	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
526218004215	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
526218004216	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
526218004217	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
526218004218	intersubunit interface [polypeptide binding]; other site
526218004219	active site
526218004220	catalytic residue [active]
526218004221	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
526218004222	phosphopentomutase; Provisional; Region: PRK05362
526218004223	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
526218004224	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
526218004225	active site
526218004226	metal binding site [ion binding]; metal-binding site
526218004227	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
526218004228	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
526218004229	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
526218004230	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
526218004231	active site
526218004232	catalytic motif [active]
526218004233	Zn binding site [ion binding]; other site
526218004234	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
526218004235	Na binding site [ion binding]; other site
526218004236	Predicted membrane protein [Function unknown]; Region: COG4905
526218004237	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
526218004238	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
526218004239	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
526218004240	DNA binding residues [nucleotide binding]
526218004241	putative dimer interface [polypeptide binding]; other site
526218004242	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
526218004243	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
526218004244	Niemann-Pick C type protein family; Region: 2A060601; TIGR00917
526218004245	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
526218004246	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
526218004247	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
526218004248	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
526218004249	active site
526218004250	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
526218004251	dimer interface [polypeptide binding]; other site
526218004252	substrate binding site [chemical binding]; other site
526218004253	catalytic residues [active]
526218004254	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
526218004255	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
526218004256	Substrate binding site; other site
526218004257	Cupin domain; Region: Cupin_2; cl17218
526218004258	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
526218004259	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
526218004260	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
526218004261	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
526218004262	active site
526218004263	metal binding site [ion binding]; metal-binding site
526218004264	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526218004265	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
526218004266	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
526218004267	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
526218004268	catalytic residues [active]
526218004269	Domain of unknown function (DUF305); Region: DUF305; pfam03713
526218004270	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
526218004271	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
526218004272	putative active site [active]
526218004273	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
526218004274	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
526218004275	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
526218004276	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
526218004277	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
526218004278	active site
526218004279	DKNYY family; Region: DKNYY; pfam13644
526218004280	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
526218004281	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
526218004282	peptide binding site [polypeptide binding]; other site
526218004283	DKNYY family; Region: DKNYY; pfam13644
526218004284	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
526218004285	DNA topoisomerase I; Validated; Region: PRK06599
526218004286	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
526218004287	active site
526218004288	interdomain interaction site; other site
526218004289	putative metal-binding site [ion binding]; other site
526218004290	nucleotide binding site [chemical binding]; other site
526218004291	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
526218004292	domain I; other site
526218004293	DNA binding groove [nucleotide binding]
526218004294	phosphate binding site [ion binding]; other site
526218004295	domain II; other site
526218004296	domain III; other site
526218004297	nucleotide binding site [chemical binding]; other site
526218004298	catalytic site [active]
526218004299	domain IV; other site
526218004300	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
526218004301	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
526218004302	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
526218004303	active site
526218004304	DNA binding site [nucleotide binding]
526218004305	Int/Topo IB signature motif; other site
526218004306	ribosome biogenesis GTPase YqeH; Region: GTPase_YqeH; TIGR03597
526218004307	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
526218004308	GTP/Mg2+ binding site [chemical binding]; other site
526218004309	G4 box; other site
526218004310	G5 box; other site
526218004311	G1 box; other site
526218004312	Switch I region; other site
526218004313	G2 box; other site
526218004314	Peptidase family M48; Region: Peptidase_M48; cl12018
526218004315	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
526218004316	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
526218004317	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
526218004318	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526218004319	dimerization interface [polypeptide binding]; other site
526218004320	putative DNA binding site [nucleotide binding]; other site
526218004321	putative Zn2+ binding site [ion binding]; other site
526218004322	Protein of unknown function (DUF2695); Region: DUF2695; pfam10905
526218004323	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
526218004324	dimer interface [polypeptide binding]; other site
526218004325	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526218004326	ligand binding site [chemical binding]; other site
526218004327	Autotransporter beta-domain; Region: Autotransporter; smart00869
526218004328	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
526218004329	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
526218004330	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
526218004331	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
526218004332	Protein of unknown function (DUF503); Region: DUF503; cl00669
526218004333	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
526218004334	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
526218004335	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140
526218004336	conserved cys residue [active]
526218004337	Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674
526218004338	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
526218004339	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
526218004340	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
526218004341	active site
526218004342	P-loop; other site
526218004343	phosphorylation site [posttranslational modification]
526218004344	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
526218004345	HTH domain; Region: HTH_11; pfam08279
526218004346	PRD domain; Region: PRD; pfam00874
526218004347	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
526218004348	active site
526218004349	P-loop; other site
526218004350	phosphorylation site [posttranslational modification]
526218004351	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218004352	active site
526218004353	phosphorylation site [posttranslational modification]
526218004354	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
526218004355	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
526218004356	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
526218004357	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
526218004358	active site
526218004359	dimer interface [polypeptide binding]; other site
526218004360	magnesium binding site [ion binding]; other site
526218004361	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
526218004362	tetramer interface [polypeptide binding]; other site
526218004363	active site
526218004364	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
526218004365	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
526218004366	dimer interface [polypeptide binding]; other site
526218004367	active site
526218004368	metal binding site [ion binding]; metal-binding site
526218004369	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
526218004370	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526218004371	Walker A/P-loop; other site
526218004372	ATP binding site [chemical binding]; other site
526218004373	Q-loop/lid; other site
526218004374	ABC transporter signature motif; other site
526218004375	Walker B; other site
526218004376	D-loop; other site
526218004377	H-loop/switch region; other site
526218004378	ABC transporter; Region: ABC_tran_2; pfam12848
526218004379	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
526218004380	Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Region: HIS2; COG1387
526218004381	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
526218004382	active site
526218004383	dimer interface [polypeptide binding]; other site
526218004384	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
526218004385	dimer interface [polypeptide binding]; other site
526218004386	ADP-ribose binding site [chemical binding]; other site
526218004387	active site
526218004388	nudix motif; other site
526218004389	metal binding site [ion binding]; metal-binding site
526218004390	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
526218004391	MgtE intracellular N domain; Region: MgtE_N; smart00924
526218004392	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
526218004393	Divalent cation transporter; Region: MgtE; pfam01769
526218004394	Protein of unknown function DUF45; Region: DUF45; pfam01863
526218004395	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
526218004396	active site
526218004397	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
526218004398	DNA binding residues [nucleotide binding]
526218004399	signal recognition particle protein; Provisional; Region: PRK10867
526218004400	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
526218004401	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
526218004402	P loop; other site
526218004403	GTP binding site [chemical binding]; other site
526218004404	Signal peptide binding domain; Region: SRP_SPB; pfam02978
526218004405	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
526218004406	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
526218004407	Methyltransferase domain; Region: Methyltransf_31; pfam13847
526218004408	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526218004409	S-adenosylmethionine binding site [chemical binding]; other site
526218004410	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
526218004411	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
526218004412	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
526218004413	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
526218004414	substrate binding pocket [chemical binding]; other site
526218004415	membrane-bound complex binding site; other site
526218004416	hinge residues; other site
526218004417	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
526218004418	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526218004419	dimer interface [polypeptide binding]; other site
526218004420	conserved gate region; other site
526218004421	putative PBP binding loops; other site
526218004422	ABC-ATPase subunit interface; other site
526218004423	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
526218004424	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
526218004425	Walker A/P-loop; other site
526218004426	ATP binding site [chemical binding]; other site
526218004427	Q-loop/lid; other site
526218004428	ABC transporter signature motif; other site
526218004429	Walker B; other site
526218004430	D-loop; other site
526218004431	H-loop/switch region; other site
526218004432	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
526218004433	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
526218004434	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
526218004435	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
526218004436	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
526218004437	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
526218004438	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
526218004439	nudix motif; other site
526218004440	Uncharacterized conserved protein (DUF2278); Region: DUF2278; cl17857
526218004441	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
526218004442	GTP cyclohydrolase I; Provisional; Region: PLN03044
526218004443	active site
526218004444	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
526218004445	homooctamer interface [polypeptide binding]; other site
526218004446	active site
526218004447	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
526218004448	catalytic center binding site [active]
526218004449	ATP binding site [chemical binding]; other site
526218004450	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
526218004451	dihydropteroate synthase; Region: DHPS; TIGR01496
526218004452	substrate binding pocket [chemical binding]; other site
526218004453	dimer interface [polypeptide binding]; other site
526218004454	inhibitor binding site; inhibition site
526218004455	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
526218004456	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
526218004457	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
526218004458	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
526218004459	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
526218004460	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526218004461	Walker A/P-loop; other site
526218004462	ATP binding site [chemical binding]; other site
526218004463	Q-loop/lid; other site
526218004464	ABC transporter signature motif; other site
526218004465	Walker B; other site
526218004466	D-loop; other site
526218004467	H-loop/switch region; other site
526218004468	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
526218004469	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
526218004470	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
526218004471	Walker A/P-loop; other site
526218004472	ATP binding site [chemical binding]; other site
526218004473	Q-loop/lid; other site
526218004474	ABC transporter signature motif; other site
526218004475	Walker B; other site
526218004476	D-loop; other site
526218004477	H-loop/switch region; other site
526218004478	Helix-turn-helix domain; Region: HTH_18; pfam12833
526218004479	intimin-like protein SinH; Provisional; Region: PRK15318
526218004480	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
526218004481	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
526218004482	active site
526218004483	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
526218004484	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
526218004485	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526218004486	active site
526218004487	phosphorylation site [posttranslational modification]
526218004488	intermolecular recognition site; other site
526218004489	dimerization interface [polypeptide binding]; other site
526218004490	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
526218004491	DNA binding site [nucleotide binding]
526218004492	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
526218004493	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
526218004494	dimerization interface [polypeptide binding]; other site
526218004495	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
526218004496	dimer interface [polypeptide binding]; other site
526218004497	phosphorylation site [posttranslational modification]
526218004498	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526218004499	ATP binding site [chemical binding]; other site
526218004500	Mg2+ binding site [ion binding]; other site
526218004501	G-X-G motif; other site
526218004502	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
526218004503	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
526218004504	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
526218004505	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526218004506	FeS/SAM binding site; other site
526218004507	Uncharacterized conserved protein [Function unknown]; Region: COG3189
526218004508	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
526218004509	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
526218004510	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
526218004511	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
526218004512	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
526218004513	heterotetramer interface [polypeptide binding]; other site
526218004514	active site pocket [active]
526218004515	cleavage site
526218004516	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
526218004517	feedback inhibition sensing region; other site
526218004518	homohexameric interface [polypeptide binding]; other site
526218004519	nucleotide binding site [chemical binding]; other site
526218004520	N-acetyl-L-glutamate binding site [chemical binding]; other site
526218004521	acetylornithine aminotransferase; Provisional; Region: PRK02627
526218004522	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
526218004523	inhibitor-cofactor binding pocket; inhibition site
526218004524	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526218004525	catalytic residue [active]
526218004526	ornithine carbamoyltransferase; Validated; Region: PRK02102
526218004527	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
526218004528	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
526218004529	DKNYY family; Region: DKNYY; pfam13644
526218004530	DKNYY family; Region: DKNYY; pfam13644
526218004531	DKNYY family; Region: DKNYY; pfam13644
526218004532	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
526218004533	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
526218004534	substrate binding site [chemical binding]; other site
526218004535	ATP binding site [chemical binding]; other site
526218004536	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
526218004537	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
526218004538	SLBB domain; Region: SLBB; pfam10531
526218004539	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
526218004540	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
526218004541	PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526
526218004542	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
526218004543	putative hexamer interface [polypeptide binding]; other site
526218004544	putative hexagonal pore; other site
526218004545	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
526218004546	putative hexamer interface [polypeptide binding]; other site
526218004547	putative hexagonal pore; other site
526218004548	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526218004549	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526218004550	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
526218004551	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
526218004552	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
526218004553	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
526218004554	Soluble P-type ATPase [General function prediction only]; Region: COG4087
526218004555	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
526218004556	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
526218004557	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
526218004558	16S/18S rRNA binding site [nucleotide binding]; other site
526218004559	S13e-L30e interaction site [polypeptide binding]; other site
526218004560	25S rRNA binding site [nucleotide binding]; other site
526218004561	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
526218004562	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
526218004563	Coenzyme A binding pocket [chemical binding]; other site
526218004564	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
526218004565	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_1; cd13140
526218004566	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
526218004567	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526218004568	Coenzyme A binding pocket [chemical binding]; other site
526218004569	Predicted membrane protein [Function unknown]; Region: COG4818
526218004570	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
526218004571	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
526218004572	spore photoproduct lyase; Region: photo_TT_lyase; cl15393
526218004573	DNA polymerase III, delta subunit; Region: holA; TIGR01128
526218004574	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
526218004575	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218004576	active site
526218004577	phosphorylation site [posttranslational modification]
526218004578	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
526218004579	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
526218004580	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
526218004581	active site
526218004582	P-loop; other site
526218004583	phosphorylation site [posttranslational modification]
526218004584	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
526218004585	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
526218004586	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
526218004587	putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983
526218004588	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
526218004589	dimer interface [polypeptide binding]; other site
526218004590	active site
526218004591	glycine loop; other site
526218004592	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
526218004593	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526218004594	FeS/SAM binding site; other site
526218004595	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
526218004596	active site
526218004597	intersubunit interactions; other site
526218004598	catalytic residue [active]
526218004599	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218004600	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
526218004601	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
526218004602	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
526218004603	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
526218004604	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
526218004605	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
526218004606	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
526218004607	Zn2+ binding site [ion binding]; other site
526218004608	Mg2+ binding site [ion binding]; other site
526218004609	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
526218004610	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
526218004611	PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383
526218004612	active site
526218004613	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
526218004614	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
526218004615	DHHA2 domain; Region: DHHA2; pfam02833
526218004616	Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classI; cd00643
526218004617	tetramerization interface [polypeptide binding]; other site
526218004618	substrate binding pocket [chemical binding]; other site
526218004619	catalytic residues [active]
526218004620	inhibitor binding sites; inhibition site
526218004621	NADP(H) binding site [chemical binding]; other site
526218004622	prenyltransferase; Provisional; Region: ubiA; PRK13592
526218004623	phosphoenolpyruvate synthase; Validated; Region: PRK06241
526218004624	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
526218004625	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
526218004626	Protein of unknown function (DUF3419); Region: DUF3419; cl15422
526218004627	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
526218004628	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526218004629	Coenzyme A binding pocket [chemical binding]; other site
526218004630	peptide synthase; Provisional; Region: PRK09274
526218004631	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526218004632	acyl-activating enzyme (AAE) consensus motif; other site
526218004633	AMP binding site [chemical binding]; other site
526218004634	active site
526218004635	CoA binding site [chemical binding]; other site
526218004636	fumarate hydratase; Provisional; Region: PRK06246
526218004637	Fumarase C-terminus; Region: Fumerase_C; cl00795
526218004638	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
526218004639	Malic enzyme, N-terminal domain; Region: malic; pfam00390
526218004640	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
526218004641	putative NAD(P) binding site [chemical binding]; other site
526218004642	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884
526218004643	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
526218004644	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
526218004645	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
526218004646	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
526218004647	maltose O-acetyltransferase; Provisional; Region: PRK10092
526218004648	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
526218004649	active site
526218004650	substrate binding site [chemical binding]; other site
526218004651	trimer interface [polypeptide binding]; other site
526218004652	CoA binding site [chemical binding]; other site
526218004653	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
526218004654	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
526218004655	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
526218004656	putative active site [active]
526218004657	Pirin-related protein [General function prediction only]; Region: COG1741
526218004658	Pirin; Region: Pirin; pfam02678
526218004659	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
526218004660	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
526218004661	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
526218004662	putative substrate binding site [chemical binding]; other site
526218004663	putative ATP binding site [chemical binding]; other site
526218004664	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
526218004665	active site
526218004666	P-loop; other site
526218004667	phosphorylation site [posttranslational modification]
526218004668	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
526218004669	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
526218004670	intersubunit interface [polypeptide binding]; other site
526218004671	active site
526218004672	zinc binding site [ion binding]; other site
526218004673	Na+ binding site [ion binding]; other site
526218004674	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218004675	active site
526218004676	phosphorylation site [posttranslational modification]
526218004677	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
526218004678	histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856
526218004679	active site
526218004680	Membrane protein required for beta-lactamase induction [Defense mechanisms]; Region: AmpE; cl17896
526218004681	maltose O-acetyltransferase; Provisional; Region: PRK10092
526218004682	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
526218004683	active site
526218004684	substrate binding site [chemical binding]; other site
526218004685	trimer interface [polypeptide binding]; other site
526218004686	CoA binding site [chemical binding]; other site
526218004687	Transcriptional regulator [Transcription]; Region: LysR; COG0583
526218004688	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
526218004689	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
526218004690	dimerization interface [polypeptide binding]; other site
526218004691	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
526218004692	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526218004693	Walker A/P-loop; other site
526218004694	ATP binding site [chemical binding]; other site
526218004695	Q-loop/lid; other site
526218004696	ABC transporter signature motif; other site
526218004697	Walker B; other site
526218004698	H-loop/switch region; other site
526218004699	Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase [Posttranslational modification, protein turnover, chaperones / Transcription]; Region: HypB; COG0378
526218004700	Domain of unknown function (DUF1858); Region: DUF1858; cl14817
526218004701	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
526218004702	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
526218004703	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
526218004704	RNase E interface [polypeptide binding]; other site
526218004705	trimer interface [polypeptide binding]; other site
526218004706	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
526218004707	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
526218004708	RNase E interface [polypeptide binding]; other site
526218004709	trimer interface [polypeptide binding]; other site
526218004710	active site
526218004711	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
526218004712	putative nucleic acid binding region [nucleotide binding]; other site
526218004713	G-X-X-G motif; other site
526218004714	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
526218004715	RNA binding site [nucleotide binding]; other site
526218004716	domain interface; other site
526218004717	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
526218004718	Predicted transcriptional regulators [Transcription]; Region: COG1378
526218004719	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
526218004720	Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124
526218004721	C-terminal domain interface [polypeptide binding]; other site
526218004722	sugar binding site [chemical binding]; other site
526218004723	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
526218004724	homodimer interface [polypeptide binding]; other site
526218004725	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
526218004726	active site pocket [active]
526218004727	cell division protein MraZ; Reviewed; Region: PRK00326
526218004728	MraZ protein; Region: MraZ; pfam02381
526218004729	MraZ protein; Region: MraZ; pfam02381
526218004730	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
526218004731	MraW methylase family; Region: Methyltransf_5; cl17771
526218004732	Putative esterase; Region: Esterase; pfam00756
526218004733	S-formylglutathione hydrolase; Region: PLN02442
526218004734	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
526218004735	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
526218004736	metal binding site [ion binding]; metal-binding site
526218004737	dimer interface [polypeptide binding]; other site
526218004738	TRAM domain; Region: TRAM; cl01282
526218004739	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
526218004740	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526218004741	S-adenosylmethionine binding site [chemical binding]; other site
526218004742	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
526218004743	Helix-turn-helix domain; Region: HTH_38; pfam13936
526218004744	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
526218004745	sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171
526218004746	classical (c) SDRs; Region: SDR_c; cd05233
526218004747	NAD(P) binding site [chemical binding]; other site
526218004748	active site
526218004749	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
526218004750	active pocket/dimerization site; other site
526218004751	active site
526218004752	phosphorylation site [posttranslational modification]
526218004753	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
526218004754	active site
526218004755	phosphorylation site [posttranslational modification]
526218004756	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
526218004757	PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828
526218004758	L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238
526218004759	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
526218004760	putative NAD(P) binding site [chemical binding]; other site
526218004761	catalytic Zn binding site [ion binding]; other site
526218004762	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
526218004763	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
526218004764	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
526218004765	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
526218004766	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
526218004767	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
526218004768	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
526218004769	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526218004770	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
526218004771	DNA binding residues [nucleotide binding]
526218004772	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
526218004773	DNA polymerase III subunit beta; Validated; Region: PRK05643
526218004774	putative DNA binding surface [nucleotide binding]; other site
526218004775	dimer interface [polypeptide binding]; other site
526218004776	beta-clamp/clamp loader binding surface; other site
526218004777	beta-clamp/translesion DNA polymerase binding surface; other site
526218004778	Domain of unknown function (DUF4259); Region: DUF4259; pfam14078
526218004779	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14953
526218004780	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526218004781	Walker A motif; other site
526218004782	ATP binding site [chemical binding]; other site
526218004783	Walker B motif; other site
526218004784	arginine finger; other site
526218004785	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
526218004786	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
526218004787	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
526218004788	replicative DNA helicase; Region: DnaB; TIGR00665
526218004789	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
526218004790	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
526218004791	Walker A motif; other site
526218004792	ATP binding site [chemical binding]; other site
526218004793	Walker B motif; other site
526218004794	DNA binding loops [nucleotide binding]
526218004795	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
526218004796	Peptidase family U32; Region: Peptidase_U32; pfam01136
526218004797	Protein of unknown function, DUF479; Region: DUF479; cl01203
526218004798	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
526218004799	Transglycosylase; Region: Transgly; pfam00912
526218004800	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
526218004801	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
526218004802	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
526218004803	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526218004804	FeS/SAM binding site; other site
526218004805	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
526218004806	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
526218004807	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
526218004808	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
526218004809	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526218004810	DNA-binding site [nucleotide binding]; DNA binding site
526218004811	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
526218004812	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
526218004813	ligand binding site [chemical binding]; other site
526218004814	active site
526218004815	UGI interface [polypeptide binding]; other site
526218004816	catalytic site [active]
526218004817	DNA polymerase I; Provisional; Region: PRK05755
526218004818	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
526218004819	active site
526218004820	metal binding site 1 [ion binding]; metal-binding site
526218004821	putative 5' ssDNA interaction site; other site
526218004822	metal binding site 3; metal-binding site
526218004823	metal binding site 2 [ion binding]; metal-binding site
526218004824	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
526218004825	putative DNA binding site [nucleotide binding]; other site
526218004826	putative metal binding site [ion binding]; other site
526218004827	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
526218004828	active site
526218004829	substrate binding site [chemical binding]; other site
526218004830	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
526218004831	active site
526218004832	DNA binding site [nucleotide binding]
526218004833	catalytic site [active]
526218004834	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526218004835	Coenzyme A binding pocket [chemical binding]; other site
526218004836	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
526218004837	Membrane transport protein; Region: Mem_trans; cl09117
526218004838	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
526218004839	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
526218004840	K+ potassium transporter; Region: K_trans; pfam02705
526218004841	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
526218004842	Uncharacterized conserved protein [Function unknown]; Region: COG1434
526218004843	putative active site [active]
526218004844	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
526218004845	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
526218004846	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
526218004847	tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682
526218004848	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
526218004849	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
526218004850	active site
526218004851	(T/H)XGH motif; other site
526218004852	seryl-tRNA synthetase; Provisional; Region: PRK05431
526218004853	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
526218004854	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
526218004855	dimer interface [polypeptide binding]; other site
526218004856	active site
526218004857	motif 1; other site
526218004858	motif 2; other site
526218004859	motif 3; other site
526218004860	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
526218004861	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
526218004862	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
526218004863	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
526218004864	intersubunit interface [polypeptide binding]; other site
526218004865	active site
526218004866	zinc binding site [ion binding]; other site
526218004867	Na+ binding site [ion binding]; other site
526218004868	Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162
526218004869	CTP synthetase; Validated; Region: pyrG; PRK05380
526218004870	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
526218004871	Catalytic site [active]
526218004872	active site
526218004873	UTP binding site [chemical binding]; other site
526218004874	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
526218004875	active site
526218004876	putative oxyanion hole; other site
526218004877	catalytic triad [active]
526218004878	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
526218004879	dimerization domain swap beta strand [polypeptide binding]; other site
526218004880	regulatory protein interface [polypeptide binding]; other site
526218004881	active site
526218004882	regulatory phosphorylation site [posttranslational modification]; other site
526218004883	M20 Peptidase Aminoacylase 1-like protein 2, amidohydrolase family; Region: M20_Acy1L2_like_2; cd09849
526218004884	Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546
526218004885	metal binding site [ion binding]; metal-binding site
526218004886	Protein of unknown function (DUF3100); Region: DUF3100; pfam11299
526218004887	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
526218004888	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
526218004889	Domain of unknown function (DUF814); Region: DUF814; pfam05670
526218004890	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526218004891	MarR family; Region: MarR_2; pfam12802
526218004892	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
526218004893	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
526218004894	substrate binding site [chemical binding]; other site
526218004895	hexamer interface [polypeptide binding]; other site
526218004896	metal binding site [ion binding]; metal-binding site
526218004897	GTPase RsgA; Reviewed; Region: PRK00098
526218004898	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
526218004899	RNA binding site [nucleotide binding]; other site
526218004900	homodimer interface [polypeptide binding]; other site
526218004901	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
526218004902	GTPase/Zn-binding domain interface [polypeptide binding]; other site
526218004903	GTP/Mg2+ binding site [chemical binding]; other site
526218004904	G4 box; other site
526218004905	G5 box; other site
526218004906	G1 box; other site
526218004907	Switch I region; other site
526218004908	G2 box; other site
526218004909	G3 box; other site
526218004910	Switch II region; other site
526218004911	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
526218004912	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
526218004913	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
526218004914	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
526218004915	active site
526218004916	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
526218004917	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526218004918	S-adenosylmethionine binding site [chemical binding]; other site
526218004919	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
526218004920	active site
526218004921	KH domain; Region: KH_4; pfam13083
526218004922	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
526218004923	RimM N-terminal domain; Region: RimM; pfam01782
526218004924	PRC-barrel domain; Region: PRC; pfam05239
526218004925	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
526218004926	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
526218004927	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
526218004928	trimer interface [polypeptide binding]; other site
526218004929	putative metal binding site [ion binding]; other site
526218004930	SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; pfam09936
526218004931	Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127
526218004932	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
526218004933	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
526218004934	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
526218004935	dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364
526218004936	active pocket/dimerization site; other site
526218004937	active site
526218004938	phosphorylation site [posttranslational modification]
526218004939	glycerol kinase; Provisional; Region: glpK; PRK00047
526218004940	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
526218004941	N- and C-terminal domain interface [polypeptide binding]; other site
526218004942	active site
526218004943	MgATP binding site [chemical binding]; other site
526218004944	catalytic site [active]
526218004945	metal binding site [ion binding]; metal-binding site
526218004946	glycerol binding site [chemical binding]; other site
526218004947	homotetramer interface [polypeptide binding]; other site
526218004948	homodimer interface [polypeptide binding]; other site
526218004949	FBP binding site [chemical binding]; other site
526218004950	protein IIAGlc interface [polypeptide binding]; other site
526218004951	Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954
526218004952	Domain of unknown function DUF77; Region: DUF77; pfam01910
526218004953	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
526218004954	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526218004955	dimer interface [polypeptide binding]; other site
526218004956	conserved gate region; other site
526218004957	putative PBP binding loops; other site
526218004958	ABC-ATPase subunit interface; other site
526218004959	NMT1/THI5 like; Region: NMT1; pfam09084
526218004960	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
526218004961	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
526218004962	Walker A/P-loop; other site
526218004963	ATP binding site [chemical binding]; other site
526218004964	Q-loop/lid; other site
526218004965	ABC transporter signature motif; other site
526218004966	Walker B; other site
526218004967	D-loop; other site
526218004968	H-loop/switch region; other site
526218004969	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
526218004970	active site
526218004971	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
526218004972	ABC1 family; Region: ABC1; cl17513
526218004973	Domain of unknown function (DUF4253); Region: DUF4253; pfam14062
526218004974	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
526218004975	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
526218004976	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
526218004977	Outer membrane efflux protein; Region: OEP; pfam02321
526218004978	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
526218004979	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
526218004980	HlyD family secretion protein; Region: HlyD_3; pfam13437
526218004981	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
526218004982	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
526218004983	Walker A/P-loop; other site
526218004984	ATP binding site [chemical binding]; other site
526218004985	Q-loop/lid; other site
526218004986	ABC transporter signature motif; other site
526218004987	Walker B; other site
526218004988	D-loop; other site
526218004989	H-loop/switch region; other site
526218004990	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
526218004991	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
526218004992	FtsX-like permease family; Region: FtsX; pfam02687
526218004993	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
526218004994	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526218004995	Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674
526218004996	Protein of unknown function (DUF554); Region: DUF554; pfam04474
526218004997	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
526218004998	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
526218004999	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
526218005000	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526218005001	FeS/SAM binding site; other site
526218005002	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
526218005003	active site
526218005004	dimer interfaces [polypeptide binding]; other site
526218005005	catalytic residues [active]
526218005006	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
526218005007	putative active site [active]
526218005008	putative CoA binding site [chemical binding]; other site
526218005009	nudix motif; other site
526218005010	metal binding site [ion binding]; metal-binding site
526218005011	tRNAHis guanylyltransferase; Region: Thg1; pfam04446
526218005012	Thg1 C terminal domain; Region: Thg1C; pfam14413
526218005013	AAA domain; Region: AAA_33; pfam13671
526218005014	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
526218005015	DNA polymerase III PolC; Validated; Region: polC; PRK00448
526218005016	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
526218005017	generic binding surface II; other site
526218005018	generic binding surface I; other site
526218005019	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
526218005020	active site
526218005021	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
526218005022	active site
526218005023	catalytic site [active]
526218005024	substrate binding site [chemical binding]; other site
526218005025	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
526218005026	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
526218005027	galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622
526218005028	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
526218005029	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
526218005030	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
526218005031	putative active site [active]
526218005032	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
526218005033	Sulfatase; Region: Sulfatase; pfam00884
526218005034	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
526218005035	active pocket/dimerization site; other site
526218005036	active site
526218005037	phosphorylation site [posttranslational modification]
526218005038	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
526218005039	active site
526218005040	phosphorylation site [posttranslational modification]
526218005041	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
526218005042	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
526218005043	arylsulfatase; Provisional; Region: PRK13759
526218005044	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
526218005045	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
526218005046	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526218005047	FeS/SAM binding site; other site
526218005048	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
526218005049	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
526218005050	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
526218005051	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
526218005052	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
526218005053	Potassium binding sites [ion binding]; other site
526218005054	Cesium cation binding sites [ion binding]; other site
526218005055	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
526218005056	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
526218005057	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
526218005058	dimerization interface [polypeptide binding]; other site
526218005059	ATP binding site [chemical binding]; other site
526218005060	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
526218005061	dimerization interface [polypeptide binding]; other site
526218005062	ATP binding site [chemical binding]; other site
526218005063	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
526218005064	putative active site [active]
526218005065	catalytic triad [active]
526218005066	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
526218005067	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
526218005068	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
526218005069	ATP binding site [chemical binding]; other site
526218005070	active site
526218005071	substrate binding site [chemical binding]; other site
526218005072	amidophosphoribosyltransferase; Provisional; Region: PRK05793
526218005073	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
526218005074	active site
526218005075	tetramer interface [polypeptide binding]; other site
526218005076	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
526218005077	active site
526218005078	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
526218005079	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
526218005080	dimerization interface [polypeptide binding]; other site
526218005081	putative ATP binding site [chemical binding]; other site
526218005082	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
526218005083	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
526218005084	active site
526218005085	substrate binding site [chemical binding]; other site
526218005086	cosubstrate binding site; other site
526218005087	catalytic site [active]
526218005088	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
526218005089	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
526218005090	purine monophosphate binding site [chemical binding]; other site
526218005091	dimer interface [polypeptide binding]; other site
526218005092	putative catalytic residues [active]
526218005093	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
526218005094	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
526218005095	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
526218005096	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
526218005097	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
526218005098	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
526218005099	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
526218005100	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
526218005101	active site
526218005102	catalytic site [active]
526218005103	substrate binding site [chemical binding]; other site
526218005104	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
526218005105	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
526218005106	substrate binding pocket [chemical binding]; other site
526218005107	membrane-bound complex binding site; other site
526218005108	hinge residues; other site
526218005109	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526218005110	dimer interface [polypeptide binding]; other site
526218005111	conserved gate region; other site
526218005112	putative PBP binding loops; other site
526218005113	ABC-ATPase subunit interface; other site
526218005114	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
526218005115	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
526218005116	Walker A/P-loop; other site
526218005117	ATP binding site [chemical binding]; other site
526218005118	Q-loop/lid; other site
526218005119	ABC transporter signature motif; other site
526218005120	Walker B; other site
526218005121	D-loop; other site
526218005122	H-loop/switch region; other site
526218005123	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
526218005124	Peptidase family M23; Region: Peptidase_M23; pfam01551
526218005125	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
526218005126	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
526218005127	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
526218005128	Walker A/P-loop; other site
526218005129	ATP binding site [chemical binding]; other site
526218005130	Q-loop/lid; other site
526218005131	ABC transporter signature motif; other site
526218005132	Walker B; other site
526218005133	D-loop; other site
526218005134	H-loop/switch region; other site
526218005135	NIL domain; Region: NIL; pfam09383
526218005136	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526218005137	dimer interface [polypeptide binding]; other site
526218005138	conserved gate region; other site
526218005139	ABC-ATPase subunit interface; other site
526218005140	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
526218005141	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
526218005142	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
526218005143	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
526218005144	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
526218005145	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
526218005146	Walker A/P-loop; other site
526218005147	ATP binding site [chemical binding]; other site
526218005148	Q-loop/lid; other site
526218005149	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
526218005150	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
526218005151	ABC transporter signature motif; other site
526218005152	Walker B; other site
526218005153	D-loop; other site
526218005154	H-loop/switch region; other site
526218005155	VacJ like lipoprotein; Region: VacJ; cl01073
526218005156	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218005157	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
526218005158	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
526218005159	active site
526218005160	dimer interface [polypeptide binding]; other site
526218005161	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
526218005162	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
526218005163	active site
526218005164	trimer interface [polypeptide binding]; other site
526218005165	allosteric site; other site
526218005166	active site lid [active]
526218005167	hexamer (dimer of trimers) interface [polypeptide binding]; other site
526218005168	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
526218005169	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
526218005170	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
526218005171	putative active site [active]
526218005172	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
526218005173	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
526218005174	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
526218005175	active site turn [active]
526218005176	phosphorylation site [posttranslational modification]
526218005177	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
526218005178	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
526218005179	Uncharacterized conserved protein [Function unknown]; Region: COG3589
526218005180	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
526218005181	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
526218005182	TPR motif; other site
526218005183	binding surface
526218005184	Uncharacterized conserved protein [Function unknown]; Region: COG1434
526218005185	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
526218005186	putative active site [active]
526218005187	Chromate transporter; Region: Chromate_transp; pfam02417
526218005188	Chromate transporter; Region: Chromate_transp; pfam02417
526218005189	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
526218005190	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
526218005191	ligand binding site; other site
526218005192	oligomer interface; other site
526218005193	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
526218005194	dimer interface [polypeptide binding]; other site
526218005195	N-terminal domain interface [polypeptide binding]; other site
526218005196	sulfate 1 binding site; other site
526218005197	glycogen synthase; Provisional; Region: glgA; PRK00654
526218005198	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
526218005199	ADP-binding pocket [chemical binding]; other site
526218005200	homodimer interface [polypeptide binding]; other site
526218005201	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
526218005202	Catalytic site [active]
526218005203	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
526218005204	active site
526218005205	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
526218005206	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
526218005207	GDP-binding site [chemical binding]; other site
526218005208	ACT binding site; other site
526218005209	IMP binding site; other site
526218005210	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
526218005211	Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302
526218005212	tetramer interface [polypeptide binding]; other site
526218005213	active site
526218005214	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
526218005215	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526218005216	putative metal binding site [ion binding]; other site
526218005217	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
526218005218	active site
526218005219	aconitate hydratase; Validated; Region: PRK07229
526218005220	Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585
526218005221	substrate binding site [chemical binding]; other site
526218005222	ligand binding site [chemical binding]; other site
526218005223	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
526218005224	substrate binding site [chemical binding]; other site
526218005225	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
526218005226	tartrate dehydrogenase; Region: TTC; TIGR02089
526218005227	citrate synthase; Provisional; Region: PRK14032
526218005228	Citrate synthase; Region: Citrate_synt; pfam00285
526218005229	oxalacetate binding site [chemical binding]; other site
526218005230	citrylCoA binding site [chemical binding]; other site
526218005231	coenzyme A binding site [chemical binding]; other site
526218005232	catalytic triad [active]
526218005233	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
526218005234	catalytic core [active]
526218005235	Uncharacterized conserved protein [Function unknown]; Region: COG1434
526218005236	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
526218005237	putative active site [active]
526218005238	NAD-dependent deacetylase; Provisional; Region: PRK00481
526218005239	SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407
526218005240	NAD+ binding site [chemical binding]; other site
526218005241	substrate binding site [chemical binding]; other site
526218005242	Zn binding site [ion binding]; other site
526218005243	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
526218005244	Domain of unknown function DUF21; Region: DUF21; pfam01595
526218005245	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
526218005246	Transporter associated domain; Region: CorC_HlyC; pfam03471
526218005247	Protein of unknown function (DUF523); Region: DUF523; pfam04463
526218005248	Cupin domain; Region: Cupin_2; pfam07883
526218005249	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526218005250	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
526218005251	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526218005252	active site
526218005253	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
526218005254	MOSC domain; Region: MOSC; pfam03473
526218005255	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
526218005256	putative ADP-ribose binding site [chemical binding]; other site
526218005257	putative active site [active]
526218005258	allantoate amidohydrolase; Reviewed; Region: PRK09290
526218005259	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
526218005260	active site
526218005261	metal binding site [ion binding]; metal-binding site
526218005262	dimer interface [polypeptide binding]; other site
526218005263	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
526218005264	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
526218005265	homodimer interface [polypeptide binding]; other site
526218005266	substrate-cofactor binding pocket; other site
526218005267	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526218005268	catalytic residue [active]
526218005269	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
526218005270	FAD binding site [chemical binding]; other site
526218005271	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
526218005272	conserved cys residue [active]
526218005273	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
526218005274	ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443
526218005275	dimer interface [polypeptide binding]; other site
526218005276	motif 1; other site
526218005277	active site
526218005278	motif 2; other site
526218005279	motif 3; other site
526218005280	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
526218005281	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
526218005282	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
526218005283	histidinol dehydrogenase; Region: hisD; TIGR00069
526218005284	NAD binding site [chemical binding]; other site
526218005285	dimerization interface [polypeptide binding]; other site
526218005286	product binding site; other site
526218005287	substrate binding site [chemical binding]; other site
526218005288	zinc binding site [ion binding]; other site
526218005289	catalytic residues [active]
526218005290	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
526218005291	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
526218005292	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526218005293	homodimer interface [polypeptide binding]; other site
526218005294	catalytic residue [active]
526218005295	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
526218005296	putative active site pocket [active]
526218005297	4-fold oligomerization interface [polypeptide binding]; other site
526218005298	metal binding residues [ion binding]; metal-binding site
526218005299	3-fold/trimer interface [polypeptide binding]; other site
526218005300	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
526218005301	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
526218005302	putative active site [active]
526218005303	oxyanion strand; other site
526218005304	catalytic triad [active]
526218005305	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
526218005306	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
526218005307	catalytic residues [active]
526218005308	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
526218005309	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
526218005310	substrate binding site [chemical binding]; other site
526218005311	glutamase interaction surface [polypeptide binding]; other site
526218005312	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
526218005313	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
526218005314	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
526218005315	metal binding site [ion binding]; metal-binding site
526218005316	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
526218005317	histidinol-phosphatase; Reviewed; Region: PRK08123
526218005318	active site
526218005319	dimer interface [polypeptide binding]; other site
526218005320	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
526218005321	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
526218005322	active site
526218005323	multimer interface [polypeptide binding]; other site
526218005324	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
526218005325	predicted active site [active]
526218005326	catalytic triad [active]
526218005327	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
526218005328	Tic20-like protein; Region: Tic20; pfam09685
526218005329	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
526218005330	active site
526218005331	DNA binding site [nucleotide binding]
526218005332	Protein of unknown function (DUF_B2219); Region: PPO1_KFDV; pfam12143
526218005333	Predicted acetyltransferase [General function prediction only]; Region: COG3153
526218005334	Coenzyme A binding pocket [chemical binding]; other site
526218005335	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
526218005336	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
526218005337	Cl- selectivity filter; other site
526218005338	Cl- binding residues [ion binding]; other site
526218005339	pore gating glutamate residue; other site
526218005340	dimer interface [polypeptide binding]; other site
526218005341	H+/Cl- coupling transport residue; other site
526218005342	TrkA-C domain; Region: TrkA_C; pfam02080
526218005343	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
526218005344	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
526218005345	active site
526218005346	Riboflavin kinase; Region: Flavokinase; pfam01687
526218005347	ScpA/B protein; Region: ScpA_ScpB; cl00598
526218005348	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
526218005349	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
526218005350	Transcriptional regulator [Transcription]; Region: LysR; COG0583
526218005351	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
526218005352	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
526218005353	putative dimerization interface [polypeptide binding]; other site
526218005354	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
526218005355	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
526218005356	GTP-binding protein LepA; Provisional; Region: PRK05433
526218005357	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
526218005358	G1 box; other site
526218005359	putative GEF interaction site [polypeptide binding]; other site
526218005360	GTP/Mg2+ binding site [chemical binding]; other site
526218005361	Switch I region; other site
526218005362	G2 box; other site
526218005363	G3 box; other site
526218005364	Switch II region; other site
526218005365	G4 box; other site
526218005366	G5 box; other site
526218005367	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
526218005368	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
526218005369	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
526218005370	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267
526218005371	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
526218005372	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
526218005373	P-loop; other site
526218005374	Magnesium ion binding site [ion binding]; other site
526218005375	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
526218005376	NusB family; Region: NusB; pfam01029
526218005377	16S rRNA methyltransferase B; Provisional; Region: PRK14902
526218005378	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526218005379	S-adenosylmethionine binding site [chemical binding]; other site
526218005380	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
526218005381	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
526218005382	active site
526218005383	NTP binding site [chemical binding]; other site
526218005384	metal binding triad [ion binding]; metal-binding site
526218005385	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
526218005386	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
526218005387	Zn2+ binding site [ion binding]; other site
526218005388	Mg2+ binding site [ion binding]; other site
526218005389	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428
526218005390	active site
526218005391	Ap4A binding cleft/pocket [chemical binding]; other site
526218005392	P4 phosphate binding site; other site
526218005393	nudix motif; other site
526218005394	putative P2/P3 phosphate binding site [ion binding]; other site
526218005395	endonuclease IV; Provisional; Region: PRK01060
526218005396	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
526218005397	AP (apurinic/apyrimidinic) site pocket; other site
526218005398	DNA interaction; other site
526218005399	Metal-binding active site; metal-binding site
526218005400	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b; cd09180
526218005401	PLD-like domain; Region: PLDc_2; pfam13091
526218005402	putative homodimer interface [polypeptide binding]; other site
526218005403	putative active site [active]
526218005404	catalytic site [active]
526218005405	DEAD-like helicases superfamily; Region: DEXDc; smart00487
526218005406	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526218005407	ATP binding site [chemical binding]; other site
526218005408	putative Mg++ binding site [ion binding]; other site
526218005409	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526218005410	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
526218005411	nucleotide binding region [chemical binding]; other site
526218005412	ATP-binding site [chemical binding]; other site
526218005413	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
526218005414	Predicted membrane protein [Function unknown]; Region: COG2860
526218005415	UPF0126 domain; Region: UPF0126; pfam03458
526218005416	UPF0126 domain; Region: UPF0126; pfam03458
526218005417	exopolyphosphatase; Region: exo_poly_only; TIGR03706
526218005418	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
526218005419	nucleotide binding site [chemical binding]; other site
526218005420	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
526218005421	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
526218005422	nucleotide binding site/active site [active]
526218005423	HIT family signature motif; other site
526218005424	catalytic residue [active]
526218005425	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
526218005426	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
526218005427	DKNYY family; Region: DKNYY; pfam13644
526218005428	DKNYY family; Region: DKNYY; pfam13644
526218005429	DKNYY family; Region: DKNYY; pfam13644
526218005430	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218005431	binding surface
526218005432	TPR motif; other site
526218005433	Tetratricopeptide repeat; Region: TPR_12; pfam13424
526218005434	TPR repeat; Region: TPR_11; pfam13414
526218005435	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
526218005436	binding surface
526218005437	TPR motif; other site
526218005438	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526218005439	Coenzyme A binding pocket [chemical binding]; other site
526218005440	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
526218005441	dimer interface [polypeptide binding]; other site
526218005442	DKNYY family; Region: DKNYY; pfam13644
526218005443	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
526218005444	active site
526218005445	metal binding site [ion binding]; metal-binding site
526218005446	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526218005447	DKNYY family; Region: DKNYY; pfam13644
526218005448	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
526218005449	putative dimer interface [polypeptide binding]; other site
526218005450	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526218005451	ligand binding site [chemical binding]; other site
526218005452	Zn binding site [ion binding]; other site
526218005453	Gas vesicle protein G; Region: GvpG; pfam05120
526218005454	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
526218005455	pentamer interface [polypeptide binding]; other site
526218005456	dodecaamer interface [polypeptide binding]; other site
526218005457	Electron transfer DM13; Region: DM13; cl02735
526218005458	aspartate aminotransferase; Provisional; Region: PRK07568
526218005459	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
526218005460	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526218005461	homodimer interface [polypeptide binding]; other site
526218005462	catalytic residue [active]
526218005463	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
526218005464	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
526218005465	amidase catalytic site [active]
526218005466	Zn binding residues [ion binding]; other site
526218005467	substrate binding site [chemical binding]; other site
526218005468	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
526218005469	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
526218005470	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218005471	TPR motif; other site
526218005472	binding surface
526218005473	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
526218005474	homodimer interface [polypeptide binding]; other site
526218005475	chemical substrate binding site [chemical binding]; other site
526218005476	oligomer interface [polypeptide binding]; other site
526218005477	metal binding site [ion binding]; metal-binding site
526218005478	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
526218005479	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
526218005480	Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939
526218005481	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
526218005482	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
526218005483	putative ATP binding site [chemical binding]; other site
526218005484	putative substrate interface [chemical binding]; other site
526218005485	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
526218005486	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
526218005487	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
526218005488	Cl binding site [ion binding]; other site
526218005489	oligomer interface [polypeptide binding]; other site
526218005490	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
526218005491	catalytic core [active]
526218005492	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
526218005493	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
526218005494	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
526218005495	S-adenosylmethionine binding site [chemical binding]; other site
526218005496	methionine sulfoxide reductase A; Provisional; Region: PRK14054
526218005497	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
526218005498	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
526218005499	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526218005500	active site
526218005501	motif I; other site
526218005502	motif II; other site
526218005503	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
526218005504	putative uracil/xanthine transporter; Provisional; Region: PRK11412
526218005505	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
526218005506	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
526218005507	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
526218005508	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
526218005509	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
526218005510	Rubrerythrin [Energy production and conversion]; Region: COG1592
526218005511	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
526218005512	binuclear metal center [ion binding]; other site
526218005513	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
526218005514	iron binding site [ion binding]; other site
526218005515	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
526218005516	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526218005517	motif II; other site
526218005518	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
526218005519	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526218005520	motif II; other site
526218005521	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
526218005522	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
526218005523	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526218005524	catalytic residue [active]
526218005525	argininosuccinate lyase; Provisional; Region: PRK00855
526218005526	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
526218005527	active sites [active]
526218005528	tetramer interface [polypeptide binding]; other site
526218005529	argininosuccinate synthase; Provisional; Region: PRK13820
526218005530	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
526218005531	ANP binding site [chemical binding]; other site
526218005532	Substrate Binding Site II [chemical binding]; other site
526218005533	Substrate Binding Site I [chemical binding]; other site
526218005534	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
526218005535	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
526218005536	binding surface
526218005537	TPR motif; other site
526218005538	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
526218005539	TPR motif; other site
526218005540	binding surface
526218005541	Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_1; cd09129
526218005542	putative active site [active]
526218005543	putative catalytic site [active]
526218005544	Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_2; cd09130
526218005545	PLD-like domain; Region: PLDc_2; pfam13091
526218005546	putative active site [active]
526218005547	putative catalytic site [active]
526218005548	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
526218005549	putative active site [active]
526218005550	putative catalytic site [active]
526218005551	putative Mg binding site IVb [ion binding]; other site
526218005552	putative phosphate binding site [ion binding]; other site
526218005553	putative DNA binding site [nucleotide binding]; other site
526218005554	putative Mg binding site IVa [ion binding]; other site
526218005555	elongation factor P; Validated; Region: PRK00529
526218005556	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
526218005557	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
526218005558	RNA binding site [nucleotide binding]; other site
526218005559	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
526218005560	RNA binding site [nucleotide binding]; other site
526218005561	Protein of unknown function (DUF1294); Region: DUF1294; cl01311
526218005562	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526218005563	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
526218005564	Walker A/P-loop; other site
526218005565	ATP binding site [chemical binding]; other site
526218005566	Q-loop/lid; other site
526218005567	ABC transporter signature motif; other site
526218005568	Walker B; other site
526218005569	D-loop; other site
526218005570	H-loop/switch region; other site
526218005571	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
526218005572	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
526218005573	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
526218005574	Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_1; cd09129
526218005575	putative active site [active]
526218005576	putative catalytic site [active]
526218005577	Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_2; cd09130
526218005578	PLD-like domain; Region: PLDc_2; pfam13091
526218005579	putative active site [active]
526218005580	putative catalytic site [active]
526218005581	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526218005582	Major Facilitator Superfamily; Region: MFS_1; pfam07690
526218005583	putative substrate translocation pore; other site
526218005584	Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328
526218005585	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
526218005586	Peptidase family U32; Region: Peptidase_U32; pfam01136
526218005587	Collagenase; Region: DUF3656; pfam12392
526218005588	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
526218005589	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
526218005590	dimer interface [polypeptide binding]; other site
526218005591	substrate binding site [chemical binding]; other site
526218005592	ATP binding site [chemical binding]; other site
526218005593	Autotransporter beta-domain; Region: Autotransporter; smart00869
526218005594	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
526218005595	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526218005596	Radical SAM superfamily; Region: Radical_SAM; pfam04055
526218005597	FeS/SAM binding site; other site
526218005598	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
526218005599	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
526218005600	Ribosomal protein L7/L12 [Translation, ribosomal structure and biogenesis]; Region: RplL; COG0222
526218005601	L11 interface [polypeptide binding]; other site
526218005602	putative EF-Tu interaction site [polypeptide binding]; other site
526218005603	putative EF-G interaction site [polypeptide binding]; other site
526218005604	Predicted transcriptional regulator [Transcription]; Region: COG2378
526218005605	HTH domain; Region: HTH_11; pfam08279
526218005606	WYL domain; Region: WYL; pfam13280
526218005607	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
526218005608	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
526218005609	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
526218005610	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
526218005611	G1 box; other site
526218005612	GTP/Mg2+ binding site [chemical binding]; other site
526218005613	Switch I region; other site
526218005614	G2 box; other site
526218005615	G3 box; other site
526218005616	Switch II region; other site
526218005617	G4 box; other site
526218005618	G5 box; other site
526218005619	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
526218005620	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
526218005621	Walker A/P-loop; other site
526218005622	ATP binding site [chemical binding]; other site
526218005623	Q-loop/lid; other site
526218005624	ABC transporter signature motif; other site
526218005625	Walker B; other site
526218005626	D-loop; other site
526218005627	H-loop/switch region; other site
526218005628	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
526218005629	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526218005630	dimer interface [polypeptide binding]; other site
526218005631	conserved gate region; other site
526218005632	putative PBP binding loops; other site
526218005633	ABC-ATPase subunit interface; other site
526218005634	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
526218005635	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
526218005636	substrate binding pocket [chemical binding]; other site
526218005637	membrane-bound complex binding site; other site
526218005638	hinge residues; other site
526218005639	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
526218005640	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
526218005641	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526218005642	MarR family; Region: MarR_2; cl17246
526218005643	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
526218005644	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
526218005645	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526218005646	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526218005647	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
526218005648	Found in ATP-dependent protease La (LON); Region: LON; smart00464
526218005649	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526218005650	Walker A motif; other site
526218005651	ATP binding site [chemical binding]; other site
526218005652	Walker B motif; other site
526218005653	arginine finger; other site
526218005654	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
526218005655	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
526218005656	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
526218005657	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526218005658	Walker A motif; other site
526218005659	ATP binding site [chemical binding]; other site
526218005660	Walker B motif; other site
526218005661	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
526218005662	Clp protease; Region: CLP_protease; pfam00574
526218005663	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
526218005664	oligomer interface [polypeptide binding]; other site
526218005665	active site residues [active]
526218005666	trigger factor; Provisional; Region: tig; PRK01490
526218005667	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
526218005668	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
526218005669	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
526218005670	DHH family; Region: DHH; pfam01368
526218005671	DHHA1 domain; Region: DHHA1; pfam02272
526218005672	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
526218005673	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
526218005674	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
526218005675	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
526218005676	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
526218005677	G1 box; other site
526218005678	putative GEF interaction site [polypeptide binding]; other site
526218005679	GTP/Mg2+ binding site [chemical binding]; other site
526218005680	Switch I region; other site
526218005681	G2 box; other site
526218005682	G3 box; other site
526218005683	Switch II region; other site
526218005684	G4 box; other site
526218005685	G5 box; other site
526218005686	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
526218005687	Translation-initiation factor 2; Region: IF-2; pfam11987
526218005688	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
526218005689	Protein of unknown function (DUF448); Region: DUF448; pfam04296
526218005690	putative RNA binding cleft [nucleotide binding]; other site
526218005691	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
526218005692	NusA N-terminal domain; Region: NusA_N; pfam08529
526218005693	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
526218005694	RNA binding site [nucleotide binding]; other site
526218005695	homodimer interface [polypeptide binding]; other site
526218005696	Transcription elongation factor [Transcription]; Region: NusA; COG0195
526218005697	NusA-like KH domain; Region: KH_5; pfam13184
526218005698	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
526218005699	G-X-X-G motif; other site
526218005700	ribosome maturation protein RimP; Reviewed; Region: PRK00092
526218005701	Sm and related proteins; Region: Sm_like; cl00259
526218005702	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
526218005703	putative oligomer interface [polypeptide binding]; other site
526218005704	putative RNA binding site [nucleotide binding]; other site
526218005705	tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431
526218005706	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
526218005707	RNA binding site [nucleotide binding]; other site
526218005708	active site
526218005709	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
526218005710	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
526218005711	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
526218005712	putative active site [active]
526218005713	catalytic site [active]
526218005714	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
526218005715	putative active site [active]
526218005716	catalytic site [active]
526218005717	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
526218005718	dimerization interface [polypeptide binding]; other site
526218005719	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
526218005720	dimer interface [polypeptide binding]; other site
526218005721	phosphorylation site [posttranslational modification]
526218005722	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526218005723	ATP binding site [chemical binding]; other site
526218005724	Mg2+ binding site [ion binding]; other site
526218005725	G-X-G motif; other site
526218005726	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
526218005727	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526218005728	active site
526218005729	phosphorylation site [posttranslational modification]
526218005730	intermolecular recognition site; other site
526218005731	dimerization interface [polypeptide binding]; other site
526218005732	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
526218005733	DNA binding site [nucleotide binding]
526218005734	DNA-binding protein, stimulates sugar fermentation [General function prediction only]; Region: SfsA; COG1489
526218005735	ribonuclease PH; Reviewed; Region: rph; PRK00173
526218005736	Ribonuclease PH; Region: RNase_PH_bact; cd11362
526218005737	hexamer interface [polypeptide binding]; other site
526218005738	active site
526218005739	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
526218005740	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
526218005741	dimer interface [polypeptide binding]; other site
526218005742	active site
526218005743	glycine-pyridoxal phosphate binding site [chemical binding]; other site
526218005744	folate binding site [chemical binding]; other site
526218005745	competence damage-inducible protein A; Provisional; Region: PRK00549
526218005746	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
526218005747	putative MPT binding site; other site
526218005748	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
526218005749	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
526218005750	classical (c) SDRs; Region: SDR_c; cd05233
526218005751	NAD(P) binding site [chemical binding]; other site
526218005752	active site
526218005753	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
526218005754	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
526218005755	DNA binding residues [nucleotide binding]
526218005756	dimer interface [polypeptide binding]; other site
526218005757	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
526218005758	Autotransporter beta-domain; Region: Autotransporter; smart00869
526218005759	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
526218005760	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
526218005761	catalytic triad [active]
526218005762	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
526218005763	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
526218005764	Walker A/P-loop; other site
526218005765	ATP binding site [chemical binding]; other site
526218005766	Q-loop/lid; other site
526218005767	ABC transporter signature motif; other site
526218005768	Walker B; other site
526218005769	D-loop; other site
526218005770	H-loop/switch region; other site
526218005771	Predicted transcriptional regulators [Transcription]; Region: COG1725
526218005772	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526218005773	DNA-binding site [nucleotide binding]; DNA binding site
526218005774	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
526218005775	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
526218005776	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
526218005777	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
526218005778	active site
526218005779	dimer interface [polypeptide binding]; other site
526218005780	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
526218005781	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
526218005782	active site
526218005783	FMN binding site [chemical binding]; other site
526218005784	substrate binding site [chemical binding]; other site
526218005785	3Fe-4S cluster binding site [ion binding]; other site
526218005786	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
526218005787	domain interface; other site
526218005788	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
526218005789	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
526218005790	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
526218005791	Domain of unknown function (DUF4259); Region: DUF4259; pfam14078
526218005792	Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381
526218005793	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
526218005794	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
526218005795	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
526218005796	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
526218005797	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
526218005798	Walker A/P-loop; other site
526218005799	ATP binding site [chemical binding]; other site
526218005800	Q-loop/lid; other site
526218005801	ABC transporter signature motif; other site
526218005802	Walker B; other site
526218005803	D-loop; other site
526218005804	H-loop/switch region; other site
526218005805	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
526218005806	Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763
526218005807	Protein of unknown function (DUF1009); Region: DUF1009; cl09182
526218005808	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
526218005809	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
526218005810	active site
526218005811	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
526218005812	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
526218005813	active site
526218005814	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
526218005815	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
526218005816	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
526218005817	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
526218005818	Part of AAA domain; Region: AAA_19; pfam13245
526218005819	Family description; Region: UvrD_C_2; pfam13538
526218005820	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526218005821	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
526218005822	Coenzyme A binding pocket [chemical binding]; other site
526218005823	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
526218005824	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
526218005825	Predicted periplasmic protein [Function unknown]; Region: COG3698
526218005826	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
526218005827	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
526218005828	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
526218005829	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
526218005830	putative acyl-acceptor binding pocket; other site
526218005831	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218005832	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
526218005833	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
526218005834	Ligand binding site; other site
526218005835	oligomer interface; other site
526218005836	YcxB-like protein; Region: YcxB; pfam14317
526218005837	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
526218005838	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526218005839	Walker A/P-loop; other site
526218005840	ATP binding site [chemical binding]; other site
526218005841	Q-loop/lid; other site
526218005842	ABC transporter signature motif; other site
526218005843	Walker B; other site
526218005844	D-loop; other site
526218005845	H-loop/switch region; other site
526218005846	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
526218005847	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
526218005848	TM-ABC transporter signature motif; other site
526218005849	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
526218005850	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
526218005851	zinc binding site [ion binding]; other site
526218005852	putative ligand binding site [chemical binding]; other site
526218005853	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
526218005854	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
526218005855	zinc binding site [ion binding]; other site
526218005856	putative ligand binding site [chemical binding]; other site
526218005857	Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640
526218005858	hexamer interface [polypeptide binding]; other site
526218005859	RNA binding site [nucleotide binding]; other site
526218005860	Histidine-zinc binding site [chemical binding]; other site
526218005861	Dehydroquinase class II; Region: DHquinase_II; pfam01220
526218005862	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
526218005863	trimer interface [polypeptide binding]; other site
526218005864	active site
526218005865	dimer interface [polypeptide binding]; other site
526218005866	shikimate kinase; Reviewed; Region: aroK; PRK00131
526218005867	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
526218005868	ADP binding site [chemical binding]; other site
526218005869	magnesium binding site [ion binding]; other site
526218005870	putative shikimate binding site; other site
526218005871	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
526218005872	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
526218005873	active site
526218005874	catalytic tetrad [active]
526218005875	Domain of unknown function (DUF4250); Region: DUF4250; pfam14056
526218005876	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
526218005877	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
526218005878	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
526218005879	shikimate binding site; other site
526218005880	NAD(P) binding site [chemical binding]; other site
526218005881	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
526218005882	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
526218005883	RNA binding surface [nucleotide binding]; other site
526218005884	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
526218005885	active site
526218005886	uracil binding [chemical binding]; other site
526218005887	hypothetical protein; Provisional; Region: PRK07248
526218005888	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
526218005889	Prephenate dehydratase; Region: PDT; pfam00800
526218005890	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
526218005891	putative L-Phe binding site [chemical binding]; other site
526218005892	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
526218005893	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
526218005894	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
526218005895	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
526218005896	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
526218005897	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
526218005898	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
526218005899	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526218005900	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
526218005901	dimer interface [polypeptide binding]; other site
526218005902	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526218005903	Protein of unknown function (DUF975); Region: DUF975; cl10504
526218005904	HTH domain; Region: HTH_11; pfam08279
526218005905	FOG: CBS domain [General function prediction only]; Region: COG0517
526218005906	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
526218005907	PEP synthetase regulatory protein; Provisional; Region: PRK05339
526218005908	pyruvate phosphate dikinase; Provisional; Region: PRK09279
526218005909	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
526218005910	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
526218005911	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
526218005912	Methyltransferase domain; Region: Methyltransf_23; pfam13489
526218005913	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526218005914	S-adenosylmethionine binding site [chemical binding]; other site
526218005915	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
526218005916	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526218005917	NAD(P) binding site [chemical binding]; other site
526218005918	active site
526218005919	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
526218005920	Integral membrane protein DUF92; Region: DUF92; cl00793
526218005921	Bacterial sugar transferase; Region: Bac_transf; pfam02397
526218005922	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
526218005923	active site
526218005924	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
526218005925	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
526218005926	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
526218005927	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
526218005928	active site
526218005929	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
526218005930	putative catalytic site [active]
526218005931	putative metal binding site [ion binding]; other site
526218005932	putative phosphate binding site [ion binding]; other site
526218005933	Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774
526218005934	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
526218005935	O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296
526218005936	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
526218005937	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
526218005938	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
526218005939	GTPase CgtA; Reviewed; Region: obgE; PRK12297
526218005940	GTP1/OBG; Region: GTP1_OBG; pfam01018
526218005941	Obg GTPase; Region: Obg; cd01898
526218005942	G1 box; other site
526218005943	GTP/Mg2+ binding site [chemical binding]; other site
526218005944	Switch I region; other site
526218005945	G2 box; other site
526218005946	G3 box; other site
526218005947	Switch II region; other site
526218005948	G4 box; other site
526218005949	G5 box; other site
526218005950	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
526218005951	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
526218005952	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
526218005953	active site
526218005954	tetramer interface; other site
526218005955	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
526218005956	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
526218005957	NAD binding site [chemical binding]; other site
526218005958	substrate binding site [chemical binding]; other site
526218005959	homodimer interface [polypeptide binding]; other site
526218005960	active site
526218005961	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
526218005962	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
526218005963	NADP binding site [chemical binding]; other site
526218005964	active site
526218005965	putative substrate binding site [chemical binding]; other site
526218005966	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
526218005967	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
526218005968	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
526218005969	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
526218005970	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
526218005971	Probable Catalytic site; other site
526218005972	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
526218005973	dimer interface [polypeptide binding]; other site
526218005974	active site
526218005975	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
526218005976	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
526218005977	putative ribose interaction site [chemical binding]; other site
526218005978	putative ADP binding site [chemical binding]; other site
526218005979	Methyltransferase domain; Region: Methyltransf_24; pfam13578
526218005980	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
526218005981	Probable Catalytic site; other site
526218005982	metal-binding site
526218005983	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
526218005984	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
526218005985	Probable Catalytic site; other site
526218005986	metal-binding site
526218005987	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
526218005988	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
526218005989	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
526218005990	Walker A/P-loop; other site
526218005991	ATP binding site [chemical binding]; other site
526218005992	Q-loop/lid; other site
526218005993	ABC transporter signature motif; other site
526218005994	Walker B; other site
526218005995	D-loop; other site
526218005996	H-loop/switch region; other site
526218005997	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
526218005998	putative carbohydrate binding site [chemical binding]; other site
526218005999	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
526218006000	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
526218006001	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
526218006002	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
526218006003	substrate binding site; other site
526218006004	tetramer interface; other site
526218006005	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
526218006006	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
526218006007	active site
526218006008	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
526218006009	Bacterial sugar transferase; Region: Bac_transf; pfam02397
526218006010	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
526218006011	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756
526218006012	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1244
526218006013	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218006014	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
526218006015	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
526218006016	active site turn [active]
526218006017	phosphorylation site [posttranslational modification]
526218006018	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
526218006019	trehalose repressor; Provisional; Region: treR; PRK09492
526218006020	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
526218006021	DNA binding site [nucleotide binding]
526218006022	domain linker motif; other site
526218006023	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
526218006024	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
526218006025	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
526218006026	Tetramer interface [polypeptide binding]; other site
526218006027	active site
526218006028	FMN-binding site [chemical binding]; other site
526218006029	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
526218006030	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
526218006031	hinge; other site
526218006032	active site
526218006033	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
526218006034	active site
526218006035	dimer interface [polypeptide binding]; other site
526218006036	metal binding site [ion binding]; metal-binding site
526218006037	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
526218006038	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
526218006039	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
526218006040	prephenate dehydrogenase; Validated; Region: PRK08507
526218006041	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
526218006042	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
526218006043	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
526218006044	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
526218006045	putative ligand binding site [chemical binding]; other site
526218006046	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
526218006047	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
526218006048	TM-ABC transporter signature motif; other site
526218006049	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
526218006050	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
526218006051	TM-ABC transporter signature motif; other site
526218006052	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
526218006053	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
526218006054	Walker A/P-loop; other site
526218006055	ATP binding site [chemical binding]; other site
526218006056	Q-loop/lid; other site
526218006057	ABC transporter signature motif; other site
526218006058	Walker B; other site
526218006059	D-loop; other site
526218006060	H-loop/switch region; other site
526218006061	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
526218006062	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
526218006063	Walker A/P-loop; other site
526218006064	ATP binding site [chemical binding]; other site
526218006065	Q-loop/lid; other site
526218006066	ABC transporter signature motif; other site
526218006067	Walker B; other site
526218006068	D-loop; other site
526218006069	H-loop/switch region; other site
526218006070	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
526218006071	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
526218006072	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
526218006073	putative active site [active]
526218006074	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
526218006075	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
526218006076	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
526218006077	active site turn [active]
526218006078	phosphorylation site [posttranslational modification]
526218006079	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
526218006080	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
526218006081	putative active site cavity [active]
526218006082	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
526218006083	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
526218006084	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
526218006085	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
526218006086	substrate binding pocket [chemical binding]; other site
526218006087	chain length determination region; other site
526218006088	substrate-Mg2+ binding site; other site
526218006089	catalytic residues [active]
526218006090	aspartate-rich region 1; other site
526218006091	active site lid residues [active]
526218006092	aspartate-rich region 2; other site
526218006093	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
526218006094	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
526218006095	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526218006096	S-adenosylmethionine binding site [chemical binding]; other site
526218006097	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
526218006098	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
526218006099	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218006100	DKNYY family; Region: DKNYY; pfam13644
526218006101	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
526218006102	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526218006103	S-adenosylmethionine binding site [chemical binding]; other site
526218006104	peptide chain release factor 1; Validated; Region: prfA; PRK00591
526218006105	This domain is found in peptide chain release factors; Region: PCRF; smart00937
526218006106	RF-1 domain; Region: RF-1; pfam00472
526218006107	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
526218006108	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
526218006109	substrate binding pocket [chemical binding]; other site
526218006110	membrane-bound complex binding site; other site
526218006111	hinge residues; other site
526218006112	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
526218006113	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
526218006114	Walker A/P-loop; other site
526218006115	ATP binding site [chemical binding]; other site
526218006116	Q-loop/lid; other site
526218006117	ABC transporter signature motif; other site
526218006118	Walker B; other site
526218006119	D-loop; other site
526218006120	H-loop/switch region; other site
526218006121	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
526218006122	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526218006123	dimer interface [polypeptide binding]; other site
526218006124	conserved gate region; other site
526218006125	putative PBP binding loops; other site
526218006126	ABC-ATPase subunit interface; other site
526218006127	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526218006128	Protein of unknown function (DUF1385); Region: DUF1385; cl01595
526218006129	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
526218006130	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
526218006131	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
526218006132	DNA repair protein RadA; Provisional; Region: PRK11823
526218006133	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
526218006134	Walker A motif; other site
526218006135	ATP binding site [chemical binding]; other site
526218006136	Walker B motif; other site
526218006137	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
526218006138	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
526218006139	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
526218006140	active site
526218006141	(T/H)XGH motif; other site
526218006142	ribonuclease III; Reviewed; Region: rnc; PRK00102
526218006143	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
526218006144	dimerization interface [polypeptide binding]; other site
526218006145	active site
526218006146	metal binding site [ion binding]; metal-binding site
526218006147	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
526218006148	dsRNA binding site [nucleotide binding]; other site
526218006149	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
526218006150	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
526218006151	dimer interface [polypeptide binding]; other site
526218006152	active site
526218006153	acyl carrier protein; Provisional; Region: acpP; PRK00982
526218006154	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
526218006155	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
526218006156	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
526218006157	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
526218006158	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
526218006159	dimer interface [polypeptide binding]; other site
526218006160	active site
526218006161	CoA binding pocket [chemical binding]; other site
526218006162	Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333
526218006163	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218006164	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
526218006165	EamA-like transporter family; Region: EamA; pfam00892
526218006166	EamA-like transporter family; Region: EamA; pfam00892
526218006167	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
526218006168	Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078
526218006169	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
526218006170	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
526218006171	G1 box; other site
526218006172	putative GEF interaction site [polypeptide binding]; other site
526218006173	GTP/Mg2+ binding site [chemical binding]; other site
526218006174	Switch I region; other site
526218006175	G2 box; other site
526218006176	G3 box; other site
526218006177	Switch II region; other site
526218006178	G4 box; other site
526218006179	G5 box; other site
526218006180	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
526218006181	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
526218006182	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
526218006183	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
526218006184	amidase catalytic site [active]
526218006185	Zn binding residues [ion binding]; other site
526218006186	substrate binding site [chemical binding]; other site
526218006187	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
526218006188	Acyltransferase family; Region: Acyl_transf_3; pfam01757
526218006189	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
526218006190	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
526218006191	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
526218006192	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
526218006193	active site
526218006194	Zn binding site [ion binding]; other site
526218006195	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526218006196	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
526218006197	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526218006198	Coenzyme A binding pocket [chemical binding]; other site
526218006199	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
526218006200	catalytic motif [active]
526218006201	Zn binding site [ion binding]; other site
526218006202	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
526218006203	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
526218006204	putative dimer interface [polypeptide binding]; other site
526218006205	putative anticodon binding site; other site
526218006206	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
526218006207	homodimer interface [polypeptide binding]; other site
526218006208	motif 1; other site
526218006209	motif 2; other site
526218006210	active site
526218006211	motif 3; other site
526218006212	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
526218006213	hypothetical protein; Provisional; Region: PRK02947
526218006214	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
526218006215	putative active site [active]
526218006216	Creatinine amidohydrolase; Region: Creatininase; pfam02633
526218006217	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
526218006218	active site
526218006219	substrate binding pocket [chemical binding]; other site
526218006220	homodimer interaction site [polypeptide binding]; other site
526218006221	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
526218006222	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
526218006223	active site
526218006224	P-loop; other site
526218006225	phosphorylation site [posttranslational modification]
526218006226	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218006227	active site
526218006228	phosphorylation site [posttranslational modification]
526218006229	Initiator Replication protein; Region: Rep_3; pfam01051
526218006230	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
526218006231	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
526218006232	ring oligomerisation interface [polypeptide binding]; other site
526218006233	ATP/Mg binding site [chemical binding]; other site
526218006234	stacking interactions; other site
526218006235	hinge regions; other site
526218006236	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
526218006237	oligomerisation interface [polypeptide binding]; other site
526218006238	mobile loop; other site
526218006239	roof hairpin; other site
526218006240	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
526218006241	SUKH-3 immunity protein; Region: SUKH-3; pfam14433
526218006242	Domain of unknown function (DUF4280); Region: DUF4280; pfam14107
526218006243	YwqJ-like deaminase; Region: YwqJ-deaminase; pfam14431
526218006244	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
526218006245	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
526218006246	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
526218006247	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817
526218006248	Baseplate J-like protein; Region: Baseplate_J; cl01294
526218006249	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
526218006250	Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876
526218006251	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526218006252	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
526218006253	DNA binding residues [nucleotide binding]
526218006254	DKNYY family; Region: DKNYY; pfam13644
526218006255	AAA domain; Region: AAA_25; pfam13481
526218006256	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
526218006257	Walker A motif; other site
526218006258	ATP binding site [chemical binding]; other site
526218006259	Walker B motif; other site
526218006260	Helix-turn-helix domain; Region: HTH_36; pfam13730
526218006261	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
526218006262	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
526218006263	dimer interface [polypeptide binding]; other site
526218006264	active site
526218006265	metal binding site [ion binding]; metal-binding site
526218006266	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
526218006267	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
526218006268	active site
526218006269	DNA binding site [nucleotide binding]
526218006270	Int/Topo IB signature motif; other site
526218006271	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
526218006272	Flavoprotein; Region: Flavoprotein; pfam02441
526218006273	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
526218006274	Protein of unknown function (DUF997); Region: DUF997; pfam06196
526218006275	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
526218006276	Na binding site [ion binding]; other site
526218006277	Protein of unknown function (DUF1439); Region: DUF1439; cl06345
526218006278	AzlC protein; Region: AzlC; cl00570
526218006279	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
526218006280	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
526218006281	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
526218006282	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
526218006283	catalytic core [active]
526218006284	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
526218006285	beta-galactosidase; Region: BGL; TIGR03356
526218006286	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
526218006287	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
526218006288	active site turn [active]
526218006289	phosphorylation site [posttranslational modification]
526218006290	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
526218006291	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
526218006292	HPr interaction site; other site
526218006293	glycerol kinase (GK) interaction site [polypeptide binding]; other site
526218006294	active site
526218006295	phosphorylation site [posttranslational modification]
526218006296	CAT RNA binding domain; Region: CAT_RBD; smart01061
526218006297	transcriptional antiterminator BglG; Provisional; Region: PRK09772
526218006298	PRD domain; Region: PRD; pfam00874
526218006299	PRD domain; Region: PRD; pfam00874
526218006300	DKNYY family; Region: DKNYY; pfam13644
526218006301	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526218006302	DKNYY family; Region: DKNYY; pfam13644
526218006303	DKNYY family; Region: DKNYY; pfam13644
526218006304	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
526218006305	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
526218006306	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
526218006307	metal-binding site [ion binding]
526218006308	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526218006309	dimerization interface [polypeptide binding]; other site
526218006310	putative DNA binding site [nucleotide binding]; other site
526218006311	putative Zn2+ binding site [ion binding]; other site
526218006312	Protein of unknown function (DUF554); Region: DUF554; pfam04474
526218006313	Protein of unknown function (DUF541); Region: SIMPL; cl01077
526218006314	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526218006315	dimerization interface [polypeptide binding]; other site
526218006316	putative DNA binding site [nucleotide binding]; other site
526218006317	putative Zn2+ binding site [ion binding]; other site
526218006318	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
526218006319	Predicted permeases [General function prediction only]; Region: COG0701
526218006320	Phosphotransferase enzyme family; Region: APH; pfam01636
526218006321	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
526218006322	substrate binding site [chemical binding]; other site
526218006323	magnesium transport protein MgtC; Provisional; Region: PRK15385
526218006324	MgtC family; Region: MgtC; pfam02308
526218006325	Domain of unknown function (DUF3784); Region: DUF3784; pfam12650
526218006326	magnesium-transporting ATPase; Provisional; Region: PRK15122
526218006327	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
526218006328	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
526218006329	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
526218006330	Soluble P-type ATPase [General function prediction only]; Region: COG4087
526218006331	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
526218006332	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
526218006333	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
526218006334	DNA binding residues [nucleotide binding]
526218006335	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
526218006336	Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206
526218006337	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
526218006338	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
526218006339	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526218006340	non-specific DNA binding site [nucleotide binding]; other site
526218006341	salt bridge; other site
526218006342	sequence-specific DNA binding site [nucleotide binding]; other site
526218006343	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
526218006344	AAA domain; Region: AAA_22; pfam13401
526218006345	HNH endonuclease; Region: HNH; pfam01844
526218006346	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526218006347	Walker A/P-loop; other site
526218006348	ATP binding site [chemical binding]; other site
526218006349	AAA domain; Region: AAA_21; pfam13304
526218006350	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
526218006351	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
526218006352	active site
526218006353	ATP binding site [chemical binding]; other site
526218006354	substrate binding site [chemical binding]; other site
526218006355	activation loop (A-loop); other site
526218006356	Restriction endonuclease; Region: Mrr_cat; pfam04471
526218006357	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
526218006358	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
526218006359	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
526218006360	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
526218006361	DKNYY family; Region: DKNYY; pfam13644
526218006362	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
526218006363	DHH family; Region: DHH; pfam01368
526218006364	Uncharacterized conserved protein [Function unknown]; Region: COG1284
526218006365	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
526218006366	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
526218006367	Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679
526218006368	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
526218006369	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
526218006370	Hpr binding site; other site
526218006371	active site
526218006372	homohexamer subunit interaction site [polypeptide binding]; other site
526218006373	Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679
526218006374	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
526218006375	Hpr binding site; other site
526218006376	active site
526218006377	homohexamer subunit interaction site [polypeptide binding]; other site
526218006378	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
526218006379	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
526218006380	acid-resistance membrane protein; Provisional; Region: PRK10209
526218006381	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
526218006382	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
526218006383	Isochorismatase family; Region: Isochorismatase; pfam00857
526218006384	catalytic triad [active]
526218006385	metal binding site [ion binding]; metal-binding site
526218006386	conserved cis-peptide bond; other site
526218006387	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
526218006388	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
526218006389	FtsH Extracellular; Region: FtsH_ext; pfam06480
526218006390	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
526218006391	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526218006392	Walker A motif; other site
526218006393	ATP binding site [chemical binding]; other site
526218006394	Walker B motif; other site
526218006395	arginine finger; other site
526218006396	Peptidase family M41; Region: Peptidase_M41; pfam01434
526218006397	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
526218006398	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
526218006399	Ligand Binding Site [chemical binding]; other site
526218006400	Stage II sporulation protein; Region: SpoIID; pfam08486
526218006401	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
526218006402	YceG-like family; Region: YceG; pfam02618
526218006403	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
526218006404	dimerization interface [polypeptide binding]; other site
526218006405	Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040
526218006406	Predicted transcriptional regulators [Transcription]; Region: COG1695
526218006407	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
526218006408	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
526218006409	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
526218006410	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
526218006411	SCP-2 sterol transfer family; Region: SCP2; pfam02036
526218006412	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
526218006413	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
526218006414	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
526218006415	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
526218006416	putative active site [active]
526218006417	putative metal binding site [ion binding]; other site
526218006418	DKNYY family; Region: DKNYY; pfam13644
526218006419	Protein of unknown function (DUF4241); Region: DUF4241; pfam14025
526218006420	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
526218006421	Protein of unknown function (DUF2185); Region: DUF2185; cl02019
526218006422	Autotransporter beta-domain; Region: Autotransporter; smart00869
526218006423	HlyD family secretion protein; Region: HlyD_2; pfam12700
526218006424	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
526218006425	HlyD family secretion protein; Region: HlyD_3; pfam13437
526218006426	multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459
526218006427	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
526218006428	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
526218006429	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
526218006430	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
526218006431	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
526218006432	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
526218006433	Mechanosensitive ion channel; Region: MS_channel; pfam00924
526218006434	GTP-binding protein YchF; Reviewed; Region: PRK09601
526218006435	YchF GTPase; Region: YchF; cd01900
526218006436	G1 box; other site
526218006437	GTP/Mg2+ binding site [chemical binding]; other site
526218006438	Switch I region; other site
526218006439	G2 box; other site
526218006440	Switch II region; other site
526218006441	G3 box; other site
526218006442	G4 box; other site
526218006443	G5 box; other site
526218006444	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
526218006445	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_2; cd10034
526218006446	putative uracil binding site [chemical binding]; other site
526218006447	putative active site [active]
526218006448	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
526218006449	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
526218006450	zinc binding site [ion binding]; other site
526218006451	putative ligand binding site [chemical binding]; other site
526218006452	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
526218006453	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526218006454	NAD(P) binding site [chemical binding]; other site
526218006455	active site
526218006456	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526218006457	Putative serine esterase (DUF676); Region: DUF676; pfam05057
526218006458	TM2 domain; Region: TM2; pfam05154
526218006459	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
526218006460	Protein of unknown function (DUF464); Region: DUF464; pfam04327
526218006461	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
526218006462	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
526218006463	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
526218006464	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
526218006465	active site
526218006466	catalytic site [active]
526218006467	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
526218006468	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
526218006469	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
526218006470	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218006471	binding surface
526218006472	TPR motif; other site
526218006473	Tetratricopeptide repeat; Region: TPR_12; pfam13424
526218006474	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218006475	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
526218006476	active site 1 [active]
526218006477	dimer interface [polypeptide binding]; other site
526218006478	hexamer interface [polypeptide binding]; other site
526218006479	active site 2 [active]
526218006480	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
526218006481	Transcriptional regulator [Transcription]; Region: LysR; COG0583
526218006482	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
526218006483	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
526218006484	dimerization interface [polypeptide binding]; other site
526218006485	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
526218006486	active site
526218006487	Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044
526218006488	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
526218006489	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
526218006490	active site
526218006491	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
526218006492	active site
526218006493	dimer interface [polypeptide binding]; other site
526218006494	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
526218006495	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
526218006496	heterodimer interface [polypeptide binding]; other site
526218006497	active site
526218006498	FMN binding site [chemical binding]; other site
526218006499	homodimer interface [polypeptide binding]; other site
526218006500	substrate binding site [chemical binding]; other site
526218006501	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
526218006502	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
526218006503	FAD binding pocket [chemical binding]; other site
526218006504	FAD binding motif [chemical binding]; other site
526218006505	phosphate binding motif [ion binding]; other site
526218006506	beta-alpha-beta structure motif; other site
526218006507	NAD binding pocket [chemical binding]; other site
526218006508	Iron coordination center [ion binding]; other site
526218006509	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
526218006510	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
526218006511	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
526218006512	Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540
526218006513	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
526218006514	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
526218006515	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
526218006516	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
526218006517	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
526218006518	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
526218006519	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
526218006520	ATP-grasp domain; Region: ATP-grasp_4; cl17255
526218006521	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
526218006522	IMP binding site; other site
526218006523	dimer interface [polypeptide binding]; other site
526218006524	interdomain contacts; other site
526218006525	partial ornithine binding site; other site
526218006526	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
526218006527	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
526218006528	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
526218006529	catalytic site [active]
526218006530	subunit interface [polypeptide binding]; other site
526218006531	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
526218006532	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
526218006533	active site
526218006534	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
526218006535	active site
526218006536	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
526218006537	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
526218006538	tetramer (dimer of dimers) interface [polypeptide binding]; other site
526218006539	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
526218006540	NAD binding site [chemical binding]; other site
526218006541	dimer interface [polypeptide binding]; other site
526218006542	substrate binding site [chemical binding]; other site
526218006543	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526218006544	S-adenosylmethionine binding site [chemical binding]; other site
526218006545	3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519
526218006546	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
526218006547	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
526218006548	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
526218006549	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
526218006550	catalytic loop [active]
526218006551	iron binding site [ion binding]; other site
526218006552	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
526218006553	xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971
526218006554	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
526218006555	xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970
526218006556	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
526218006557	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
526218006558	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
526218006559	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526218006560	motif II; other site
526218006561	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
526218006562	hypothetical protein; Provisional; Region: PRK10481
526218006563	Protein of unknown function (DUF1177); Region: DUF1177; pfam06675
526218006564	Protein of unknown function (DUF917); Region: DUF917; pfam06032
526218006565	OPT oligopeptide transporter protein; Region: OPT; cl14607
526218006566	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
526218006567	IHF - DNA interface [nucleotide binding]; other site
526218006568	IHF dimer interface [polypeptide binding]; other site
526218006569	Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283
526218006570	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
526218006571	CMP-binding site; other site
526218006572	The sites determining sugar specificity; other site
526218006573	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
526218006574	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526218006575	S-adenosylmethionine binding site [chemical binding]; other site
526218006576	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
526218006577	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
526218006578	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
526218006579	putative active site [active]
526218006580	metal binding site [ion binding]; metal-binding site
526218006581	homodimer binding site [polypeptide binding]; other site
526218006582	phosphodiesterase; Provisional; Region: PRK12704
526218006583	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
526218006584	Zn2+ binding site [ion binding]; other site
526218006585	Mg2+ binding site [ion binding]; other site
526218006586	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
526218006587	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
526218006588	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
526218006589	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
526218006590	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580
526218006591	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
526218006592	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
526218006593	homoserine kinase; Provisional; Region: PRK01212
526218006594	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
526218006595	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
526218006596	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
526218006597	ligand binding site [chemical binding]; other site
526218006598	NAD binding site [chemical binding]; other site
526218006599	dimerization interface [polypeptide binding]; other site
526218006600	catalytic site [active]
526218006601	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
526218006602	putative L-serine binding site [chemical binding]; other site
526218006603	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
526218006604	NlpC/P60 family; Region: NLPC_P60; pfam00877
526218006605	Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848
526218006606	catalytic triad [active]
526218006607	putative active site [active]
526218006608	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
526218006609	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218006610	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
526218006611	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
526218006612	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
526218006613	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
526218006614	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
526218006615	active site
526218006616	DNA binding site [nucleotide binding]
526218006617	Int/Topo IB signature motif; other site
526218006618	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
526218006619	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526218006620	Walker A/P-loop; other site
526218006621	ATP binding site [chemical binding]; other site
526218006622	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
526218006623	ABC transporter signature motif; other site
526218006624	Walker B; other site
526218006625	D-loop; other site
526218006626	H-loop/switch region; other site
526218006627	ATP-NAD kinase; Region: NAD_kinase; pfam01513
526218006628	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
526218006629	Peptidase family M23; Region: Peptidase_M23; pfam01551
526218006630	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
526218006631	FtsX-like permease family; Region: FtsX; pfam02687
526218006632	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
526218006633	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526218006634	Walker A/P-loop; other site
526218006635	ATP binding site [chemical binding]; other site
526218006636	Q-loop/lid; other site
526218006637	ABC transporter signature motif; other site
526218006638	Walker B; other site
526218006639	D-loop; other site
526218006640	H-loop/switch region; other site
526218006641	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
526218006642	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
526218006643	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526218006644	Eukaryotic protein of unknown function (DUF829); Region: DUF829; pfam05705
526218006645	hypothetical protein; Provisional; Region: PRK13670
526218006646	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
526218006647	OPT oligopeptide transporter protein; Region: OPT; cl14607
526218006648	oligopeptide transporter, OPT superfamily; Region: OPT_sfam; TIGR00728
526218006649	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
526218006650	nucleotide binding site [chemical binding]; other site
526218006651	Type III pantothenate kinase; Region: Pan_kinase; cl17198
526218006652	Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; pfam10020
526218006653	Autotransporter beta-domain; Region: Autotransporter; smart00869
526218006654	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
526218006655	Pyruvate formate lyase 1; Region: PFL1; cd01678
526218006656	coenzyme A binding site [chemical binding]; other site
526218006657	active site
526218006658	catalytic residues [active]
526218006659	glycine loop; other site
526218006660	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
526218006661	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526218006662	FeS/SAM binding site; other site
526218006663	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
526218006664	Transposase; Region: DEDD_Tnp_IS110; pfam01548
526218006665	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
526218006666	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
526218006667	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
526218006668	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
526218006669	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
526218006670	23S rRNA interface [nucleotide binding]; other site
526218006671	L3 interface [polypeptide binding]; other site
526218006672	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
526218006673	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
526218006674	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
526218006675	active site
526218006676	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
526218006677	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
526218006678	trimer interface [polypeptide binding]; other site
526218006679	active site
526218006680	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
526218006681	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
526218006682	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
526218006683	Predicted permeases [General function prediction only]; Region: COG0795
526218006684	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
526218006685	Predicted permeases [General function prediction only]; Region: COG0795
526218006686	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
526218006687	Colicin V production protein; Region: Colicin_V; pfam02674
526218006688	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
526218006689	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
526218006690	active site
526218006691	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
526218006692	dimer interface [polypeptide binding]; other site
526218006693	substrate binding site [chemical binding]; other site
526218006694	catalytic residues [active]
526218006695	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
526218006696	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
526218006697	Protein export membrane protein; Region: SecD_SecF; pfam02355
526218006698	protein-export membrane protein SecD; Region: secD; TIGR01129
526218006699	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
526218006700	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
526218006701	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
526218006702	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
526218006703	motif 1; other site
526218006704	active site
526218006705	motif 2; other site
526218006706	motif 3; other site
526218006707	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
526218006708	DHHA1 domain; Region: DHHA1; pfam02272
526218006709	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
526218006710	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
526218006711	Walker A/P-loop; other site
526218006712	ATP binding site [chemical binding]; other site
526218006713	Q-loop/lid; other site
526218006714	ABC transporter signature motif; other site
526218006715	Walker B; other site
526218006716	D-loop; other site
526218006717	H-loop/switch region; other site
526218006718	OstA-like protein; Region: OstA; cl00844
526218006719	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
526218006720	MutS domain I; Region: MutS_I; pfam01624
526218006721	MutS domain II; Region: MutS_II; pfam05188
526218006722	MutS domain III; Region: MutS_III; pfam05192
526218006723	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
526218006724	Walker A/P-loop; other site
526218006725	ATP binding site [chemical binding]; other site
526218006726	Q-loop/lid; other site
526218006727	ABC transporter signature motif; other site
526218006728	Walker B; other site
526218006729	D-loop; other site
526218006730	H-loop/switch region; other site
526218006731	trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656
526218006732	NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242
526218006733	Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241
526218006734	Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055
526218006735	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526218006736	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
526218006737	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
526218006738	HflX GTPase family; Region: HflX; cd01878
526218006739	G1 box; other site
526218006740	GTP/Mg2+ binding site [chemical binding]; other site
526218006741	Switch I region; other site
526218006742	G2 box; other site
526218006743	G3 box; other site
526218006744	Switch II region; other site
526218006745	G4 box; other site
526218006746	G5 box; other site
526218006747	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218006748	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
526218006749	intersubunit interface [polypeptide binding]; other site
526218006750	active site
526218006751	zinc binding site [ion binding]; other site
526218006752	Na+ binding site [ion binding]; other site
526218006753	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
526218006754	intersubunit interface [polypeptide binding]; other site
526218006755	active site
526218006756	zinc binding site [ion binding]; other site
526218006757	Na+ binding site [ion binding]; other site
526218006758	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
526218006759	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
526218006760	active site
526218006761	P-loop; other site
526218006762	phosphorylation site [posttranslational modification]
526218006763	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218006764	active site
526218006765	phosphorylation site [posttranslational modification]
526218006766	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
526218006767	HTH domain; Region: HTH_11; pfam08279
526218006768	Mga helix-turn-helix domain; Region: Mga; pfam05043
526218006769	PRD domain; Region: PRD; pfam00874
526218006770	PRD domain; Region: PRD; pfam00874
526218006771	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
526218006772	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
526218006773	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
526218006774	active site
526218006775	Uncharacterized conserved protein [Function unknown]; Region: COG1359
526218006776	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
526218006777	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526218006778	DNA-binding site [nucleotide binding]; DNA binding site
526218006779	UTRA domain; Region: UTRA; pfam07702
526218006780	putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815
526218006781	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
526218006782	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
526218006783	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
526218006784	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
526218006785	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
526218006786	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
526218006787	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
526218006788	FMN binding site [chemical binding]; other site
526218006789	active site
526218006790	catalytic residues [active]
526218006791	substrate binding site [chemical binding]; other site
526218006792	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
526218006793	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
526218006794	metal binding site [ion binding]; metal-binding site
526218006795	dimer interface [polypeptide binding]; other site
526218006796	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
526218006797	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
526218006798	dimer interface [polypeptide binding]; other site
526218006799	putative radical transfer pathway; other site
526218006800	diiron center [ion binding]; other site
526218006801	tyrosyl radical; other site
526218006802	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632
526218006803	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
526218006804	Class I ribonucleotide reductase; Region: RNR_I; cd01679
526218006805	active site
526218006806	dimer interface [polypeptide binding]; other site
526218006807	catalytic residues [active]
526218006808	effector binding site; other site
526218006809	R2 peptide binding site; other site
526218006810	NrdI Flavodoxin like; Region: Flavodoxin_NdrI; pfam07972
526218006811	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
526218006812	catalytic residues [active]
526218006813	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494
526218006814	putative outer membrane lipoprotein; Provisional; Region: PRK10510
526218006815	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
526218006816	ligand binding site [chemical binding]; other site
526218006817	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526218006818	Coenzyme A binding pocket [chemical binding]; other site
526218006819	signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705
526218006820	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
526218006821	active site
526218006822	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
526218006823	tandem repeat interface [polypeptide binding]; other site
526218006824	oligomer interface [polypeptide binding]; other site
526218006825	active site residues [active]
526218006826	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
526218006827	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526218006828	Response regulator receiver domain; Region: Response_reg; pfam00072
526218006829	active site
526218006830	phosphorylation site [posttranslational modification]
526218006831	intermolecular recognition site; other site
526218006832	dimerization interface [polypeptide binding]; other site
526218006833	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526218006834	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
526218006835	active site
526218006836	motif I; other site
526218006837	motif II; other site
526218006838	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526218006839	S-adenosylmethionine binding site [chemical binding]; other site
526218006840	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
526218006841	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
526218006842	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
526218006843	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
526218006844	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
526218006845	dimerization interface [polypeptide binding]; other site
526218006846	active site
526218006847	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
526218006848	Lumazine binding domain; Region: Lum_binding; pfam00677
526218006849	Lumazine binding domain; Region: Lum_binding; pfam00677
526218006850	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
526218006851	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
526218006852	catalytic motif [active]
526218006853	Zn binding site [ion binding]; other site
526218006854	RibD C-terminal domain; Region: RibD_C; cl17279
526218006855	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
526218006856	homopentamer interface [polypeptide binding]; other site
526218006857	active site
526218006858	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
526218006859	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
526218006860	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
526218006861	dimer interface [polypeptide binding]; other site
526218006862	active site
526218006863	Transcriptional regulator [Transcription]; Region: LysR; COG0583
526218006864	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
526218006865	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
526218006866	dimerization interface [polypeptide binding]; other site
526218006867	Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908
526218006868	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
526218006869	pyrroline-5-carboxylate reductase; Region: PLN02688
526218006870	TSCPD domain; Region: TSCPD; cl14834
526218006871	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
526218006872	phosphate binding site [ion binding]; other site
526218006873	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
526218006874	Transcriptional regulators [Transcription]; Region: PurR; COG1609
526218006875	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
526218006876	DNA binding site [nucleotide binding]
526218006877	domain linker motif; other site
526218006878	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
526218006879	ligand binding site [chemical binding]; other site
526218006880	dimerization interface [polypeptide binding]; other site
526218006881	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
526218006882	DKNYY family; Region: DKNYY; pfam13644
526218006883	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
526218006884	NADH(P)-binding; Region: NAD_binding_10; pfam13460
526218006885	NAD binding site [chemical binding]; other site
526218006886	substrate binding site [chemical binding]; other site
526218006887	putative active site [active]
526218006888	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
526218006889	dinuclear metal binding motif [ion binding]; other site
526218006890	CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431
526218006891	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
526218006892	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
526218006893	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
526218006894	putative catalytic cysteine [active]
526218006895	gamma-glutamyl kinase; Provisional; Region: PRK05429
526218006896	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
526218006897	nucleotide binding site [chemical binding]; other site
526218006898	homotetrameric interface [polypeptide binding]; other site
526218006899	putative phosphate binding site [ion binding]; other site
526218006900	putative allosteric binding site; other site
526218006901	PUA domain; Region: PUA; pfam01472
526218006902	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
526218006903	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
526218006904	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
526218006905	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
526218006906	active site
526218006907	Na/Ca binding site [ion binding]; other site
526218006908	catalytic site [active]
526218006909	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
526218006910	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
526218006911	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
526218006912	Walker A/P-loop; other site
526218006913	ATP binding site [chemical binding]; other site
526218006914	Q-loop/lid; other site
526218006915	ABC transporter signature motif; other site
526218006916	Walker B; other site
526218006917	D-loop; other site
526218006918	H-loop/switch region; other site
526218006919	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
526218006920	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
526218006921	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526218006922	Walker A/P-loop; other site
526218006923	ATP binding site [chemical binding]; other site
526218006924	Q-loop/lid; other site
526218006925	ABC transporter signature motif; other site
526218006926	Walker B; other site
526218006927	D-loop; other site
526218006928	H-loop/switch region; other site
526218006929	4-alpha-glucanotransferase; Provisional; Region: PRK14508
526218006930	hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980
526218006931	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
526218006932	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
526218006933	active site
526218006934	metal binding site [ion binding]; metal-binding site
526218006935	Baseplate J-like protein; Region: Baseplate_J; cl01294
526218006936	Mu-like prophage protein [General function prediction only]; Region: COG3941
526218006937	Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979
526218006938	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
526218006939	phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555
526218006940	Protein of unknown function (DUF1073); Region: DUF1073; pfam06381
526218006941	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410
526218006942	Terminase-like family; Region: Terminase_6; pfam03237
526218006943	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
526218006944	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
526218006945	Protein of unknown function (DUF968); Region: DUF968; pfam06147
526218006946	YopX protein; Region: YopX; cl09859
526218006947	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
526218006948	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
526218006949	cofactor binding site; other site
526218006950	DNA binding site [nucleotide binding]
526218006951	substrate interaction site [chemical binding]; other site
526218006952	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
526218006953	Recombination protein U; Region: RecU; cl01314
526218006954	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
526218006955	metal binding site [ion binding]; metal-binding site
526218006956	Helix-turn-helix domain; Region: HTH_36; pfam13730
526218006957	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
526218006958	non-specific DNA binding site [nucleotide binding]; other site
526218006959	salt bridge; other site
526218006960	sequence-specific DNA binding site [nucleotide binding]; other site
526218006961	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526218006962	non-specific DNA binding site [nucleotide binding]; other site
526218006963	salt bridge; other site
526218006964	sequence-specific DNA binding site [nucleotide binding]; other site
526218006965	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
526218006966	Catalytic site [active]
526218006967	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713
526218006968	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
526218006969	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526218006970	non-specific DNA binding site [nucleotide binding]; other site
526218006971	salt bridge; other site
526218006972	sequence-specific DNA binding site [nucleotide binding]; other site
526218006973	P22_AR N-terminal domain; Region: P22_AR_N; pfam10547
526218006974	ERF superfamily; Region: ERF; pfam04404
526218006975	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
526218006976	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
526218006977	dimer interface [polypeptide binding]; other site
526218006978	ssDNA binding site [nucleotide binding]; other site
526218006979	tetramer (dimer of dimers) interface [polypeptide binding]; other site
526218006980	YopX protein; Region: YopX; pfam09643
526218006981	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
526218006982	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
526218006983	catalytic residues [active]
526218006984	catalytic nucleophile [active]
526218006985	Recombinase; Region: Recombinase; pfam07508
526218006986	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526218006987	Coenzyme A binding pocket [chemical binding]; other site
526218006988	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
526218006989	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
526218006990	DNA binding residues [nucleotide binding]
526218006991	drug binding residues [chemical binding]; other site
526218006992	dimer interface [polypeptide binding]; other site
526218006993	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
526218006994	putative RNA ligase; Region: PHA02142
526218006995	RNA ligase; Region: RNA_ligase; pfam09414
526218006996	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
526218006997	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
526218006998	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
526218006999	putative acyl-acceptor binding pocket; other site
526218007000	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
526218007001	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526218007002	non-specific DNA binding site [nucleotide binding]; other site
526218007003	salt bridge; other site
526218007004	sequence-specific DNA binding site [nucleotide binding]; other site
526218007005	Predicted transcriptional regulator [Transcription]; Region: COG2932
526218007006	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
526218007007	Catalytic site [active]
526218007008	MarR family; Region: MarR_2; cl17246
526218007009	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
526218007010	amidase catalytic site [active]
526218007011	Zn binding residues [ion binding]; other site
526218007012	substrate binding site [chemical binding]; other site
526218007013	Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812
526218007014	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
526218007015	Baseplate J-like protein; Region: Baseplate_J; cl01294
526218007016	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
526218007017	bacteriocin maturation radical SAM protein 1; Region: rSAM_ocin_1; TIGR03975
526218007018	DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003
526218007019	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
526218007020	MPN+ (JAMM) motif; other site
526218007021	Zinc-binding site [ion binding]; other site
526218007022	PSP1 C-terminal conserved region; Region: PSP1; pfam04468
526218007023	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
526218007024	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
526218007025	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526218007026	S-adenosylmethionine binding site [chemical binding]; other site
526218007027	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
526218007028	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526218007029	Coenzyme A binding pocket [chemical binding]; other site
526218007030	Uncharacterized conserved protein [Function unknown]; Region: COG0327
526218007031	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
526218007032	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
526218007033	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526218007034	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
526218007035	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
526218007036	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
526218007037	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526218007038	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
526218007039	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
526218007040	DNA binding residues [nucleotide binding]
526218007041	DNA primase, catalytic core; Region: dnaG; TIGR01391
526218007042	CHC2 zinc finger; Region: zf-CHC2; cl17510
526218007043	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
526218007044	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
526218007045	active site
526218007046	metal binding site [ion binding]; metal-binding site
526218007047	interdomain interaction site; other site
526218007048	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
526218007049	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
526218007050	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
526218007051	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
526218007052	catalytic site [active]
526218007053	G-X2-G-X-G-K; other site
526218007054	Domain of unknown function (DUF370); Region: DUF370; cl00898
526218007055	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
526218007056	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
526218007057	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
526218007058	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
526218007059	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
526218007060	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
526218007061	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
526218007062	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
526218007063	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
526218007064	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
526218007065	DNA binding site [nucleotide binding]
526218007066	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
526218007067	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
526218007068	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
526218007069	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
526218007070	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
526218007071	RPB1 interaction site [polypeptide binding]; other site
526218007072	RPB10 interaction site [polypeptide binding]; other site
526218007073	RPB11 interaction site [polypeptide binding]; other site
526218007074	RPB3 interaction site [polypeptide binding]; other site
526218007075	RPB12 interaction site [polypeptide binding]; other site
526218007076	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
526218007077	peripheral dimer interface [polypeptide binding]; other site
526218007078	core dimer interface [polypeptide binding]; other site
526218007079	L10 interface [polypeptide binding]; other site
526218007080	L11 interface [polypeptide binding]; other site
526218007081	putative EF-Tu interaction site [polypeptide binding]; other site
526218007082	putative EF-G interaction site [polypeptide binding]; other site
526218007083	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
526218007084	23S rRNA interface [nucleotide binding]; other site
526218007085	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
526218007086	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
526218007087	mRNA/rRNA interface [nucleotide binding]; other site
526218007088	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
526218007089	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
526218007090	23S rRNA interface [nucleotide binding]; other site
526218007091	L7/L12 interface [polypeptide binding]; other site
526218007092	putative thiostrepton binding site; other site
526218007093	L25 interface [polypeptide binding]; other site
526218007094	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
526218007095	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
526218007096	putative homodimer interface [polypeptide binding]; other site
526218007097	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
526218007098	heterodimer interface [polypeptide binding]; other site
526218007099	homodimer interface [polypeptide binding]; other site
526218007100	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
526218007101	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
526218007102	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178
526218007103	putative ligand binding site [chemical binding]; other site
526218007104	putative NAD binding site [chemical binding]; other site
526218007105	catalytic site [active]
526218007106	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
526218007107	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
526218007108	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
526218007109	active site turn [active]
526218007110	phosphorylation site [posttranslational modification]
526218007111	Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803
526218007112	putative active site [active]
526218007113	YdjC motif; other site
526218007114	Mg binding site [ion binding]; other site
526218007115	putative homodimer interface [polypeptide binding]; other site
526218007116	CAT RNA binding domain; Region: CAT_RBD; smart01061
526218007117	PRD domain; Region: PRD; pfam00874
526218007118	PRD domain; Region: PRD; pfam00874
526218007119	DNA polymerase IV; Provisional; Region: PRK14133
526218007120	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
526218007121	active site
526218007122	DNA binding site [nucleotide binding]
526218007123	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
526218007124	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
526218007125	metal binding site [ion binding]; metal-binding site
526218007126	dimer interface [polypeptide binding]; other site
526218007127	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
526218007128	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
526218007129	putative active site [active]
526218007130	putative metal binding site [ion binding]; other site
526218007131	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
526218007132	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
526218007133	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
526218007134	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
526218007135	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
526218007136	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526218007137	homodimer interface [polypeptide binding]; other site
526218007138	catalytic residue [active]
526218007139	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
526218007140	active site
526218007141	dimerization interface [polypeptide binding]; other site
526218007142	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
526218007143	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
526218007144	putative acyl-acceptor binding pocket; other site
526218007145	RecX family; Region: RecX; cl00936
526218007146	recombinase A; Provisional; Region: recA; PRK09354
526218007147	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
526218007148	hexamer interface [polypeptide binding]; other site
526218007149	Walker A motif; other site
526218007150	ATP binding site [chemical binding]; other site
526218007151	Walker B motif; other site
526218007152	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
526218007153	TPR motif; other site
526218007154	binding surface
526218007155	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218007156	binding surface
526218007157	TPR motif; other site
526218007158	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218007159	TPR motif; other site
526218007160	binding surface
526218007161	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
526218007162	protein binding site [polypeptide binding]; other site
526218007163	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
526218007164	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
526218007165	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
526218007166	active site
526218007167	trimer interface [polypeptide binding]; other site
526218007168	substrate binding site [chemical binding]; other site
526218007169	CoA binding site [chemical binding]; other site
526218007170	dihydrodipicolinate reductase; Provisional; Region: PRK00048
526218007171	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
526218007172	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
526218007173	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
526218007174	Cysteine-rich small domain; Region: zf-like; cl00946
526218007175	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
526218007176	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526218007177	non-specific DNA binding site [nucleotide binding]; other site
526218007178	salt bridge; other site
526218007179	sequence-specific DNA binding site [nucleotide binding]; other site
526218007180	Domain of unknown function (DUF955); Region: DUF955; cl01076
526218007181	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
526218007182	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
526218007183	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
526218007184	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
526218007185	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
526218007186	dimer interface [polypeptide binding]; other site
526218007187	active site
526218007188	catalytic residue [active]
526218007189	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
526218007190	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
526218007191	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
526218007192	aspartate kinase; Reviewed; Region: PRK06635
526218007193	AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246
526218007194	putative catalytic residues [active]
526218007195	putative nucleotide binding site [chemical binding]; other site
526218007196	putative aspartate binding site [chemical binding]; other site
526218007197	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
526218007198	putative allosteric regulatory site; other site
526218007199	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
526218007200	diaminopimelate decarboxylase; Region: lysA; TIGR01048
526218007201	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
526218007202	active site
526218007203	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
526218007204	substrate binding site [chemical binding]; other site
526218007205	catalytic residues [active]
526218007206	dimer interface [polypeptide binding]; other site
526218007207	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
526218007208	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
526218007209	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
526218007210	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
526218007211	beta-galactosidase; Region: BGL; TIGR03356
526218007212	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
526218007213	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526218007214	DNA-binding site [nucleotide binding]; DNA binding site
526218007215	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
526218007216	Protein of unknown function (DUF419); Region: DUF419; pfam04237
526218007217	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
526218007218	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
526218007219	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
526218007220	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
526218007221	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526218007222	DNA-binding site [nucleotide binding]; DNA binding site
526218007223	UTRA domain; Region: UTRA; pfam07702
526218007224	Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560
526218007225	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
526218007226	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
526218007227	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
526218007228	active site
526218007229	phosphorylation site [posttranslational modification]
526218007230	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
526218007231	active pocket/dimerization site; other site
526218007232	active site
526218007233	phosphorylation site [posttranslational modification]
526218007234	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
526218007235	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
526218007236	glucose-6-phosphate isomerase; Provisional; Region: PRK04190
526218007237	Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560
526218007238	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
526218007239	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
526218007240	DNA-binding site [nucleotide binding]; DNA binding site
526218007241	RNA-binding motif; other site
526218007242	aspartate kinase; Reviewed; Region: PRK06635
526218007243	AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246
526218007244	putative catalytic residues [active]
526218007245	putative nucleotide binding site [chemical binding]; other site
526218007246	putative aspartate binding site [chemical binding]; other site
526218007247	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
526218007248	putative allosteric regulatory site; other site
526218007249	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
526218007250	putative allosteric regulatory residue; other site
526218007251	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
526218007252	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
526218007253	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
526218007254	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
526218007255	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
526218007256	ligand binding site [chemical binding]; other site
526218007257	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
526218007258	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
526218007259	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
526218007260	Isochorismatase family; Region: Isochorismatase; pfam00857
526218007261	catalytic triad [active]
526218007262	conserved cis-peptide bond; other site
526218007263	Predicted transcriptional regulators [Transcription]; Region: COG1733
526218007264	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
526218007265	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
526218007266	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
526218007267	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
526218007268	NAD binding site [chemical binding]; other site
526218007269	ligand binding site [chemical binding]; other site
526218007270	catalytic site [active]
526218007271	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
526218007272	active pocket/dimerization site; other site
526218007273	active site
526218007274	phosphorylation site [posttranslational modification]
526218007275	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
526218007276	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
526218007277	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
526218007278	active site
526218007279	phosphorylation site [posttranslational modification]
526218007280	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
526218007281	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
526218007282	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
526218007283	putative active site cavity [active]
526218007284	DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411
526218007285	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526218007286	DNA-binding site [nucleotide binding]; DNA binding site
526218007287	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
526218007288	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
526218007289	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526218007290	FeS/SAM binding site; other site
526218007291	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
526218007292	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
526218007293	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526218007294	Walker A/P-loop; other site
526218007295	ATP binding site [chemical binding]; other site
526218007296	Q-loop/lid; other site
526218007297	ABC transporter signature motif; other site
526218007298	Walker B; other site
526218007299	D-loop; other site
526218007300	H-loop/switch region; other site
526218007301	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526218007302	dimer interface [polypeptide binding]; other site
526218007303	conserved gate region; other site
526218007304	putative PBP binding loops; other site
526218007305	ABC-ATPase subunit interface; other site
526218007306	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
526218007307	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
526218007308	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
526218007309	nucleotide binding site [chemical binding]; other site
526218007310	substrate binding site [chemical binding]; other site
526218007311	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
526218007312	putative deacylase active site [active]
526218007313	Transcriptional regulator [Transcription]; Region: LysR; COG0583
526218007314	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
526218007315	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
526218007316	dimerization interface [polypeptide binding]; other site
526218007317	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
526218007318	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
526218007319	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
526218007320	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
526218007321	N- and C-terminal domain interface [polypeptide binding]; other site
526218007322	D-xylulose kinase; Region: XylB; TIGR01312
526218007323	active site
526218007324	MgATP binding site [chemical binding]; other site
526218007325	catalytic site [active]
526218007326	metal binding site [ion binding]; metal-binding site
526218007327	xylulose binding site [chemical binding]; other site
526218007328	homodimer interface [polypeptide binding]; other site
526218007329	xylose isomerase; Provisional; Region: PRK05474
526218007330	xylose isomerase; Region: xylose_isom_A; TIGR02630
526218007331	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
526218007332	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
526218007333	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
526218007334	TM-ABC transporter signature motif; other site
526218007335	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
526218007336	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
526218007337	Walker A/P-loop; other site
526218007338	ATP binding site [chemical binding]; other site
526218007339	Q-loop/lid; other site
526218007340	ABC transporter signature motif; other site
526218007341	Walker B; other site
526218007342	D-loop; other site
526218007343	H-loop/switch region; other site
526218007344	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
526218007345	D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355
526218007346	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
526218007347	putative ligand binding site [chemical binding]; other site
526218007348	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
526218007349	YheO-like PAS domain; Region: PAS_6; pfam08348
526218007350	HTH domain; Region: HTH_22; pfam13309
526218007351	D-allose transporter subunit; Provisional; Region: PRK09701
526218007352	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
526218007353	D-allose kinase; Provisional; Region: PRK09698
526218007354	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
526218007355	nucleotide binding site [chemical binding]; other site
526218007356	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
526218007357	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
526218007358	substrate binding site [chemical binding]; other site
526218007359	hexamer interface [polypeptide binding]; other site
526218007360	metal binding site [ion binding]; metal-binding site
526218007361	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
526218007362	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
526218007363	TM-ABC transporter signature motif; other site
526218007364	D-allose transporter ATP-binding protein; Provisional; Region: PRK09700
526218007365	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
526218007366	Walker A/P-loop; other site
526218007367	ATP binding site [chemical binding]; other site
526218007368	Q-loop/lid; other site
526218007369	ABC transporter signature motif; other site
526218007370	Walker B; other site
526218007371	D-loop; other site
526218007372	H-loop/switch region; other site
526218007373	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
526218007374	Transcriptional regulators [Transcription]; Region: PurR; COG1609
526218007375	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
526218007376	DNA binding site [nucleotide binding]
526218007377	domain linker motif; other site
526218007378	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
526218007379	dimerization interface [polypeptide binding]; other site
526218007380	ligand binding site [chemical binding]; other site
526218007381	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
526218007382	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
526218007383	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
526218007384	active site
526218007385	catalytic site [active]
526218007386	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
526218007387	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
526218007388	active site
526218007389	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; cl01381
526218007390	hypothetical protein; Reviewed; Region: PRK12497
526218007391	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
526218007392	RNA/DNA hybrid binding site [nucleotide binding]; other site
526218007393	active site
526218007394	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
526218007395	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
526218007396	DNA binding site [nucleotide binding]
526218007397	active site
526218007398	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
526218007399	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
526218007400	RNA binding surface [nucleotide binding]; other site
526218007401	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
526218007402	active site
526218007403	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
526218007404	active site
526218007405	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
526218007406	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526218007407	motif II; other site
526218007408	Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699
526218007409	von Willebrand factor type A domain; Region: VWA_2; pfam13519
526218007410	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218007411	binding surface
526218007412	Tetratricopeptide repeat; Region: TPR_16; pfam13432
526218007413	TPR motif; other site
526218007414	Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906
526218007415	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
526218007416	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
526218007417	dimer interface [polypeptide binding]; other site
526218007418	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526218007419	catalytic residue [active]
526218007420	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
526218007421	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
526218007422	putative active site [active]
526218007423	putative metal binding site [ion binding]; other site
526218007424	thymidine kinase; Provisional; Region: PRK04296
526218007425	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
526218007426	Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298
526218007427	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
526218007428	NAD binding site [chemical binding]; other site
526218007429	sugar binding site [chemical binding]; other site
526218007430	divalent metal binding site [ion binding]; other site
526218007431	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
526218007432	dimer interface [polypeptide binding]; other site
526218007433	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
526218007434	bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110
526218007435	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
526218007436	active site turn [active]
526218007437	phosphorylation site [posttranslational modification]
526218007438	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526218007439	putative DNA binding site [nucleotide binding]; other site
526218007440	dimerization interface [polypeptide binding]; other site
526218007441	putative Zn2+ binding site [ion binding]; other site
526218007442	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
526218007443	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
526218007444	tetramer interface [polypeptide binding]; other site
526218007445	active site
526218007446	Mg2+/Mn2+ binding site [ion binding]; other site
526218007447	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
526218007448	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
526218007449	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
526218007450	putative active site [active]
526218007451	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
526218007452	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
526218007453	nucleotide binding site [chemical binding]; other site
526218007454	CheW-like domain; Region: CheW; pfam01584
526218007455	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
526218007456	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
526218007457	dimer interface [polypeptide binding]; other site
526218007458	putative CheW interface [polypeptide binding]; other site
526218007459	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
526218007460	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
526218007461	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
526218007462	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
526218007463	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
526218007464	active site
526218007465	HIGH motif; other site
526218007466	dimer interface [polypeptide binding]; other site
526218007467	KMSKS motif; other site
526218007468	EVE domain; Region: EVE; cl00728
526218007469	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
526218007470	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
526218007471	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
526218007472	substrate binding pocket [chemical binding]; other site
526218007473	dimer interface [polypeptide binding]; other site
526218007474	inhibitor binding site; inhibition site
526218007475	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
526218007476	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
526218007477	B12 binding site [chemical binding]; other site
526218007478	cobalt ligand [ion binding]; other site
526218007479	Protein of unknown function (DUF975); Region: DUF975; cl10504
526218007480	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
526218007481	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
526218007482	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
526218007483	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
526218007484	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
526218007485	hinge; other site
526218007486	active site
526218007487	Protein of unknown function (DUF1694); Region: DUF1694; cl02318
526218007488	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
526218007489	UGMP family protein; Validated; Region: PRK09604
526218007490	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
526218007491	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
526218007492	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
526218007493	putative active site [active]
526218007494	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
526218007495	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
526218007496	putative active site [active]
526218007497	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
526218007498	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
526218007499	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
526218007500	serine/threonine protein kinase; Provisional; Region: PRK14879
526218007501	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
526218007502	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
526218007503	putative ADP-binding pocket [chemical binding]; other site
526218007504	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
526218007505	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
526218007506	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
526218007507	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
526218007508	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
526218007509	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526218007510	NAD(P) binding site [chemical binding]; other site
526218007511	active site
526218007512	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
526218007513	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
526218007514	putative ADP-binding pocket [chemical binding]; other site
526218007515	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
526218007516	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
526218007517	putative ADP-binding pocket [chemical binding]; other site
526218007518	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
526218007519	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
526218007520	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
526218007521	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
526218007522	putative ADP-binding pocket [chemical binding]; other site
526218007523	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
526218007524	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
526218007525	putative metal binding site; other site
526218007526	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
526218007527	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
526218007528	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
526218007529	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
526218007530	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
526218007531	putative ADP-binding pocket [chemical binding]; other site
526218007532	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
526218007533	Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075
526218007534	putative active site [active]
526218007535	Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969
526218007536	putative active site [active]
526218007537	putative metal binding site [ion binding]; other site
526218007538	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
526218007539	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
526218007540	trimer interface [polypeptide binding]; other site
526218007541	active site
526218007542	substrate binding site [chemical binding]; other site
526218007543	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
526218007544	CoA binding site [chemical binding]; other site
526218007545	Uncharacterized conserved protein (DUF2164); Region: DUF2164; cl02278
526218007546	Protein of unknown function (DUF4026); Region: DUF4026; pfam13218
526218007547	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779
526218007548	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
526218007549	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
526218007550	PA/protease or protease-like domain interface [polypeptide binding]; other site
526218007551	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
526218007552	Peptidase family M28; Region: Peptidase_M28; pfam04389
526218007553	metal binding site [ion binding]; metal-binding site
526218007554	putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304
526218007555	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
526218007556	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
526218007557	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204
526218007558	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
526218007559	dimer interface [polypeptide binding]; other site
526218007560	active site
526218007561	CoA binding pocket [chemical binding]; other site
526218007562	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
526218007563	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526218007564	NAD(P) binding site [chemical binding]; other site
526218007565	active site
526218007566	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
526218007567	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
526218007568	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
526218007569	active site
526218007570	Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506
526218007571	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
526218007572	classical (c) SDRs; Region: SDR_c; cd05233
526218007573	NAD(P) binding site [chemical binding]; other site
526218007574	active site
526218007575	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
526218007576	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
526218007577	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
526218007578	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526218007579	DNA-binding site [nucleotide binding]; DNA binding site
526218007580	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
526218007581	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
526218007582	active site
526218007583	catalytic triad [active]
526218007584	oxyanion hole [active]
526218007585	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
526218007586	beta-galactosidase; Region: BGL; TIGR03356
526218007587	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
526218007588	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
526218007589	polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075
526218007590	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
526218007591	active site
526218007592	metal binding site [ion binding]; metal-binding site
526218007593	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526218007594	S-adenosylmethionine binding site [chemical binding]; other site
526218007595	META domain; Region: META; pfam03724
526218007596	Helix-turn-helix domain; Region: HTH_18; pfam12833
526218007597	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526218007598	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
526218007599	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
526218007600	NodB motif; other site
526218007601	active site
526218007602	catalytic site [active]
526218007603	Zn binding site [ion binding]; other site
526218007604	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
526218007605	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
526218007606	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526218007607	Walker A/P-loop; other site
526218007608	ATP binding site [chemical binding]; other site
526218007609	Q-loop/lid; other site
526218007610	ABC transporter signature motif; other site
526218007611	Walker B; other site
526218007612	D-loop; other site
526218007613	H-loop/switch region; other site
526218007614	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
526218007615	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
526218007616	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
526218007617	Walker A/P-loop; other site
526218007618	ATP binding site [chemical binding]; other site
526218007619	Q-loop/lid; other site
526218007620	ABC transporter signature motif; other site
526218007621	Walker B; other site
526218007622	D-loop; other site
526218007623	H-loop/switch region; other site
526218007624	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
526218007625	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
526218007626	YcxB-like protein; Region: YcxB; pfam14317
526218007627	nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526
526218007628	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
526218007629	active site
526218007630	nucleotide binding site [chemical binding]; other site
526218007631	HIGH motif; other site
526218007632	KMSKS motif; other site
526218007633	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
526218007634	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
526218007635	RNA 2'-phosphotransferase; Reviewed; Region: PRK00819
526218007636	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
526218007637	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
526218007638	Domain of unknown function (DUF4291); Region: DUF4291; pfam14124
526218007639	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
526218007640	Domain of unknown function (DUF4424); Region: DUF4424; pfam14415
526218007641	YARHG domain; Region: YARHG; pfam13308
526218007642	YARHG domain; Region: YARHG; pfam13308
526218007643	P22_AR N-terminal domain; Region: P22_AR_N; pfam10547
526218007644	DKNYY family; Region: DKNYY; pfam13644
526218007645	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
526218007646	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526218007647	MarR family; Region: MarR; pfam01047
526218007648	MarR family; Region: MarR_2; cl17246
526218007649	Transcriptional regulators [Transcription]; Region: MarR; COG1846
526218007650	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
526218007651	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
526218007652	putative NAD(P) binding site [chemical binding]; other site
526218007653	catalytic Zn binding site [ion binding]; other site
526218007654	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
526218007655	intersubunit interface [polypeptide binding]; other site
526218007656	active site
526218007657	zinc binding site [ion binding]; other site
526218007658	Na+ binding site [ion binding]; other site
526218007659	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
526218007660	L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235
526218007661	putative NAD(P) binding site [chemical binding]; other site
526218007662	catalytic Zn binding site [ion binding]; other site
526218007663	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
526218007664	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
526218007665	nucleotide binding site [chemical binding]; other site
526218007666	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
526218007667	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
526218007668	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
526218007669	active site
526218007670	P-loop; other site
526218007671	phosphorylation site [posttranslational modification]
526218007672	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218007673	active site
526218007674	phosphorylation site [posttranslational modification]
526218007675	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
526218007676	PRD domain; Region: PRD; pfam00874
526218007677	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
526218007678	active site
526218007679	P-loop; other site
526218007680	phosphorylation site [posttranslational modification]
526218007681	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218007682	active site
526218007683	phosphorylation site [posttranslational modification]
526218007684	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
526218007685	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
526218007686	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
526218007687	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
526218007688	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
526218007689	Protein of unknown function (DUF1576); Region: DUF1576; pfam07613
526218007690	Protein of unknown function (DUF1576); Region: DUF1576; pfam07613
526218007691	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
526218007692	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
526218007693	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
526218007694	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
526218007695	Walker A/P-loop; other site
526218007696	ATP binding site [chemical binding]; other site
526218007697	Q-loop/lid; other site
526218007698	ABC transporter signature motif; other site
526218007699	Walker B; other site
526218007700	D-loop; other site
526218007701	H-loop/switch region; other site
526218007702	FtsX-like permease family; Region: FtsX; pfam02687
526218007703	FtsX-like permease family; Region: FtsX; pfam02687
526218007704	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
526218007705	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526218007706	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526218007707	Membrane protease subunit, stomatin/prohibitin family [Amino acid    transport and metabolism]; Region: COG4260
526218007708	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
526218007709	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
526218007710	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
526218007711	Double zinc ribbon; Region: DZR; pfam12773
526218007712	Repair protein; Region: Repair_PSII; pfam04536
526218007713	Transposase IS200 like; Region: Y1_Tnp; pfam01797
526218007714	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
526218007715	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
526218007716	putative active site [active]
526218007717	putative metal binding site [ion binding]; other site
526218007718	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
526218007719	PRD domain; Region: PRD; pfam00874
526218007720	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
526218007721	active site
526218007722	P-loop; other site
526218007723	phosphorylation site [posttranslational modification]
526218007724	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526218007725	MarR family; Region: MarR_2; pfam12802
526218007726	Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439
526218007727	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
526218007728	active site
526218007729	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
526218007730	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526218007731	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526218007732	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
526218007733	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
526218007734	DNA binding residues [nucleotide binding]
526218007735	dimer interface [polypeptide binding]; other site
526218007736	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
526218007737	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
526218007738	PRD domain; Region: PRD; pfam00874
526218007739	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
526218007740	active site
526218007741	P-loop; other site
526218007742	phosphorylation site [posttranslational modification]
526218007743	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
526218007744	active site
526218007745	phosphorylation site [posttranslational modification]
526218007746	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218007747	active site
526218007748	phosphorylation site [posttranslational modification]
526218007749	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
526218007750	active site
526218007751	P-loop; other site
526218007752	phosphorylation site [posttranslational modification]
526218007753	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
526218007754	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
526218007755	active site
526218007756	substrate binding pocket [chemical binding]; other site
526218007757	homodimer interaction site [polypeptide binding]; other site
526218007758	Creatinine amidohydrolase; Region: Creatininase; pfam02633
526218007759	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
526218007760	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
526218007761	active site
526218007762	intersubunit interface [polypeptide binding]; other site
526218007763	catalytic residue [active]
526218007764	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526218007765	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526218007766	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218007767	binding surface
526218007768	TPR motif; other site
526218007769	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
526218007770	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526218007771	Coenzyme A binding pocket [chemical binding]; other site
526218007772	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
526218007773	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
526218007774	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
526218007775	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
526218007776	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
526218007777	beta-galactosidase; Region: BGL; TIGR03356
526218007778	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
526218007779	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526218007780	DNA-binding site [nucleotide binding]; DNA binding site
526218007781	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
526218007782	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
526218007783	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526218007784	DNA-binding site [nucleotide binding]; DNA binding site
526218007785	UTRA domain; Region: UTRA; pfam07702
526218007786	sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171
526218007787	classical (c) SDRs; Region: SDR_c; cd05233
526218007788	NAD(P) binding site [chemical binding]; other site
526218007789	active site
526218007790	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
526218007791	active pocket/dimerization site; other site
526218007792	active site
526218007793	phosphorylation site [posttranslational modification]
526218007794	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
526218007795	active site
526218007796	phosphorylation site [posttranslational modification]
526218007797	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
526218007798	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
526218007799	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
526218007800	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
526218007801	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
526218007802	DAK2 domain; Region: Dak2; pfam02734
526218007803	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
526218007804	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
526218007805	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
526218007806	active site
526218007807	dimer interface [polypeptide binding]; other site
526218007808	magnesium binding site [ion binding]; other site
526218007809	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
526218007810	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
526218007811	tetramer interface [polypeptide binding]; other site
526218007812	active site
526218007813	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
526218007814	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
526218007815	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
526218007816	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
526218007817	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
526218007818	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
526218007819	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
526218007820	active site
526218007821	catalytic tetrad [active]
526218007822	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
526218007823	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
526218007824	substrate binding site [chemical binding]; other site
526218007825	ATP binding site [chemical binding]; other site
526218007826	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
526218007827	intersubunit interface [polypeptide binding]; other site
526218007828	active site
526218007829	zinc binding site [ion binding]; other site
526218007830	Na+ binding site [ion binding]; other site
526218007831	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
526218007832	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
526218007833	inhibitor binding site; inhibition site
526218007834	catalytic Zn binding site [ion binding]; other site
526218007835	structural Zn binding site [ion binding]; other site
526218007836	NADP binding site [chemical binding]; other site
526218007837	tetramer interface [polypeptide binding]; other site
526218007838	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526218007839	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
526218007840	putative substrate translocation pore; other site
526218007841	Vacuolar (H+)-ATPase G subunit; Region: V-ATPase_G; cl03922
526218007842	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526218007843	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
526218007844	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258
526218007845	putative NAD(P) binding site [chemical binding]; other site
526218007846	catalytic Zn binding site [ion binding]; other site
526218007847	structural Zn binding site [ion binding]; other site
526218007848	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
526218007849	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
526218007850	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
526218007851	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
526218007852	DNA binding residues [nucleotide binding]
526218007853	putative dimer interface [polypeptide binding]; other site
526218007854	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
526218007855	catalytic core [active]
526218007856	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
526218007857	putative alcohol dehydrogenase; Provisional; Region: PRK09860
526218007858	dimer interface [polypeptide binding]; other site
526218007859	active site
526218007860	metal binding site [ion binding]; metal-binding site
526218007861	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
526218007862	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
526218007863	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218007864	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
526218007865	amphipathic channel; other site
526218007866	Asn-Pro-Ala signature motifs; other site
526218007867	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
526218007868	MOSC domain; Region: MOSC; pfam03473
526218007869	3-alpha domain; Region: 3-alpha; pfam03475
526218007870	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
526218007871	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
526218007872	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526218007873	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526218007874	Cupin domain; Region: Cupin_2; pfam07883
526218007875	MSEP-CTERM protein; Region: MSEP-CTERM; TIGR04286
526218007876	exosortase K; Region: exosort_XrtK; TIGR04287
526218007877	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
526218007878	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
526218007879	active site
526218007880	catalytic tetrad [active]
526218007881	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
526218007882	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
526218007883	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
526218007884	active site
526218007885	catalytic tetrad [active]
526218007886	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
526218007887	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
526218007888	N-acetyl-D-glucosamine binding site [chemical binding]; other site
526218007889	catalytic residue [active]
526218007890	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218007891	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218007892	active site
526218007893	phosphorylation site [posttranslational modification]
526218007894	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
526218007895	active site
526218007896	P-loop; other site
526218007897	phosphorylation site [posttranslational modification]
526218007898	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
526218007899	alpha-mannosidase; Provisional; Region: PRK09819
526218007900	N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815
526218007901	active site
526218007902	metal binding site [ion binding]; metal-binding site
526218007903	catalytic site [active]
526218007904	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
526218007905	Transcriptional regulators [Transcription]; Region: PurR; COG1609
526218007906	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
526218007907	DNA binding site [nucleotide binding]
526218007908	domain linker motif; other site
526218007909	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
526218007910	ligand binding site [chemical binding]; other site
526218007911	dimerization interface [polypeptide binding]; other site
526218007912	DKNYY family; Region: DKNYY; pfam13644
526218007913	putative oxidoreductase; Provisional; Region: PRK10206
526218007914	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526218007915	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
526218007916	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
526218007917	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
526218007918	active site
526218007919	Na/Ca binding site [ion binding]; other site
526218007920	catalytic site [active]
526218007921	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
526218007922	active site
526218007923	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
526218007924	substrate binding site [chemical binding]; other site
526218007925	metal binding site [ion binding]; metal-binding site
526218007926	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
526218007927	PTS system sorbose-specific iic component; Region: EII-Sor; cl01506
526218007928	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021
526218007929	active site
526218007930	phosphorylation site [posttranslational modification]
526218007931	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
526218007932	active pocket/dimerization site; other site
526218007933	active site
526218007934	phosphorylation site [posttranslational modification]
526218007935	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
526218007936	intersubunit interface [polypeptide binding]; other site
526218007937	active site
526218007938	catalytic residue [active]
526218007939	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
526218007940	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
526218007941	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
526218007942	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
526218007943	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526218007944	FeS/SAM binding site; other site
526218007945	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
526218007946	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
526218007947	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
526218007948	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
526218007949	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
526218007950	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
526218007951	ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573
526218007952	dimerization interface [polypeptide binding]; other site
526218007953	active site
526218007954	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526218007955	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
526218007956	Walker A/P-loop; other site
526218007957	ATP binding site [chemical binding]; other site
526218007958	Q-loop/lid; other site
526218007959	ABC transporter signature motif; other site
526218007960	Walker B; other site
526218007961	D-loop; other site
526218007962	H-loop/switch region; other site
526218007963	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
526218007964	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526218007965	dimer interface [polypeptide binding]; other site
526218007966	conserved gate region; other site
526218007967	putative PBP binding loops; other site
526218007968	ABC-ATPase subunit interface; other site
526218007969	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
526218007970	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
526218007971	substrate binding pocket [chemical binding]; other site
526218007972	membrane-bound complex binding site; other site
526218007973	hinge residues; other site
526218007974	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
526218007975	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
526218007976	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526218007977	Walker A/P-loop; other site
526218007978	ATP binding site [chemical binding]; other site
526218007979	Q-loop/lid; other site
526218007980	ABC transporter signature motif; other site
526218007981	Walker B; other site
526218007982	D-loop; other site
526218007983	H-loop/switch region; other site
526218007984	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
526218007985	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
526218007986	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526218007987	Walker A/P-loop; other site
526218007988	ATP binding site [chemical binding]; other site
526218007989	Q-loop/lid; other site
526218007990	ABC transporter signature motif; other site
526218007991	Walker B; other site
526218007992	D-loop; other site
526218007993	H-loop/switch region; other site
526218007994	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
526218007995	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
526218007996	catalytic loop [active]
526218007997	iron binding site [ion binding]; other site
526218007998	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
526218007999	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
526218008000	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
526218008001	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
526218008002	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
526218008003	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
526218008004	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
526218008005	Cysteine-rich domain; Region: CCG; pfam02754
526218008006	Methyltransferase domain; Region: Methyltransf_23; pfam13489
526218008007	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526218008008	S-adenosylmethionine binding site [chemical binding]; other site
526218008009	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
526218008010	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964
526218008011	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526218008012	FeS/SAM binding site; other site
526218008013	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
526218008014	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526218008015	acyl-activating enzyme (AAE) consensus motif; other site
526218008016	active site
526218008017	AMP binding site [chemical binding]; other site
526218008018	Autotransporter beta-domain; Region: Autotransporter; smart00869
526218008019	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
526218008020	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
526218008021	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
526218008022	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
526218008023	dimer interface [polypeptide binding]; other site
526218008024	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526218008025	catalytic residue [active]
526218008026	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
526218008027	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
526218008028	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
526218008029	FeoA domain; Region: FeoA; pfam04023
526218008030	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
526218008031	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
526218008032	intersubunit interface [polypeptide binding]; other site
526218008033	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
526218008034	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
526218008035	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
526218008036	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
526218008037	ABC-ATPase subunit  interface; other site
526218008038	dimer interface [polypeptide binding]; other site
526218008039	putative PBP binding regions; other site
526218008040	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
526218008041	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
526218008042	ABC-ATPase subunit  interface; other site
526218008043	dimer interface [polypeptide binding]; other site
526218008044	putative PBP binding regions; other site
526218008045	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
526218008046	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526218008047	salt bridge; other site
526218008048	non-specific DNA binding site [nucleotide binding]; other site
526218008049	sequence-specific DNA binding site [nucleotide binding]; other site
526218008050	serine acetyltransferase; Region: PLN02357
526218008051	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
526218008052	haemagglutination activity domain; Region: Haemagg_act; pfam05860
526218008053	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
526218008054	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
526218008055	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
526218008056	TPR motif; other site
526218008057	binding surface
526218008058	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
526218008059	Protein export membrane protein; Region: SecD_SecF; cl14618
526218008060	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
526218008061	HlyD family secretion protein; Region: HlyD_3; pfam13437
526218008062	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
526218008063	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526218008064	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526218008065	aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824
526218008066	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
526218008067	potential frameshift: common BLAST hit: gi|257125616|ref|YP_003163730.1| anthranilate phosphoribosyltransferase
526218008068	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
526218008069	Glutamine amidotransferase class-I; Region: GATase; pfam00117
526218008070	glutamine binding [chemical binding]; other site
526218008071	catalytic triad [active]
526218008072	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
526218008073	anthranilate phosphoribosyltransferase; Region: trpD; TIGR01245
526218008074	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
526218008075	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
526218008076	active site
526218008077	ribulose/triose binding site [chemical binding]; other site
526218008078	phosphate binding site [ion binding]; other site
526218008079	substrate (anthranilate) binding pocket [chemical binding]; other site
526218008080	product (indole) binding pocket [chemical binding]; other site
526218008081	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
526218008082	active site
526218008083	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
526218008084	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
526218008085	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526218008086	catalytic residue [active]
526218008087	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
526218008088	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
526218008089	substrate binding site [chemical binding]; other site
526218008090	active site
526218008091	catalytic residues [active]
526218008092	heterodimer interface [polypeptide binding]; other site
526218008093	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526218008094	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526218008095	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
526218008096	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
526218008097	FAD binding domain; Region: FAD_binding_4; pfam01565
526218008098	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
526218008099	Protein of unknown function (DUF4125); Region: DUF4125; pfam13526
526218008100	Domain of unknown function (DUF4037); Region: DUF4037; pfam13228
526218008101	Tetratricopeptide repeat; Region: TPR_12; pfam13424
526218008102	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218008103	TPR motif; other site
526218008104	Tetratricopeptide repeat; Region: TPR_12; pfam13424
526218008105	binding surface
526218008106	Tetratricopeptide repeat; Region: TPR_12; pfam13424
526218008107	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218008108	binding surface
526218008109	TPR motif; other site
526218008110	Tetratricopeptide repeat; Region: TPR_12; pfam13424
526218008111	Amino acid permease; Region: AA_permease_2; pfam13520
526218008112	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
526218008113	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
526218008114	active site
526218008115	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
526218008116	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
526218008117	putative substrate binding region [chemical binding]; other site
526218008118	EamA-like transporter family; Region: EamA; pfam00892
526218008119	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
526218008120	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526218008121	active site
526218008122	motif I; other site
526218008123	motif II; other site
526218008124	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
526218008125	Protein of unknown function (DUF552); Region: DUF552; cl00775
526218008126	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
526218008127	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
526218008128	catalytic residue [active]
526218008129	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
526218008130	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526218008131	FeS/SAM binding site; other site
526218008132	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
526218008133	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
526218008134	active site
526218008135	substrate binding site [chemical binding]; other site
526218008136	metal binding site [ion binding]; metal-binding site
526218008137	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
526218008138	Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298
526218008139	NAD binding site [chemical binding]; other site
526218008140	sugar binding site [chemical binding]; other site
526218008141	divalent metal binding site [ion binding]; other site
526218008142	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
526218008143	dimer interface [polypeptide binding]; other site
526218008144	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
526218008145	PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005
526218008146	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
526218008147	active site turn [active]
526218008148	phosphorylation site [posttranslational modification]
526218008149	Initiator Replication protein; Region: Rep_3; pfam01051
526218008150	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
526218008151	Domain of unknown function DUF87; Region: DUF87; pfam01935
526218008152	AAA-like domain; Region: AAA_10; pfam12846
526218008153	Ubiquitin 3 binding protein But2 C-terminal domain; Region: But2; pfam09792
526218008154	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
526218008155	dimer interface [polypeptide binding]; other site
526218008156	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
526218008157	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526218008158	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526218008159	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
526218008160	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526218008161	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
526218008162	Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732
526218008163	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
526218008164	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
526218008165	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516
526218008166	PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515
526218008167	Initiator Replication protein; Region: Rep_3; pfam01051
526218008168	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
526218008169	Active_site [active]
526218008170	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
526218008171	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
526218008172	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
526218008173	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
526218008174	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
526218008175	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526218008176	Coenzyme A binding pocket [chemical binding]; other site
526218008177	Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803
526218008178	putative active site [active]
526218008179	YdjC motif; other site
526218008180	Mg binding site [ion binding]; other site
526218008181	putative homodimer interface [polypeptide binding]; other site
526218008182	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
526218008183	catalytic core [active]
526218008184	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
526218008185	beta-galactosidase; Region: BGL; TIGR03356
526218008186	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
526218008187	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
526218008188	NAD binding site [chemical binding]; other site
526218008189	sugar binding site [chemical binding]; other site
526218008190	divalent metal binding site [ion binding]; other site
526218008191	tetramer (dimer of dimers) interface [polypeptide binding]; other site
526218008192	dimer interface [polypeptide binding]; other site
526218008193	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
526218008194	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295
526218008195	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
526218008196	methionine cluster; other site
526218008197	active site
526218008198	phosphorylation site [posttranslational modification]
526218008199	metal binding site [ion binding]; metal-binding site
526218008200	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
526218008201	active site
526218008202	P-loop; other site
526218008203	phosphorylation site [posttranslational modification]
526218008204	Initiator Replication protein; Region: Rep_3; pfam01051
526218008205	Protein of unknown function (DUF419); Region: DUF419; cl15265
526218008206	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
526218008207	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
526218008208	Penicillinase repressor; Region: Pencillinase_R; pfam03965
526218008209	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
526218008210	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218008211	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
526218008212	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
526218008213	active site
526218008214	HIGH motif; other site
526218008215	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
526218008216	active site
526218008217	KMSKS motif; other site
526218008218	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
526218008219	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
526218008220	putative ligand binding site [chemical binding]; other site
526218008221	putative NAD binding site [chemical binding]; other site
526218008222	catalytic site [active]
526218008223	DKNYY family; Region: DKNYY; pfam13644
526218008224	DKNYY family; Region: DKNYY; pfam13644
526218008225	DKNYY family; Region: DKNYY; pfam13644
526218008226	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
526218008227	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
526218008228	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
526218008229	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
526218008230	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
526218008231	DNA binding site [nucleotide binding]
526218008232	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
526218008233	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
526218008234	Walker A motif; other site
526218008235	multifunctional aminopeptidase A; Provisional; Region: PRK00913
526218008236	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
526218008237	interface (dimer of trimers) [polypeptide binding]; other site
526218008238	Substrate-binding/catalytic site; other site
526218008239	Zn-binding sites [ion binding]; other site
526218008240	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
526218008241	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
526218008242	PYR/PP interface [polypeptide binding]; other site
526218008243	dimer interface [polypeptide binding]; other site
526218008244	TPP binding site [chemical binding]; other site
526218008245	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
526218008246	transketolase; Reviewed; Region: PRK05899
526218008247	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
526218008248	TPP-binding site [chemical binding]; other site
526218008249	dimer interface [polypeptide binding]; other site
526218008250	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
526218008251	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
526218008252	active site
526218008253	P-loop; other site
526218008254	phosphorylation site [posttranslational modification]
526218008255	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218008256	active site
526218008257	phosphorylation site [posttranslational modification]
526218008258	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
526218008259	HTH domain; Region: HTH_11; cl17392
526218008260	PRD domain; Region: PRD; pfam00874
526218008261	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
526218008262	active site
526218008263	P-loop; other site
526218008264	phosphorylation site [posttranslational modification]
526218008265	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218008266	active site
526218008267	phosphorylation site [posttranslational modification]
526218008268	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
526218008269	Autotransporter beta-domain; Region: Autotransporter; cl17461
526218008270	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
526218008271	PBP superfamily domain; Region: PBP_like_2; cl17296
526218008272	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
526218008273	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526218008274	homodimer interface [polypeptide binding]; other site
526218008275	catalytic residue [active]
526218008276	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
526218008277	HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236
526218008278	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
526218008279	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
526218008280	active site
526218008281	metal binding site [ion binding]; metal-binding site
526218008282	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
526218008283	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
526218008284	putative substrate binding site [chemical binding]; other site
526218008285	putative ATP binding site [chemical binding]; other site
526218008286	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
526218008287	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
526218008288	intersubunit interface [polypeptide binding]; other site
526218008289	active site
526218008290	zinc binding site [ion binding]; other site
526218008291	Na+ binding site [ion binding]; other site
526218008292	galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309
526218008293	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
526218008294	putative NAD(P) binding site [chemical binding]; other site
526218008295	catalytic Zn binding site [ion binding]; other site
526218008296	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
526218008297	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
526218008298	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218008299	active site
526218008300	phosphorylation site [posttranslational modification]
526218008301	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
526218008302	active site
526218008303	P-loop; other site
526218008304	phosphorylation site [posttranslational modification]
526218008305	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
526218008306	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
526218008307	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
526218008308	Autotransporter beta-domain; Region: Autotransporter; smart00869
526218008309	DKNYY family; Region: DKNYY; pfam13644
526218008310	DKNYY family; Region: DKNYY; pfam13644
526218008311	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
526218008312	trimer interface [polypeptide binding]; other site
526218008313	active site
526218008314	substrate binding site [chemical binding]; other site
526218008315	CoA binding site [chemical binding]; other site
526218008316	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
526218008317	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_4; cd13144
526218008318	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
526218008319	active pocket/dimerization site; other site
526218008320	active site
526218008321	phosphorylation site [posttranslational modification]
526218008322	PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855
526218008323	PTS system sorbose-specific iic component; Region: EII-Sor; cl01506
526218008324	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
526218008325	active site
526218008326	phosphorylation site [posttranslational modification]
526218008327	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
526218008328	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
526218008329	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
526218008330	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
526218008331	active site
526218008332	dimer interface [polypeptide binding]; other site
526218008333	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
526218008334	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
526218008335	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
526218008336	L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235
526218008337	putative NAD(P) binding site [chemical binding]; other site
526218008338	catalytic Zn binding site [ion binding]; other site
526218008339	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
526218008340	active site
526218008341	P-loop; other site
526218008342	phosphorylation site [posttranslational modification]
526218008343	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
526218008344	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218008345	active site
526218008346	phosphorylation site [posttranslational modification]
526218008347	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
526218008348	intersubunit interface [polypeptide binding]; other site
526218008349	active site
526218008350	catalytic residue [active]
526218008351	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
526218008352	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
526218008353	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
526218008354	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
526218008355	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526218008356	DNA-binding site [nucleotide binding]; DNA binding site
526218008357	UTRA domain; Region: UTRA; pfam07702
526218008358	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526218008359	MarR family; Region: MarR; pfam01047
526218008360	Flavin Reductases; Region: FlaRed; cl00801
526218008361	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526218008362	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526218008363	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
526218008364	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
526218008365	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526218008366	Walker A/P-loop; other site
526218008367	ATP binding site [chemical binding]; other site
526218008368	Q-loop/lid; other site
526218008369	ABC transporter signature motif; other site
526218008370	Walker B; other site
526218008371	D-loop; other site
526218008372	H-loop/switch region; other site
526218008373	Ubiquitin-like proteins; Region: UBQ; cl00155
526218008374	TOBE domain; Region: TOBE_2; pfam08402
526218008375	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
526218008376	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526218008377	dimer interface [polypeptide binding]; other site
526218008378	conserved gate region; other site
526218008379	putative PBP binding loops; other site
526218008380	ABC-ATPase subunit interface; other site
526218008381	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
526218008382	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
526218008383	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
526218008384	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
526218008385	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
526218008386	active site
526218008387	4-aminobutyrate aminotransferase; Provisional; Region: PRK06082
526218008388	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
526218008389	inhibitor-cofactor binding pocket; inhibition site
526218008390	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526218008391	catalytic residue [active]
526218008392	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
526218008393	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526218008394	motif II; other site
526218008395	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
526218008396	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
526218008397	catalytic residue [active]
526218008398	Domain of unknown function (DUF2828); Region: DUF2828; pfam11443
526218008399	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
526218008400	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526218008401	active site
526218008402	motif I; other site
526218008403	motif II; other site
526218008404	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
526218008405	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
526218008406	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
526218008407	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021
526218008408	active site
526218008409	phosphorylation site [posttranslational modification]
526218008410	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
526218008411	active pocket/dimerization site; other site
526218008412	active site
526218008413	phosphorylation site [posttranslational modification]
526218008414	CAAX protease self-immunity; Region: Abi; pfam02517
526218008415	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
526218008416	Transcriptional regulators [Transcription]; Region: PurR; COG1609
526218008417	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
526218008418	DNA binding site [nucleotide binding]
526218008419	domain linker motif; other site
526218008420	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
526218008421	ligand binding site [chemical binding]; other site
526218008422	dimerization interface [polypeptide binding]; other site
526218008423	Septum formation initiator; Region: DivIC; cl17659
526218008424	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218008425	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218008426	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
526218008427	classical (c) SDRs; Region: SDR_c; cd05233
526218008428	NAD(P) binding site [chemical binding]; other site
526218008429	active site
526218008430	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
526218008431	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
526218008432	active site
526218008433	catalytic tetrad [active]
526218008434	Predicted transcriptional regulators [Transcription]; Region: COG1733
526218008435	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
526218008436	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526218008437	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526218008438	DNA binding residues [nucleotide binding]
526218008439	dimerization interface [polypeptide binding]; other site
526218008440	carbamate kinase; Reviewed; Region: PRK12686
526218008441	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
526218008442	putative substrate binding site [chemical binding]; other site
526218008443	nucleotide binding site [chemical binding]; other site
526218008444	nucleotide binding site [chemical binding]; other site
526218008445	homodimer interface [polypeptide binding]; other site
526218008446	agmatine deiminase; Provisional; Region: PRK13551
526218008447	agmatine deiminase; Region: agmatine_aguA; TIGR03380
526218008448	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
526218008449	putrescine carbamoyltransferase; Provisional; Region: PRK02255
526218008450	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
526218008451	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
526218008452	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
526218008453	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
526218008454	ligand binding site [chemical binding]; other site
526218008455	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
526218008456	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
526218008457	TM-ABC transporter signature motif; other site
526218008458	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
526218008459	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
526218008460	Walker A/P-loop; other site
526218008461	ATP binding site [chemical binding]; other site
526218008462	Q-loop/lid; other site
526218008463	ABC transporter signature motif; other site
526218008464	Walker B; other site
526218008465	D-loop; other site
526218008466	H-loop/switch region; other site
526218008467	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
526218008468	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
526218008469	nucleotide binding site [chemical binding]; other site
526218008470	MarR family; Region: MarR_2; pfam12802
526218008471	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
526218008472	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
526218008473	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
526218008474	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
526218008475	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
526218008476	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
526218008477	galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622
526218008478	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
526218008479	methionine cluster; other site
526218008480	active site
526218008481	phosphorylation site [posttranslational modification]
526218008482	metal binding site [ion binding]; metal-binding site
526218008483	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295
526218008484	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
526218008485	PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565
526218008486	active site
526218008487	P-loop; other site
526218008488	phosphorylation site [posttranslational modification]
526218008489	6-phospho-beta-galactosidase; Provisional; Region: PRK13511
526218008490	beta-galactosidase; Region: BGL; TIGR03356
526218008491	DKNYY family; Region: DKNYY; pfam13644
526218008492	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
526218008493	4Fe-4S binding domain; Region: Fer4; pfam00037
526218008494	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
526218008495	Putative Fe-S cluster; Region: FeS; cl17515
526218008496	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
526218008497	PAS domain; Region: PAS_9; pfam13426
526218008498	putative active site [active]
526218008499	heme pocket [chemical binding]; other site
526218008500	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
526218008501	[FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105
526218008502	4Fe-4S binding domain; Region: Fer4; cl02805
526218008503	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
526218008504	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
526218008505	catalytic core [active]
526218008506	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
526218008507	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
526218008508	beta-galactosidase; Region: BGL; TIGR03356
526218008509	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
526218008510	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
526218008511	active site turn [active]
526218008512	phosphorylation site [posttranslational modification]
526218008513	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
526218008514	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
526218008515	HPr interaction site; other site
526218008516	glycerol kinase (GK) interaction site [polypeptide binding]; other site
526218008517	active site
526218008518	phosphorylation site [posttranslational modification]
526218008519	transcriptional antiterminator BglG; Provisional; Region: PRK09772
526218008520	CAT RNA binding domain; Region: CAT_RBD; pfam03123
526218008521	PRD domain; Region: PRD; pfam00874
526218008522	PRD domain; Region: PRD; pfam00874
526218008523	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
526218008524	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526218008525	DNA-binding site [nucleotide binding]; DNA binding site
526218008526	UTRA domain; Region: UTRA; pfam07702
526218008527	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
526218008528	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
526218008529	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
526218008530	active pocket/dimerization site; other site
526218008531	active site
526218008532	phosphorylation site [posttranslational modification]
526218008533	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
526218008534	active site
526218008535	phosphorylation site [posttranslational modification]
526218008536	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
526218008537	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
526218008538	Transcriptional regulator [Transcription]; Region: LysR; COG0583
526218008539	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
526218008540	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
526218008541	dimerization interface [polypeptide binding]; other site
526218008542	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
526218008543	Transcriptional regulator [Transcription]; Region: IclR; COG1414
526218008544	Bacterial transcriptional regulator; Region: IclR; pfam01614
526218008545	rhamnose-proton symporter; Provisional; Region: PRK13499
526218008546	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
526218008547	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526218008548	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
526218008549	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
526218008550	Amidohydrolase; Region: Amidohydro_2; pfam04909
526218008551	Domain of unknown function (DUF718); Region: DUF718; pfam05336
526218008552	N-acetylneuraminate lyase; Provisional; Region: PRK04147
526218008553	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
526218008554	inhibitor site; inhibition site
526218008555	active site
526218008556	dimer interface [polypeptide binding]; other site
526218008557	catalytic residue [active]
526218008558	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
526218008559	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
526218008560	CoA-transferase family III; Region: CoA_transf_3; pfam02515
526218008561	Acyl dehydratase [Lipid metabolism]; Region: MaoC; COG2030
526218008562	active site 2 [active]
526218008563	active site 1 [active]
526218008564	Uncharacterized conserved protein [Function unknown]; Region: COG5361
526218008565	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
526218008566	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
526218008567	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
526218008568	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
526218008569	motif II; other site
526218008570	Flavodoxin domain; Region: Flavodoxin_5; pfam12724
526218008571	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
526218008572	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
526218008573	LysR substrate binding domain; Region: LysR_substrate; pfam03466
526218008574	dimerization interface [polypeptide binding]; other site
526218008575	Chromate transporter; Region: Chromate_transp; pfam02417
526218008576	Chromate transporter; Region: Chromate_transp; pfam02417
526218008577	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
526218008578	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
526218008579	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
526218008580	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
526218008581	active site
526218008582	catalytic tetrad [active]
526218008583	Protein of unknown function (DUF523); Region: DUF523; pfam04463
526218008584	photolyase PhrII; Region: phr2; TIGR00591
526218008585	DNA photolyase; Region: DNA_photolyase; pfam00875
526218008586	Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile.  CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902
526218008587	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
526218008588	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
526218008589	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241
526218008590	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526218008591	putative metal binding site [ion binding]; other site
526218008592	4Fe-4S binding domain; Region: Fer4_5; pfam12801
526218008593	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
526218008594	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
526218008595	Predicted membrane protein [Function unknown]; Region: COG2855
526218008596	SnoaL-like domain; Region: SnoaL_2; pfam12680
526218008597	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526218008598	MarR family; Region: MarR_2; cl17246
526218008599	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526218008600	Walker A/P-loop; other site
526218008601	ATP binding site [chemical binding]; other site
526218008602	Q-loop/lid; other site
526218008603	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526218008604	ABC transporter signature motif; other site
526218008605	Walker B; other site
526218008606	D-loop; other site
526218008607	H-loop/switch region; other site
526218008608	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526218008609	AAA domain; Region: AAA_21; pfam13304
526218008610	Walker A/P-loop; other site
526218008611	ATP binding site [chemical binding]; other site
526218008612	Q-loop/lid; other site
526218008613	ABC transporter signature motif; other site
526218008614	Walker B; other site
526218008615	D-loop; other site
526218008616	H-loop/switch region; other site
526218008617	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
526218008618	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
526218008619	SCP-2 sterol transfer family; Region: SCP2; pfam02036
526218008620	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526218008621	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526218008622	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218008623	DKNYY family; Region: DKNYY; pfam13644
526218008624	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
526218008625	transmembrane helices; other site
526218008626	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
526218008627	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
526218008628	putative oxidoreductase; Provisional; Region: PRK08275
526218008629	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
526218008630	MarR family; Region: MarR_2; pfam12802
526218008631	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
526218008632	dimer interface [polypeptide binding]; other site
526218008633	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526218008634	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526218008635	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
526218008636	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526218008637	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218008638	binding surface
526218008639	TPR motif; other site
526218008640	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218008641	binding surface
526218008642	TPR motif; other site
526218008643	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
526218008644	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
526218008645	Walker A/P-loop; other site
526218008646	ATP binding site [chemical binding]; other site
526218008647	Q-loop/lid; other site
526218008648	ABC transporter signature motif; other site
526218008649	Walker B; other site
526218008650	D-loop; other site
526218008651	H-loop/switch region; other site
526218008652	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
526218008653	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526218008654	dimer interface [polypeptide binding]; other site
526218008655	conserved gate region; other site
526218008656	ABC-ATPase subunit interface; other site
526218008657	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
526218008658	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
526218008659	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
526218008660	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
526218008661	metal binding site [ion binding]; metal-binding site
526218008662	Protein of unknown function (DUF2023); Region: DUF2023; pfam09633
526218008663	flavodoxin FldA; Validated; Region: PRK09267
526218008664	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
526218008665	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
526218008666	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
526218008667	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
526218008668	substrate binding site [chemical binding]; other site
526218008669	ATP binding site [chemical binding]; other site
526218008670	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
526218008671	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
526218008672	TM-ABC transporter signature motif; other site
526218008673	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
526218008674	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
526218008675	Walker A/P-loop; other site
526218008676	ATP binding site [chemical binding]; other site
526218008677	Q-loop/lid; other site
526218008678	ABC transporter signature motif; other site
526218008679	Walker B; other site
526218008680	D-loop; other site
526218008681	H-loop/switch region; other site
526218008682	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
526218008683	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_12; cd06322
526218008684	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
526218008685	putative ligand binding site [chemical binding]; other site
526218008686	Transcriptional regulators [Transcription]; Region: PurR; COG1609
526218008687	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
526218008688	DNA binding site [nucleotide binding]
526218008689	domain linker motif; other site
526218008690	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
526218008691	ligand binding site [chemical binding]; other site
526218008692	dimerization interface [polypeptide binding]; other site
526218008693	DKNYY family; Region: DKNYY; pfam13644
526218008694	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
526218008695	EamA-like transporter family; Region: EamA; pfam00892
526218008696	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
526218008697	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
526218008698	generic binding surface II; other site
526218008699	ssDNA binding site; other site
526218008700	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526218008701	ATP binding site [chemical binding]; other site
526218008702	putative Mg++ binding site [ion binding]; other site
526218008703	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526218008704	nucleotide binding region [chemical binding]; other site
526218008705	ATP-binding site [chemical binding]; other site
526218008706	hypothetical protein; Validated; Region: PRK00110
526218008707	TPR repeat; Region: TPR_11; pfam13414
526218008708	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218008709	binding surface
526218008710	TPR motif; other site
526218008711	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218008712	binding surface
526218008713	TPR motif; other site
526218008714	Tetratricopeptide repeat; Region: TPR_16; pfam13432
526218008715	TPR repeat; Region: TPR_11; pfam13414
526218008716	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218008717	binding surface
526218008718	TPR motif; other site
526218008719	Tetratricopeptide repeat; Region: TPR_12; pfam13424
526218008720	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
526218008721	intersubunit interface [polypeptide binding]; other site
526218008722	active site
526218008723	Zn2+ binding site [ion binding]; other site
526218008724	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171
526218008725	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
526218008726	putative ligand binding site [chemical binding]; other site
526218008727	putative NAD binding site [chemical binding]; other site
526218008728	catalytic site [active]
526218008729	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
526218008730	PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611
526218008731	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
526218008732	active site
526218008733	P-loop; other site
526218008734	phosphorylation site [posttranslational modification]
526218008735	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218008736	active site
526218008737	phosphorylation site [posttranslational modification]
526218008738	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
526218008739	Mga helix-turn-helix domain; Region: Mga; pfam05043
526218008740	PRD domain; Region: PRD; pfam00874
526218008741	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
526218008742	active site
526218008743	P-loop; other site
526218008744	phosphorylation site [posttranslational modification]
526218008745	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
526218008746	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
526218008747	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
526218008748	Methyltransferase domain; Region: Methyltransf_31; pfam13847
526218008749	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526218008750	S-adenosylmethionine binding site [chemical binding]; other site
526218008751	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
526218008752	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
526218008753	active site
526218008754	Zn binding site [ion binding]; other site
526218008755	Domain of unknown function (DUF4280); Region: DUF4280; pfam14107
526218008756	Protein of unknown function (DUF502); Region: DUF502; cl01107
526218008757	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
526218008758	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
526218008759	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
526218008760	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
526218008761	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
526218008762	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
526218008763	ATP-binding site [chemical binding]; other site
526218008764	Sugar specificity; other site
526218008765	Pyrimidine base specificity; other site
526218008766	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
526218008767	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526218008768	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
526218008769	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218008770	active site
526218008771	phosphorylation site [posttranslational modification]
526218008772	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
526218008773	Domain of unknown function (DUF4253); Region: DUF4253; pfam14062
526218008774	manganese transport protein MntH; Reviewed; Region: PRK00701
526218008775	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
526218008776	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
526218008777	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
526218008778	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
526218008779	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
526218008780	DKNYY family; Region: DKNYY; pfam13644
526218008781	DKNYY family; Region: DKNYY; pfam13644
526218008782	DKNYY family; Region: DKNYY; pfam13644
526218008783	DKNYY family; Region: DKNYY; pfam13644
526218008784	putative recombination protein RecB; Provisional; Region: PRK13909
526218008785	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526218008786	Major Facilitator Superfamily; Region: MFS_1; pfam07690
526218008787	putative substrate translocation pore; other site
526218008788	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526218008789	phosphoenolpyruvate synthase; Validated; Region: PRK06241
526218008790	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
526218008791	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
526218008792	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
526218008793	putative active site [active]
526218008794	nucleotide binding site [chemical binding]; other site
526218008795	nudix motif; other site
526218008796	putative metal binding site [ion binding]; other site
526218008797	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
526218008798	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
526218008799	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
526218008800	Predicted transcriptional regulators [Transcription]; Region: COG1733
526218008801	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
526218008802	Domain of unknown function (DUF1848); Region: DUF1848; pfam08902
526218008803	MarR family; Region: MarR_2; pfam12802
526218008804	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
526218008805	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526218008806	FeS/SAM binding site; other site
526218008807	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111
526218008808	Class III ribonucleotide reductase; Region: RNR_III; cd01675
526218008809	effector binding site; other site
526218008810	active site
526218008811	Zn binding site [ion binding]; other site
526218008812	glycine loop; other site
526218008813	alpha-mannosidase; Provisional; Region: PRK09819
526218008814	N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815
526218008815	active site
526218008816	metal binding site [ion binding]; metal-binding site
526218008817	catalytic site [active]
526218008818	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
526218008819	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
526218008820	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218008821	active site
526218008822	phosphorylation site [posttranslational modification]
526218008823	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
526218008824	active site
526218008825	P-loop; other site
526218008826	phosphorylation site [posttranslational modification]
526218008827	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
526218008828	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
526218008829	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526218008830	DNA-binding site [nucleotide binding]; DNA binding site
526218008831	UTRA domain; Region: UTRA; pfam07702
526218008832	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
526218008833	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
526218008834	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
526218008835	HTH domain; Region: HTH_11; pfam08279
526218008836	3H domain; Region: 3H; pfam02829
526218008837	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
526218008838	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
526218008839	putative dimer interface [polypeptide binding]; other site
526218008840	[2Fe-2S] cluster binding site [ion binding]; other site
526218008841	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
526218008842	dimer interface [polypeptide binding]; other site
526218008843	[2Fe-2S] cluster binding site [ion binding]; other site
526218008844	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
526218008845	SLBB domain; Region: SLBB; pfam10531
526218008846	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
526218008847	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
526218008848	4Fe-4S binding domain; Region: Fer4; pfam00037
526218008849	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
526218008850	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
526218008851	catalytic loop [active]
526218008852	iron binding site [ion binding]; other site
526218008853	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
526218008854	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
526218008855	4Fe-4S binding domain; Region: Fer4; pfam00037
526218008856	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
526218008857	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
526218008858	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
526218008859	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526218008860	DNA-binding site [nucleotide binding]; DNA binding site
526218008861	Transcriptional regulators [Transcription]; Region: FadR; COG2186
526218008862	FCD domain; Region: FCD; pfam07729
526218008863	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
526218008864	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
526218008865	NADP binding site [chemical binding]; other site
526218008866	homopentamer interface [polypeptide binding]; other site
526218008867	substrate binding site [chemical binding]; other site
526218008868	active site
526218008869	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
526218008870	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
526218008871	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
526218008872	active site
526218008873	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
526218008874	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
526218008875	DEAD/DEAH box helicase; Region: DEAD; pfam00270
526218008876	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
526218008877	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
526218008878	DNA binding residues [nucleotide binding]
526218008879	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
526218008880	drug binding residues [chemical binding]; other site
526218008881	dimer interface [polypeptide binding]; other site
526218008882	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
526218008883	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
526218008884	conserved cys residue [active]
526218008885	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
526218008886	dimer interface [polypeptide binding]; other site
526218008887	FMN binding site [chemical binding]; other site
526218008888	Predicted transcriptional regulator [Transcription]; Region: COG1959
526218008889	Transcriptional regulator; Region: Rrf2; pfam02082
526218008890	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
526218008891	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
526218008892	dimer interface [polypeptide binding]; other site
526218008893	PYR/PP interface [polypeptide binding]; other site
526218008894	TPP binding site [chemical binding]; other site
526218008895	substrate binding site [chemical binding]; other site
526218008896	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
526218008897	Domain of unknown function; Region: EKR; smart00890
526218008898	4Fe-4S binding domain; Region: Fer4_6; pfam12837
526218008899	4Fe-4S binding domain; Region: Fer4; pfam00037
526218008900	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
526218008901	TPP-binding site [chemical binding]; other site
526218008902	dimer interface [polypeptide binding]; other site
526218008903	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
526218008904	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
526218008905	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
526218008906	protein binding site [polypeptide binding]; other site
526218008907	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
526218008908	protein binding site [polypeptide binding]; other site
526218008909	putative oxidoreductase; Provisional; Region: PRK11445
526218008910	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
526218008911	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
526218008912	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526218008913	S-adenosylmethionine binding site [chemical binding]; other site
526218008914	Uncharacterized conserved protein [Function unknown]; Region: COG2013
526218008915	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
526218008916	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
526218008917	metal binding site [ion binding]; metal-binding site
526218008918	dimer interface [polypeptide binding]; other site
526218008919	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
526218008920	acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910
526218008921	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
526218008922	metal binding site [ion binding]; metal-binding site
526218008923	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
526218008924	active site
526218008925	tetramer interface [polypeptide binding]; other site
526218008926	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
526218008927	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
526218008928	TM-ABC transporter signature motif; other site
526218008929	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
526218008930	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
526218008931	TM-ABC transporter signature motif; other site
526218008932	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
526218008933	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526218008934	Walker A/P-loop; other site
526218008935	ATP binding site [chemical binding]; other site
526218008936	Q-loop/lid; other site
526218008937	ABC transporter signature motif; other site
526218008938	Walker B; other site
526218008939	D-loop; other site
526218008940	H-loop/switch region; other site
526218008941	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
526218008942	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
526218008943	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
526218008944	ligand binding site [chemical binding]; other site
526218008945	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
526218008946	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
526218008947	substrate binding site [chemical binding]; other site
526218008948	dimer interface [polypeptide binding]; other site
526218008949	ATP binding site [chemical binding]; other site
526218008950	Transcriptional regulators [Transcription]; Region: PurR; COG1609
526218008951	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
526218008952	DNA binding site [nucleotide binding]
526218008953	domain linker motif; other site
526218008954	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
526218008955	ligand binding site [chemical binding]; other site
526218008956	dimerization interface [polypeptide binding]; other site
526218008957	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
526218008958	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
526218008959	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
526218008960	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
526218008961	putative ADP-binding pocket [chemical binding]; other site
526218008962	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
526218008963	EamA-like transporter family; Region: EamA; pfam00892
526218008964	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
526218008965	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
526218008966	NAD(P) binding site [chemical binding]; other site
526218008967	homotetramer interface [polypeptide binding]; other site
526218008968	homodimer interface [polypeptide binding]; other site
526218008969	active site
526218008970	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
526218008971	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
526218008972	2-oxoacid ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11869
526218008973	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
526218008974	TPP-binding site [chemical binding]; other site
526218008975	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
526218008976	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
526218008977	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558
526218008978	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
526218008979	dimer interface [polypeptide binding]; other site
526218008980	PYR/PP interface [polypeptide binding]; other site
526218008981	TPP binding site [chemical binding]; other site
526218008982	substrate binding site [chemical binding]; other site
526218008983	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218008984	binding surface
526218008985	TPR motif; other site
526218008986	META domain; Region: META; pfam03724
526218008987	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
526218008988	active site
526218008989	DNA binding site [nucleotide binding]
526218008990	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
526218008991	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
526218008992	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
526218008993	active site
526218008994	HIGH motif; other site
526218008995	KMSK motif region; other site
526218008996	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
526218008997	tRNA binding surface [nucleotide binding]; other site
526218008998	anticodon binding site; other site
526218008999	Uncharacterized BCR, COG1636; Region: DUF208; pfam02677
526218009000	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
526218009001	Predicted transcriptional regulator [Transcription]; Region: COG2378
526218009002	HTH domain; Region: HTH_11; pfam08279
526218009003	WYL domain; Region: WYL; pfam13280
526218009004	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
526218009005	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
526218009006	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
526218009007	DNA polymerase III subunit delta'; Validated; Region: PRK08485
526218009008	rod shape-determining protein MreB; Provisional; Region: PRK13930
526218009009	MreB and similar proteins; Region: MreB_like; cd10225
526218009010	nucleotide binding site [chemical binding]; other site
526218009011	Mg binding site [ion binding]; other site
526218009012	putative protofilament interaction site [polypeptide binding]; other site
526218009013	RodZ interaction site [polypeptide binding]; other site
526218009014	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
526218009015	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
526218009016	active site
526218009017	HIGH motif; other site
526218009018	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
526218009019	KMSKS motif; other site
526218009020	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
526218009021	tRNA binding surface [nucleotide binding]; other site
526218009022	anticodon binding site; other site
526218009023	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
526218009024	substrate binding site; other site
526218009025	dimer interface; other site
526218009026	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
526218009027	MutS domain III; Region: MutS_III; pfam05192
526218009028	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
526218009029	Walker A/P-loop; other site
526218009030	ATP binding site [chemical binding]; other site
526218009031	Q-loop/lid; other site
526218009032	ABC transporter signature motif; other site
526218009033	Walker B; other site
526218009034	D-loop; other site
526218009035	H-loop/switch region; other site
526218009036	Smr domain; Region: Smr; pfam01713
526218009037	Transcriptional regulators [Transcription]; Region: PurR; COG1609
526218009038	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
526218009039	DNA binding site [nucleotide binding]
526218009040	domain linker motif; other site
526218009041	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
526218009042	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
526218009043	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
526218009044	active site turn [active]
526218009045	phosphorylation site [posttranslational modification]
526218009046	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
526218009047	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
526218009048	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
526218009049	substrate binding [chemical binding]; other site
526218009050	active site
526218009051	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
526218009052	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
526218009053	Hinge domain of cleavage stimulation factor subunit 2; Region: CSTF2_hinge; pfam14327
526218009054	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
526218009055	bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110
526218009056	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
526218009057	active site turn [active]
526218009058	phosphorylation site [posttranslational modification]
526218009059	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
526218009060	Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298
526218009061	NAD binding site [chemical binding]; other site
526218009062	sugar binding site [chemical binding]; other site
526218009063	divalent metal binding site [ion binding]; other site
526218009064	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
526218009065	dimer interface [polypeptide binding]; other site
526218009066	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
526218009067	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
526218009068	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
526218009069	putative active site [active]
526218009070	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
526218009071	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
526218009072	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
526218009073	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
526218009074	minor groove reading motif; other site
526218009075	helix-hairpin-helix signature motif; other site
526218009076	substrate binding pocket [chemical binding]; other site
526218009077	active site
526218009078	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
526218009079	Uncharacterized conserved protein [Function unknown]; Region: COG1739
526218009080	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
526218009081	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
526218009082	Peptidase family M50; Region: Peptidase_M50; pfam02163
526218009083	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
526218009084	active site
526218009085	putative substrate binding region [chemical binding]; other site
526218009086	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
526218009087	?-D-glucose-1-phosphatase; Provisional; Region: PRK09456
526218009088	Competence protein; Region: Competence; pfam03772
526218009089	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
526218009090	RuvA N terminal domain; Region: RuvA_N; pfam01330
526218009091	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
526218009092	glutamate racemase; Provisional; Region: PRK00865
526218009093	Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152
526218009094	putative homodimer interface [polypeptide binding]; other site
526218009095	putative homotetramer interface [polypeptide binding]; other site
526218009096	allosteric switch controlling residues; other site
526218009097	putative metal binding site [ion binding]; other site
526218009098	putative homodimer-homodimer interface [polypeptide binding]; other site
526218009099	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
526218009100	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
526218009101	metal-binding site [ion binding]
526218009102	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
526218009103	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
526218009104	metal-binding site [ion binding]
526218009105	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
526218009106	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526218009107	motif II; other site
526218009108	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
526218009109	metal-binding site [ion binding]
526218009110	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
526218009111	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
526218009112	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
526218009113	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526218009114	active site
526218009115	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
526218009116	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
526218009117	catalytic residues [active]
526218009118	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
526218009119	dimer interface [polypeptide binding]; other site
526218009120	catalytic triad [active]
526218009121	peroxidatic and resolving cysteines [active]
526218009122	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
526218009123	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526218009124	non-specific DNA binding site [nucleotide binding]; other site
526218009125	salt bridge; other site
526218009126	sequence-specific DNA binding site [nucleotide binding]; other site
526218009127	Cupin domain; Region: Cupin_2; pfam07883
526218009128	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
526218009129	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
526218009130	active site
526218009131	nucleophile elbow; other site
526218009132	Surface antigen; Region: Bac_surface_Ag; pfam01103
526218009133	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
526218009134	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526218009135	active site
526218009136	phosphorylation site [posttranslational modification]
526218009137	intermolecular recognition site; other site
526218009138	dimerization interface [polypeptide binding]; other site
526218009139	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
526218009140	DNA binding site [nucleotide binding]
526218009141	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
526218009142	HAMP domain; Region: HAMP; pfam00672
526218009143	dimerization interface [polypeptide binding]; other site
526218009144	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
526218009145	dimer interface [polypeptide binding]; other site
526218009146	phosphorylation site [posttranslational modification]
526218009147	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526218009148	ATP binding site [chemical binding]; other site
526218009149	Mg2+ binding site [ion binding]; other site
526218009150	G-X-G motif; other site
526218009151	Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627
526218009152	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
526218009153	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
526218009154	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
526218009155	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
526218009156	Ligand binding site; other site
526218009157	Putative Catalytic site; other site
526218009158	DXD motif; other site
526218009159	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
526218009160	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
526218009161	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
526218009162	putative lipid kinase; Reviewed; Region: PRK13059
526218009163	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
526218009164	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
526218009165	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
526218009166	active site
526218009167	metal binding site [ion binding]; metal-binding site
526218009168	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
526218009169	active pocket/dimerization site; other site
526218009170	active site
526218009171	phosphorylation site [posttranslational modification]
526218009172	PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855
526218009173	PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757
526218009174	PTS system N-acetylgalactosamine-specific transporter subunit IIB; Provisional; Region: PRK09756
526218009175	active site
526218009176	phosphorylation site [posttranslational modification]
526218009177	Initiator Replication protein; Region: Rep_3; pfam01051
526218009178	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
526218009179	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
526218009180	active site
526218009181	dimer interface [polypeptide binding]; other site
526218009182	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
526218009183	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
526218009184	active site
526218009185	trimer interface [polypeptide binding]; other site
526218009186	allosteric site; other site
526218009187	active site lid [active]
526218009188	hexamer (dimer of trimers) interface [polypeptide binding]; other site
526218009189	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
526218009190	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
526218009191	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
526218009192	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
526218009193	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
526218009194	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
526218009195	LytTr DNA-binding domain; Region: LytTR; pfam04397
526218009196	MltA-interacting protein MipA; Region: MipA; cl01504
526218009197	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526218009198	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526218009199	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218009200	Domain of unknown function (DUF4407); Region: DUF4407; pfam14362
526218009201	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526218009202	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
526218009203	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526218009204	Coenzyme A binding pocket [chemical binding]; other site
526218009205	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
526218009206	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526218009207	putative DNA binding site [nucleotide binding]; other site
526218009208	putative Zn2+ binding site [ion binding]; other site
526218009209	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
526218009210	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218009211	active site
526218009212	phosphorylation site [posttranslational modification]
526218009213	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
526218009214	intersubunit interface [polypeptide binding]; other site
526218009215	active site
526218009216	catalytic residue [active]
526218009217	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
526218009218	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
526218009219	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
526218009220	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
526218009221	active site
526218009222	catalytic tetrad [active]
526218009223	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
526218009224	active site
526218009225	P-loop; other site
526218009226	phosphorylation site [posttranslational modification]
526218009227	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526218009228	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526218009229	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
526218009230	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218009231	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
526218009232	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
526218009233	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
526218009234	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218009235	binding surface
526218009236	TPR motif; other site
526218009237	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218009238	binding surface
526218009239	TPR motif; other site
526218009240	Tetratricopeptide repeat; Region: TPR_12; pfam13424
526218009241	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218009242	binding surface
526218009243	TPR motif; other site
526218009244	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
526218009245	active site
526218009246	catalytic triad [active]
526218009247	oxyanion hole [active]
526218009248	Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848
526218009249	catalytic triad [active]
526218009250	putative active site [active]
526218009251	Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625
526218009252	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
526218009253	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218009254	Transcriptional regulators [Transcription]; Region: MarR; COG1846
526218009255	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
526218009256	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526218009257	Coenzyme A binding pocket [chemical binding]; other site
526218009258	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
526218009259	active site
526218009260	tetramer interface [polypeptide binding]; other site
526218009261	DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402
526218009262	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
526218009263	ligand binding site [chemical binding]; other site
526218009264	flexible hinge region; other site
526218009265	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
526218009266	Domain of unknown function (DUF4280); Region: DUF4280; pfam14107
526218009267	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
526218009268	ligand binding site [chemical binding]; other site
526218009269	active site
526218009270	UGI interface [polypeptide binding]; other site
526218009271	catalytic site [active]
526218009272	BioY family; Region: BioY; pfam02632
526218009273	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
526218009274	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
526218009275	acyl-activating enzyme (AAE) consensus motif; other site
526218009276	putative AMP binding site [chemical binding]; other site
526218009277	putative active site [active]
526218009278	putative CoA binding site [chemical binding]; other site
526218009279	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
526218009280	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
526218009281	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
526218009282	putative acyl-acceptor binding pocket; other site
526218009283	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
526218009284	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
526218009285	substrate binding site [chemical binding]; other site
526218009286	hexamer interface [polypeptide binding]; other site
526218009287	metal binding site [ion binding]; metal-binding site
526218009288	BtpA family; Region: BtpA; cl00440
526218009289	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
526218009290	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
526218009291	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
526218009292	active site
526218009293	P-loop; other site
526218009294	phosphorylation site [posttranslational modification]
526218009295	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
526218009296	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
526218009297	oligomer interface [polypeptide binding]; other site
526218009298	active site
526218009299	metal binding site [ion binding]; metal-binding site
526218009300	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218009301	active site
526218009302	phosphorylation site [posttranslational modification]
526218009303	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
526218009304	PRD domain; Region: PRD; pfam00874
526218009305	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
526218009306	active site
526218009307	P-loop; other site
526218009308	phosphorylation site [posttranslational modification]
526218009309	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
526218009310	active site
526218009311	phosphorylation site [posttranslational modification]
526218009312	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048
526218009313	RNAase interaction site [polypeptide binding]; other site
526218009314	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
526218009315	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218009316	active site
526218009317	phosphorylation site [posttranslational modification]
526218009318	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
526218009319	active site
526218009320	P-loop; other site
526218009321	phosphorylation site [posttranslational modification]
526218009322	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
526218009323	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
526218009324	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
526218009325	putative substrate binding site [chemical binding]; other site
526218009326	putative ATP binding site [chemical binding]; other site
526218009327	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
526218009328	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
526218009329	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
526218009330	Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276
526218009331	putative active site [active]
526218009332	Flavodoxin domain; Region: Flavodoxin_5; cl17428
526218009333	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
526218009334	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
526218009335	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
526218009336	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
526218009337	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
526218009338	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
526218009339	TPP-binding site [chemical binding]; other site
526218009340	dimer interface [polypeptide binding]; other site
526218009341	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
526218009342	PYR/PP interface [polypeptide binding]; other site
526218009343	dimer interface [polypeptide binding]; other site
526218009344	TPP binding site [chemical binding]; other site
526218009345	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
526218009346	Glucitol operon activator protein (GutM); Region: GutM; pfam06923
526218009347	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
526218009348	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
526218009349	DNA binding residues [nucleotide binding]
526218009350	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
526218009351	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
526218009352	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
526218009353	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
526218009354	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
526218009355	E3 interaction surface; other site
526218009356	lipoyl attachment site [posttranslational modification]; other site
526218009357	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
526218009358	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
526218009359	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
526218009360	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
526218009361	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
526218009362	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
526218009363	E3 interaction surface; other site
526218009364	lipoyl attachment site [posttranslational modification]; other site
526218009365	e3 binding domain; Region: E3_binding; pfam02817
526218009366	e3 binding domain; Region: E3_binding; pfam02817
526218009367	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
526218009368	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
526218009369	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
526218009370	alpha subunit interface [polypeptide binding]; other site
526218009371	TPP binding site [chemical binding]; other site
526218009372	heterodimer interface [polypeptide binding]; other site
526218009373	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
526218009374	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
526218009375	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
526218009376	tetramer interface [polypeptide binding]; other site
526218009377	TPP-binding site [chemical binding]; other site
526218009378	heterodimer interface [polypeptide binding]; other site
526218009379	phosphorylation loop region [posttranslational modification]
526218009380	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516
526218009381	Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732
526218009382	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
526218009383	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
526218009384	PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608
526218009385	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
526218009386	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
526218009387	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
526218009388	histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856
526218009389	active site
526218009390	putative hydrolase; Validated; Region: PRK09248
526218009391	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
526218009392	active site
526218009393	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
526218009394	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
526218009395	dimer interface [polypeptide binding]; other site
526218009396	active site
526218009397	metal binding site [ion binding]; metal-binding site
526218009398	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
526218009399	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
526218009400	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
526218009401	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
526218009402	rhamnulose-1-phosphate aldolase; Provisional; Region: PRK03634
526218009403	intersubunit interface [polypeptide binding]; other site
526218009404	active site
526218009405	Zn2+ binding site [ion binding]; other site
526218009406	Domain of unknown function (DUF718); Region: DUF718; cl01281
526218009407	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
526218009408	L-rhamnose isomerase; Provisional; Region: PRK01076
526218009409	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
526218009410	N- and C-terminal domain interface [polypeptide binding]; other site
526218009411	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
526218009412	active site
526218009413	putative catalytic site [active]
526218009414	metal binding site [ion binding]; metal-binding site
526218009415	ATP binding site [chemical binding]; other site
526218009416	carbohydrate binding site [chemical binding]; other site
526218009417	Transcriptional regulators [Transcription]; Region: PurR; COG1609
526218009418	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
526218009419	DNA binding site [nucleotide binding]
526218009420	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
526218009421	dimerization interface [polypeptide binding]; other site
526218009422	ligand binding site [chemical binding]; other site
526218009423	flavodoxin; Provisional; Region: PRK07116
526218009424	Uncharacterized conserved protein [Function unknown]; Region: COG4925
526218009425	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
526218009426	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
526218009427	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
526218009428	histidinol-phosphate aminotransferase; Provisional; Region: PRK04870
526218009429	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
526218009430	transcription termination factor Rho; Provisional; Region: rho; PRK09376
526218009431	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
526218009432	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
526218009433	RNA binding site [nucleotide binding]; other site
526218009434	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
526218009435	Walker A motif; other site
526218009436	ATP binding site [chemical binding]; other site
526218009437	Walker B motif; other site
526218009438	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
526218009439	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
526218009440	active site
526218009441	catalytic site [active]
526218009442	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328
526218009443	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
526218009444	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526218009445	FeS/SAM binding site; other site
526218009446	TRAM domain; Region: TRAM; pfam01938
526218009447	Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693
526218009448	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
526218009449	metal binding site 2 [ion binding]; metal-binding site
526218009450	putative DNA binding helix; other site
526218009451	dimer interface [polypeptide binding]; other site
526218009452	structural Zn2+ binding site [ion binding]; other site
526218009453	metal binding site 1 [ion binding]; metal-binding site
526218009454	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
526218009455	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
526218009456	intersubunit interface [polypeptide binding]; other site
526218009457	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
526218009458	ABC transporter; Region: ABC_tran; pfam00005
526218009459	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
526218009460	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
526218009461	ABC-ATPase subunit  interface; other site
526218009462	dimer interface [polypeptide binding]; other site
526218009463	Ferritin-like domain; Region: Ferritin; pfam00210
526218009464	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
526218009465	dimerization interface [polypeptide binding]; other site
526218009466	DPS ferroxidase diiron center [ion binding]; other site
526218009467	ion pore; other site
526218009468	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
526218009469	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
526218009470	active site
526218009471	catalytic tetrad [active]
526218009472	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
526218009473	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
526218009474	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
526218009475	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
526218009476	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
526218009477	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
526218009478	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
526218009479	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
526218009480	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4727
526218009481	Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916
526218009482	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
526218009483	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
526218009484	active site
526218009485	HIGH motif; other site
526218009486	dimer interface [polypeptide binding]; other site
526218009487	KMSKS motif; other site
526218009488	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
526218009489	RNA binding surface [nucleotide binding]; other site
526218009490	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
526218009491	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
526218009492	putative substrate binding site [chemical binding]; other site
526218009493	putative ATP binding site [chemical binding]; other site
526218009494	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
526218009495	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
526218009496	dimer interface [polypeptide binding]; other site
526218009497	active site
526218009498	metal binding site [ion binding]; metal-binding site
526218009499	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
526218009500	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
526218009501	DNA binding residues [nucleotide binding]
526218009502	drug binding residues [chemical binding]; other site
526218009503	dimer interface [polypeptide binding]; other site
526218009504	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
526218009505	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526218009506	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
526218009507	Coenzyme A binding pocket [chemical binding]; other site
526218009508	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
526218009509	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
526218009510	dimerization interface 3.5A [polypeptide binding]; other site
526218009511	active site
526218009512	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
526218009513	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
526218009514	active site
526218009515	dimer interface [polypeptide binding]; other site
526218009516	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
526218009517	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
526218009518	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
526218009519	DNA binding residues [nucleotide binding]
526218009520	drug binding residues [chemical binding]; other site
526218009521	dimer interface [polypeptide binding]; other site
526218009522	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
526218009523	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
526218009524	homodimer interaction site [polypeptide binding]; other site
526218009525	cofactor binding site; other site
526218009526	PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
526218009527	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
526218009528	active site turn [active]
526218009529	phosphorylation site [posttranslational modification]
526218009530	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
526218009531	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
526218009532	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
526218009533	putative active site [active]
526218009534	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
526218009535	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
526218009536	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
526218009537	active site
526218009538	P-loop; other site
526218009539	phosphorylation site [posttranslational modification]
526218009540	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
526218009541	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
526218009542	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
526218009543	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
526218009544	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
526218009545	tetramer interface [polypeptide binding]; other site
526218009546	active site
526218009547	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
526218009548	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
526218009549	substrate binding site [chemical binding]; other site
526218009550	hexamer interface [polypeptide binding]; other site
526218009551	metal binding site [ion binding]; metal-binding site
526218009552	DKNYY family; Region: DKNYY; pfam13644
526218009553	Putative cyclase; Region: Cyclase; cl00814
526218009554	Uncharacterized conserved protein [Function unknown]; Region: COG3589
526218009555	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
526218009556	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
526218009557	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
526218009558	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
526218009559	putative active site [active]
526218009560	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
526218009561	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
526218009562	peptide binding site [polypeptide binding]; other site
526218009563	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
526218009564	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
526218009565	peptide binding site [polypeptide binding]; other site
526218009566	Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848
526218009567	catalytic triad [active]
526218009568	putative active site [active]
526218009569	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
526218009570	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218009571	Right handed beta helix region; Region: Beta_helix; pfam13229
526218009572	Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625
526218009573	Autotransporter beta-domain; Region: Autotransporter; smart00869
526218009574	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
526218009575	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526218009576	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
526218009577	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
526218009578	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
526218009579	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526218009580	Walker A/P-loop; other site
526218009581	ATP binding site [chemical binding]; other site
526218009582	Q-loop/lid; other site
526218009583	ABC transporter signature motif; other site
526218009584	Walker B; other site
526218009585	D-loop; other site
526218009586	H-loop/switch region; other site
526218009587	ABC-2 type transporter; Region: ABC2_membrane; cl17235
526218009588	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
526218009589	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
526218009590	peptide binding site [polypeptide binding]; other site
526218009591	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
526218009592	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
526218009593	peptide binding site [polypeptide binding]; other site
526218009594	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
526218009595	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
526218009596	peptide binding site [polypeptide binding]; other site
526218009597	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
526218009598	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
526218009599	Walker A/P-loop; other site
526218009600	ATP binding site [chemical binding]; other site
526218009601	Q-loop/lid; other site
526218009602	ABC transporter signature motif; other site
526218009603	Walker B; other site
526218009604	D-loop; other site
526218009605	H-loop/switch region; other site
526218009606	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
526218009607	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
526218009608	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
526218009609	Walker A/P-loop; other site
526218009610	ATP binding site [chemical binding]; other site
526218009611	Q-loop/lid; other site
526218009612	ABC transporter signature motif; other site
526218009613	Walker B; other site
526218009614	D-loop; other site
526218009615	H-loop/switch region; other site
526218009616	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
526218009617	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
526218009618	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
526218009619	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526218009620	dimer interface [polypeptide binding]; other site
526218009621	conserved gate region; other site
526218009622	putative PBP binding loops; other site
526218009623	ABC-ATPase subunit interface; other site
526218009624	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
526218009625	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526218009626	dimer interface [polypeptide binding]; other site
526218009627	conserved gate region; other site
526218009628	putative PBP binding loops; other site
526218009629	ABC-ATPase subunit interface; other site
526218009630	Autotransporter beta-domain; Region: Autotransporter; smart00869
526218009631	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
526218009632	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
526218009633	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
526218009634	active site
526218009635	phosphorylation site [posttranslational modification]
526218009636	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
526218009637	active pocket/dimerization site; other site
526218009638	active site
526218009639	phosphorylation site [posttranslational modification]
526218009640	Protein of unknown function (DUF1341); Region: DUF1341; cl06211
526218009641	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
526218009642	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
526218009643	catalytic residue [active]
526218009644	Initiator Replication protein; Region: Rep_3; pfam01051
526218009645	Protein of unknown function (DUF1634); Region: DUF1634; pfam07843
526218009646	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
526218009647	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
526218009648	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
526218009649	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
526218009650	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
526218009651	NAD binding site [chemical binding]; other site
526218009652	sugar binding site [chemical binding]; other site
526218009653	divalent metal binding site [ion binding]; other site
526218009654	tetramer (dimer of dimers) interface [polypeptide binding]; other site
526218009655	dimer interface [polypeptide binding]; other site
526218009656	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
526218009657	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
526218009658	active site
526218009659	trimer interface [polypeptide binding]; other site
526218009660	allosteric site; other site
526218009661	active site lid [active]
526218009662	hexamer (dimer of trimers) interface [polypeptide binding]; other site
526218009663	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
526218009664	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526218009665	DNA-binding site [nucleotide binding]; DNA binding site
526218009666	UTRA domain; Region: UTRA; pfam07702
526218009667	DJ-1 family protein; Region: not_thiJ; TIGR01383
526218009668	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
526218009669	conserved cys residue [active]
526218009670	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
526218009671	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
526218009672	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
526218009673	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
526218009674	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
526218009675	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
526218009676	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
526218009677	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
526218009678	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
526218009679	haemagglutination activity domain; Region: Haemagg_act; pfam05860
526218009680	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
526218009681	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
526218009682	Holin family; Region: Phage_holin_4; pfam05105
526218009683	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
526218009684	active site
526218009685	metal binding site [ion binding]; metal-binding site
526218009686	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
526218009687	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
526218009688	Protein of unknown function (DUF935); Region: DUF935; pfam06074
526218009689	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
526218009690	DNA primase (bacterial type) [DNA replication, recombination, and repair]; Region: DnaG; COG0358
526218009691	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
526218009692	active site
526218009693	metal binding site [ion binding]; metal-binding site
526218009694	interdomain interaction site; other site
526218009695	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
526218009696	AAA domain; Region: AAA_25; pfam13481
526218009697	Walker A motif; other site
526218009698	ATP binding site [chemical binding]; other site
526218009699	Walker B motif; other site
526218009700	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
526218009701	BRO family, N-terminal domain; Region: Bro-N; pfam02498
526218009702	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526218009703	non-specific DNA binding site [nucleotide binding]; other site
526218009704	salt bridge; other site
526218009705	sequence-specific DNA binding site [nucleotide binding]; other site
526218009706	Domain of unknown function (DUF955); Region: DUF955; pfam06114
526218009707	Excalibur calcium-binding domain; Region: Excalibur; smart00894
526218009708	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526218009709	non-specific DNA binding site [nucleotide binding]; other site
526218009710	salt bridge; other site
526218009711	sequence-specific DNA binding site [nucleotide binding]; other site
526218009712	Predicted transcriptional regulator [Transcription]; Region: COG2932
526218009713	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
526218009714	Catalytic site [active]
526218009715	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
526218009716	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
526218009717	active site
526218009718	catalytic residues [active]
526218009719	DNA binding site [nucleotide binding]
526218009720	Int/Topo IB signature motif; other site
526218009721	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
526218009722	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
526218009723	ligand binding site [chemical binding]; other site
526218009724	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
526218009725	DALR anticodon binding domain; Region: DALR_1; pfam05746
526218009726	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
526218009727	dimer interface [polypeptide binding]; other site
526218009728	motif 1; other site
526218009729	active site
526218009730	motif 2; other site
526218009731	motif 3; other site
526218009732	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
526218009733	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
526218009734	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
526218009735	HIGH motif; other site
526218009736	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
526218009737	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
526218009738	active site
526218009739	KMSKS motif; other site
526218009740	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
526218009741	tRNA binding surface [nucleotide binding]; other site
526218009742	anticodon binding site; other site
526218009743	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
526218009744	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
526218009745	L-lactate permease; Region: Lactate_perm; cl00701
526218009746	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
526218009747	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
526218009748	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
526218009749	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
526218009750	RNA binding site [nucleotide binding]; other site
526218009751	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
526218009752	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526218009753	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526218009754	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
526218009755	active site
526218009756	motif I; other site
526218009757	motif II; other site
526218009758	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
526218009759	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
526218009760	hybrid cluster protein; Provisional; Region: PRK05290
526218009761	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
526218009762	ACS interaction site; other site
526218009763	CODH interaction site; other site
526218009764	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
526218009765	hybrid metal cluster; other site
526218009766	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
526218009767	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
526218009768	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
526218009769	methionine sulfoxide reductase B; Provisional; Region: PRK00222
526218009770	SelR domain; Region: SelR; pfam01641
526218009771	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
526218009772	Autotransporter beta-domain; Region: Autotransporter; smart00869
526218009773	alpha-mannosidase; Provisional; Region: PRK09819
526218009774	N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815
526218009775	active site
526218009776	metal binding site [ion binding]; metal-binding site
526218009777	catalytic site [active]
526218009778	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
526218009779	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
526218009780	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
526218009781	active site
526218009782	P-loop; other site
526218009783	phosphorylation site [posttranslational modification]
526218009784	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218009785	active site
526218009786	phosphorylation site [posttranslational modification]
526218009787	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
526218009788	Mga helix-turn-helix domain; Region: Mga; pfam05043
526218009789	PRD domain; Region: PRD; pfam00874
526218009790	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
526218009791	active site
526218009792	P-loop; other site
526218009793	phosphorylation site [posttranslational modification]
526218009794	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526218009795	active site
526218009796	phosphorylation site [posttranslational modification]
526218009797	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
526218009798	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
526218009799	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
526218009800	Zn2+ binding site [ion binding]; other site
526218009801	Mg2+ binding site [ion binding]; other site
526218009802	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
526218009803	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
526218009804	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
526218009805	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
526218009806	alphaNTD homodimer interface [polypeptide binding]; other site
526218009807	alphaNTD - beta interaction site [polypeptide binding]; other site
526218009808	alphaNTD - beta' interaction site [polypeptide binding]; other site
526218009809	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
526218009810	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
526218009811	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
526218009812	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
526218009813	RNA binding surface [nucleotide binding]; other site
526218009814	30S ribosomal protein S11; Validated; Region: PRK05309
526218009815	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
526218009816	30S ribosomal protein S13; Region: bact_S13; TIGR03631
526218009817	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
526218009818	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
526218009819	rRNA binding site [nucleotide binding]; other site
526218009820	predicted 30S ribosome binding site; other site
526218009821	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
526218009822	active site
526218009823	adenylate kinase; Reviewed; Region: adk; PRK00279
526218009824	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
526218009825	AMP-binding site [chemical binding]; other site
526218009826	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
526218009827	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
526218009828	SecY translocase; Region: SecY; pfam00344
526218009829	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
526218009830	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
526218009831	23S rRNA binding site [nucleotide binding]; other site
526218009832	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
526218009833	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
526218009834	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
526218009835	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
526218009836	23S rRNA interface [nucleotide binding]; other site
526218009837	L21e interface [polypeptide binding]; other site
526218009838	5S rRNA interface [nucleotide binding]; other site
526218009839	L27 interface [polypeptide binding]; other site
526218009840	L5 interface [polypeptide binding]; other site
526218009841	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
526218009842	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
526218009843	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
526218009844	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
526218009845	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
526218009846	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
526218009847	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
526218009848	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
526218009849	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
526218009850	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
526218009851	RNA binding site [nucleotide binding]; other site
526218009852	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
526218009853	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
526218009854	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
526218009855	23S rRNA interface [nucleotide binding]; other site
526218009856	putative translocon interaction site; other site
526218009857	signal recognition particle (SRP54) interaction site; other site
526218009858	L23 interface [polypeptide binding]; other site
526218009859	trigger factor interaction site; other site
526218009860	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
526218009861	23S rRNA interface [nucleotide binding]; other site
526218009862	5S rRNA interface [nucleotide binding]; other site
526218009863	putative antibiotic binding site [chemical binding]; other site
526218009864	L25 interface [polypeptide binding]; other site
526218009865	L27 interface [polypeptide binding]; other site
526218009866	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
526218009867	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
526218009868	G-X-X-G motif; other site
526218009869	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
526218009870	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
526218009871	putative translocon binding site; other site
526218009872	protein-rRNA interface [nucleotide binding]; other site
526218009873	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
526218009874	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
526218009875	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
526218009876	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
526218009877	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
526218009878	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
526218009879	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
526218009880	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
526218009881	elongation factor Tu; Reviewed; Region: PRK00049
526218009882	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
526218009883	G1 box; other site
526218009884	GEF interaction site [polypeptide binding]; other site
526218009885	GTP/Mg2+ binding site [chemical binding]; other site
526218009886	Switch I region; other site
526218009887	G2 box; other site
526218009888	G3 box; other site
526218009889	Switch II region; other site
526218009890	G4 box; other site
526218009891	G5 box; other site
526218009892	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
526218009893	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
526218009894	Antibiotic Binding Site [chemical binding]; other site
526218009895	elongation factor G; Reviewed; Region: PRK00007
526218009896	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
526218009897	G1 box; other site
526218009898	putative GEF interaction site [polypeptide binding]; other site
526218009899	GTP/Mg2+ binding site [chemical binding]; other site
526218009900	Switch I region; other site
526218009901	G2 box; other site
526218009902	G3 box; other site
526218009903	Switch II region; other site
526218009904	G4 box; other site
526218009905	G5 box; other site
526218009906	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
526218009907	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
526218009908	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
526218009909	30S ribosomal protein S7; Validated; Region: PRK05302
526218009910	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
526218009911	S17 interaction site [polypeptide binding]; other site
526218009912	S8 interaction site; other site
526218009913	16S rRNA interaction site [nucleotide binding]; other site
526218009914	streptomycin interaction site [chemical binding]; other site
526218009915	23S rRNA interaction site [nucleotide binding]; other site
526218009916	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
526218009917	Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699
526218009918	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
526218009919	metal ion-dependent adhesion site (MIDAS); other site
526218009920	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526218009921	binding surface
526218009922	TPR motif; other site
526218009923	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
526218009924	aspartate racemase; Region: asp_race; TIGR00035
526218009925	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
526218009926	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
526218009927	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
526218009928	ABC transporter; Region: ABC_tran_2; pfam12848
526218009929	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
526218009930	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
526218009931	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526218009932	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
526218009933	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
526218009934	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
526218009935	TM-ABC transporter signature motif; other site
526218009936	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
526218009937	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526218009938	Walker A/P-loop; other site
526218009939	ATP binding site [chemical binding]; other site
526218009940	Q-loop/lid; other site
526218009941	ABC transporter signature motif; other site
526218009942	Walker B; other site
526218009943	D-loop; other site
526218009944	H-loop/switch region; other site
526218009945	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
526218009946	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
526218009947	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
526218009948	putative ligand binding site [chemical binding]; other site
526218009949	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
526218009950	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
526218009951	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
526218009952	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
526218009953	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
526218009954	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526218009955	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
526218009956	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
526218009957	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
526218009958	PYR/PP interface [polypeptide binding]; other site
526218009959	dimer interface [polypeptide binding]; other site
526218009960	TPP binding site [chemical binding]; other site
526218009961	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
526218009962	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
526218009963	TPP-binding site; other site
526218009964	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
526218009965	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
526218009966	tetrameric interface [polypeptide binding]; other site
526218009967	NAD binding site [chemical binding]; other site
526218009968	catalytic residues [active]
526218009969	KduI/IolB family; Region: KduI; pfam04962
526218009970	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
526218009971	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
526218009972	substrate binding site [chemical binding]; other site
526218009973	ATP binding site [chemical binding]; other site
526218009974	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
526218009975	intersubunit interface [polypeptide binding]; other site
526218009976	active site
526218009977	zinc binding site [ion binding]; other site
526218009978	Na+ binding site [ion binding]; other site
526218009979	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
526218009980	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
526218009981	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
526218009982	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
526218009983	substrate binding site [chemical binding]; other site
526218009984	Predicted integral membrane protein [Function unknown]; Region: COG5658
526218009985	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
526218009986	SdpI/YhfL protein family; Region: SdpI; pfam13630
526218009987	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526218009988	dimerization interface [polypeptide binding]; other site
526218009989	putative DNA binding site [nucleotide binding]; other site
526218009990	putative Zn2+ binding site [ion binding]; other site
526218009991	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
526218009992	Transposase; Region: HTH_Tnp_1; cl17663
526218009993	haemagglutination activity domain; Region: Haemagg_act; pfam05860
526218009994	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
526218009995	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
526218009996	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
526218009997	Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436
526218009998	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
526218009999	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
526218010000	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
526218010001	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
526218010002	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
526218010003	active site
526218010004	metal binding site [ion binding]; metal-binding site
526218010005	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
526218010006	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
526218010007	Adhesion protein FadA; Region: FadA; pfam09403
526218010008	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218010009	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
526218010010	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526218010011	dimer interface [polypeptide binding]; other site
526218010012	conserved gate region; other site
526218010013	putative PBP binding loops; other site
526218010014	ABC-ATPase subunit interface; other site
526218010015	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
526218010016	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526218010017	dimer interface [polypeptide binding]; other site
526218010018	conserved gate region; other site
526218010019	ABC-ATPase subunit interface; other site
526218010020	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
526218010021	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
526218010022	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
526218010023	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
526218010024	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
526218010025	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
526218010026	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
526218010027	DKNYY family; Region: DKNYY; pfam13644
526218010028	DKNYY family; Region: DKNYY; pfam13644
526218010029	DKNYY family; Region: DKNYY; pfam13644
526218010030	DKNYY family; Region: DKNYY; pfam13644
526218010031	DKNYY family; Region: DKNYY; pfam13644
526218010032	DKNYY family; Region: DKNYY; pfam13644
526218010033	DKNYY family; Region: DKNYY; pfam13644
526218010034	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
526218010035	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
526218010036	D-mannonate oxidoreductase; Provisional; Region: PRK08277
526218010037	putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935
526218010038	putative NAD(P) binding site [chemical binding]; other site
526218010039	active site
526218010040	mannonate dehydratase; Provisional; Region: PRK03906
526218010041	mannonate dehydratase; Region: uxuA; TIGR00695
526218010042	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
526218010043	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526218010044	dimer interface [polypeptide binding]; other site
526218010045	conserved gate region; other site
526218010046	putative PBP binding loops; other site
526218010047	ABC-ATPase subunit interface; other site
526218010048	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
526218010049	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526218010050	dimer interface [polypeptide binding]; other site
526218010051	conserved gate region; other site
526218010052	putative PBP binding loops; other site
526218010053	ABC-ATPase subunit interface; other site
526218010054	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
526218010055	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
526218010056	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
526218010057	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
526218010058	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
526218010059	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526218010060	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
526218010061	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
526218010062	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526218010063	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
526218010064	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
526218010065	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526218010066	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
526218010067	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
526218010068	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
526218010069	Walker A/P-loop; other site
526218010070	ATP binding site [chemical binding]; other site
526218010071	Q-loop/lid; other site
526218010072	ABC transporter signature motif; other site
526218010073	Walker B; other site
526218010074	D-loop; other site
526218010075	H-loop/switch region; other site
526218010076	TOBE domain; Region: TOBE; pfam03459
526218010077	Transcriptional regulators [Transcription]; Region: GntR; COG1802
526218010078	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526218010079	DNA-binding site [nucleotide binding]; DNA binding site
526218010080	FCD domain; Region: FCD; pfam07729
526218010081	Transcriptional regulators [Transcription]; Region: GntR; COG1802
526218010082	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526218010083	DNA-binding site [nucleotide binding]; DNA binding site
526218010084	FCD domain; Region: FCD; pfam07729
526218010085	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
526218010086	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
526218010087	substrate binding site [chemical binding]; other site
526218010088	ATP binding site [chemical binding]; other site
526218010089	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
526218010090	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
526218010091	active site
526218010092	intersubunit interface [polypeptide binding]; other site
526218010093	catalytic residue [active]
526218010094	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
526218010095	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
526218010096	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
526218010097	HlyD family secretion protein; Region: HlyD_3; pfam13437
526218010098	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526218010099	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
526218010100	Walker A/P-loop; other site
526218010101	ATP binding site [chemical binding]; other site
526218010102	Q-loop/lid; other site
526218010103	ABC transporter signature motif; other site
526218010104	Walker B; other site
526218010105	D-loop; other site
526218010106	H-loop/switch region; other site
526218010107	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526218010108	Walker A/P-loop; other site
526218010109	ATP binding site [chemical binding]; other site
526218010110	Q-loop/lid; other site
526218010111	ABC transporter signature motif; other site
526218010112	Walker B; other site
526218010113	D-loop; other site
526218010114	H-loop/switch region; other site
526218010115	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
526218010116	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
526218010117	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
526218010118	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
526218010119	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
526218010120	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526218010121	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526218010122	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
526218010123	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
526218010124	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
526218010125	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
526218010126	enolase; Provisional; Region: eno; PRK00077
526218010127	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
526218010128	dimer interface [polypeptide binding]; other site
526218010129	metal binding site [ion binding]; metal-binding site
526218010130	substrate binding pocket [chemical binding]; other site
526218010131	SurA N-terminal domain; Region: SurA_N_3; cl07813
526218010132	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
526218010133	Rubredoxin [Energy production and conversion]; Region: COG1773
526218010134	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
526218010135	iron binding site [ion binding]; other site
526218010136	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
526218010137	Ferritin-like domain; Region: Ferritin; pfam00210
526218010138	ferroxidase diiron center [ion binding]; other site
526218010139	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
526218010140	metal binding site 2 [ion binding]; metal-binding site
526218010141	putative DNA binding helix; other site
526218010142	metal binding site 1 [ion binding]; metal-binding site
526218010143	dimer interface [polypeptide binding]; other site
526218010144	structural Zn2+ binding site [ion binding]; other site
526218010145	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
526218010146	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
526218010147	DHH family; Region: DHH; pfam01368
526218010148	DHHA1 domain; Region: DHHA1; pfam02272
526218010149	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
526218010150	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
526218010151	active site turn [active]
526218010152	phosphorylation site [posttranslational modification]
526218010153	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
526218010154	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
526218010155	beta-galactosidase; Region: BGL; TIGR03356
526218010156	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
526218010157	HTH domain; Region: HTH_11; pfam08279
526218010158	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
526218010159	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426
526218010160	NADP+ binding site [chemical binding]; other site
526218010161	RibD C-terminal domain; Region: RibD_C; cl17279
526218010162	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
526218010163	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526218010164	dimer interface [polypeptide binding]; other site
526218010165	conserved gate region; other site
526218010166	putative PBP binding loops; other site
526218010167	ABC-ATPase subunit interface; other site
526218010168	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526218010169	dimer interface [polypeptide binding]; other site
526218010170	conserved gate region; other site
526218010171	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526218010172	putative PBP binding loops; other site
526218010173	ABC-ATPase subunit interface; other site
526218010174	PBP superfamily domain; Region: PBP_like_2; cl17296
526218010175	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
526218010176	Predicted membrane protein [Function unknown]; Region: COG2323
526218010177	Predicted integral membrane protein [Function unknown]; Region: COG5505
526218010178	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
526218010179	coproporphyrinogen III oxidase; Provisional; Region: PRK08207
526218010180	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526218010181	FeS/SAM binding site; other site
526218010182	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
526218010183	Protein of unknown function (DUF4240); Region: DUF4240; pfam14024
526218010184	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
526218010185	Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539
526218010186	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
526218010187	RNA binding site [nucleotide binding]; other site
526218010188	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
526218010189	RNA binding site [nucleotide binding]; other site
526218010190	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
526218010191	RNA binding site [nucleotide binding]; other site
526218010192	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
526218010193	RNA binding site [nucleotide binding]; other site
526218010194	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164
526218010195	RNA binding site [nucleotide binding]; other site
526218010196	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
526218010197	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
526218010198	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
526218010199	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
526218010200	dimerization domain swap beta strand [polypeptide binding]; other site
526218010201	regulatory protein interface [polypeptide binding]; other site
526218010202	active site
526218010203	regulatory phosphorylation site [posttranslational modification]; other site
526218010204	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
526218010205	beta-galactosidase; Region: BGL; TIGR03356
526218010206	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
526218010207	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
526218010208	putative tRNA-binding site [nucleotide binding]; other site
526218010209	B3/4 domain; Region: B3_4; pfam03483
526218010210	tRNA synthetase B5 domain; Region: B5; smart00874
526218010211	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
526218010212	dimer interface [polypeptide binding]; other site
526218010213	motif 1; other site
526218010214	motif 3; other site
526218010215	motif 2; other site
526218010216	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
526218010217	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
526218010218	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
526218010219	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
526218010220	dimer interface [polypeptide binding]; other site
526218010221	motif 1; other site
526218010222	active site
526218010223	motif 2; other site
526218010224	motif 3; other site
526218010225	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829
526218010226	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218010227	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
526218010228	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526218010229	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
526218010230	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
526218010231	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
526218010232	DNA binding residues [nucleotide binding]
526218010233	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
526218010234	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
526218010235	MgtC family; Region: MgtC; pfam02308
526218010236	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
526218010237	bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110
526218010238	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
526218010239	active site turn [active]
526218010240	phosphorylation site [posttranslational modification]
526218010241	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
526218010242	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
526218010243	active site
526218010244	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
526218010245	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
526218010246	NAD(P) binding site [chemical binding]; other site
526218010247	LDH/MDH dimer interface [polypeptide binding]; other site
526218010248	substrate binding site [chemical binding]; other site
526218010249	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
526218010250	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
526218010251	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
526218010252	putative active site [active]
526218010253	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
526218010254	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
526218010255	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
526218010256	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
526218010257	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
526218010258	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
526218010259	P-loop; other site
526218010260	Magnesium ion binding site [ion binding]; other site
526218010261	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
526218010262	Magnesium ion binding site [ion binding]; other site
526218010263	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
526218010264	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
526218010265	catalytic loop [active]
526218010266	iron binding site [ion binding]; other site
526218010267	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
526218010268	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
526218010269	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
526218010270	[4Fe-4S] binding site [ion binding]; other site
526218010271	molybdopterin cofactor binding site; other site
526218010272	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
526218010273	molybdopterin cofactor binding site; other site
526218010274	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
526218010275	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
526218010276	GTP binding site; other site
526218010277	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
526218010278	Domain of unknown function (DUF1848); Region: DUF1848; pfam08902
526218010279	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
526218010280	endonuclease III; Region: ENDO3c; smart00478
526218010281	minor groove reading motif; other site
526218010282	helix-hairpin-helix signature motif; other site
526218010283	substrate binding pocket [chemical binding]; other site
526218010284	active site
526218010285	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
526218010286	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
526218010287	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
526218010288	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
526218010289	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
526218010290	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
526218010291	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
526218010292	Thiamine pyrophosphokinase; Region: TPK; cd07995
526218010293	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
526218010294	active site
526218010295	dimerization interface [polypeptide binding]; other site
526218010296	thiamine binding site [chemical binding]; other site
526218010297	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
526218010298	putative FMN binding site [chemical binding]; other site
526218010299	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
526218010300	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
526218010301	substrate binding site [chemical binding]; other site
526218010302	hexamer interface [polypeptide binding]; other site
526218010303	metal binding site [ion binding]; metal-binding site
526218010304	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
526218010305	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
526218010306	N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859
526218010307	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
526218010308	homodimer interface [polypeptide binding]; other site
526218010309	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
526218010310	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
526218010311	active site
526218010312	catalytic site [active]
526218010313	M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659
526218010314	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
526218010315	oligomer interface [polypeptide binding]; other site
526218010316	putative active site [active]
526218010317	metal binding site [ion binding]; metal-binding site
526218010318	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
526218010319	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
526218010320	active site
526218010321	dimer interface [polypeptide binding]; other site
526218010322	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
526218010323	dimer interface [polypeptide binding]; other site
526218010324	active site
526218010325	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
526218010326	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
526218010327	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
526218010328	putative dimer interface [polypeptide binding]; other site
526218010329	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
526218010330	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
526218010331	trmE is a tRNA modification GTPase; Region: trmE; cd04164
526218010332	G1 box; other site
526218010333	GTP/Mg2+ binding site [chemical binding]; other site
526218010334	Switch I region; other site
526218010335	G2 box; other site
526218010336	Switch II region; other site
526218010337	G3 box; other site
526218010338	G4 box; other site
526218010339	G5 box; other site
526218010340	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
526218010341	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
526218010342	G-X-X-G motif; other site
526218010343	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
526218010344	RxxxH motif; other site
526218010345	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
526218010346	Haemolytic domain; Region: Haemolytic; pfam01809
526218010347	Ribonuclease P; Region: Ribonuclease_P; pfam00825
526218010348	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
526218010349	multiple promoter invertase; Provisional; Region: mpi; PRK13413
526218010350	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
526218010351	catalytic residues [active]
526218010352	catalytic nucleophile [active]
526218010353	Presynaptic Site I dimer interface [polypeptide binding]; other site
526218010354	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
526218010355	Synaptic Flat tetramer interface [polypeptide binding]; other site
526218010356	Synaptic Site I dimer interface [polypeptide binding]; other site
526218010357	Domain of unknown function (DUF4263); Region: DUF4263; pfam14082
526218010358	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446
526218010359	GIY-YIG motif/motif A; other site
526218010360	putative active site [active]
526218010361	putative metal binding site [ion binding]; other site
526218010362	V-type ATP synthase subunit I; Validated; Region: PRK05771
526218010363	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
526218010364	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
526218010365	P-loop; other site
526218010366	Magnesium ion binding site [ion binding]; other site
526218010367	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
526218010368	Magnesium ion binding site [ion binding]; other site
526218010369	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
526218010370	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
526218010371	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
526218010372	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
526218010373	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
526218010374	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
526218010375	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
526218010376	P-loop; other site
526218010377	Magnesium ion binding site [ion binding]; other site
526218010378	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
526218010379	Magnesium ion binding site [ion binding]; other site
526218010380	Replication initiator protein A; Region: RPA; cl17860
526218010381	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
526218010382	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
526218010383	Initiator Replication protein; Region: Rep_3; pfam01051
526218010384	DNA topoisomerase III; Provisional; Region: PRK07726
526218010385	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
526218010386	active site
526218010387	putative interdomain interaction site [polypeptide binding]; other site
526218010388	putative metal-binding site [ion binding]; other site
526218010389	putative nucleotide binding site [chemical binding]; other site
526218010390	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986
526218010391	domain I; other site
526218010392	DNA binding groove [nucleotide binding]
526218010393	phosphate binding site [ion binding]; other site
526218010394	domain II; other site
526218010395	domain III; other site
526218010396	nucleotide binding site [chemical binding]; other site
526218010397	catalytic site [active]
526218010398	domain IV; other site
526218010399	Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406
526218010400	MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937
526218010401	YARHG domain; Region: YARHG; pfam13308
526218010402	PemK-like protein; Region: PemK; pfam02452
526218010403	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
526218010404	haemagglutination activity domain; Region: Haemagg_act; pfam05860
526218010405	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
526218010406	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
526218010407	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
526218010408	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
526218010409	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
526218010410	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
526218010411	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
526218010412	Protein of unknown function (DUF2185); Region: DUF2185; cl02019
526218010413	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526218010414	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526218010415	Autotransporter beta-domain; Region: Autotransporter; pfam03797
526218010416	Domain of unknown function (DUF4407); Region: DUF4407; pfam14362
526218010417	IncA protein; Region: IncA; pfam04156
526218010418	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
526218010419	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
526218010420	active site
526218010421	DNA binding site [nucleotide binding]
526218010422	Int/Topo IB signature motif; other site
526218010423	DNA primase, catalytic core; Region: dnaG; TIGR01391
526218010424	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
526218010425	active site
526218010426	metal binding site [ion binding]; metal-binding site
526218010427	interdomain interaction site; other site
526218010428	DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796
526218010429	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
526218010430	Walker A motif; other site
526218010431	ATP binding site [chemical binding]; other site
526218010432	Walker B motif; other site