-- dump date   	20140620_062134
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
546271000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
546271000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
546271000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546271000004	Walker A motif; other site
546271000005	ATP binding site [chemical binding]; other site
546271000006	Walker B motif; other site
546271000007	arginine finger; other site
546271000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
546271000009	DnaA box-binding interface [nucleotide binding]; other site
546271000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
546271000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
546271000012	putative DNA binding surface [nucleotide binding]; other site
546271000013	dimer interface [polypeptide binding]; other site
546271000014	beta-clamp/clamp loader binding surface; other site
546271000015	beta-clamp/translesion DNA polymerase binding surface; other site
546271000016	recombination protein F; Reviewed; Region: recF; PRK00064
546271000017	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
546271000018	Walker A/P-loop; other site
546271000019	ATP binding site [chemical binding]; other site
546271000020	Q-loop/lid; other site
546271000021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546271000022	ABC transporter signature motif; other site
546271000023	Walker B; other site
546271000024	D-loop; other site
546271000025	H-loop/switch region; other site
546271000026	Protein of unknown function (DUF721); Region: DUF721; pfam05258
546271000027	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
546271000028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546271000029	Mg2+ binding site [ion binding]; other site
546271000030	G-X-G motif; other site
546271000031	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
546271000032	anchoring element; other site
546271000033	dimer interface [polypeptide binding]; other site
546271000034	ATP binding site [chemical binding]; other site
546271000035	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
546271000036	active site
546271000037	putative metal-binding site [ion binding]; other site
546271000038	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
546271000039	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
546271000040	AAA domain; Region: AAA_14; pfam13173
546271000041	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
546271000042	active site
546271000043	active pocket/dimerization site; other site
546271000044	phosphorylation site [posttranslational modification]
546271000045	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
546271000046	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
546271000047	dimer interface [polypeptide binding]; other site
546271000048	active site
546271000049	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
546271000050	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546271000051	Walker A motif; other site
546271000052	ATP binding site [chemical binding]; other site
546271000053	Walker B motif; other site
546271000054	arginine finger; other site
546271000055	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
546271000056	hypothetical protein; Validated; Region: PRK00153
546271000057	recombination protein RecR; Reviewed; Region: recR; PRK00076
546271000058	RecR protein; Region: RecR; pfam02132
546271000059	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
546271000060	putative active site [active]
546271000061	putative metal-binding site [ion binding]; other site
546271000062	tetramer interface [polypeptide binding]; other site
546271000063	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546271000064	Major Facilitator Superfamily; Region: MFS_1; pfam07690
546271000065	putative substrate translocation pore; other site
546271000066	Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621
546271000067	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
546271000068	dimer interface [polypeptide binding]; other site
546271000069	substrate binding site [chemical binding]; other site
546271000070	ATP binding site [chemical binding]; other site
546271000071	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
546271000072	active site
546271000073	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
546271000074	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
546271000075	dimer interface [polypeptide binding]; other site
546271000076	active site
546271000077	glycine-pyridoxal phosphate binding site [chemical binding]; other site
546271000078	folate binding site [chemical binding]; other site
546271000079	exopolyphosphatase; Region: exo_poly_only; TIGR03706
546271000080	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
546271000081	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503
546271000082	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
546271000083	Peptidase family M23; Region: Peptidase_M23; pfam01551
546271000084	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
546271000085	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
546271000086	intersubunit interface [polypeptide binding]; other site
546271000087	active site
546271000088	catalytic residue [active]
546271000089	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
546271000090	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
546271000091	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
546271000092	FMN binding site [chemical binding]; other site
546271000093	dimer interface [polypeptide binding]; other site
546271000094	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
546271000095	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
546271000096	SLBB domain; Region: SLBB; pfam10531
546271000097	Chain length determinant protein; Region: Wzz; pfam02706
546271000098	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
546271000099	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
546271000100	Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022
546271000101	Bacterial sugar transferase; Region: Bac_transf; pfam02397
546271000102	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
546271000103	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
546271000104	active site
546271000105	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
546271000106	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
546271000107	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
546271000108	GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cd11296
546271000109	GDP-Fucose binding site [chemical binding]; other site
546271000110	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
546271000111	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
546271000112	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
546271000113	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
546271000114	NADP-binding site; other site
546271000115	homotetramer interface [polypeptide binding]; other site
546271000116	substrate binding site [chemical binding]; other site
546271000117	homodimer interface [polypeptide binding]; other site
546271000118	active site
546271000119	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
546271000120	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
546271000121	NADP-binding site; other site
546271000122	homotetramer interface [polypeptide binding]; other site
546271000123	substrate binding site [chemical binding]; other site
546271000124	homodimer interface [polypeptide binding]; other site
546271000125	active site
546271000126	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
546271000127	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
546271000128	NADP binding site [chemical binding]; other site
546271000129	active site
546271000130	putative substrate binding site [chemical binding]; other site
546271000131	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
546271000132	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546271000133	Walker A/P-loop; other site
546271000134	ATP binding site [chemical binding]; other site
546271000135	Q-loop/lid; other site
546271000136	ABC transporter signature motif; other site
546271000137	Walker B; other site
546271000138	D-loop; other site
546271000139	H-loop/switch region; other site
546271000140	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563
546271000141	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
546271000142	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
546271000143	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
546271000144	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
546271000145	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
546271000146	trimer interface [polypeptide binding]; other site
546271000147	active site
546271000148	substrate binding site [chemical binding]; other site
546271000149	CoA binding site [chemical binding]; other site
546271000150	UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589
546271000151	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
546271000152	NAD(P) binding site [chemical binding]; other site
546271000153	homodimer interface [polypeptide binding]; other site
546271000154	substrate binding site [chemical binding]; other site
546271000155	active site
546271000156	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
546271000157	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
546271000158	inhibitor-cofactor binding pocket; inhibition site
546271000159	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546271000160	catalytic residue [active]
546271000161	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
546271000162	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
546271000163	active site
546271000164	catalytic tetrad [active]
546271000165	SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518
546271000166	ligand binding site; other site
546271000167	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
546271000168	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
546271000169	inhibitor-cofactor binding pocket; inhibition site
546271000170	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546271000171	catalytic residue [active]
546271000172	pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590
546271000173	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
546271000174	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
546271000175	active site
546271000176	cosubstrate binding site; other site
546271000177	substrate binding site [chemical binding]; other site
546271000178	catalytic site [active]
546271000179	Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_1; cd08821
546271000180	putative active site [active]
546271000181	putative substrate binding site [chemical binding]; other site
546271000182	putative cosubstrate binding site; other site
546271000183	catalytic site [active]
546271000184	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
546271000185	pseudaminic acid synthase; Region: PseI; TIGR03586
546271000186	NeuB family; Region: NeuB; pfam03102
546271000187	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
546271000188	NeuB binding interface [polypeptide binding]; other site
546271000189	putative substrate binding site [chemical binding]; other site
546271000190	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
546271000191	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
546271000192	active site
546271000193	Cupin domain; Region: Cupin_2; cl17218
546271000194	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
546271000195	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
546271000196	putative active site [active]
546271000197	putative NTP binding site [chemical binding]; other site
546271000198	putative nucleic acid binding site [nucleotide binding]; other site
546271000199	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
546271000200	AAA domain; Region: AAA_21; pfam13304
546271000201	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546271000202	Walker B; other site
546271000203	D-loop; other site
546271000204	H-loop/switch region; other site
546271000205	RloB-like protein; Region: RloB; pfam13707
546271000206	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
546271000207	active site
546271000208	metal binding site [ion binding]; metal-binding site
546271000209	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041
546271000210	RelB antitoxin; Region: RelB; cl01171
546271000211	putative metal dependent hydrolase; Provisional; Region: PRK11598
546271000212	Sulfatase; Region: Sulfatase; pfam00884
546271000213	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
546271000214	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
546271000215	Peptidase family M48; Region: Peptidase_M48; cl12018
546271000216	TPR repeat; Region: TPR_11; pfam13414
546271000217	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546271000218	TPR motif; other site
546271000219	binding surface
546271000220	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
546271000221	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
546271000222	ligand binding site [chemical binding]; other site
546271000223	active site
546271000224	UGI interface [polypeptide binding]; other site
546271000225	catalytic site [active]
546271000226	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
546271000227	substrate binding pocket [chemical binding]; other site
546271000228	membrane-bound complex binding site; other site
546271000229	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
546271000230	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546271000231	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546271000232	metal binding site [ion binding]; metal-binding site
546271000233	active site
546271000234	I-site; other site
546271000235	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
546271000236	TPR repeat; Region: TPR_11; pfam13414
546271000237	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546271000238	binding surface
546271000239	TPR motif; other site
546271000240	TPR repeat; Region: TPR_11; pfam13414
546271000241	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
546271000242	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
546271000243	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
546271000244	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
546271000245	Surface antigen; Region: Bac_surface_Ag; pfam01103
546271000246	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
546271000247	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
546271000248	S-layer homology domain; Region: SLH; pfam00395
546271000249	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
546271000250	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
546271000251	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
546271000252	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
546271000253	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
546271000254	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
546271000255	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
546271000256	putative metal binding site [ion binding]; other site
546271000257	Tellurium resistance protein; Region: Tellurium_res; pfam10138
546271000258	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
546271000259	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
546271000260	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
546271000261	putative metal binding site [ion binding]; other site
546271000262	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
546271000263	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
546271000264	putative metal binding site [ion binding]; other site
546271000265	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
546271000266	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
546271000267	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
546271000268	putative metal binding site [ion binding]; other site
546271000269	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
546271000270	putative metal binding site [ion binding]; other site
546271000271	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
546271000272	ATP-grasp domain; Region: ATP-grasp_4; cl17255
546271000273	Protein of unknown function (DUF3706); Region: DUF3706; pfam12500
546271000274	Protein of unknown function (DUF2983); Region: DUF2983; pfam11202
546271000275	Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116
546271000276	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
546271000277	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
546271000278	phosphopentomutase; Provisional; Region: PRK05362
546271000279	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
546271000280	S-layer homology domain; Region: SLH; pfam00395
546271000281	Protein of unknown function (DUF1659); Region: DUF1659; pfam07872
546271000282	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
546271000283	Response regulator receiver domain; Region: Response_reg; pfam00072
546271000284	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546271000285	active site
546271000286	phosphorylation site [posttranslational modification]
546271000287	intermolecular recognition site; other site
546271000288	dimerization interface [polypeptide binding]; other site
546271000289	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
546271000290	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
546271000291	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
546271000292	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
546271000293	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
546271000294	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
546271000295	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
546271000296	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
546271000297	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
546271000298	putative substrate-binding site; other site
546271000299	nickel binding site [ion binding]; other site
546271000300	HupF/HypC family; Region: HupF_HypC; pfam01455
546271000301	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
546271000302	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
546271000303	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
546271000304	dimerization interface [polypeptide binding]; other site
546271000305	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
546271000306	ATP binding site [chemical binding]; other site
546271000307	6-carboxyhexanoate--CoA ligase; Region: BioW; cl00625
546271000308	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
546271000309	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
546271000310	substrate-cofactor binding pocket; other site
546271000311	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546271000312	catalytic residue [active]
546271000313	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
546271000314	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
546271000315	radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038
546271000316	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546271000317	FeS/SAM binding site; other site
546271000318	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
546271000319	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
546271000320	YvrJ protein family; Region: YvrJ; pfam12841
546271000321	Nitrous oxide-stimulated promoter; Region: YgbA_NO; cl08119
546271000322	Sensor protein DegS; Region: DegS; pfam05384
546271000323	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
546271000324	Histidine kinase; Region: HisKA_3; pfam07730
546271000325	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546271000326	ATP binding site [chemical binding]; other site
546271000327	Mg2+ binding site [ion binding]; other site
546271000328	G-X-G motif; other site
546271000329	Orn/Lys/Arg decarboxylase, major domain; Region: OKR_DC_1; pfam01276
546271000330	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
546271000331	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
546271000332	catalytic residue [active]
546271000333	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
546271000334	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
546271000335	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
546271000336	NADP binding site [chemical binding]; other site
546271000337	active site
546271000338	putative substrate binding site [chemical binding]; other site
546271000339	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
546271000340	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
546271000341	NAD(P) binding site [chemical binding]; other site
546271000342	active site
546271000343	Cupin domain; Region: Cupin_2; pfam07883
546271000344	Uncharacterized conserved protein [Function unknown]; Region: COG1434
546271000345	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
546271000346	putative active site [active]
546271000347	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
546271000348	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
546271000349	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
546271000350	regulatory protein UhpC; Provisional; Region: PRK11663
546271000351	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546271000352	putative substrate translocation pore; other site
546271000353	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
546271000354	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
546271000355	dimer interface [polypeptide binding]; other site
546271000356	putative CheW interface [polypeptide binding]; other site
546271000357	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
546271000358	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
546271000359	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
546271000360	active site
546271000361	metal binding site [ion binding]; metal-binding site
546271000362	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
546271000363	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
546271000364	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
546271000365	NADH dehydrogenase subunit B; Validated; Region: PRK06411
546271000366	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329
546271000367	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
546271000368	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
546271000369	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
546271000370	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
546271000371	4Fe-4S binding domain; Region: Fer4; pfam00037
546271000372	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
546271000373	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
546271000374	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
546271000375	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376
546271000376	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
546271000377	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
546271000378	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
546271000379	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
546271000380	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
546271000381	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
546271000382	Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848
546271000383	Uncharacterized conserved protein [Function unknown]; Region: COG3410
546271000384	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
546271000385	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
546271000386	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
546271000387	WYL domain; Region: WYL; pfam13280
546271000388	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
546271000389	WYL domain; Region: WYL; pfam13280
546271000390	CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455
546271000391	CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455
546271000392	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439
546271000393	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680
546271000394	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
546271000395	CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558
546271000396	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
546271000397	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
546271000398	CRISPR-associated protein, TIGR03984 family; Region: TIGR03984
546271000399	CRISPR-associated protein; Region: TIGR03986
546271000400	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
546271000401	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
546271000402	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
546271000403	HIGH motif; other site
546271000404	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
546271000405	active site
546271000406	KMSKS motif; other site
546271000407	Uncharacterized conserved protein [Function unknown]; Region: COG2968
546271000408	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
546271000409	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
546271000410	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
546271000411	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
546271000412	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
546271000413	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
546271000414	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
546271000415	NodB motif; other site
546271000416	active site
546271000417	metal binding site [ion binding]; metal-binding site
546271000418	PilZ domain; Region: PilZ; pfam07238
546271000419	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
546271000420	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
546271000421	DXD motif; other site
546271000422	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
546271000423	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
546271000424	active site
546271000425	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
546271000426	NodB motif; other site
546271000427	active site
546271000428	catalytic site [active]
546271000429	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
546271000430	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
546271000431	NodB motif; other site
546271000432	active site
546271000433	catalytic site [active]
546271000434	metal binding site [ion binding]; metal-binding site
546271000435	Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180
546271000436	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546271000437	FeS/SAM binding site; other site
546271000438	hypothetical protein; Provisional; Region: PRK03881
546271000439	The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951
546271000440	AMMECR1; Region: AMMECR1; pfam01871
546271000441	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
546271000442	Aspartase; Region: Aspartase; cd01357
546271000443	active sites [active]
546271000444	tetramer interface [polypeptide binding]; other site
546271000445	Predicted transcriptional regulator [Transcription]; Region: COG2944
546271000446	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
546271000447	non-specific DNA binding site [nucleotide binding]; other site
546271000448	salt bridge; other site
546271000449	sequence-specific DNA binding site [nucleotide binding]; other site
546271000450	Radical SAM superfamily; Region: Radical_SAM; pfam04055
546271000451	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546271000452	FeS/SAM binding site; other site
546271000453	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
546271000454	Sulfatase; Region: Sulfatase; cl17466
546271000455	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
546271000456	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
546271000457	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
546271000458	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
546271000459	AAA domain; Region: AAA_26; pfam13500
546271000460	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
546271000461	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
546271000462	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
546271000463	inhibitor-cofactor binding pocket; inhibition site
546271000464	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546271000465	catalytic residue [active]
546271000466	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
546271000467	active pocket/dimerization site; other site
546271000468	active site
546271000469	phosphorylation site [posttranslational modification]
546271000470	6-phosphofructokinase; Provisional; Region: PRK03202
546271000471	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
546271000472	active site
546271000473	ADP/pyrophosphate binding site [chemical binding]; other site
546271000474	dimerization interface [polypeptide binding]; other site
546271000475	allosteric effector site; other site
546271000476	fructose-1,6-bisphosphate binding site; other site
546271000477	diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921
546271000478	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
546271000479	Predicted permeases [General function prediction only]; Region: RarD; COG2962
546271000480	Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515
546271000481	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
546271000482	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
546271000483	catalytic triad [active]
546271000484	catalytic triad [active]
546271000485	oxyanion hole [active]
546271000486	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
546271000487	HicB family; Region: HicB; pfam05534
546271000488	Uncharacterized conserved protein [Function unknown]; Region: COG3339
546271000489	Double zinc ribbon; Region: DZR; pfam12773
546271000490	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
546271000491	Protein of unknown function (DUF805); Region: DUF805; pfam05656
546271000492	Transposase IS200 like; Region: Y1_Tnp; pfam01797
546271000493	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
546271000494	Catalytic domain of Protein Kinases; Region: PKc; cd00180
546271000495	active site
546271000496	ATP binding site [chemical binding]; other site
546271000497	substrate binding site [chemical binding]; other site
546271000498	activation loop (A-loop); other site
546271000499	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
546271000500	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
546271000501	dimer interface [polypeptide binding]; other site
546271000502	putative CheW interface [polypeptide binding]; other site
546271000503	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546271000504	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546271000505	active site
546271000506	I-site; other site
546271000507	metal binding site [ion binding]; metal-binding site
546271000508	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
546271000509	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
546271000510	Membrane transport protein; Region: Mem_trans; cl09117
546271000511	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
546271000512	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
546271000513	N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cl02206
546271000514	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
546271000515	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
546271000516	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
546271000517	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
546271000518	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
546271000519	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
546271000520	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
546271000521	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
546271000522	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
546271000523	catalytic residues [active]
546271000524	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
546271000525	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
546271000526	hinge; other site
546271000527	active site
546271000528	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
546271000529	GTP cyclohydrolase I; Provisional; Region: PLN03044
546271000530	active site
546271000531	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
546271000532	dihydropteroate synthase; Region: DHPS; TIGR01496
546271000533	substrate binding pocket [chemical binding]; other site
546271000534	dimer interface [polypeptide binding]; other site
546271000535	inhibitor binding site; inhibition site
546271000536	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
546271000537	homooctamer interface [polypeptide binding]; other site
546271000538	active site
546271000539	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
546271000540	catalytic center binding site [active]
546271000541	ATP binding site [chemical binding]; other site
546271000542	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546271000543	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546271000544	metal binding site [ion binding]; metal-binding site
546271000545	active site
546271000546	I-site; other site
546271000547	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
546271000548	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
546271000549	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
546271000550	dimerization interface [polypeptide binding]; other site
546271000551	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
546271000552	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
546271000553	dimer interface [polypeptide binding]; other site
546271000554	putative CheW interface [polypeptide binding]; other site
546271000555	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
546271000556	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
546271000557	Walker A motif; other site
546271000558	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
546271000559	MarR family; Region: MarR; pfam01047
546271000560	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
546271000561	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
546271000562	intersubunit interface [polypeptide binding]; other site
546271000563	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
546271000564	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
546271000565	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
546271000566	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
546271000567	ABC-ATPase subunit  interface; other site
546271000568	dimer interface [polypeptide binding]; other site
546271000569	putative PBP binding regions; other site
546271000570	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
546271000571	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
546271000572	ABC-ATPase subunit  interface; other site
546271000573	dimer interface [polypeptide binding]; other site
546271000574	putative PBP binding regions; other site
546271000575	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
546271000576	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
546271000577	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
546271000578	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
546271000579	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
546271000580	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
546271000581	Fe2+ transport protein; Region: Iron_transport; pfam10634
546271000582	Predicted membrane protein [Function unknown]; Region: COG4393
546271000583	Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080
546271000584	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
546271000585	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
546271000586	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
546271000587	FtsX-like permease family; Region: FtsX; pfam02687
546271000588	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
546271000589	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
546271000590	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
546271000591	Walker A/P-loop; other site
546271000592	ATP binding site [chemical binding]; other site
546271000593	Q-loop/lid; other site
546271000594	ABC transporter signature motif; other site
546271000595	Walker B; other site
546271000596	D-loop; other site
546271000597	H-loop/switch region; other site
546271000598	FMN-binding domain; Region: FMN_bind; cl01081
546271000599	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
546271000600	ApbE family; Region: ApbE; pfam02424
546271000601	N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cd09846
546271000602	Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; cl01973
546271000603	Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; cl01973
546271000604	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
546271000605	enolase; Provisional; Region: eno; PRK00077
546271000606	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
546271000607	dimer interface [polypeptide binding]; other site
546271000608	metal binding site [ion binding]; metal-binding site
546271000609	substrate binding pocket [chemical binding]; other site
546271000610	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
546271000611	metal-binding site [ion binding]
546271000612	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
546271000613	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
546271000614	Zn2+ binding site [ion binding]; other site
546271000615	Mg2+ binding site [ion binding]; other site
546271000616	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
546271000617	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
546271000618	Zn2+ binding site [ion binding]; other site
546271000619	Mg2+ binding site [ion binding]; other site
546271000620	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
546271000621	metal binding triad [ion binding]; metal-binding site
546271000622	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
546271000623	putative FMN binding site [chemical binding]; other site
546271000624	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
546271000625	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
546271000626	non-specific DNA binding site [nucleotide binding]; other site
546271000627	salt bridge; other site
546271000628	sequence-specific DNA binding site [nucleotide binding]; other site
546271000629	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
546271000630	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
546271000631	N-terminal plug; other site
546271000632	ligand-binding site [chemical binding]; other site
546271000633	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
546271000634	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
546271000635	intersubunit interface [polypeptide binding]; other site
546271000636	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
546271000637	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
546271000638	ABC-ATPase subunit  interface; other site
546271000639	dimer interface [polypeptide binding]; other site
546271000640	putative PBP binding regions; other site
546271000641	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
546271000642	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
546271000643	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546271000644	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
546271000645	putative substrate translocation pore; other site
546271000646	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
546271000647	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
546271000648	acyl-activating enzyme (AAE) consensus motif; other site
546271000649	AMP binding site [chemical binding]; other site
546271000650	active site
546271000651	CoA binding site [chemical binding]; other site
546271000652	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
546271000653	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
546271000654	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
546271000655	antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870
546271000656	toxin interface [polypeptide binding]; other site
546271000657	Zn binding site [ion binding]; other site
546271000658	Esterase/lipase [General function prediction only]; Region: COG1647
546271000659	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
546271000660	CoenzymeA binding site [chemical binding]; other site
546271000661	subunit interaction site [polypeptide binding]; other site
546271000662	PHB binding site; other site
546271000663	ribonuclease R; Region: RNase_R; TIGR02063
546271000664	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
546271000665	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
546271000666	RNB domain; Region: RNB; pfam00773
546271000667	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
546271000668	RNA binding site [nucleotide binding]; other site
546271000669	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
546271000670	SmpB-tmRNA interface; other site
546271000671	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
546271000672	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
546271000673	dimerization interface [polypeptide binding]; other site
546271000674	putative DNA binding site [nucleotide binding]; other site
546271000675	putative Zn2+ binding site [ion binding]; other site
546271000676	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
546271000677	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
546271000678	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
546271000679	SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913
546271000680	NlpC/P60 family; Region: NLPC_P60; cl17555
546271000681	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
546271000682	TIGR02452 family protein; Region: TIGR02452
546271000683	Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021
546271000684	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
546271000685	Domain of unknown function (DUF1413); Region: DUF1413; pfam07205
546271000686	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
546271000687	Domain of unknown function (DUF4234); Region: DUF4234; pfam14018
546271000688	Domain of unknown function (DUF4234); Region: DUF4234; pfam14018
546271000689	Domain of unknown function (DUF4234); Region: DUF4234; pfam14018
546271000690	Asp23 family; Region: Asp23; pfam03780
546271000691	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
546271000692	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
546271000693	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
546271000694	NodB motif; other site
546271000695	active site
546271000696	catalytic site [active]
546271000697	Zn binding site [ion binding]; other site
546271000698	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
546271000699	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
546271000700	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546271000701	homodimer interface [polypeptide binding]; other site
546271000702	catalytic residue [active]
546271000703	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
546271000704	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
546271000705	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
546271000706	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
546271000707	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
546271000708	FIST N domain; Region: FIST; smart00897
546271000709	FIST C domain; Region: FIST_C; pfam10442
546271000710	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
546271000711	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
546271000712	dimer interface [polypeptide binding]; other site
546271000713	putative CheW interface [polypeptide binding]; other site
546271000714	AzlC protein; Region: AzlC; cl00570
546271000715	Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687
546271000716	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
546271000717	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
546271000718	catalytic residues [active]
546271000719	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
546271000720	active site clefts [active]
546271000721	zinc binding site [ion binding]; other site
546271000722	dimer interface [polypeptide binding]; other site
546271000723	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
546271000724	putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700
546271000725	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
546271000726	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
546271000727	ArsC family; Region: ArsC; pfam03960
546271000728	putative ArsC-like catalytic residues; other site
546271000729	putative TRX-like catalytic residues [active]
546271000730	flagellar operon protein TIGR03826; Region: YvyF
546271000731	Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052
546271000732	FlgN protein; Region: FlgN; pfam05130
546271000733	FlgN protein; Region: FlgN; pfam05130
546271000734	flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492
546271000735	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
546271000736	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870
546271000737	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
546271000738	flagellar assembly protein FliW; Provisional; Region: PRK13285
546271000739	Global regulator protein family; Region: CsrA; cl00670
546271000740	FlaG protein; Region: FlaG; pfam03646
546271000741	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
546271000742	Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516
546271000743	Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344
546271000744	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
546271000745	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
546271000746	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
546271000747	active site
546271000748	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
546271000749	active site
546271000750	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
546271000751	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
546271000752	putative metal binding site; other site
546271000753	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
546271000754	binding surface
546271000755	TPR motif; other site
546271000756	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
546271000757	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
546271000758	active site
546271000759	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546271000760	binding surface
546271000761	TPR motif; other site
546271000762	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
546271000763	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
546271000764	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
546271000765	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
546271000766	invasion protein regulator; Provisional; Region: PRK12370
546271000767	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546271000768	S-adenosylmethionine binding site [chemical binding]; other site
546271000769	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
546271000770	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
546271000771	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
546271000772	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
546271000773	active site
546271000774	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
546271000775	active site
546271000776	metal-binding site
546271000777	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
546271000778	active site
546271000779	nucleotide binding site [chemical binding]; other site
546271000780	HIGH motif; other site
546271000781	KMSKS motif; other site
546271000782	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
546271000783	tetramer interface [polypeptide binding]; other site
546271000784	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
546271000785	active site
546271000786	Mg2+/Mn2+ binding site [ion binding]; other site
546271000787	Sulfatase; Region: Sulfatase; cl17466
546271000788	Sulfatase; Region: Sulfatase; cl17466
546271000789	Sulfatase; Region: Sulfatase; cl17466
546271000790	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
546271000791	Sulfatase; Region: Sulfatase; cl17466
546271000792	Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712
546271000793	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
546271000794	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
546271000795	active site
546271000796	lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407
546271000797	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
546271000798	inhibitor-cofactor binding pocket; inhibition site
546271000799	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546271000800	catalytic residue [active]
546271000801	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
546271000802	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
546271000803	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
546271000804	Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712
546271000805	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
546271000806	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
546271000807	NAD binding site [chemical binding]; other site
546271000808	homotetramer interface [polypeptide binding]; other site
546271000809	homodimer interface [polypeptide binding]; other site
546271000810	substrate binding site [chemical binding]; other site
546271000811	active site
546271000812	Flagellin N-methylase; Region: FliB; pfam03692
546271000813	ribonucleotide reductase-like protein; Provisional; Region: PRK06948
546271000814	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
546271000815	active site
546271000816	dimer interface [polypeptide binding]; other site
546271000817	effector binding site; other site
546271000818	TSCPD domain; Region: TSCPD; pfam12637
546271000819	hypothetical protein; Provisional; Region: PRK02237
546271000820	Autotransporter beta-domain; Region: Autotransporter; smart00869
546271000821	Transcriptional regulator [Transcription]; Region: LytR; COG1316
546271000822	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
546271000823	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
546271000824	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
546271000825	ABC transporter; Region: ABC_tran_2; pfam12848
546271000826	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
546271000827	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
546271000828	AAA domain; Region: AAA_30; pfam13604
546271000829	Family description; Region: UvrD_C_2; pfam13538
546271000830	comF family protein; Region: comF; TIGR00201
546271000831	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
546271000832	active site
546271000833	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
546271000834	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
546271000835	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
546271000836	active site
546271000837	dimer interface [polypeptide binding]; other site
546271000838	motif 1; other site
546271000839	motif 2; other site
546271000840	motif 3; other site
546271000841	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
546271000842	anticodon binding site; other site
546271000843	conserved hypothetical protein; Region: TIGR02328
546271000844	Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013
546271000845	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
546271000846	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
546271000847	inhibitor-cofactor binding pocket; inhibition site
546271000848	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546271000849	catalytic residue [active]
546271000850	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
546271000851	dimer interface [polypeptide binding]; other site
546271000852	active site
546271000853	Schiff base residues; other site
546271000854	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
546271000855	active site
546271000856	SAM binding site [chemical binding]; other site
546271000857	homodimer interface [polypeptide binding]; other site
546271000858	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
546271000859	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
546271000860	active site
546271000861	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
546271000862	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
546271000863	domain interfaces; other site
546271000864	active site
546271000865	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
546271000866	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
546271000867	tRNA; other site
546271000868	putative tRNA binding site [nucleotide binding]; other site
546271000869	putative NADP binding site [chemical binding]; other site
546271000870	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
546271000871	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
546271000872	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
546271000873	glutamate dehydrogenase; Provisional; Region: PRK09414
546271000874	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
546271000875	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
546271000876	NAD(P) binding site [chemical binding]; other site
546271000877	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
546271000878	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
546271000879	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
546271000880	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
546271000881	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
546271000882	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
546271000883	Protein of unknown function, DUF488; Region: DUF488; cl01246
546271000884	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
546271000885	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
546271000886	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
546271000887	catalytic residue [active]
546271000888	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
546271000889	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
546271000890	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
546271000891	FMN binding site [chemical binding]; other site
546271000892	substrate binding site [chemical binding]; other site
546271000893	putative catalytic residue [active]
546271000894	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
546271000895	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850
546271000896	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
546271000897	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
546271000898	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
546271000899	ADP binding site [chemical binding]; other site
546271000900	phosphagen binding site; other site
546271000901	substrate specificity loop; other site
546271000902	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
546271000903	Clp amino terminal domain; Region: Clp_N; pfam02861
546271000904	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546271000905	Walker A motif; other site
546271000906	ATP binding site [chemical binding]; other site
546271000907	Walker B motif; other site
546271000908	arginine finger; other site
546271000909	UvrB/uvrC motif; Region: UVR; pfam02151
546271000910	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546271000911	Walker A motif; other site
546271000912	ATP binding site [chemical binding]; other site
546271000913	Walker B motif; other site
546271000914	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
546271000915	DNA repair protein RadA; Provisional; Region: PRK11823
546271000916	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
546271000917	Walker A motif/ATP binding site; other site
546271000918	ATP binding site [chemical binding]; other site
546271000919	Walker B motif; other site
546271000920	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
546271000921	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
546271000922	amino acid carrier protein; Region: agcS; TIGR00835
546271000923	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
546271000924	tetramerization interface [polypeptide binding]; other site
546271000925	active site
546271000926	pantoate--beta-alanine ligase; Region: panC; TIGR00018
546271000927	Pantoate-beta-alanine ligase; Region: PanC; cd00560
546271000928	active site
546271000929	ATP-binding site [chemical binding]; other site
546271000930	pantoate-binding site; other site
546271000931	HXXH motif; other site
546271000932	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
546271000933	Sodium Bile acid symporter family; Region: SBF; pfam01758
546271000934	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
546271000935	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
546271000936	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
546271000937	substrate binding site [chemical binding]; other site
546271000938	ATP binding site [chemical binding]; other site
546271000939	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
546271000940	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
546271000941	active site
546271000942	nucleotide binding site [chemical binding]; other site
546271000943	HIGH motif; other site
546271000944	KMSKS motif; other site
546271000945	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
546271000946	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
546271000947	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
546271000948	putative active site [active]
546271000949	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
546271000950	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
546271000951	putative active site [active]
546271000952	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
546271000953	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
546271000954	putative ribose interaction site [chemical binding]; other site
546271000955	putative ADP binding site [chemical binding]; other site
546271000956	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
546271000957	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
546271000958	NADP binding site [chemical binding]; other site
546271000959	homopentamer interface [polypeptide binding]; other site
546271000960	substrate binding site [chemical binding]; other site
546271000961	active site
546271000962	histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656
546271000963	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546271000964	active site
546271000965	motif I; other site
546271000966	motif II; other site
546271000967	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
546271000968	putative ADP-binding pocket [chemical binding]; other site
546271000969	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
546271000970	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
546271000971	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
546271000972	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
546271000973	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
546271000974	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
546271000975	Sulfatase; Region: Sulfatase; cl17466
546271000976	Glycosyltransferase family 17; Region: Glyco_transf_17; pfam04724
546271000977	Protein of unknown function (DUF535); Region: DUF535; cl01128
546271000978	Predicted ATPase [General function prediction only]; Region: COG4637
546271000979	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546271000980	Walker A/P-loop; other site
546271000981	ATP binding site [chemical binding]; other site
546271000982	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
546271000983	Q-loop/lid; other site
546271000984	ABC transporter signature motif; other site
546271000985	Walker B; other site
546271000986	D-loop; other site
546271000987	H-loop/switch region; other site
546271000988	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
546271000989	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780
546271000990	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
546271000991	Divergent AAA domain; Region: AAA_4; pfam04326
546271000992	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
546271000993	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
546271000994	active site
546271000995	NTP binding site [chemical binding]; other site
546271000996	antibiotic binding site [chemical binding]; other site
546271000997	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl17552
546271000998	Fic family protein [Function unknown]; Region: COG3177
546271000999	Fic/DOC family; Region: Fic; pfam02661
546271001000	Flavin Reductases; Region: FlaRed; cl00801
546271001001	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
546271001002	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
546271001003	ligand binding site [chemical binding]; other site
546271001004	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
546271001005	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
546271001006	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
546271001007	transmembrane helices; other site
546271001008	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
546271001009	Domain of unknown function (DUF4321); Region: DUF4321; pfam14209
546271001010	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
546271001011	Maf-like protein; Provisional; Region: PRK14361
546271001012	active site
546271001013	dimer interface [polypeptide binding]; other site
546271001014	hypothetical protein; Reviewed; Region: PRK00024
546271001015	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
546271001016	MPN+ (JAMM) motif; other site
546271001017	Zinc-binding site [ion binding]; other site
546271001018	rod shape-determining protein MreB; Provisional; Region: PRK13927
546271001019	MreB and similar proteins; Region: MreB_like; cd10225
546271001020	nucleotide binding site [chemical binding]; other site
546271001021	Mg binding site [ion binding]; other site
546271001022	putative protofilament interaction site [polypeptide binding]; other site
546271001023	RodZ interaction site [polypeptide binding]; other site
546271001024	rod shape-determining protein MreC; Provisional; Region: PRK13922
546271001025	rod shape-determining protein MreC; Region: MreC; pfam04085
546271001026	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
546271001027	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
546271001028	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
546271001029	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
546271001030	septum formation inhibitor; Reviewed; Region: minC; PRK00513
546271001031	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
546271001032	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
546271001033	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
546271001034	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
546271001035	Switch I; other site
546271001036	Switch II; other site
546271001037	Septum formation topological specificity factor MinE; Region: MinE; cl00538
546271001038	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
546271001039	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
546271001040	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
546271001041	B12 binding site [chemical binding]; other site
546271001042	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546271001043	FeS/SAM binding site; other site
546271001044	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
546271001045	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105
546271001046	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
546271001047	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
546271001048	homodimer interface [polypeptide binding]; other site
546271001049	oligonucleotide binding site [chemical binding]; other site
546271001050	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010
546271001051	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
546271001052	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
546271001053	flagellin; Provisional; Region: PRK12806
546271001054	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
546271001055	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
546271001056	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
546271001057	PIN domain; Region: PIN_3; pfam13470
546271001058	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701
546271001059	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
546271001060	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
546271001061	Fic/DOC family; Region: Fic; cl00960
546271001062	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
546271001063	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
546271001064	NAD(P) binding site [chemical binding]; other site
546271001065	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
546271001066	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
546271001067	Homoserine O-succinyltransferase; Region: HTS; pfam04204
546271001068	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
546271001069	proposed active site lysine [active]
546271001070	conserved cys residue [active]
546271001071	biotin synthase; Provisional; Region: PRK07094
546271001072	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546271001073	FeS/SAM binding site; other site
546271001074	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
546271001075	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
546271001076	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
546271001077	PYR/PP interface [polypeptide binding]; other site
546271001078	dimer interface [polypeptide binding]; other site
546271001079	TPP binding site [chemical binding]; other site
546271001080	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
546271001081	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
546271001082	TPP-binding site [chemical binding]; other site
546271001083	dimer interface [polypeptide binding]; other site
546271001084	Sulfatase; Region: Sulfatase; cl17466
546271001085	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
546271001086	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
546271001087	putative valine binding site [chemical binding]; other site
546271001088	dimer interface [polypeptide binding]; other site
546271001089	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
546271001090	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
546271001091	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
546271001092	[FeFe] hydrogenase H-cluster radical SAM maturase HydG; Region: rSAM_HydG; TIGR03955
546271001093	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546271001094	FeS/SAM binding site; other site
546271001095	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
546271001096	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041
546271001097	RelB antitoxin; Region: RelB; cl01171
546271001098	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
546271001099	non-specific DNA binding site [nucleotide binding]; other site
546271001100	salt bridge; other site
546271001101	sequence-specific DNA binding site [nucleotide binding]; other site
546271001102	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
546271001103	thiS-thiF/thiG interaction site; other site
546271001104	thiazole synthase; Reviewed; Region: thiG; PRK00208
546271001105	phosphate binding site [ion binding]; other site
546271001106	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
546271001107	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546271001108	FeS/SAM binding site; other site
546271001109	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
546271001110	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
546271001111	thiamine phosphate binding site [chemical binding]; other site
546271001112	active site
546271001113	pyrophosphate binding site [ion binding]; other site
546271001114	fumarate hydratase; Reviewed; Region: fumC; PRK00485
546271001115	Class II fumarases; Region: Fumarase_classII; cd01362
546271001116	active site
546271001117	tetramer interface [polypeptide binding]; other site
546271001118	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546271001119	S-adenosylmethionine binding site [chemical binding]; other site
546271001120	Cache domain; Region: Cache_1; pfam02743
546271001121	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
546271001122	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
546271001123	dimerization interface [polypeptide binding]; other site
546271001124	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
546271001125	dimer interface [polypeptide binding]; other site
546271001126	putative CheW interface [polypeptide binding]; other site
546271001127	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
546271001128	nudix motif; other site
546271001129	Cache domain; Region: Cache_1; pfam02743
546271001130	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
546271001131	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
546271001132	dimerization interface [polypeptide binding]; other site
546271001133	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
546271001134	dimer interface [polypeptide binding]; other site
546271001135	putative CheW interface [polypeptide binding]; other site
546271001136	Cache domain; Region: Cache_1; pfam02743
546271001137	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
546271001138	dimerization interface [polypeptide binding]; other site
546271001139	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
546271001140	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
546271001141	dimer interface [polypeptide binding]; other site
546271001142	putative CheW interface [polypeptide binding]; other site
546271001143	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
546271001144	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
546271001145	nucleotide binding site [chemical binding]; other site
546271001146	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
546271001147	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
546271001148	active site
546271001149	dimer interface [polypeptide binding]; other site
546271001150	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
546271001151	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546271001152	active site
546271001153	motif I; other site
546271001154	motif II; other site
546271001155	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546271001156	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546271001157	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
546271001158	active site
546271001159	motif I; other site
546271001160	motif II; other site
546271001161	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
546271001162	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
546271001163	AAA domain; Region: AAA_33; pfam13671
546271001164	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
546271001165	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
546271001166	phosphate binding site [ion binding]; other site
546271001167	putative substrate binding pocket [chemical binding]; other site
546271001168	dimer interface [polypeptide binding]; other site
546271001169	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
546271001170	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
546271001171	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
546271001172	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
546271001173	putative active site [active]
546271001174	putative metal binding site [ion binding]; other site
546271001175	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
546271001176	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
546271001177	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
546271001178	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
546271001179	Walker A/P-loop; other site
546271001180	ATP binding site [chemical binding]; other site
546271001181	Q-loop/lid; other site
546271001182	ABC transporter signature motif; other site
546271001183	Walker B; other site
546271001184	D-loop; other site
546271001185	H-loop/switch region; other site
546271001186	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
546271001187	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
546271001188	Walker A/P-loop; other site
546271001189	ATP binding site [chemical binding]; other site
546271001190	Q-loop/lid; other site
546271001191	ABC transporter signature motif; other site
546271001192	Walker B; other site
546271001193	D-loop; other site
546271001194	H-loop/switch region; other site
546271001195	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
546271001196	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
546271001197	TM-ABC transporter signature motif; other site
546271001198	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
546271001199	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
546271001200	TM-ABC transporter signature motif; other site
546271001201	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
546271001202	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
546271001203	putative ligand binding site [chemical binding]; other site
546271001204	Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083
546271001205	molybdenum-pterin binding domain; Region: Mop; TIGR00638
546271001206	Rrf2 family protein; Region: rrf2_super; TIGR00738
546271001207	Transcriptional regulator; Region: Rrf2; pfam02082
546271001208	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
546271001209	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
546271001210	dimer interface [polypeptide binding]; other site
546271001211	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546271001212	catalytic residue [active]
546271001213	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
546271001214	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
546271001215	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
546271001216	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
546271001217	intersubunit interface [polypeptide binding]; other site
546271001218	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
546271001219	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
546271001220	ABC-ATPase subunit  interface; other site
546271001221	dimer interface [polypeptide binding]; other site
546271001222	putative PBP binding regions; other site
546271001223	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
546271001224	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
546271001225	Walker A/P-loop; other site
546271001226	ATP binding site [chemical binding]; other site
546271001227	Q-loop/lid; other site
546271001228	ABC transporter signature motif; other site
546271001229	Walker B; other site
546271001230	D-loop; other site
546271001231	H-loop/switch region; other site
546271001232	prephenate dehydratase; Provisional; Region: PRK11898
546271001233	Prephenate dehydratase; Region: PDT; pfam00800
546271001234	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
546271001235	putative L-Phe binding site [chemical binding]; other site
546271001236	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
546271001237	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
546271001238	Cache domain; Region: Cache_1; pfam02743
546271001239	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
546271001240	dimerization interface [polypeptide binding]; other site
546271001241	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
546271001242	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
546271001243	dimer interface [polypeptide binding]; other site
546271001244	putative CheW interface [polypeptide binding]; other site
546271001245	Cache domain; Region: Cache_1; pfam02743
546271001246	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
546271001247	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
546271001248	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
546271001249	dimer interface [polypeptide binding]; other site
546271001250	putative CheW interface [polypeptide binding]; other site
546271001251	Cache domain; Region: Cache_1; pfam02743
546271001252	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
546271001253	dimerization interface [polypeptide binding]; other site
546271001254	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
546271001255	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
546271001256	dimer interface [polypeptide binding]; other site
546271001257	putative CheW interface [polypeptide binding]; other site
546271001258	Cache domain; Region: Cache_1; pfam02743
546271001259	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
546271001260	dimerization interface [polypeptide binding]; other site
546271001261	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
546271001262	dimer interface [polypeptide binding]; other site
546271001263	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
546271001264	putative CheW interface [polypeptide binding]; other site
546271001265	Cache domain; Region: Cache_1; pfam02743
546271001266	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
546271001267	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
546271001268	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
546271001269	dimer interface [polypeptide binding]; other site
546271001270	putative CheW interface [polypeptide binding]; other site
546271001271	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
546271001272	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
546271001273	HIGH motif; other site
546271001274	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
546271001275	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
546271001276	active site
546271001277	KMSKS motif; other site
546271001278	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
546271001279	tRNA binding surface [nucleotide binding]; other site
546271001280	anticodon binding site; other site
546271001281	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
546271001282	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
546271001283	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
546271001284	O-Antigen ligase; Region: Wzy_C; cl04850
546271001285	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
546271001286	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
546271001287	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
546271001288	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
546271001289	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680
546271001290	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
546271001291	B12 binding site [chemical binding]; other site
546271001292	cobalt ligand [ion binding]; other site
546271001293	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
546271001294	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
546271001295	Walker A; other site
546271001296	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
546271001297	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
546271001298	dimer interface [polypeptide binding]; other site
546271001299	substrate binding site [chemical binding]; other site
546271001300	metal binding site [ion binding]; metal-binding site
546271001301	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
546271001302	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
546271001303	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
546271001304	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
546271001305	carboxyltransferase (CT) interaction site; other site
546271001306	biotinylation site [posttranslational modification]; other site
546271001307	Nuclease-related domain; Region: NERD; pfam08378
546271001308	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
546271001309	binding surface
546271001310	TPR motif; other site
546271001311	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
546271001312	Sel1-like repeats; Region: SEL1; smart00671
546271001313	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
546271001314	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
546271001315	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
546271001316	rRNA interaction site [nucleotide binding]; other site
546271001317	S8 interaction site; other site
546271001318	putative laminin-1 binding site; other site
546271001319	elongation factor Ts; Provisional; Region: tsf; PRK09377
546271001320	UBA/TS-N domain; Region: UBA; pfam00627
546271001321	Elongation factor TS; Region: EF_TS; pfam00889
546271001322	Elongation factor TS; Region: EF_TS; pfam00889
546271001323	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
546271001324	putative nucleotide binding site [chemical binding]; other site
546271001325	uridine monophosphate binding site [chemical binding]; other site
546271001326	homohexameric interface [polypeptide binding]; other site
546271001327	ribosome recycling factor; Reviewed; Region: frr; PRK00083
546271001328	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
546271001329	hinge region; other site
546271001330	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
546271001331	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
546271001332	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
546271001333	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
546271001334	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
546271001335	active site
546271001336	tetramer interface [polypeptide binding]; other site
546271001337	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
546271001338	active site
546271001339	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
546271001340	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
546271001341	Surface antigen; Region: Bac_surface_Ag; pfam01103
546271001342	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
546271001343	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
546271001344	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
546271001345	active site
546271001346	HIGH motif; other site
546271001347	KMSKS motif; other site
546271001348	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
546271001349	anticodon binding site; other site
546271001350	tRNA binding surface [nucleotide binding]; other site
546271001351	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
546271001352	dimer interface [polypeptide binding]; other site
546271001353	putative tRNA-binding site [nucleotide binding]; other site
546271001354	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
546271001355	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
546271001356	active site
546271001357	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
546271001358	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
546271001359	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
546271001360	trimer interface [polypeptide binding]; other site
546271001361	active site
546271001362	substrate binding site [chemical binding]; other site
546271001363	CoA binding site [chemical binding]; other site
546271001364	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
546271001365	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
546271001366	active site
546271001367	Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712
546271001368	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
546271001369	trimer interface [polypeptide binding]; other site
546271001370	active site
546271001371	substrate binding site [chemical binding]; other site
546271001372	CoA binding site [chemical binding]; other site
546271001373	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
546271001374	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
546271001375	active site
546271001376	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
546271001377	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
546271001378	Probable Catalytic site; other site
546271001379	metal-binding site
546271001380	Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712
546271001381	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
546271001382	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
546271001383	trimer interface [polypeptide binding]; other site
546271001384	active site
546271001385	substrate binding site [chemical binding]; other site
546271001386	CoA binding site [chemical binding]; other site
546271001387	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
546271001388	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
546271001389	active site
546271001390	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
546271001391	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
546271001392	substrate binding site; other site
546271001393	Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712
546271001394	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
546271001395	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
546271001396	trimer interface [polypeptide binding]; other site
546271001397	active site
546271001398	substrate binding site [chemical binding]; other site
546271001399	CoA binding site [chemical binding]; other site
546271001400	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
546271001401	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
546271001402	active site
546271001403	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
546271001404	4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944
546271001405	active site
546271001406	catalytic residues [active]
546271001407	metal binding site [ion binding]; metal-binding site
546271001408	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
546271001409	classical (c) SDRs; Region: SDR_c; cd05233
546271001410	NAD(P) binding site [chemical binding]; other site
546271001411	active site
546271001412	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
546271001413	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
546271001414	PYR/PP interface [polypeptide binding]; other site
546271001415	dimer interface [polypeptide binding]; other site
546271001416	TPP binding site [chemical binding]; other site
546271001417	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
546271001418	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
546271001419	TPP-binding site [chemical binding]; other site
546271001420	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
546271001421	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
546271001422	active site
546271001423	metal binding site [ion binding]; metal-binding site
546271001424	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
546271001425	active site
546271001426	NAD binding site [chemical binding]; other site
546271001427	metal binding site [ion binding]; metal-binding site
546271001428	Radical SAM superfamily; Region: Radical_SAM; pfam04055
546271001429	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546271001430	FeS/SAM binding site; other site
546271001431	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
546271001432	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
546271001433	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
546271001434	NAD(P) binding site [chemical binding]; other site
546271001435	active site
546271001436	Protein of unknown function (DUF4001); Region: DUF4001; pfam13165
546271001437	SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974
546271001438	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546271001439	FeS/SAM binding site; other site
546271001440	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
546271001441	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
546271001442	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
546271001443	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
546271001444	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
546271001445	Pyridoxal phosphate biosynthesis protein [Coenzyme metabolism]; Region: PdxA; COG1995
546271001446	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
546271001447	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
546271001448	fructuronate transporter; Provisional; Region: PRK10034; cl15264
546271001449	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
546271001450	iron binding site [ion binding]; other site
546271001451	rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046
546271001452	Rubrerythrin [Energy production and conversion]; Region: COG1592
546271001453	diiron binding motif [ion binding]; other site
546271001454	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
546271001455	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
546271001456	Glycoprotease family; Region: Peptidase_M22; pfam00814
546271001457	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
546271001458	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546271001459	Coenzyme A binding pocket [chemical binding]; other site
546271001460	UGMP family protein; Validated; Region: PRK09604
546271001461	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
546271001462	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
546271001463	Probable zinc-binding domain; Region: zf-trcl; pfam13451
546271001464	CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272
546271001465	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
546271001466	Helix-turn-helix domain; Region: HTH_38; pfam13936
546271001467	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
546271001468	Integrase core domain; Region: rve; pfam00665
546271001469	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
546271001470	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
546271001471	catalytic residue [active]
546271001472	Methyltransferase domain; Region: Methyltransf_23; pfam13489
546271001473	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546271001474	S-adenosylmethionine binding site [chemical binding]; other site
546271001475	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
546271001476	phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297
546271001477	PYR/PP interface [polypeptide binding]; other site
546271001478	dimer interface [polypeptide binding]; other site
546271001479	TPP binding site [chemical binding]; other site
546271001480	Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as...; Region: TPP_PpyrDC; cd03371
546271001481	TPP-binding site; other site
546271001482	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
546271001483	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
546271001484	Soluble P-type ATPase [General function prediction only]; Region: COG4087
546271001485	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087
546271001486	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
546271001487	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
546271001488	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
546271001489	G1 box; other site
546271001490	GTP/Mg2+ binding site [chemical binding]; other site
546271001491	Switch I region; other site
546271001492	G2 box; other site
546271001493	G3 box; other site
546271001494	Switch II region; other site
546271001495	G4 box; other site
546271001496	G5 box; other site
546271001497	50S ribosomal protein L29; Reviewed; Region: PRK00306
546271001498	Nucleoside recognition; Region: Gate; pfam07670
546271001499	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
546271001500	Nucleoside recognition; Region: Gate; pfam07670
546271001501	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
546271001502	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
546271001503	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
546271001504	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546271001505	Walker A motif; other site
546271001506	ATP binding site [chemical binding]; other site
546271001507	Walker B motif; other site
546271001508	arginine finger; other site
546271001509	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
546271001510	active site
546271001511	catalytic triad [active]
546271001512	cell division protein FtsA; Region: ftsA; TIGR01174
546271001513	Cell division protein FtsA; Region: FtsA; smart00842
546271001514	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
546271001515	nucleotide binding site [chemical binding]; other site
546271001516	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
546271001517	DAK2 domain; Region: Dak2; pfam02734
546271001518	Protein of unknown function (DUF441); Region: DUF441; pfam04284
546271001519	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
546271001520	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
546271001521	substrate binding pocket [chemical binding]; other site
546271001522	membrane-bound complex binding site; other site
546271001523	hinge residues; other site
546271001524	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
546271001525	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546271001526	dimer interface [polypeptide binding]; other site
546271001527	conserved gate region; other site
546271001528	putative PBP binding loops; other site
546271001529	ABC-ATPase subunit interface; other site
546271001530	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
546271001531	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
546271001532	Walker A/P-loop; other site
546271001533	ATP binding site [chemical binding]; other site
546271001534	Q-loop/lid; other site
546271001535	ABC transporter signature motif; other site
546271001536	Walker B; other site
546271001537	D-loop; other site
546271001538	H-loop/switch region; other site
546271001539	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
546271001540	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
546271001541	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
546271001542	Catalytic site [active]
546271001543	Predicted acetyltransferase [General function prediction only]; Region: COG2388
546271001544	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519
546271001545	active site flap/lid [active]
546271001546	nucleophilic elbow; other site
546271001547	catalytic triad [active]
546271001548	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
546271001549	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546271001550	S-adenosylmethionine binding site [chemical binding]; other site
546271001551	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
546271001552	RNA methyltransferase, RsmE family; Region: TIGR00046
546271001553	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
546271001554	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
546271001555	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546271001556	FeS/SAM binding site; other site
546271001557	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
546271001558	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546271001559	active site
546271001560	phosphorylation site [posttranslational modification]
546271001561	intermolecular recognition site; other site
546271001562	dimerization interface [polypeptide binding]; other site
546271001563	LytTr DNA-binding domain; Region: LytTR; smart00850
546271001564	Ion transport protein; Region: Ion_trans; pfam00520
546271001565	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
546271001566	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
546271001567	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
546271001568	Surface antigen; Region: Bac_surface_Ag; pfam01103
546271001569	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
546271001570	RelB antitoxin; Region: RelB; cl01171
546271001571	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
546271001572	nucleotide binding site/active site [active]
546271001573	HIT family signature motif; other site
546271001574	catalytic residue [active]
546271001575	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
546271001576	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
546271001577	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
546271001578	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
546271001579	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
546271001580	non-specific DNA binding site [nucleotide binding]; other site
546271001581	salt bridge; other site
546271001582	sequence-specific DNA binding site [nucleotide binding]; other site
546271001583	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
546271001584	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
546271001585	putative [4Fe-4S] binding site [ion binding]; other site
546271001586	putative molybdopterin cofactor binding site [chemical binding]; other site
546271001587	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
546271001588	molybdopterin cofactor binding site; other site
546271001589	ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283
546271001590	Walker A/P-loop; other site
546271001591	ATP binding site [chemical binding]; other site
546271001592	Q-loop/lid; other site
546271001593	ABC transporter signature motif; other site
546271001594	Walker B; other site
546271001595	D-loop; other site
546271001596	H-loop/switch region; other site
546271001597	RelB antitoxin; Region: RelB; cl01171
546271001598	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
546271001599	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546271001600	Walker A/P-loop; other site
546271001601	ATP binding site [chemical binding]; other site
546271001602	ABC transporter; Region: ABC_tran; pfam00005
546271001603	Q-loop/lid; other site
546271001604	ABC transporter signature motif; other site
546271001605	Walker B; other site
546271001606	D-loop; other site
546271001607	CcmB protein; Region: CcmB; cl17444
546271001608	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
546271001609	CcmE; Region: CcmE; cl00994
546271001610	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
546271001611	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
546271001612	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
546271001613	Cytochrome c552; Region: Cytochrom_C552; pfam02335
546271001614	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
546271001615	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
546271001616	HAMP domain; Region: HAMP; pfam00672
546271001617	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
546271001618	dimer interface [polypeptide binding]; other site
546271001619	putative CheW interface [polypeptide binding]; other site
546271001620	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
546271001621	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
546271001622	homodimer interface [polypeptide binding]; other site
546271001623	substrate-cofactor binding pocket; other site
546271001624	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546271001625	catalytic residue [active]
546271001626	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
546271001627	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
546271001628	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
546271001629	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
546271001630	Fic family protein [Function unknown]; Region: COG3177
546271001631	Fic/DOC family; Region: Fic; pfam02661
546271001632	Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693
546271001633	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
546271001634	RNA/DNA hybrid binding site [nucleotide binding]; other site
546271001635	active site
546271001636	Protein of unknown function (DUF805); Region: DUF805; cl01224
546271001637	exopolyphosphatase; Region: exo_poly_only; TIGR03706
546271001638	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
546271001639	hypothetical protein; Provisional; Region: PRK10621
546271001640	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
546271001641	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
546271001642	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
546271001643	GIY-YIG motif/motif A; other site
546271001644	active site
546271001645	catalytic site [active]
546271001646	putative DNA binding site [nucleotide binding]; other site
546271001647	metal binding site [ion binding]; metal-binding site
546271001648	UvrB/uvrC motif; Region: UVR; pfam02151
546271001649	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
546271001650	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
546271001651	recombinase A; Provisional; Region: recA; PRK09354
546271001652	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
546271001653	hexamer interface [polypeptide binding]; other site
546271001654	Walker A motif; other site
546271001655	ATP binding site [chemical binding]; other site
546271001656	Walker B motif; other site
546271001657	recombination regulator RecX; Reviewed; Region: recX; PRK00117
546271001658	GMP synthase; Reviewed; Region: guaA; PRK00074
546271001659	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
546271001660	AMP/PPi binding site [chemical binding]; other site
546271001661	candidate oxyanion hole; other site
546271001662	catalytic triad [active]
546271001663	potential glutamine specificity residues [chemical binding]; other site
546271001664	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
546271001665	ATP Binding subdomain [chemical binding]; other site
546271001666	Ligand Binding sites [chemical binding]; other site
546271001667	Dimerization subdomain; other site
546271001668	Helix-turn-helix domain; Region: HTH_17; pfam12728
546271001669	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
546271001670	DpnII restriction endonuclease; Region: DpnII; pfam04556
546271001671	DNA methylase; Region: N6_N4_Mtase; cl17433
546271001672	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546271001673	S-adenosylmethionine binding site [chemical binding]; other site
546271001674	DNA methylase; Region: N6_N4_Mtase; cl17433
546271001675	AAA domain; Region: AAA_21; pfam13304
546271001676	Protein of unknown function (DUF1679); Region: DUF1679; pfam07914
546271001677	Helix-turn-helix domain; Region: HTH_38; pfam13936
546271001678	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
546271001679	Homeodomain-like domain; Region: HTH_32; pfam13565
546271001680	Integrase core domain; Region: rve; pfam00665
546271001681	Integrase core domain; Region: rve_3; cl15866
546271001682	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
546271001683	Transposase, Mutator family; Region: Transposase_mut; pfam00872
546271001684	MULE transposase domain; Region: MULE; pfam10551
546271001685	Helix-turn-helix domain; Region: HTH_38; pfam13936
546271001686	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
546271001687	Integrase core domain; Region: rve; pfam00665
546271001688	putative transposase OrfB; Reviewed; Region: PHA02517
546271001689	HTH-like domain; Region: HTH_21; pfam13276
546271001690	Integrase core domain; Region: rve; pfam00665
546271001691	Integrase core domain; Region: rve_3; pfam13683
546271001692	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
546271001693	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
546271001694	DNA binding site [nucleotide binding]
546271001695	active site
546271001696	Domain of unknown function (DUF2828); Region: DUF2828; pfam11443
546271001697	Transposase IS200 like; Region: Y1_Tnp; pfam01797
546271001698	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
546271001699	Walker A motif; other site
546271001700	ATP binding site [chemical binding]; other site
546271001701	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
546271001702	Walker B motif; other site
546271001703	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
546271001704	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
546271001705	Walker A motif; other site
546271001706	ATP binding site [chemical binding]; other site
546271001707	Walker B motif; other site
546271001708	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
546271001709	conjugal transfer ATPase TrbE; Provisional; Region: PRK13873
546271001710	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
546271001711	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
546271001712	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
546271001713	conjugal transfer protein TrbJ; Provisional; Region: PRK13874; cl02193
546271001714	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
546271001715	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
546271001716	Peptidase family M23; Region: Peptidase_M23; pfam01551
546271001717	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
546271001718	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
546271001719	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
546271001720	N-acetyl-D-glucosamine binding site [chemical binding]; other site
546271001721	catalytic residue [active]
546271001722	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
546271001723	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
546271001724	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
546271001725	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
546271001726	non-specific DNA binding site [nucleotide binding]; other site
546271001727	salt bridge; other site
546271001728	sequence-specific DNA binding site [nucleotide binding]; other site
546271001729	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
546271001730	non-specific DNA binding site [nucleotide binding]; other site
546271001731	salt bridge; other site
546271001732	sequence-specific DNA binding site [nucleotide binding]; other site
546271001733	DNA topoisomerase III; Provisional; Region: PRK07726
546271001734	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
546271001735	active site
546271001736	putative interdomain interaction site [polypeptide binding]; other site
546271001737	putative metal-binding site [ion binding]; other site
546271001738	putative nucleotide binding site [chemical binding]; other site
546271001739	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
546271001740	domain I; other site
546271001741	DNA binding groove [nucleotide binding]
546271001742	phosphate binding site [ion binding]; other site
546271001743	domain II; other site
546271001744	domain III; other site
546271001745	nucleotide binding site [chemical binding]; other site
546271001746	catalytic site [active]
546271001747	domain IV; other site
546271001748	VbhA antitoxin and related proteins; Region: VbhA_like; cd11586
546271001749	FIC domain binding interface [polypeptide binding]; other site
546271001750	Fic/DOC family; Region: Fic; cl00960
546271001751	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
546271001752	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
546271001753	catalytic residues [active]
546271001754	catalytic nucleophile [active]
546271001755	Presynaptic Site I dimer interface [polypeptide binding]; other site
546271001756	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
546271001757	Synaptic Flat tetramer interface [polypeptide binding]; other site
546271001758	Synaptic Site I dimer interface [polypeptide binding]; other site
546271001759	DNA binding site [nucleotide binding]
546271001760	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
546271001761	DNA-binding interface [nucleotide binding]; DNA binding site
546271001762	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
546271001763	VbhA antitoxin and related proteins; Region: VbhA_like; cd11586
546271001764	FIC domain binding interface [polypeptide binding]; other site
546271001765	Domain of unknown function (DUF1413); Region: DUF1413; pfam07205
546271001766	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
546271001767	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
546271001768	DNA binding site [nucleotide binding]
546271001769	active site
546271001770	hybrid cluster protein; Provisional; Region: PRK05290
546271001771	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
546271001772	ACS interaction site; other site
546271001773	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
546271001774	hybrid metal cluster; other site
546271001775	Hemerythrin; Region: Hemerythrin; cd12107
546271001776	Fe binding site [ion binding]; other site
546271001777	Hemerythrin; Region: Hemerythrin; cd12107
546271001778	Fe binding site [ion binding]; other site
546271001779	recombination factor protein RarA; Reviewed; Region: PRK13342
546271001780	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546271001781	Walker A motif; other site
546271001782	ATP binding site [chemical binding]; other site
546271001783	Walker B motif; other site
546271001784	arginine finger; other site
546271001785	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
546271001786	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
546271001787	dimerization interface [polypeptide binding]; other site
546271001788	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
546271001789	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
546271001790	dimer interface [polypeptide binding]; other site
546271001791	putative CheW interface [polypeptide binding]; other site
546271001792	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
546271001793	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546271001794	Walker A/P-loop; other site
546271001795	ATP binding site [chemical binding]; other site
546271001796	Q-loop/lid; other site
546271001797	ABC transporter signature motif; other site
546271001798	Walker B; other site
546271001799	D-loop; other site
546271001800	H-loop/switch region; other site
546271001801	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
546271001802	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
546271001803	TM-ABC transporter signature motif; other site
546271001804	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
546271001805	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
546271001806	zinc binding site [ion binding]; other site
546271001807	putative ligand binding site [chemical binding]; other site
546271001808	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546271001809	PAS fold; Region: PAS_3; pfam08447
546271001810	putative active site [active]
546271001811	heme pocket [chemical binding]; other site
546271001812	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546271001813	PAS fold; Region: PAS_3; pfam08447
546271001814	putative active site [active]
546271001815	heme pocket [chemical binding]; other site
546271001816	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
546271001817	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
546271001818	dimer interface [polypeptide binding]; other site
546271001819	putative CheW interface [polypeptide binding]; other site
546271001820	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
546271001821	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
546271001822	substrate binding pocket [chemical binding]; other site
546271001823	membrane-bound complex binding site; other site
546271001824	hinge residues; other site
546271001825	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
546271001826	Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253
546271001827	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
546271001828	MarR family; Region: MarR; pfam01047
546271001829	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
546271001830	HlyD family secretion protein; Region: HlyD_3; pfam13437
546271001831	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
546271001832	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546271001833	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546271001834	metal binding site [ion binding]; metal-binding site
546271001835	active site
546271001836	I-site; other site
546271001837	Protein of unknown function (DUF997); Region: DUF997; cl01614
546271001838	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
546271001839	Na binding site [ion binding]; other site
546271001840	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
546271001841	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
546271001842	active site
546271001843	metal binding site [ion binding]; metal-binding site
546271001844	DNA binding site [nucleotide binding]
546271001845	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
546271001846	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
546271001847	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546271001848	Walker A/P-loop; other site
546271001849	ATP binding site [chemical binding]; other site
546271001850	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
546271001851	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
546271001852	Q-loop/lid; other site
546271001853	ABC transporter signature motif; other site
546271001854	Walker B; other site
546271001855	D-loop; other site
546271001856	H-loop/switch region; other site
546271001857	Uncharacterized conserved protein [Function unknown]; Region: COG1479
546271001858	Protein of unknown function DUF262; Region: DUF262; pfam03235
546271001859	Uncharacterized conserved protein [Function unknown]; Region: COG3472
546271001860	type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497
546271001861	HsdM N-terminal domain; Region: HsdM_N; pfam12161
546271001862	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546271001863	S-adenosylmethionine binding site [chemical binding]; other site
546271001864	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
546271001865	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
546271001866	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
546271001867	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
546271001868	non-specific DNA binding site [nucleotide binding]; other site
546271001869	salt bridge; other site
546271001870	sequence-specific DNA binding site [nucleotide binding]; other site
546271001871	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
546271001872	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
546271001873	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
546271001874	ATP binding site [chemical binding]; other site
546271001875	putative Mg++ binding site [ion binding]; other site
546271001876	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
546271001877	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
546271001878	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
546271001879	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
546271001880	dimerization interface [polypeptide binding]; other site
546271001881	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
546271001882	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
546271001883	dimer interface [polypeptide binding]; other site
546271001884	putative CheW interface [polypeptide binding]; other site
546271001885	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
546271001886	Ferritin-like domain; Region: Ferritin; pfam00210
546271001887	dimerization interface [polypeptide binding]; other site
546271001888	DPS ferroxidase diiron center [ion binding]; other site
546271001889	ion pore; other site
546271001890	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
546271001891	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
546271001892	active site
546271001893	putative catalytic site [active]
546271001894	DNA binding site [nucleotide binding]
546271001895	putative phosphate binding site [ion binding]; other site
546271001896	metal binding site A [ion binding]; metal-binding site
546271001897	AP binding site [nucleotide binding]; other site
546271001898	metal binding site B [ion binding]; metal-binding site
546271001899	Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651
546271001900	Protein of unknown function DUF262; Region: DUF262; pfam03235
546271001901	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
546271001902	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
546271001903	active site
546271001904	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
546271001905	AAA domain; Region: AAA_14; pfam13173
546271001906	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
546271001907	oligomerisation interface [polypeptide binding]; other site
546271001908	mobile loop; other site
546271001909	roof hairpin; other site
546271001910	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
546271001911	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
546271001912	ring oligomerisation interface [polypeptide binding]; other site
546271001913	ATP/Mg binding site [chemical binding]; other site
546271001914	stacking interactions; other site
546271001915	hinge regions; other site
546271001916	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
546271001917	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546271001918	dimer interface [polypeptide binding]; other site
546271001919	conserved gate region; other site
546271001920	putative PBP binding loops; other site
546271001921	ABC-ATPase subunit interface; other site
546271001922	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546271001923	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
546271001924	Walker A/P-loop; other site
546271001925	ATP binding site [chemical binding]; other site
546271001926	Q-loop/lid; other site
546271001927	ABC transporter signature motif; other site
546271001928	Walker B; other site
546271001929	D-loop; other site
546271001930	H-loop/switch region; other site
546271001931	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
546271001932	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
546271001933	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
546271001934	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
546271001935	[4Fe-4S] binding site [ion binding]; other site
546271001936	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
546271001937	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
546271001938	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
546271001939	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
546271001940	molybdopterin cofactor binding site; other site
546271001941	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
546271001942	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
546271001943	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
546271001944	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
546271001945	putative MPT binding site; other site
546271001946	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
546271001947	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
546271001948	dimer interface [polypeptide binding]; other site
546271001949	putative functional site; other site
546271001950	putative MPT binding site; other site
546271001951	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
546271001952	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546271001953	FeS/SAM binding site; other site
546271001954	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
546271001955	MOSC domain; Region: MOSC; pfam03473
546271001956	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
546271001957	MPT binding site; other site
546271001958	trimer interface [polypeptide binding]; other site
546271001959	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
546271001960	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
546271001961	GTP binding site; other site
546271001962	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
546271001963	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546271001964	S-adenosylmethionine binding site [chemical binding]; other site
546271001965	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
546271001966	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546271001967	putative substrate translocation pore; other site
546271001968	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
546271001969	trimer interface [polypeptide binding]; other site
546271001970	dimer interface [polypeptide binding]; other site
546271001971	putative active site [active]
546271001972	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
546271001973	Bax inhibitor 1 like; Region: BaxI_1; cl17691
546271001974	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
546271001975	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
546271001976	glutaminase active site [active]
546271001977	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
546271001978	dimer interface [polypeptide binding]; other site
546271001979	active site
546271001980	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
546271001981	dimer interface [polypeptide binding]; other site
546271001982	active site
546271001983	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107
546271001984	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
546271001985	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602
546271001986	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
546271001987	active site
546271001988	Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849
546271001989	Domain of unknown function (DUF1788); Region: DUF1788; pfam08747
546271001990	type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987
546271001991	Divergent AAA domain; Region: AAA_4; pfam04326
546271001992	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
546271001993	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
546271001994	TIGR02687 family protein; Region: TIGR02687
546271001995	PglZ domain; Region: PglZ; pfam08665
546271001996	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
546271001997	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
546271001998	Protein of unknown function (DUF464); Region: DUF464; pfam04327
546271001999	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
546271002000	GTPase CgtA; Reviewed; Region: obgE; PRK12297
546271002001	GTP1/OBG; Region: GTP1_OBG; pfam01018
546271002002	Obg GTPase; Region: Obg; cd01898
546271002003	G1 box; other site
546271002004	GTP/Mg2+ binding site [chemical binding]; other site
546271002005	Switch I region; other site
546271002006	G2 box; other site
546271002007	G3 box; other site
546271002008	Switch II region; other site
546271002009	G4 box; other site
546271002010	G5 box; other site
546271002011	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
546271002012	gamma-glutamyl kinase; Provisional; Region: PRK05429
546271002013	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
546271002014	nucleotide binding site [chemical binding]; other site
546271002015	homotetrameric interface [polypeptide binding]; other site
546271002016	putative phosphate binding site [ion binding]; other site
546271002017	putative allosteric binding site; other site
546271002018	PUA domain; Region: PUA; pfam01472
546271002019	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
546271002020	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
546271002021	putative catalytic cysteine [active]
546271002022	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
546271002023	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
546271002024	active site
546271002025	(T/H)XGH motif; other site
546271002026	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
546271002027	Zn2+ binding site [ion binding]; other site
546271002028	Mg2+ binding site [ion binding]; other site
546271002029	Transcriptional regulator [Transcription]; Region: LytR; COG1316
546271002030	Oligomerisation domain; Region: Oligomerisation; pfam02410
546271002031	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
546271002032	S1 domain; Region: S1_2; pfam13509
546271002033	S1 domain; Region: S1_2; pfam13509
546271002034	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
546271002035	RNA binding site [nucleotide binding]; other site
546271002036	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
546271002037	Response regulator receiver domain; Region: Response_reg; pfam00072
546271002038	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546271002039	active site
546271002040	phosphorylation site [posttranslational modification]
546271002041	intermolecular recognition site; other site
546271002042	dimerization interface [polypeptide binding]; other site
546271002043	Helix-turn-helix domain; Region: HTH_38; pfam13936
546271002044	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
546271002045	Integrase core domain; Region: rve; pfam00665
546271002046	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
546271002047	23S rRNA interface [nucleotide binding]; other site
546271002048	L3 interface [polypeptide binding]; other site
546271002049	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
546271002050	Domain of unknown function (DUF4153); Region: DUF4153; pfam13687
546271002051	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
546271002052	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
546271002053	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
546271002054	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
546271002055	active site
546271002056	metal binding site [ion binding]; metal-binding site
546271002057	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
546271002058	Stage II sporulation protein; Region: SpoIID; pfam08486
546271002059	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
546271002060	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
546271002061	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
546271002062	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
546271002063	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
546271002064	Preprotein translocase subunit; Region: YajC; pfam02699
546271002065	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
546271002066	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
546271002067	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
546271002068	protein-export membrane protein SecD; Region: secD; TIGR01129
546271002069	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
546271002070	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
546271002071	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
546271002072	Protein export membrane protein; Region: SecD_SecF; pfam02355
546271002073	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
546271002074	DHH family; Region: DHH; pfam01368
546271002075	DHHA1 domain; Region: DHHA1; pfam02272
546271002076	Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538
546271002077	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
546271002078	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
546271002079	Zn2+ binding site [ion binding]; other site
546271002080	Mg2+ binding site [ion binding]; other site
546271002081	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
546271002082	synthetase active site [active]
546271002083	NTP binding site [chemical binding]; other site
546271002084	metal binding site [ion binding]; metal-binding site
546271002085	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
546271002086	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
546271002087	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
546271002088	ferric uptake regulator; Provisional; Region: fur; PRK09462
546271002089	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
546271002090	metal binding site 2 [ion binding]; metal-binding site
546271002091	putative DNA binding helix; other site
546271002092	metal binding site 1 [ion binding]; metal-binding site
546271002093	dimer interface [polypeptide binding]; other site
546271002094	structural Zn2+ binding site [ion binding]; other site
546271002095	coproporphyrinogen dehydrogenase HemZ; Region: rSAM_HemZ; TIGR03994
546271002096	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546271002097	FeS/SAM binding site; other site
546271002098	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
546271002099	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
546271002100	dimer interface [polypeptide binding]; other site
546271002101	motif 1; other site
546271002102	active site
546271002103	motif 2; other site
546271002104	motif 3; other site
546271002105	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
546271002106	anticodon binding site; other site
546271002107	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
546271002108	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
546271002109	dimer interface [polypeptide binding]; other site
546271002110	anticodon binding site; other site
546271002111	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
546271002112	homodimer interface [polypeptide binding]; other site
546271002113	motif 1; other site
546271002114	active site
546271002115	motif 2; other site
546271002116	GAD domain; Region: GAD; pfam02938
546271002117	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
546271002118	motif 3; other site
546271002119	Cache domain; Region: Cache_1; pfam02743
546271002120	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
546271002121	dimerization interface [polypeptide binding]; other site
546271002122	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
546271002123	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
546271002124	dimer interface [polypeptide binding]; other site
546271002125	putative CheW interface [polypeptide binding]; other site
546271002126	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
546271002127	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
546271002128	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
546271002129	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
546271002130	putative homodimer interface [polypeptide binding]; other site
546271002131	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
546271002132	heterodimer interface [polypeptide binding]; other site
546271002133	homodimer interface [polypeptide binding]; other site
546271002134	Ribosomal protein L11/L12; Region: RL11; smart00649
546271002135	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
546271002136	putative thiostrepton binding site; other site
546271002137	23S rRNA interface [nucleotide binding]; other site
546271002138	L7/L12 interface [polypeptide binding]; other site
546271002139	L25 interface [polypeptide binding]; other site
546271002140	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
546271002141	mRNA/rRNA interface [nucleotide binding]; other site
546271002142	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
546271002143	23S rRNA interface [nucleotide binding]; other site
546271002144	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
546271002145	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
546271002146	core dimer interface [polypeptide binding]; other site
546271002147	peripheral dimer interface [polypeptide binding]; other site
546271002148	L10 interface [polypeptide binding]; other site
546271002149	L11 interface [polypeptide binding]; other site
546271002150	putative EF-Tu interaction site [polypeptide binding]; other site
546271002151	putative EF-G interaction site [polypeptide binding]; other site
546271002152	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546271002153	D-galactonate transporter; Region: 2A0114; TIGR00893
546271002154	putative substrate translocation pore; other site
546271002155	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546271002156	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
546271002157	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
546271002158	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
546271002159	putative active site [active]
546271002160	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
546271002161	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
546271002162	substrate binding site; other site
546271002163	dimer interface; other site
546271002164	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
546271002165	homotrimer interaction site [polypeptide binding]; other site
546271002166	zinc binding site [ion binding]; other site
546271002167	CDP-binding sites; other site
546271002168	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
546271002169	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
546271002170	active site
546271002171	HIGH motif; other site
546271002172	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
546271002173	KMSKS motif; other site
546271002174	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
546271002175	tRNA binding surface [nucleotide binding]; other site
546271002176	anticodon binding site; other site
546271002177	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
546271002178	active site
546271002179	metal binding site [ion binding]; metal-binding site
546271002180	dimerization interface [polypeptide binding]; other site
546271002181	Thymidylate synthase complementing protein; Region: Thy1; cl03630
546271002182	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
546271002183	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
546271002184	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
546271002185	YacP-like NYN domain; Region: NYN_YacP; pfam05991
546271002186	RNA polymerase factor sigma-70; Validated; Region: PRK08295
546271002187	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
546271002188	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
546271002189	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546271002190	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
546271002191	active site
546271002192	motif I; other site
546271002193	motif II; other site
546271002194	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546271002195	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
546271002196	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
546271002197	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
546271002198	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
546271002199	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
546271002200	active site
546271002201	metal binding site [ion binding]; metal-binding site
546271002202	Sporulation and spore germination; Region: Germane; pfam10646
546271002203	RelB antitoxin; Region: RelB; cl01171
546271002204	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
546271002205	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
546271002206	Na binding site [ion binding]; other site
546271002207	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
546271002208	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
546271002209	non-specific DNA binding site [nucleotide binding]; other site
546271002210	salt bridge; other site
546271002211	sequence-specific DNA binding site [nucleotide binding]; other site
546271002212	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
546271002213	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
546271002214	Response regulator receiver domain; Region: Response_reg; pfam00072
546271002215	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546271002216	active site
546271002217	phosphorylation site [posttranslational modification]
546271002218	intermolecular recognition site; other site
546271002219	dimerization interface [polypeptide binding]; other site
546271002220	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
546271002221	Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406
546271002222	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
546271002223	methionine aminopeptidase; Provisional; Region: PRK12318
546271002224	SEC-C motif; Region: SEC-C; pfam02810
546271002225	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
546271002226	active site
546271002227	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
546271002228	DEAD-like helicases superfamily; Region: DEXDc; smart00487
546271002229	ATP binding site [chemical binding]; other site
546271002230	Mg++ binding site [ion binding]; other site
546271002231	motif III; other site
546271002232	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
546271002233	nucleotide binding region [chemical binding]; other site
546271002234	ATP-binding site [chemical binding]; other site
546271002235	Cache domain; Region: Cache_1; pfam02743
546271002236	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
546271002237	dimerization interface [polypeptide binding]; other site
546271002238	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
546271002239	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
546271002240	dimer interface [polypeptide binding]; other site
546271002241	putative CheW interface [polypeptide binding]; other site
546271002242	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
546271002243	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
546271002244	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
546271002245	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
546271002246	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
546271002247	ABC transporter; Region: ABC_tran_2; pfam12848
546271002248	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
546271002249	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
546271002250	ABC1 family; Region: ABC1; cl17513
546271002251	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
546271002252	homotrimer interaction site [polypeptide binding]; other site
546271002253	active site
546271002254	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
546271002255	homotrimer interaction site [polypeptide binding]; other site
546271002256	putative active site [active]
546271002257	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
546271002258	NAD synthetase; Provisional; Region: PRK13981
546271002259	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
546271002260	multimer interface [polypeptide binding]; other site
546271002261	active site
546271002262	catalytic triad [active]
546271002263	protein interface 1 [polypeptide binding]; other site
546271002264	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
546271002265	Ligand Binding Site [chemical binding]; other site
546271002266	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
546271002267	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
546271002268	non-specific DNA binding site [nucleotide binding]; other site
546271002269	salt bridge; other site
546271002270	sequence-specific DNA binding site [nucleotide binding]; other site
546271002271	YcfA-like protein; Region: YcfA; pfam07927
546271002272	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
546271002273	putative deacylase active site [active]
546271002274	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
546271002275	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
546271002276	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546271002277	catalytic residue [active]
546271002278	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
546271002279	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
546271002280	active site
546271002281	substrate-binding site [chemical binding]; other site
546271002282	metal-binding site [ion binding]
546271002283	ATP binding site [chemical binding]; other site
546271002284	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
546271002285	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
546271002286	ssDNA binding site; other site
546271002287	generic binding surface II; other site
546271002288	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
546271002289	ATP binding site [chemical binding]; other site
546271002290	putative Mg++ binding site [ion binding]; other site
546271002291	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
546271002292	nucleotide binding region [chemical binding]; other site
546271002293	ATP-binding site [chemical binding]; other site
546271002294	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
546271002295	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
546271002296	substrate binding site; other site
546271002297	tetramer interface; other site
546271002298	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
546271002299	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
546271002300	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
546271002301	NAD binding site [chemical binding]; other site
546271002302	substrate binding site [chemical binding]; other site
546271002303	homodimer interface [polypeptide binding]; other site
546271002304	active site
546271002305	Transcriptional regulator [Transcription]; Region: LysR; COG0583
546271002306	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
546271002307	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
546271002308	dimerization interface [polypeptide binding]; other site
546271002309	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546271002310	Major Facilitator Superfamily; Region: MFS_1; pfam07690
546271002311	putative substrate translocation pore; other site
546271002312	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
546271002313	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
546271002314	Transcriptional regulator; Region: Rrf2; cl17282
546271002315	Rrf2 family protein; Region: rrf2_super; TIGR00738
546271002316	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
546271002317	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
546271002318	substrate binding pocket [chemical binding]; other site
546271002319	chain length determination region; other site
546271002320	substrate-Mg2+ binding site; other site
546271002321	catalytic residues [active]
546271002322	aspartate-rich region 1; other site
546271002323	active site lid residues [active]
546271002324	aspartate-rich region 2; other site
546271002325	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
546271002326	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
546271002327	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
546271002328	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
546271002329	menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701
546271002330	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
546271002331	UbiA prenyltransferase family; Region: UbiA; pfam01040
546271002332	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
546271002333	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
546271002334	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
546271002335	homodimer interface [polypeptide binding]; other site
546271002336	NADP binding site [chemical binding]; other site
546271002337	substrate binding site [chemical binding]; other site
546271002338	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
546271002339	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
546271002340	Potassium binding sites [ion binding]; other site
546271002341	Cesium cation binding sites [ion binding]; other site
546271002342	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
546271002343	active site
546271002344	NTP binding site [chemical binding]; other site
546271002345	metal binding triad [ion binding]; metal-binding site
546271002346	antibiotic binding site [chemical binding]; other site
546271002347	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl17552
546271002348	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
546271002349	FAD binding site [chemical binding]; other site
546271002350	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
546271002351	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
546271002352	FAD binding pocket [chemical binding]; other site
546271002353	FAD binding motif [chemical binding]; other site
546271002354	phosphate binding motif [ion binding]; other site
546271002355	beta-alpha-beta structure motif; other site
546271002356	NAD binding pocket [chemical binding]; other site
546271002357	Iron coordination center [ion binding]; other site
546271002358	putative oxidoreductase; Provisional; Region: PRK12831
546271002359	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
546271002360	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
546271002361	active site
546271002362	catalytic site [active]
546271002363	substrate binding site [chemical binding]; other site
546271002364	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
546271002365	substrate binding site [chemical binding]; other site
546271002366	ATP binding site [chemical binding]; other site
546271002367	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
546271002368	16S/18S rRNA binding site [nucleotide binding]; other site
546271002369	S13e-L30e interaction site [polypeptide binding]; other site
546271002370	25S rRNA binding site [nucleotide binding]; other site
546271002371	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
546271002372	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
546271002373	RNase E interface [polypeptide binding]; other site
546271002374	trimer interface [polypeptide binding]; other site
546271002375	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
546271002376	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
546271002377	RNase E interface [polypeptide binding]; other site
546271002378	trimer interface [polypeptide binding]; other site
546271002379	active site
546271002380	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
546271002381	putative nucleic acid binding region [nucleotide binding]; other site
546271002382	G-X-X-G motif; other site
546271002383	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
546271002384	RNA binding site [nucleotide binding]; other site
546271002385	domain interface; other site
546271002386	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
546271002387	Helix-turn-helix domain; Region: HTH_25; pfam13413
546271002388	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
546271002389	uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904
546271002390	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
546271002391	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
546271002392	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
546271002393	ATP cone domain; Region: ATP-cone; pfam03477
546271002394	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
546271002395	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
546271002396	B12 binding site [chemical binding]; other site
546271002397	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546271002398	FeS/SAM binding site; other site
546271002399	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
546271002400	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
546271002401	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
546271002402	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
546271002403	catalytic residue [active]
546271002404	Protein of unknown function (DUF552); Region: DUF552; pfam04472
546271002405	pyrroline-5-carboxylate reductase; Region: PLN02688
546271002406	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
546271002407	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
546271002408	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
546271002409	RNA binding surface [nucleotide binding]; other site
546271002410	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
546271002411	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
546271002412	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
546271002413	RNA binding surface [nucleotide binding]; other site
546271002414	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
546271002415	active site
546271002416	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
546271002417	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
546271002418	active site
546271002419	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
546271002420	Autotransporter beta-domain; Region: Autotransporter; pfam03797
546271002421	general stress protein 13; Validated; Region: PRK08059
546271002422	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
546271002423	RNA binding site [nucleotide binding]; other site
546271002424	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
546271002425	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
546271002426	Ligand Binding Site [chemical binding]; other site
546271002427	TilS substrate C-terminal domain; Region: TilS_C; smart00977
546271002428	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
546271002429	active site
546271002430	cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633
546271002431	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
546271002432	Walker A/P-loop; other site
546271002433	ATP binding site [chemical binding]; other site
546271002434	Q-loop/lid; other site
546271002435	ABC transporter signature motif; other site
546271002436	Walker B; other site
546271002437	D-loop; other site
546271002438	H-loop/switch region; other site
546271002439	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637
546271002440	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
546271002441	Walker A/P-loop; other site
546271002442	ATP binding site [chemical binding]; other site
546271002443	Q-loop/lid; other site
546271002444	ABC transporter signature motif; other site
546271002445	Walker B; other site
546271002446	D-loop; other site
546271002447	H-loop/switch region; other site
546271002448	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
546271002449	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
546271002450	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
546271002451	dimerization interface 3.5A [polypeptide binding]; other site
546271002452	active site
546271002453	Helix-turn-helix domain; Region: HTH_38; pfam13936
546271002454	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
546271002455	Integrase core domain; Region: rve; pfam00665
546271002456	RelB antitoxin; Region: RelB; cl01171
546271002457	PIN domain; Region: PIN_3; pfam13470
546271002458	excinuclease ABC subunit B; Provisional; Region: PRK05298
546271002459	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
546271002460	ATP binding site [chemical binding]; other site
546271002461	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
546271002462	nucleotide binding region [chemical binding]; other site
546271002463	ATP-binding site [chemical binding]; other site
546271002464	Ultra-violet resistance protein B; Region: UvrB; pfam12344
546271002465	UvrB/uvrC motif; Region: UVR; pfam02151
546271002466	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
546271002467	Zn2+ binding site [ion binding]; other site
546271002468	Mg2+ binding site [ion binding]; other site
546271002469	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
546271002470	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
546271002471	active site
546271002472	HIGH motif; other site
546271002473	nucleotide binding site [chemical binding]; other site
546271002474	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
546271002475	KMSKS motif; other site
546271002476	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
546271002477	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
546271002478	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
546271002479	transmembrane helices; other site
546271002480	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
546271002481	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
546271002482	HIGH motif; other site
546271002483	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
546271002484	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
546271002485	active site
546271002486	KMSKS motif; other site
546271002487	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
546271002488	tRNA binding surface [nucleotide binding]; other site
546271002489	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
546271002490	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
546271002491	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
546271002492	ATP binding site [chemical binding]; other site
546271002493	putative Mg++ binding site [ion binding]; other site
546271002494	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
546271002495	nucleotide binding region [chemical binding]; other site
546271002496	ATP-binding site [chemical binding]; other site
546271002497	TRCF domain; Region: TRCF; pfam03461
546271002498	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
546271002499	active site
546271002500	homodimer interface [polypeptide binding]; other site
546271002501	SAM binding site [chemical binding]; other site
546271002502	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
546271002503	IHF dimer interface [polypeptide binding]; other site
546271002504	IHF - DNA interface [nucleotide binding]; other site
546271002505	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
546271002506	classical (c) SDRs; Region: SDR_c; cd05233
546271002507	NAD(P) binding site [chemical binding]; other site
546271002508	active site
546271002509	UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707
546271002510	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
546271002511	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
546271002512	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
546271002513	Septum formation initiator; Region: DivIC; pfam04977
546271002514	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
546271002515	YcfA-like protein; Region: YcfA; pfam07927
546271002516	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
546271002517	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
546271002518	GTP/Mg2+ binding site [chemical binding]; other site
546271002519	G4 box; other site
546271002520	G5 box; other site
546271002521	G1 box; other site
546271002522	Switch I region; other site
546271002523	G2 box; other site
546271002524	G3 box; other site
546271002525	Switch II region; other site
546271002526	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
546271002527	RNA/DNA hybrid binding site [nucleotide binding]; other site
546271002528	active site
546271002529	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
546271002530	hypothetical protein; Reviewed; Region: PRK12497
546271002531	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
546271002532	active site
546271002533	SAM binding site [chemical binding]; other site
546271002534	homodimer interface [polypeptide binding]; other site
546271002535	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
546271002536	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
546271002537	intersubunit interface [polypeptide binding]; other site
546271002538	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
546271002539	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
546271002540	ABC-ATPase subunit  interface; other site
546271002541	dimer interface [polypeptide binding]; other site
546271002542	putative PBP binding regions; other site
546271002543	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
546271002544	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
546271002545	Walker A/P-loop; other site
546271002546	ATP binding site [chemical binding]; other site
546271002547	Q-loop/lid; other site
546271002548	ABC transporter signature motif; other site
546271002549	Walker B; other site
546271002550	D-loop; other site
546271002551	H-loop/switch region; other site
546271002552	Transcriptional regulator [Transcription]; Region: LysR; COG0583
546271002553	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
546271002554	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
546271002555	dimerization interface [polypeptide binding]; other site
546271002556	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
546271002557	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
546271002558	Walker A/P-loop; other site
546271002559	ATP binding site [chemical binding]; other site
546271002560	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
546271002561	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
546271002562	ABC transporter signature motif; other site
546271002563	Walker B; other site
546271002564	D-loop; other site
546271002565	H-loop/switch region; other site
546271002566	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
546271002567	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
546271002568	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
546271002569	P loop; other site
546271002570	GTP binding site [chemical binding]; other site
546271002571	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
546271002572	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
546271002573	G1 box; other site
546271002574	putative GEF interaction site [polypeptide binding]; other site
546271002575	GTP/Mg2+ binding site [chemical binding]; other site
546271002576	Switch I region; other site
546271002577	G2 box; other site
546271002578	G3 box; other site
546271002579	Switch II region; other site
546271002580	G4 box; other site
546271002581	G5 box; other site
546271002582	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
546271002583	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
546271002584	Protein of unknown function (DUF552); Region: DUF552; pfam04472
546271002585	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
546271002586	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
546271002587	metal binding site [ion binding]; metal-binding site
546271002588	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
546271002589	Acyltransferase family; Region: Acyl_transf_3; pfam01757
546271002590	glutamate racemase; Provisional; Region: PRK00865
546271002591	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
546271002592	active site 1 [active]
546271002593	active site 2 [active]
546271002594	AzlC protein; Region: AzlC; pfam03591
546271002595	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
546271002596	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
546271002597	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
546271002598	dimer interface [polypeptide binding]; other site
546271002599	putative CheW interface [polypeptide binding]; other site
546271002600	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
546271002601	dimer interface [polypeptide binding]; other site
546271002602	putative CheW interface [polypeptide binding]; other site
546271002603	[FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918
546271002604	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
546271002605	G1 box; other site
546271002606	GTP/Mg2+ binding site [chemical binding]; other site
546271002607	Switch I region; other site
546271002608	G2 box; other site
546271002609	Switch II region; other site
546271002610	G3 box; other site
546271002611	G4 box; other site
546271002612	G5 box; other site
546271002613	Acylphosphatase; Region: Acylphosphatase; pfam00708
546271002614	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
546271002615	HypF finger; Region: zf-HYPF; pfam07503
546271002616	HypF finger; Region: zf-HYPF; pfam07503
546271002617	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
546271002618	glutamine synthetase, type I; Region: GlnA; TIGR00653
546271002619	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
546271002620	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
546271002621	heterodimer interface [polypeptide binding]; other site
546271002622	substrate interaction site [chemical binding]; other site
546271002623	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
546271002624	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
546271002625	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
546271002626	active site
546271002627	substrate binding site [chemical binding]; other site
546271002628	coenzyme B12 binding site [chemical binding]; other site
546271002629	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
546271002630	B12 binding site [chemical binding]; other site
546271002631	cobalt ligand [ion binding]; other site
546271002632	membrane ATPase/protein kinase; Provisional; Region: PRK09435
546271002633	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
546271002634	Walker A; other site
546271002635	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
546271002636	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
546271002637	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
546271002638	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
546271002639	active site
546271002640	putative homodimer interface [polypeptide binding]; other site
546271002641	SAM binding site [chemical binding]; other site
546271002642	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
546271002643	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546271002644	S-adenosylmethionine binding site [chemical binding]; other site
546271002645	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
546271002646	Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798
546271002647	active site
546271002648	SAM binding site [chemical binding]; other site
546271002649	homodimer interface [polypeptide binding]; other site
546271002650	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
546271002651	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
546271002652	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
546271002653	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
546271002654	active site
546271002655	SAM binding site [chemical binding]; other site
546271002656	homodimer interface [polypeptide binding]; other site
546271002657	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
546271002658	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
546271002659	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
546271002660	Precorrin-8X methylmutase; Region: CbiC; pfam02570
546271002661	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
546271002662	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
546271002663	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
546271002664	catalytic triad [active]
546271002665	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
546271002666	homotrimer interface [polypeptide binding]; other site
546271002667	Walker A motif; other site
546271002668	GTP binding site [chemical binding]; other site
546271002669	Walker B motif; other site
546271002670	cobyric acid synthase; Provisional; Region: PRK00784
546271002671	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
546271002672	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
546271002673	catalytic triad [active]
546271002674	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
546271002675	cobalamin synthase; Reviewed; Region: cobS; PRK00235
546271002676	threonine-phosphate decarboxylase; Provisional; Region: PRK06358
546271002677	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
546271002678	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546271002679	homodimer interface [polypeptide binding]; other site
546271002680	catalytic residue [active]
546271002681	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
546271002682	catalytic core [active]
546271002683	hypothetical protein; Provisional; Region: PRK13670
546271002684	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
546271002685	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
546271002686	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
546271002687	Ligand Binding Site [chemical binding]; other site
546271002688	BioY family; Region: BioY; pfam02632
546271002689	LabA_like proteins; Region: LabA_like/DUF88; cl10034
546271002690	putative metal binding site [ion binding]; other site
546271002691	Domain of unknown function (DUF3783); Region: DUF3783; pfam12646
546271002692	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
546271002693	NMT1/THI5 like; Region: NMT1; pfam09084
546271002694	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
546271002695	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
546271002696	Walker A/P-loop; other site
546271002697	ATP binding site [chemical binding]; other site
546271002698	Q-loop/lid; other site
546271002699	ABC transporter signature motif; other site
546271002700	Walker B; other site
546271002701	D-loop; other site
546271002702	H-loop/switch region; other site
546271002703	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
546271002704	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546271002705	dimer interface [polypeptide binding]; other site
546271002706	conserved gate region; other site
546271002707	putative PBP binding loops; other site
546271002708	ABC-ATPase subunit interface; other site
546271002709	Late competence development protein ComFB; Region: ComFB; pfam10719
546271002710	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
546271002711	Domain of unknown function DUF21; Region: DUF21; pfam01595
546271002712	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
546271002713	Transporter associated domain; Region: CorC_HlyC; smart01091
546271002714	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
546271002715	VanW like protein; Region: VanW; pfam04294
546271002716	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
546271002717	Flavoprotein; Region: Flavoprotein; pfam02441
546271002718	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
546271002719	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
546271002720	Beta-Casp domain; Region: Beta-Casp; smart01027
546271002721	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
546271002722	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
546271002723	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
546271002724	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
546271002725	dihydroorotase; Validated; Region: pyrC; PRK09357
546271002726	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
546271002727	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
546271002728	active site
546271002729	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
546271002730	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
546271002731	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
546271002732	catalytic site [active]
546271002733	subunit interface [polypeptide binding]; other site
546271002734	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
546271002735	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
546271002736	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
546271002737	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
546271002738	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
546271002739	ATP-grasp domain; Region: ATP-grasp_4; cl17255
546271002740	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
546271002741	IMP binding site; other site
546271002742	dimer interface [polypeptide binding]; other site
546271002743	interdomain contacts; other site
546271002744	partial ornithine binding site; other site
546271002745	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
546271002746	active site
546271002747	dimer interface [polypeptide binding]; other site
546271002748	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
546271002749	active site
546271002750	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
546271002751	Aluminium resistance protein; Region: Alum_res; pfam06838
546271002752	LexA repressor; Validated; Region: PRK00215
546271002753	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
546271002754	putative DNA binding site [nucleotide binding]; other site
546271002755	putative Zn2+ binding site [ion binding]; other site
546271002756	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
546271002757	Catalytic site [active]
546271002758	Restriction endonuclease; Region: Mrr_cat; pfam04471
546271002759	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
546271002760	active site
546271002761	NTP binding site [chemical binding]; other site
546271002762	metal binding triad [ion binding]; metal-binding site
546271002763	antibiotic binding site [chemical binding]; other site
546271002764	Protein of unknown function DUF86; Region: DUF86; cl01031
546271002765	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
546271002766	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
546271002767	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
546271002768	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
546271002769	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
546271002770	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
546271002771	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
546271002772	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
546271002773	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
546271002774	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
546271002775	Transposase IS200 like; Region: Y1_Tnp; pfam01797
546271002776	WYL domain; Region: WYL; pfam13280
546271002777	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
546271002778	Protein of unknown function (DUF1643); Region: DUF1643; cl01787
546271002779	putative transposase OrfB; Reviewed; Region: PHA02517
546271002780	Integrase core domain; Region: rve; pfam00665
546271002781	Integrase core domain; Region: rve_3; pfam13683
546271002782	Transposase; Region: HTH_Tnp_1; pfam01527
546271002783	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
546271002784	putative transposase OrfB; Reviewed; Region: PHA02517
546271002785	HTH-like domain; Region: HTH_21; pfam13276
546271002786	Integrase core domain; Region: rve; pfam00665
546271002787	Integrase core domain; Region: rve_2; pfam13333
546271002788	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
546271002789	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
546271002790	Domain of unknown function (DUF4268); Region: DUF4268; pfam14088
546271002791	putative transposase OrfB; Reviewed; Region: PHA02517
546271002792	HTH-like domain; Region: HTH_21; pfam13276
546271002793	Integrase core domain; Region: rve; pfam00665
546271002794	Integrase core domain; Region: rve_3; pfam13683
546271002795	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
546271002796	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
546271002797	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
546271002798	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
546271002799	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
546271002800	TfoX N-terminal domain; Region: TfoX_N; pfam04993
546271002801	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
546271002802	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
546271002803	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
546271002804	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
546271002805	Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028
546271002806	active site
546271002807	oxaloacetate decarboxylase; Provisional; Region: PRK12331
546271002808	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
546271002809	active site
546271002810	catalytic residues [active]
546271002811	metal binding site [ion binding]; metal-binding site
546271002812	homodimer binding site [polypeptide binding]; other site
546271002813	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
546271002814	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
546271002815	homodimer interface [polypeptide binding]; other site
546271002816	substrate-cofactor binding pocket; other site
546271002817	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546271002818	catalytic residue [active]
546271002819	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
546271002820	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
546271002821	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
546271002822	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
546271002823	minor groove reading motif; other site
546271002824	helix-hairpin-helix signature motif; other site
546271002825	substrate binding pocket [chemical binding]; other site
546271002826	active site
546271002827	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
546271002828	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546271002829	Coenzyme A binding pocket [chemical binding]; other site
546271002830	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
546271002831	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
546271002832	Prephenate dehydrogenase; Region: PDH; pfam02153
546271002833	prephenate dehydrogenase; Validated; Region: PRK08507
546271002834	DNA gyrase, B subunit; Region: gyrB; TIGR01059
546271002835	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
546271002836	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
546271002837	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
546271002838	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
546271002839	RPB1 interaction site [polypeptide binding]; other site
546271002840	RPB10 interaction site [polypeptide binding]; other site
546271002841	RPB11 interaction site [polypeptide binding]; other site
546271002842	RPB3 interaction site [polypeptide binding]; other site
546271002843	RPB12 interaction site [polypeptide binding]; other site
546271002844	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
546271002845	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
546271002846	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
546271002847	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
546271002848	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
546271002849	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
546271002850	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
546271002851	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
546271002852	G-loop; other site
546271002853	DNA binding site [nucleotide binding]
546271002854	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
546271002855	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
546271002856	inhibitor-cofactor binding pocket; inhibition site
546271002857	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546271002858	catalytic residue [active]
546271002859	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
546271002860	Peptidase family U32; Region: Peptidase_U32; pfam01136
546271002861	Peptidase family U32; Region: Peptidase_U32; pfam01136
546271002862	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
546271002863	metal binding site 2 [ion binding]; metal-binding site
546271002864	putative DNA binding helix; other site
546271002865	metal binding site 1 [ion binding]; metal-binding site
546271002866	dimer interface [polypeptide binding]; other site
546271002867	structural Zn2+ binding site [ion binding]; other site
546271002868	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
546271002869	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
546271002870	FAD binding pocket [chemical binding]; other site
546271002871	FAD binding motif [chemical binding]; other site
546271002872	phosphate binding motif [ion binding]; other site
546271002873	beta-alpha-beta structure motif; other site
546271002874	NAD binding pocket [chemical binding]; other site
546271002875	Iron coordination center [ion binding]; other site
546271002876	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
546271002877	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
546271002878	heterodimer interface [polypeptide binding]; other site
546271002879	active site
546271002880	FMN binding site [chemical binding]; other site
546271002881	homodimer interface [polypeptide binding]; other site
546271002882	substrate binding site [chemical binding]; other site
546271002883	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
546271002884	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
546271002885	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
546271002886	non-specific DNA binding site [nucleotide binding]; other site
546271002887	salt bridge; other site
546271002888	sequence-specific DNA binding site [nucleotide binding]; other site
546271002889	SLBB domain; Region: SLBB; pfam10531
546271002890	comEA protein; Region: comE; TIGR01259
546271002891	Helix-hairpin-helix motif; Region: HHH; pfam00633
546271002892	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
546271002893	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
546271002894	Competence protein; Region: Competence; pfam03772
546271002895	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
546271002896	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
546271002897	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
546271002898	active site
546271002899	5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059
546271002900	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
546271002901	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
546271002902	AIR carboxylase; Region: AIRC; pfam00731
546271002903	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
546271002904	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
546271002905	ATP binding site [chemical binding]; other site
546271002906	active site
546271002907	substrate binding site [chemical binding]; other site
546271002908	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
546271002909	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
546271002910	dimerization interface [polypeptide binding]; other site
546271002911	putative ATP binding site [chemical binding]; other site
546271002912	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
546271002913	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
546271002914	active site
546271002915	substrate binding site [chemical binding]; other site
546271002916	cosubstrate binding site; other site
546271002917	catalytic site [active]
546271002918	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
546271002919	purine monophosphate binding site [chemical binding]; other site
546271002920	dimer interface [polypeptide binding]; other site
546271002921	putative catalytic residues [active]
546271002922	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
546271002923	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
546271002924	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
546271002925	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
546271002926	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
546271002927	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
546271002928	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
546271002929	Peptidase M16C associated; Region: M16C_assoc; pfam08367
546271002930	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
546271002931	dihydrodipicolinate synthase; Region: dapA; TIGR00674
546271002932	dimer interface [polypeptide binding]; other site
546271002933	active site
546271002934	catalytic residue [active]
546271002935	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
546271002936	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
546271002937	Transglycosylase; Region: Transgly; pfam00912
546271002938	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
546271002939	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
546271002940	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
546271002941	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
546271002942	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
546271002943	heterotetramer interface [polypeptide binding]; other site
546271002944	active site pocket [active]
546271002945	cleavage site
546271002946	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
546271002947	feedback inhibition sensing region; other site
546271002948	homohexameric interface [polypeptide binding]; other site
546271002949	carbamate kinase; Reviewed; Region: PRK12686
546271002950	nucleotide binding site [chemical binding]; other site
546271002951	N-acetyl-L-glutamate binding site [chemical binding]; other site
546271002952	acetylornithine aminotransferase; Provisional; Region: PRK02627
546271002953	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
546271002954	inhibitor-cofactor binding pocket; inhibition site
546271002955	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546271002956	catalytic residue [active]
546271002957	ornithine carbamoyltransferase; Provisional; Region: PRK00779
546271002958	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
546271002959	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
546271002960	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
546271002961	argininosuccinate synthase; Provisional; Region: PRK13820
546271002962	ANP binding site [chemical binding]; other site
546271002963	Substrate Binding Site II [chemical binding]; other site
546271002964	Substrate Binding Site I [chemical binding]; other site
546271002965	argininosuccinate lyase; Provisional; Region: PRK00855
546271002966	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
546271002967	active sites [active]
546271002968	tetramer interface [polypeptide binding]; other site
546271002969	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
546271002970	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
546271002971	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
546271002972	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
546271002973	Cl binding site [ion binding]; other site
546271002974	oligomer interface [polypeptide binding]; other site
546271002975	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
546271002976	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
546271002977	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
546271002978	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855
546271002979	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
546271002980	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
546271002981	Protein of unknown function (DUF445); Region: DUF445; pfam04286
546271002982	Protein of unknown function (DUF445); Region: DUF445; pfam04286
546271002983	TPR repeat; Region: TPR_11; pfam13414
546271002984	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546271002985	TPR motif; other site
546271002986	binding surface
546271002987	TPR repeat; Region: TPR_11; pfam13414
546271002988	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546271002989	binding surface
546271002990	TPR repeat; Region: TPR_11; pfam13414
546271002991	TPR motif; other site
546271002992	TPR repeat; Region: TPR_11; pfam13414
546271002993	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546271002994	binding surface
546271002995	TPR motif; other site
546271002996	TPR repeat; Region: TPR_11; pfam13414
546271002997	TPR repeat; Region: TPR_11; pfam13414
546271002998	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
546271002999	binding surface
546271003000	TPR motif; other site
546271003001	S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675
546271003002	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
546271003003	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
546271003004	Surface antigen; Region: Bac_surface_Ag; pfam01103
546271003005	haemagglutination activity domain; Region: Haemagg_act; pfam05860
546271003006	Transposase IS200 like; Region: Y1_Tnp; pfam01797
546271003007	dihydrodipicolinate reductase; Provisional; Region: PRK00048
546271003008	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
546271003009	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
546271003010	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
546271003011	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
546271003012	hypothetical protein; Provisional; Region: PRK05473
546271003013	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
546271003014	Helix-turn-helix domain; Region: HTH_38; pfam13936
546271003015	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
546271003016	Integrase core domain; Region: rve; pfam00665
546271003017	YceG-like family; Region: YceG; pfam02618
546271003018	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
546271003019	dimerization interface [polypeptide binding]; other site
546271003020	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
546271003021	Peptidase family U32; Region: Peptidase_U32; pfam01136
546271003022	Acylphosphatase; Region: Acylphosphatase; pfam00708
546271003023	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
546271003024	Dehydroquinase class II; Region: DHquinase_II; pfam01220
546271003025	active site
546271003026	trimer interface [polypeptide binding]; other site
546271003027	dimer interface [polypeptide binding]; other site
546271003028	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
546271003029	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
546271003030	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
546271003031	active site
546271003032	elongation factor P; Validated; Region: PRK00529
546271003033	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
546271003034	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
546271003035	RNA binding site [nucleotide binding]; other site
546271003036	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
546271003037	RNA binding site [nucleotide binding]; other site
546271003038	Asp23 family; Region: Asp23; pfam03780
546271003039	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
546271003040	putative RNA binding site [nucleotide binding]; other site
546271003041	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
546271003042	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
546271003043	generic binding surface II; other site
546271003044	generic binding surface I; other site
546271003045	Exonuclease VII small subunit [DNA replication, recombination, and repair]; Region: XseB; COG1722
546271003046	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
546271003047	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
546271003048	substrate binding pocket [chemical binding]; other site
546271003049	chain length determination region; other site
546271003050	substrate-Mg2+ binding site; other site
546271003051	catalytic residues [active]
546271003052	aspartate-rich region 1; other site
546271003053	active site lid residues [active]
546271003054	aspartate-rich region 2; other site
546271003055	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
546271003056	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
546271003057	TPP-binding site; other site
546271003058	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
546271003059	PYR/PP interface [polypeptide binding]; other site
546271003060	dimer interface [polypeptide binding]; other site
546271003061	TPP binding site [chemical binding]; other site
546271003062	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
546271003063	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
546271003064	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
546271003065	RNA binding surface [nucleotide binding]; other site
546271003066	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
546271003067	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
546271003068	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708
546271003069	arginine repressor; Provisional; Region: PRK04280
546271003070	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
546271003071	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
546271003072	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
546271003073	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
546271003074	Walker A/P-loop; other site
546271003075	ATP binding site [chemical binding]; other site
546271003076	Q-loop/lid; other site
546271003077	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
546271003078	ABC transporter signature motif; other site
546271003079	Walker B; other site
546271003080	D-loop; other site
546271003081	H-loop/switch region; other site
546271003082	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
546271003083	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
546271003084	dimer interface [polypeptide binding]; other site
546271003085	ADP-ribose binding site [chemical binding]; other site
546271003086	active site
546271003087	nudix motif; other site
546271003088	metal binding site [ion binding]; metal-binding site
546271003089	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
546271003090	Peptidase family M50; Region: Peptidase_M50; pfam02163
546271003091	active site
546271003092	putative substrate binding region [chemical binding]; other site
546271003093	ScpA/B protein; Region: ScpA_ScpB; cl00598
546271003094	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
546271003095	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
546271003096	Peptidase family U32; Region: Peptidase_U32; pfam01136
546271003097	Collagenase; Region: DUF3656; pfam12392
546271003098	Peptidase family U32; Region: Peptidase_U32; pfam01136
546271003099	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
546271003100	MutS domain III; Region: MutS_III; pfam05192
546271003101	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
546271003102	Walker A/P-loop; other site
546271003103	ATP binding site [chemical binding]; other site
546271003104	Q-loop/lid; other site
546271003105	ABC transporter signature motif; other site
546271003106	Walker B; other site
546271003107	D-loop; other site
546271003108	H-loop/switch region; other site
546271003109	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
546271003110	Smr domain; Region: Smr; pfam01713
546271003111	Transglycosylase; Region: Transgly; pfam00912
546271003112	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
546271003113	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
546271003114	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
546271003115	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
546271003116	active site
546271003117	HIGH motif; other site
546271003118	dimer interface [polypeptide binding]; other site
546271003119	KMSKS motif; other site
546271003120	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
546271003121	RNA binding surface [nucleotide binding]; other site
546271003122	hypothetical protein; Validated; Region: PRK00110
546271003123	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
546271003124	active site
546271003125	putative DNA-binding cleft [nucleotide binding]; other site
546271003126	dimer interface [polypeptide binding]; other site
546271003127	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
546271003128	RuvA N terminal domain; Region: RuvA_N; pfam01330
546271003129	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
546271003130	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546271003131	Walker A motif; other site
546271003132	ATP binding site [chemical binding]; other site
546271003133	Walker B motif; other site
546271003134	arginine finger; other site
546271003135	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
546271003136	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which  binds to Adenosine group; Region: Alpha_ANH_like; cd01986
546271003137	Ligand Binding Site [chemical binding]; other site
546271003138	Uncharacterized conserved protein [Function unknown]; Region: COG3589
546271003139	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
546271003140	PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
546271003141	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
546271003142	active site turn [active]
546271003143	phosphorylation site [posttranslational modification]
546271003144	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
546271003145	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
546271003146	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
546271003147	putative active site [active]
546271003148	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
546271003149	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
546271003150	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
546271003151	DNA polymerase I; Provisional; Region: PRK05755
546271003152	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
546271003153	active site
546271003154	metal binding site 1 [ion binding]; metal-binding site
546271003155	putative 5' ssDNA interaction site; other site
546271003156	metal binding site 3; metal-binding site
546271003157	metal binding site 2 [ion binding]; metal-binding site
546271003158	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
546271003159	putative DNA binding site [nucleotide binding]; other site
546271003160	putative metal binding site [ion binding]; other site
546271003161	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
546271003162	active site
546271003163	substrate binding site [chemical binding]; other site
546271003164	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
546271003165	active site
546271003166	DNA binding site [nucleotide binding]
546271003167	catalytic site [active]
546271003168	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
546271003169	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
546271003170	DNA binding site [nucleotide binding]
546271003171	catalytic residue [active]
546271003172	H2TH interface [polypeptide binding]; other site
546271003173	putative catalytic residues [active]
546271003174	turnover-facilitating residue; other site
546271003175	intercalation triad [nucleotide binding]; other site
546271003176	8OG recognition residue [nucleotide binding]; other site
546271003177	putative reading head residues; other site
546271003178	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
546271003179	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
546271003180	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
546271003181	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
546271003182	CoA-binding site [chemical binding]; other site
546271003183	ATP-binding [chemical binding]; other site
546271003184	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
546271003185	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
546271003186	N-acetyl-D-glucosamine binding site [chemical binding]; other site
546271003187	catalytic residue [active]
546271003188	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
546271003189	generic binding surface II; other site
546271003190	generic binding surface I; other site
546271003191	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
546271003192	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
546271003193	active site
546271003194	putative PHP Thumb interface [polypeptide binding]; other site
546271003195	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
546271003196	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328
546271003197	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
546271003198	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546271003199	FeS/SAM binding site; other site
546271003200	TRAM domain; Region: TRAM; cl01282
546271003201	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
546271003202	MutS domain I; Region: MutS_I; pfam01624
546271003203	MutS domain III; Region: MutS_III; pfam05192
546271003204	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
546271003205	Walker A/P-loop; other site
546271003206	ATP binding site [chemical binding]; other site
546271003207	Q-loop/lid; other site
546271003208	ABC transporter signature motif; other site
546271003209	Walker B; other site
546271003210	D-loop; other site
546271003211	H-loop/switch region; other site
546271003212	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
546271003213	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546271003214	ATP binding site [chemical binding]; other site
546271003215	Mg2+ binding site [ion binding]; other site
546271003216	G-X-G motif; other site
546271003217	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
546271003218	ATP binding site [chemical binding]; other site
546271003219	MutL C terminal dimerisation domain; Region: MutL_C; smart00853
546271003220	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546271003221	S-adenosylmethionine binding site [chemical binding]; other site
546271003222	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
546271003223	active site
546271003224	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
546271003225	active site
546271003226	catalytic residues [active]
546271003227	metal binding site [ion binding]; metal-binding site
546271003228	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
546271003229	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
546271003230	putative active site [active]
546271003231	substrate binding site [chemical binding]; other site
546271003232	putative cosubstrate binding site; other site
546271003233	catalytic site [active]
546271003234	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
546271003235	substrate binding site [chemical binding]; other site
546271003236	Protein of unknown function DUF116; Region: DUF116; pfam01976
546271003237	16S rRNA methyltransferase B; Provisional; Region: PRK14902
546271003238	NusB family; Region: NusB; pfam01029
546271003239	putative RNA binding site [nucleotide binding]; other site
546271003240	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546271003241	S-adenosylmethionine binding site [chemical binding]; other site
546271003242	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454
546271003243	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546271003244	FeS/SAM binding site; other site
546271003245	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
546271003246	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
546271003247	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
546271003248	phosphopeptide binding site; other site
546271003249	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
546271003250	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
546271003251	phosphopeptide binding site; other site
546271003252	Protein phosphatase 2C; Region: PP2C; pfam00481
546271003253	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
546271003254	active site
546271003255	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
546271003256	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
546271003257	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
546271003258	Catalytic domain of Protein Kinases; Region: PKc; cd00180
546271003259	active site
546271003260	ATP binding site [chemical binding]; other site
546271003261	substrate binding site [chemical binding]; other site
546271003262	activation loop (A-loop); other site
546271003263	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
546271003264	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
546271003265	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
546271003266	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
546271003267	GTPase RsgA; Reviewed; Region: PRK00098
546271003268	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
546271003269	RNA binding site [nucleotide binding]; other site
546271003270	homodimer interface [polypeptide binding]; other site
546271003271	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
546271003272	GTPase/Zn-binding domain interface [polypeptide binding]; other site
546271003273	GTP/Mg2+ binding site [chemical binding]; other site
546271003274	G4 box; other site
546271003275	G5 box; other site
546271003276	G1 box; other site
546271003277	Switch I region; other site
546271003278	G2 box; other site
546271003279	G3 box; other site
546271003280	Switch II region; other site
546271003281	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
546271003282	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
546271003283	substrate binding site [chemical binding]; other site
546271003284	hexamer interface [polypeptide binding]; other site
546271003285	metal binding site [ion binding]; metal-binding site
546271003286	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
546271003287	Ligand Binding Site [chemical binding]; other site
546271003288	putative GTP cyclohydrolase; Provisional; Region: PRK13674
546271003289	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
546271003290	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
546271003291	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546271003292	dimer interface [polypeptide binding]; other site
546271003293	conserved gate region; other site
546271003294	putative PBP binding loops; other site
546271003295	ABC-ATPase subunit interface; other site
546271003296	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
546271003297	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546271003298	dimer interface [polypeptide binding]; other site
546271003299	conserved gate region; other site
546271003300	putative PBP binding loops; other site
546271003301	ABC-ATPase subunit interface; other site
546271003302	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
546271003303	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490
546271003304	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
546271003305	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
546271003306	Walker A/P-loop; other site
546271003307	ATP binding site [chemical binding]; other site
546271003308	Q-loop/lid; other site
546271003309	ABC transporter signature motif; other site
546271003310	Walker B; other site
546271003311	D-loop; other site
546271003312	H-loop/switch region; other site
546271003313	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
546271003314	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
546271003315	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
546271003316	Walker A/P-loop; other site
546271003317	ATP binding site [chemical binding]; other site
546271003318	Q-loop/lid; other site
546271003319	ABC transporter signature motif; other site
546271003320	Walker B; other site
546271003321	D-loop; other site
546271003322	H-loop/switch region; other site
546271003323	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
546271003324	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
546271003325	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
546271003326	S-layer homology domain; Region: SLH; pfam00395
546271003327	Gram-negative porin; Region: Porin_4; pfam13609
546271003328	Trp repressor protein; Region: Trp_repressor; cl17266
546271003329	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
546271003330	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
546271003331	dimer interface [polypeptide binding]; other site
546271003332	motif 1; other site
546271003333	active site
546271003334	motif 2; other site
546271003335	motif 3; other site
546271003336	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
546271003337	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
546271003338	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
546271003339	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
546271003340	histidinol dehydrogenase; Region: hisD; TIGR00069
546271003341	NAD binding site [chemical binding]; other site
546271003342	dimerization interface [polypeptide binding]; other site
546271003343	product binding site; other site
546271003344	substrate binding site [chemical binding]; other site
546271003345	zinc binding site [ion binding]; other site
546271003346	catalytic residues [active]
546271003347	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
546271003348	putative active site pocket [active]
546271003349	4-fold oligomerization interface [polypeptide binding]; other site
546271003350	metal binding residues [ion binding]; metal-binding site
546271003351	3-fold/trimer interface [polypeptide binding]; other site
546271003352	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
546271003353	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
546271003354	putative active site [active]
546271003355	oxyanion strand; other site
546271003356	catalytic triad [active]
546271003357	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
546271003358	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
546271003359	catalytic residues [active]
546271003360	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
546271003361	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
546271003362	substrate binding site [chemical binding]; other site
546271003363	glutamase interaction surface [polypeptide binding]; other site
546271003364	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
546271003365	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
546271003366	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
546271003367	metal binding site [ion binding]; metal-binding site
546271003368	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
546271003369	putative FMN binding site [chemical binding]; other site
546271003370	NADPH bind site [chemical binding]; other site
546271003371	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869
546271003372	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
546271003373	DRTGG domain; Region: DRTGG; pfam07085
546271003374	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
546271003375	DHHA2 domain; Region: DHHA2; pfam02833
546271003376	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
546271003377	Part of AAA domain; Region: AAA_19; pfam13245
546271003378	Family description; Region: UvrD_C_2; pfam13538
546271003379	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
546271003380	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
546271003381	nucleotide binding pocket [chemical binding]; other site
546271003382	K-X-D-G motif; other site
546271003383	catalytic site [active]
546271003384	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
546271003385	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
546271003386	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
546271003387	Dimer interface [polypeptide binding]; other site
546271003388	BRCT sequence motif; other site
546271003389	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
546271003390	Ligand Binding Site [chemical binding]; other site
546271003391	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
546271003392	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546271003393	FeS/SAM binding site; other site
546271003394	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
546271003395	active site
546271003396	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
546271003397	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
546271003398	DXD motif; other site
546271003399	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
546271003400	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
546271003401	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
546271003402	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
546271003403	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
546271003404	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
546271003405	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
546271003406	active site
546271003407	Riboflavin kinase; Region: Flavokinase; pfam01687
546271003408	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130
546271003409	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
546271003410	RNA binding site [nucleotide binding]; other site
546271003411	active site
546271003412	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
546271003413	DHH family; Region: DHH; pfam01368
546271003414	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
546271003415	translation initiation factor IF-2; Validated; Region: infB; PRK05306
546271003416	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
546271003417	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
546271003418	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
546271003419	G1 box; other site
546271003420	putative GEF interaction site [polypeptide binding]; other site
546271003421	GTP/Mg2+ binding site [chemical binding]; other site
546271003422	Switch I region; other site
546271003423	G2 box; other site
546271003424	G3 box; other site
546271003425	Switch II region; other site
546271003426	G4 box; other site
546271003427	G5 box; other site
546271003428	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
546271003429	Translation-initiation factor 2; Region: IF-2; pfam11987
546271003430	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
546271003431	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
546271003432	putative RNA binding cleft [nucleotide binding]; other site
546271003433	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
546271003434	NusA N-terminal domain; Region: NusA_N; pfam08529
546271003435	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
546271003436	RNA binding site [nucleotide binding]; other site
546271003437	homodimer interface [polypeptide binding]; other site
546271003438	NusA-like KH domain; Region: KH_5; pfam13184
546271003439	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
546271003440	G-X-X-G motif; other site
546271003441	Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576
546271003442	Sm and related proteins; Region: Sm_like; cl00259
546271003443	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
546271003444	putative oligomer interface [polypeptide binding]; other site
546271003445	putative RNA binding site [nucleotide binding]; other site
546271003446	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
546271003447	FAD binding domain; Region: FAD_binding_4; pfam01565
546271003448	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
546271003449	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
546271003450	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
546271003451	6-phosphogluconate dehydratase; Region: edd; TIGR01196
546271003452	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
546271003453	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
546271003454	homodimer interface [polypeptide binding]; other site
546271003455	Walker A motif; other site
546271003456	ATP binding site [chemical binding]; other site
546271003457	hydroxycobalamin binding site [chemical binding]; other site
546271003458	Walker B motif; other site
546271003459	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
546271003460	active site
546271003461	catalytic triad [active]
546271003462	oxyanion hole [active]
546271003463	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
546271003464	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
546271003465	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
546271003466	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
546271003467	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038
546271003468	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
546271003469	active site
546271003470	putative substrate binding pocket [chemical binding]; other site
546271003471	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
546271003472	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
546271003473	homotetramer interface [polypeptide binding]; other site
546271003474	ligand binding site [chemical binding]; other site
546271003475	catalytic site [active]
546271003476	NAD binding site [chemical binding]; other site
546271003477	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
546271003478	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
546271003479	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
546271003480	HlyD family secretion protein; Region: HlyD_3; pfam13437
546271003481	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
546271003482	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
546271003483	motif 1; other site
546271003484	active site
546271003485	motif 2; other site
546271003486	motif 3; other site
546271003487	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
546271003488	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
546271003489	Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969
546271003490	putative active site [active]
546271003491	putative metal binding site [ion binding]; other site
546271003492	Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790
546271003493	endonuclease IV; Provisional; Region: PRK01060
546271003494	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
546271003495	AP (apurinic/apyrimidinic) site pocket; other site
546271003496	DNA interaction; other site
546271003497	Metal-binding active site; metal-binding site
546271003498	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
546271003499	Ligand Binding Site [chemical binding]; other site
546271003500	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
546271003501	polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609
546271003502	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
546271003503	peptide chain release factor 2; Validated; Region: prfB; PRK00578
546271003504	This domain is found in peptide chain release factors; Region: PCRF; smart00937
546271003505	RF-1 domain; Region: RF-1; pfam00472
546271003506	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
546271003507	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
546271003508	ATP binding site [chemical binding]; other site
546271003509	putative Mg++ binding site [ion binding]; other site
546271003510	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
546271003511	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
546271003512	nucleotide binding region [chemical binding]; other site
546271003513	ATP-binding site [chemical binding]; other site
546271003514	SEC-C motif; Region: SEC-C; pfam02810
546271003515	Uncharacterized conserved protein [Function unknown]; Region: COG1284
546271003516	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
546271003517	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
546271003518	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
546271003519	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
546271003520	DNA polymerase III, delta subunit; Region: holA; TIGR01128
546271003521	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
546271003522	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_1; cd12161
546271003523	putative ligand binding site [chemical binding]; other site
546271003524	putative NAD binding site [chemical binding]; other site
546271003525	catalytic site [active]
546271003526	EamA-like transporter family; Region: EamA; pfam00892
546271003527	EamA-like transporter family; Region: EamA; pfam00892
546271003528	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
546271003529	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
546271003530	TPP-binding site [chemical binding]; other site
546271003531	dimer interface [polypeptide binding]; other site
546271003532	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
546271003533	PYR/PP interface [polypeptide binding]; other site
546271003534	dimer interface [polypeptide binding]; other site
546271003535	TPP binding site [chemical binding]; other site
546271003536	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
546271003537	aspartate aminotransferase; Provisional; Region: PRK06836
546271003538	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
546271003539	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546271003540	homodimer interface [polypeptide binding]; other site
546271003541	catalytic residue [active]
546271003542	aspartate kinase; Reviewed; Region: PRK06635
546271003543	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
546271003544	putative nucleotide binding site [chemical binding]; other site
546271003545	putative catalytic residues [active]
546271003546	putative Mg ion binding site [ion binding]; other site
546271003547	putative aspartate binding site [chemical binding]; other site
546271003548	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
546271003549	putative allosteric regulatory site; other site
546271003550	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
546271003551	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
546271003552	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
546271003553	active site
546271003554	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
546271003555	intersubunit interface [polypeptide binding]; other site
546271003556	active site
546271003557	zinc binding site [ion binding]; other site
546271003558	Na+ binding site [ion binding]; other site
546271003559	fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377
546271003560	catalytic residue [active]
546271003561	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823
546271003562	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
546271003563	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
546271003564	Walker A/P-loop; other site
546271003565	ATP binding site [chemical binding]; other site
546271003566	Q-loop/lid; other site
546271003567	ABC transporter signature motif; other site
546271003568	Walker B; other site
546271003569	D-loop; other site
546271003570	H-loop/switch region; other site
546271003571	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
546271003572	Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226
546271003573	Walker A/P-loop; other site
546271003574	ATP binding site [chemical binding]; other site
546271003575	Q-loop/lid; other site
546271003576	ABC transporter signature motif; other site
546271003577	Walker B; other site
546271003578	D-loop; other site
546271003579	H-loop/switch region; other site
546271003580	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
546271003581	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
546271003582	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
546271003583	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
546271003584	Family description; Region: UvrD_C_2; pfam13538
546271003585	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
546271003586	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
546271003587	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
546271003588	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
546271003589	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
546271003590	acyl-activating enzyme (AAE) consensus motif; other site
546271003591	active site
546271003592	AMP binding site [chemical binding]; other site
546271003593	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
546271003594	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
546271003595	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546271003596	S-adenosylmethionine binding site [chemical binding]; other site
546271003597	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
546271003598	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
546271003599	putative dimer interface [polypeptide binding]; other site
546271003600	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
546271003601	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
546271003602	ABC-ATPase subunit  interface; other site
546271003603	dimer interface [polypeptide binding]; other site
546271003604	putative PBP binding regions; other site
546271003605	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
546271003606	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
546271003607	Walker A/P-loop; other site
546271003608	ATP binding site [chemical binding]; other site
546271003609	Q-loop/lid; other site
546271003610	ABC transporter signature motif; other site
546271003611	Walker B; other site
546271003612	D-loop; other site
546271003613	H-loop/switch region; other site
546271003614	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
546271003615	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cd00316
546271003616	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
546271003617	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
546271003618	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
546271003619	Nitrogenase subunit NifH (ATPase) [Inorganic ion transport and metabolism]; Region: NifH; COG1348
546271003620	Nucleotide-binding sites [chemical binding]; other site
546271003621	Walker A motif; other site
546271003622	Switch I region of nucleotide binding site; other site
546271003623	Fe4S4 binding sites [ion binding]; other site
546271003624	Switch II region of nucleotide binding site; other site
546271003625	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
546271003626	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
546271003627	intersubunit interface [polypeptide binding]; other site
546271003628	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
546271003629	CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514
546271003630	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
546271003631	Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955
546271003632	cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
546271003633	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
546271003634	metal ion-dependent adhesion site (MIDAS); other site
546271003635	magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030
546271003636	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546271003637	Walker A motif; other site
546271003638	ATP binding site [chemical binding]; other site
546271003639	Walker B motif; other site
546271003640	arginine finger; other site
546271003641	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
546271003642	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
546271003643	intersubunit interface [polypeptide binding]; other site
546271003644	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546271003645	GeoRSP system radical SAM/SPASM protein; Region: GeoRSP_rSAM; TIGR04303
546271003646	FeS/SAM binding site; other site
546271003647	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
546271003648	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
546271003649	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
546271003650	intersubunit interface [polypeptide binding]; other site
546271003651	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
546271003652	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
546271003653	N-terminal plug; other site
546271003654	ligand-binding site [chemical binding]; other site
546271003655	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546271003656	Radical SAM superfamily; Region: Radical_SAM; pfam04055
546271003657	FeS/SAM binding site; other site
546271003658	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
546271003659	putative active site [active]
546271003660	catalytic residue [active]
546271003661	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
546271003662	A/G-specific adenine glycosylase; Region: mutY; TIGR01084
546271003663	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
546271003664	minor groove reading motif; other site
546271003665	helix-hairpin-helix signature motif; other site
546271003666	substrate binding pocket [chemical binding]; other site
546271003667	active site
546271003668	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
546271003669	DNA binding and oxoG recognition site [nucleotide binding]
546271003670	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
546271003671	active site
546271003672	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
546271003673	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546271003674	motif II; other site
546271003675	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
546271003676	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
546271003677	active site
546271003678	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
546271003679	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546271003680	motif II; other site
546271003681	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
546271003682	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
546271003683	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546271003684	S-adenosylmethionine binding site [chemical binding]; other site
546271003685	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
546271003686	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
546271003687	GatB domain; Region: GatB_Yqey; smart00845
546271003688	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
546271003689	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
546271003690	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
546271003691	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
546271003692	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
546271003693	PYR/PP interface [polypeptide binding]; other site
546271003694	dimer interface [polypeptide binding]; other site
546271003695	TPP binding site [chemical binding]; other site
546271003696	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
546271003697	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
546271003698	TPP-binding site [chemical binding]; other site
546271003699	dimer interface [polypeptide binding]; other site
546271003700	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
546271003701	tartrate dehydrogenase; Region: TTC; TIGR02089
546271003702	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
546271003703	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
546271003704	substrate binding site [chemical binding]; other site
546271003705	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
546271003706	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
546271003707	substrate binding site [chemical binding]; other site
546271003708	ligand binding site [chemical binding]; other site
546271003709	ketol-acid reductoisomerase; Provisional; Region: PRK05479
546271003710	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
546271003711	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
546271003712	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
546271003713	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
546271003714	putative valine binding site [chemical binding]; other site
546271003715	dimer interface [polypeptide binding]; other site
546271003716	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
546271003717	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
546271003718	elongation factor G; Reviewed; Region: PRK12740
546271003719	G1 box; other site
546271003720	putative GEF interaction site [polypeptide binding]; other site
546271003721	GTP/Mg2+ binding site [chemical binding]; other site
546271003722	Switch I region; other site
546271003723	G2 box; other site
546271003724	G3 box; other site
546271003725	Switch II region; other site
546271003726	G4 box; other site
546271003727	G5 box; other site
546271003728	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
546271003729	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
546271003730	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
546271003731	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
546271003732	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
546271003733	active site
546271003734	multimer interface [polypeptide binding]; other site
546271003735	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
546271003736	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
546271003737	trimer interface [polypeptide binding]; other site
546271003738	putative metal binding site [ion binding]; other site
546271003739	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
546271003740	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
546271003741	active site
546271003742	NTP binding site [chemical binding]; other site
546271003743	metal binding triad [ion binding]; metal-binding site
546271003744	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
546271003745	homoserine kinase; Provisional; Region: PRK01212
546271003746	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
546271003747	homoserine dehydrogenase; Provisional; Region: PRK06349
546271003748	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
546271003749	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
546271003750	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
546271003751	hypothetical protein; Provisional; Region: PRK04435
546271003752	C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888
546271003753	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
546271003754	GTP-binding protein Der; Reviewed; Region: PRK00093
546271003755	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
546271003756	G1 box; other site
546271003757	GTP/Mg2+ binding site [chemical binding]; other site
546271003758	Switch I region; other site
546271003759	G2 box; other site
546271003760	Switch II region; other site
546271003761	G3 box; other site
546271003762	G4 box; other site
546271003763	G5 box; other site
546271003764	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
546271003765	G1 box; other site
546271003766	GTP/Mg2+ binding site [chemical binding]; other site
546271003767	Switch I region; other site
546271003768	G2 box; other site
546271003769	G3 box; other site
546271003770	Switch II region; other site
546271003771	G4 box; other site
546271003772	G5 box; other site
546271003773	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
546271003774	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
546271003775	Protein of unknown function (DUF512); Region: DUF512; pfam04459
546271003776	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
546271003777	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
546271003778	RNA binding site [nucleotide binding]; other site
546271003779	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
546271003780	RNA binding site [nucleotide binding]; other site
546271003781	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
546271003782	RNA binding site [nucleotide binding]; other site
546271003783	LytB protein; Region: LYTB; cl00507
546271003784	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
546271003785	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
546271003786	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
546271003787	putative acyl-acceptor binding pocket; other site
546271003788	cytidylate kinase; Provisional; Region: cmk; PRK00023
546271003789	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
546271003790	CMP-binding site; other site
546271003791	The sites determining sugar specificity; other site
546271003792	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
546271003793	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
546271003794	hinge; other site
546271003795	active site
546271003796	flavoprotein, HI0933 family; Region: TIGR00275
546271003797	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
546271003798	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
546271003799	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
546271003800	RNA binding surface [nucleotide binding]; other site
546271003801	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
546271003802	active site
546271003803	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
546271003804	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826
546271003805	active site
546271003806	PHP Thumb interface [polypeptide binding]; other site
546271003807	metal binding site [ion binding]; metal-binding site
546271003808	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
546271003809	generic binding surface II; other site
546271003810	generic binding surface I; other site
546271003811	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546271003812	metal binding site [ion binding]; metal-binding site
546271003813	active site
546271003814	I-site; other site
546271003815	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
546271003816	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
546271003817	serine O-acetyltransferase; Region: cysE; TIGR01172
546271003818	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
546271003819	trimer interface [polypeptide binding]; other site
546271003820	active site
546271003821	substrate binding site [chemical binding]; other site
546271003822	CoA binding site [chemical binding]; other site
546271003823	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
546271003824	Putative esterase; Region: Esterase; pfam00756
546271003825	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
546271003826	benzoate transport; Region: 2A0115; TIGR00895
546271003827	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546271003828	putative substrate translocation pore; other site
546271003829	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546271003830	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
546271003831	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
546271003832	dimer interface [polypeptide binding]; other site
546271003833	active site
546271003834	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
546271003835	catalytic residues [active]
546271003836	substrate binding site [chemical binding]; other site
546271003837	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
546271003838	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
546271003839	NAD(P) binding pocket [chemical binding]; other site
546271003840	agmatinase; Region: agmatinase; TIGR01230
546271003841	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
546271003842	putative active site [active]
546271003843	Mn binding site [ion binding]; other site
546271003844	spermidine synthase; Provisional; Region: PRK00811
546271003845	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546271003846	S-adenosylmethionine binding site [chemical binding]; other site
546271003847	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
546271003848	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
546271003849	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
546271003850	catalytic residue [active]
546271003851	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
546271003852	S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462
546271003853	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
546271003854	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
546271003855	heat shock protein 90; Provisional; Region: PRK05218
546271003856	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546271003857	ATP binding site [chemical binding]; other site
546271003858	Mg2+ binding site [ion binding]; other site
546271003859	G-X-G motif; other site
546271003860	Competence-damaged protein; Region: CinA; pfam02464
546271003861	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
546271003862	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
546271003863	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546271003864	FeS/SAM binding site; other site
546271003865	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
546271003866	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
546271003867	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
546271003868	Domain of unknown function (DUF814); Region: DUF814; pfam05670
546271003869	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
546271003870	trimer interface [polypeptide binding]; other site
546271003871	active site
546271003872	bacterial Hfq-like; Region: Hfq; cd01716
546271003873	hexamer interface [polypeptide binding]; other site
546271003874	Sm1 motif; other site
546271003875	RNA binding site [nucleotide binding]; other site
546271003876	Sm2 motif; other site
546271003877	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
546271003878	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
546271003879	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
546271003880	metal-dependent hydrolase; Provisional; Region: PRK00685
546271003881	Thiamine pyrophosphokinase; Region: TPK; cd07995
546271003882	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
546271003883	active site
546271003884	dimerization interface [polypeptide binding]; other site
546271003885	thiamine binding site [chemical binding]; other site
546271003886	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
546271003887	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
546271003888	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
546271003889	23S rRNA binding site [nucleotide binding]; other site
546271003890	L21 binding site [polypeptide binding]; other site
546271003891	L13 binding site [polypeptide binding]; other site
546271003892	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
546271003893	translation initiation factor IF-3; Region: infC; TIGR00168
546271003894	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
546271003895	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
546271003896	Cell division protein ZapA; Region: ZapA; pfam05164
546271003897	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
546271003898	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
546271003899	putative tRNA-binding site [nucleotide binding]; other site
546271003900	B3/4 domain; Region: B3_4; pfam03483
546271003901	tRNA synthetase B5 domain; Region: B5; smart00874
546271003902	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
546271003903	dimer interface [polypeptide binding]; other site
546271003904	motif 1; other site
546271003905	motif 3; other site
546271003906	motif 2; other site
546271003907	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
546271003908	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
546271003909	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
546271003910	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
546271003911	dimer interface [polypeptide binding]; other site
546271003912	motif 1; other site
546271003913	active site
546271003914	motif 2; other site
546271003915	motif 3; other site
546271003916	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
546271003917	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
546271003918	intersubunit interface [polypeptide binding]; other site
546271003919	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
546271003920	Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799
546271003921	DNA binding site [nucleotide binding]
546271003922	dimer interface [polypeptide binding]; other site
546271003923	active site
546271003924	Int/Topo IB signature motif; other site
546271003925	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
546271003926	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
546271003927	Zn2+ binding site [ion binding]; other site
546271003928	Mg2+ binding site [ion binding]; other site
546271003929	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
546271003930	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
546271003931	homodimer interaction site [polypeptide binding]; other site
546271003932	cofactor binding site; other site
546271003933	Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060
546271003934	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
546271003935	active site
546271003936	HIGH motif; other site
546271003937	nucleotide binding site [chemical binding]; other site
546271003938	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
546271003939	active site
546271003940	KMSKS motif; other site
546271003941	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
546271003942	tRNA binding surface [nucleotide binding]; other site
546271003943	anticodon binding site; other site
546271003944	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
546271003945	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
546271003946	chain length determinant protein WzzB; Provisional; Region: PRK15471
546271003947	Predicted membrane protein [Function unknown]; Region: COG1297
546271003948	putative oligopeptide transporter, OPT family; Region: TIGR00733
546271003949	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
546271003950	RelB antitoxin; Region: RelB; cl01171
546271003951	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
546271003952	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
546271003953	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
546271003954	protein binding site [polypeptide binding]; other site
546271003955	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
546271003956	Catalytic dyad [active]
546271003957	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
546271003958	Peptidase family M23; Region: Peptidase_M23; pfam01551
546271003959	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
546271003960	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
546271003961	FtsX-like permease family; Region: FtsX; pfam02687
546271003962	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
546271003963	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546271003964	Walker A/P-loop; other site
546271003965	ATP binding site [chemical binding]; other site
546271003966	Q-loop/lid; other site
546271003967	ABC transporter signature motif; other site
546271003968	Walker B; other site
546271003969	D-loop; other site
546271003970	H-loop/switch region; other site
546271003971	6-phosphofructokinase [Carbohydrate transport and metabolism]; Region: PfkA; COG0205
546271003972	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
546271003973	dimerization interface [polypeptide binding]; other site
546271003974	allosteric effector site; other site
546271003975	active site
546271003976	ADP/pyrophosphate binding site [chemical binding]; other site
546271003977	fructose-1,6-bisphosphate binding site; other site
546271003978	aspartate aminotransferase; Provisional; Region: PRK06836
546271003979	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
546271003980	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546271003981	homodimer interface [polypeptide binding]; other site
546271003982	catalytic residue [active]
546271003983	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
546271003984	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
546271003985	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
546271003986	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
546271003987	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
546271003988	G1 box; other site
546271003989	GTP/Mg2+ binding site [chemical binding]; other site
546271003990	Switch I region; other site
546271003991	G2 box; other site
546271003992	G3 box; other site
546271003993	Switch II region; other site
546271003994	G4 box; other site
546271003995	G5 box; other site
546271003996	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
546271003997	Found in ATP-dependent protease La (LON); Region: LON; smart00464
546271003998	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546271003999	Walker A motif; other site
546271004000	ATP binding site [chemical binding]; other site
546271004001	Walker B motif; other site
546271004002	arginine finger; other site
546271004003	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
546271004004	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
546271004005	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
546271004006	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546271004007	Walker A motif; other site
546271004008	ATP binding site [chemical binding]; other site
546271004009	Walker B motif; other site
546271004010	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
546271004011	Clp protease; Region: CLP_protease; pfam00574
546271004012	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
546271004013	oligomer interface [polypeptide binding]; other site
546271004014	active site residues [active]
546271004015	trigger factor; Provisional; Region: tig; PRK01490
546271004016	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
546271004017	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
546271004018	Uncharacterized conserved protein [Function unknown]; Region: COG0398
546271004019	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
546271004020	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
546271004021	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
546271004022	active site
546271004023	metal binding site [ion binding]; metal-binding site
546271004024	Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917
546271004025	Protein of unknown function (DUF2612); Region: DUF2612; pfam11041
546271004026	Baseplate J-like protein; Region: Baseplate_J; cl01294
546271004027	PAAR motif; Region: PAAR_motif; pfam05488
546271004028	Protein of unknown function (DUF3277); Region: DUF3277; pfam11681
546271004029	Protein of unknown function (DUF3383); Region: DUF3383; pfam11863
546271004030	Protein of unknown function (DUF4054); Region: DUF4054; pfam13262
546271004031	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834
546271004032	Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950
546271004033	Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979
546271004034	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
546271004035	Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206
546271004036	phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555
546271004037	Protein of unknown function (DUF1073); Region: DUF1073; pfam06381
546271004038	Phage terminase large subunit; Region: Terminase_3; cl12054
546271004039	Terminase-like family; Region: Terminase_6; pfam03237
546271004040	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
546271004041	Prophage antirepressor [Transcription]; Region: COG3617
546271004042	BRO family, N-terminal domain; Region: Bro-N; smart01040
546271004043	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
546271004044	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
546271004045	non-specific DNA binding site [nucleotide binding]; other site
546271004046	salt bridge; other site
546271004047	sequence-specific DNA binding site [nucleotide binding]; other site
546271004048	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
546271004049	Endodeoxyribonuclease RusA; Region: RusA; cl01885
546271004050	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
546271004051	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
546271004052	dimer interface [polypeptide binding]; other site
546271004053	ssDNA binding site [nucleotide binding]; other site
546271004054	tetramer (dimer of dimers) interface [polypeptide binding]; other site
546271004055	Domain of unknown function (DUF4406); Region: DUF4406; pfam14359
546271004056	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
546271004057	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546271004058	Walker A motif; other site
546271004059	ATP binding site [chemical binding]; other site
546271004060	Walker B motif; other site
546271004061	arginine finger; other site
546271004062	N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; cl09889
546271004063	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
546271004064	RecT family; Region: RecT; cl04285
546271004065	YqaJ-like viral recombinase domain; Region: YqaJ; cl09232
546271004066	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
546271004067	Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035
546271004068	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
546271004069	non-specific DNA binding site [nucleotide binding]; other site
546271004070	salt bridge; other site
546271004071	sequence-specific DNA binding site [nucleotide binding]; other site
546271004072	PemK-like protein; Region: PemK; pfam02452
546271004073	Domain of unknown function (DUF955); Region: DUF955; pfam06114
546271004074	PemK-like protein; Region: PemK; pfam02452
546271004075	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
546271004076	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
546271004077	Int/Topo IB signature motif; other site
546271004078	putative lipid kinase; Reviewed; Region: PRK13059
546271004079	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
546271004080	stage V sporulation protein B; Region: spore_V_B; TIGR02900
546271004081	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
546271004082	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
546271004083	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
546271004084	nucleotide binding site/active site [active]
546271004085	HIT family signature motif; other site
546271004086	catalytic residue [active]
546271004087	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
546271004088	putative active site [active]
546271004089	dimerization interface [polypeptide binding]; other site
546271004090	putative tRNAtyr binding site [nucleotide binding]; other site
546271004091	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
546271004092	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
546271004093	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
546271004094	2-isopropylmalate synthase; Validated; Region: PRK03739
546271004095	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
546271004096	active site
546271004097	catalytic residues [active]
546271004098	metal binding site [ion binding]; metal-binding site
546271004099	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
546271004100	antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870
546271004101	toxin interface [polypeptide binding]; other site
546271004102	Zn binding site [ion binding]; other site
546271004103	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
546271004104	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
546271004105	active site
546271004106	HIGH motif; other site
546271004107	dimer interface [polypeptide binding]; other site
546271004108	KMSKS motif; other site
546271004109	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
546271004110	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
546271004111	ATP binding site [chemical binding]; other site
546271004112	substrate interface [chemical binding]; other site
546271004113	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
546271004114	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
546271004115	N-terminal plug; other site
546271004116	ligand-binding site [chemical binding]; other site
546271004117	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
546271004118	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
546271004119	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
546271004120	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
546271004121	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
546271004122	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
546271004123	intersubunit interface [polypeptide binding]; other site
546271004124	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
546271004125	putative active site [active]
546271004126	Asp23 family; Region: Asp23; pfam03780
546271004127	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
546271004128	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
546271004129	active site
546271004130	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
546271004131	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
546271004132	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
546271004133	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
546271004134	putative active site [active]
546271004135	metal binding site [ion binding]; metal-binding site
546271004136	homodimer binding site [polypeptide binding]; other site
546271004137	phosphodiesterase; Provisional; Region: PRK12704
546271004138	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
546271004139	Zn2+ binding site [ion binding]; other site
546271004140	Mg2+ binding site [ion binding]; other site
546271004141	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
546271004142	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
546271004143	Ligand Binding Site [chemical binding]; other site
546271004144	hypothetical protein; Provisional; Region: PRK04194
546271004145	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
546271004146	AIR carboxylase; Region: AIRC; smart01001
546271004147	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
546271004148	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
546271004149	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
546271004150	active site
546271004151	(T/H)XGH motif; other site
546271004152	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
546271004153	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546271004154	S-adenosylmethionine binding site [chemical binding]; other site
546271004155	Protein of unknown function (DUF4127); Region: DUF4127; pfam13552
546271004156	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
546271004157	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
546271004158	M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659
546271004159	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
546271004160	oligomer interface [polypeptide binding]; other site
546271004161	putative active site [active]
546271004162	metal binding site [ion binding]; metal-binding site
546271004163	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
546271004164	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
546271004165	FMN binding site [chemical binding]; other site
546271004166	active site
546271004167	catalytic residues [active]
546271004168	substrate binding site [chemical binding]; other site
546271004169	pantothenate kinase; Reviewed; Region: PRK13318
546271004170	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
546271004171	putative DNA binding site [nucleotide binding]; other site
546271004172	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
546271004173	putative Zn2+ binding site [ion binding]; other site
546271004174	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
546271004175	FtsH Extracellular; Region: FtsH_ext; pfam06480
546271004176	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
546271004177	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546271004178	Walker A motif; other site
546271004179	ATP binding site [chemical binding]; other site
546271004180	Walker B motif; other site
546271004181	arginine finger; other site
546271004182	Peptidase family M41; Region: Peptidase_M41; pfam01434
546271004183	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
546271004184	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
546271004185	Walker A/P-loop; other site
546271004186	ATP binding site [chemical binding]; other site
546271004187	Q-loop/lid; other site
546271004188	ABC transporter signature motif; other site
546271004189	Walker B; other site
546271004190	D-loop; other site
546271004191	H-loop/switch region; other site
546271004192	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
546271004193	Domain of unknown function (DUF4418); Region: DUF4418; pfam14387
546271004194	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
546271004195	Zn2+ binding site [ion binding]; other site
546271004196	Mg2+ binding site [ion binding]; other site
546271004197	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
546271004198	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
546271004199	Zn2+ binding site [ion binding]; other site
546271004200	Mg2+ binding site [ion binding]; other site
546271004201	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
546271004202	Zn2+ binding site [ion binding]; other site
546271004203	Mg2+ binding site [ion binding]; other site
546271004204	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
546271004205	Clp amino terminal domain; Region: Clp_N; pfam02861
546271004206	Clp amino terminal domain; Region: Clp_N; pfam02861
546271004207	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546271004208	Walker A motif; other site
546271004209	ATP binding site [chemical binding]; other site
546271004210	Walker B motif; other site
546271004211	arginine finger; other site
546271004212	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546271004213	Walker A motif; other site
546271004214	ATP binding site [chemical binding]; other site
546271004215	Walker B motif; other site
546271004216	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
546271004217	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
546271004218	Cobalt chelatase (CbiK); Region: CbiK; pfam06180
546271004219	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
546271004220	active site
546271004221	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
546271004222	active site
546271004223	N-terminal domain interface [polypeptide binding]; other site
546271004224	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
546271004225	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
546271004226	metal-binding site [ion binding]
546271004227	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
546271004228	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546271004229	motif II; other site
546271004230	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
546271004231	metal-binding site [ion binding]
546271004232	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
546271004233	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
546271004234	metal binding site [ion binding]; metal-binding site
546271004235	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
546271004236	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
546271004237	Walker A/P-loop; other site
546271004238	ATP binding site [chemical binding]; other site
546271004239	Q-loop/lid; other site
546271004240	ABC transporter signature motif; other site
546271004241	Walker B; other site
546271004242	D-loop; other site
546271004243	H-loop/switch region; other site
546271004244	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
546271004245	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
546271004246	Walker A/P-loop; other site
546271004247	ATP binding site [chemical binding]; other site
546271004248	Q-loop/lid; other site
546271004249	ABC transporter signature motif; other site
546271004250	Walker B; other site
546271004251	D-loop; other site
546271004252	H-loop/switch region; other site
546271004253	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
546271004254	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546271004255	dimer interface [polypeptide binding]; other site
546271004256	conserved gate region; other site
546271004257	putative PBP binding loops; other site
546271004258	ABC-ATPase subunit interface; other site
546271004259	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
546271004260	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546271004261	dimer interface [polypeptide binding]; other site
546271004262	conserved gate region; other site
546271004263	putative PBP binding loops; other site
546271004264	ABC-ATPase subunit interface; other site
546271004265	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
546271004266	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518
546271004267	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
546271004268	homodimer interface [polypeptide binding]; other site
546271004269	metal binding site [ion binding]; metal-binding site
546271004270	Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139
546271004271	putative FMN binding site [chemical binding]; other site
546271004272	beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555
546271004273	CTP synthetase; Validated; Region: pyrG; PRK05380
546271004274	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
546271004275	Catalytic site [active]
546271004276	active site
546271004277	UTP binding site [chemical binding]; other site
546271004278	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
546271004279	active site
546271004280	putative oxyanion hole; other site
546271004281	catalytic triad [active]
546271004282	DNA-directed RNA polymerase subunit delta; Reviewed; Region: PRK02363
546271004283	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
546271004284	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
546271004285	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
546271004286	active site
546271004287	HIGH motif; other site
546271004288	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
546271004289	KMSK motif region; other site
546271004290	tRNA binding surface [nucleotide binding]; other site
546271004291	DALR anticodon binding domain; Region: DALR_1; smart00836
546271004292	anticodon binding site; other site
546271004293	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
546271004294	Cupin superfamily (DUF985); Region: Cupin_5; cl01418
546271004295	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
546271004296	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
546271004297	active site
546271004298	nucleophile elbow; other site
546271004299	prolyl-tRNA synthetase; Provisional; Region: PRK09194
546271004300	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
546271004301	dimer interface [polypeptide binding]; other site
546271004302	motif 1; other site
546271004303	active site
546271004304	motif 2; other site
546271004305	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
546271004306	putative deacylase active site [active]
546271004307	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
546271004308	active site
546271004309	motif 3; other site
546271004310	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
546271004311	anticodon binding site; other site
546271004312	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
546271004313	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
546271004314	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
546271004315	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
546271004316	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
546271004317	active site
546271004318	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
546271004319	protein binding site [polypeptide binding]; other site
546271004320	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
546271004321	putative substrate binding region [chemical binding]; other site
546271004322	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
546271004323	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
546271004324	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
546271004325	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
546271004326	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
546271004327	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
546271004328	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
546271004329	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
546271004330	catalytic residue [active]
546271004331	putative FPP diphosphate  binding site; other site
546271004332	putative FPP binding hydrophobic cleft; other site
546271004333	dimer interface [polypeptide binding]; other site
546271004334	putative IPP diphosphate binding site; other site
546271004335	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
546271004336	primosomal protein N' Region: priA; TIGR00595
546271004337	ATP binding site [chemical binding]; other site
546271004338	putative Mg++ binding site [ion binding]; other site
546271004339	helicase superfamily c-terminal domain; Region: HELICc; smart00490
546271004340	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
546271004341	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
546271004342	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
546271004343	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
546271004344	RimM N-terminal domain; Region: RimM; pfam01782
546271004345	PRC-barrel domain; Region: PRC; pfam05239
546271004346	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
546271004347	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
546271004348	hypothetical protein; Provisional; Region: PRK00468
546271004349	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
546271004350	signal recognition particle protein; Provisional; Region: PRK10867
546271004351	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
546271004352	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
546271004353	P loop; other site
546271004354	GTP binding site [chemical binding]; other site
546271004355	Signal peptide binding domain; Region: SRP_SPB; pfam02978
546271004356	putative DNA-binding protein; Validated; Region: PRK00118
546271004357	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
546271004358	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
546271004359	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
546271004360	dimer interface [polypeptide binding]; other site
546271004361	putative anticodon binding site; other site
546271004362	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
546271004363	motif 1; other site
546271004364	active site
546271004365	motif 2; other site
546271004366	motif 3; other site
546271004367	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
546271004368	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
546271004369	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
546271004370	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
546271004371	GIY-YIG motif/motif A; other site
546271004372	putative active site [active]
546271004373	putative metal binding site [ion binding]; other site
546271004374	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
546271004375	active site
546271004376	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
546271004377	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
546271004378	Fic family protein [Function unknown]; Region: COG3177
546271004379	Fic/DOC family; Region: Fic; pfam02661
546271004380	Domain of unknown function (DUF1848); Region: DUF1848; pfam08902
546271004381	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
546271004382	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
546271004383	homodimer interface [polypeptide binding]; other site
546271004384	substrate-cofactor binding pocket; other site
546271004385	catalytic residue [active]
546271004386	Autotransporter beta-domain; Region: Autotransporter; pfam03797
546271004387	Methyltransferase domain; Region: Methyltransf_31; pfam13847
546271004388	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546271004389	S-adenosylmethionine binding site [chemical binding]; other site
546271004390	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
546271004391	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
546271004392	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
546271004393	alphaNTD - beta interaction site [polypeptide binding]; other site
546271004394	alphaNTD homodimer interface [polypeptide binding]; other site
546271004395	alphaNTD - beta' interaction site [polypeptide binding]; other site
546271004396	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
546271004397	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
546271004398	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
546271004399	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
546271004400	RNA binding surface [nucleotide binding]; other site
546271004401	30S ribosomal protein S11; Validated; Region: PRK05309
546271004402	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
546271004403	30S ribosomal protein S13; Region: bact_S13; TIGR03631
546271004404	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
546271004405	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
546271004406	rRNA binding site [nucleotide binding]; other site
546271004407	predicted 30S ribosome binding site; other site
546271004408	adenylate kinase; Reviewed; Region: adk; PRK00279
546271004409	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
546271004410	AMP-binding site [chemical binding]; other site
546271004411	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
546271004412	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
546271004413	SecY translocase; Region: SecY; pfam00344
546271004414	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
546271004415	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
546271004416	23S rRNA binding site [nucleotide binding]; other site
546271004417	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
546271004418	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
546271004419	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
546271004420	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
546271004421	5S rRNA interface [nucleotide binding]; other site
546271004422	L27 interface [polypeptide binding]; other site
546271004423	23S rRNA interface [nucleotide binding]; other site
546271004424	L5 interface [polypeptide binding]; other site
546271004425	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
546271004426	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
546271004427	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
546271004428	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
546271004429	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
546271004430	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
546271004431	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
546271004432	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
546271004433	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
546271004434	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
546271004435	RNA binding site [nucleotide binding]; other site
546271004436	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
546271004437	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
546271004438	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
546271004439	23S rRNA interface [nucleotide binding]; other site
546271004440	putative translocon interaction site; other site
546271004441	signal recognition particle (SRP54) interaction site; other site
546271004442	L23 interface [polypeptide binding]; other site
546271004443	trigger factor interaction site; other site
546271004444	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
546271004445	23S rRNA interface [nucleotide binding]; other site
546271004446	5S rRNA interface [nucleotide binding]; other site
546271004447	putative antibiotic binding site [chemical binding]; other site
546271004448	L25 interface [polypeptide binding]; other site
546271004449	L27 interface [polypeptide binding]; other site
546271004450	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
546271004451	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
546271004452	G-X-X-G motif; other site
546271004453	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
546271004454	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
546271004455	putative translocon binding site; other site
546271004456	protein-rRNA interface [nucleotide binding]; other site
546271004457	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
546271004458	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
546271004459	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
546271004460	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
546271004461	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
546271004462	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
546271004463	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
546271004464	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
546271004465	elongation factor Tu; Reviewed; Region: PRK00049
546271004466	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
546271004467	G1 box; other site
546271004468	GEF interaction site [polypeptide binding]; other site
546271004469	GTP/Mg2+ binding site [chemical binding]; other site
546271004470	Switch I region; other site
546271004471	G2 box; other site
546271004472	G3 box; other site
546271004473	Switch II region; other site
546271004474	G4 box; other site
546271004475	G5 box; other site
546271004476	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
546271004477	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
546271004478	Antibiotic Binding Site [chemical binding]; other site
546271004479	elongation factor G; Reviewed; Region: PRK00007
546271004480	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
546271004481	G1 box; other site
546271004482	putative GEF interaction site [polypeptide binding]; other site
546271004483	GTP/Mg2+ binding site [chemical binding]; other site
546271004484	Switch I region; other site
546271004485	G2 box; other site
546271004486	G3 box; other site
546271004487	Switch II region; other site
546271004488	G4 box; other site
546271004489	G5 box; other site
546271004490	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
546271004491	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
546271004492	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
546271004493	30S ribosomal protein S7; Validated; Region: PRK05302
546271004494	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
546271004495	S17 interaction site [polypeptide binding]; other site
546271004496	S8 interaction site; other site
546271004497	16S rRNA interaction site [nucleotide binding]; other site
546271004498	streptomycin interaction site [chemical binding]; other site
546271004499	23S rRNA interaction site [nucleotide binding]; other site
546271004500	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
546271004501	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
546271004502	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
546271004503	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
546271004504	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
546271004505	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
546271004506	active site
546271004507	metal binding site [ion binding]; metal-binding site
546271004508	homotetramer interface [polypeptide binding]; other site
546271004509	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
546271004510	homopentamer interface [polypeptide binding]; other site
546271004511	active site
546271004512	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
546271004513	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140
546271004514	conserved cys residue [active]
546271004515	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
546271004516	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
546271004517	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
546271004518	dimerization interface [polypeptide binding]; other site
546271004519	active site
546271004520	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
546271004521	Lumazine binding domain; Region: Lum_binding; pfam00677
546271004522	Lumazine binding domain; Region: Lum_binding; pfam00677
546271004523	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
546271004524	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
546271004525	catalytic motif [active]
546271004526	Zn binding site [ion binding]; other site
546271004527	RibD C-terminal domain; Region: RibD_C; cl17279
546271004528	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
546271004529	NlpC/P60 family; Region: NLPC_P60; pfam00877
546271004530	Uncharacterized conserved protein [Function unknown]; Region: COG0327
546271004531	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
546271004532	Family of unknown function (DUF633); Region: DUF633; pfam04816
546271004533	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
546271004534	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
546271004535	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
546271004536	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
546271004537	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
546271004538	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
546271004539	DNA binding residues [nucleotide binding]
546271004540	DNA primase; Validated; Region: dnaG; PRK05667
546271004541	CHC2 zinc finger; Region: zf-CHC2; pfam01807
546271004542	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
546271004543	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
546271004544	active site
546271004545	metal binding site [ion binding]; metal-binding site
546271004546	interdomain interaction site; other site
546271004547	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
546271004548	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
546271004549	Zn2+ binding site [ion binding]; other site
546271004550	Mg2+ binding site [ion binding]; other site
546271004551	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
546271004552	OstA-like protein; Region: OstA; cl00844
546271004553	Domain of unknown function (DUF389); Region: DUF389; pfam04087
546271004554	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
546271004555	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
546271004556	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546271004557	catalytic residue [active]
546271004558	Peptidase family M48; Region: Peptidase_M48; cl12018
546271004559	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
546271004560	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
546271004561	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
546271004562	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
546271004563	Repair protein; Region: Repair_PSII; pfam04536
546271004564	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
546271004565	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
546271004566	putative active site [active]
546271004567	putative metal binding site [ion binding]; other site
546271004568	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
546271004569	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
546271004570	putative dimer interface [polypeptide binding]; other site
546271004571	[2Fe-2S] cluster binding site [ion binding]; other site
546271004572	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
546271004573	SLBB domain; Region: SLBB; pfam10531
546271004574	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
546271004575	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
546271004576	catalytic loop [active]
546271004577	iron binding site [ion binding]; other site
546271004578	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
546271004579	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
546271004580	4Fe-4S binding domain; Region: Fer4; pfam00037
546271004581	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
546271004582	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
546271004583	Uncharacterized conserved protein [Function unknown]; Region: COG2966
546271004584	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
546271004585	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
546271004586	Uncharacterized conserved protein [Function unknown]; Region: COG2966
546271004587	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
546271004588	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
546271004589	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546271004590	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
546271004591	active site
546271004592	phosphorylation site [posttranslational modification]
546271004593	intermolecular recognition site; other site
546271004594	dimerization interface [polypeptide binding]; other site
546271004595	LytTr DNA-binding domain; Region: LytTR; smart00850
546271004596	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
546271004597	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
546271004598	CoA binding domain; Region: CoA_binding; smart00881
546271004599	CoA-ligase; Region: Ligase_CoA; pfam00549
546271004600	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
546271004601	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
546271004602	CoA-ligase; Region: Ligase_CoA; pfam00549
546271004603	KpsF/GutQ family protein; Region: kpsF; TIGR00393
546271004604	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
546271004605	putative active site [active]
546271004606	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
546271004607	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
546271004608	Carbon starvation protein CstA; Region: CstA; pfam02554
546271004609	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
546271004610	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
546271004611	G1 box; other site
546271004612	GTP/Mg2+ binding site [chemical binding]; other site
546271004613	G2 box; other site
546271004614	Switch I region; other site
546271004615	G3 box; other site
546271004616	Switch II region; other site
546271004617	G4 box; other site
546271004618	G5 box; other site
546271004619	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
546271004620	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
546271004621	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546271004622	FeS/SAM binding site; other site
546271004623	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
546271004624	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546271004625	FeS/SAM binding site; other site
546271004626	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
546271004627	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
546271004628	G1 box; other site
546271004629	GTP/Mg2+ binding site [chemical binding]; other site
546271004630	G2 box; other site
546271004631	Switch I region; other site
546271004632	G3 box; other site
546271004633	Switch II region; other site
546271004634	G4 box; other site
546271004635	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
546271004636	G1 box; other site
546271004637	GTP/Mg2+ binding site [chemical binding]; other site
546271004638	G2 box; other site
546271004639	Switch I region; other site
546271004640	G3 box; other site
546271004641	Switch II region; other site
546271004642	G4 box; other site
546271004643	G5 box; other site
546271004644	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
546271004645	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
546271004646	non-specific DNA binding site [nucleotide binding]; other site
546271004647	salt bridge; other site
546271004648	sequence-specific DNA binding site [nucleotide binding]; other site
546271004649	Catalytic domain of Protein Kinases; Region: PKc; cd00180
546271004650	active site
546271004651	ATP binding site [chemical binding]; other site
546271004652	substrate binding site [chemical binding]; other site
546271004653	activation loop (A-loop); other site
546271004654	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
546271004655	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
546271004656	HAMP domain; Region: HAMP; pfam00672
546271004657	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
546271004658	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
546271004659	dimer interface [polypeptide binding]; other site
546271004660	putative CheW interface [polypeptide binding]; other site
546271004661	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
546271004662	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
546271004663	FtsX-like permease family; Region: FtsX; pfam02687
546271004664	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
546271004665	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
546271004666	Walker A/P-loop; other site
546271004667	ATP binding site [chemical binding]; other site
546271004668	Q-loop/lid; other site
546271004669	ABC transporter signature motif; other site
546271004670	Walker B; other site
546271004671	D-loop; other site
546271004672	H-loop/switch region; other site
546271004673	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
546271004674	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
546271004675	HlyD family secretion protein; Region: HlyD_3; pfam13437
546271004676	Outer membrane efflux protein; Region: OEP; pfam02321
546271004677	Outer membrane efflux protein; Region: OEP; pfam02321
546271004678	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
546271004679	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
546271004680	ATP binding site [chemical binding]; other site
546271004681	putative Mg++ binding site [ion binding]; other site
546271004682	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
546271004683	nucleotide binding region [chemical binding]; other site
546271004684	ATP-binding site [chemical binding]; other site
546271004685	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
546271004686	HRDC domain; Region: HRDC; pfam00570
546271004687	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546271004688	putative substrate translocation pore; other site
546271004689	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
546271004690	uracil transporter; Provisional; Region: PRK10720
546271004691	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
546271004692	Na2 binding site [ion binding]; other site
546271004693	putative substrate binding site 1 [chemical binding]; other site
546271004694	Na binding site 1 [ion binding]; other site
546271004695	putative substrate binding site 2 [chemical binding]; other site
546271004696	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
546271004697	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
546271004698	trimer interface [polypeptide binding]; other site
546271004699	putative metal binding site [ion binding]; other site
546271004700	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
546271004701	Recombination protein O N terminal; Region: RecO_N; pfam11967
546271004702	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
546271004703	Recombination protein O C terminal; Region: RecO_C; pfam02565
546271004704	Uncharacterized conserved protein [Function unknown]; Region: COG2928
546271004705	GTPase Era; Reviewed; Region: era; PRK00089
546271004706	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
546271004707	G1 box; other site
546271004708	GTP/Mg2+ binding site [chemical binding]; other site
546271004709	Switch I region; other site
546271004710	G2 box; other site
546271004711	Switch II region; other site
546271004712	G3 box; other site
546271004713	G4 box; other site
546271004714	G5 box; other site
546271004715	KH domain; Region: KH_2; pfam07650
546271004716	metal-binding heat shock protein; Provisional; Region: PRK00016
546271004717	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
546271004718	PhoH-like protein; Region: PhoH; pfam02562
546271004719	biotin synthase; Region: bioB; TIGR00433
546271004720	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546271004721	FeS/SAM binding site; other site
546271004722	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
546271004723	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
546271004724	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
546271004725	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
546271004726	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
546271004727	Uncharacterized conserved protein [Function unknown]; Region: COG1284
546271004728	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
546271004729	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
546271004730	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
546271004731	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
546271004732	Ligand binding site; other site
546271004733	Putative Catalytic site; other site
546271004734	DXD motif; other site
546271004735	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546271004736	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
546271004737	dimer interface [polypeptide binding]; other site
546271004738	phosphorylation site [posttranslational modification]
546271004739	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546271004740	ATP binding site [chemical binding]; other site
546271004741	Mg2+ binding site [ion binding]; other site
546271004742	G-X-G motif; other site
546271004743	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
546271004744	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546271004745	active site
546271004746	phosphorylation site [posttranslational modification]
546271004747	intermolecular recognition site; other site
546271004748	dimerization interface [polypeptide binding]; other site
546271004749	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
546271004750	DNA binding site [nucleotide binding]
546271004751	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
546271004752	synthetase active site [active]
546271004753	NTP binding site [chemical binding]; other site
546271004754	metal binding site [ion binding]; metal-binding site
546271004755	cell division protein FtsW; Region: ftsW; TIGR02614
546271004756	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546271004757	S-adenosylmethionine binding site [chemical binding]; other site
546271004758	phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608
546271004759	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546271004760	Walker A motif; other site
546271004761	ATP binding site [chemical binding]; other site
546271004762	Walker B motif; other site
546271004763	arginine finger; other site
546271004764	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
546271004765	Divergent AAA domain; Region: AAA_4; pfam04326
546271004766	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
546271004767	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
546271004768	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
546271004769	Walker A motif; other site
546271004770	ATP binding site [chemical binding]; other site
546271004771	Walker B motif; other site
546271004772	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
546271004773	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546271004774	putative active site [active]
546271004775	PAS fold; Region: PAS_3; pfam08447
546271004776	heme pocket [chemical binding]; other site
546271004777	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546271004778	metal binding site [ion binding]; metal-binding site
546271004779	active site
546271004780	I-site; other site
546271004781	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
546271004782	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
546271004783	DctM-like transporters; Region: DctM; pfam06808
546271004784	Domain of unknown function (DUF1850); Region: DUF1850; pfam08905
546271004785	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
546271004786	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
546271004787	substrate binding pocket [chemical binding]; other site
546271004788	membrane-bound complex binding site; other site
546271004789	hinge residues; other site
546271004790	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
546271004791	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
546271004792	putative ATP binding site [chemical binding]; other site
546271004793	putative substrate interface [chemical binding]; other site
546271004794	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
546271004795	nucleotide binding site [chemical binding]; other site
546271004796	SulA interaction site; other site
546271004797	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
546271004798	EamA-like transporter family; Region: EamA; pfam00892
546271004799	EamA-like transporter family; Region: EamA; pfam00892
546271004800	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
546271004801	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
546271004802	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
546271004803	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
546271004804	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
546271004805	dimerization interface [polypeptide binding]; other site
546271004806	ATP binding site [chemical binding]; other site
546271004807	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
546271004808	dimerization interface [polypeptide binding]; other site
546271004809	ATP binding site [chemical binding]; other site
546271004810	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
546271004811	putative active site [active]
546271004812	catalytic triad [active]
546271004813	Domain of unknown function (DUF386); Region: DUF386; cl01047
546271004814	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
546271004815	AsnC family; Region: AsnC_trans_reg; pfam01037
546271004816	hypothetical protein; Validated; Region: PRK07682
546271004817	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
546271004818	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546271004819	homodimer interface [polypeptide binding]; other site
546271004820	catalytic residue [active]
546271004821	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
546271004822	Domain of unknown function DUF20; Region: UPF0118; pfam01594
546271004823	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
546271004824	DALR anticodon binding domain; Region: DALR_1; pfam05746
546271004825	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
546271004826	dimer interface [polypeptide binding]; other site
546271004827	motif 1; other site
546271004828	active site
546271004829	motif 2; other site
546271004830	motif 3; other site
546271004831	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
546271004832	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
546271004833	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546271004834	Walker A/P-loop; other site
546271004835	ATP binding site [chemical binding]; other site
546271004836	Q-loop/lid; other site
546271004837	ABC transporter signature motif; other site
546271004838	Walker B; other site
546271004839	D-loop; other site
546271004840	H-loop/switch region; other site
546271004841	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
546271004842	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
546271004843	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546271004844	Walker A/P-loop; other site
546271004845	ATP binding site [chemical binding]; other site
546271004846	Q-loop/lid; other site
546271004847	ABC transporter signature motif; other site
546271004848	Walker B; other site
546271004849	D-loop; other site
546271004850	H-loop/switch region; other site
546271004851	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
546271004852	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
546271004853	dimer interface [polypeptide binding]; other site
546271004854	PYR/PP interface [polypeptide binding]; other site
546271004855	TPP binding site [chemical binding]; other site
546271004856	substrate binding site [chemical binding]; other site
546271004857	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
546271004858	Domain of unknown function; Region: EKR; pfam10371
546271004859	4Fe-4S binding domain; Region: Fer4_6; pfam12837
546271004860	4Fe-4S binding domain; Region: Fer4; pfam00037
546271004861	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
546271004862	TPP-binding site [chemical binding]; other site
546271004863	dimer interface [polypeptide binding]; other site
546271004864	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
546271004865	active site
546271004866	oxyanion hole [active]
546271004867	catalytic triad [active]
546271004868	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
546271004869	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
546271004870	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
546271004871	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
546271004872	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
546271004873	Cobalt chelatase (CbiK); Region: CbiK; pfam06180
546271004874	active site
546271004875	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
546271004876	active site
546271004877	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
546271004878	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
546271004879	active site
546271004880	substrate binding site [chemical binding]; other site
546271004881	metal binding site [ion binding]; metal-binding site
546271004882	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
546271004883	YbbR-like protein; Region: YbbR; pfam07949
546271004884	YbbR-like protein; Region: YbbR; pfam07949
546271004885	TIGR00159 family protein; Region: TIGR00159
546271004886	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
546271004887	Uncharacterized conserved protein [Function unknown]; Region: COG0062
546271004888	putative carbohydrate kinase; Provisional; Region: PRK10565
546271004889	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
546271004890	putative substrate binding site [chemical binding]; other site
546271004891	putative ATP binding site [chemical binding]; other site
546271004892	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
546271004893	flagellar motor protein MotB; Reviewed; Region: motB; PRK07734
546271004894	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
546271004895	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
546271004896	ligand binding site [chemical binding]; other site
546271004897	flagellar motor protein MotA; Validated; Region: PRK08124
546271004898	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
546271004899	Transcriptional regulator [Transcription]; Region: LysR; COG0583
546271004900	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
546271004901	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
546271004902	dimerization interface [polypeptide binding]; other site
546271004903	L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590
546271004904	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
546271004905	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546271004906	homodimer interface [polypeptide binding]; other site
546271004907	catalytic residue [active]
546271004908	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
546271004909	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546271004910	Walker A motif; other site
546271004911	ATP binding site [chemical binding]; other site
546271004912	Walker B motif; other site
546271004913	S-adenosylmethionine synthetase; Validated; Region: PRK05250
546271004914	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
546271004915	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
546271004916	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
546271004917	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
546271004918	Flavoprotein; Region: Flavoprotein; pfam02441
546271004919	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
546271004920	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
546271004921	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
546271004922	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
546271004923	catalytic site [active]
546271004924	G-X2-G-X-G-K; other site
546271004925	hypothetical protein; Provisional; Region: PRK04323
546271004926	hypothetical protein; Provisional; Region: PRK11820
546271004927	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
546271004928	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
546271004929	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
546271004930	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
546271004931	G1 box; other site
546271004932	putative GEF interaction site [polypeptide binding]; other site
546271004933	GTP/Mg2+ binding site [chemical binding]; other site
546271004934	Switch I region; other site
546271004935	G2 box; other site
546271004936	G3 box; other site
546271004937	Switch II region; other site
546271004938	G4 box; other site
546271004939	G5 box; other site
546271004940	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
546271004941	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640
546271004942	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
546271004943	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641
546271004944	L-aspartate oxidase; Provisional; Region: PRK06175
546271004945	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
546271004946	Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497
546271004947	putative Iron-sulfur protein interface [polypeptide binding]; other site
546271004948	proximal heme binding site [chemical binding]; other site
546271004949	distal heme binding site [chemical binding]; other site
546271004950	putative dimer interface [polypeptide binding]; other site
546271004951	Fumarase C-terminus; Region: Fumerase_C; cl00795
546271004952	fumarate hydratase; Provisional; Region: PRK06246
546271004953	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
546271004954	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
546271004955	active site
546271004956	metal binding site [ion binding]; metal-binding site
546271004957	homotetramer interface [polypeptide binding]; other site
546271004958	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
546271004959	active site
546271004960	dimerization interface [polypeptide binding]; other site
546271004961	ribonuclease PH; Reviewed; Region: rph; PRK00173
546271004962	Ribonuclease PH; Region: RNase_PH_bact; cd11362
546271004963	hexamer interface [polypeptide binding]; other site
546271004964	active site
546271004965	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996
546271004966	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
546271004967	active site
546271004968	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
546271004969	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
546271004970	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
546271004971	active site
546271004972	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
546271004973	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
546271004974	Substrate binding site; other site
546271004975	Mg++ binding site; other site
546271004976	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
546271004977	active site
546271004978	substrate binding site [chemical binding]; other site
546271004979	CoA binding site [chemical binding]; other site
546271004980	Transcriptional regulators [Transcription]; Region: GntR; COG1802
546271004981	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
546271004982	DNA-binding site [nucleotide binding]; DNA binding site
546271004983	FCD domain; Region: FCD; pfam07729
546271004984	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
546271004985	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
546271004986	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
546271004987	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
546271004988	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
546271004989	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
546271004990	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
546271004991	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
546271004992	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
546271004993	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
546271004994	Walker A/P-loop; other site
546271004995	ATP binding site [chemical binding]; other site
546271004996	Q-loop/lid; other site
546271004997	ABC transporter signature motif; other site
546271004998	Walker B; other site
546271004999	D-loop; other site
546271005000	H-loop/switch region; other site
546271005001	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546271005002	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
546271005003	Walker A/P-loop; other site
546271005004	ATP binding site [chemical binding]; other site
546271005005	Q-loop/lid; other site
546271005006	ABC transporter signature motif; other site
546271005007	Walker B; other site
546271005008	D-loop; other site
546271005009	H-loop/switch region; other site
546271005010	serine/threonine transporter SstT; Provisional; Region: PRK13628
546271005011	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
546271005012	S-layer homology domain; Region: SLH; pfam00395
546271005013	Escherichia coli YdjC-like family of  proteins; Region: YdjC; cd10808
546271005014	putative active site [active]
546271005015	YdjC motif; other site
546271005016	Mg binding site [ion binding]; other site
546271005017	putative homodimer interface [polypeptide binding]; other site
546271005018	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
546271005019	nucleoside/Zn binding site; other site
546271005020	dimer interface [polypeptide binding]; other site
546271005021	catalytic motif [active]
546271005022	Nuclease-related domain; Region: NERD; pfam08378
546271005023	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
546271005024	malate dehydrogenase; Reviewed; Region: PRK06223
546271005025	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
546271005026	dimer interface [polypeptide binding]; other site
546271005027	NAD(P) binding site [chemical binding]; other site
546271005028	tetramer (dimer of dimers) interface [polypeptide binding]; other site
546271005029	substrate binding site [chemical binding]; other site
546271005030	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
546271005031	Rubredoxin; Region: Rubredoxin; pfam00301
546271005032	iron binding site [ion binding]; other site
546271005033	Heme NO binding; Region: HNOB; pfam07700
546271005034	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
546271005035	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
546271005036	dimer interface [polypeptide binding]; other site
546271005037	putative CheW interface [polypeptide binding]; other site
546271005038	GtrA-like protein; Region: GtrA; pfam04138
546271005039	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
546271005040	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
546271005041	hypothetical protein; Provisional; Region: PRK13665
546271005042	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
546271005043	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
546271005044	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
546271005045	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
546271005046	active site
546271005047	metal binding site [ion binding]; metal-binding site
546271005048	PilZ domain; Region: PilZ; pfam07238
546271005049	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
546271005050	active site
546271005051	metal binding site [ion binding]; metal-binding site
546271005052	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
546271005053	Cobalt chelatase (CbiK); Region: CbiK; pfam06180
546271005054	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
546271005055	active site
546271005056	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
546271005057	active site
546271005058	N-terminal domain interface [polypeptide binding]; other site
546271005059	Protein of unknown function (DUF342); Region: DUF342; pfam03961
546271005060	RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288
546271005061	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
546271005062	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
546271005063	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
546271005064	DNA binding residues [nucleotide binding]
546271005065	putative metal dependent hydrolase; Provisional; Region: PRK11598
546271005066	chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13488
546271005067	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
546271005068	CheC-like family; Region: CheC; pfam04509
546271005069	CheC-like family; Region: CheC; pfam04509
546271005070	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
546271005071	putative CheA interaction surface; other site
546271005072	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
546271005073	putative binding surface; other site
546271005074	active site
546271005075	P2 response regulator binding domain; Region: P2; pfam07194
546271005076	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
546271005077	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
546271005078	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546271005079	ATP binding site [chemical binding]; other site
546271005080	Mg2+ binding site [ion binding]; other site
546271005081	G-X-G motif; other site
546271005082	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
546271005083	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
546271005084	Flagellar protein YcgR; Region: YcgR_2; pfam12945
546271005085	PilZ domain; Region: PilZ; pfam07238
546271005086	cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969
546271005087	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
546271005088	P-loop; other site
546271005089	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
546271005090	flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499
546271005091	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546271005092	SRP54-type protein, GTPase domain; Region: SRP54; smart00962
546271005093	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
546271005094	Walker A/P-loop; other site
546271005095	ATP binding site [chemical binding]; other site
546271005096	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
546271005097	FHIPEP family; Region: FHIPEP; pfam00771
546271005098	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
546271005099	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
546271005100	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
546271005101	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
546271005102	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
546271005103	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
546271005104	Response regulator receiver domain; Region: Response_reg; pfam00072
546271005105	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546271005106	active site
546271005107	phosphorylation site [posttranslational modification]
546271005108	intermolecular recognition site; other site
546271005109	dimerization interface [polypeptide binding]; other site
546271005110	flagellar motor switch protein; Validated; Region: PRK08119
546271005111	CheC-like family; Region: CheC; pfam04509
546271005112	CheC-like family; Region: CheC; pfam04509
546271005113	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
546271005114	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
546271005115	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
546271005116	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
546271005117	Flagellar protein (FlbD); Region: FlbD; cl00683
546271005118	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
546271005119	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
546271005120	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
546271005121	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
546271005122	Protein of unknown function (DUF3766); Region: DUF3766; cl11797
546271005123	flagellar basal body rod modification protein; Provisional; Region: flgD; PRK11911
546271005124	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
546271005125	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
546271005126	Uncharacterized conserved protein [Function unknown]; Region: COG3334
546271005127	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
546271005128	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
546271005129	N-acetyl-D-glucosamine binding site [chemical binding]; other site
546271005130	catalytic residue [active]
546271005131	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720
546271005132	Flagellar FliJ protein; Region: FliJ; pfam02050
546271005133	flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497
546271005134	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
546271005135	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
546271005136	Walker A motif/ATP binding site; other site
546271005137	Walker B motif; other site
546271005138	type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499
546271005139	Flagellar assembly protein FliH; Region: FliH; pfam02108
546271005140	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
546271005141	FliG C-terminal domain; Region: FliG_C; pfam01706
546271005142	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
546271005143	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
546271005144	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
546271005145	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
546271005146	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
546271005147	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
546271005148	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
546271005149	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
546271005150	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
546271005151	transcriptional repressor CodY; Validated; Region: PRK04158
546271005152	CodY GAF-like domain; Region: CodY; pfam06018
546271005153	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
546271005154	NAD-dependent deacetylase; Provisional; Region: PRK00481
546271005155	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
546271005156	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546271005157	TPR repeat; Region: TPR_11; pfam13414
546271005158	binding surface
546271005159	TPR motif; other site
546271005160	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
546271005161	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
546271005162	Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712
546271005163	AMIN domain; Region: AMIN; pfam11741
546271005164	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
546271005165	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
546271005166	active site
546271005167	metal binding site [ion binding]; metal-binding site
546271005168	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
546271005169	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
546271005170	Walker A/P-loop; other site
546271005171	ATP binding site [chemical binding]; other site
546271005172	Q-loop/lid; other site
546271005173	ABC transporter signature motif; other site
546271005174	Walker B; other site
546271005175	D-loop; other site
546271005176	H-loop/switch region; other site
546271005177	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
546271005178	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546271005179	dimer interface [polypeptide binding]; other site
546271005180	conserved gate region; other site
546271005181	putative PBP binding loops; other site
546271005182	ABC-ATPase subunit interface; other site
546271005183	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
546271005184	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
546271005185	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
546271005186	HlyD family secretion protein; Region: HlyD_3; pfam13437
546271005187	putative heme utilization radical SAM enzyme HutW; Region: rSAM_HutW; TIGR04107
546271005188	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546271005189	FeS/SAM binding site; other site
546271005190	Flavodoxin domain; Region: Flavodoxin_3; pfam12641
546271005191	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
546271005192	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
546271005193	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
546271005194	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
546271005195	enterobactin receptor protein; Provisional; Region: PRK13483
546271005196	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
546271005197	N-terminal plug; other site
546271005198	ligand-binding site [chemical binding]; other site
546271005199	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
546271005200	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
546271005201	ribonuclease III; Reviewed; Region: rnc; PRK00102
546271005202	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
546271005203	dimerization interface [polypeptide binding]; other site
546271005204	active site
546271005205	metal binding site [ion binding]; metal-binding site
546271005206	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
546271005207	dsRNA binding site [nucleotide binding]; other site
546271005208	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
546271005209	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
546271005210	dimer interface [polypeptide binding]; other site
546271005211	active site
546271005212	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
546271005213	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
546271005214	FMN binding site [chemical binding]; other site
546271005215	substrate binding site [chemical binding]; other site
546271005216	putative catalytic residue [active]
546271005217	acyl carrier protein; Provisional; Region: acpP; PRK00982
546271005218	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
546271005219	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
546271005220	NAD(P) binding site [chemical binding]; other site
546271005221	homotetramer interface [polypeptide binding]; other site
546271005222	homodimer interface [polypeptide binding]; other site
546271005223	active site
546271005224	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
546271005225	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
546271005226	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
546271005227	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
546271005228	FMN binding site [chemical binding]; other site
546271005229	substrate binding site [chemical binding]; other site
546271005230	putative catalytic residue [active]
546271005231	putative phosphate acyltransferase; Provisional; Region: PRK05331
546271005232	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
546271005233	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
546271005234	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
546271005235	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
546271005236	Zn2+ binding site [ion binding]; other site
546271005237	Mg2+ binding site [ion binding]; other site
546271005238	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
546271005239	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
546271005240	HlyD family secretion protein; Region: HlyD_3; pfam13437
546271005241	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
546271005242	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546271005243	Walker A/P-loop; other site
546271005244	ATP binding site [chemical binding]; other site
546271005245	Q-loop/lid; other site
546271005246	ABC transporter signature motif; other site
546271005247	Walker B; other site
546271005248	D-loop; other site
546271005249	H-loop/switch region; other site
546271005250	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546271005251	Walker A/P-loop; other site
546271005252	ATP binding site [chemical binding]; other site
546271005253	Q-loop/lid; other site
546271005254	ABC transporter signature motif; other site
546271005255	Walker B; other site
546271005256	D-loop; other site
546271005257	H-loop/switch region; other site
546271005258	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
546271005259	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
546271005260	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
546271005261	ABC-2 type transporter; Region: ABC2_membrane; cl17235
546271005262	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
546271005263	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546271005264	Walker A motif; other site
546271005265	ATP binding site [chemical binding]; other site
546271005266	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
546271005267	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
546271005268	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
546271005269	active site
546271005270	HslU subunit interaction site [polypeptide binding]; other site
546271005271	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
546271005272	Glucose inhibited division protein A; Region: GIDA; pfam01134
546271005273	DNA topoisomerase I; Validated; Region: PRK05582
546271005274	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
546271005275	active site
546271005276	interdomain interaction site; other site
546271005277	putative metal-binding site [ion binding]; other site
546271005278	nucleotide binding site [chemical binding]; other site
546271005279	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
546271005280	domain I; other site
546271005281	DNA binding groove [nucleotide binding]
546271005282	phosphate binding site [ion binding]; other site
546271005283	domain II; other site
546271005284	domain III; other site
546271005285	nucleotide binding site [chemical binding]; other site
546271005286	catalytic site [active]
546271005287	domain IV; other site
546271005288	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
546271005289	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
546271005290	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
546271005291	DNA protecting protein DprA; Region: dprA; TIGR00732
546271005292	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
546271005293	active site
546271005294	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
546271005295	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
546271005296	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
546271005297	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
546271005298	glutamine binding [chemical binding]; other site
546271005299	catalytic triad [active]
546271005300	anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564
546271005301	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
546271005302	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
546271005303	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
546271005304	substrate binding site [chemical binding]; other site
546271005305	active site
546271005306	catalytic residues [active]
546271005307	heterodimer interface [polypeptide binding]; other site
546271005308	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
546271005309	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
546271005310	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546271005311	catalytic residue [active]
546271005312	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
546271005313	active site
546271005314	ribulose/triose binding site [chemical binding]; other site
546271005315	phosphate binding site [ion binding]; other site
546271005316	substrate (anthranilate) binding pocket [chemical binding]; other site
546271005317	product (indole) binding pocket [chemical binding]; other site
546271005318	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
546271005319	active site
546271005320	Predicted membrane protein [Function unknown]; Region: COG2510
546271005321	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
546271005322	endonuclease III; Region: ENDO3c; smart00478
546271005323	minor groove reading motif; other site
546271005324	helix-hairpin-helix signature motif; other site
546271005325	substrate binding pocket [chemical binding]; other site
546271005326	active site
546271005327	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
546271005328	HSP70 interaction site [polypeptide binding]; other site
546271005329	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
546271005330	substrate binding site [polypeptide binding]; other site
546271005331	DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684
546271005332	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
546271005333	Zn binding sites [ion binding]; other site
546271005334	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
546271005335	dimer interface [polypeptide binding]; other site
546271005336	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
546271005337	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
546271005338	nucleotide binding site [chemical binding]; other site
546271005339	NEF interaction site [polypeptide binding]; other site
546271005340	SBD interface [polypeptide binding]; other site
546271005341	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
546271005342	dimer interface [polypeptide binding]; other site
546271005343	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
546271005344	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
546271005345	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
546271005346	Putative motility protein; Region: YjfB_motility; pfam14070
546271005347	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
546271005348	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546271005349	FeS/SAM binding site; other site
546271005350	HemN C-terminal domain; Region: HemN_C; pfam06969
546271005351	GTP-binding protein LepA; Provisional; Region: PRK05433
546271005352	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
546271005353	G1 box; other site
546271005354	putative GEF interaction site [polypeptide binding]; other site
546271005355	GTP/Mg2+ binding site [chemical binding]; other site
546271005356	Switch I region; other site
546271005357	G2 box; other site
546271005358	G3 box; other site
546271005359	Switch II region; other site
546271005360	G4 box; other site
546271005361	G5 box; other site
546271005362	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
546271005363	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
546271005364	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
546271005365	histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856
546271005366	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
546271005367	active site
546271005368	dimer interface [polypeptide binding]; other site
546271005369	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
546271005370	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546271005371	active site
546271005372	motif I; other site
546271005373	motif II; other site
546271005374	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546271005375	putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055
546271005376	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546271005377	FeS/SAM binding site; other site
546271005378	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
546271005379	putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054
546271005380	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546271005381	FeS/SAM binding site; other site
546271005382	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
546271005383	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
546271005384	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
546271005385	Uncharacterized conserved protein [Function unknown]; Region: COG1284
546271005386	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
546271005387	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
546271005388	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
546271005389	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
546271005390	Walker A/P-loop; other site
546271005391	ATP binding site [chemical binding]; other site
546271005392	Q-loop/lid; other site
546271005393	ABC transporter signature motif; other site
546271005394	Walker B; other site
546271005395	D-loop; other site
546271005396	H-loop/switch region; other site
546271005397	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
546271005398	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
546271005399	ABC-ATPase subunit  interface; other site
546271005400	dimer interface [polypeptide binding]; other site
546271005401	putative PBP binding regions; other site
546271005402	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
546271005403	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
546271005404	intersubunit interface [polypeptide binding]; other site
546271005405	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
546271005406	active site
546271005407	threonine synthase; Validated; Region: PRK06450
546271005408	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
546271005409	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
546271005410	catalytic residue [active]
546271005411	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
546271005412	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
546271005413	ATP-grasp domain; Region: ATP-grasp_4; cl17255
546271005414	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
546271005415	RelB antitoxin; Region: RelB; cl01171
546271005416	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
546271005417	Predicted membrane protein [Function unknown]; Region: COG2510
546271005418	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
546271005419	AAA domain; Region: AAA_14; pfam13173
546271005420	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
546271005421	UV radiation resistance protein and autophagy-related subunit 14; Region: Atg14; pfam10186
546271005422	Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983
546271005423	TIGR02646 family protein; Region: TIGR02646
546271005424	Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950
546271005425	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546271005426	Walker A/P-loop; other site
546271005427	ATP binding site [chemical binding]; other site
546271005428	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546271005429	Walker B; other site
546271005430	D-loop; other site
546271005431	H-loop/switch region; other site
546271005432	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
546271005433	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
546271005434	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
546271005435	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
546271005436	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
546271005437	Predicted methyltransferases [General function prediction only]; Region: COG0313
546271005438	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
546271005439	putative SAM binding site [chemical binding]; other site
546271005440	putative homodimer interface [polypeptide binding]; other site
546271005441	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
546271005442	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
546271005443	DNA polymerase III subunit delta'; Validated; Region: PRK08485
546271005444	Protein of unknown function (DUF327); Region: DUF327; pfam03885
546271005445	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
546271005446	putative acyl-acceptor binding pocket; other site
546271005447	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
546271005448	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
546271005449	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
546271005450	trimer interface [polypeptide binding]; other site
546271005451	active site
546271005452	UDP-GlcNAc binding site [chemical binding]; other site
546271005453	lipid binding site [chemical binding]; lipid-binding site
546271005454	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
546271005455	periplasmic chaperone; Provisional; Region: PRK10780
546271005456	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
546271005457	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
546271005458	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
546271005459	Surface antigen; Region: Bac_surface_Ag; pfam01103
546271005460	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
546271005461	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
546271005462	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
546271005463	DNA binding residues [nucleotide binding]
546271005464	Family of unknown function (DUF490); Region: DUF490; pfam04357
546271005465	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
546271005466	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
546271005467	Family of unknown function (DUF490); Region: DUF490; pfam04357
546271005468	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
546271005469	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
546271005470	mce related protein; Region: MCE; pfam02470
546271005471	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
546271005472	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
546271005473	Walker A/P-loop; other site
546271005474	ATP binding site [chemical binding]; other site
546271005475	Q-loop/lid; other site
546271005476	ABC transporter signature motif; other site
546271005477	Walker B; other site
546271005478	D-loop; other site
546271005479	H-loop/switch region; other site
546271005480	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
546271005481	Permease; Region: Permease; pfam02405
546271005482	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
546271005483	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
546271005484	AMIN domain; Region: AMIN; pfam11741
546271005485	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
546271005486	cell division protein FtsZ; Validated; Region: PRK09330
546271005487	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
546271005488	nucleotide binding site [chemical binding]; other site
546271005489	SulA interaction site; other site
546271005490	Protein of unknown function (DUF1290); Region: DUF1290; pfam06947
546271005491	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
546271005492	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
546271005493	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
546271005494	Cell division protein FtsQ; Region: FtsQ; pfam03799
546271005495	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
546271005496	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
546271005497	ATP-grasp domain; Region: ATP-grasp_4; cl17255
546271005498	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
546271005499	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
546271005500	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
546271005501	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
546271005502	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
546271005503	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
546271005504	active site
546271005505	homodimer interface [polypeptide binding]; other site
546271005506	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106
546271005507	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
546271005508	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
546271005509	phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445
546271005510	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
546271005511	Mg++ binding site [ion binding]; other site
546271005512	putative catalytic motif [active]
546271005513	putative substrate binding site [chemical binding]; other site
546271005514	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
546271005515	putative bifunctional UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase/UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase; Provisional; Region: PRK11929
546271005516	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
546271005517	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
546271005518	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
546271005519	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
546271005520	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
546271005521	Cell division protein FtsL; Region: FtsL; cl11433
546271005522	MraW methylase family; Region: Methyltransf_5; pfam01795
546271005523	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
546271005524	cell division protein MraZ; Reviewed; Region: PRK00326
546271005525	MraZ protein; Region: MraZ; pfam02381
546271005526	MraZ protein; Region: MraZ; pfam02381
546271005527	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
546271005528	putative active site [active]
546271005529	putative metal binding site [ion binding]; other site
546271005530	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
546271005531	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
546271005532	Chromate transporter; Region: Chromate_transp; pfam02417
546271005533	Chromate transporter; Region: Chromate_transp; pfam02417
546271005534	Autotransporter beta-domain; Region: Autotransporter; pfam03797
546271005535	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
546271005536	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
546271005537	N-terminal plug; other site
546271005538	ligand-binding site [chemical binding]; other site
546271005539	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
546271005540	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
546271005541	Metal-binding active site; metal-binding site
546271005542	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
546271005543	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
546271005544	Soluble P-type ATPase [General function prediction only]; Region: COG4087
546271005545	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
546271005546	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
546271005547	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
546271005548	ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063
546271005549	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
546271005550	gamma subunit interface [polypeptide binding]; other site
546271005551	epsilon subunit interface [polypeptide binding]; other site
546271005552	LBP interface [polypeptide binding]; other site
546271005553	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
546271005554	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
546271005555	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
546271005556	alpha subunit interaction interface [polypeptide binding]; other site
546271005557	Walker A motif; other site
546271005558	ATP binding site [chemical binding]; other site
546271005559	Walker B motif; other site
546271005560	inhibitor binding site; inhibition site
546271005561	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
546271005562	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
546271005563	core domain interface [polypeptide binding]; other site
546271005564	delta subunit interface [polypeptide binding]; other site
546271005565	epsilon subunit interface [polypeptide binding]; other site
546271005566	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
546271005567	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
546271005568	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
546271005569	beta subunit interaction interface [polypeptide binding]; other site
546271005570	Walker A motif; other site
546271005571	ATP binding site [chemical binding]; other site
546271005572	Walker B motif; other site
546271005573	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
546271005574	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
546271005575	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
546271005576	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
546271005577	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
546271005578	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
546271005579	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
546271005580	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
546271005581	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
546271005582	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
546271005583	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
546271005584	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
546271005585	active site
546271005586	homodimer interface [polypeptide binding]; other site
546271005587	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
546271005588	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
546271005589	Mg++ binding site [ion binding]; other site
546271005590	putative catalytic motif [active]
546271005591	substrate binding site [chemical binding]; other site
546271005592	Transposase IS200 like; Region: Y1_Tnp; pfam01797
546271005593	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
546271005594	30S subunit binding site; other site
546271005595	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
546271005596	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
546271005597	DNA-binding site [nucleotide binding]; DNA binding site
546271005598	RNA-binding motif; other site
546271005599	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
546271005600	active site
546271005601	dimer interface [polypeptide binding]; other site
546271005602	metal binding site [ion binding]; metal-binding site
546271005603	shikimate kinase; Reviewed; Region: aroK; PRK00131
546271005604	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
546271005605	ADP binding site [chemical binding]; other site
546271005606	magnesium binding site [ion binding]; other site
546271005607	putative shikimate binding site; other site
546271005608	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
546271005609	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
546271005610	Tetramer interface [polypeptide binding]; other site
546271005611	active site
546271005612	FMN-binding site [chemical binding]; other site
546271005613	Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256
546271005614	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
546271005615	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
546271005616	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
546271005617	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
546271005618	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
546271005619	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
546271005620	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
546271005621	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
546271005622	Walker A motif; other site
546271005623	ATP binding site [chemical binding]; other site
546271005624	Walker B motif; other site
546271005625	Type II/IV secretion system protein; Region: T2SE; pfam00437
546271005626	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
546271005627	Walker A motif; other site
546271005628	ATP binding site [chemical binding]; other site
546271005629	Walker B motif; other site
546271005630	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
546271005631	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
546271005632	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
546271005633	shikimate binding site; other site
546271005634	NAD(P) binding site [chemical binding]; other site
546271005635	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
546271005636	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
546271005637	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
546271005638	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
546271005639	Repair protein; Region: Repair_PSII; pfam04536
546271005640	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
546271005641	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
546271005642	Melibiase; Region: Melibiase; pfam02065
546271005643	Transcriptional regulators [Transcription]; Region: PurR; COG1609
546271005644	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
546271005645	DNA binding site [nucleotide binding]
546271005646	domain linker motif; other site
546271005647	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
546271005648	ligand binding site [chemical binding]; other site
546271005649	dimerization interface [polypeptide binding]; other site
546271005650	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
546271005651	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
546271005652	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
546271005653	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
546271005654	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
546271005655	NAD binding site [chemical binding]; other site
546271005656	homodimer interface [polypeptide binding]; other site
546271005657	active site
546271005658	substrate binding site [chemical binding]; other site
546271005659	galactokinase; Provisional; Region: PRK05322
546271005660	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
546271005661	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
546271005662	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
546271005663	beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525
546271005664	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
546271005665	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
546271005666	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
546271005667	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
546271005668	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
546271005669	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546271005670	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
546271005671	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
546271005672	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
546271005673	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
546271005674	putative active site [active]
546271005675	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
546271005676	PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005
546271005677	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
546271005678	active site turn [active]
546271005679	phosphorylation site [posttranslational modification]
546271005680	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
546271005681	HPr interaction site; other site
546271005682	glycerol kinase (GK) interaction site [polypeptide binding]; other site
546271005683	active site
546271005684	phosphorylation site [posttranslational modification]
546271005685	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
546271005686	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
546271005687	Ca binding site [ion binding]; other site
546271005688	active site
546271005689	catalytic site [active]
546271005690	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
546271005691	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546271005692	active site
546271005693	motif I; other site
546271005694	motif II; other site
546271005695	hexokinase; Provisional; Region: PTZ00107
546271005696	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
546271005697	nucleotide binding site [chemical binding]; other site
546271005698	Hexokinase; Region: Hexokinase_2; pfam03727
546271005699	hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980
546271005700	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
546271005701	Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278
546271005702	Protein of unknown function (DUF3084); Region: DUF3084; pfam11283
546271005703	Predicted permeases [General function prediction only]; Region: COG0795
546271005704	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
546271005705	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
546271005706	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
546271005707	Walker A/P-loop; other site
546271005708	ATP binding site [chemical binding]; other site
546271005709	Q-loop/lid; other site
546271005710	ABC transporter signature motif; other site
546271005711	Walker B; other site
546271005712	D-loop; other site
546271005713	H-loop/switch region; other site
546271005714	OstA-like protein; Region: OstA; cl00844
546271005715	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
546271005716	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
546271005717	putative acyl-acceptor binding pocket; other site
546271005718	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
546271005719	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
546271005720	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
546271005721	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
546271005722	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
546271005723	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
546271005724	Ligand binding site; other site
546271005725	oligomer interface; other site
546271005726	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
546271005727	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
546271005728	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
546271005729	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
546271005730	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
546271005731	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
546271005732	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
546271005733	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
546271005734	Walker A/P-loop; other site
546271005735	ATP binding site [chemical binding]; other site
546271005736	Q-loop/lid; other site
546271005737	ABC transporter signature motif; other site
546271005738	Walker B; other site
546271005739	D-loop; other site
546271005740	H-loop/switch region; other site
546271005741	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
546271005742	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
546271005743	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
546271005744	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
546271005745	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
546271005746	active site
546271005747	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
546271005748	UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512
546271005749	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
546271005750	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
546271005751	catalytic motif [active]
546271005752	Zn binding site [ion binding]; other site
546271005753	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
546271005754	dimer interface [polypeptide binding]; other site
546271005755	putative CheW interface [polypeptide binding]; other site
546271005756	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
546271005757	Ligand Binding Site [chemical binding]; other site
546271005758	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
546271005759	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
546271005760	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
546271005761	active site
546271005762	metal binding site [ion binding]; metal-binding site
546271005763	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
546271005764	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
546271005765	non-specific DNA binding site [nucleotide binding]; other site
546271005766	salt bridge; other site
546271005767	sequence-specific DNA binding site [nucleotide binding]; other site
546271005768	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
546271005769	glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377
546271005770	hydroxyglutarate oxidase; Provisional; Region: PRK11728
546271005771	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
546271005772	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
546271005773	anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329
546271005774	sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168
546271005775	Cysteine-rich domain; Region: CCG; pfam02754
546271005776	Cysteine-rich domain; Region: CCG; pfam02754
546271005777	glycerol kinase; Provisional; Region: glpK; PRK00047
546271005778	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
546271005779	N- and C-terminal domain interface [polypeptide binding]; other site
546271005780	active site
546271005781	MgATP binding site [chemical binding]; other site
546271005782	catalytic site [active]
546271005783	metal binding site [ion binding]; metal-binding site
546271005784	glycerol binding site [chemical binding]; other site
546271005785	homotetramer interface [polypeptide binding]; other site
546271005786	homodimer interface [polypeptide binding]; other site
546271005787	FBP binding site [chemical binding]; other site
546271005788	protein IIAGlc interface [polypeptide binding]; other site
546271005789	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
546271005790	amphipathic channel; other site
546271005791	Asn-Pro-Ala signature motifs; other site
546271005792	glycerol kinase; Provisional; Region: glpK; PRK00047
546271005793	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
546271005794	N- and C-terminal domain interface [polypeptide binding]; other site
546271005795	active site
546271005796	MgATP binding site [chemical binding]; other site
546271005797	catalytic site [active]
546271005798	metal binding site [ion binding]; metal-binding site
546271005799	glycerol binding site [chemical binding]; other site
546271005800	homotetramer interface [polypeptide binding]; other site
546271005801	homodimer interface [polypeptide binding]; other site
546271005802	FBP binding site [chemical binding]; other site
546271005803	protein IIAGlc interface [polypeptide binding]; other site
546271005804	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
546271005805	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
546271005806	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
546271005807	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
546271005808	transmembrane helices; other site
546271005809	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
546271005810	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
546271005811	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
546271005812	catalytic residue [active]
546271005813	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
546271005814	L-lactate permease; Region: Lactate_perm; cl00701
546271005815	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
546271005816	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
546271005817	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
546271005818	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
546271005819	Cysteine-rich domain; Region: CCG; pfam02754
546271005820	Cysteine-rich domain; Region: CCG; pfam02754
546271005821	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
546271005822	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
546271005823	FAD binding domain; Region: FAD_binding_4; pfam01565
546271005824	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
546271005825	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
546271005826	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
546271005827	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
546271005828	Ligand binding site [chemical binding]; other site
546271005829	Electron transfer flavoprotein domain; Region: ETF; pfam01012
546271005830	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
546271005831	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
546271005832	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
546271005833	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
546271005834	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
546271005835	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
546271005836	dimerization domain swap beta strand [polypeptide binding]; other site
546271005837	regulatory protein interface [polypeptide binding]; other site
546271005838	active site
546271005839	regulatory phosphorylation site [posttranslational modification]; other site
546271005840	PRC-barrel domain containing protein [General function prediction only]; Region: COG3881
546271005841	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
546271005842	Predicted permeases [General function prediction only]; Region: COG0701
546271005843	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
546271005844	dimerization interface [polypeptide binding]; other site
546271005845	putative DNA binding site [nucleotide binding]; other site
546271005846	putative Zn2+ binding site [ion binding]; other site
546271005847	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
546271005848	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
546271005849	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
546271005850	methionine sulfoxide reductase B; Provisional; Region: PRK00222
546271005851	SelR domain; Region: SelR; pfam01641
546271005852	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
546271005853	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
546271005854	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
546271005855	TrkA-N domain; Region: TrkA_N; pfam02254
546271005856	TrkA-C domain; Region: TrkA_C; pfam02080
546271005857	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546271005858	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546271005859	metal binding site [ion binding]; metal-binding site
546271005860	active site
546271005861	I-site; other site
546271005862	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
546271005863	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
546271005864	trimerization site [polypeptide binding]; other site
546271005865	active site
546271005866	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
546271005867	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
546271005868	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
546271005869	catalytic residue [active]
546271005870	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
546271005871	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
546271005872	FeS assembly protein SufB; Region: sufB; TIGR01980
546271005873	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
546271005874	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546271005875	FeS assembly ATPase SufC; Region: sufC; TIGR01978
546271005876	Walker A/P-loop; other site
546271005877	ATP binding site [chemical binding]; other site
546271005878	Q-loop/lid; other site
546271005879	ABC transporter signature motif; other site
546271005880	Walker B; other site
546271005881	D-loop; other site
546271005882	H-loop/switch region; other site
546271005883	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
546271005884	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546271005885	active site
546271005886	phosphorylation site [posttranslational modification]
546271005887	intermolecular recognition site; other site
546271005888	dimerization interface [polypeptide binding]; other site
546271005889	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
546271005890	dimerization interface [polypeptide binding]; other site
546271005891	DNA binding residues [nucleotide binding]
546271005892	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
546271005893	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
546271005894	glucose-6-phosphate isomerase; Provisional; Region: PRK00973
546271005895	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
546271005896	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
546271005897	dimer interface [polypeptide binding]; other site
546271005898	active site
546271005899	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
546271005900	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
546271005901	active site
546271005902	tetramer interface; other site
546271005903	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
546271005904	phosphomannomutase CpsG; Provisional; Region: PRK15414
546271005905	active site
546271005906	substrate binding site [chemical binding]; other site
546271005907	metal binding site [ion binding]; metal-binding site
546271005908	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
546271005909	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
546271005910	Flagellar L-ring protein; Region: FlgH; pfam02107
546271005911	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
546271005912	SAF-like; Region: SAF_2; pfam13144
546271005913	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
546271005914	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
546271005915	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
546271005916	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
546271005917	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
546271005918	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
546271005919	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
546271005920	rod shape-determining protein Mbl; Provisional; Region: PRK13928
546271005921	MreB and similar proteins; Region: MreB_like; cd10225
546271005922	nucleotide binding site [chemical binding]; other site
546271005923	Mg binding site [ion binding]; other site
546271005924	putative protofilament interaction site [polypeptide binding]; other site
546271005925	RodZ interaction site [polypeptide binding]; other site
546271005926	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
546271005927	active site
546271005928	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
546271005929	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
546271005930	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721
546271005931	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
546271005932	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
546271005933	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757
546271005934	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
546271005935	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752
546271005936	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
546271005937	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
546271005938	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
546271005939	Protein of unknown function DUF45; Region: DUF45; pfam01863
546271005940	DNA gyrase subunit A; Validated; Region: PRK05560
546271005941	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
546271005942	CAP-like domain; other site
546271005943	active site
546271005944	primary dimer interface [polypeptide binding]; other site
546271005945	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
546271005946	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
546271005947	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
546271005948	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
546271005949	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
546271005950	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
546271005951	Helix-turn-helix domain; Region: HTH_38; pfam13936
546271005952	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
546271005953	Integrase core domain; Region: rve; pfam00665
546271005954	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
546271005955	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
546271005956	dimerization interface [polypeptide binding]; other site
546271005957	domain crossover interface; other site
546271005958	redox-dependent activation switch; other site
546271005959	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
546271005960	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
546271005961	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
546271005962	putative substrate binding site [chemical binding]; other site
546271005963	putative ATP binding site [chemical binding]; other site
546271005964	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
546271005965	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
546271005966	active site
546271005967	phosphorylation site [posttranslational modification]
546271005968	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
546271005969	active site
546271005970	P-loop; other site
546271005971	phosphorylation site [posttranslational modification]
546271005972	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
546271005973	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
546271005974	dimerization interface [polypeptide binding]; other site
546271005975	putative DNA binding site [nucleotide binding]; other site
546271005976	putative Zn2+ binding site [ion binding]; other site
546271005977	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
546271005978	active site
546271005979	homodimer interface [polypeptide binding]; other site
546271005980	homotetramer interface [polypeptide binding]; other site
546271005981	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
546271005982	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
546271005983	GTP-binding protein YchF; Reviewed; Region: PRK09601
546271005984	YchF GTPase; Region: YchF; cd01900
546271005985	G1 box; other site
546271005986	GTP/Mg2+ binding site [chemical binding]; other site
546271005987	Switch I region; other site
546271005988	G2 box; other site
546271005989	Switch II region; other site
546271005990	G3 box; other site
546271005991	G4 box; other site
546271005992	G5 box; other site
546271005993	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
546271005994	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546271005995	Major Facilitator Superfamily; Region: MFS_1; pfam07690
546271005996	putative substrate translocation pore; other site
546271005997	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546271005998	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
546271005999	CheB methylesterase; Region: CheB_methylest; pfam01339
546271006000	Predicted membrane protein [Function unknown]; Region: COG2323
546271006001	Protein of unknown function (DUF3290); Region: DUF3290; pfam11694
546271006002	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
546271006003	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
546271006004	ABC-ATPase subunit  interface; other site
546271006005	dimer interface [polypeptide binding]; other site
546271006006	putative PBP binding regions; other site
546271006007	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
546271006008	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
546271006009	ABC-2 type transporter; Region: ABC2_membrane; cl17235
546271006010	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
546271006011	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
546271006012	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546271006013	Walker A/P-loop; other site
546271006014	ATP binding site [chemical binding]; other site
546271006015	Q-loop/lid; other site
546271006016	ABC transporter signature motif; other site
546271006017	Walker B; other site
546271006018	D-loop; other site
546271006019	H-loop/switch region; other site
546271006020	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
546271006021	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
546271006022	ADP-ribose binding site [chemical binding]; other site
546271006023	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
546271006024	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
546271006025	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546271006026	Walker A/P-loop; other site
546271006027	ATP binding site [chemical binding]; other site
546271006028	Q-loop/lid; other site
546271006029	ABC transporter signature motif; other site
546271006030	Walker B; other site
546271006031	D-loop; other site
546271006032	H-loop/switch region; other site
546271006033	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546271006034	dimer interface [polypeptide binding]; other site
546271006035	conserved gate region; other site
546271006036	putative PBP binding loops; other site
546271006037	ABC-ATPase subunit interface; other site
546271006038	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
546271006039	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
546271006040	4Fe-4S binding domain; Region: Fer4; cl02805
546271006041	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
546271006042	Transcriptional regulators [Transcription]; Region: PurR; COG1609
546271006043	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
546271006044	DNA binding site [nucleotide binding]
546271006045	domain linker motif; other site
546271006046	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
546271006047	dimerization interface [polypeptide binding]; other site
546271006048	ligand binding site [chemical binding]; other site
546271006049	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
546271006050	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
546271006051	substrate binding [chemical binding]; other site
546271006052	active site
546271006053	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
546271006054	HPr interaction site; other site
546271006055	glycerol kinase (GK) interaction site [polypeptide binding]; other site
546271006056	active site
546271006057	phosphorylation site [posttranslational modification]
546271006058	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
546271006059	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
546271006060	active site turn [active]
546271006061	phosphorylation site [posttranslational modification]
546271006062	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
546271006063	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
546271006064	Prismane/CO dehydrogenase family; Region: Prismane; pfam03063
546271006065	ACS interaction site; other site
546271006066	CODH interaction site; other site
546271006067	metal cluster binding site [ion binding]; other site
546271006068	NMT1-like family; Region: NMT1_2; pfam13379
546271006069	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
546271006070	substrate binding pocket [chemical binding]; other site
546271006071	membrane-bound complex binding site; other site
546271006072	hinge residues; other site
546271006073	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
546271006074	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546271006075	dimer interface [polypeptide binding]; other site
546271006076	conserved gate region; other site
546271006077	putative PBP binding loops; other site
546271006078	ABC-ATPase subunit interface; other site
546271006079	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
546271006080	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
546271006081	Walker A/P-loop; other site
546271006082	ATP binding site [chemical binding]; other site
546271006083	Q-loop/lid; other site
546271006084	ABC transporter signature motif; other site
546271006085	Walker B; other site
546271006086	D-loop; other site
546271006087	H-loop/switch region; other site
546271006088	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
546271006089	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
546271006090	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
546271006091	ligand binding site [chemical binding]; other site
546271006092	NAD binding site [chemical binding]; other site
546271006093	dimerization interface [polypeptide binding]; other site
546271006094	catalytic site [active]
546271006095	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
546271006096	putative L-serine binding site [chemical binding]; other site
546271006097	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
546271006098	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
546271006099	catalytic residue [active]
546271006100	Protein of unknown function (DUF4127); Region: DUF4127; pfam13552
546271006101	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655
546271006102	Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986
546271006103	putative bifunctional 4-alpha-glucanotransferase/glycogen debranching enzyme; Provisional; Region: PRK14510
546271006104	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
546271006105	homodimer interface [polypeptide binding]; other site
546271006106	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
546271006107	active site
546271006108	homodimer interface [polypeptide binding]; other site
546271006109	catalytic site [active]
546271006110	4-alpha-glucanotransferase; Provisional; Region: PRK14508
546271006111	glycogen synthase; Provisional; Region: glgA; PRK00654
546271006112	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
546271006113	ADP-binding pocket [chemical binding]; other site
546271006114	homodimer interface [polypeptide binding]; other site
546271006115	glycogen branching enzyme; Provisional; Region: PRK12313
546271006116	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
546271006117	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
546271006118	active site
546271006119	catalytic site [active]
546271006120	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
546271006121	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
546271006122	homodimer interface [polypeptide binding]; other site
546271006123	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
546271006124	active site pocket [active]
546271006125	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
546271006126	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
546271006127	ligand binding site; other site
546271006128	oligomer interface; other site
546271006129	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
546271006130	dimer interface [polypeptide binding]; other site
546271006131	N-terminal domain interface [polypeptide binding]; other site
546271006132	sulfate 1 binding site; other site
546271006133	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
546271006134	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
546271006135	ligand binding site; other site
546271006136	oligomer interface; other site
546271006137	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
546271006138	dimer interface [polypeptide binding]; other site
546271006139	N-terminal domain interface [polypeptide binding]; other site
546271006140	sulfate 1 binding site; other site
546271006141	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
546271006142	amidase catalytic site [active]
546271006143	Zn binding residues [ion binding]; other site
546271006144	substrate binding site [chemical binding]; other site
546271006145	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
546271006146	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
546271006147	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
546271006148	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
546271006149	active site
546271006150	Methyltransferase domain; Region: Methyltransf_23; pfam13489
546271006151	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546271006152	S-adenosylmethionine binding site [chemical binding]; other site
546271006153	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
546271006154	Uncharacterized conserved protein [Function unknown]; Region: COG1739
546271006155	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
546271006156	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
546271006157	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
546271006158	active site
546271006159	catalytic triad [active]
546271006160	oxyanion hole [active]
546271006161	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
546271006162	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
546271006163	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
546271006164	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
546271006165	dimer interface [polypeptide binding]; other site
546271006166	active site
546271006167	metal binding site [ion binding]; metal-binding site
546271006168	glutathione binding site [chemical binding]; other site
546271006169	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
546271006170	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
546271006171	ATP binding site [chemical binding]; other site
546271006172	putative Mg++ binding site [ion binding]; other site
546271006173	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
546271006174	nucleotide binding region [chemical binding]; other site
546271006175	ATP-binding site [chemical binding]; other site
546271006176	Domain of unknown function DUF21; Region: DUF21; pfam01595
546271006177	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
546271006178	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
546271006179	Transporter associated domain; Region: CorC_HlyC; smart01091
546271006180	DNA topoisomerase III; Provisional; Region: PRK07726
546271006181	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
546271006182	active site
546271006183	putative interdomain interaction site [polypeptide binding]; other site
546271006184	putative metal-binding site [ion binding]; other site
546271006185	putative nucleotide binding site [chemical binding]; other site
546271006186	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
546271006187	domain I; other site
546271006188	DNA binding groove [nucleotide binding]
546271006189	phosphate binding site [ion binding]; other site
546271006190	domain II; other site
546271006191	domain III; other site
546271006192	nucleotide binding site [chemical binding]; other site
546271006193	catalytic site [active]
546271006194	domain IV; other site
546271006195	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
546271006196	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
546271006197	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
546271006198	active site
546271006199	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
546271006200	substrate binding site [chemical binding]; other site
546271006201	catalytic residues [active]
546271006202	dimer interface [polypeptide binding]; other site
546271006203	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
546271006204	trimer interface [polypeptide binding]; other site
546271006205	active site
546271006206	Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991
546271006207	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
546271006208	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
546271006209	DHH family; Region: DHH; pfam01368
546271006210	DHHA1 domain; Region: DHHA1; pfam02272
546271006211	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
546271006212	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
546271006213	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
546271006214	ATP-dependent protease, Lon family; Region: spore_lon_C; TIGR02903
546271006215	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546271006216	Walker A motif; other site
546271006217	ATP binding site [chemical binding]; other site
546271006218	Walker B motif; other site
546271006219	arginine finger; other site
546271006220	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
546271006221	replicative DNA helicase; Region: DnaB; TIGR00665
546271006222	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
546271006223	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
546271006224	Walker A motif; other site
546271006225	ATP binding site [chemical binding]; other site
546271006226	Walker B motif; other site
546271006227	DNA binding loops [nucleotide binding]
546271006228	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
546271006229	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
546271006230	substrate binding [chemical binding]; other site
546271006231	active site
546271006232	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
546271006233	putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143
546271006234	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
546271006235	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
546271006236	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
546271006237	catalytic residue [active]
546271006238	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
546271006239	peroxiredoxin; Region: AhpC; TIGR03137
546271006240	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
546271006241	dimer interface [polypeptide binding]; other site
546271006242	decamer (pentamer of dimers) interface [polypeptide binding]; other site
546271006243	catalytic triad [active]
546271006244	peroxidatic and resolving cysteines [active]
546271006245	histidinol-phosphatase; Provisional; Region: PRK05588
546271006246	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
546271006247	active site
546271006248	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
546271006249	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546271006250	S-adenosylmethionine binding site [chemical binding]; other site
546271006251	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
546271006252	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
546271006253	putative active site [active]
546271006254	putative metal binding site [ion binding]; other site
546271006255	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
546271006256	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
546271006257	thymidylate kinase; Provisional; Region: PRK13975; cl17243
546271006258	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
546271006259	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
546271006260	dimerization interface [polypeptide binding]; other site
546271006261	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546271006262	dimer interface [polypeptide binding]; other site
546271006263	phosphorylation site [posttranslational modification]
546271006264	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546271006265	ATP binding site [chemical binding]; other site
546271006266	Mg2+ binding site [ion binding]; other site
546271006267	G-X-G motif; other site
546271006268	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
546271006269	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546271006270	active site
546271006271	phosphorylation site [posttranslational modification]
546271006272	intermolecular recognition site; other site
546271006273	dimerization interface [polypeptide binding]; other site
546271006274	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
546271006275	DNA binding site [nucleotide binding]
546271006276	Transcriptional regulator [Transcription]; Region: LysR; COG0583
546271006277	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
546271006278	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
546271006279	dimerization interface [polypeptide binding]; other site
546271006280	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
546271006281	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
546271006282	Autotransporter beta-domain; Region: Autotransporter; smart00869
546271006283	polyphosphate kinase; Provisional; Region: PRK05443
546271006284	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
546271006285	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
546271006286	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
546271006287	putative domain interface [polypeptide binding]; other site
546271006288	putative active site [active]
546271006289	catalytic site [active]
546271006290	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
546271006291	putative domain interface [polypeptide binding]; other site
546271006292	putative active site [active]
546271006293	catalytic site [active]
546271006294	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
546271006295	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
546271006296	Isochorismatase family; Region: Isochorismatase; pfam00857
546271006297	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
546271006298	catalytic triad [active]
546271006299	conserved cis-peptide bond; other site
546271006300	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
546271006301	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
546271006302	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
546271006303	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
546271006304	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
546271006305	oligomeric interface; other site
546271006306	putative active site [active]
546271006307	homodimer interface [polypeptide binding]; other site
546271006308	YibE/F-like protein; Region: YibE_F; pfam07907
546271006309	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
546271006310	CoenzymeA binding site [chemical binding]; other site
546271006311	subunit interaction site [polypeptide binding]; other site
546271006312	PHB binding site; other site
546271006313	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
546271006314	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
546271006315	active site
546271006316	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
546271006317	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
546271006318	transmembrane helices; other site
546271006319	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
546271006320	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
546271006321	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546271006322	dimer interface [polypeptide binding]; other site
546271006323	conserved gate region; other site
546271006324	putative PBP binding loops; other site
546271006325	ABC-ATPase subunit interface; other site
546271006326	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
546271006327	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546271006328	dimer interface [polypeptide binding]; other site
546271006329	conserved gate region; other site
546271006330	putative PBP binding loops; other site
546271006331	ABC-ATPase subunit interface; other site
546271006332	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
546271006333	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
546271006334	Walker A/P-loop; other site
546271006335	ATP binding site [chemical binding]; other site
546271006336	Q-loop/lid; other site
546271006337	ABC transporter signature motif; other site
546271006338	Walker B; other site
546271006339	D-loop; other site
546271006340	H-loop/switch region; other site
546271006341	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
546271006342	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
546271006343	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
546271006344	Walker A/P-loop; other site
546271006345	ATP binding site [chemical binding]; other site
546271006346	Q-loop/lid; other site
546271006347	ABC transporter signature motif; other site
546271006348	Walker B; other site
546271006349	D-loop; other site
546271006350	H-loop/switch region; other site
546271006351	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
546271006352	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490
546271006353	S-layer homology domain; Region: SLH; pfam00395
546271006354	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
546271006355	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
546271006356	thiamine phosphate binding site [chemical binding]; other site
546271006357	active site
546271006358	pyrophosphate binding site [ion binding]; other site
546271006359	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
546271006360	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
546271006361	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
546271006362	dimer interface [polypeptide binding]; other site
546271006363	ssDNA binding site [nucleotide binding]; other site
546271006364	tetramer (dimer of dimers) interface [polypeptide binding]; other site
546271006365	Ribosomal protein S6; Region: Ribosomal_S6; pfam01250
546271006366	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
546271006367	phosphoglyceromutase; Provisional; Region: PRK05434
546271006368	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
546271006369	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
546271006370	triosephosphate isomerase; Provisional; Region: PRK14567
546271006371	substrate binding site [chemical binding]; other site
546271006372	dimer interface [polypeptide binding]; other site
546271006373	catalytic triad [active]
546271006374	Phosphoglycerate kinase; Region: PGK; pfam00162
546271006375	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
546271006376	substrate binding site [chemical binding]; other site
546271006377	hinge regions; other site
546271006378	ADP binding site [chemical binding]; other site
546271006379	catalytic site [active]
546271006380	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
546271006381	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
546271006382	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
546271006383	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
546271006384	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
546271006385	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
546271006386	active site
546271006387	putative PHP Thumb interface [polypeptide binding]; other site
546271006388	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
546271006389	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281
546271006390	WYL domain; Region: WYL; pfam13280
546271006391	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
546271006392	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
546271006393	dimerization interface [polypeptide binding]; other site
546271006394	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546271006395	dimer interface [polypeptide binding]; other site
546271006396	phosphorylation site [posttranslational modification]
546271006397	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546271006398	ATP binding site [chemical binding]; other site
546271006399	Mg2+ binding site [ion binding]; other site
546271006400	G-X-G motif; other site
546271006401	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
546271006402	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546271006403	active site
546271006404	phosphorylation site [posttranslational modification]
546271006405	intermolecular recognition site; other site
546271006406	dimerization interface [polypeptide binding]; other site
546271006407	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
546271006408	DNA binding site [nucleotide binding]
546271006409	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
546271006410	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
546271006411	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546271006412	dimer interface [polypeptide binding]; other site
546271006413	conserved gate region; other site
546271006414	ABC-ATPase subunit interface; other site
546271006415	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
546271006416	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
546271006417	Walker A/P-loop; other site
546271006418	ATP binding site [chemical binding]; other site
546271006419	Q-loop/lid; other site
546271006420	ABC transporter signature motif; other site
546271006421	Walker B; other site
546271006422	D-loop; other site
546271006423	H-loop/switch region; other site
546271006424	NIL domain; Region: NIL; pfam09383
546271006425	Helix-turn-helix domain; Region: HTH_38; pfam13936
546271006426	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
546271006427	Integrase core domain; Region: rve; pfam00665
546271006428	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
546271006429	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
546271006430	Cl- selectivity filter; other site
546271006431	Cl- binding residues [ion binding]; other site
546271006432	pore gating glutamate residue; other site
546271006433	dimer interface [polypeptide binding]; other site
546271006434	H+/Cl- coupling transport residue; other site
546271006435	TrkA-C domain; Region: TrkA_C; pfam02080
546271006436	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
546271006437	active site
546271006438	catalytic residues [active]
546271006439	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546271006440	Response regulator receiver domain; Region: Response_reg; pfam00072
546271006441	active site
546271006442	phosphorylation site [posttranslational modification]
546271006443	intermolecular recognition site; other site
546271006444	dimerization interface [polypeptide binding]; other site
546271006445	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546271006446	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546271006447	metal binding site [ion binding]; metal-binding site
546271006448	active site
546271006449	I-site; other site
546271006450	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
546271006451	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
546271006452	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
546271006453	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
546271006454	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
546271006455	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
546271006456	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
546271006457	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
546271006458	protein binding site [polypeptide binding]; other site
546271006459	Protein of unknown function (DUF1232); Region: DUF1232; pfam06803
546271006460	Transposase IS200 like; Region: Y1_Tnp; pfam01797
546271006461	HTH domain; Region: HTH_11; pfam08279
546271006462	WYL domain; Region: WYL; pfam13280
546271006463	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
546271006464	Dynamin family; Region: Dynamin_N; pfam00350
546271006465	G1 box; other site
546271006466	GTP/Mg2+ binding site [chemical binding]; other site
546271006467	G2 box; other site
546271006468	Switch I region; other site
546271006469	G3 box; other site
546271006470	Switch II region; other site
546271006471	G4 box; other site
546271006472	G5 box; other site
546271006473	50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926
546271006474	G1 box; other site
546271006475	GTP/Mg2+ binding site [chemical binding]; other site
546271006476	G2 box; other site
546271006477	Switch I region; other site
546271006478	G3 box; other site
546271006479	Switch II region; other site
546271006480	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
546271006481	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
546271006482	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
546271006483	AAA domain; Region: AAA_33; pfam13671
546271006484	von Willebrand factor (vWF) type A domain; Region: VWA; smart00327
546271006485	metal ion-dependent adhesion site (MIDAS); other site
546271006486	Peptidase family M48; Region: Peptidase_M48; cl12018
546271006487	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
546271006488	Carbon starvation protein CstA; Region: CstA; pfam02554
546271006489	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
546271006490	hypothetical protein; Provisional; Region: PRK10410
546271006491	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
546271006492	metal ion-dependent adhesion site (MIDAS); other site
546271006493	Protein phosphatase 2C; Region: PP2C_2; pfam13672
546271006494	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
546271006495	substrate binding site [chemical binding]; other site
546271006496	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
546271006497	activation loop (A-loop); other site
546271006498	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
546271006499	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546271006500	FeS/SAM binding site; other site
546271006501	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111
546271006502	ATP cone domain; Region: ATP-cone; pfam03477
546271006503	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
546271006504	Class III ribonucleotide reductase; Region: RNR_III; cd01675
546271006505	effector binding site; other site
546271006506	active site
546271006507	Zn binding site [ion binding]; other site
546271006508	glycine loop; other site
546271006509	Mechanosensitive ion channel; Region: MS_channel; pfam00924
546271006510	Uncharacterized family 3; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_3; cd10160
546271006511	putative homodimer interface [polypeptide binding]; other site
546271006512	putative homotetramer interface [polypeptide binding]; other site
546271006513	putative metal binding site [ion binding]; other site
546271006514	putative homodimer-homodimer interface [polypeptide binding]; other site
546271006515	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
546271006516	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
546271006517	NAD binding site [chemical binding]; other site
546271006518	ligand binding site [chemical binding]; other site
546271006519	catalytic site [active]
546271006520	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
546271006521	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
546271006522	Soluble P-type ATPase [General function prediction only]; Region: COG4087
546271006523	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
546271006524	metal-binding site [ion binding]
546271006525	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
546271006526	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
546271006527	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
546271006528	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
546271006529	N-terminal plug; other site
546271006530	ligand-binding site [chemical binding]; other site
546271006531	Domain of unknown function (DUF1858); Region: DUF1858; pfam08984
546271006532	Uncharacterized conserved protein [Function unknown]; Region: COG2461
546271006533	Family of unknown function (DUF438); Region: DUF438; pfam04282
546271006534	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
546271006535	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
546271006536	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
546271006537	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
546271006538	MgtC family; Region: MgtC; pfam02308
546271006539	Predicted membrane protein [Function unknown]; Region: COG2855
546271006540	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
546271006541	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
546271006542	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
546271006543	HflX GTPase family; Region: HflX; cd01878
546271006544	G1 box; other site
546271006545	GTP/Mg2+ binding site [chemical binding]; other site
546271006546	Switch I region; other site
546271006547	G2 box; other site
546271006548	G3 box; other site
546271006549	Switch II region; other site
546271006550	G4 box; other site
546271006551	G5 box; other site
546271006552	Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301
546271006553	GDP-Fucose binding site [chemical binding]; other site
546271006554	37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245
546271006555	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
546271006556	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
546271006557	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
546271006558	Protein of unknown function (DUF819); Region: DUF819; cl02317
546271006559	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
546271006560	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
546271006561	putative ligand binding site [chemical binding]; other site
546271006562	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
546271006563	dimer interface [polypeptide binding]; other site
546271006564	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
546271006565	putative CheW interface [polypeptide binding]; other site
546271006566	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
546271006567	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
546271006568	Protein of unknown function (DUF3793); Region: DUF3793; pfam12672
546271006569	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
546271006570	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
546271006571	TM1410 hypothetical-related protein; Region: DUF297; cl00997
546271006572	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
546271006573	Predicted membrane protein [Function unknown]; Region: COG4267
546271006574	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813
546271006575	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
546271006576	Uncharacterized protein conserved in bacteria (DUF2194); Region: DUF2194; pfam09960
546271006577	Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG4878; cd10924
546271006578	NodB motif; other site
546271006579	putative active site [active]
546271006580	putative catalytic site [active]
546271006581	putative Zn binding site [ion binding]; other site
546271006582	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
546271006583	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
546271006584	active site
546271006585	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
546271006586	GAF domain; Region: GAF_3; pfam13492
546271006587	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
546271006588	NlpC/P60 family; Region: NLPC_P60; pfam00877
546271006589	Transcriptional regulator [Transcription]; Region: LytR; COG1316
546271006590	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
546271006591	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
546271006592	active site pocket [active]
546271006593	putative dimer interface [polypeptide binding]; other site
546271006594	putative cataytic base [active]
546271006595	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cl11435
546271006596	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
546271006597	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
546271006598	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
546271006599	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
546271006600	RNA binding site [nucleotide binding]; other site
546271006601	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
546271006602	Ferredoxin [Energy production and conversion]; Region: COG1146
546271006603	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
546271006604	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
546271006605	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
546271006606	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
546271006607	putative active site [active]
546271006608	SWIM zinc finger; Region: SWIM; pfam04434
546271006609	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
546271006610	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
546271006611	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
546271006612	ATP binding site [chemical binding]; other site
546271006613	putative Mg++ binding site [ion binding]; other site
546271006614	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
546271006615	nucleotide binding region [chemical binding]; other site
546271006616	ATP-binding site [chemical binding]; other site
546271006617	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
546271006618	active site
546271006619	DNA polymerase IV; Validated; Region: PRK02406
546271006620	DNA binding site [nucleotide binding]
546271006621	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516
546271006622	aconitate hydratase; Validated; Region: PRK07229
546271006623	Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585
546271006624	substrate binding site [chemical binding]; other site
546271006625	ligand binding site [chemical binding]; other site
546271006626	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
546271006627	substrate binding site [chemical binding]; other site
546271006628	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
546271006629	Citrate synthase; Region: Citrate_synt; pfam00285
546271006630	oxalacetate binding site [chemical binding]; other site
546271006631	citrylCoA binding site [chemical binding]; other site
546271006632	coenzyme A binding site [chemical binding]; other site
546271006633	catalytic triad [active]
546271006634	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
546271006635	isocitrate dehydrogenase; Validated; Region: PRK06451
546271006636	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
546271006637	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
546271006638	domain interfaces; other site
546271006639	active site
546271006640	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
546271006641	Protein of unknown function (DUF1385); Region: DUF1385; pfam07136
546271006642	peptide chain release factor 1; Validated; Region: prfA; PRK00591
546271006643	This domain is found in peptide chain release factors; Region: PCRF; smart00937
546271006644	RF-1 domain; Region: RF-1; pfam00472
546271006645	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
546271006646	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546271006647	S-adenosylmethionine binding site [chemical binding]; other site
546271006648	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
546271006649	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
546271006650	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
546271006651	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
546271006652	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
546271006653	MarR family; Region: MarR_2; pfam12802
546271006654	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
546271006655	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
546271006656	active site
546271006657	catalytic motif [active]
546271006658	Zn binding site [ion binding]; other site
546271006659	pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644
546271006660	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
546271006661	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
546271006662	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
546271006663	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
546271006664	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
546271006665	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
546271006666	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
546271006667	catalytic residues [active]
546271006668	Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768
546271006669	Uncharacterized conserved protein [Function unknown]; Region: COG2006
546271006670	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
546271006671	TrkA-N domain; Region: TrkA_N; pfam02254
546271006672	TrkA-C domain; Region: TrkA_C; pfam02080
546271006673	TrkA-N domain; Region: TrkA_N; pfam02254
546271006674	TrkA-C domain; Region: TrkA_C; pfam02080
546271006675	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
546271006676	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
546271006677	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
546271006678	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546271006679	homodimer interface [polypeptide binding]; other site
546271006680	catalytic residue [active]
546271006681	AAA domain; Region: AAA_14; pfam13173
546271006682	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
546271006683	Replication protein A C terminal; Region: RPA_C; pfam08784
546271006684	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
546271006685	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
546271006686	homodimer interface [polypeptide binding]; other site
546271006687	substrate-cofactor binding pocket; other site
546271006688	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546271006689	catalytic residue [active]
546271006690	alanine racemase; Reviewed; Region: alr; PRK00053
546271006691	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
546271006692	active site
546271006693	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
546271006694	dimer interface [polypeptide binding]; other site
546271006695	substrate binding site [chemical binding]; other site
546271006696	catalytic residues [active]
546271006697	seryl-tRNA synthetase; Provisional; Region: PRK05431
546271006698	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
546271006699	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
546271006700	dimer interface [polypeptide binding]; other site
546271006701	active site
546271006702	motif 1; other site
546271006703	motif 2; other site
546271006704	motif 3; other site
546271006705	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
546271006706	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546271006707	active site
546271006708	phosphorylation site [posttranslational modification]
546271006709	intermolecular recognition site; other site
546271006710	dimerization interface [polypeptide binding]; other site
546271006711	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
546271006712	DNA binding residues [nucleotide binding]
546271006713	dimerization interface [polypeptide binding]; other site
546271006714	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
546271006715	Histidine kinase; Region: HisKA_3; pfam07730
546271006716	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546271006717	ATP binding site [chemical binding]; other site
546271006718	Mg2+ binding site [ion binding]; other site
546271006719	G-X-G motif; other site
546271006720	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
546271006721	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
546271006722	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
546271006723	Dynamin family; Region: Dynamin_N; pfam00350
546271006724	G1 box; other site
546271006725	GTP/Mg2+ binding site [chemical binding]; other site
546271006726	G2 box; other site
546271006727	Switch I region; other site
546271006728	G3 box; other site
546271006729	Switch II region; other site
546271006730	G4 box; other site
546271006731	G5 box; other site
546271006732	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
546271006733	Dynamin family; Region: Dynamin_N; pfam00350
546271006734	G1 box; other site
546271006735	GTP/Mg2+ binding site [chemical binding]; other site
546271006736	G2 box; other site
546271006737	Switch I region; other site
546271006738	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
546271006739	G3 box; other site
546271006740	Switch II region; other site
546271006741	GTP/Mg2+ binding site [chemical binding]; other site
546271006742	G4 box; other site
546271006743	G5 box; other site
546271006744	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
546271006745	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
546271006746	active site
546271006747	Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596
546271006748	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
546271006749	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
546271006750	Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005
546271006751	menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699
546271006752	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546271006753	FeS/SAM binding site; other site
546271006754	putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700
546271006755	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546271006756	FeS/SAM binding site; other site
546271006757	Protein of unknown function (DUF3791); Region: DUF3791; pfam12668
546271006758	Protein of unknown function (DUF3990); Region: DUF3990; pfam13151
546271006759	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
546271006760	active site residue [active]
546271006761	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
546271006762	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
546271006763	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
546271006764	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
546271006765	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
546271006766	active site turn [active]
546271006767	phosphorylation site [posttranslational modification]
546271006768	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
546271006769	HPr interaction site; other site
546271006770	glycerol kinase (GK) interaction site [polypeptide binding]; other site
546271006771	active site
546271006772	phosphorylation site [posttranslational modification]
546271006773	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546271006774	S-adenosylmethionine binding site [chemical binding]; other site
546271006775	Rubrerythrin [Energy production and conversion]; Region: COG1592
546271006776	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
546271006777	binuclear metal center [ion binding]; other site
546271006778	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
546271006779	iron binding site [ion binding]; other site
546271006780	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
546271006781	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
546271006782	putative dimer interface [polypeptide binding]; other site
546271006783	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
546271006784	dimer interface [polypeptide binding]; other site
546271006785	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
546271006786	metal binding site [ion binding]; metal-binding site
546271006787	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
546271006788	Pyruvate formate lyase 1; Region: PFL1; cd01678
546271006789	coenzyme A binding site [chemical binding]; other site
546271006790	active site
546271006791	catalytic residues [active]
546271006792	glycine loop; other site
546271006793	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
546271006794	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546271006795	FeS/SAM binding site; other site
546271006796	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
546271006797	metal ion-dependent adhesion site (MIDAS); other site
546271006798	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
546271006799	Cysteine-rich domain; Region: CCG; pfam02754
546271006800	Cysteine-rich domain; Region: CCG; pfam02754
546271006801	FAD binding domain; Region: FAD_binding_4; pfam01565
546271006802	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
546271006803	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
546271006804	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
546271006805	transmembrane helices; other site
546271006806	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
546271006807	putative active site [active]
546271006808	putative metal binding residues [ion binding]; other site
546271006809	signature motif; other site
546271006810	putative dimer interface [polypeptide binding]; other site
546271006811	putative phosphate binding site [ion binding]; other site
546271006812	adenylosuccinate lyase; Provisional; Region: PRK07380
546271006813	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
546271006814	tetramer interface [polypeptide binding]; other site
546271006815	active site
546271006816	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
546271006817	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
546271006818	GDP-binding site [chemical binding]; other site
546271006819	ACT binding site; other site
546271006820	IMP binding site; other site
546271006821	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
546271006822	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
546271006823	ABC-ATPase subunit  interface; other site
546271006824	dimer interface [polypeptide binding]; other site
546271006825	putative PBP binding regions; other site
546271006826	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
546271006827	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
546271006828	Walker A/P-loop; other site
546271006829	ATP binding site [chemical binding]; other site
546271006830	Q-loop/lid; other site
546271006831	ABC transporter signature motif; other site
546271006832	Walker B; other site
546271006833	D-loop; other site
546271006834	H-loop/switch region; other site
546271006835	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
546271006836	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
546271006837	Walker A/P-loop; other site
546271006838	ATP binding site [chemical binding]; other site
546271006839	Q-loop/lid; other site
546271006840	ABC transporter signature motif; other site
546271006841	Walker B; other site
546271006842	D-loop; other site
546271006843	H-loop/switch region; other site
546271006844	ABC-2 type transporter; Region: ABC2_membrane; cl17235
546271006845	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
546271006846	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
546271006847	intersubunit interface [polypeptide binding]; other site
546271006848	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
546271006849	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
546271006850	N-terminal plug; other site
546271006851	ligand-binding site [chemical binding]; other site
546271006852	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
546271006853	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
546271006854	N-terminal plug; other site
546271006855	ligand-binding site [chemical binding]; other site
546271006856	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
546271006857	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
546271006858	dimer interface [polypeptide binding]; other site
546271006859	active site
546271006860	metal binding site [ion binding]; metal-binding site
546271006861	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
546271006862	HTH-like domain; Region: HTH_21; pfam13276
546271006863	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
546271006864	Integrase core domain; Region: rve; pfam00665
546271006865	Integrase core domain; Region: rve_2; pfam13333
546271006866	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
546271006867	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546271006868	Walker A motif; other site
546271006869	ATP binding site [chemical binding]; other site
546271006870	Walker B motif; other site
546271006871	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
546271006872	HipA-like C-terminal domain; Region: HipA_C; pfam07804
546271006873	HipA-like C-terminal domain; Region: HipA_C; pfam07804
546271006874	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
546271006875	substrate binding site [chemical binding]; other site
546271006876	THF binding site; other site
546271006877	zinc-binding site [ion binding]; other site
546271006878	amino acid transporter; Region: 2A0306; TIGR00909
546271006879	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
546271006880	FIST N domain; Region: FIST; pfam08495
546271006881	FIST C domain; Region: FIST_C; pfam10442
546271006882	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546271006883	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546271006884	metal binding site [ion binding]; metal-binding site
546271006885	active site
546271006886	I-site; other site
546271006887	ferric uptake regulator; Provisional; Region: fur; PRK09462
546271006888	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
546271006889	metal binding site 2 [ion binding]; metal-binding site
546271006890	putative DNA binding helix; other site
546271006891	metal binding site 1 [ion binding]; metal-binding site
546271006892	dimer interface [polypeptide binding]; other site
546271006893	structural Zn2+ binding site [ion binding]; other site
546271006894	SnoaL-like domain; Region: SnoaL_3; pfam13474
546271006895	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
546271006896	PAS domain; Region: PAS_9; pfam13426
546271006897	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546271006898	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546271006899	metal binding site [ion binding]; metal-binding site
546271006900	active site
546271006901	I-site; other site
546271006902	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
546271006903	Ligand Binding Site [chemical binding]; other site
546271006904	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
546271006905	Ligand Binding Site [chemical binding]; other site
546271006906	threonine dehydratase; Provisional; Region: PRK08198
546271006907	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
546271006908	tetramer interface [polypeptide binding]; other site
546271006909	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546271006910	catalytic residue [active]
546271006911	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
546271006912	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
546271006913	Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cl00018
546271006914	non-heme iron binding site [ion binding]; other site
546271006915	Desulfoferrodoxin [Energy production and conversion]; Region: COG2033
546271006916	dimer interface [polypeptide binding]; other site
546271006917	Desulfoferrodoxin; Region: Desulfoferrodox; pfam01880
546271006918	non-heme iron binding site [ion binding]; other site
546271006919	Cupin domain; Region: Cupin_2; pfam07883
546271006920	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
546271006921	Peptidase family M23; Region: Peptidase_M23; pfam01551
546271006922	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
546271006923	ParB-like nuclease domain; Region: ParBc; pfam02195
546271006924	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
546271006925	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
546271006926	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
546271006927	P-loop; other site
546271006928	Magnesium ion binding site [ion binding]; other site
546271006929	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
546271006930	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
546271006931	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
546271006932	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
546271006933	substrate binding pocket [chemical binding]; other site
546271006934	dihydropteroate synthase; Region: DHPS; TIGR01496
546271006935	dimer interface [polypeptide binding]; other site
546271006936	inhibitor binding site; inhibition site
546271006937	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
546271006938	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
546271006939	B12 binding site [chemical binding]; other site
546271006940	cobalt ligand [ion binding]; other site
546271006941	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
546271006942	6-phosphofructokinase; Provisional; Region: PRK03202
546271006943	active site
546271006944	ADP/pyrophosphate binding site [chemical binding]; other site
546271006945	dimerization interface [polypeptide binding]; other site
546271006946	allosteric effector site; other site
546271006947	fructose-1,6-bisphosphate binding site; other site
546271006948	5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106
546271006949	AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism]; Region: PurH; COG0138
546271006950	MAEBL; Provisional; Region: PTZ00121
546271006951	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
546271006952	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
546271006953	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
546271006954	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
546271006955	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
546271006956	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
546271006957	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
546271006958	trmE is a tRNA modification GTPase; Region: trmE; cd04164
546271006959	G1 box; other site
546271006960	GTP/Mg2+ binding site [chemical binding]; other site
546271006961	Switch I region; other site
546271006962	G2 box; other site
546271006963	Switch II region; other site
546271006964	G3 box; other site
546271006965	G4 box; other site
546271006966	G5 box; other site
546271006967	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
546271006968	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
546271006969	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
546271006970	G-X-X-G motif; other site
546271006971	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
546271006972	RxxxH motif; other site
546271006973	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
546271006974	Haemolytic domain; Region: Haemolytic; pfam01809
546271006975	ribonuclease P; Reviewed; Region: rnpA; PRK00499
546271006976	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399