-- dump date 20140620_062214 -- class Genbank::misc_feature -- table misc_feature_note -- id note 768490000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 768490000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 768490000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768490000004 Walker A motif; other site 768490000005 ATP binding site [chemical binding]; other site 768490000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 768490000007 Walker B motif; other site 768490000008 arginine finger; other site 768490000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 768490000010 DnaA box-binding interface [nucleotide binding]; other site 768490000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 768490000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 768490000013 putative DNA binding surface [nucleotide binding]; other site 768490000014 dimer interface [polypeptide binding]; other site 768490000015 beta-clamp/clamp loader binding surface; other site 768490000016 beta-clamp/translesion DNA polymerase binding surface; other site 768490000017 recF protein; Region: recf; TIGR00611 768490000018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768490000019 Walker A/P-loop; other site 768490000020 ATP binding site [chemical binding]; other site 768490000021 Q-loop/lid; other site 768490000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768490000023 ABC transporter signature motif; other site 768490000024 Walker B; other site 768490000025 D-loop; other site 768490000026 H-loop/switch region; other site 768490000027 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 768490000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490000029 Mg2+ binding site [ion binding]; other site 768490000030 G-X-G motif; other site 768490000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 768490000032 anchoring element; other site 768490000033 dimer interface [polypeptide binding]; other site 768490000034 ATP binding site [chemical binding]; other site 768490000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 768490000036 active site 768490000037 putative metal-binding site [ion binding]; other site 768490000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 768490000039 sugar phosphate phosphatase; Provisional; Region: PRK10513 768490000040 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768490000041 active site 768490000042 motif I; other site 768490000043 motif II; other site 768490000044 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768490000045 motif I; other site 768490000046 active site 768490000047 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 768490000048 ornithine cyclodeaminase; Validated; Region: PRK06823 768490000049 hypothetical protein; Provisional; Region: PRK06815 768490000050 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 768490000051 tetramer interface [polypeptide binding]; other site 768490000052 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490000053 catalytic residue [active] 768490000054 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 768490000055 hypothetical protein; Provisional; Region: PRK11616 768490000056 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 768490000057 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 768490000058 putative dimer interface [polypeptide binding]; other site 768490000059 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 768490000060 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 768490000061 putative dimer interface [polypeptide binding]; other site 768490000062 putative transporter; Validated; Region: PRK03818 768490000063 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 768490000064 TrkA-C domain; Region: TrkA_C; pfam02080 768490000065 TrkA-C domain; Region: TrkA_C; pfam02080 768490000066 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 768490000067 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 768490000068 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768490000069 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490000070 homodimer interface [polypeptide binding]; other site 768490000071 catalytic residue [active] 768490000072 alpha-amylase; Reviewed; Region: malS; PRK09505 768490000073 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 768490000074 active site 768490000075 catalytic site [active] 768490000076 Predicted transcriptional regulator [Transcription]; Region: COG3905 768490000077 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 768490000078 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 768490000079 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 768490000080 dimerization interface [polypeptide binding]; other site 768490000081 ligand binding site [chemical binding]; other site 768490000082 NADP binding site [chemical binding]; other site 768490000083 catalytic site [active] 768490000084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490000085 D-galactonate transporter; Region: 2A0114; TIGR00893 768490000086 putative substrate translocation pore; other site 768490000087 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768490000088 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 768490000089 substrate binding site [chemical binding]; other site 768490000090 ATP binding site [chemical binding]; other site 768490000091 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 768490000092 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768490000093 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768490000094 DNA binding site [nucleotide binding] 768490000095 domain linker motif; other site 768490000096 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 768490000097 putative dimerization interface [polypeptide binding]; other site 768490000098 putative ligand binding site [chemical binding]; other site 768490000099 putative outer membrane lipoprotein; Provisional; Region: PRK10510 768490000100 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 768490000101 ligand binding site [chemical binding]; other site 768490000102 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768490000103 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490000104 Coenzyme A binding pocket [chemical binding]; other site 768490000105 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 768490000106 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 768490000107 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 768490000108 active site 768490000109 catalytic triad [active] 768490000110 oxyanion hole [active] 768490000111 Autotransporter beta-domain; Region: Autotransporter; cl17461 768490000112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490000113 D-galactonate transporter; Region: 2A0114; TIGR00893 768490000114 putative substrate translocation pore; other site 768490000115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490000116 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 768490000117 dimer interface [polypeptide binding]; other site 768490000118 motif 1; other site 768490000119 active site 768490000120 motif 2; other site 768490000121 motif 3; other site 768490000122 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 768490000123 DALR anticodon binding domain; Region: DALR_1; pfam05746 768490000124 Fic family protein [Function unknown]; Region: COG3177 768490000125 Fic/DOC family; Region: Fic; pfam02661 768490000126 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 768490000127 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 768490000128 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 768490000129 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 768490000130 active site 768490000131 P-loop; other site 768490000132 phosphorylation site [posttranslational modification] 768490000133 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 768490000134 active site 768490000135 phosphorylation site [posttranslational modification] 768490000136 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 768490000137 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 768490000138 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 768490000139 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 768490000140 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 768490000141 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 768490000142 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768490000143 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768490000144 DNA-binding site [nucleotide binding]; DNA binding site 768490000145 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768490000146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490000147 homodimer interface [polypeptide binding]; other site 768490000148 catalytic residue [active] 768490000149 hypothetical protein; Provisional; Region: PRK11020 768490000150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490000151 S-adenosylmethionine binding site [chemical binding]; other site 768490000152 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 768490000153 MOSC domain; Region: MOSC; pfam03473 768490000154 3-alpha domain; Region: 3-alpha; pfam03475 768490000155 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768490000156 dimerization interface [polypeptide binding]; other site 768490000157 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 768490000158 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768490000159 dimer interface [polypeptide binding]; other site 768490000160 putative CheW interface [polypeptide binding]; other site 768490000161 superoxide dismutase; Provisional; Region: PRK10925 768490000162 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 768490000163 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 768490000164 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 768490000165 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 768490000166 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 768490000167 [4Fe-4S] binding site [ion binding]; other site 768490000168 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 768490000169 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 768490000170 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 768490000171 molybdopterin cofactor binding site; other site 768490000172 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 768490000173 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 768490000174 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 768490000175 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 768490000176 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 768490000177 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 768490000178 hypothetical protein; Provisional; Region: PRK11615 768490000179 putative glutathione S-transferase; Provisional; Region: PRK10357 768490000180 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 768490000181 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 768490000182 dimer interface [polypeptide binding]; other site 768490000183 N-terminal domain interface [polypeptide binding]; other site 768490000184 putative substrate binding pocket (H-site) [chemical binding]; other site 768490000185 selenocysteine synthase; Provisional; Region: PRK04311 768490000186 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 768490000187 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 768490000188 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768490000189 catalytic residue [active] 768490000190 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 768490000191 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 768490000192 G1 box; other site 768490000193 putative GEF interaction site [polypeptide binding]; other site 768490000194 GTP/Mg2+ binding site [chemical binding]; other site 768490000195 Switch I region; other site 768490000196 G2 box; other site 768490000197 G3 box; other site 768490000198 Switch II region; other site 768490000199 G4 box; other site 768490000200 G5 box; other site 768490000201 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 768490000202 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 768490000203 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 768490000204 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 768490000205 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 768490000206 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 768490000207 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 768490000208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490000209 putative substrate translocation pore; other site 768490000210 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 768490000211 Acyltransferase family; Region: Acyl_transf_3; pfam01757 768490000212 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 768490000213 conserved cys residue [active] 768490000214 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490000215 Isochorismatase family; Region: Isochorismatase; pfam00857 768490000216 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 768490000217 catalytic triad [active] 768490000218 conserved cis-peptide bond; other site 768490000219 putative deaminase; Validated; Region: PRK06846 768490000220 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 768490000221 active site 768490000222 xylulokinase; Provisional; Region: PRK15027 768490000223 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 768490000224 N- and C-terminal domain interface [polypeptide binding]; other site 768490000225 active site 768490000226 MgATP binding site [chemical binding]; other site 768490000227 catalytic site [active] 768490000228 metal binding site [ion binding]; metal-binding site 768490000229 xylulose binding site [chemical binding]; other site 768490000230 homodimer interface [polypeptide binding]; other site 768490000231 xylose isomerase; Provisional; Region: PRK05474 768490000232 xylose isomerase; Region: xylose_isom_A; TIGR02630 768490000233 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 768490000234 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 768490000235 putative ligand binding site [chemical binding]; other site 768490000236 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 768490000237 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768490000238 Walker A/P-loop; other site 768490000239 ATP binding site [chemical binding]; other site 768490000240 Q-loop/lid; other site 768490000241 ABC transporter signature motif; other site 768490000242 Walker B; other site 768490000243 D-loop; other site 768490000244 H-loop/switch region; other site 768490000245 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768490000246 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 768490000247 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768490000248 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768490000249 TM-ABC transporter signature motif; other site 768490000250 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 768490000251 putative dimerization interface [polypeptide binding]; other site 768490000252 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768490000253 putative ligand binding site [chemical binding]; other site 768490000254 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490000255 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768490000256 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490000257 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490000258 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768490000259 dimerization interface [polypeptide binding]; other site 768490000260 putative cyanate transporter; Provisional; Region: cynX; PRK09705 768490000261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490000262 putative substrate translocation pore; other site 768490000263 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 768490000264 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 768490000265 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 768490000266 active site 768490000267 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 768490000268 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 768490000269 putative active site [active] 768490000270 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768490000271 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 768490000272 Walker A/P-loop; other site 768490000273 ATP binding site [chemical binding]; other site 768490000274 Q-loop/lid; other site 768490000275 ABC transporter signature motif; other site 768490000276 Walker B; other site 768490000277 D-loop; other site 768490000278 H-loop/switch region; other site 768490000279 HlyD family secretion protein; Region: HlyD; pfam00529 768490000280 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768490000281 HlyD family secretion protein; Region: HlyD_3; pfam13437 768490000282 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 768490000283 active site 768490000284 NTP binding site [chemical binding]; other site 768490000285 metal binding triad [ion binding]; metal-binding site 768490000286 Autoinducer binding domain; Region: Autoind_bind; pfam03472 768490000287 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768490000288 DNA binding residues [nucleotide binding] 768490000289 dimerization interface [polypeptide binding]; other site 768490000290 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 768490000291 catalytic core [active] 768490000292 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 768490000293 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768490000294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490000295 putative substrate translocation pore; other site 768490000296 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490000297 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490000298 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768490000299 putative effector binding pocket; other site 768490000300 dimerization interface [polypeptide binding]; other site 768490000301 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 768490000302 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768490000303 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768490000304 NAD(P) binding site [chemical binding]; other site 768490000305 active site 768490000306 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490000307 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490000308 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768490000309 dimerization interface [polypeptide binding]; other site 768490000310 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 768490000311 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768490000312 NAD(P) binding site [chemical binding]; other site 768490000313 active site 768490000314 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 768490000315 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768490000316 active site turn [active] 768490000317 phosphorylation site [posttranslational modification] 768490000318 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768490000319 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 768490000320 HPr interaction site; other site 768490000321 glycerol kinase (GK) interaction site [polypeptide binding]; other site 768490000322 active site 768490000323 phosphorylation site [posttranslational modification] 768490000324 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 768490000325 beta-galactosidase; Region: BGL; TIGR03356 768490000326 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 768490000327 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 768490000328 HD domain; Region: HD_4; pfam13328 768490000329 Transcriptional regulators [Transcription]; Region: MarR; COG1846 768490000330 MarR family; Region: MarR; pfam01047 768490000331 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 768490000332 phosphoethanolamine transferase; Provisional; Region: PRK11560 768490000333 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 768490000334 Sulfatase; Region: Sulfatase; pfam00884 768490000335 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 768490000336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490000337 active site 768490000338 phosphorylation site [posttranslational modification] 768490000339 intermolecular recognition site; other site 768490000340 dimerization interface [polypeptide binding]; other site 768490000341 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768490000342 DNA binding residues [nucleotide binding] 768490000343 dimerization interface [polypeptide binding]; other site 768490000344 sensory histidine kinase UhpB; Provisional; Region: PRK11644 768490000345 MASE1; Region: MASE1; cl17823 768490000346 MASE1; Region: MASE1; cl17823 768490000347 Histidine kinase; Region: HisKA_3; pfam07730 768490000348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490000349 ATP binding site [chemical binding]; other site 768490000350 Mg2+ binding site [ion binding]; other site 768490000351 G-X-G motif; other site 768490000352 regulatory protein UhpC; Provisional; Region: PRK11663 768490000353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490000354 putative substrate translocation pore; other site 768490000355 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490000356 Predicted transcriptional regulator [Transcription]; Region: COG4190 768490000357 N-terminal Early set domain associated with the catalytic domain of chitinase; Region: E_set_Chitinase_N; cd02848 768490000358 Glyco_18 domain; Region: Glyco_18; smart00636 768490000359 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 768490000360 active site 768490000361 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 768490000362 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 768490000363 peptide binding site [polypeptide binding]; other site 768490000364 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 768490000365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490000366 dimer interface [polypeptide binding]; other site 768490000367 conserved gate region; other site 768490000368 putative PBP binding loops; other site 768490000369 ABC-ATPase subunit interface; other site 768490000370 dipeptide transporter; Provisional; Region: PRK10913 768490000371 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 768490000372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490000373 dimer interface [polypeptide binding]; other site 768490000374 conserved gate region; other site 768490000375 putative PBP binding loops; other site 768490000376 ABC-ATPase subunit interface; other site 768490000377 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 768490000378 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768490000379 Walker A/P-loop; other site 768490000380 ATP binding site [chemical binding]; other site 768490000381 Q-loop/lid; other site 768490000382 ABC transporter signature motif; other site 768490000383 Walker B; other site 768490000384 D-loop; other site 768490000385 H-loop/switch region; other site 768490000386 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768490000387 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 768490000388 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768490000389 Walker A/P-loop; other site 768490000390 ATP binding site [chemical binding]; other site 768490000391 Q-loop/lid; other site 768490000392 ABC transporter signature motif; other site 768490000393 Walker B; other site 768490000394 D-loop; other site 768490000395 H-loop/switch region; other site 768490000396 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 768490000397 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 768490000398 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 768490000399 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 768490000400 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 768490000401 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 768490000402 YhjQ protein; Region: YhjQ; pfam06564 768490000403 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 768490000404 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 768490000405 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 768490000406 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 768490000407 DXD motif; other site 768490000408 PilZ domain; Region: PilZ; pfam07238 768490000409 cellulose synthase regulator protein; Provisional; Region: PRK11114 768490000410 endo-1,4-D-glucanase; Provisional; Region: PRK11097 768490000411 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 768490000412 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768490000413 TPR motif; other site 768490000414 binding surface 768490000415 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768490000416 binding surface 768490000417 TPR motif; other site 768490000418 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768490000419 binding surface 768490000420 TPR motif; other site 768490000421 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 768490000422 putative diguanylate cyclase; Provisional; Region: PRK13561 768490000423 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768490000424 metal binding site [ion binding]; metal-binding site 768490000425 active site 768490000426 I-site; other site 768490000427 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768490000428 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 768490000429 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 768490000430 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 768490000431 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 768490000432 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 768490000433 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 768490000434 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 768490000435 Part of AAA domain; Region: AAA_19; pfam13245 768490000436 Family description; Region: UvrD_C_2; pfam13538 768490000437 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 768490000438 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 768490000439 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 768490000440 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 768490000441 ATP binding site [chemical binding]; other site 768490000442 Mg++ binding site [ion binding]; other site 768490000443 motif III; other site 768490000444 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768490000445 nucleotide binding region [chemical binding]; other site 768490000446 ATP-binding site [chemical binding]; other site 768490000447 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 768490000448 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 768490000449 catalytic residues [active] 768490000450 transcription termination factor Rho; Provisional; Region: rho; PRK09376 768490000451 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 768490000452 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 768490000453 RNA binding site [nucleotide binding]; other site 768490000454 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 768490000455 multimer interface [polypeptide binding]; other site 768490000456 Walker A motif; other site 768490000457 ATP binding site [chemical binding]; other site 768490000458 Walker B motif; other site 768490000459 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 768490000460 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 768490000461 Mg++ binding site [ion binding]; other site 768490000462 putative catalytic motif [active] 768490000463 substrate binding site [chemical binding]; other site 768490000464 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 768490000465 Chain length determinant protein; Region: Wzz; cl15801 768490000466 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 768490000467 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 768490000468 active site 768490000469 homodimer interface [polypeptide binding]; other site 768490000470 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 768490000471 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 768490000472 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 768490000473 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 768490000474 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 768490000475 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 768490000476 NAD binding site [chemical binding]; other site 768490000477 substrate binding site [chemical binding]; other site 768490000478 homodimer interface [polypeptide binding]; other site 768490000479 active site 768490000480 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 768490000481 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 768490000482 substrate binding site; other site 768490000483 tetramer interface; other site 768490000484 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768490000485 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490000486 Coenzyme A binding pocket [chemical binding]; other site 768490000487 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 768490000488 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 768490000489 inhibitor-cofactor binding pocket; inhibition site 768490000490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490000491 catalytic residue [active] 768490000492 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 768490000493 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 768490000494 putative common antigen polymerase; Provisional; Region: PRK02975 768490000495 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 768490000496 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 768490000497 putative transport protein YifK; Provisional; Region: PRK10746 768490000498 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 768490000499 HemY protein N-terminus; Region: HemY_N; pfam07219 768490000500 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 768490000501 TPR motif; other site 768490000502 binding surface 768490000503 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 768490000504 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 768490000505 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 768490000506 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 768490000507 active site 768490000508 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 768490000509 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 768490000510 domain interfaces; other site 768490000511 active site 768490000512 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 768490000513 adenylate cyclase; Provisional; Region: cyaA; PRK09450 768490000514 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 768490000515 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 768490000516 putative iron binding site [ion binding]; other site 768490000517 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 768490000518 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 768490000519 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 768490000520 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 768490000521 hypothetical protein; Provisional; Region: PRK10963 768490000522 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 768490000523 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768490000524 active site 768490000525 DNA binding site [nucleotide binding] 768490000526 Int/Topo IB signature motif; other site 768490000527 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 768490000528 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768490000529 motif II; other site 768490000530 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 768490000531 Part of AAA domain; Region: AAA_19; pfam13245 768490000532 Family description; Region: UvrD_C_2; pfam13538 768490000533 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 768490000534 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 768490000535 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 768490000536 oligomer interface [polypeptide binding]; other site 768490000537 Cl binding site [ion binding]; other site 768490000538 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 768490000539 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 768490000540 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 768490000541 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 768490000542 EamA-like transporter family; Region: EamA; cl17759 768490000543 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 768490000544 CoenzymeA binding site [chemical binding]; other site 768490000545 subunit interaction site [polypeptide binding]; other site 768490000546 PHB binding site; other site 768490000547 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 768490000548 dimerization interface [polypeptide binding]; other site 768490000549 substrate binding site [chemical binding]; other site 768490000550 active site 768490000551 calcium binding site [ion binding]; other site 768490000552 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 768490000553 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768490000554 ATP binding site [chemical binding]; other site 768490000555 putative Mg++ binding site [ion binding]; other site 768490000556 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768490000557 nucleotide binding region [chemical binding]; other site 768490000558 ATP-binding site [chemical binding]; other site 768490000559 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 768490000560 HRDC domain; Region: HRDC; pfam00570 768490000561 threonine efflux system; Provisional; Region: PRK10229 768490000562 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 768490000563 lysophospholipase L2; Provisional; Region: PRK10749 768490000564 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 768490000565 putative hydrolase; Provisional; Region: PRK10976 768490000566 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768490000567 active site 768490000568 motif I; other site 768490000569 motif II; other site 768490000570 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768490000571 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 768490000572 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 768490000573 active site 768490000574 catalytic site [active] 768490000575 metal binding site [ion binding]; metal-binding site 768490000576 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 768490000577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490000578 putative substrate translocation pore; other site 768490000579 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 768490000580 hydroxyglutarate oxidase; Provisional; Region: PRK11728 768490000581 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 768490000582 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 768490000583 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 768490000584 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 768490000585 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768490000586 Cysteine-rich domain; Region: CCG; pfam02754 768490000587 Cysteine-rich domain; Region: CCG; pfam02754 768490000588 hypothetical protein; Provisional; Region: PRK11615 768490000589 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490000590 Coenzyme A binding pocket [chemical binding]; other site 768490000591 hypothetical protein; Provisional; Region: PRK11212 768490000592 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 768490000593 CPxP motif; other site 768490000594 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 768490000595 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 768490000596 metal-binding site [ion binding] 768490000597 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768490000598 Soluble P-type ATPase [General function prediction only]; Region: COG4087 768490000599 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 768490000600 active site 768490000601 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 768490000602 Protease inhibitor Inh; Region: Inh; pfam02974 768490000603 Predicted membrane protein [Function unknown]; Region: COG3714 768490000604 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 768490000605 hypothetical protein; Provisional; Region: PRK10910 768490000606 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 768490000607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490000608 S-adenosylmethionine binding site [chemical binding]; other site 768490000609 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 768490000610 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 768490000611 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 768490000612 P loop; other site 768490000613 GTP binding site [chemical binding]; other site 768490000614 cell division protein FtsE; Provisional; Region: PRK10908 768490000615 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768490000616 Walker A/P-loop; other site 768490000617 ATP binding site [chemical binding]; other site 768490000618 Q-loop/lid; other site 768490000619 ABC transporter signature motif; other site 768490000620 Walker B; other site 768490000621 D-loop; other site 768490000622 H-loop/switch region; other site 768490000623 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 768490000624 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 768490000625 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 768490000626 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768490000627 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768490000628 DNA binding residues [nucleotide binding] 768490000629 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 768490000630 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 768490000631 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 768490000632 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 768490000633 dimerization interface [polypeptide binding]; other site 768490000634 ligand binding site [chemical binding]; other site 768490000635 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768490000636 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 768490000637 TM-ABC transporter signature motif; other site 768490000638 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 768490000639 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 768490000640 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 768490000641 TM-ABC transporter signature motif; other site 768490000642 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 768490000643 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 768490000644 Walker A/P-loop; other site 768490000645 ATP binding site [chemical binding]; other site 768490000646 Q-loop/lid; other site 768490000647 ABC transporter signature motif; other site 768490000648 Walker B; other site 768490000649 D-loop; other site 768490000650 H-loop/switch region; other site 768490000651 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 768490000652 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 768490000653 Walker A/P-loop; other site 768490000654 ATP binding site [chemical binding]; other site 768490000655 Q-loop/lid; other site 768490000656 ABC transporter signature motif; other site 768490000657 Walker B; other site 768490000658 D-loop; other site 768490000659 H-loop/switch region; other site 768490000660 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 768490000661 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768490000662 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490000663 homodimer interface [polypeptide binding]; other site 768490000664 catalytic residue [active] 768490000665 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 768490000666 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 768490000667 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 768490000668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490000669 dimer interface [polypeptide binding]; other site 768490000670 conserved gate region; other site 768490000671 putative PBP binding loops; other site 768490000672 ABC-ATPase subunit interface; other site 768490000673 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 768490000674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490000675 dimer interface [polypeptide binding]; other site 768490000676 conserved gate region; other site 768490000677 putative PBP binding loops; other site 768490000678 ABC-ATPase subunit interface; other site 768490000679 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 768490000680 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 768490000681 Walker A/P-loop; other site 768490000682 ATP binding site [chemical binding]; other site 768490000683 Q-loop/lid; other site 768490000684 ABC transporter signature motif; other site 768490000685 Walker B; other site 768490000686 D-loop; other site 768490000687 H-loop/switch region; other site 768490000688 TOBE domain; Region: TOBE_2; pfam08402 768490000689 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 768490000690 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 768490000691 putative active site [active] 768490000692 catalytic site [active] 768490000693 putative metal binding site [ion binding]; other site 768490000694 Predicted permeases [General function prediction only]; Region: COG0679 768490000695 EamA-like transporter family; Region: EamA; pfam00892 768490000696 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 768490000697 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 768490000698 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490000699 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 768490000700 putative dimerization interface [polypeptide binding]; other site 768490000701 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 768490000702 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 768490000703 THF binding site; other site 768490000704 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 768490000705 substrate binding site [chemical binding]; other site 768490000706 THF binding site; other site 768490000707 zinc-binding site [ion binding]; other site 768490000708 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 768490000709 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 768490000710 uridine phosphorylase; Provisional; Region: PRK11178 768490000711 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 768490000712 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 768490000713 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 768490000714 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 768490000715 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 768490000716 DNA recombination protein RmuC; Provisional; Region: PRK10361 768490000717 RmuC family; Region: RmuC; pfam02646 768490000718 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 768490000719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490000720 S-adenosylmethionine binding site [chemical binding]; other site 768490000721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 768490000722 SCP-2 sterol transfer family; Region: SCP2; pfam02036 768490000723 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 768490000724 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 768490000725 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 768490000726 sec-independent translocase; Provisional; Region: PRK01770 768490000727 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 768490000728 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 768490000729 active site 768490000730 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 768490000731 dimer interface [polypeptide binding]; other site 768490000732 active site 768490000733 aspartate-rich active site metal binding site; other site 768490000734 allosteric magnesium binding site [ion binding]; other site 768490000735 Schiff base residues; other site 768490000736 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 768490000737 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 768490000738 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 768490000739 active site pocket [active] 768490000740 oxyanion hole [active] 768490000741 catalytic triad [active] 768490000742 active site nucleophile [active] 768490000743 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 768490000744 FMN reductase; Validated; Region: fre; PRK08051 768490000745 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 768490000746 FAD binding pocket [chemical binding]; other site 768490000747 FAD binding motif [chemical binding]; other site 768490000748 phosphate binding motif [ion binding]; other site 768490000749 beta-alpha-beta structure motif; other site 768490000750 NAD binding pocket [chemical binding]; other site 768490000751 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 768490000752 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 768490000753 dimer interface [polypeptide binding]; other site 768490000754 active site 768490000755 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 768490000756 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768490000757 substrate binding site [chemical binding]; other site 768490000758 oxyanion hole (OAH) forming residues; other site 768490000759 trimer interface [polypeptide binding]; other site 768490000760 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 768490000761 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768490000762 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768490000763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490000764 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768490000765 putative substrate translocation pore; other site 768490000766 proline dipeptidase; Provisional; Region: PRK13607 768490000767 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 768490000768 active site 768490000769 hypothetical protein; Provisional; Region: PRK11568 768490000770 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 768490000771 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 768490000772 potassium transporter; Provisional; Region: PRK10750 768490000773 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 768490000774 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 768490000775 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 768490000776 FAD binding domain; Region: FAD_binding_4; pfam01565 768490000777 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 768490000778 Biotin operon repressor [Transcription]; Region: BirA; COG1654 768490000779 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 768490000780 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 768490000781 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 768490000782 pantothenate kinase; Provisional; Region: PRK05439 768490000783 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 768490000784 ATP-binding site [chemical binding]; other site 768490000785 CoA-binding site [chemical binding]; other site 768490000786 Mg2+-binding site [ion binding]; other site 768490000787 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768490000788 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490000789 Coenzyme A binding pocket [chemical binding]; other site 768490000790 elongation factor Tu; Reviewed; Region: PRK00049 768490000791 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 768490000792 G1 box; other site 768490000793 GEF interaction site [polypeptide binding]; other site 768490000794 GTP/Mg2+ binding site [chemical binding]; other site 768490000795 Switch I region; other site 768490000796 G2 box; other site 768490000797 G3 box; other site 768490000798 Switch II region; other site 768490000799 G4 box; other site 768490000800 G5 box; other site 768490000801 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 768490000802 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 768490000803 Antibiotic Binding Site [chemical binding]; other site 768490000804 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 768490000805 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 768490000806 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 768490000807 putative homodimer interface [polypeptide binding]; other site 768490000808 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 768490000809 heterodimer interface [polypeptide binding]; other site 768490000810 homodimer interface [polypeptide binding]; other site 768490000811 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 768490000812 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 768490000813 23S rRNA interface [nucleotide binding]; other site 768490000814 L7/L12 interface [polypeptide binding]; other site 768490000815 putative thiostrepton binding site; other site 768490000816 L25 interface [polypeptide binding]; other site 768490000817 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 768490000818 mRNA/rRNA interface [nucleotide binding]; other site 768490000819 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 768490000820 23S rRNA interface [nucleotide binding]; other site 768490000821 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 768490000822 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 768490000823 core dimer interface [polypeptide binding]; other site 768490000824 peripheral dimer interface [polypeptide binding]; other site 768490000825 L10 interface [polypeptide binding]; other site 768490000826 L11 interface [polypeptide binding]; other site 768490000827 putative EF-Tu interaction site [polypeptide binding]; other site 768490000828 putative EF-G interaction site [polypeptide binding]; other site 768490000829 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 768490000830 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 768490000831 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 768490000832 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 768490000833 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 768490000834 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 768490000835 RPB3 interaction site [polypeptide binding]; other site 768490000836 RPB1 interaction site [polypeptide binding]; other site 768490000837 RPB11 interaction site [polypeptide binding]; other site 768490000838 RPB10 interaction site [polypeptide binding]; other site 768490000839 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 768490000840 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 768490000841 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 768490000842 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 768490000843 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 768490000844 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 768490000845 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 768490000846 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 768490000847 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 768490000848 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 768490000849 DNA binding site [nucleotide binding] 768490000850 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 768490000851 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768490000852 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490000853 Coenzyme A binding pocket [chemical binding]; other site 768490000854 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 768490000855 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768490000856 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490000857 ATP binding site [chemical binding]; other site 768490000858 Mg2+ binding site [ion binding]; other site 768490000859 G-X-G motif; other site 768490000860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 768490000861 active site 768490000862 phosphorylation site [posttranslational modification] 768490000863 intermolecular recognition site; other site 768490000864 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 768490000865 active site 768490000866 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 768490000867 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768490000868 FeS/SAM binding site; other site 768490000869 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 768490000870 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 768490000871 ThiS interaction site; other site 768490000872 putative active site [active] 768490000873 tetramer interface [polypeptide binding]; other site 768490000874 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 768490000875 thiS-thiF/thiG interaction site; other site 768490000876 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 768490000877 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 768490000878 ATP binding site [chemical binding]; other site 768490000879 substrate interface [chemical binding]; other site 768490000880 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 768490000881 thiamine phosphate binding site [chemical binding]; other site 768490000882 active site 768490000883 pyrophosphate binding site [ion binding]; other site 768490000884 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 768490000885 ThiC-associated domain; Region: ThiC-associated; pfam13667 768490000886 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 768490000887 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 768490000888 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 768490000889 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 768490000890 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 768490000891 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 768490000892 putative NADH binding site [chemical binding]; other site 768490000893 putative active site [active] 768490000894 nudix motif; other site 768490000895 putative metal binding site [ion binding]; other site 768490000896 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 768490000897 substrate binding site [chemical binding]; other site 768490000898 active site 768490000899 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 768490000900 Active_site [active] 768490000901 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 768490000902 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 768490000903 IHF dimer interface [polypeptide binding]; other site 768490000904 IHF - DNA interface [nucleotide binding]; other site 768490000905 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 768490000906 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 768490000907 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 768490000908 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 768490000909 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 768490000910 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 768490000911 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 768490000912 purine monophosphate binding site [chemical binding]; other site 768490000913 dimer interface [polypeptide binding]; other site 768490000914 putative catalytic residues [active] 768490000915 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 768490000916 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 768490000917 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 768490000918 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 768490000919 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 768490000920 Na binding site [ion binding]; other site 768490000921 Predicted membrane protein [Function unknown]; Region: COG3162 768490000922 acetyl-CoA synthetase; Provisional; Region: PRK00174 768490000923 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 768490000924 active site 768490000925 CoA binding site [chemical binding]; other site 768490000926 acyl-activating enzyme (AAE) consensus motif; other site 768490000927 AMP binding site [chemical binding]; other site 768490000928 acetate binding site [chemical binding]; other site 768490000929 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 768490000930 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 768490000931 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 768490000932 active site clefts [active] 768490000933 zinc binding site [ion binding]; other site 768490000934 dimer interface [polypeptide binding]; other site 768490000935 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 768490000936 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 768490000937 Sulfate transporter family; Region: Sulfate_transp; pfam00916 768490000938 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 768490000939 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 768490000940 P-loop; other site 768490000941 Magnesium ion binding site [ion binding]; other site 768490000942 replicative DNA helicase; Region: DnaB; TIGR00665 768490000943 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 768490000944 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 768490000945 Walker A motif; other site 768490000946 ATP binding site [chemical binding]; other site 768490000947 Walker B motif; other site 768490000948 DNA binding loops [nucleotide binding] 768490000949 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 768490000950 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 768490000951 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 768490000952 Helix-turn-helix domain; Region: HTH_36; pfam13730 768490000953 Domain of unknown function (DUF1845); Region: DUF1845; pfam08900 768490000954 DNA topoisomerase III; Provisional; Region: PRK07726 768490000955 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 768490000956 active site 768490000957 putative interdomain interaction site [polypeptide binding]; other site 768490000958 putative metal-binding site [ion binding]; other site 768490000959 putative nucleotide binding site [chemical binding]; other site 768490000960 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 768490000961 domain I; other site 768490000962 DNA binding groove [nucleotide binding] 768490000963 phosphate binding site [ion binding]; other site 768490000964 domain II; other site 768490000965 domain III; other site 768490000966 nucleotide binding site [chemical binding]; other site 768490000967 catalytic site [active] 768490000968 domain IV; other site 768490000969 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 768490000970 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 768490000971 active site 768490000972 iron coordination sites [ion binding]; other site 768490000973 substrate binding pocket [chemical binding]; other site 768490000974 Domain of unknown function (DUF955); Region: DUF955; pfam06114 768490000975 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 768490000976 Part of AAA domain; Region: AAA_19; pfam13245 768490000977 Family description; Region: UvrD_C_2; pfam13538 768490000978 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 768490000979 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 768490000980 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768490000981 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768490000982 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 768490000983 Restriction endonuclease; Region: Mrr_cat; pfam04471 768490000984 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 768490000985 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 768490000986 integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747 768490000987 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 768490000988 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 768490000989 Protein of unknown function (DUF3262); Region: DUF3262; pfam11660 768490000990 Protein of unknown function (DUF2976); Region: DUF2976; cl12739 768490000991 Protein of unknown function (DUF3487); Region: DUF3487; pfam11990 768490000992 Protein of unknown function (DUF2895); Region: DUF2895; pfam11444 768490000993 Protein of unknown function (DUF3438); Region: DUF3438; pfam11920 768490000994 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 768490000995 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 768490000996 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 768490000997 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 768490000998 Protein of unknown function (DUF1525); Region: DUF1525; pfam07511 768490000999 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 768490001000 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 768490001001 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 768490001002 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768490001003 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768490001004 Walker A/P-loop; other site 768490001005 ATP binding site [chemical binding]; other site 768490001006 RES domain; Region: RES; smart00953 768490001007 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 768490001008 Integrase; Region: Integrase_1; pfam12835 768490001009 Protein of unknown function (DUF3085); Region: DUF3085; pfam11284 768490001010 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 768490001011 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 768490001012 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 768490001013 HlyD family secretion protein; Region: HlyD; pfam00529 768490001014 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768490001015 HlyD family secretion protein; Region: HlyD_3; pfam13437 768490001016 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 768490001017 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 768490001018 putative active site [active] 768490001019 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768490001020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768490001021 Walker A/P-loop; other site 768490001022 ATP binding site [chemical binding]; other site 768490001023 Q-loop/lid; other site 768490001024 ABC transporter signature motif; other site 768490001025 Walker B; other site 768490001026 D-loop; other site 768490001027 H-loop/switch region; other site 768490001028 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768490001029 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768490001030 dimer interface [polypeptide binding]; other site 768490001031 phosphorylation site [posttranslational modification] 768490001032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490001033 ATP binding site [chemical binding]; other site 768490001034 Mg2+ binding site [ion binding]; other site 768490001035 G-X-G motif; other site 768490001036 Response regulator receiver domain; Region: Response_reg; pfam00072 768490001037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490001038 active site 768490001039 phosphorylation site [posttranslational modification] 768490001040 intermolecular recognition site; other site 768490001041 dimerization interface [polypeptide binding]; other site 768490001042 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 768490001043 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 768490001044 BetR domain; Region: BetR; pfam08667 768490001045 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 768490001046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490001047 active site 768490001048 phosphorylation site [posttranslational modification] 768490001049 intermolecular recognition site; other site 768490001050 dimerization interface [polypeptide binding]; other site 768490001051 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 768490001052 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 768490001053 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 768490001054 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 768490001055 active site 768490001056 catalytic residues [active] 768490001057 DNA binding site [nucleotide binding] 768490001058 Int/Topo IB signature motif; other site 768490001059 putative transcriptional regulator; Provisional; Region: PRK11640 768490001060 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768490001061 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 768490001062 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 768490001063 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 768490001064 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 768490001065 DsbD alpha interface [polypeptide binding]; other site 768490001066 catalytic residues [active] 768490001067 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 768490001068 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 768490001069 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 768490001070 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 768490001071 Aspartase; Region: Aspartase; cd01357 768490001072 active sites [active] 768490001073 tetramer interface [polypeptide binding]; other site 768490001074 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 768490001075 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 768490001076 oligomerisation interface [polypeptide binding]; other site 768490001077 mobile loop; other site 768490001078 roof hairpin; other site 768490001079 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 768490001080 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 768490001081 ring oligomerisation interface [polypeptide binding]; other site 768490001082 ATP/Mg binding site [chemical binding]; other site 768490001083 stacking interactions; other site 768490001084 hinge regions; other site 768490001085 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 768490001086 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 768490001087 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768490001088 FeS/SAM binding site; other site 768490001089 elongation factor P; Validated; Region: PRK00529 768490001090 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 768490001091 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 768490001092 RNA binding site [nucleotide binding]; other site 768490001093 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 768490001094 RNA binding site [nucleotide binding]; other site 768490001095 entericidin A; Provisional; Region: PRK09810 768490001096 Predicted small secreted protein [Function unknown]; Region: COG5510 768490001097 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 768490001098 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 768490001099 Iron-sulfur protein interface; other site 768490001100 proximal quinone binding site [chemical binding]; other site 768490001101 C-subunit interface; other site 768490001102 distal quinone binding site; other site 768490001103 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 768490001104 D-subunit interface [polypeptide binding]; other site 768490001105 Iron-sulfur protein interface; other site 768490001106 proximal quinone binding site [chemical binding]; other site 768490001107 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 768490001108 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 768490001109 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 768490001110 L-aspartate oxidase; Provisional; Region: PRK06175 768490001111 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 768490001112 poxB regulator PoxA; Provisional; Region: PRK09350 768490001113 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 768490001114 motif 1; other site 768490001115 dimer interface [polypeptide binding]; other site 768490001116 active site 768490001117 motif 2; other site 768490001118 motif 3; other site 768490001119 putative mechanosensitive channel protein; Provisional; Region: PRK10929 768490001120 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 768490001121 Mechanosensitive ion channel; Region: MS_channel; pfam00924 768490001122 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 768490001123 GTPase RsgA; Reviewed; Region: PRK12288 768490001124 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 768490001125 RNA binding site [nucleotide binding]; other site 768490001126 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 768490001127 GTPase/Zn-binding domain interface [polypeptide binding]; other site 768490001128 GTP/Mg2+ binding site [chemical binding]; other site 768490001129 G4 box; other site 768490001130 G5 box; other site 768490001131 G1 box; other site 768490001132 Switch I region; other site 768490001133 G2 box; other site 768490001134 G3 box; other site 768490001135 Switch II region; other site 768490001136 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 768490001137 catalytic site [active] 768490001138 putative active site [active] 768490001139 putative substrate binding site [chemical binding]; other site 768490001140 dimer interface [polypeptide binding]; other site 768490001141 epoxyqueuosine reductase; Region: TIGR00276 768490001142 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 768490001143 putative carbohydrate kinase; Provisional; Region: PRK10565 768490001144 Uncharacterized conserved protein [Function unknown]; Region: COG0062 768490001145 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 768490001146 putative substrate binding site [chemical binding]; other site 768490001147 putative ATP binding site [chemical binding]; other site 768490001148 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 768490001149 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 768490001150 AMIN domain; Region: AMIN; pfam11741 768490001151 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 768490001152 active site 768490001153 metal binding site [ion binding]; metal-binding site 768490001154 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768490001155 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 768490001156 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490001157 ATP binding site [chemical binding]; other site 768490001158 Mg2+ binding site [ion binding]; other site 768490001159 G-X-G motif; other site 768490001160 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 768490001161 ATP binding site [chemical binding]; other site 768490001162 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 768490001163 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 768490001164 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 768490001165 bacterial Hfq-like; Region: Hfq; cd01716 768490001166 hexamer interface [polypeptide binding]; other site 768490001167 Sm1 motif; other site 768490001168 RNA binding site [nucleotide binding]; other site 768490001169 Sm2 motif; other site 768490001170 GTPase HflX; Provisional; Region: PRK11058 768490001171 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 768490001172 HflX GTPase family; Region: HflX; cd01878 768490001173 G1 box; other site 768490001174 GTP/Mg2+ binding site [chemical binding]; other site 768490001175 Switch I region; other site 768490001176 G2 box; other site 768490001177 G3 box; other site 768490001178 Switch II region; other site 768490001179 G4 box; other site 768490001180 G5 box; other site 768490001181 FtsH protease regulator HflK; Provisional; Region: PRK10930 768490001182 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 768490001183 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 768490001184 FtsH protease regulator HflC; Provisional; Region: PRK11029 768490001185 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 768490001186 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 768490001187 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 768490001188 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 768490001189 GDP-binding site [chemical binding]; other site 768490001190 ACT binding site; other site 768490001191 IMP binding site; other site 768490001192 transcriptional repressor NsrR; Provisional; Region: PRK11014 768490001193 Rrf2 family protein; Region: rrf2_super; TIGR00738 768490001194 exoribonuclease R; Provisional; Region: PRK11642 768490001195 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 768490001196 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 768490001197 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 768490001198 RNB domain; Region: RNB; pfam00773 768490001199 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 768490001200 RNA binding site [nucleotide binding]; other site 768490001201 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 768490001202 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 768490001203 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 768490001204 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 768490001205 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 768490001206 FAD binding site [chemical binding]; other site 768490001207 substrate binding site [chemical binding]; other site 768490001208 catalytic residues [active] 768490001209 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 768490001210 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 768490001211 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 768490001212 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 768490001213 esterase; Provisional; Region: PRK10566 768490001214 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 768490001215 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 768490001216 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 768490001217 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 768490001218 dimer interface [polypeptide binding]; other site 768490001219 ssDNA binding site [nucleotide binding]; other site 768490001220 tetramer (dimer of dimers) interface [polypeptide binding]; other site 768490001221 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 768490001222 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 768490001223 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 768490001224 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 768490001225 Protein of unknown function, DUF488; Region: DUF488; cl01246 768490001226 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 768490001227 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 768490001228 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 768490001229 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 768490001230 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 768490001231 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 768490001232 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 768490001233 Hemerythrin-like domain; Region: Hr-like; cd12108 768490001234 Fe binding site [ion binding]; other site 768490001235 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 768490001236 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 768490001237 active site 768490001238 metal binding site [ion binding]; metal-binding site 768490001239 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 768490001240 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 768490001241 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 768490001242 active site 768490001243 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl17398 768490001244 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 768490001245 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 768490001246 Domain of unknown function DUF21; Region: DUF21; pfam01595 768490001247 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 768490001248 Transporter associated domain; Region: CorC_HlyC; smart01091 768490001249 methionine sulfoxide reductase A; Provisional; Region: PRK00058 768490001250 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 768490001251 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768490001252 Surface antigen; Region: Bac_surface_Ag; pfam01103 768490001253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 768490001254 Family of unknown function (DUF490); Region: DUF490; pfam04357 768490001255 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 768490001256 putative active site pocket [active] 768490001257 dimerization interface [polypeptide binding]; other site 768490001258 putative catalytic residue [active] 768490001259 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 768490001260 dimer interface [polypeptide binding]; other site 768490001261 substrate binding site [chemical binding]; other site 768490001262 metal binding sites [ion binding]; metal-binding site 768490001263 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 768490001264 ligand binding site [chemical binding]; other site 768490001265 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768490001266 dimerization interface [polypeptide binding]; other site 768490001267 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768490001268 dimer interface [polypeptide binding]; other site 768490001269 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 768490001270 putative CheW interface [polypeptide binding]; other site 768490001271 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 768490001272 AMP binding site [chemical binding]; other site 768490001273 metal binding site [ion binding]; metal-binding site 768490001274 active site 768490001275 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 768490001276 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 768490001277 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768490001278 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768490001279 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 768490001280 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 768490001281 arginine repressor; Provisional; Region: PRK05066 768490001282 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 768490001283 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 768490001284 malate dehydrogenase; Provisional; Region: PRK05086 768490001285 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 768490001286 NAD binding site [chemical binding]; other site 768490001287 dimerization interface [polypeptide binding]; other site 768490001288 Substrate binding site [chemical binding]; other site 768490001289 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 768490001290 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 768490001291 Protein of unknown function (DUF447); Region: DUF447; cl17801 768490001292 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 768490001293 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 768490001294 substrate binding pocket [chemical binding]; other site 768490001295 chain length determination region; other site 768490001296 substrate-Mg2+ binding site; other site 768490001297 catalytic residues [active] 768490001298 aspartate-rich region 1; other site 768490001299 active site lid residues [active] 768490001300 aspartate-rich region 2; other site 768490001301 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 768490001302 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 768490001303 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768490001304 EamA-like transporter family; Region: EamA; pfam00892 768490001305 GTPase CgtA; Reviewed; Region: obgE; PRK12298 768490001306 GTP1/OBG; Region: GTP1_OBG; pfam01018 768490001307 Obg GTPase; Region: Obg; cd01898 768490001308 G1 box; other site 768490001309 GTP/Mg2+ binding site [chemical binding]; other site 768490001310 Switch I region; other site 768490001311 G2 box; other site 768490001312 G3 box; other site 768490001313 Switch II region; other site 768490001314 G4 box; other site 768490001315 G5 box; other site 768490001316 sensor protein BasS/PmrB; Provisional; Region: PRK10755 768490001317 HAMP domain; Region: HAMP; pfam00672 768490001318 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768490001319 dimer interface [polypeptide binding]; other site 768490001320 phosphorylation site [posttranslational modification] 768490001321 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490001322 ATP binding site [chemical binding]; other site 768490001323 Mg2+ binding site [ion binding]; other site 768490001324 G-X-G motif; other site 768490001325 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 768490001326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490001327 active site 768490001328 phosphorylation site [posttranslational modification] 768490001329 intermolecular recognition site; other site 768490001330 dimerization interface [polypeptide binding]; other site 768490001331 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768490001332 DNA binding site [nucleotide binding] 768490001333 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 768490001334 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 768490001335 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 768490001336 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 768490001337 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 768490001338 RNA-binding protein YhbY; Provisional; Region: PRK10343 768490001339 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 768490001340 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490001341 S-adenosylmethionine binding site [chemical binding]; other site 768490001342 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 768490001343 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768490001344 Walker A motif; other site 768490001345 ATP binding site [chemical binding]; other site 768490001346 Walker B motif; other site 768490001347 arginine finger; other site 768490001348 Peptidase family M41; Region: Peptidase_M41; pfam01434 768490001349 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 768490001350 dihydropteroate synthase; Region: DHPS; TIGR01496 768490001351 substrate binding pocket [chemical binding]; other site 768490001352 dimer interface [polypeptide binding]; other site 768490001353 inhibitor binding site; inhibition site 768490001354 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 768490001355 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 768490001356 active site 768490001357 substrate binding site [chemical binding]; other site 768490001358 metal binding site [ion binding]; metal-binding site 768490001359 Preprotein translocase SecG subunit; Region: SecG; pfam03840 768490001360 ribosome maturation protein RimP; Reviewed; Region: PRK00092 768490001361 Sm and related proteins; Region: Sm_like; cl00259 768490001362 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 768490001363 putative oligomer interface [polypeptide binding]; other site 768490001364 putative RNA binding site [nucleotide binding]; other site 768490001365 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 768490001366 NusA N-terminal domain; Region: NusA_N; pfam08529 768490001367 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 768490001368 RNA binding site [nucleotide binding]; other site 768490001369 homodimer interface [polypeptide binding]; other site 768490001370 NusA-like KH domain; Region: KH_5; pfam13184 768490001371 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 768490001372 G-X-X-G motif; other site 768490001373 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 768490001374 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 768490001375 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 768490001376 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 768490001377 translation initiation factor IF-2; Region: IF-2; TIGR00487 768490001378 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 768490001379 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 768490001380 G1 box; other site 768490001381 putative GEF interaction site [polypeptide binding]; other site 768490001382 GTP/Mg2+ binding site [chemical binding]; other site 768490001383 Switch I region; other site 768490001384 G2 box; other site 768490001385 G3 box; other site 768490001386 Switch II region; other site 768490001387 G4 box; other site 768490001388 G5 box; other site 768490001389 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 768490001390 Translation-initiation factor 2; Region: IF-2; pfam11987 768490001391 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 768490001392 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 768490001393 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 768490001394 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 768490001395 RNA binding site [nucleotide binding]; other site 768490001396 active site 768490001397 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 768490001398 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 768490001399 16S/18S rRNA binding site [nucleotide binding]; other site 768490001400 S13e-L30e interaction site [polypeptide binding]; other site 768490001401 25S rRNA binding site [nucleotide binding]; other site 768490001402 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 768490001403 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 768490001404 RNase E interface [polypeptide binding]; other site 768490001405 trimer interface [polypeptide binding]; other site 768490001406 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 768490001407 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 768490001408 RNase E interface [polypeptide binding]; other site 768490001409 trimer interface [polypeptide binding]; other site 768490001410 active site 768490001411 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 768490001412 putative nucleic acid binding region [nucleotide binding]; other site 768490001413 G-X-X-G motif; other site 768490001414 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 768490001415 RNA binding site [nucleotide binding]; other site 768490001416 domain interface; other site 768490001417 lipoprotein NlpI; Provisional; Region: PRK11189 768490001418 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768490001419 binding surface 768490001420 TPR motif; other site 768490001421 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 768490001422 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 768490001423 ATP binding site [chemical binding]; other site 768490001424 Mg++ binding site [ion binding]; other site 768490001425 motif III; other site 768490001426 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768490001427 nucleotide binding region [chemical binding]; other site 768490001428 ATP-binding site [chemical binding]; other site 768490001429 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 768490001430 putative RNA binding site [nucleotide binding]; other site 768490001431 putative inner membrane protein; Provisional; Region: PRK11099 768490001432 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 768490001433 CPxP motif; other site 768490001434 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768490001435 non-specific DNA binding site [nucleotide binding]; other site 768490001436 salt bridge; other site 768490001437 sequence-specific DNA binding site [nucleotide binding]; other site 768490001438 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490001439 putative substrate translocation pore; other site 768490001440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490001441 hypothetical protein; Provisional; Region: PRK10508 768490001442 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 768490001443 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 768490001444 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 768490001445 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 768490001446 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768490001447 HlyD family secretion protein; Region: HlyD_3; pfam13437 768490001448 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 768490001449 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 768490001450 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 768490001451 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 768490001452 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768490001453 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 768490001454 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 768490001455 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 768490001456 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 768490001457 active site 768490001458 putative protease; Provisional; Region: PRK15447 768490001459 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 768490001460 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 768490001461 Peptidase family U32; Region: Peptidase_U32; pfam01136 768490001462 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 768490001463 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490001464 Coenzyme A binding pocket [chemical binding]; other site 768490001465 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 768490001466 GIY-YIG motif/motif A; other site 768490001467 putative active site [active] 768490001468 putative metal binding site [ion binding]; other site 768490001469 hypothetical protein; Provisional; Region: PRK03467 768490001470 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 768490001471 NADH(P)-binding; Region: NAD_binding_10; pfam13460 768490001472 NAD binding site [chemical binding]; other site 768490001473 active site 768490001474 putative hydrolase; Provisional; Region: PRK02113 768490001475 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 768490001476 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 768490001477 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 768490001478 trimer interface [polypeptide binding]; other site 768490001479 active site 768490001480 substrate binding site [chemical binding]; other site 768490001481 CoA binding site [chemical binding]; other site 768490001482 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 768490001483 AAA domain; Region: AAA_18; pfam13238 768490001484 active site 768490001485 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 768490001486 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 768490001487 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 768490001488 active site 768490001489 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 768490001490 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768490001491 Walker A/P-loop; other site 768490001492 ATP binding site [chemical binding]; other site 768490001493 Q-loop/lid; other site 768490001494 ABC transporter signature motif; other site 768490001495 Walker B; other site 768490001496 D-loop; other site 768490001497 H-loop/switch region; other site 768490001498 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 768490001499 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768490001500 Walker A/P-loop; other site 768490001501 ATP binding site [chemical binding]; other site 768490001502 Q-loop/lid; other site 768490001503 ABC transporter signature motif; other site 768490001504 Walker B; other site 768490001505 D-loop; other site 768490001506 H-loop/switch region; other site 768490001507 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768490001508 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 768490001509 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 768490001510 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845 768490001511 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 768490001512 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 768490001513 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768490001514 DNA-binding site [nucleotide binding]; DNA binding site 768490001515 UTRA domain; Region: UTRA; pfam07702 768490001516 Predicted permease; Region: DUF318; cl17795 768490001517 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 768490001518 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 768490001519 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768490001520 FeS/SAM binding site; other site 768490001521 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 768490001522 ATP cone domain; Region: ATP-cone; pfam03477 768490001523 Class III ribonucleotide reductase; Region: RNR_III; cd01675 768490001524 effector binding site; other site 768490001525 active site 768490001526 Zn binding site [ion binding]; other site 768490001527 glycine loop; other site 768490001528 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490001529 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490001530 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768490001531 putative effector binding pocket; other site 768490001532 dimerization interface [polypeptide binding]; other site 768490001533 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 768490001534 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 768490001535 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 768490001536 Ca binding site [ion binding]; other site 768490001537 active site 768490001538 catalytic site [active] 768490001539 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 768490001540 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 768490001541 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768490001542 active site turn [active] 768490001543 phosphorylation site [posttranslational modification] 768490001544 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768490001545 trehalose repressor; Provisional; Region: treR; PRK09492 768490001546 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768490001547 DNA binding site [nucleotide binding] 768490001548 domain linker motif; other site 768490001549 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 768490001550 dimerization interface [polypeptide binding]; other site 768490001551 ligand binding site [chemical binding]; other site 768490001552 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 768490001553 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 768490001554 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768490001555 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 768490001556 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768490001557 motif II; other site 768490001558 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 768490001559 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 768490001560 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 768490001561 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 768490001562 active site 768490001563 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 768490001564 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 768490001565 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 768490001566 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 768490001567 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 768490001568 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 768490001569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 768490001570 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 768490001571 Uncharacterized conserved protein [Function unknown]; Region: COG2308 768490001572 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 768490001573 homotrimer interaction site [polypeptide binding]; other site 768490001574 putative active site [active] 768490001575 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 768490001576 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 768490001577 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 768490001578 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 768490001579 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 768490001580 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 768490001581 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 768490001582 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 768490001583 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 768490001584 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 768490001585 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 768490001586 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 768490001587 RNase E inhibitor protein; Provisional; Region: PRK11191 768490001588 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 768490001589 active site 768490001590 dinuclear metal binding site [ion binding]; other site 768490001591 dimerization interface [polypeptide binding]; other site 768490001592 choline dehydrogenase; Validated; Region: PRK02106 768490001593 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768490001594 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 768490001595 Acyltransferase family; Region: Acyl_transf_3; pfam01757 768490001596 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768490001597 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490001598 Coenzyme A binding pocket [chemical binding]; other site 768490001599 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 768490001600 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 768490001601 HIGH motif; other site 768490001602 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 768490001603 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 768490001604 active site 768490001605 KMSKS motif; other site 768490001606 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 768490001607 tRNA binding surface [nucleotide binding]; other site 768490001608 anticodon binding site; other site 768490001609 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 768490001610 DNA polymerase III subunit chi; Validated; Region: PRK05728 768490001611 multifunctional aminopeptidase A; Provisional; Region: PRK00913 768490001612 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 768490001613 interface (dimer of trimers) [polypeptide binding]; other site 768490001614 Substrate-binding/catalytic site; other site 768490001615 Zn-binding sites [ion binding]; other site 768490001616 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 768490001617 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 768490001618 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 768490001619 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 768490001620 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 768490001621 active site clefts [active] 768490001622 zinc binding site [ion binding]; other site 768490001623 dimer interface [polypeptide binding]; other site 768490001624 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768490001625 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768490001626 non-specific DNA binding site [nucleotide binding]; other site 768490001627 salt bridge; other site 768490001628 sequence-specific DNA binding site [nucleotide binding]; other site 768490001629 HipA N-terminal domain; Region: Couple_hipA; pfam13657 768490001630 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 768490001631 HipA-like N-terminal domain; Region: HipA_N; pfam07805 768490001632 HipA-like C-terminal domain; Region: HipA_C; pfam07804 768490001633 Z1 domain; Region: Z1; pfam10593 768490001634 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 768490001635 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 768490001636 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 768490001637 cofactor binding site; other site 768490001638 DNA binding site [nucleotide binding] 768490001639 substrate interaction site [chemical binding]; other site 768490001640 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 768490001641 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 768490001642 additional DNA contacts [nucleotide binding]; other site 768490001643 mismatch recognition site; other site 768490001644 active site 768490001645 zinc binding site [ion binding]; other site 768490001646 DNA intercalation site [nucleotide binding]; other site 768490001647 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 768490001648 beta-galactosidase; Region: BGL; TIGR03356 768490001649 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 768490001650 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768490001651 active site turn [active] 768490001652 phosphorylation site [posttranslational modification] 768490001653 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 768490001654 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768490001655 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768490001656 DNA binding site [nucleotide binding] 768490001657 domain linker motif; other site 768490001658 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 768490001659 dimerization interface (closed form) [polypeptide binding]; other site 768490001660 ligand binding site [chemical binding]; other site 768490001661 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 768490001662 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 768490001663 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 768490001664 Uncharacterized small protein [Function unknown]; Region: COG2879 768490001665 carbon starvation protein A; Provisional; Region: PRK15015 768490001666 Carbon starvation protein CstA; Region: CstA; pfam02554 768490001667 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 768490001668 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 768490001669 Beta-lactamase; Region: Beta-lactamase; pfam00144 768490001670 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 768490001671 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 768490001672 active site 768490001673 dimer interface [polypeptide binding]; other site 768490001674 non-prolyl cis peptide bond; other site 768490001675 insertion regions; other site 768490001676 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 768490001677 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 768490001678 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490001679 Coenzyme A binding pocket [chemical binding]; other site 768490001680 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 768490001681 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 768490001682 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 768490001683 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768490001684 non-specific DNA binding site [nucleotide binding]; other site 768490001685 salt bridge; other site 768490001686 sequence-specific DNA binding site [nucleotide binding]; other site 768490001687 PQQ-like domain; Region: PQQ_2; pfam13360 768490001688 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 768490001689 putative transporter; Provisional; Region: PRK11043 768490001690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490001691 putative substrate translocation pore; other site 768490001692 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 768490001693 Cytochrome P450; Region: p450; cl12078 768490001694 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 768490001695 Predicted flavoprotein [General function prediction only]; Region: COG0431 768490001696 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768490001697 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 768490001698 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 768490001699 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 768490001700 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 768490001701 active site 768490001702 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 768490001703 acyl-CoA synthetase; Validated; Region: PRK05850 768490001704 acyl-activating enzyme (AAE) consensus motif; other site 768490001705 active site 768490001706 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 768490001707 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768490001708 thioester reductase domain; Region: Thioester-redct; TIGR01746 768490001709 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 768490001710 putative NAD(P) binding site [chemical binding]; other site 768490001711 active site 768490001712 putative substrate binding site [chemical binding]; other site 768490001713 Condensation domain; Region: Condensation; pfam00668 768490001714 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 768490001715 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 768490001716 acyl-activating enzyme (AAE) consensus motif; other site 768490001717 AMP binding site [chemical binding]; other site 768490001718 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768490001719 Condensation domain; Region: Condensation; pfam00668 768490001720 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 768490001721 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 768490001722 acyl-activating enzyme (AAE) consensus motif; other site 768490001723 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 768490001724 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 768490001725 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 768490001726 AMP binding site [chemical binding]; other site 768490001727 Methyltransferase domain; Region: Methyltransf_23; pfam13489 768490001728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490001729 S-adenosylmethionine binding site [chemical binding]; other site 768490001730 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768490001731 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768490001732 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 768490001733 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490001734 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490001735 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 768490001736 L,D-transpeptidase; Provisional; Region: PRK10260 768490001737 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 768490001738 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 768490001739 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 768490001740 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 768490001741 Gram-negative bacterial tonB protein; Region: TonB; cl10048 768490001742 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 768490001743 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768490001744 N-terminal plug; other site 768490001745 ligand-binding site [chemical binding]; other site 768490001746 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 768490001747 Putative catalytic domain, repeat 1, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_1; cd09106 768490001748 PLD-like domain; Region: PLDc_2; pfam13091 768490001749 putative active site [active] 768490001750 putative catalytic site [active] 768490001751 Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_2; cd09107 768490001752 PLD-like domain; Region: PLDc_2; pfam13091 768490001753 putative active site [active] 768490001754 putative catalytic site [active] 768490001755 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 768490001756 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768490001757 inhibitor-cofactor binding pocket; inhibition site 768490001758 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490001759 catalytic residue [active] 768490001760 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490001761 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490001762 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768490001763 dimerization interface [polypeptide binding]; other site 768490001764 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 768490001765 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 768490001766 active site 768490001767 NAD binding site [chemical binding]; other site 768490001768 metal binding site [ion binding]; metal-binding site 768490001769 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768490001770 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768490001771 DNA binding residues [nucleotide binding] 768490001772 dimerization interface [polypeptide binding]; other site 768490001773 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 768490001774 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 768490001775 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 768490001776 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 768490001777 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 768490001778 PGAP1-like protein; Region: PGAP1; pfam07819 768490001779 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 768490001780 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 768490001781 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 768490001782 active site 768490001783 Zn binding site [ion binding]; other site 768490001784 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768490001785 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768490001786 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768490001787 DNA binding residues [nucleotide binding] 768490001788 dimerization interface [polypeptide binding]; other site 768490001789 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 768490001790 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 768490001791 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 768490001792 classical (c) SDRs; Region: SDR_c; cd05233 768490001793 NAD(P) binding site [chemical binding]; other site 768490001794 active site 768490001795 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 768490001796 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 768490001797 classical (c) SDRs; Region: SDR_c; cd05233 768490001798 NAD(P) binding site [chemical binding]; other site 768490001799 active site 768490001800 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 768490001801 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768490001802 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 768490001803 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 768490001804 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 768490001805 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 768490001806 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 768490001807 NAD binding site [chemical binding]; other site 768490001808 catalytic residues [active] 768490001809 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 768490001810 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 768490001811 tetramer interface [polypeptide binding]; other site 768490001812 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 768490001813 tetramer interface [polypeptide binding]; other site 768490001814 active site 768490001815 metal binding site [ion binding]; metal-binding site 768490001816 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 768490001817 putative substrate binding pocket [chemical binding]; other site 768490001818 trimer interface [polypeptide binding]; other site 768490001819 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 768490001820 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Region: HpaI; TIGR02311 768490001821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490001822 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 768490001823 putative substrate translocation pore; other site 768490001824 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 768490001825 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768490001826 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490001827 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 768490001828 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 768490001829 Flavin Reductases; Region: FlaRed; cl00801 768490001830 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 768490001831 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 768490001832 Transcriptional regulators [Transcription]; Region: FadR; COG2186 768490001833 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768490001834 DNA-binding site [nucleotide binding]; DNA binding site 768490001835 FCD domain; Region: FCD; pfam07729 768490001836 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 768490001837 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 768490001838 NAD binding site [chemical binding]; other site 768490001839 homotetramer interface [polypeptide binding]; other site 768490001840 homodimer interface [polypeptide binding]; other site 768490001841 active site 768490001842 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 768490001843 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 768490001844 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 768490001845 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 768490001846 putative active site pocket [active] 768490001847 metal binding site [ion binding]; metal-binding site 768490001848 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 768490001849 Amidohydrolase; Region: Amidohydro_2; pfam04909 768490001850 active site 768490001851 short chain dehydrogenase; Provisional; Region: PRK08628 768490001852 classical (c) SDRs; Region: SDR_c; cd05233 768490001853 NAD(P) binding site [chemical binding]; other site 768490001854 active site 768490001855 Domain of unknown function (DUF718); Region: DUF718; pfam05336 768490001856 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 768490001857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490001858 putative substrate translocation pore; other site 768490001859 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768490001860 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490001861 putative substrate translocation pore; other site 768490001862 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490001863 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490001864 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768490001865 putative effector binding pocket; other site 768490001866 dimerization interface [polypeptide binding]; other site 768490001867 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768490001868 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768490001869 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768490001870 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768490001871 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768490001872 metal binding site [ion binding]; metal-binding site 768490001873 active site 768490001874 I-site; other site 768490001875 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 768490001876 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490001877 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490001878 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 768490001879 putative effector binding pocket; other site 768490001880 putative dimerization interface [polypeptide binding]; other site 768490001881 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768490001882 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768490001883 active site 768490001884 catalytic tetrad [active] 768490001885 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 768490001886 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 768490001887 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490001888 S-adenosylmethionine binding site [chemical binding]; other site 768490001889 DNA polymerase III subunit psi; Validated; Region: PRK06856 768490001890 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 768490001891 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490001892 Coenzyme A binding pocket [chemical binding]; other site 768490001893 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768490001894 non-specific DNA binding site [nucleotide binding]; other site 768490001895 salt bridge; other site 768490001896 sequence-specific DNA binding site [nucleotide binding]; other site 768490001897 HipA N-terminal domain; Region: Couple_hipA; pfam13657 768490001898 HipA-like N-terminal domain; Region: HipA_N; pfam07805 768490001899 HipA-like C-terminal domain; Region: HipA_C; pfam07804 768490001900 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 768490001901 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 768490001902 G1 box; other site 768490001903 putative GEF interaction site [polypeptide binding]; other site 768490001904 GTP/Mg2+ binding site [chemical binding]; other site 768490001905 Switch I region; other site 768490001906 G2 box; other site 768490001907 G3 box; other site 768490001908 Switch II region; other site 768490001909 G4 box; other site 768490001910 G5 box; other site 768490001911 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 768490001912 periplasmic protein; Provisional; Region: PRK10568 768490001913 BON domain; Region: BON; pfam04972 768490001914 BON domain; Region: BON; pfam04972 768490001915 CsbD-like; Region: CsbD; cl17424 768490001916 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 768490001917 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 768490001918 active site 768490001919 nucleophile elbow; other site 768490001920 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 768490001921 active site 768490001922 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 768490001923 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 768490001924 Nucleoside recognition; Region: Gate; pfam07670 768490001925 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 768490001926 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 768490001927 intersubunit interface [polypeptide binding]; other site 768490001928 active site 768490001929 catalytic residue [active] 768490001930 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 768490001931 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 768490001932 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 768490001933 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 768490001934 phosphopentomutase; Provisional; Region: PRK05362 768490001935 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 768490001936 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 768490001937 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 768490001938 Bacterial virulence factor haemolysin; Region: SMP_2; cl11479 768490001939 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 768490001940 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 768490001941 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768490001942 motif II; other site 768490001943 DNA repair protein RadA; Provisional; Region: PRK11823 768490001944 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 768490001945 Walker A motif/ATP binding site; other site 768490001946 ATP binding site [chemical binding]; other site 768490001947 Walker B motif; other site 768490001948 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 768490001949 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768490001950 non-specific DNA binding site [nucleotide binding]; other site 768490001951 salt bridge; other site 768490001952 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 768490001953 sequence-specific DNA binding site [nucleotide binding]; other site 768490001954 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768490001955 active site 768490001956 nucleotide binding site [chemical binding]; other site 768490001957 HIGH motif; other site 768490001958 KMSKS motif; other site 768490001959 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 768490001960 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 768490001961 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 768490001962 putative NAD(P) binding site [chemical binding]; other site 768490001963 dimer interface [polypeptide binding]; other site 768490001964 LysR family transcriptional regulator; Provisional; Region: PRK14997 768490001965 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490001966 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768490001967 putative effector binding pocket; other site 768490001968 dimerization interface [polypeptide binding]; other site 768490001969 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 768490001970 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768490001971 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768490001972 ABC transporter; Region: ABC_tran_2; pfam12848 768490001973 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768490001974 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 768490001975 ligand binding site [chemical binding]; other site 768490001976 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 768490001977 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 768490001978 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768490001979 metal binding site [ion binding]; metal-binding site 768490001980 active site 768490001981 I-site; other site 768490001982 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 768490001983 lytic murein transglycosylase; Provisional; Region: PRK11619 768490001984 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768490001985 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768490001986 catalytic residue [active] 768490001987 Trp operon repressor; Provisional; Region: PRK01381 768490001988 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 768490001989 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768490001990 catalytic core [active] 768490001991 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 768490001992 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490001993 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 768490001994 hypothetical protein; Provisional; Region: PRK10756 768490001995 CreA protein; Region: CreA; pfam05981 768490001996 two-component response regulator; Provisional; Region: PRK11173 768490001997 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490001998 active site 768490001999 phosphorylation site [posttranslational modification] 768490002000 intermolecular recognition site; other site 768490002001 dimerization interface [polypeptide binding]; other site 768490002002 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768490002003 DNA binding site [nucleotide binding] 768490002004 putative RNA methyltransferase; Provisional; Region: PRK10433 768490002005 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 768490002006 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 768490002007 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 768490002008 putative catalytic residues [active] 768490002009 putative nucleotide binding site [chemical binding]; other site 768490002010 putative aspartate binding site [chemical binding]; other site 768490002011 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 768490002012 dimer interface [polypeptide binding]; other site 768490002013 putative threonine allosteric regulatory site; other site 768490002014 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 768490002015 putative threonine allosteric regulatory site; other site 768490002016 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 768490002017 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 768490002018 homoserine kinase; Provisional; Region: PRK01212 768490002019 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 768490002020 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 768490002021 threonine synthase; Validated; Region: PRK09225 768490002022 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 768490002023 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768490002024 catalytic residue [active] 768490002025 hypothetical protein; Validated; Region: PRK02101 768490002026 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 768490002027 amino acid carrier protein; Region: agcS; TIGR00835 768490002028 transaldolase-like protein; Provisional; Region: PTZ00411 768490002029 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 768490002030 active site 768490002031 dimer interface [polypeptide binding]; other site 768490002032 catalytic residue [active] 768490002033 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 768490002034 MPT binding site; other site 768490002035 trimer interface [polypeptide binding]; other site 768490002036 metabolite-proton symporter; Region: 2A0106; TIGR00883 768490002037 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490002038 putative substrate translocation pore; other site 768490002039 hypothetical protein; Provisional; Region: PRK10659 768490002040 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 768490002041 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 768490002042 nucleotide binding site [chemical binding]; other site 768490002043 chaperone protein DnaJ; Provisional; Region: PRK10767 768490002044 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 768490002045 HSP70 interaction site [polypeptide binding]; other site 768490002046 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 768490002047 substrate binding site [polypeptide binding]; other site 768490002048 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 768490002049 Zn binding sites [ion binding]; other site 768490002050 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 768490002051 dimer interface [polypeptide binding]; other site 768490002052 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 768490002053 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 768490002054 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490002055 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 768490002056 putative dimerization interface [polypeptide binding]; other site 768490002057 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 768490002058 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 768490002059 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 768490002060 active site 768490002061 Riboflavin kinase; Region: Flavokinase; smart00904 768490002062 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 768490002063 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768490002064 active site 768490002065 HIGH motif; other site 768490002066 nucleotide binding site [chemical binding]; other site 768490002067 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 768490002068 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 768490002069 active site 768490002070 KMSKS motif; other site 768490002071 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 768490002072 tRNA binding surface [nucleotide binding]; other site 768490002073 anticodon binding site; other site 768490002074 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 768490002075 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 768490002076 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 768490002077 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 768490002078 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 768490002079 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 768490002080 transcriptional regulator; Provisional; Region: PRK10632 768490002081 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490002082 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768490002083 putative effector binding pocket; other site 768490002084 dimerization interface [polypeptide binding]; other site 768490002085 Pyoverdine/dityrosine biosynthesis protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: DIT1; COG3207 768490002086 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 768490002087 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 768490002088 substrate binding pocket [chemical binding]; other site 768490002089 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 768490002090 active site 768490002091 iron coordination sites [ion binding]; other site 768490002092 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 768490002093 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 768490002094 active site 768490002095 TDP-binding site; other site 768490002096 acceptor substrate-binding pocket; other site 768490002097 dihydrodipicolinate reductase; Provisional; Region: PRK00048 768490002098 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 768490002099 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 768490002100 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 768490002101 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 768490002102 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 768490002103 catalytic site [active] 768490002104 subunit interface [polypeptide binding]; other site 768490002105 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 768490002106 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 768490002107 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 768490002108 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 768490002109 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 768490002110 ATP-grasp domain; Region: ATP-grasp_4; cl17255 768490002111 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 768490002112 IMP binding site; other site 768490002113 dimer interface [polypeptide binding]; other site 768490002114 interdomain contacts; other site 768490002115 partial ornithine binding site; other site 768490002116 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 768490002117 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768490002118 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 768490002119 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 768490002120 TrkA-N domain; Region: TrkA_N; pfam02254 768490002121 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 768490002122 Uncharacterized conserved protein [Function unknown]; Region: COG2966 768490002123 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 768490002124 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 768490002125 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 768490002126 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 768490002127 folate binding site [chemical binding]; other site 768490002128 NADP+ binding site [chemical binding]; other site 768490002129 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 768490002130 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 768490002131 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 768490002132 active site 768490002133 metal binding site [ion binding]; metal-binding site 768490002134 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 768490002135 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 768490002136 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 768490002137 S-adenosylmethionine binding site [chemical binding]; other site 768490002138 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 768490002139 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 768490002140 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 768490002141 SurA N-terminal domain; Region: SurA_N; pfam09312 768490002142 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 768490002143 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 768490002144 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 768490002145 OstA-like protein; Region: OstA; pfam03968 768490002146 Organic solvent tolerance protein; Region: OstA_C; pfam04453 768490002147 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 768490002148 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 768490002149 putative metal binding site [ion binding]; other site 768490002150 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 768490002151 HSP70 interaction site [polypeptide binding]; other site 768490002152 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 768490002153 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 768490002154 active site 768490002155 ATP-dependent helicase HepA; Validated; Region: PRK04914 768490002156 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768490002157 ATP binding site [chemical binding]; other site 768490002158 putative Mg++ binding site [ion binding]; other site 768490002159 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768490002160 nucleotide binding region [chemical binding]; other site 768490002161 ATP-binding site [chemical binding]; other site 768490002162 DNA polymerase II; Reviewed; Region: PRK05762 768490002163 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 768490002164 active site 768490002165 catalytic site [active] 768490002166 substrate binding site [chemical binding]; other site 768490002167 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 768490002168 active site 768490002169 metal-binding site 768490002170 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 768490002171 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 768490002172 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 768490002173 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 768490002174 putative valine binding site [chemical binding]; other site 768490002175 dimer interface [polypeptide binding]; other site 768490002176 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 768490002177 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768490002178 PYR/PP interface [polypeptide binding]; other site 768490002179 dimer interface [polypeptide binding]; other site 768490002180 TPP binding site [chemical binding]; other site 768490002181 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768490002182 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 768490002183 TPP-binding site [chemical binding]; other site 768490002184 dimer interface [polypeptide binding]; other site 768490002185 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 768490002186 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768490002187 Walker A/P-loop; other site 768490002188 ATP binding site [chemical binding]; other site 768490002189 Q-loop/lid; other site 768490002190 ABC transporter signature motif; other site 768490002191 Walker B; other site 768490002192 D-loop; other site 768490002193 H-loop/switch region; other site 768490002194 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 768490002195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490002196 putative PBP binding loops; other site 768490002197 ABC-ATPase subunit interface; other site 768490002198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490002199 dimer interface [polypeptide binding]; other site 768490002200 conserved gate region; other site 768490002201 putative PBP binding loops; other site 768490002202 ABC-ATPase subunit interface; other site 768490002203 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 768490002204 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 768490002205 transcriptional regulator SgrR; Provisional; Region: PRK13626 768490002206 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 768490002207 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 768490002208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490002209 sugar efflux transporter; Region: 2A0120; TIGR00899 768490002210 putative substrate translocation pore; other site 768490002211 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 768490002212 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 768490002213 transmembrane helices; other site 768490002214 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 768490002215 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 768490002216 substrate binding site [chemical binding]; other site 768490002217 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 768490002218 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 768490002219 substrate binding site [chemical binding]; other site 768490002220 ligand binding site [chemical binding]; other site 768490002221 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 768490002222 tartrate dehydrogenase; Region: TTC; TIGR02089 768490002223 2-isopropylmalate synthase; Validated; Region: PRK00915 768490002224 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 768490002225 active site 768490002226 catalytic residues [active] 768490002227 metal binding site [ion binding]; metal-binding site 768490002228 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 768490002229 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 768490002230 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490002231 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 768490002232 putative substrate binding pocket [chemical binding]; other site 768490002233 putative dimerization interface [polypeptide binding]; other site 768490002234 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 768490002235 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 768490002236 acyl-activating enzyme (AAE) consensus motif; other site 768490002237 putative AMP binding site [chemical binding]; other site 768490002238 putative active site [active] 768490002239 putative CoA binding site [chemical binding]; other site 768490002240 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 768490002241 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768490002242 PYR/PP interface [polypeptide binding]; other site 768490002243 dimer interface [polypeptide binding]; other site 768490002244 TPP binding site [chemical binding]; other site 768490002245 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768490002246 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 768490002247 TPP-binding site [chemical binding]; other site 768490002248 dimer interface [polypeptide binding]; other site 768490002249 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 768490002250 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 768490002251 putative valine binding site [chemical binding]; other site 768490002252 dimer interface [polypeptide binding]; other site 768490002253 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 768490002254 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 768490002255 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768490002256 DNA binding site [nucleotide binding] 768490002257 domain linker motif; other site 768490002258 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 768490002259 dimerization interface [polypeptide binding]; other site 768490002260 ligand binding site [chemical binding]; other site 768490002261 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 768490002262 cell division protein MraZ; Reviewed; Region: PRK00326 768490002263 MraZ protein; Region: MraZ; pfam02381 768490002264 MraZ protein; Region: MraZ; pfam02381 768490002265 MraW methylase family; Region: Methyltransf_5; pfam01795 768490002266 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 768490002267 cell division protein FtsL; Provisional; Region: PRK10772 768490002268 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 768490002269 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 768490002270 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 768490002271 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 768490002272 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 768490002273 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768490002274 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768490002275 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 768490002276 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 768490002277 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768490002278 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768490002279 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 768490002280 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 768490002281 Mg++ binding site [ion binding]; other site 768490002282 putative catalytic motif [active] 768490002283 putative substrate binding site [chemical binding]; other site 768490002284 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 768490002285 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768490002286 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768490002287 cell division protein FtsW; Provisional; Region: PRK10774 768490002288 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 768490002289 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 768490002290 active site 768490002291 homodimer interface [polypeptide binding]; other site 768490002292 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 768490002293 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 768490002294 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768490002295 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768490002296 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 768490002297 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 768490002298 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 768490002299 cell division protein FtsQ; Provisional; Region: PRK10775 768490002300 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 768490002301 Cell division protein FtsQ; Region: FtsQ; pfam03799 768490002302 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 768490002303 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768490002304 Cell division protein FtsA; Region: FtsA; pfam14450 768490002305 cell division protein FtsZ; Validated; Region: PRK09330 768490002306 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 768490002307 nucleotide binding site [chemical binding]; other site 768490002308 SulA interaction site; other site 768490002309 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 768490002310 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 768490002311 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4701 768490002312 SecA regulator SecM; Provisional; Region: PRK02943 768490002313 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 768490002314 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 768490002315 SEC-C motif; Region: SEC-C; pfam02810 768490002316 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 768490002317 active site 768490002318 8-oxo-dGMP binding site [chemical binding]; other site 768490002319 nudix motif; other site 768490002320 metal binding site [ion binding]; metal-binding site 768490002321 DNA gyrase inhibitor; Reviewed; Region: PRK00418 768490002322 hypothetical protein; Provisional; Region: PRK05287 768490002323 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 768490002324 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 768490002325 CoA-binding site [chemical binding]; other site 768490002326 ATP-binding [chemical binding]; other site 768490002327 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 768490002328 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 768490002329 active site 768490002330 type IV pilin biogenesis protein; Provisional; Region: PRK10573 768490002331 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 768490002332 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 768490002333 hypothetical protein; Provisional; Region: PRK10436 768490002334 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 768490002335 Walker A motif; other site 768490002336 ATP binding site [chemical binding]; other site 768490002337 Walker B motif; other site 768490002338 putative major pilin subunit; Provisional; Region: PRK10574 768490002339 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 768490002340 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 768490002341 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 768490002342 dimerization interface [polypeptide binding]; other site 768490002343 active site 768490002344 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 768490002345 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 768490002346 amidase catalytic site [active] 768490002347 Zn binding residues [ion binding]; other site 768490002348 substrate binding site [chemical binding]; other site 768490002349 regulatory protein AmpE; Provisional; Region: PRK10987 768490002350 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 768490002351 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768490002352 inhibitor-cofactor binding pocket; inhibition site 768490002353 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490002354 catalytic residue [active] 768490002355 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 768490002356 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 768490002357 Cl- selectivity filter; other site 768490002358 Cl- binding residues [ion binding]; other site 768490002359 pore gating glutamate residue; other site 768490002360 dimer interface [polypeptide binding]; other site 768490002361 H+/Cl- coupling transport residue; other site 768490002362 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 768490002363 hypothetical protein; Provisional; Region: PRK10578 768490002364 UPF0126 domain; Region: UPF0126; pfam03458 768490002365 UPF0126 domain; Region: UPF0126; pfam03458 768490002366 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 768490002367 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 768490002368 cobalamin binding residues [chemical binding]; other site 768490002369 putative BtuC binding residues; other site 768490002370 dimer interface [polypeptide binding]; other site 768490002371 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 768490002372 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 768490002373 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 768490002374 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 768490002375 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 768490002376 serine endoprotease; Provisional; Region: PRK10942 768490002377 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 768490002378 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 768490002379 protein binding site [polypeptide binding]; other site 768490002380 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 768490002381 protein binding site [polypeptide binding]; other site 768490002382 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 768490002383 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 768490002384 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768490002385 dimerization interface [polypeptide binding]; other site 768490002386 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768490002387 dimer interface [polypeptide binding]; other site 768490002388 phosphorylation site [posttranslational modification] 768490002389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490002390 ATP binding site [chemical binding]; other site 768490002391 Mg2+ binding site [ion binding]; other site 768490002392 G-X-G motif; other site 768490002393 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 768490002394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490002395 active site 768490002396 phosphorylation site [posttranslational modification] 768490002397 intermolecular recognition site; other site 768490002398 dimerization interface [polypeptide binding]; other site 768490002399 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 768490002400 putative binding surface; other site 768490002401 active site 768490002402 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 768490002403 HD domain; Region: HD_4; pfam13328 768490002404 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 768490002405 synthetase active site [active] 768490002406 NTP binding site [chemical binding]; other site 768490002407 metal binding site [ion binding]; metal-binding site 768490002408 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 768490002409 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 768490002410 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 768490002411 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 768490002412 homodimer interface [polypeptide binding]; other site 768490002413 metal binding site [ion binding]; metal-binding site 768490002414 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 768490002415 homodimer interface [polypeptide binding]; other site 768490002416 active site 768490002417 putative chemical substrate binding site [chemical binding]; other site 768490002418 metal binding site [ion binding]; metal-binding site 768490002419 CTP synthetase; Validated; Region: pyrG; PRK05380 768490002420 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 768490002421 Catalytic site [active] 768490002422 active site 768490002423 UTP binding site [chemical binding]; other site 768490002424 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 768490002425 active site 768490002426 putative oxyanion hole; other site 768490002427 catalytic triad [active] 768490002428 enolase; Provisional; Region: eno; PRK00077 768490002429 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 768490002430 dimer interface [polypeptide binding]; other site 768490002431 metal binding site [ion binding]; metal-binding site 768490002432 substrate binding pocket [chemical binding]; other site 768490002433 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 768490002434 methionine gamma-lyase; Provisional; Region: PRK07503 768490002435 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 768490002436 homodimer interface [polypeptide binding]; other site 768490002437 substrate-cofactor binding pocket; other site 768490002438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490002439 catalytic residue [active] 768490002440 putative proline-specific permease; Provisional; Region: proY; PRK10580 768490002441 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 768490002442 active sites [active] 768490002443 tetramer interface [polypeptide binding]; other site 768490002444 urocanate hydratase; Provisional; Region: PRK05414 768490002445 benzoate transport; Region: 2A0115; TIGR00895 768490002446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490002447 putative substrate translocation pore; other site 768490002448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490002449 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 768490002450 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 768490002451 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 768490002452 active site 768490002453 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 768490002454 Flavodoxin; Region: Flavodoxin_1; pfam00258 768490002455 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 768490002456 FAD binding pocket [chemical binding]; other site 768490002457 FAD binding motif [chemical binding]; other site 768490002458 catalytic residues [active] 768490002459 NAD binding pocket [chemical binding]; other site 768490002460 phosphate binding motif [ion binding]; other site 768490002461 beta-alpha-beta structure motif; other site 768490002462 sulfite reductase subunit beta; Provisional; Region: PRK13504 768490002463 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 768490002464 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 768490002465 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 768490002466 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 768490002467 Active Sites [active] 768490002468 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 768490002469 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 768490002470 metal binding site [ion binding]; metal-binding site 768490002471 siroheme synthase; Provisional; Region: cysG; PRK10637 768490002472 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 768490002473 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 768490002474 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 768490002475 active site 768490002476 SAM binding site [chemical binding]; other site 768490002477 homodimer interface [polypeptide binding]; other site 768490002478 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 768490002479 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 768490002480 Active Sites [active] 768490002481 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 768490002482 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 768490002483 CysD dimerization site [polypeptide binding]; other site 768490002484 G1 box; other site 768490002485 putative GEF interaction site [polypeptide binding]; other site 768490002486 GTP/Mg2+ binding site [chemical binding]; other site 768490002487 Switch I region; other site 768490002488 G2 box; other site 768490002489 G3 box; other site 768490002490 Switch II region; other site 768490002491 G4 box; other site 768490002492 G5 box; other site 768490002493 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 768490002494 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 768490002495 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 768490002496 ligand-binding site [chemical binding]; other site 768490002497 hypothetical protein; Provisional; Region: PRK10726 768490002498 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 768490002499 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 768490002500 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 768490002501 substrate binding site; other site 768490002502 dimer interface; other site 768490002503 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 768490002504 homotrimer interaction site [polypeptide binding]; other site 768490002505 zinc binding site [ion binding]; other site 768490002506 CDP-binding sites; other site 768490002507 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 768490002508 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 768490002509 Permutation of conserved domain; other site 768490002510 active site 768490002511 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 768490002512 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 768490002513 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490002514 S-adenosylmethionine binding site [chemical binding]; other site 768490002515 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 768490002516 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768490002517 Peptidase family M23; Region: Peptidase_M23; pfam01551 768490002518 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 768490002519 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 768490002520 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768490002521 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 768490002522 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768490002523 DNA binding residues [nucleotide binding] 768490002524 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 768490002525 MutS domain I; Region: MutS_I; pfam01624 768490002526 MutS domain II; Region: MutS_II; pfam05188 768490002527 MutS domain III; Region: MutS_III; pfam05192 768490002528 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 768490002529 Walker A/P-loop; other site 768490002530 ATP binding site [chemical binding]; other site 768490002531 Q-loop/lid; other site 768490002532 ABC transporter signature motif; other site 768490002533 Walker B; other site 768490002534 D-loop; other site 768490002535 H-loop/switch region; other site 768490002536 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 768490002537 active site 768490002538 P-loop; other site 768490002539 phosphorylation site [posttranslational modification] 768490002540 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 768490002541 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 768490002542 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 768490002543 beta-galactosidase; Region: BGL; TIGR03356 768490002544 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 768490002545 Cupin domain; Region: Cupin_2; pfam07883 768490002546 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490002547 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 768490002548 putative active site [active] 768490002549 YdjC motif; other site 768490002550 Mg binding site [ion binding]; other site 768490002551 putative homodimer interface [polypeptide binding]; other site 768490002552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490002553 putative substrate translocation pore; other site 768490002554 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768490002555 hypothetical protein; Validated; Region: PRK03661 768490002556 recombinase A; Provisional; Region: recA; PRK09354 768490002557 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 768490002558 hexamer interface [polypeptide binding]; other site 768490002559 Walker A motif; other site 768490002560 ATP binding site [chemical binding]; other site 768490002561 Walker B motif; other site 768490002562 recombination regulator RecX; Reviewed; Region: recX; PRK00117 768490002563 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 768490002564 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 768490002565 motif 1; other site 768490002566 active site 768490002567 motif 2; other site 768490002568 motif 3; other site 768490002569 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 768490002570 DHHA1 domain; Region: DHHA1; pfam02272 768490002571 carbon storage regulator; Provisional; Region: PRK01712 768490002572 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 768490002573 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768490002574 motif II; other site 768490002575 Predicted membrane protein [Function unknown]; Region: COG1238 768490002576 glutamate--cysteine ligase; Provisional; Region: PRK02107 768490002577 S-ribosylhomocysteinase; Provisional; Region: PRK02260 768490002578 hypothetical protein; Provisional; Region: PRK11573 768490002579 Domain of unknown function DUF21; Region: DUF21; pfam01595 768490002580 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 768490002581 Transporter associated domain; Region: CorC_HlyC; smart01091 768490002582 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 768490002583 signal recognition particle protein; Provisional; Region: PRK10867 768490002584 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 768490002585 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 768490002586 P loop; other site 768490002587 GTP binding site [chemical binding]; other site 768490002588 Signal peptide binding domain; Region: SRP_SPB; pfam02978 768490002589 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 768490002590 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 768490002591 RimM N-terminal domain; Region: RimM; pfam01782 768490002592 PRC-barrel domain; Region: PRC; pfam05239 768490002593 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 768490002594 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 768490002595 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 768490002596 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 768490002597 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 768490002598 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 768490002599 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 768490002600 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 768490002601 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 768490002602 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 768490002603 major tail tube protein; Provisional; Region: FII; PHA02600 768490002604 major tail sheath protein; Provisional; Region: FI; PHA02560 768490002605 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 768490002606 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 768490002607 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 768490002608 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 768490002609 baseplate assembly protein; Provisional; Region: J; PHA02568 768490002610 baseplate wedge subunit; Provisional; Region: W; PHA02516 768490002611 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 768490002612 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 768490002613 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 768490002614 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 768490002615 catalytic residues [active] 768490002616 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 768490002617 DksA-like zinc finger domain containing protein; Region: PHA00080 768490002618 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 768490002619 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 768490002620 Protein of unknown function, DUF481; Region: DUF481; cl01213 768490002621 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 768490002622 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 768490002623 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 768490002624 Chorismate mutase type II; Region: CM_2; cl00693 768490002625 prephenate dehydrogenase; Validated; Region: PRK08507 768490002626 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 768490002627 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 768490002628 Prephenate dehydratase; Region: PDT; pfam00800 768490002629 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 768490002630 putative L-Phe binding site [chemical binding]; other site 768490002631 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 768490002632 30S subunit binding site; other site 768490002633 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 768490002634 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 768490002635 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768490002636 RNA binding surface [nucleotide binding]; other site 768490002637 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 768490002638 active site 768490002639 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 768490002640 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 768490002641 protein disaggregation chaperone; Provisional; Region: PRK10865 768490002642 Clp amino terminal domain; Region: Clp_N; pfam02861 768490002643 Clp amino terminal domain; Region: Clp_N; pfam02861 768490002644 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768490002645 Walker A motif; other site 768490002646 ATP binding site [chemical binding]; other site 768490002647 Walker B motif; other site 768490002648 arginine finger; other site 768490002649 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768490002650 Walker A motif; other site 768490002651 ATP binding site [chemical binding]; other site 768490002652 Walker B motif; other site 768490002653 arginine finger; other site 768490002654 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 768490002655 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 768490002656 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 768490002657 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 768490002658 putative acyl-acceptor binding pocket; other site 768490002659 Phosphopantetheine attachment site; Region: PP-binding; cl09936 768490002660 acyl carrier protein; Provisional; Region: PRK05350 768490002661 Predicted membrane protein [Function unknown]; Region: COG4648 768490002662 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 768490002663 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 768490002664 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 768490002665 acyl-activating enzyme (AAE) consensus motif; other site 768490002666 acyl-activating enzyme (AAE) consensus motif; other site 768490002667 AMP binding site [chemical binding]; other site 768490002668 active site 768490002669 CoA binding site [chemical binding]; other site 768490002670 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 768490002671 active site 2 [active] 768490002672 active site 1 [active] 768490002673 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 768490002674 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 768490002675 Ligand binding site; other site 768490002676 Putative Catalytic site; other site 768490002677 DXD motif; other site 768490002678 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 768490002679 putative acyl-acceptor binding pocket; other site 768490002680 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 768490002681 active site 768490002682 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 768490002683 Predicted exporter [General function prediction only]; Region: COG4258 768490002684 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 768490002685 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 768490002686 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 768490002687 dimer interface [polypeptide binding]; other site 768490002688 active site 768490002689 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 768490002690 putative active site 1 [active] 768490002691 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 768490002692 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 768490002693 NAD(P) binding site [chemical binding]; other site 768490002694 homotetramer interface [polypeptide binding]; other site 768490002695 homodimer interface [polypeptide binding]; other site 768490002696 active site 768490002697 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 768490002698 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 768490002699 dimer interface [polypeptide binding]; other site 768490002700 active site 768490002701 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768490002702 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768490002703 active site 768490002704 catalytic tetrad [active] 768490002705 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490002706 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490002707 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768490002708 dimerization interface [polypeptide binding]; other site 768490002709 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768490002710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490002711 putative substrate translocation pore; other site 768490002712 hypothetical protein; Provisional; Region: PRK05421 768490002713 putative catalytic site [active] 768490002714 putative phosphate binding site [ion binding]; other site 768490002715 putative metal binding site [ion binding]; other site 768490002716 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 768490002717 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768490002718 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768490002719 catalytic residue [active] 768490002720 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768490002721 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768490002722 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 768490002723 Methyltransferase domain; Region: Methyltransf_23; pfam13489 768490002724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490002725 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 768490002726 RNA/DNA hybrid binding site [nucleotide binding]; other site 768490002727 active site 768490002728 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 768490002729 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 768490002730 active site 768490002731 catalytic site [active] 768490002732 substrate binding site [chemical binding]; other site 768490002733 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 768490002734 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 768490002735 Na binding site [ion binding]; other site 768490002736 putative substrate binding site [chemical binding]; other site 768490002737 Transcriptional regulators [Transcription]; Region: FadR; COG2186 768490002738 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768490002739 DNA-binding site [nucleotide binding]; DNA binding site 768490002740 FCD domain; Region: FCD; pfam07729 768490002741 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 768490002742 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 768490002743 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 768490002744 active site 768490002745 catalytic site [active] 768490002746 tetramer interface [polypeptide binding]; other site 768490002747 Helix-turn-helix domain; Region: HTH_37; pfam13744 768490002748 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 768490002749 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 768490002750 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768490002751 N-terminal plug; other site 768490002752 ligand-binding site [chemical binding]; other site 768490002753 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 768490002754 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768490002755 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 768490002756 IucA / IucC family; Region: IucA_IucC; pfam04183 768490002757 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 768490002758 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 768490002759 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 768490002760 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 768490002761 IucA / IucC family; Region: IucA_IucC; pfam04183 768490002762 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 768490002763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490002764 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768490002765 putative substrate translocation pore; other site 768490002766 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 768490002767 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 768490002768 FAD binding pocket [chemical binding]; other site 768490002769 FAD binding motif [chemical binding]; other site 768490002770 phosphate binding motif [ion binding]; other site 768490002771 NAD binding pocket [chemical binding]; other site 768490002772 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 768490002773 amidase; Provisional; Region: PRK09201 768490002774 Amidase; Region: Amidase; cl11426 768490002775 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 768490002776 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 768490002777 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 768490002778 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 768490002779 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768490002780 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 768490002781 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768490002782 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768490002783 substrate binding pocket [chemical binding]; other site 768490002784 membrane-bound complex binding site; other site 768490002785 hinge residues; other site 768490002786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490002787 dimer interface [polypeptide binding]; other site 768490002788 conserved gate region; other site 768490002789 putative PBP binding loops; other site 768490002790 ABC-ATPase subunit interface; other site 768490002791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 768490002792 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490002793 ABC-ATPase subunit interface; other site 768490002794 putative PBP binding loops; other site 768490002795 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 768490002796 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 768490002797 Walker A/P-loop; other site 768490002798 ATP binding site [chemical binding]; other site 768490002799 Q-loop/lid; other site 768490002800 ABC transporter signature motif; other site 768490002801 Walker B; other site 768490002802 D-loop; other site 768490002803 H-loop/switch region; other site 768490002804 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 768490002805 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768490002806 catalytic residue [active] 768490002807 allantoate amidohydrolase; Reviewed; Region: PRK09290 768490002808 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 768490002809 active site 768490002810 metal binding site [ion binding]; metal-binding site 768490002811 dimer interface [polypeptide binding]; other site 768490002812 OHCU decarboxylase; Region: UraD_2; TIGR03180 768490002813 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 768490002814 active site 768490002815 homotetramer interface [polypeptide binding]; other site 768490002816 xanthine permease; Region: pbuX; TIGR03173 768490002817 C-N hydrolase family amidase; Provisional; Region: PRK10438 768490002818 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 768490002819 putative active site [active] 768490002820 catalytic triad [active] 768490002821 dimer interface [polypeptide binding]; other site 768490002822 multimer interface [polypeptide binding]; other site 768490002823 methionine aminotransferase; Validated; Region: PRK09082 768490002824 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768490002825 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490002826 homodimer interface [polypeptide binding]; other site 768490002827 catalytic residue [active] 768490002828 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 768490002829 intersubunit interface [polypeptide binding]; other site 768490002830 active site 768490002831 Zn2+ binding site [ion binding]; other site 768490002832 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 768490002833 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 768490002834 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 768490002835 Cupin domain; Region: Cupin_2; cl17218 768490002836 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 768490002837 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 768490002838 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 768490002839 Hok/gef family; Region: HOK_GEF; pfam01848 768490002840 Hok/gef family; Region: HOK_GEF; pfam01848 768490002841 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 768490002842 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 768490002843 active site 768490002844 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 768490002845 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 768490002846 dimer interface [polypeptide binding]; other site 768490002847 active site 768490002848 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 768490002849 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 768490002850 putative active site [active] 768490002851 putative dimer interface [polypeptide binding]; other site 768490002852 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 768490002853 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 768490002854 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768490002855 E3 interaction surface; other site 768490002856 lipoyl attachment site [posttranslational modification]; other site 768490002857 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 768490002858 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 768490002859 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 768490002860 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 768490002861 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 768490002862 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 768490002863 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 768490002864 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768490002865 catalytic loop [active] 768490002866 iron binding site [ion binding]; other site 768490002867 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 768490002868 FAD binding pocket [chemical binding]; other site 768490002869 FAD binding motif [chemical binding]; other site 768490002870 phosphate binding motif [ion binding]; other site 768490002871 beta-alpha-beta structure motif; other site 768490002872 NAD binding pocket [chemical binding]; other site 768490002873 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 768490002874 ApbE family; Region: ApbE; pfam02424 768490002875 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991 768490002876 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 768490002877 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 768490002878 active site 768490002879 catalytic site [active] 768490002880 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 768490002881 active site 768490002882 DNA polymerase IV; Validated; Region: PRK02406 768490002883 DNA binding site [nucleotide binding] 768490002884 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 768490002885 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 768490002886 metal binding site [ion binding]; metal-binding site 768490002887 dimer interface [polypeptide binding]; other site 768490002888 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768490002889 active site 768490002890 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 768490002891 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 768490002892 gamma-glutamyl kinase; Provisional; Region: PRK05429 768490002893 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 768490002894 nucleotide binding site [chemical binding]; other site 768490002895 homotetrameric interface [polypeptide binding]; other site 768490002896 putative phosphate binding site [ion binding]; other site 768490002897 putative allosteric binding site; other site 768490002898 PUA domain; Region: PUA; pfam01472 768490002899 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 768490002900 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 768490002901 putative catalytic cysteine [active] 768490002902 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318 768490002903 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768490002904 Zn2+ binding site [ion binding]; other site 768490002905 Mg2+ binding site [ion binding]; other site 768490002906 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 768490002907 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768490002908 non-specific DNA binding site [nucleotide binding]; other site 768490002909 salt bridge; other site 768490002910 sequence-specific DNA binding site [nucleotide binding]; other site 768490002911 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 768490002912 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 768490002913 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 768490002914 peptide binding site [polypeptide binding]; other site 768490002915 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 768490002916 Condensation domain; Region: Condensation; pfam00668 768490002917 Nonribosomal peptide synthase; Region: NRPS; pfam08415 768490002918 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 768490002919 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 768490002920 acyl-activating enzyme (AAE) consensus motif; other site 768490002921 AMP binding site [chemical binding]; other site 768490002922 Condensation domain; Region: Condensation; pfam00668 768490002923 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 768490002924 Nonribosomal peptide synthase; Region: NRPS; pfam08415 768490002925 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 768490002926 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 768490002927 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768490002928 Condensation domain; Region: Condensation; pfam00668 768490002929 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 768490002930 Uncharacterized conserved protein [Function unknown]; Region: COG3391 768490002931 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 768490002932 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 768490002933 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 768490002934 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 768490002935 catalytic residues [active] 768490002936 hinge region; other site 768490002937 alpha helical domain; other site 768490002938 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 768490002939 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490002940 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 768490002941 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 768490002942 NAD(P) binding site [chemical binding]; other site 768490002943 catalytic residues [active] 768490002944 leucine export protein LeuE; Provisional; Region: PRK10958 768490002945 tellurite resistance protein TehB; Provisional; Region: PRK12335 768490002946 Domain of unknown function (DUF1971); Region: DUF1971; cl17717 768490002947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490002948 S-adenosylmethionine binding site [chemical binding]; other site 768490002949 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768490002950 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490002951 Coenzyme A binding pocket [chemical binding]; other site 768490002952 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 768490002953 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 768490002954 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 768490002955 C-terminal domain interface [polypeptide binding]; other site 768490002956 GSH binding site (G-site) [chemical binding]; other site 768490002957 dimer interface [polypeptide binding]; other site 768490002958 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 768490002959 N-terminal domain interface [polypeptide binding]; other site 768490002960 dimer interface [polypeptide binding]; other site 768490002961 substrate binding pocket (H-site) [chemical binding]; other site 768490002962 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768490002963 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 768490002964 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490002965 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490002966 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768490002967 dimerization interface [polypeptide binding]; other site 768490002968 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 768490002969 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 768490002970 dimer interface [polypeptide binding]; other site 768490002971 PYR/PP interface [polypeptide binding]; other site 768490002972 TPP binding site [chemical binding]; other site 768490002973 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768490002974 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 768490002975 TPP-binding site [chemical binding]; other site 768490002976 dimer interface [polypeptide binding]; other site 768490002977 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 768490002978 hypothetical protein; Provisional; Region: PRK11667 768490002979 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 768490002980 Domain of unknown function (DUF333); Region: DUF333; pfam03891 768490002981 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 768490002982 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 768490002983 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 768490002984 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 768490002985 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768490002986 active site 768490002987 metal binding site [ion binding]; metal-binding site 768490002988 LysR family transcriptional regulator; Provisional; Region: PRK14997 768490002989 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490002990 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 768490002991 putative effector binding pocket; other site 768490002992 putative dimerization interface [polypeptide binding]; other site 768490002993 Pirin-related protein [General function prediction only]; Region: COG1741 768490002994 Pirin; Region: Pirin; pfam02678 768490002995 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 768490002996 Isochorismatase family; Region: Isochorismatase; pfam00857 768490002997 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 768490002998 catalytic triad [active] 768490002999 dimer interface [polypeptide binding]; other site 768490003000 conserved cis-peptide bond; other site 768490003001 aconitate hydratase, mitochondrial; Region: aconitase_mito; TIGR01340 768490003002 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 768490003003 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768490003004 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768490003005 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 768490003006 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 768490003007 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768490003008 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768490003009 salt bridge; other site 768490003010 non-specific DNA binding site [nucleotide binding]; other site 768490003011 sequence-specific DNA binding site [nucleotide binding]; other site 768490003012 Methyltransferase domain; Region: Methyltransf_31; pfam13847 768490003013 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490003014 S-adenosylmethionine binding site [chemical binding]; other site 768490003015 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 768490003016 amphipathic channel; other site 768490003017 Asn-Pro-Ala signature motifs; other site 768490003018 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 768490003019 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 768490003020 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 768490003021 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 768490003022 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490003023 Coenzyme A binding pocket [chemical binding]; other site 768490003024 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 768490003025 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 768490003026 putative ligand binding residues [chemical binding]; other site 768490003027 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768490003028 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490003029 Coenzyme A binding pocket [chemical binding]; other site 768490003030 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 768490003031 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 768490003032 ADP binding site [chemical binding]; other site 768490003033 magnesium binding site [ion binding]; other site 768490003034 putative shikimate binding site; other site 768490003035 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768490003036 active site 768490003037 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768490003038 catalytic tetrad [active] 768490003039 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768490003040 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768490003041 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768490003042 Helix-turn-helix domain; Region: HTH_18; pfam12833 768490003043 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490003044 SnoaL-like domain; Region: SnoaL_2; pfam12680 768490003045 hypothetical protein; Provisional; Region: PRK10380 768490003046 hypothetical protein; Provisional; Region: PRK10579 768490003047 recombination associated protein; Reviewed; Region: rdgC; PRK00321 768490003048 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768490003049 dimerization interface [polypeptide binding]; other site 768490003050 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768490003051 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768490003052 putative active site [active] 768490003053 heme pocket [chemical binding]; other site 768490003054 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768490003055 dimer interface [polypeptide binding]; other site 768490003056 phosphorylation site [posttranslational modification] 768490003057 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490003058 ATP binding site [chemical binding]; other site 768490003059 Mg2+ binding site [ion binding]; other site 768490003060 G-X-G motif; other site 768490003061 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 768490003062 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490003063 active site 768490003064 phosphorylation site [posttranslational modification] 768490003065 intermolecular recognition site; other site 768490003066 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 768490003067 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768490003068 Walker A/P-loop; other site 768490003069 ATP binding site [chemical binding]; other site 768490003070 Q-loop/lid; other site 768490003071 ABC transporter signature motif; other site 768490003072 Walker B; other site 768490003073 D-loop; other site 768490003074 H-loop/switch region; other site 768490003075 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768490003076 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768490003077 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768490003078 TM-ABC transporter signature motif; other site 768490003079 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 768490003080 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 768490003081 putative ligand binding site [chemical binding]; other site 768490003082 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 768490003083 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 768490003084 intersubunit interface [polypeptide binding]; other site 768490003085 active site 768490003086 zinc binding site [ion binding]; other site 768490003087 Na+ binding site [ion binding]; other site 768490003088 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 768490003089 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768490003090 substrate binding site [chemical binding]; other site 768490003091 ATP binding site [chemical binding]; other site 768490003092 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768490003093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490003094 active site 768490003095 phosphorylation site [posttranslational modification] 768490003096 intermolecular recognition site; other site 768490003097 dimerization interface [polypeptide binding]; other site 768490003098 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768490003099 DNA binding site [nucleotide binding] 768490003100 fructokinase; Reviewed; Region: PRK09557 768490003101 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768490003102 nucleotide binding site [chemical binding]; other site 768490003103 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 768490003104 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 768490003105 putative active site [active] 768490003106 transcriptional antiterminator BglG; Provisional; Region: PRK09772 768490003107 CAT RNA binding domain; Region: CAT_RBD; smart01061 768490003108 PRD domain; Region: PRD; pfam00874 768490003109 PRD domain; Region: PRD; pfam00874 768490003110 ethanolamine permease; Region: 2A0305; TIGR00908 768490003111 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768490003112 AAA domain; Region: AAA_23; pfam13476 768490003113 Walker A/P-loop; other site 768490003114 ATP binding site [chemical binding]; other site 768490003115 Q-loop/lid; other site 768490003116 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768490003117 ABC transporter signature motif; other site 768490003118 Walker B; other site 768490003119 D-loop; other site 768490003120 H-loop/switch region; other site 768490003121 exonuclease subunit SbcD; Provisional; Region: PRK10966 768490003122 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 768490003123 active site 768490003124 metal binding site [ion binding]; metal-binding site 768490003125 DNA binding site [nucleotide binding] 768490003126 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 768490003127 transcriptional regulator PhoB; Provisional; Region: PRK10161 768490003128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490003129 active site 768490003130 phosphorylation site [posttranslational modification] 768490003131 intermolecular recognition site; other site 768490003132 dimerization interface [polypeptide binding]; other site 768490003133 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768490003134 DNA binding site [nucleotide binding] 768490003135 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 768490003136 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 768490003137 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768490003138 putative active site [active] 768490003139 heme pocket [chemical binding]; other site 768490003140 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768490003141 dimer interface [polypeptide binding]; other site 768490003142 phosphorylation site [posttranslational modification] 768490003143 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490003144 ATP binding site [chemical binding]; other site 768490003145 Mg2+ binding site [ion binding]; other site 768490003146 G-X-G motif; other site 768490003147 PBP superfamily domain; Region: PBP_like_2; cl17296 768490003148 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 768490003149 substrate binding site [chemical binding]; other site 768490003150 THF binding site; other site 768490003151 zinc-binding site [ion binding]; other site 768490003152 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 768490003153 putative proline-specific permease; Provisional; Region: proY; PRK10580 768490003154 Spore germination protein; Region: Spore_permease; cl17796 768490003155 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 768490003156 Mechanosensitive ion channel; Region: MS_channel; pfam00924 768490003157 maltodextrin glucosidase; Provisional; Region: PRK10785 768490003158 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 768490003159 homodimer interface [polypeptide binding]; other site 768490003160 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 768490003161 active site 768490003162 homodimer interface [polypeptide binding]; other site 768490003163 catalytic site [active] 768490003164 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 768490003165 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 768490003166 peroxidase; Provisional; Region: PRK15000 768490003167 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 768490003168 dimer interface [polypeptide binding]; other site 768490003169 decamer (pentamer of dimers) interface [polypeptide binding]; other site 768490003170 catalytic triad [active] 768490003171 peroxidatic and resolving cysteines [active] 768490003172 Protein of unknown function, DUF479; Region: DUF479; cl01203 768490003173 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 768490003174 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 768490003175 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 768490003176 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 768490003177 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 768490003178 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 768490003179 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 768490003180 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 768490003181 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 768490003182 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 768490003183 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 768490003184 Protein export membrane protein; Region: SecD_SecF; pfam02355 768490003185 hypothetical protein; Provisional; Region: PRK11530 768490003186 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 768490003187 ATP cone domain; Region: ATP-cone; pfam03477 768490003188 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 768490003189 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 768490003190 catalytic motif [active] 768490003191 Zn binding site [ion binding]; other site 768490003192 RibD C-terminal domain; Region: RibD_C; cl17279 768490003193 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 768490003194 homopentamer interface [polypeptide binding]; other site 768490003195 active site 768490003196 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 768490003197 putative RNA binding site [nucleotide binding]; other site 768490003198 thiamine monophosphate kinase; Provisional; Region: PRK05731 768490003199 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 768490003200 ATP binding site [chemical binding]; other site 768490003201 dimerization interface [polypeptide binding]; other site 768490003202 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 768490003203 tetramer interfaces [polypeptide binding]; other site 768490003204 binuclear metal-binding site [ion binding]; other site 768490003205 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768490003206 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768490003207 active site 768490003208 catalytic tetrad [active] 768490003209 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 768490003210 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 768490003211 TPP-binding site; other site 768490003212 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 768490003213 PYR/PP interface [polypeptide binding]; other site 768490003214 dimer interface [polypeptide binding]; other site 768490003215 TPP binding site [chemical binding]; other site 768490003216 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768490003217 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 768490003218 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 768490003219 substrate binding pocket [chemical binding]; other site 768490003220 chain length determination region; other site 768490003221 substrate-Mg2+ binding site; other site 768490003222 catalytic residues [active] 768490003223 aspartate-rich region 1; other site 768490003224 active site lid residues [active] 768490003225 aspartate-rich region 2; other site 768490003226 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 768490003227 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 768490003228 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 768490003229 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 768490003230 Ligand Binding Site [chemical binding]; other site 768490003231 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 768490003232 active site residue [active] 768490003233 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 768490003234 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 768490003235 conserved cys residue [active] 768490003236 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 768490003237 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 768490003238 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 768490003239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 768490003240 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 768490003241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490003242 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768490003243 putative substrate translocation pore; other site 768490003244 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 768490003245 UbiA prenyltransferase family; Region: UbiA; pfam01040 768490003246 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 768490003247 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 768490003248 Subunit I/III interface [polypeptide binding]; other site 768490003249 Subunit III/IV interface [polypeptide binding]; other site 768490003250 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 768490003251 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 768490003252 D-pathway; other site 768490003253 Putative ubiquinol binding site [chemical binding]; other site 768490003254 Low-spin heme (heme b) binding site [chemical binding]; other site 768490003255 Putative water exit pathway; other site 768490003256 Binuclear center (heme o3/CuB) [ion binding]; other site 768490003257 K-pathway; other site 768490003258 Putative proton exit pathway; other site 768490003259 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 768490003260 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 768490003261 Acetyl-coenzyme A transporter 1; Region: Acatn; pfam13000 768490003262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490003263 putative substrate translocation pore; other site 768490003264 hypothetical protein; Provisional; Region: PRK11627 768490003265 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 768490003266 transcriptional regulator BolA; Provisional; Region: PRK11628 768490003267 trigger factor; Provisional; Region: tig; PRK01490 768490003268 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 768490003269 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 768490003270 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 768490003271 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 768490003272 oligomer interface [polypeptide binding]; other site 768490003273 active site residues [active] 768490003274 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 768490003275 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 768490003276 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768490003277 Walker A motif; other site 768490003278 ATP binding site [chemical binding]; other site 768490003279 Walker B motif; other site 768490003280 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 768490003281 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 768490003282 Found in ATP-dependent protease La (LON); Region: LON; smart00464 768490003283 Found in ATP-dependent protease La (LON); Region: LON; smart00464 768490003284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768490003285 Walker A motif; other site 768490003286 ATP binding site [chemical binding]; other site 768490003287 Walker B motif; other site 768490003288 arginine finger; other site 768490003289 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 768490003290 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 768490003291 IHF dimer interface [polypeptide binding]; other site 768490003292 IHF - DNA interface [nucleotide binding]; other site 768490003293 periplasmic folding chaperone; Provisional; Region: PRK10788 768490003294 SurA N-terminal domain; Region: SurA_N_3; cl07813 768490003295 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 768490003296 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 768490003297 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 768490003298 active site 768490003299 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 768490003300 Ligand Binding Site [chemical binding]; other site 768490003301 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 768490003302 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 768490003303 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 768490003304 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 768490003305 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768490003306 active site 768490003307 motif I; other site 768490003308 motif II; other site 768490003309 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 768490003310 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 768490003311 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 768490003312 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768490003313 catalytic residue [active] 768490003314 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768490003315 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768490003316 putative DNA binding site [nucleotide binding]; other site 768490003317 putative Zn2+ binding site [ion binding]; other site 768490003318 AsnC family; Region: AsnC_trans_reg; pfam01037 768490003319 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 768490003320 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768490003321 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768490003322 Walker A/P-loop; other site 768490003323 ATP binding site [chemical binding]; other site 768490003324 Q-loop/lid; other site 768490003325 ABC transporter signature motif; other site 768490003326 Walker B; other site 768490003327 D-loop; other site 768490003328 H-loop/switch region; other site 768490003329 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 768490003330 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768490003331 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 768490003332 Walker A/P-loop; other site 768490003333 ATP binding site [chemical binding]; other site 768490003334 Q-loop/lid; other site 768490003335 ABC transporter signature motif; other site 768490003336 Walker B; other site 768490003337 D-loop; other site 768490003338 H-loop/switch region; other site 768490003339 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 768490003340 Nitrogen regulatory protein P-II; Region: P-II; smart00938 768490003341 ammonium transporter; Provisional; Region: PRK10666 768490003342 acyl-CoA thioesterase II; Provisional; Region: PRK10526 768490003343 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 768490003344 active site 768490003345 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 768490003346 catalytic triad [active] 768490003347 dimer interface [polypeptide binding]; other site 768490003348 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 768490003349 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 768490003350 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 768490003351 DNA binding site [nucleotide binding] 768490003352 active site 768490003353 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 768490003354 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768490003355 active site 768490003356 DNA binding site [nucleotide binding] 768490003357 Int/Topo IB signature motif; other site 768490003358 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 768490003359 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768490003360 active site 768490003361 DNA binding site [nucleotide binding] 768490003362 Int/Topo IB signature motif; other site 768490003363 Helix-turn-helix domain; Region: HTH_36; pfam13730 768490003364 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 768490003365 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442 768490003366 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768490003367 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 768490003368 Right handed beta helix region; Region: Beta_helix; pfam13229 768490003369 gene expression modulator; Provisional; Region: PRK10945 768490003370 Hha toxicity attenuator; Provisional; Region: PRK10667 768490003371 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 768490003372 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 768490003373 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 768490003374 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768490003375 ABC-ATPase subunit interface; other site 768490003376 dimer interface [polypeptide binding]; other site 768490003377 putative PBP binding regions; other site 768490003378 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 768490003379 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 768490003380 metal binding site [ion binding]; metal-binding site 768490003381 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 768490003382 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 768490003383 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 768490003384 Protein export membrane protein; Region: SecD_SecF; cl14618 768490003385 Protein export membrane protein; Region: SecD_SecF; cl14618 768490003386 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 768490003387 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768490003388 HlyD family secretion protein; Region: HlyD_3; pfam13437 768490003389 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 768490003390 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768490003391 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 768490003392 DsrE/DsrF-like family; Region: DrsE; cl00672 768490003393 hypothetical protein; Provisional; Region: PRK11281 768490003394 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 768490003395 Mechanosensitive ion channel; Region: MS_channel; pfam00924 768490003396 Protein of unknown function (DUF2496); Region: DUF2496; cl11670 768490003397 Primosomal replication protein priB and priC; Region: priB_priC; pfam07445 768490003398 hypothetical protein; Provisional; Region: PRK10527 768490003399 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768490003400 active site 768490003401 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 768490003402 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768490003403 Walker A motif; other site 768490003404 ATP binding site [chemical binding]; other site 768490003405 Walker B motif; other site 768490003406 arginine finger; other site 768490003407 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 768490003408 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 768490003409 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 768490003410 hypothetical protein; Validated; Region: PRK00153 768490003411 recombination protein RecR; Reviewed; Region: recR; PRK00076 768490003412 RecR protein; Region: RecR; pfam02132 768490003413 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 768490003414 putative active site [active] 768490003415 putative metal-binding site [ion binding]; other site 768490003416 tetramer interface [polypeptide binding]; other site 768490003417 heat shock protein 90; Provisional; Region: PRK05218 768490003418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490003419 ATP binding site [chemical binding]; other site 768490003420 Mg2+ binding site [ion binding]; other site 768490003421 G-X-G motif; other site 768490003422 adenylate kinase; Reviewed; Region: adk; PRK00279 768490003423 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 768490003424 AMP-binding site [chemical binding]; other site 768490003425 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 768490003426 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 768490003427 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 768490003428 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 768490003429 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 768490003430 fructuronate transporter; Provisional; Region: PRK10034; cl15264 768490003431 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 768490003432 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 768490003433 ferrochelatase; Reviewed; Region: hemH; PRK00035 768490003434 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 768490003435 C-terminal domain interface [polypeptide binding]; other site 768490003436 active site 768490003437 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 768490003438 active site 768490003439 N-terminal domain interface [polypeptide binding]; other site 768490003440 inosine/guanosine kinase; Provisional; Region: PRK15074 768490003441 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768490003442 substrate binding site [chemical binding]; other site 768490003443 ATP binding site [chemical binding]; other site 768490003444 putative cation:proton antiport protein; Provisional; Region: PRK10669 768490003445 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 768490003446 TrkA-N domain; Region: TrkA_N; pfam02254 768490003447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490003448 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768490003449 putative substrate translocation pore; other site 768490003450 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 768490003451 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 768490003452 active site 768490003453 metal binding site [ion binding]; metal-binding site 768490003454 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 768490003455 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 768490003456 putative deacylase active site [active] 768490003457 TraB family; Region: TraB; cl12050 768490003458 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 768490003459 metal-binding site [ion binding] 768490003460 copper exporting ATPase; Provisional; Region: copA; PRK10671 768490003461 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 768490003462 metal-binding site [ion binding] 768490003463 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 768490003464 metal-binding site [ion binding] 768490003465 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768490003466 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768490003467 motif II; other site 768490003468 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 768490003469 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 768490003470 DNA binding residues [nucleotide binding] 768490003471 dimer interface [polypeptide binding]; other site 768490003472 copper binding site [ion binding]; other site 768490003473 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 768490003474 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 768490003475 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 768490003476 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 768490003477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490003478 S-adenosylmethionine binding site [chemical binding]; other site 768490003479 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 768490003480 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 768490003481 oxidoreductase; Provisional; Region: PRK08017 768490003482 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 768490003483 NADP binding site [chemical binding]; other site 768490003484 active site 768490003485 steroid binding site; other site 768490003486 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 768490003487 active site 768490003488 catalytic triad [active] 768490003489 oxyanion hole [active] 768490003490 switch loop; other site 768490003491 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 768490003492 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768490003493 Walker A/P-loop; other site 768490003494 ATP binding site [chemical binding]; other site 768490003495 Q-loop/lid; other site 768490003496 ABC transporter signature motif; other site 768490003497 Walker B; other site 768490003498 D-loop; other site 768490003499 H-loop/switch region; other site 768490003500 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 768490003501 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768490003502 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 768490003503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490003504 putative substrate translocation pore; other site 768490003505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490003506 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 768490003507 ATP-grasp domain; Region: ATP-grasp; pfam02222 768490003508 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 768490003509 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 768490003510 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 768490003511 putative active site [active] 768490003512 putative metal binding site [ion binding]; other site 768490003513 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 768490003514 substrate binding site [chemical binding]; other site 768490003515 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 768490003516 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 768490003517 active site 768490003518 HIGH motif; other site 768490003519 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 768490003520 KMSKS motif; other site 768490003521 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 768490003522 tRNA binding surface [nucleotide binding]; other site 768490003523 anticodon binding site; other site 768490003524 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768490003525 RNA binding surface [nucleotide binding]; other site 768490003526 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 768490003527 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 768490003528 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 768490003529 homodimer interface [polypeptide binding]; other site 768490003530 NADP binding site [chemical binding]; other site 768490003531 substrate binding site [chemical binding]; other site 768490003532 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 768490003533 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 768490003534 Amidohydrolase; Region: Amidohydro_2; pfam04909 768490003535 active site 768490003536 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768490003537 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768490003538 Fimbrial protein; Region: Fimbrial; cl01416 768490003539 Fimbrial protein; Region: Fimbrial; cl01416 768490003540 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 768490003541 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 768490003542 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 768490003543 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 768490003544 PapC N-terminal domain; Region: PapC_N; pfam13954 768490003545 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 768490003546 PapC C-terminal domain; Region: PapC_C; pfam13953 768490003547 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 768490003548 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 768490003549 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 768490003550 mannosyl binding site [chemical binding]; other site 768490003551 Fimbrial protein; Region: Fimbrial; pfam00419 768490003552 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 768490003553 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 768490003554 Active Sites [active] 768490003555 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 768490003556 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 768490003557 ParB-like nuclease domain; Region: ParB; smart00470 768490003558 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 768490003559 L-lactate permease; Region: Lactate_perm; cl00701 768490003560 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 768490003561 Cysteine-rich domain; Region: CCG; pfam02754 768490003562 Cysteine-rich domain; Region: CCG; pfam02754 768490003563 iron-sulfur cluster-binding protein; Region: TIGR00273 768490003564 HsdM N-terminal domain; Region: HsdM_N; pfam12161 768490003565 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 768490003566 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768490003567 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 768490003568 Uncharacterized conserved protein [Function unknown]; Region: COG1556 768490003569 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 768490003570 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490003571 active site 768490003572 phosphorylation site [posttranslational modification] 768490003573 intermolecular recognition site; other site 768490003574 dimerization interface [polypeptide binding]; other site 768490003575 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768490003576 Walker A motif; other site 768490003577 ATP binding site [chemical binding]; other site 768490003578 Walker B motif; other site 768490003579 arginine finger; other site 768490003580 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768490003581 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768490003582 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768490003583 phosphorylation site [posttranslational modification] 768490003584 dimer interface [polypeptide binding]; other site 768490003585 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490003586 ATP binding site [chemical binding]; other site 768490003587 Mg2+ binding site [ion binding]; other site 768490003588 G-X-G motif; other site 768490003589 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 768490003590 conserved cys residue [active] 768490003591 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768490003592 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490003593 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490003594 3-oxoacyl-acyl carrier protein synthase; Provisional; Region: PTZ00050 768490003595 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 768490003596 active site 768490003597 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 768490003598 acyl-CoA synthetase; Validated; Region: PRK05850 768490003599 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 768490003600 acyl-activating enzyme (AAE) consensus motif; other site 768490003601 active site 768490003602 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 768490003603 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 768490003604 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 768490003605 active site 768490003606 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 768490003607 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768490003608 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 768490003609 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768490003610 inhibitor-cofactor binding pocket; inhibition site 768490003611 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490003612 catalytic residue [active] 768490003613 Condensation domain; Region: Condensation; pfam00668 768490003614 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 768490003615 Arylesterase; Region: Arylesterase; pfam01731 768490003616 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768490003617 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 768490003618 catalytic loop [active] 768490003619 iron binding site [ion binding]; other site 768490003620 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 768490003621 FAD binding pocket [chemical binding]; other site 768490003622 conserved FAD binding motif [chemical binding]; other site 768490003623 phosphate binding motif [ion binding]; other site 768490003624 beta-alpha-beta structure motif; other site 768490003625 NAD binding pocket [chemical binding]; other site 768490003626 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 768490003627 Fatty acid desaturase; Region: FA_desaturase; pfam00487 768490003628 putative di-iron ligands [ion binding]; other site 768490003629 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 768490003630 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768490003631 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 768490003632 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 768490003633 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 768490003634 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 768490003635 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768490003636 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768490003637 active site 768490003638 catalytic tetrad [active] 768490003639 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490003640 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490003641 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 768490003642 putative effector binding pocket; other site 768490003643 putative dimerization interface [polypeptide binding]; other site 768490003644 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 768490003645 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768490003646 MASE1; Region: MASE1; cl17823 768490003647 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768490003648 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768490003649 metal binding site [ion binding]; metal-binding site 768490003650 active site 768490003651 I-site; other site 768490003652 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768490003653 DNA-binding site [nucleotide binding]; DNA binding site 768490003654 RNA-binding motif; other site 768490003655 The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6, and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348 768490003656 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768490003657 putative active site [active] 768490003658 putative metal binding site [ion binding]; other site 768490003659 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 768490003660 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768490003661 Walker A/P-loop; other site 768490003662 ATP binding site [chemical binding]; other site 768490003663 Q-loop/lid; other site 768490003664 ABC transporter signature motif; other site 768490003665 Walker B; other site 768490003666 D-loop; other site 768490003667 H-loop/switch region; other site 768490003668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490003669 dimer interface [polypeptide binding]; other site 768490003670 conserved gate region; other site 768490003671 putative PBP binding loops; other site 768490003672 ABC-ATPase subunit interface; other site 768490003673 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768490003674 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490003675 Coenzyme A binding pocket [chemical binding]; other site 768490003676 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 768490003677 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 768490003678 active site 768490003679 non-prolyl cis peptide bond; other site 768490003680 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 768490003681 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 768490003682 metal binding site [ion binding]; metal-binding site 768490003683 dimer interface [polypeptide binding]; other site 768490003684 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768490003685 DNA-binding site [nucleotide binding]; DNA binding site 768490003686 RNA-binding motif; other site 768490003687 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 768490003688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490003689 putative substrate translocation pore; other site 768490003690 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768490003691 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768490003692 chromosome condensation membrane protein; Provisional; Region: PRK14196 768490003693 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768490003694 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490003695 Coenzyme A binding pocket [chemical binding]; other site 768490003696 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 768490003697 MASE2 domain; Region: MASE2; pfam05230 768490003698 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768490003699 metal binding site [ion binding]; metal-binding site 768490003700 active site 768490003701 I-site; other site 768490003702 twin arginine translocase protein A; Validated; Region: tatE; PRK01614 768490003703 lipoyl synthase; Provisional; Region: PRK05481 768490003704 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768490003705 FeS/SAM binding site; other site 768490003706 lipoate-protein ligase B; Provisional; Region: PRK14342 768490003707 hypothetical protein; Provisional; Region: PRK04998 768490003708 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 768490003709 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 768490003710 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 768490003711 rare lipoprotein A; Provisional; Region: PRK10672 768490003712 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 768490003713 Sporulation related domain; Region: SPOR; cl10051 768490003714 cell wall shape-determining protein; Provisional; Region: PRK10794 768490003715 penicillin-binding protein 2; Provisional; Region: PRK10795 768490003716 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 768490003717 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 768490003718 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 768490003719 Oligomerisation domain; Region: Oligomerisation; cl00519 768490003720 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 768490003721 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 768490003722 active site 768490003723 (T/H)XGH motif; other site 768490003724 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 768490003725 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 768490003726 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 768490003727 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 768490003728 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 768490003729 HIGH motif; other site 768490003730 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 768490003731 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768490003732 active site 768490003733 KMSKS motif; other site 768490003734 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 768490003735 tRNA binding surface [nucleotide binding]; other site 768490003736 hypothetical protein; Provisional; Region: PRK11032 768490003737 Predicted integral membrane metal-binding protein (DUF2296); Region: DUF2296; pfam10058 768490003738 azoreductase; Reviewed; Region: PRK00170 768490003739 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768490003740 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 768490003741 active site 768490003742 tetramer interface [polypeptide binding]; other site 768490003743 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 768490003744 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 768490003745 Walker A/P-loop; other site 768490003746 ATP binding site [chemical binding]; other site 768490003747 Q-loop/lid; other site 768490003748 ABC transporter signature motif; other site 768490003749 Walker B; other site 768490003750 D-loop; other site 768490003751 H-loop/switch region; other site 768490003752 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768490003753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490003754 dimer interface [polypeptide binding]; other site 768490003755 conserved gate region; other site 768490003756 putative PBP binding loops; other site 768490003757 ABC-ATPase subunit interface; other site 768490003758 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768490003759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490003760 dimer interface [polypeptide binding]; other site 768490003761 conserved gate region; other site 768490003762 putative PBP binding loops; other site 768490003763 ABC-ATPase subunit interface; other site 768490003764 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 768490003765 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768490003766 substrate binding pocket [chemical binding]; other site 768490003767 membrane-bound complex binding site; other site 768490003768 hinge residues; other site 768490003769 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 768490003770 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 768490003771 putative active site [active] 768490003772 catalytic triad [active] 768490003773 putative dimer interface [polypeptide binding]; other site 768490003774 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 768490003775 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 768490003776 Transporter associated domain; Region: CorC_HlyC; smart01091 768490003777 metal-binding heat shock protein; Provisional; Region: PRK00016 768490003778 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 768490003779 PhoH-like protein; Region: PhoH; pfam02562 768490003780 hypothetical protein; Provisional; Region: PRK10220 768490003781 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 768490003782 PhnA protein; Region: PhnA; pfam03831 768490003783 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 768490003784 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 768490003785 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768490003786 FeS/SAM binding site; other site 768490003787 TRAM domain; Region: TRAM; pfam01938 768490003788 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 768490003789 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 768490003790 asparagine synthetase B; Provisional; Region: asnB; PRK09431 768490003791 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 768490003792 active site 768490003793 dimer interface [polypeptide binding]; other site 768490003794 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 768490003795 Ligand Binding Site [chemical binding]; other site 768490003796 Molecular Tunnel; other site 768490003797 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 768490003798 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 768490003799 putative active site [active] 768490003800 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 768490003801 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 768490003802 UMP phosphatase; Provisional; Region: PRK10444 768490003803 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768490003804 active site 768490003805 motif I; other site 768490003806 motif II; other site 768490003807 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768490003808 MarR family; Region: MarR; pfam01047 768490003809 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 768490003810 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768490003811 nucleotide binding site [chemical binding]; other site 768490003812 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 768490003813 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 768490003814 active site 768490003815 dimer interface [polypeptide binding]; other site 768490003816 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 768490003817 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 768490003818 active site 768490003819 trimer interface [polypeptide binding]; other site 768490003820 allosteric site; other site 768490003821 active site lid [active] 768490003822 hexamer (dimer of trimers) interface [polypeptide binding]; other site 768490003823 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 768490003824 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768490003825 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768490003826 active site turn [active] 768490003827 phosphorylation site [posttranslational modification] 768490003828 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 768490003829 HPr interaction site; other site 768490003830 glycerol kinase (GK) interaction site [polypeptide binding]; other site 768490003831 active site 768490003832 phosphorylation site [posttranslational modification] 768490003833 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 768490003834 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768490003835 active site 768490003836 HIGH motif; other site 768490003837 nucleotide binding site [chemical binding]; other site 768490003838 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 768490003839 KMSKS motif; other site 768490003840 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 768490003841 outer membrane porin, OprD family; Region: OprD; pfam03573 768490003842 YbfN-like lipoprotein; Region: YbfN; pfam13982 768490003843 Putative carbohydrate binding domain; Region: CHB_HEX; smart01081 768490003844 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 768490003845 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 768490003846 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a...; Region: GH20_Sm-chitobiase-like; cd06569 768490003847 active site 768490003848 C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847 768490003849 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490003850 sugar efflux transporter; Region: 2A0120; TIGR00899 768490003851 putative substrate translocation pore; other site 768490003852 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 768490003853 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 768490003854 NAD binding site [chemical binding]; other site 768490003855 homodimer interface [polypeptide binding]; other site 768490003856 active site 768490003857 substrate binding site [chemical binding]; other site 768490003858 TcdB toxin N-terminal helical domain; Region: TcdB_N; pfam12918 768490003859 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 768490003860 ferric uptake regulator; Provisional; Region: fur; PRK09462 768490003861 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 768490003862 metal binding site 2 [ion binding]; metal-binding site 768490003863 putative DNA binding helix; other site 768490003864 metal binding site 1 [ion binding]; metal-binding site 768490003865 dimer interface [polypeptide binding]; other site 768490003866 structural Zn2+ binding site [ion binding]; other site 768490003867 flavodoxin FldA; Validated; Region: PRK09267 768490003868 LexA regulated protein; Provisional; Region: PRK11675 768490003869 acyl-CoA esterase; Provisional; Region: PRK10673 768490003870 PGAP1-like protein; Region: PGAP1; pfam07819 768490003871 replication initiation regulator SeqA; Provisional; Region: PRK11187 768490003872 phosphoglucomutase; Validated; Region: PRK07564 768490003873 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 768490003874 active site 768490003875 substrate binding site [chemical binding]; other site 768490003876 metal binding site [ion binding]; metal-binding site 768490003877 Predicted transcriptional regulators [Transcription]; Region: COG1695 768490003878 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 768490003879 Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977 768490003880 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 768490003881 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490003882 active site 768490003883 phosphorylation site [posttranslational modification] 768490003884 intermolecular recognition site; other site 768490003885 dimerization interface [polypeptide binding]; other site 768490003886 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768490003887 DNA binding site [nucleotide binding] 768490003888 sensor protein KdpD; Provisional; Region: PRK10490 768490003889 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 768490003890 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 768490003891 Ligand Binding Site [chemical binding]; other site 768490003892 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 768490003893 GAF domain; Region: GAF_3; pfam13492 768490003894 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768490003895 dimer interface [polypeptide binding]; other site 768490003896 phosphorylation site [posttranslational modification] 768490003897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490003898 ATP binding site [chemical binding]; other site 768490003899 Mg2+ binding site [ion binding]; other site 768490003900 G-X-G motif; other site 768490003901 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 768490003902 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 768490003903 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768490003904 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 768490003905 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 768490003906 Protein of unknown function (DUF523); Region: DUF523; pfam04463 768490003907 Uncharacterized conserved protein [Function unknown]; Region: COG3272 768490003908 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 768490003909 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 768490003910 DNA photolyase; Region: DNA_photolyase; pfam00875 768490003911 cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776 768490003912 Uncharacterized conserved protein [Function unknown]; Region: COG0327 768490003913 metal-binding protein; Provisional; Region: PRK10799 768490003914 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 768490003915 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 768490003916 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 768490003917 LamB/YcsF family protein; Provisional; Region: PRK05406 768490003918 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 768490003919 putative substrate binding pocket [chemical binding]; other site 768490003920 AC domain interface; other site 768490003921 catalytic triad [active] 768490003922 AB domain interface; other site 768490003923 interchain disulfide; other site 768490003924 endonuclease VIII; Provisional; Region: PRK10445 768490003925 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 768490003926 DNA binding site [nucleotide binding] 768490003927 catalytic residue [active] 768490003928 H2TH interface [polypeptide binding]; other site 768490003929 putative catalytic residues [active] 768490003930 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 768490003931 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 768490003932 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 768490003933 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 768490003934 dimer interface [polypeptide binding]; other site 768490003935 active site 768490003936 citrylCoA binding site [chemical binding]; other site 768490003937 NADH binding [chemical binding]; other site 768490003938 cationic pore residues; other site 768490003939 oxalacetate/citrate binding site [chemical binding]; other site 768490003940 coenzyme A binding site [chemical binding]; other site 768490003941 catalytic triad [active] 768490003942 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 768490003943 Iron-sulfur protein interface; other site 768490003944 proximal quinone binding site [chemical binding]; other site 768490003945 SdhD (CybS) interface [polypeptide binding]; other site 768490003946 proximal heme binding site [chemical binding]; other site 768490003947 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 768490003948 SdhC subunit interface [polypeptide binding]; other site 768490003949 proximal heme binding site [chemical binding]; other site 768490003950 cardiolipin binding site; other site 768490003951 Iron-sulfur protein interface; other site 768490003952 proximal quinone binding site [chemical binding]; other site 768490003953 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 768490003954 L-aspartate oxidase; Provisional; Region: PRK06175 768490003955 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 768490003956 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 768490003957 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 768490003958 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 768490003959 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 768490003960 TPP-binding site [chemical binding]; other site 768490003961 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 768490003962 dimer interface [polypeptide binding]; other site 768490003963 PYR/PP interface [polypeptide binding]; other site 768490003964 TPP binding site [chemical binding]; other site 768490003965 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 768490003966 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768490003967 E3 interaction surface; other site 768490003968 lipoyl attachment site [posttranslational modification]; other site 768490003969 e3 binding domain; Region: E3_binding; pfam02817 768490003970 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 768490003971 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 768490003972 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 768490003973 CoA-ligase; Region: Ligase_CoA; pfam00549 768490003974 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 768490003975 CoA binding domain; Region: CoA_binding; smart00881 768490003976 CoA-ligase; Region: Ligase_CoA; pfam00549 768490003977 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 768490003978 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 768490003979 active site 768490003980 metal binding site [ion binding]; metal-binding site 768490003981 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 768490003982 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 768490003983 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 768490003984 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 768490003985 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 768490003986 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 768490003987 hypothetical protein; Provisional; Region: PRK10588 768490003988 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 768490003989 active site 768490003990 colicin uptake protein TolQ; Provisional; Region: PRK10801 768490003991 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 768490003992 colicin uptake protein TolR; Provisional; Region: PRK11024 768490003993 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 768490003994 TolA C-terminal; Region: TolA; pfam06519 768490003995 translocation protein TolB; Provisional; Region: tolB; PRK03629 768490003996 TolB amino-terminal domain; Region: TolB_N; pfam04052 768490003997 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 768490003998 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 768490003999 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 768490004000 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 768490004001 Serglycin; Region: Serglycin; pfam04360 768490004002 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 768490004003 ligand binding site [chemical binding]; other site 768490004004 tol-pal system protein YbgF; Provisional; Region: PRK10803 768490004005 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768490004006 binding surface 768490004007 TPR motif; other site 768490004008 quinolinate synthetase; Provisional; Region: PRK09375 768490004009 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 768490004010 zinc transporter ZitB; Provisional; Region: PRK03557 768490004011 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768490004012 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768490004013 substrate binding pocket [chemical binding]; other site 768490004014 membrane-bound complex binding site; other site 768490004015 hinge residues; other site 768490004016 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768490004017 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768490004018 substrate binding pocket [chemical binding]; other site 768490004019 membrane-bound complex binding site; other site 768490004020 hinge residues; other site 768490004021 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768490004022 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768490004023 dimer interface [polypeptide binding]; other site 768490004024 phosphorylation site [posttranslational modification] 768490004025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490004026 ATP binding site [chemical binding]; other site 768490004027 Mg2+ binding site [ion binding]; other site 768490004028 G-X-G motif; other site 768490004029 Response regulator receiver domain; Region: Response_reg; pfam00072 768490004030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490004031 active site 768490004032 phosphorylation site [posttranslational modification] 768490004033 intermolecular recognition site; other site 768490004034 dimerization interface [polypeptide binding]; other site 768490004035 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 768490004036 putative binding surface; other site 768490004037 active site 768490004038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490004039 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768490004040 active site 768490004041 phosphorylation site [posttranslational modification] 768490004042 intermolecular recognition site; other site 768490004043 dimerization interface [polypeptide binding]; other site 768490004044 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768490004045 DNA binding residues [nucleotide binding] 768490004046 dimerization interface [polypeptide binding]; other site 768490004047 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 768490004048 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 768490004049 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768490004050 catalytic core [active] 768490004051 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768490004052 psiF repeat; Region: PsiF_repeat; pfam07769 768490004053 psiF repeat; Region: PsiF_repeat; pfam07769 768490004054 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 768490004055 active site 768490004056 catalytic residues [active] 768490004057 galactokinase; Provisional; Region: PRK05101 768490004058 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 768490004059 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 768490004060 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 768490004061 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 768490004062 dimer interface [polypeptide binding]; other site 768490004063 active site 768490004064 CAAX protease self-immunity; Region: Abi; pfam02517 768490004065 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 768490004066 Isochorismatase family; Region: Isochorismatase; pfam00857 768490004067 catalytic triad [active] 768490004068 conserved cis-peptide bond; other site 768490004069 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 768490004070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768490004071 Walker A/P-loop; other site 768490004072 ATP binding site [chemical binding]; other site 768490004073 Q-loop/lid; other site 768490004074 ABC transporter signature motif; other site 768490004075 Walker B; other site 768490004076 D-loop; other site 768490004077 H-loop/switch region; other site 768490004078 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768490004079 Walker A/P-loop; other site 768490004080 ATP binding site [chemical binding]; other site 768490004081 Q-loop/lid; other site 768490004082 ABC transporter signature motif; other site 768490004083 Walker B; other site 768490004084 D-loop; other site 768490004085 H-loop/switch region; other site 768490004086 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 768490004087 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 768490004088 molybdenum-pterin binding domain; Region: Mop; TIGR00638 768490004089 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 768490004090 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 768490004091 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 768490004092 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 768490004093 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 768490004094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490004095 dimer interface [polypeptide binding]; other site 768490004096 conserved gate region; other site 768490004097 putative PBP binding loops; other site 768490004098 ABC-ATPase subunit interface; other site 768490004099 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 768490004100 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768490004101 Walker A/P-loop; other site 768490004102 ATP binding site [chemical binding]; other site 768490004103 Q-loop/lid; other site 768490004104 ABC transporter signature motif; other site 768490004105 Walker B; other site 768490004106 D-loop; other site 768490004107 H-loop/switch region; other site 768490004108 molybdenum-pterin binding domain; Region: Mop; TIGR00638 768490004109 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 768490004110 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768490004111 active site 768490004112 motif I; other site 768490004113 motif II; other site 768490004114 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768490004115 6-phosphogluconolactonase; Provisional; Region: PRK11028 768490004116 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 768490004117 substrate binding site [chemical binding]; other site 768490004118 Uncharacterized conserved protein [Function unknown]; Region: COG3339 768490004119 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 768490004120 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768490004121 inhibitor-cofactor binding pocket; inhibition site 768490004122 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490004123 catalytic residue [active] 768490004124 biotin synthase; Provisional; Region: PRK15108 768490004125 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768490004126 FeS/SAM binding site; other site 768490004127 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 768490004128 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 768490004129 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 768490004130 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768490004131 catalytic residue [active] 768490004132 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 768490004133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490004134 S-adenosylmethionine binding site [chemical binding]; other site 768490004135 AAA domain; Region: AAA_26; pfam13500 768490004136 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 768490004137 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 768490004138 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 768490004139 Walker A/P-loop; other site 768490004140 ATP binding site [chemical binding]; other site 768490004141 Q-loop/lid; other site 768490004142 ABC transporter signature motif; other site 768490004143 Walker B; other site 768490004144 D-loop; other site 768490004145 H-loop/switch region; other site 768490004146 excinuclease ABC subunit B; Provisional; Region: PRK05298 768490004147 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768490004148 ATP binding site [chemical binding]; other site 768490004149 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768490004150 nucleotide binding region [chemical binding]; other site 768490004151 ATP-binding site [chemical binding]; other site 768490004152 Ultra-violet resistance protein B; Region: UvrB; pfam12344 768490004153 UvrB/uvrC motif; Region: UVR; pfam02151 768490004154 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 768490004155 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 768490004156 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 768490004157 phosphate binding site [ion binding]; other site 768490004158 putative substrate binding pocket [chemical binding]; other site 768490004159 dimer interface [polypeptide binding]; other site 768490004160 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 768490004161 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768490004162 FeS/SAM binding site; other site 768490004163 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 768490004164 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 768490004165 MPT binding site; other site 768490004166 trimer interface [polypeptide binding]; other site 768490004167 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 768490004168 trimer interface [polypeptide binding]; other site 768490004169 dimer interface [polypeptide binding]; other site 768490004170 putative active site [active] 768490004171 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 768490004172 MoaE interaction surface [polypeptide binding]; other site 768490004173 MoeB interaction surface [polypeptide binding]; other site 768490004174 thiocarboxylated glycine; other site 768490004175 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 768490004176 MoaE homodimer interface [polypeptide binding]; other site 768490004177 MoaD interaction [polypeptide binding]; other site 768490004178 active site residues [active] 768490004179 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 768490004180 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 768490004181 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 768490004182 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 768490004183 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 768490004184 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 768490004185 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 768490004186 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 768490004187 Walker A/P-loop; other site 768490004188 ATP binding site [chemical binding]; other site 768490004189 Q-loop/lid; other site 768490004190 ABC transporter signature motif; other site 768490004191 Walker B; other site 768490004192 D-loop; other site 768490004193 H-loop/switch region; other site 768490004194 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 768490004195 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 768490004196 Walker A/P-loop; other site 768490004197 ATP binding site [chemical binding]; other site 768490004198 Q-loop/lid; other site 768490004199 ABC transporter signature motif; other site 768490004200 Walker B; other site 768490004201 D-loop; other site 768490004202 H-loop/switch region; other site 768490004203 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 768490004204 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768490004205 HlyD family secretion protein; Region: HlyD_3; pfam13437 768490004206 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 768490004207 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768490004208 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 768490004209 helicase 45; Provisional; Region: PTZ00424 768490004210 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 768490004211 ATP binding site [chemical binding]; other site 768490004212 Mg++ binding site [ion binding]; other site 768490004213 motif III; other site 768490004214 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768490004215 nucleotide binding region [chemical binding]; other site 768490004216 ATP-binding site [chemical binding]; other site 768490004217 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 768490004218 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 768490004219 dimerization interface [polypeptide binding]; other site 768490004220 NAD binding site [chemical binding]; other site 768490004221 ligand binding site [chemical binding]; other site 768490004222 catalytic site [active] 768490004223 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 768490004224 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 768490004225 FMN binding site [chemical binding]; other site 768490004226 active site 768490004227 catalytic residues [active] 768490004228 substrate binding site [chemical binding]; other site 768490004229 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 768490004230 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490004231 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490004232 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768490004233 dimerization interface [polypeptide binding]; other site 768490004234 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 768490004235 HD domain; Region: HD_4; pfam13328 768490004236 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 768490004237 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 768490004238 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 768490004239 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768490004240 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490004241 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 768490004242 dimerization interface [polypeptide binding]; other site 768490004243 substrate binding pocket [chemical binding]; other site 768490004244 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 768490004245 L-asparagine permease; Provisional; Region: PRK15049 768490004246 Predicted membrane protein [Function unknown]; Region: COG4125 768490004247 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 768490004248 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 768490004249 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490004250 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490004251 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768490004252 dimerization interface [polypeptide binding]; other site 768490004253 LysE type translocator; Region: LysE; cl00565 768490004254 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 768490004255 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 768490004256 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 768490004257 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 768490004258 conserved cys residue [active] 768490004259 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 768490004260 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 768490004261 conserved cys residue [active] 768490004262 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490004263 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490004264 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 768490004265 NAD binding site [chemical binding]; other site 768490004266 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 768490004267 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 768490004268 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490004269 Coenzyme A binding pocket [chemical binding]; other site 768490004270 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 768490004271 dimer interface [polypeptide binding]; other site 768490004272 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768490004273 Protein of unknown function (DUF808); Region: DUF808; pfam05661 768490004274 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 768490004275 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490004276 Coenzyme A binding pocket [chemical binding]; other site 768490004277 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768490004278 EamA-like transporter family; Region: EamA; pfam00892 768490004279 EamA-like transporter family; Region: EamA; pfam00892 768490004280 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490004281 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490004282 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768490004283 dimerization interface [polypeptide binding]; other site 768490004284 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 768490004285 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 768490004286 DNA binding residues [nucleotide binding] 768490004287 putative dimer interface [polypeptide binding]; other site 768490004288 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 768490004289 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 768490004290 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 768490004291 lipoprotein, YaeC family; Region: TIGR00363 768490004292 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 768490004293 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490004294 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768490004295 Coenzyme A binding pocket [chemical binding]; other site 768490004296 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 768490004297 putative trimer interface [polypeptide binding]; other site 768490004298 putative active site [active] 768490004299 putative substrate binding site [chemical binding]; other site 768490004300 putative CoA binding site [chemical binding]; other site 768490004301 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 768490004302 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 768490004303 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 768490004304 NAD(P) binding site [chemical binding]; other site 768490004305 catalytic residues [active] 768490004306 D-lactate dehydrogenase; Provisional; Region: PRK11183 768490004307 FAD binding domain; Region: FAD_binding_4; pfam01565 768490004308 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 768490004309 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 768490004310 active site 768490004311 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 768490004312 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 768490004313 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 768490004314 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 768490004315 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 768490004316 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768490004317 substrate binding pocket [chemical binding]; other site 768490004318 membrane-bound complex binding site; other site 768490004319 hinge residues; other site 768490004320 putative aminotransferase; Provisional; Region: PRK12414 768490004321 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768490004322 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490004323 homodimer interface [polypeptide binding]; other site 768490004324 catalytic residue [active] 768490004325 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768490004326 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490004327 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 768490004328 dimerization interface [polypeptide binding]; other site 768490004329 substrate binding pocket [chemical binding]; other site 768490004330 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 768490004331 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 768490004332 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 768490004333 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 768490004334 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768490004335 DNA-binding site [nucleotide binding]; DNA binding site 768490004336 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 768490004337 Uncharacterized protein conserved in archaea (DUF2099); Region: DUF2099; cl01645 768490004338 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 768490004339 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 768490004340 putative ligand binding residues [chemical binding]; other site 768490004341 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 768490004342 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768490004343 ABC-ATPase subunit interface; other site 768490004344 dimer interface [polypeptide binding]; other site 768490004345 putative PBP binding regions; other site 768490004346 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 768490004347 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768490004348 Walker A/P-loop; other site 768490004349 ATP binding site [chemical binding]; other site 768490004350 Q-loop/lid; other site 768490004351 ABC transporter signature motif; other site 768490004352 Walker B; other site 768490004353 D-loop; other site 768490004354 H-loop/switch region; other site 768490004355 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 768490004356 molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537 768490004357 ParA-like protein; Provisional; Region: PHA02518 768490004358 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 768490004359 P-loop; other site 768490004360 Magnesium ion binding site [ion binding]; other site 768490004361 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 768490004362 active site 768490004363 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490004364 Coenzyme A binding pocket [chemical binding]; other site 768490004365 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490004366 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490004367 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 768490004368 putative effector binding pocket; other site 768490004369 putative dimerization interface [polypeptide binding]; other site 768490004370 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768490004371 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 768490004372 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 768490004373 putative N- and C-terminal domain interface [polypeptide binding]; other site 768490004374 putative active site [active] 768490004375 putative MgATP binding site [chemical binding]; other site 768490004376 catalytic site [active] 768490004377 metal binding site [ion binding]; metal-binding site 768490004378 putative carbohydrate binding site [chemical binding]; other site 768490004379 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 768490004380 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 768490004381 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768490004382 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490004383 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768490004384 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490004385 Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718 768490004386 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 768490004387 ATP binding site [chemical binding]; other site 768490004388 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 768490004389 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 768490004390 active site 768490004391 Na/Ca binding site [ion binding]; other site 768490004392 catalytic site [active] 768490004393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4380 768490004394 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 768490004395 Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462 768490004396 diaminopimelate epimerase; Provisional; Region: PRK13577 768490004397 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 768490004398 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 768490004399 putative transposase OrfB; Reviewed; Region: PHA02517 768490004400 Integrase core domain; Region: rve; pfam00665 768490004401 Integrase core domain; Region: rve_3; pfam13683 768490004402 Homeodomain-like domain; Region: HTH_23; cl17451 768490004403 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 768490004404 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 768490004405 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768490004406 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768490004407 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 768490004408 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 768490004409 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490004410 dimer interface [polypeptide binding]; other site 768490004411 conserved gate region; other site 768490004412 putative PBP binding loops; other site 768490004413 ABC-ATPase subunit interface; other site 768490004414 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 768490004415 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 768490004416 Walker A/P-loop; other site 768490004417 ATP binding site [chemical binding]; other site 768490004418 Q-loop/lid; other site 768490004419 ABC transporter signature motif; other site 768490004420 Walker B; other site 768490004421 D-loop; other site 768490004422 H-loop/switch region; other site 768490004423 NIL domain; Region: NIL; pfam09383 768490004424 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768490004425 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490004426 Coenzyme A binding pocket [chemical binding]; other site 768490004427 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490004428 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490004429 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 768490004430 putative effector binding pocket; other site 768490004431 putative dimerization interface [polypeptide binding]; other site 768490004432 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 768490004433 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 768490004434 NADP binding site [chemical binding]; other site 768490004435 dimer interface [polypeptide binding]; other site 768490004436 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 768490004437 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 768490004438 Isochorismatase family; Region: Isochorismatase; pfam00857 768490004439 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 768490004440 catalytic triad [active] 768490004441 conserved cis-peptide bond; other site 768490004442 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768490004443 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 768490004444 NAD(P) binding site [chemical binding]; other site 768490004445 active site 768490004446 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 768490004447 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490004448 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 768490004449 dimerization interface [polypeptide binding]; other site 768490004450 substrate binding pocket [chemical binding]; other site 768490004451 Predicted transcriptional regulator [Transcription]; Region: COG2378 768490004452 HTH domain; Region: HTH_11; pfam08279 768490004453 WYL domain; Region: WYL; pfam13280 768490004454 D-galactonate transporter; Region: 2A0114; TIGR00893 768490004455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490004456 putative substrate translocation pore; other site 768490004457 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768490004458 DNA-binding site [nucleotide binding]; DNA binding site 768490004459 Transcriptional regulators [Transcription]; Region: GntR; COG1802 768490004460 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 768490004461 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 768490004462 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 768490004463 putative NAD(P) binding site [chemical binding]; other site 768490004464 catalytic Zn binding site [ion binding]; other site 768490004465 structural Zn binding site [ion binding]; other site 768490004466 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 768490004467 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 768490004468 Walker A/P-loop; other site 768490004469 ATP binding site [chemical binding]; other site 768490004470 Q-loop/lid; other site 768490004471 ABC transporter signature motif; other site 768490004472 Walker B; other site 768490004473 D-loop; other site 768490004474 H-loop/switch region; other site 768490004475 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 768490004476 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 768490004477 substrate binding pocket [chemical binding]; other site 768490004478 membrane-bound complex binding site; other site 768490004479 hinge residues; other site 768490004480 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 768490004481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490004482 dimer interface [polypeptide binding]; other site 768490004483 conserved gate region; other site 768490004484 putative PBP binding loops; other site 768490004485 ABC-ATPase subunit interface; other site 768490004486 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 768490004487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490004488 dimer interface [polypeptide binding]; other site 768490004489 conserved gate region; other site 768490004490 putative PBP binding loops; other site 768490004491 ABC-ATPase subunit interface; other site 768490004492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 768490004493 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 768490004494 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 768490004495 allophanate hydrolase; Provisional; Region: PRK08186 768490004496 Amidase; Region: Amidase; cl11426 768490004497 urea carboxylase; Region: urea_carbox; TIGR02712 768490004498 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 768490004499 ATP-grasp domain; Region: ATP-grasp_4; cl17255 768490004500 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 768490004501 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 768490004502 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 768490004503 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 768490004504 carboxyltransferase (CT) interaction site; other site 768490004505 biotinylation site [posttranslational modification]; other site 768490004506 Transcriptional regulators [Transcription]; Region: GntR; COG1802 768490004507 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768490004508 DNA-binding site [nucleotide binding]; DNA binding site 768490004509 FCD domain; Region: FCD; pfam07729 768490004510 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 768490004511 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 768490004512 putative ligand binding site [chemical binding]; other site 768490004513 HEAT repeats; Region: HEAT_2; pfam13646 768490004514 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 768490004515 TM-ABC transporter signature motif; other site 768490004516 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 768490004517 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 768490004518 TM-ABC transporter signature motif; other site 768490004519 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 768490004520 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 768490004521 Walker A/P-loop; other site 768490004522 ATP binding site [chemical binding]; other site 768490004523 Q-loop/lid; other site 768490004524 ABC transporter signature motif; other site 768490004525 Walker B; other site 768490004526 D-loop; other site 768490004527 H-loop/switch region; other site 768490004528 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 768490004529 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 768490004530 Walker A/P-loop; other site 768490004531 ATP binding site [chemical binding]; other site 768490004532 Q-loop/lid; other site 768490004533 ABC transporter signature motif; other site 768490004534 Walker B; other site 768490004535 D-loop; other site 768490004536 H-loop/switch region; other site 768490004537 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 768490004538 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 768490004539 Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933 768490004540 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 768490004541 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 768490004542 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768490004543 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768490004544 hypothetical protein; Provisional; Region: PRK06185 768490004545 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 768490004546 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 768490004547 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490004548 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768490004549 dimerization interface [polypeptide binding]; other site 768490004550 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 768490004551 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 768490004552 active site residue [active] 768490004553 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 768490004554 active site residue [active] 768490004555 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 768490004556 nudix motif; other site 768490004557 Uncharacterized conserved protein [Function unknown]; Region: COG1683 768490004558 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768490004559 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 768490004560 NAD(P) binding site [chemical binding]; other site 768490004561 active site 768490004562 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 768490004563 Helix-turn-helix domain; Region: HTH_18; pfam12833 768490004564 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768490004565 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768490004566 DNA-binding site [nucleotide binding]; DNA binding site 768490004567 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768490004568 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490004569 homodimer interface [polypeptide binding]; other site 768490004570 catalytic residue [active] 768490004571 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 768490004572 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 768490004573 putative C-terminal domain interface [polypeptide binding]; other site 768490004574 putative GSH binding site (G-site) [chemical binding]; other site 768490004575 putative dimer interface [polypeptide binding]; other site 768490004576 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 768490004577 putative N-terminal domain interface [polypeptide binding]; other site 768490004578 putative dimer interface [polypeptide binding]; other site 768490004579 putative substrate binding pocket (H-site) [chemical binding]; other site 768490004580 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768490004581 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768490004582 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 768490004583 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 768490004584 Isochorismatase family; Region: Isochorismatase; pfam00857 768490004585 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 768490004586 catalytic triad [active] 768490004587 dimer interface [polypeptide binding]; other site 768490004588 conserved cis-peptide bond; other site 768490004589 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490004590 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490004591 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768490004592 dimerization interface [polypeptide binding]; other site 768490004593 Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764 768490004594 Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509 768490004595 Fatty acid desaturase; Region: FA_desaturase; pfam00487 768490004596 putative di-iron ligands [ion binding]; other site 768490004597 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 768490004598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490004599 dimer interface [polypeptide binding]; other site 768490004600 conserved gate region; other site 768490004601 ABC-ATPase subunit interface; other site 768490004602 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 768490004603 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 768490004604 Walker A/P-loop; other site 768490004605 ATP binding site [chemical binding]; other site 768490004606 Q-loop/lid; other site 768490004607 ABC transporter signature motif; other site 768490004608 Walker B; other site 768490004609 D-loop; other site 768490004610 H-loop/switch region; other site 768490004611 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 768490004612 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490004613 putative PBP binding loops; other site 768490004614 dimer interface [polypeptide binding]; other site 768490004615 ABC-ATPase subunit interface; other site 768490004616 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 768490004617 short chain dehydrogenase; Provisional; Region: PRK07041 768490004618 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768490004619 NAD(P) binding site [chemical binding]; other site 768490004620 active site 768490004621 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490004622 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490004623 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768490004624 putative effector binding pocket; other site 768490004625 dimerization interface [polypeptide binding]; other site 768490004626 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 768490004627 EamA-like transporter family; Region: EamA; pfam00892 768490004628 EamA-like transporter family; Region: EamA; pfam00892 768490004629 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 768490004630 Predicted transcriptional regulator [Transcription]; Region: COG2345 768490004631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490004632 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768490004633 putative substrate translocation pore; other site 768490004634 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768490004635 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768490004636 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490004637 AzlC protein; Region: AzlC; cl00570 768490004638 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 768490004639 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768490004640 non-specific DNA binding site [nucleotide binding]; other site 768490004641 salt bridge; other site 768490004642 sequence-specific DNA binding site [nucleotide binding]; other site 768490004643 putative acetyltransferase; Provisional; Region: PRK03624 768490004644 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490004645 Coenzyme A binding pocket [chemical binding]; other site 768490004646 Predicted secreted acid phosphatase [General function prediction only]; Region: COG2503 768490004647 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490004648 Coenzyme A binding pocket [chemical binding]; other site 768490004649 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 768490004650 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 768490004651 trimer interface [polypeptide binding]; other site 768490004652 eyelet of channel; other site 768490004653 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 768490004654 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 768490004655 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 768490004656 DEAD_2; Region: DEAD_2; pfam06733 768490004657 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 768490004658 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768490004659 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768490004660 putative DNA binding site [nucleotide binding]; other site 768490004661 putative Zn2+ binding site [ion binding]; other site 768490004662 AsnC family; Region: AsnC_trans_reg; pfam01037 768490004663 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768490004664 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 768490004665 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490004666 putative substrate translocation pore; other site 768490004667 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490004668 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490004669 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 768490004670 putative effector binding pocket; other site 768490004671 putative dimerization interface [polypeptide binding]; other site 768490004672 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 768490004673 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768490004674 salt bridge; other site 768490004675 non-specific DNA binding site [nucleotide binding]; other site 768490004676 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768490004677 sequence-specific DNA binding site [nucleotide binding]; other site 768490004678 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 768490004679 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 768490004680 glycosyl transferase family protein; Provisional; Region: PRK08136 768490004681 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 768490004682 Peptidase M3-like family, a zincin metallopeptidase, includes M3 and M32 families; Region: M3_like; cd06258 768490004683 active site 768490004684 Zn binding site [ion binding]; other site 768490004685 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 768490004686 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 768490004687 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 768490004688 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490004689 S-adenosylmethionine binding site [chemical binding]; other site 768490004690 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 768490004691 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 768490004692 Walker A/P-loop; other site 768490004693 ATP binding site [chemical binding]; other site 768490004694 Q-loop/lid; other site 768490004695 ABC transporter signature motif; other site 768490004696 Walker B; other site 768490004697 D-loop; other site 768490004698 H-loop/switch region; other site 768490004699 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768490004700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490004701 dimer interface [polypeptide binding]; other site 768490004702 conserved gate region; other site 768490004703 putative PBP binding loops; other site 768490004704 ABC-ATPase subunit interface; other site 768490004705 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 768490004706 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768490004707 substrate binding pocket [chemical binding]; other site 768490004708 membrane-bound complex binding site; other site 768490004709 hinge residues; other site 768490004710 hypothetical protein; Provisional; Region: PRK11019 768490004711 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 768490004712 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 768490004713 dimerization interface [polypeptide binding]; other site 768490004714 DPS ferroxidase diiron center [ion binding]; other site 768490004715 ion pore; other site 768490004716 AAA domain; Region: AAA_17; pfam13207 768490004717 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 768490004718 threonine and homoserine efflux system; Provisional; Region: PRK10532 768490004719 EamA-like transporter family; Region: EamA; pfam00892 768490004720 outer membrane protein X; Provisional; Region: ompX; PRK09408 768490004721 Predicted amidohydrolase [General function prediction only]; Region: COG0388 768490004722 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_7; cd07585 768490004723 putative active site [active] 768490004724 catalytic triad [active] 768490004725 putative dimer interface [polypeptide binding]; other site 768490004726 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490004727 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490004728 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 768490004729 dimerization interface [polypeptide binding]; other site 768490004730 substrate binding pocket [chemical binding]; other site 768490004731 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768490004732 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768490004733 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 768490004734 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 768490004735 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 768490004736 Moco binding site; other site 768490004737 metal coordination site [ion binding]; other site 768490004738 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 768490004739 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768490004740 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768490004741 dimerization interface [polypeptide binding]; other site 768490004742 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768490004743 dimer interface [polypeptide binding]; other site 768490004744 phosphorylation site [posttranslational modification] 768490004745 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490004746 ATP binding site [chemical binding]; other site 768490004747 Mg2+ binding site [ion binding]; other site 768490004748 G-X-G motif; other site 768490004749 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768490004750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490004751 active site 768490004752 phosphorylation site [posttranslational modification] 768490004753 intermolecular recognition site; other site 768490004754 dimerization interface [polypeptide binding]; other site 768490004755 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768490004756 DNA binding site [nucleotide binding] 768490004757 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 768490004758 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 768490004759 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 768490004760 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 768490004761 Moco binding site; other site 768490004762 metal coordination site [ion binding]; other site 768490004763 choline transport protein BetT; Provisional; Region: PRK09928 768490004764 transcriptional regulator BetI; Validated; Region: PRK00767 768490004765 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768490004766 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 768490004767 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 768490004768 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 768490004769 tetrameric interface [polypeptide binding]; other site 768490004770 NAD binding site [chemical binding]; other site 768490004771 catalytic residues [active] 768490004772 choline dehydrogenase; Validated; Region: PRK02106 768490004773 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 768490004774 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 768490004775 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 768490004776 active site 768490004777 FMN binding site [chemical binding]; other site 768490004778 substrate binding site [chemical binding]; other site 768490004779 3Fe-4S cluster binding site [ion binding]; other site 768490004780 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 768490004781 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 768490004782 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768490004783 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 768490004784 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 768490004785 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 768490004786 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 768490004787 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 768490004788 PapC N-terminal domain; Region: PapC_N; pfam13954 768490004789 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 768490004790 PapC C-terminal domain; Region: PapC_C; pfam13953 768490004791 putative major fimbrial protein SthE; Provisional; Region: PRK15292 768490004792 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 768490004793 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 768490004794 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490004795 malate:quinone oxidoreductase; Validated; Region: PRK05257 768490004796 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 768490004797 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768490004798 NADH(P)-binding; Region: NAD_binding_10; pfam13460 768490004799 NAD(P) binding site [chemical binding]; other site 768490004800 active site 768490004801 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768490004802 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768490004803 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768490004804 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768490004805 alkaline phosphatase; Provisional; Region: PRK10518 768490004806 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 768490004807 dimer interface [polypeptide binding]; other site 768490004808 active site 768490004809 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 768490004810 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 768490004811 C-terminal domain interface [polypeptide binding]; other site 768490004812 GSH binding site (G-site) [chemical binding]; other site 768490004813 dimer interface [polypeptide binding]; other site 768490004814 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 768490004815 dimer interface [polypeptide binding]; other site 768490004816 N-terminal domain interface [polypeptide binding]; other site 768490004817 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768490004818 dimerization interface [polypeptide binding]; other site 768490004819 putative DNA binding site [nucleotide binding]; other site 768490004820 putative Zn2+ binding site [ion binding]; other site 768490004821 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 768490004822 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 768490004823 Isochorismatase family; Region: Isochorismatase; pfam00857 768490004824 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 768490004825 catalytic triad [active] 768490004826 conserved cis-peptide bond; other site 768490004827 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490004828 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490004829 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768490004830 putative effector binding pocket; other site 768490004831 dimerization interface [polypeptide binding]; other site 768490004832 AAA domain; Region: AAA_33; pfam13671 768490004833 AAA domain; Region: AAA_17; pfam13207 768490004834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490004835 metabolite-proton symporter; Region: 2A0106; TIGR00883 768490004836 putative substrate translocation pore; other site 768490004837 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490004838 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490004839 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768490004840 putative effector binding pocket; other site 768490004841 dimerization interface [polypeptide binding]; other site 768490004842 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 768490004843 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768490004844 Walker A/P-loop; other site 768490004845 ATP binding site [chemical binding]; other site 768490004846 Q-loop/lid; other site 768490004847 ABC transporter signature motif; other site 768490004848 Walker B; other site 768490004849 D-loop; other site 768490004850 H-loop/switch region; other site 768490004851 ABC transporter; Region: ABC_tran_2; pfam12848 768490004852 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768490004853 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 768490004854 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 768490004855 ATP binding site [chemical binding]; other site 768490004856 substrate interface [chemical binding]; other site 768490004857 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 768490004858 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 768490004859 dimer interface [polypeptide binding]; other site 768490004860 putative functional site; other site 768490004861 putative MPT binding site; other site 768490004862 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 768490004863 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 768490004864 catalytic nucleophile [active] 768490004865 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 768490004866 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768490004867 Walker A/P-loop; other site 768490004868 ATP binding site [chemical binding]; other site 768490004869 Q-loop/lid; other site 768490004870 ABC transporter signature motif; other site 768490004871 Walker B; other site 768490004872 D-loop; other site 768490004873 H-loop/switch region; other site 768490004874 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768490004875 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768490004876 Walker A/P-loop; other site 768490004877 ATP binding site [chemical binding]; other site 768490004878 Q-loop/lid; other site 768490004879 ABC transporter signature motif; other site 768490004880 Walker B; other site 768490004881 D-loop; other site 768490004882 H-loop/switch region; other site 768490004883 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768490004884 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 768490004885 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 768490004886 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 768490004887 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490004888 dimer interface [polypeptide binding]; other site 768490004889 conserved gate region; other site 768490004890 putative PBP binding loops; other site 768490004891 ABC-ATPase subunit interface; other site 768490004892 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 768490004893 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490004894 dimer interface [polypeptide binding]; other site 768490004895 conserved gate region; other site 768490004896 putative PBP binding loops; other site 768490004897 ABC-ATPase subunit interface; other site 768490004898 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 768490004899 CcdB protein; Region: CcdB; pfam01845 768490004900 S-formylglutathione hydrolase; Region: PLN02442 768490004901 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 768490004902 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 768490004903 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 768490004904 substrate binding site [chemical binding]; other site 768490004905 catalytic Zn binding site [ion binding]; other site 768490004906 NAD binding site [chemical binding]; other site 768490004907 structural Zn binding site [ion binding]; other site 768490004908 dimer interface [polypeptide binding]; other site 768490004909 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490004910 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490004911 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 768490004912 putative dimerization interface [polypeptide binding]; other site 768490004913 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490004914 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768490004915 putative substrate translocation pore; other site 768490004916 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 768490004917 active site 768490004918 Predicted membrane protein [Function unknown]; Region: COG2311 768490004919 hypothetical protein; Provisional; Region: PRK10835 768490004920 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 768490004921 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768490004922 DNA binding site [nucleotide binding] 768490004923 domain linker motif; other site 768490004924 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 768490004925 dimerization interface (closed form) [polypeptide binding]; other site 768490004926 ligand binding site [chemical binding]; other site 768490004927 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 768490004928 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 768490004929 ligand binding site [chemical binding]; other site 768490004930 calcium binding site [ion binding]; other site 768490004931 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768490004932 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 768490004933 Walker A/P-loop; other site 768490004934 ATP binding site [chemical binding]; other site 768490004935 Q-loop/lid; other site 768490004936 ABC transporter signature motif; other site 768490004937 Walker B; other site 768490004938 D-loop; other site 768490004939 H-loop/switch region; other site 768490004940 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768490004941 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768490004942 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768490004943 TM-ABC transporter signature motif; other site 768490004944 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 768490004945 putative active site [active] 768490004946 malate dehydrogenase; Provisional; Region: PRK13529 768490004947 Malic enzyme, N-terminal domain; Region: malic; pfam00390 768490004948 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 768490004949 NAD(P) binding site [chemical binding]; other site 768490004950 cytidine deaminase; Provisional; Region: PRK09027 768490004951 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 768490004952 active site 768490004953 catalytic motif [active] 768490004954 Zn binding site [ion binding]; other site 768490004955 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 768490004956 active site 768490004957 catalytic motif [active] 768490004958 Zn binding site [ion binding]; other site 768490004959 hypothetical protein; Provisional; Region: PRK10711 768490004960 hypothetical protein; Provisional; Region: PRK01821 768490004961 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768490004962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490004963 putative substrate translocation pore; other site 768490004964 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 768490004965 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 768490004966 putative ligand binding site [chemical binding]; other site 768490004967 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 768490004968 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 768490004969 active site 768490004970 HIGH motif; other site 768490004971 KMSKS motif; other site 768490004972 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 768490004973 tRNA binding surface [nucleotide binding]; other site 768490004974 anticodon binding site; other site 768490004975 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 768490004976 dimer interface [polypeptide binding]; other site 768490004977 putative tRNA-binding site [nucleotide binding]; other site 768490004978 antiporter inner membrane protein; Provisional; Region: PRK11670 768490004979 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 768490004980 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 768490004981 active site 768490004982 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 768490004983 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 768490004984 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 768490004985 ATP-binding site [chemical binding]; other site 768490004986 Sugar specificity; other site 768490004987 Pyrimidine base specificity; other site 768490004988 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 768490004989 trimer interface [polypeptide binding]; other site 768490004990 active site 768490004991 putative assembly protein; Provisional; Region: PRK10833 768490004992 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 768490004993 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 768490004994 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 768490004995 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 768490004996 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 768490004997 FOG: CBS domain [General function prediction only]; Region: COG0517 768490004998 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 768490004999 Transporter associated domain; Region: CorC_HlyC; smart01091 768490005000 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 768490005001 active site 768490005002 tetramer interface; other site 768490005003 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 768490005004 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 768490005005 active site 768490005006 tetramer interface; other site 768490005007 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 768490005008 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 768490005009 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 768490005010 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768490005011 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 768490005012 polysaccharide export protein Wza; Provisional; Region: PRK15078 768490005013 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 768490005014 SLBB domain; Region: SLBB; pfam10531 768490005015 SLBB domain; Region: SLBB; pfam10531 768490005016 Low molecular weight phosphatase family; Region: LMWPc; cd00115 768490005017 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 768490005018 active site 768490005019 tyrosine kinase; Provisional; Region: PRK11519 768490005020 Chain length determinant protein; Region: Wzz; pfam02706 768490005021 Chain length determinant protein; Region: Wzz; cl15801 768490005022 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 768490005023 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 768490005024 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 768490005025 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 768490005026 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768490005027 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 768490005028 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768490005029 putative ADP-binding pocket [chemical binding]; other site 768490005030 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 768490005031 Bacterial sugar transferase; Region: Bac_transf; pfam02397 768490005032 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 768490005033 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 768490005034 Walker A/P-loop; other site 768490005035 ATP binding site [chemical binding]; other site 768490005036 Q-loop/lid; other site 768490005037 ABC transporter signature motif; other site 768490005038 Walker B; other site 768490005039 D-loop; other site 768490005040 H-loop/switch region; other site 768490005041 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 768490005042 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768490005043 HlyD family secretion protein; Region: HlyD_3; pfam13437 768490005044 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 768490005045 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 768490005046 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 768490005047 Substrate binding site; other site 768490005048 Cupin domain; Region: Cupin_2; cl17218 768490005049 phosphomannomutase CpsG; Provisional; Region: PRK15414 768490005050 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 768490005051 active site 768490005052 substrate binding site [chemical binding]; other site 768490005053 metal binding site [ion binding]; metal-binding site 768490005054 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 768490005055 UDP-glucose 4-epimerase; Region: PLN02240 768490005056 NAD binding site [chemical binding]; other site 768490005057 homodimer interface [polypeptide binding]; other site 768490005058 active site 768490005059 substrate binding site [chemical binding]; other site 768490005060 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 768490005061 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 768490005062 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 768490005063 NADP binding site [chemical binding]; other site 768490005064 active site 768490005065 putative substrate binding site [chemical binding]; other site 768490005066 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 768490005067 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 768490005068 active site 768490005069 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 768490005070 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 768490005071 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 768490005072 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 768490005073 Walker A/P-loop; other site 768490005074 ATP binding site [chemical binding]; other site 768490005075 Q-loop/lid; other site 768490005076 ABC transporter signature motif; other site 768490005077 Walker B; other site 768490005078 D-loop; other site 768490005079 H-loop/switch region; other site 768490005080 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 768490005081 putative carbohydrate binding site [chemical binding]; other site 768490005082 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 768490005083 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 768490005084 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 768490005085 active site 768490005086 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768490005087 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 768490005088 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 768490005089 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 768490005090 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 768490005091 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 768490005092 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 768490005093 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 768490005094 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 768490005095 metal binding site [ion binding]; metal-binding site 768490005096 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 768490005097 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 768490005098 substrate binding site [chemical binding]; other site 768490005099 glutamase interaction surface [polypeptide binding]; other site 768490005100 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 768490005101 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 768490005102 catalytic residues [active] 768490005103 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 768490005104 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 768490005105 putative active site [active] 768490005106 oxyanion strand; other site 768490005107 catalytic triad [active] 768490005108 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 768490005109 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768490005110 active site 768490005111 motif I; other site 768490005112 motif II; other site 768490005113 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 768490005114 putative active site pocket [active] 768490005115 4-fold oligomerization interface [polypeptide binding]; other site 768490005116 metal binding residues [ion binding]; metal-binding site 768490005117 3-fold/trimer interface [polypeptide binding]; other site 768490005118 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 768490005119 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768490005120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490005121 homodimer interface [polypeptide binding]; other site 768490005122 catalytic residue [active] 768490005123 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 768490005124 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 768490005125 NAD binding site [chemical binding]; other site 768490005126 dimerization interface [polypeptide binding]; other site 768490005127 product binding site; other site 768490005128 substrate binding site [chemical binding]; other site 768490005129 zinc binding site [ion binding]; other site 768490005130 catalytic residues [active] 768490005131 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 768490005132 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 768490005133 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 768490005134 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768490005135 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 768490005136 putative NAD(P) binding site [chemical binding]; other site 768490005137 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490005138 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490005139 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768490005140 dimerization interface [polypeptide binding]; other site 768490005141 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 768490005142 agmatinase; Region: agmatinase; TIGR01230 768490005143 oligomer interface [polypeptide binding]; other site 768490005144 putative active site [active] 768490005145 Mn binding site [ion binding]; other site 768490005146 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 768490005147 Na binding site [ion binding]; other site 768490005148 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 768490005149 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 768490005150 oligomer interface [polypeptide binding]; other site 768490005151 metal binding site [ion binding]; metal-binding site 768490005152 metal binding site [ion binding]; metal-binding site 768490005153 putative Cl binding site [ion binding]; other site 768490005154 basic sphincter; other site 768490005155 hydrophobic gate; other site 768490005156 periplasmic entrance; other site 768490005157 putative acetyltransferase; Provisional; Region: PRK03624 768490005158 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490005159 Coenzyme A binding pocket [chemical binding]; other site 768490005160 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 768490005161 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 768490005162 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 768490005163 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 768490005164 putative C-terminal domain interface [polypeptide binding]; other site 768490005165 putative GSH binding site (G-site) [chemical binding]; other site 768490005166 putative dimer interface [polypeptide binding]; other site 768490005167 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 768490005168 putative N-terminal domain interface [polypeptide binding]; other site 768490005169 putative dimer interface [polypeptide binding]; other site 768490005170 putative substrate binding pocket (H-site) [chemical binding]; other site 768490005171 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 768490005172 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 768490005173 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 768490005174 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 768490005175 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 768490005176 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 768490005177 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 768490005178 homodimer interface [polypeptide binding]; other site 768490005179 substrate-cofactor binding pocket; other site 768490005180 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490005181 catalytic residue [active] 768490005182 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 768490005183 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 768490005184 dimer interface [polypeptide binding]; other site 768490005185 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490005186 catalytic residue [active] 768490005187 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 768490005188 FOG: CBS domain [General function prediction only]; Region: COG0517 768490005189 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 768490005190 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 768490005191 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 768490005192 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 768490005193 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 768490005194 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 768490005195 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 768490005196 serine transporter; Region: stp; TIGR00814 768490005197 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 768490005198 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 768490005199 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 768490005200 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 768490005201 intersubunit interface [polypeptide binding]; other site 768490005202 active site 768490005203 catalytic residue [active] 768490005204 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 768490005205 active site 768490005206 catalytic residues [active] 768490005207 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 768490005208 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 768490005209 active site 768490005210 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 768490005211 active site 768490005212 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 768490005213 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 768490005214 secondary substrate binding site; other site 768490005215 primary substrate binding site; other site 768490005216 inhibition loop; other site 768490005217 dimerization interface [polypeptide binding]; other site 768490005218 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 768490005219 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 768490005220 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768490005221 catalytic residue [active] 768490005222 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 768490005223 Predicted transcriptional regulator [Transcription]; Region: COG3655 768490005224 sequence-specific DNA binding site [nucleotide binding]; other site 768490005225 salt bridge; other site 768490005226 Fucose-binding lectin II (PA-IIL); Region: PA-IIL; pfam07472 768490005227 putative transporter; Provisional; Region: PRK04972 768490005228 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 768490005229 TrkA-C domain; Region: TrkA_C; pfam02080 768490005230 TrkA-C domain; Region: TrkA_C; pfam02080 768490005231 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 768490005232 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 768490005233 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 768490005234 GSH binding site [chemical binding]; other site 768490005235 catalytic residues [active] 768490005236 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 768490005237 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 768490005238 RimK-like ATP-grasp domain; Region: RimK; pfam08443 768490005239 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 768490005240 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 768490005241 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 768490005242 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 768490005243 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 768490005244 Walker A/P-loop; other site 768490005245 ATP binding site [chemical binding]; other site 768490005246 Q-loop/lid; other site 768490005247 ABC transporter signature motif; other site 768490005248 Walker B; other site 768490005249 D-loop; other site 768490005250 H-loop/switch region; other site 768490005251 TOBE domain; Region: TOBE_2; pfam08402 768490005252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490005253 dimer interface [polypeptide binding]; other site 768490005254 conserved gate region; other site 768490005255 putative PBP binding loops; other site 768490005256 ABC-ATPase subunit interface; other site 768490005257 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 768490005258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490005259 dimer interface [polypeptide binding]; other site 768490005260 conserved gate region; other site 768490005261 putative PBP binding loops; other site 768490005262 ABC-ATPase subunit interface; other site 768490005263 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 768490005264 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 768490005265 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490005266 S-adenosylmethionine binding site [chemical binding]; other site 768490005267 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 768490005268 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768490005269 substrate binding pocket [chemical binding]; other site 768490005270 membrane-bound complex binding site; other site 768490005271 hinge residues; other site 768490005272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490005273 dimer interface [polypeptide binding]; other site 768490005274 conserved gate region; other site 768490005275 putative PBP binding loops; other site 768490005276 ABC-ATPase subunit interface; other site 768490005277 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768490005278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490005279 dimer interface [polypeptide binding]; other site 768490005280 conserved gate region; other site 768490005281 putative PBP binding loops; other site 768490005282 ABC-ATPase subunit interface; other site 768490005283 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 768490005284 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768490005285 substrate binding pocket [chemical binding]; other site 768490005286 membrane-bound complex binding site; other site 768490005287 hinge residues; other site 768490005288 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 768490005289 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768490005290 Walker A/P-loop; other site 768490005291 ATP binding site [chemical binding]; other site 768490005292 Q-loop/lid; other site 768490005293 ABC transporter signature motif; other site 768490005294 Walker B; other site 768490005295 D-loop; other site 768490005296 H-loop/switch region; other site 768490005297 putative lipoprotein; Provisional; Region: PRK10533 768490005298 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768490005299 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768490005300 dimerization interface [polypeptide binding]; other site 768490005301 putative DNA binding site [nucleotide binding]; other site 768490005302 putative Zn2+ binding site [ion binding]; other site 768490005303 AsnC family; Region: AsnC_trans_reg; pfam01037 768490005304 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 768490005305 hypothetical protein; Provisional; Region: PRK02877 768490005306 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 768490005307 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 768490005308 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 768490005309 amidase catalytic site [active] 768490005310 Zn binding residues [ion binding]; other site 768490005311 substrate binding site [chemical binding]; other site 768490005312 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768490005313 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768490005314 NAD(P) binding site [chemical binding]; other site 768490005315 active site 768490005316 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 768490005317 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 768490005318 putative NAD(P) binding site [chemical binding]; other site 768490005319 putative active site [active] 768490005320 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 768490005321 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 768490005322 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 768490005323 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 768490005324 tetramer interface [polypeptide binding]; other site 768490005325 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490005326 catalytic residue [active] 768490005327 pyruvate dehydrogenase; Provisional; Region: PRK09124 768490005328 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 768490005329 PYR/PP interface [polypeptide binding]; other site 768490005330 dimer interface [polypeptide binding]; other site 768490005331 tetramer interface [polypeptide binding]; other site 768490005332 TPP binding site [chemical binding]; other site 768490005333 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768490005334 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 768490005335 TPP-binding site [chemical binding]; other site 768490005336 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 768490005337 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 768490005338 FAD binding pocket [chemical binding]; other site 768490005339 FAD binding motif [chemical binding]; other site 768490005340 phosphate binding motif [ion binding]; other site 768490005341 beta-alpha-beta structure motif; other site 768490005342 NAD binding pocket [chemical binding]; other site 768490005343 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768490005344 catalytic loop [active] 768490005345 iron binding site [ion binding]; other site 768490005346 hybrid cluster protein; Provisional; Region: PRK05290 768490005347 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768490005348 ACS interaction site; other site 768490005349 CODH interaction site; other site 768490005350 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768490005351 ACS interaction site; other site 768490005352 CODH interaction site; other site 768490005353 metal cluster binding site [ion binding]; other site 768490005354 Predicted membrane protein [Function unknown]; Region: COG2431 768490005355 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 768490005356 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 768490005357 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 768490005358 putative active site [active] 768490005359 putative metal-binding site [ion binding]; other site 768490005360 Protein of unknown function (DUF535); Region: DUF535; pfam04393 768490005361 macrolide transporter subunit MacA; Provisional; Region: PRK11578 768490005362 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768490005363 HlyD family secretion protein; Region: HlyD_3; pfam13437 768490005364 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 768490005365 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768490005366 Walker A/P-loop; other site 768490005367 ATP binding site [chemical binding]; other site 768490005368 Q-loop/lid; other site 768490005369 ABC transporter signature motif; other site 768490005370 Walker B; other site 768490005371 D-loop; other site 768490005372 H-loop/switch region; other site 768490005373 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768490005374 FtsX-like permease family; Region: FtsX; pfam02687 768490005375 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768490005376 DNA-binding site [nucleotide binding]; DNA binding site 768490005377 RNA-binding motif; other site 768490005378 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 768490005379 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 768490005380 Clp amino terminal domain; Region: Clp_N; pfam02861 768490005381 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768490005382 Walker A motif; other site 768490005383 ATP binding site [chemical binding]; other site 768490005384 Walker B motif; other site 768490005385 arginine finger; other site 768490005386 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768490005387 Walker A motif; other site 768490005388 ATP binding site [chemical binding]; other site 768490005389 Walker B motif; other site 768490005390 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 768490005391 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 768490005392 rRNA binding site [nucleotide binding]; other site 768490005393 predicted 30S ribosome binding site; other site 768490005394 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 768490005395 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 768490005396 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768490005397 Walker A/P-loop; other site 768490005398 ATP binding site [chemical binding]; other site 768490005399 Q-loop/lid; other site 768490005400 ABC transporter signature motif; other site 768490005401 Walker B; other site 768490005402 D-loop; other site 768490005403 H-loop/switch region; other site 768490005404 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 768490005405 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768490005406 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768490005407 Walker A/P-loop; other site 768490005408 ATP binding site [chemical binding]; other site 768490005409 Q-loop/lid; other site 768490005410 ABC transporter signature motif; other site 768490005411 Walker B; other site 768490005412 D-loop; other site 768490005413 H-loop/switch region; other site 768490005414 glutathionine S-transferase; Provisional; Region: PRK10542 768490005415 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 768490005416 C-terminal domain interface [polypeptide binding]; other site 768490005417 GSH binding site (G-site) [chemical binding]; other site 768490005418 dimer interface [polypeptide binding]; other site 768490005419 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 768490005420 dimer interface [polypeptide binding]; other site 768490005421 N-terminal domain interface [polypeptide binding]; other site 768490005422 substrate binding pocket (H-site) [chemical binding]; other site 768490005423 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490005424 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490005425 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768490005426 dimerization interface [polypeptide binding]; other site 768490005427 thioredoxin reductase; Provisional; Region: PRK10262 768490005428 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768490005429 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768490005430 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 768490005431 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768490005432 putative DNA binding site [nucleotide binding]; other site 768490005433 putative Zn2+ binding site [ion binding]; other site 768490005434 AsnC family; Region: AsnC_trans_reg; pfam01037 768490005435 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 768490005436 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 768490005437 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 768490005438 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 768490005439 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 768490005440 recombination factor protein RarA; Reviewed; Region: PRK13342 768490005441 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768490005442 Walker A motif; other site 768490005443 ATP binding site [chemical binding]; other site 768490005444 Walker B motif; other site 768490005445 arginine finger; other site 768490005446 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 768490005447 seryl-tRNA synthetase; Provisional; Region: PRK05431 768490005448 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 768490005449 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 768490005450 dimer interface [polypeptide binding]; other site 768490005451 active site 768490005452 motif 1; other site 768490005453 motif 2; other site 768490005454 motif 3; other site 768490005455 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 768490005456 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768490005457 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768490005458 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490005459 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 768490005460 putative MFS family transporter protein; Provisional; Region: PRK03633 768490005461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490005462 putative substrate translocation pore; other site 768490005463 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 768490005464 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768490005465 FeS/SAM binding site; other site 768490005466 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 768490005467 Pyruvate formate lyase 1; Region: PFL1; cd01678 768490005468 coenzyme A binding site [chemical binding]; other site 768490005469 active site 768490005470 catalytic residues [active] 768490005471 glycine loop; other site 768490005472 formate transporter; Provisional; Region: PRK10805 768490005473 uncharacterized domain; Region: TIGR00702 768490005474 YcaO-like family; Region: YcaO; pfam02624 768490005475 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 768490005476 homodimer interface [polypeptide binding]; other site 768490005477 active site 768490005478 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 768490005479 homodimer interface [polypeptide binding]; other site 768490005480 substrate-cofactor binding pocket; other site 768490005481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490005482 catalytic residue [active] 768490005483 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 768490005484 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 768490005485 hinge; other site 768490005486 active site 768490005487 cytidylate kinase; Provisional; Region: cmk; PRK00023 768490005488 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 768490005489 CMP-binding site; other site 768490005490 The sites determining sugar specificity; other site 768490005491 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 768490005492 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 768490005493 RNA binding site [nucleotide binding]; other site 768490005494 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 768490005495 RNA binding site [nucleotide binding]; other site 768490005496 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 768490005497 RNA binding site [nucleotide binding]; other site 768490005498 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 768490005499 RNA binding site [nucleotide binding]; other site 768490005500 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 768490005501 RNA binding site [nucleotide binding]; other site 768490005502 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 768490005503 IHF dimer interface [polypeptide binding]; other site 768490005504 IHF - DNA interface [nucleotide binding]; other site 768490005505 ComEC family competence protein; Provisional; Region: PRK11539 768490005506 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 768490005507 Competence protein; Region: Competence; pfam03772 768490005508 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 768490005509 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 768490005510 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768490005511 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 768490005512 Walker A/P-loop; other site 768490005513 ATP binding site [chemical binding]; other site 768490005514 Q-loop/lid; other site 768490005515 ABC transporter signature motif; other site 768490005516 Walker B; other site 768490005517 D-loop; other site 768490005518 H-loop/switch region; other site 768490005519 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 768490005520 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 768490005521 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 768490005522 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 768490005523 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768490005524 DNA-binding site [nucleotide binding]; DNA binding site 768490005525 RNA-binding motif; other site 768490005526 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768490005527 DNA-binding site [nucleotide binding]; DNA binding site 768490005528 RNA-binding motif; other site 768490005529 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 768490005530 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 768490005531 Trm112p-like protein; Region: Trm112p; cl01066 768490005532 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 768490005533 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 768490005534 Ligand binding site; other site 768490005535 oligomer interface; other site 768490005536 hypothetical protein; Provisional; Region: PRK10593 768490005537 Uncharacterized conserved protein [Function unknown]; Region: COG1434 768490005538 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 768490005539 putative active site [active] 768490005540 Methyltransferase domain; Region: Methyltransf_31; pfam13847 768490005541 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490005542 S-adenosylmethionine binding site [chemical binding]; other site 768490005543 condesin subunit F; Provisional; Region: PRK05260 768490005544 condesin subunit E; Provisional; Region: PRK05256 768490005545 cell division protein MukB; Provisional; Region: mukB; PRK04863 768490005546 P-loop containing region of AAA domain; Region: AAA_29; cl17516 768490005547 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 768490005548 murein L,D-transpeptidase; Provisional; Region: PRK10594 768490005549 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 768490005550 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 768490005551 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 768490005552 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 768490005553 Peptidase M15; Region: Peptidase_M15_3; cl01194 768490005554 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 768490005555 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 768490005556 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768490005557 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490005558 homodimer interface [polypeptide binding]; other site 768490005559 catalytic residue [active] 768490005560 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 768490005561 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 768490005562 trimer interface [polypeptide binding]; other site 768490005563 eyelet of channel; other site 768490005564 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 768490005565 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 768490005566 putative dimer interface [polypeptide binding]; other site 768490005567 putative anticodon binding site; other site 768490005568 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 768490005569 homodimer interface [polypeptide binding]; other site 768490005570 motif 1; other site 768490005571 motif 2; other site 768490005572 active site 768490005573 motif 3; other site 768490005574 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 768490005575 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 768490005576 active site 768490005577 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768490005578 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768490005579 metal binding site [ion binding]; metal-binding site 768490005580 active site 768490005581 I-site; other site 768490005582 aminopeptidase N; Provisional; Region: pepN; PRK14015 768490005583 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 768490005584 active site 768490005585 Zn binding site [ion binding]; other site 768490005586 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 768490005587 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 768490005588 Walker A/P-loop; other site 768490005589 ATP binding site [chemical binding]; other site 768490005590 Q-loop/lid; other site 768490005591 ABC transporter signature motif; other site 768490005592 Walker B; other site 768490005593 D-loop; other site 768490005594 H-loop/switch region; other site 768490005595 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 768490005596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490005597 dimer interface [polypeptide binding]; other site 768490005598 conserved gate region; other site 768490005599 putative PBP binding loops; other site 768490005600 ABC-ATPase subunit interface; other site 768490005601 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 768490005602 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 768490005603 active site 768490005604 dimer interface [polypeptide binding]; other site 768490005605 non-prolyl cis peptide bond; other site 768490005606 insertion regions; other site 768490005607 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 768490005608 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768490005609 substrate binding pocket [chemical binding]; other site 768490005610 membrane-bound complex binding site; other site 768490005611 hinge residues; other site 768490005612 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 768490005613 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768490005614 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 768490005615 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 768490005616 quinone interaction residues [chemical binding]; other site 768490005617 active site 768490005618 catalytic residues [active] 768490005619 FMN binding site [chemical binding]; other site 768490005620 substrate binding site [chemical binding]; other site 768490005621 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 768490005622 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 768490005623 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 768490005624 MOSC domain; Region: MOSC; pfam03473 768490005625 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768490005626 catalytic loop [active] 768490005627 iron binding site [ion binding]; other site 768490005628 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 768490005629 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 768490005630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490005631 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490005632 S-adenosylmethionine binding site [chemical binding]; other site 768490005633 ABC transporter ATPase component; Reviewed; Region: PRK11147 768490005634 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768490005635 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768490005636 Walker A/P-loop; other site 768490005637 Walker A/P-loop; other site 768490005638 ATP binding site [chemical binding]; other site 768490005639 ATP binding site [chemical binding]; other site 768490005640 Q-loop/lid; other site 768490005641 Q-loop/lid; other site 768490005642 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768490005643 ABC transporter signature motif; other site 768490005644 Walker B; other site 768490005645 D-loop; other site 768490005646 ABC transporter; Region: ABC_tran_2; pfam12848 768490005647 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768490005648 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 768490005649 Paraquat-inducible protein A; Region: PqiA; pfam04403 768490005650 Paraquat-inducible protein A; Region: PqiA; pfam04403 768490005651 paraquat-inducible protein B; Provisional; Region: PRK10807 768490005652 mce related protein; Region: MCE; pfam02470 768490005653 mce related protein; Region: MCE; pfam02470 768490005654 mce related protein; Region: MCE; pfam02470 768490005655 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 768490005656 Protein of unknown function (DUF330); Region: DUF330; pfam03886 768490005657 Ribosome modulation factor; Region: RMF; pfam04957 768490005658 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 768490005659 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 768490005660 dimer interface [polypeptide binding]; other site 768490005661 active site 768490005662 Predicted transcriptional regulators [Transcription]; Region: COG1733 768490005663 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 768490005664 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 768490005665 active site 2 [active] 768490005666 dimer interface [polypeptide binding]; other site 768490005667 active site 1 [active] 768490005668 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 768490005669 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 768490005670 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 768490005671 outer membrane protein A; Reviewed; Region: PRK10808 768490005672 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 768490005673 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 768490005674 ligand binding site [chemical binding]; other site 768490005675 SOS cell division inhibitor; Provisional; Region: PRK10595 768490005676 TfoX N-terminal domain; Region: TfoX_N; pfam04993 768490005677 TfoX C-terminal domain; Region: TfoX_C; pfam04994 768490005678 TIGR01666 family membrane protein; Region: YCCS 768490005679 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 768490005680 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 768490005681 Predicted membrane protein [Function unknown]; Region: COG3304 768490005682 Domain of unknown function (DUF307); Region: DUF307; pfam03733 768490005683 Domain of unknown function (DUF307); Region: DUF307; pfam03733 768490005684 DNA helicase IV; Provisional; Region: helD; PRK11054 768490005685 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 768490005686 Part of AAA domain; Region: AAA_19; pfam13245 768490005687 Family description; Region: UvrD_C_2; pfam13538 768490005688 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 768490005689 active site 768490005690 dimer interfaces [polypeptide binding]; other site 768490005691 catalytic residues [active] 768490005692 hypothetical protein; Provisional; Region: PRK03641 768490005693 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 768490005694 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 768490005695 heat shock protein HspQ; Provisional; Region: PRK14129 768490005696 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 768490005697 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 768490005698 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 768490005699 putative RNA binding site [nucleotide binding]; other site 768490005700 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490005701 S-adenosylmethionine binding site [chemical binding]; other site 768490005702 acylphosphatase; Provisional; Region: PRK14426 768490005703 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 768490005704 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 768490005705 YccA-like proteins; Region: YccA_like; cd10433 768490005706 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 768490005707 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 768490005708 hypothetical protein; Provisional; Region: PRK14851 768490005709 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 768490005710 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 768490005711 REDY-like protein HapK; Region: HapK; pfam11639 768490005712 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 768490005713 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 768490005714 active site 768490005715 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 768490005716 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 768490005717 acyl-activating enzyme (AAE) consensus motif; other site 768490005718 AMP binding site [chemical binding]; other site 768490005719 Phosphopantetheine attachment site; Region: PP-binding; cl09936 768490005720 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 768490005721 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768490005722 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768490005723 catalytic residue [active] 768490005724 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 768490005725 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490005726 S-adenosylmethionine binding site [chemical binding]; other site 768490005727 Predicted dehydrogenase [General function prediction only]; Region: COG5322 768490005728 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 768490005729 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768490005730 inhibitor-cofactor binding pocket; inhibition site 768490005731 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490005732 catalytic residue [active] 768490005733 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 768490005734 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 768490005735 TPP-binding site [chemical binding]; other site 768490005736 phosphoenolpyruvate synthase; Validated; Region: PRK06241 768490005737 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 768490005738 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 768490005739 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 768490005740 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 768490005741 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 768490005742 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 768490005743 active site 768490005744 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 768490005745 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 768490005746 active site 768490005747 substrate binding site [chemical binding]; other site 768490005748 Mg2+ binding site [ion binding]; other site 768490005749 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 768490005750 LysE type translocator; Region: LysE; cl00565 768490005751 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 768490005752 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490005753 The C-terminal substrate binding domain of LysR-type transcriptional regulator TrpI, which is involved in control of tryptophan synthesis, contains type 2 periplasmic binding fold; Region: PBP2_TrpI; cd08482 768490005754 putative dimerization interface [polypeptide binding]; other site 768490005755 putative substrate binding pocket [chemical binding]; other site 768490005756 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768490005757 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768490005758 non-specific DNA binding site [nucleotide binding]; other site 768490005759 salt bridge; other site 768490005760 sequence-specific DNA binding site [nucleotide binding]; other site 768490005761 Cupin domain; Region: Cupin_2; cl17218 768490005762 EamA-like transporter family; Region: EamA; pfam00892 768490005763 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 768490005764 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 768490005765 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 768490005766 pyrimidine utilization protein D; Region: RutD; TIGR03611 768490005767 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 768490005768 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 768490005769 homotrimer interaction site [polypeptide binding]; other site 768490005770 putative active site [active] 768490005771 Isochorismatase family; Region: Isochorismatase; pfam00857 768490005772 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 768490005773 catalytic triad [active] 768490005774 conserved cis-peptide bond; other site 768490005775 pyrimidine utilization protein A; Region: RutA; TIGR03612 768490005776 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 768490005777 active site 768490005778 dimer interface [polypeptide binding]; other site 768490005779 non-prolyl cis peptide bond; other site 768490005780 insertion regions; other site 768490005781 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 768490005782 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768490005783 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 768490005784 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 768490005785 TolA C-terminal; Region: TolA; pfam06519 768490005786 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 768490005787 Uncharacterized conserved protein [Function unknown]; Region: COG1359 768490005788 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768490005789 enoyl-CoA hydratase; Provisional; Region: PRK05870 768490005790 substrate binding site [chemical binding]; other site 768490005791 oxyanion hole (OAH) forming residues; other site 768490005792 trimer interface [polypeptide binding]; other site 768490005793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490005794 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768490005795 putative substrate translocation pore; other site 768490005796 5-aminolevulinate synthase; Validated; Region: PRK09064 768490005797 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 768490005798 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768490005799 catalytic residue [active] 768490005800 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 768490005801 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 768490005802 dimer interface [polypeptide binding]; other site 768490005803 active site 768490005804 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 768490005805 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 768490005806 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768490005807 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768490005808 transcriptional regulator TraR; Provisional; Region: PRK13870 768490005809 Autoinducer binding domain; Region: Autoind_bind; pfam03472 768490005810 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768490005811 DNA binding residues [nucleotide binding] 768490005812 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 768490005813 Ligand Binding Site [chemical binding]; other site 768490005814 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 768490005815 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 768490005816 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 768490005817 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 768490005818 dimer interface [polypeptide binding]; other site 768490005819 NADP binding site [chemical binding]; other site 768490005820 catalytic residues [active] 768490005821 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 768490005822 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 768490005823 inhibitor site; inhibition site 768490005824 active site 768490005825 dimer interface [polypeptide binding]; other site 768490005826 catalytic residue [active] 768490005827 PAS fold; Region: PAS_4; pfam08448 768490005828 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768490005829 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490005830 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 768490005831 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 768490005832 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 768490005833 hydroxyglutarate oxidase; Provisional; Region: PRK11728 768490005834 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 768490005835 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 768490005836 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 768490005837 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 768490005838 GlpM protein; Region: GlpM; pfam06942 768490005839 hypothetical protein; Provisional; Region: PRK10613 768490005840 response regulator; Provisional; Region: PRK09483 768490005841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490005842 active site 768490005843 phosphorylation site [posttranslational modification] 768490005844 intermolecular recognition site; other site 768490005845 dimerization interface [polypeptide binding]; other site 768490005846 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768490005847 DNA binding residues [nucleotide binding] 768490005848 dimerization interface [polypeptide binding]; other site 768490005849 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 768490005850 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 768490005851 GIY-YIG motif/motif A; other site 768490005852 active site 768490005853 catalytic site [active] 768490005854 putative DNA binding site [nucleotide binding]; other site 768490005855 metal binding site [ion binding]; metal-binding site 768490005856 UvrB/uvrC motif; Region: UVR; pfam02151 768490005857 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 768490005858 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 768490005859 phosphoethanolamine transferase; Provisional; Region: PRK11560 768490005860 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 768490005861 Sulfatase; Region: Sulfatase; pfam00884 768490005862 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 768490005863 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 768490005864 proline/glycine betaine transporter; Provisional; Region: PRK10642 768490005865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490005866 putative substrate translocation pore; other site 768490005867 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 768490005868 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 768490005869 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 768490005870 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768490005871 Walker A/P-loop; other site 768490005872 ATP binding site [chemical binding]; other site 768490005873 Q-loop/lid; other site 768490005874 ABC transporter signature motif; other site 768490005875 Walker B; other site 768490005876 D-loop; other site 768490005877 H-loop/switch region; other site 768490005878 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768490005879 FtsX-like permease family; Region: FtsX; pfam02687 768490005880 macrolide transporter subunit MacA; Provisional; Region: PRK11578 768490005881 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768490005882 HlyD family secretion protein; Region: HlyD_3; pfam13437 768490005883 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 768490005884 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 768490005885 GIY-YIG motif/motif A; other site 768490005886 active site 768490005887 catalytic site [active] 768490005888 putative DNA binding site [nucleotide binding]; other site 768490005889 metal binding site [ion binding]; metal-binding site 768490005890 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 768490005891 potassium/proton antiporter; Reviewed; Region: PRK05326 768490005892 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 768490005893 TrkA-C domain; Region: TrkA_C; pfam02080 768490005894 Transporter associated domain; Region: CorC_HlyC; smart01091 768490005895 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 768490005896 Acyltransferase family; Region: Acyl_transf_3; pfam01757 768490005897 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 768490005898 Acyltransferase family; Region: Acyl_transf_3; pfam01757 768490005899 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 768490005900 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 768490005901 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 768490005902 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 768490005903 Ligand binding site; other site 768490005904 DXD motif; other site 768490005905 lipoprotein; Provisional; Region: PRK10175 768490005906 MsyB protein; Region: MsyB; cl08181 768490005907 2-isopropylmalate synthase; Validated; Region: PRK03739 768490005908 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 768490005909 active site 768490005910 catalytic residues [active] 768490005911 metal binding site [ion binding]; metal-binding site 768490005912 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 768490005913 Cupin domain; Region: Cupin_2; cl17218 768490005914 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768490005915 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490005916 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768490005917 dimerization interface [polypeptide binding]; other site 768490005918 putative DNA binding site [nucleotide binding]; other site 768490005919 putative Zn2+ binding site [ion binding]; other site 768490005920 Predicted transporter component [General function prediction only]; Region: COG2391 768490005921 Sulphur transport; Region: Sulf_transp; pfam04143 768490005922 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768490005923 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 768490005924 active site 768490005925 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 768490005926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490005927 putative substrate translocation pore; other site 768490005928 POT family; Region: PTR2; cl17359 768490005929 drug efflux system protein MdtG; Provisional; Region: PRK09874 768490005930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490005931 putative substrate translocation pore; other site 768490005932 YCII-related domain; Region: YCII; cl00999 768490005933 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 768490005934 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 768490005935 putative acyl-acceptor binding pocket; other site 768490005936 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 768490005937 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 768490005938 active site 768490005939 FMN binding site [chemical binding]; other site 768490005940 substrate binding site [chemical binding]; other site 768490005941 homotetramer interface [polypeptide binding]; other site 768490005942 catalytic residue [active] 768490005943 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 768490005944 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 768490005945 active site residue [active] 768490005946 YceI-like domain; Region: YceI; cl01001 768490005947 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 768490005948 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 768490005949 Domain of unknown function DUF20; Region: UPF0118; pfam01594 768490005950 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 768490005951 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768490005952 DNA binding residues [nucleotide binding] 768490005953 dimerization interface [polypeptide binding]; other site 768490005954 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 768490005955 hydroxyglutarate oxidase; Provisional; Region: PRK11728 768490005956 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 768490005957 DNA damage-inducible protein I; Provisional; Region: PRK10597 768490005958 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 768490005959 active site 768490005960 substrate binding pocket [chemical binding]; other site 768490005961 dimer interface [polypeptide binding]; other site 768490005962 Uncharacterized conserved protein [Function unknown]; Region: COG1359 768490005963 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 768490005964 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 768490005965 homodimer interface [polypeptide binding]; other site 768490005966 oligonucleotide binding site [chemical binding]; other site 768490005967 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 768490005968 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 768490005969 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768490005970 RNA binding surface [nucleotide binding]; other site 768490005971 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 768490005972 active site 768490005973 Maf-like protein; Region: Maf; pfam02545 768490005974 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 768490005975 active site 768490005976 dimer interface [polypeptide binding]; other site 768490005977 hypothetical protein; Provisional; Region: PRK11193 768490005978 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 768490005979 putative phosphate acyltransferase; Provisional; Region: PRK05331 768490005980 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 768490005981 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 768490005982 dimer interface [polypeptide binding]; other site 768490005983 active site 768490005984 CoA binding pocket [chemical binding]; other site 768490005985 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 768490005986 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 768490005987 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 768490005988 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 768490005989 NAD(P) binding site [chemical binding]; other site 768490005990 homotetramer interface [polypeptide binding]; other site 768490005991 homodimer interface [polypeptide binding]; other site 768490005992 active site 768490005993 acyl carrier protein; Provisional; Region: acpP; PRK00982 768490005994 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 768490005995 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 768490005996 dimer interface [polypeptide binding]; other site 768490005997 active site 768490005998 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 768490005999 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 768490006000 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490006001 catalytic residue [active] 768490006002 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 768490006003 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 768490006004 dimerization interface [polypeptide binding]; other site 768490006005 thymidylate kinase; Validated; Region: tmk; PRK00698 768490006006 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 768490006007 TMP-binding site; other site 768490006008 ATP-binding site [chemical binding]; other site 768490006009 DNA polymerase III subunit delta'; Validated; Region: PRK07993 768490006010 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 768490006011 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 768490006012 active site 768490006013 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 768490006014 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768490006015 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768490006016 active site turn [active] 768490006017 phosphorylation site [posttranslational modification] 768490006018 manganese transport regulator MntR; Provisional; Region: PRK11050 768490006019 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768490006020 putative DNA binding site [nucleotide binding]; other site 768490006021 putative Zn2+ binding site [ion binding]; other site 768490006022 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 768490006023 manganese transport protein MntH; Reviewed; Region: PRK00701 768490006024 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 768490006025 Bacterial SH3 domain homologues; Region: SH3b; smart00287 768490006026 short chain dehydrogenase; Provisional; Region: PRK06500 768490006027 classical (c) SDRs; Region: SDR_c; cd05233 768490006028 NAD(P) binding site [chemical binding]; other site 768490006029 active site 768490006030 Predicted transcriptional regulators [Transcription]; Region: COG1733 768490006031 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 768490006032 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768490006033 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768490006034 substrate binding pocket [chemical binding]; other site 768490006035 membrane-bound complex binding site; other site 768490006036 hinge residues; other site 768490006037 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 768490006038 nucleotide binding site/active site [active] 768490006039 HIT family signature motif; other site 768490006040 catalytic residue [active] 768490006041 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 768490006042 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 768490006043 putative dimer interface [polypeptide binding]; other site 768490006044 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 768490006045 thiamine kinase; Region: ycfN_thiK; TIGR02721 768490006046 active site 768490006047 substrate binding site [chemical binding]; other site 768490006048 ATP binding site [chemical binding]; other site 768490006049 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 768490006050 beta-hexosaminidase; Provisional; Region: PRK05337 768490006051 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 768490006052 hypothetical protein; Provisional; Region: PRK04940 768490006053 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 768490006054 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768490006055 hypothetical protein; Provisional; Region: PRK11280 768490006056 Predicted transcriptional regulator [Transcription]; Region: COG1959 768490006057 Transcriptional regulator; Region: Rrf2; pfam02082 768490006058 Transcriptional regulator; Region: Rrf2; cl17282 768490006059 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 768490006060 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 768490006061 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768490006062 HlyD family secretion protein; Region: HlyD_3; pfam13437 768490006063 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 768490006064 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490006065 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490006066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490006067 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 768490006068 POT family; Region: PTR2; cl17359 768490006069 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 768490006070 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 768490006071 putative ligand binding site [chemical binding]; other site 768490006072 NAD binding site [chemical binding]; other site 768490006073 dimerization interface [polypeptide binding]; other site 768490006074 catalytic site [active] 768490006075 putative hydrolase; Validated; Region: PRK09248 768490006076 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 768490006077 active site 768490006078 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 768490006079 Protein of unknown function (DUF533); Region: DUF533; pfam04391 768490006080 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 768490006081 putative metal binding site [ion binding]; other site 768490006082 protease 2; Provisional; Region: PRK10115 768490006083 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 768490006084 exodeoxyribonuclease X; Provisional; Region: PRK07983 768490006085 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 768490006086 active site 768490006087 catalytic site [active] 768490006088 substrate binding site [chemical binding]; other site 768490006089 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 768490006090 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 768490006091 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 768490006092 CopC domain; Region: CopC; cl01012 768490006093 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 768490006094 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 768490006095 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768490006096 Isochorismatase family; Region: Isochorismatase; pfam00857 768490006097 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 768490006098 catalytic triad [active] 768490006099 conserved cis-peptide bond; other site 768490006100 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 768490006101 putative transposase OrfB; Reviewed; Region: PHA02517 768490006102 Integrase core domain; Region: rve; pfam00665 768490006103 Integrase core domain; Region: rve_3; pfam13683 768490006104 Homeodomain-like domain; Region: HTH_23; cl17451 768490006105 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 768490006106 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 768490006107 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 768490006108 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 768490006109 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 768490006110 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768490006111 salt bridge; other site 768490006112 non-specific DNA binding site [nucleotide binding]; other site 768490006113 sequence-specific DNA binding site [nucleotide binding]; other site 768490006114 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490006115 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490006116 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768490006117 dimerization interface [polypeptide binding]; other site 768490006118 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 768490006119 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 768490006120 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490006121 active site 768490006122 phosphorylation site [posttranslational modification] 768490006123 intermolecular recognition site; other site 768490006124 dimerization interface [polypeptide binding]; other site 768490006125 sensory histidine kinase DcuS; Provisional; Region: PRK11086 768490006126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490006127 ATP binding site [chemical binding]; other site 768490006128 Mg2+ binding site [ion binding]; other site 768490006129 G-X-G motif; other site 768490006130 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 768490006131 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 768490006132 putative active site; other site 768490006133 catalytic residue [active] 768490006134 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 768490006135 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 768490006136 putative ligand binding site [chemical binding]; other site 768490006137 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 768490006138 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768490006139 Walker A/P-loop; other site 768490006140 ATP binding site [chemical binding]; other site 768490006141 Q-loop/lid; other site 768490006142 ABC transporter signature motif; other site 768490006143 Walker B; other site 768490006144 D-loop; other site 768490006145 H-loop/switch region; other site 768490006146 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768490006147 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768490006148 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768490006149 TM-ABC transporter signature motif; other site 768490006150 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 768490006151 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 768490006152 putative ligand binding site [chemical binding]; other site 768490006153 Right handed beta helix region; Region: Beta_helix; pfam13229 768490006154 Right handed beta helix region; Region: Beta_helix; pfam13229 768490006155 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 768490006156 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 768490006157 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 768490006158 Ligand Binding Site [chemical binding]; other site 768490006159 putative kinase; Provisional; Region: PRK09954 768490006160 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768490006161 putative DNA binding site [nucleotide binding]; other site 768490006162 putative Zn2+ binding site [ion binding]; other site 768490006163 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 768490006164 substrate binding site [chemical binding]; other site 768490006165 ATP binding site [chemical binding]; other site 768490006166 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 768490006167 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 768490006168 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 768490006169 Nucleoside recognition; Region: Gate; pfam07670 768490006170 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 768490006171 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 768490006172 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768490006173 dimerization interface [polypeptide binding]; other site 768490006174 putative DNA binding site [nucleotide binding]; other site 768490006175 putative Zn2+ binding site [ion binding]; other site 768490006176 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 768490006177 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 768490006178 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 768490006179 oligomer interface [polypeptide binding]; other site 768490006180 active site residues [active] 768490006181 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768490006182 PAS domain; Region: PAS_9; pfam13426 768490006183 putative active site [active] 768490006184 heme pocket [chemical binding]; other site 768490006185 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768490006186 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768490006187 metal binding site [ion binding]; metal-binding site 768490006188 active site 768490006189 I-site; other site 768490006190 GTP-binding protein YchF; Reviewed; Region: PRK09601 768490006191 YchF GTPase; Region: YchF; cd01900 768490006192 G1 box; other site 768490006193 GTP/Mg2+ binding site [chemical binding]; other site 768490006194 Switch I region; other site 768490006195 G2 box; other site 768490006196 Switch II region; other site 768490006197 G3 box; other site 768490006198 G4 box; other site 768490006199 G5 box; other site 768490006200 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 768490006201 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 768490006202 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 768490006203 Sulfate transporter family; Region: Sulfate_transp; pfam00916 768490006204 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 768490006205 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 768490006206 putative active site [active] 768490006207 catalytic residue [active] 768490006208 hypothetical protein; Provisional; Region: PRK10692 768490006209 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 768490006210 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 768490006211 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768490006212 active site 768490006213 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 768490006214 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 768490006215 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 768490006216 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 768490006217 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 768490006218 Chitin binding domain; Region: Chitin_bind_3; cl03871 768490006219 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 768490006220 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 768490006221 tRNA; other site 768490006222 putative tRNA binding site [nucleotide binding]; other site 768490006223 putative NADP binding site [chemical binding]; other site 768490006224 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 768490006225 peptide chain release factor 1; Validated; Region: prfA; PRK00591 768490006226 This domain is found in peptide chain release factors; Region: PCRF; smart00937 768490006227 RF-1 domain; Region: RF-1; pfam00472 768490006228 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 768490006229 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490006230 Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247 768490006231 hypothetical protein; Provisional; Region: PRK10941 768490006232 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 768490006233 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 768490006234 TPR motif; other site 768490006235 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 768490006236 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 768490006237 putative transporter; Provisional; Region: PRK11660 768490006238 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 768490006239 Sulfate transporter family; Region: Sulfate_transp; pfam00916 768490006240 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 768490006241 hypothetical protein; Provisional; Region: PRK02487 768490006242 transcription-repair coupling factor; Provisional; Region: PRK10689 768490006243 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 768490006244 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768490006245 ATP binding site [chemical binding]; other site 768490006246 putative Mg++ binding site [ion binding]; other site 768490006247 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768490006248 nucleotide binding region [chemical binding]; other site 768490006249 ATP-binding site [chemical binding]; other site 768490006250 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 768490006251 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 768490006252 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 768490006253 tetramer interface [polypeptide binding]; other site 768490006254 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490006255 catalytic residue [active] 768490006256 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 768490006257 YheO-like PAS domain; Region: PAS_6; pfam08348 768490006258 HTH domain; Region: HTH_22; pfam13309 768490006259 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 768490006260 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768490006261 FtsX-like permease family; Region: FtsX; pfam02687 768490006262 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 768490006263 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768490006264 Walker A/P-loop; other site 768490006265 ATP binding site [chemical binding]; other site 768490006266 Q-loop/lid; other site 768490006267 ABC transporter signature motif; other site 768490006268 Walker B; other site 768490006269 D-loop; other site 768490006270 H-loop/switch region; other site 768490006271 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 768490006272 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768490006273 FtsX-like permease family; Region: FtsX; pfam02687 768490006274 fructokinase; Reviewed; Region: PRK09557 768490006275 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768490006276 nucleotide binding site [chemical binding]; other site 768490006277 NAD-dependent deacetylase; Provisional; Region: PRK00481 768490006278 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 768490006279 NAD+ binding site [chemical binding]; other site 768490006280 substrate binding site [chemical binding]; other site 768490006281 Zn binding site [ion binding]; other site 768490006282 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 768490006283 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768490006284 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768490006285 putative active site [active] 768490006286 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 768490006287 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 768490006288 NAD(P) binding site [chemical binding]; other site 768490006289 LDH/MDH dimer interface [polypeptide binding]; other site 768490006290 substrate binding site [chemical binding]; other site 768490006291 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768490006292 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 768490006293 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768490006294 active site turn [active] 768490006295 phosphorylation site [posttranslational modification] 768490006296 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 768490006297 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 768490006298 metal binding site [ion binding]; metal-binding site 768490006299 dimer interface [polypeptide binding]; other site 768490006300 putative dehydrogenase; Provisional; Region: PRK10098 768490006301 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 768490006302 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768490006303 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490006304 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768490006305 dimerization interface [polypeptide binding]; other site 768490006306 Uncharacterized conserved protein [Function unknown]; Region: COG2850 768490006307 Cupin domain; Region: Cupin_2; cl17218 768490006308 sensor protein PhoQ; Provisional; Region: PRK10815 768490006309 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 768490006310 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 768490006311 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490006312 ATP binding site [chemical binding]; other site 768490006313 Mg2+ binding site [ion binding]; other site 768490006314 G-X-G motif; other site 768490006315 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 768490006316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490006317 active site 768490006318 phosphorylation site [posttranslational modification] 768490006319 intermolecular recognition site; other site 768490006320 dimerization interface [polypeptide binding]; other site 768490006321 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768490006322 DNA binding site [nucleotide binding] 768490006323 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768490006324 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768490006325 DNA-binding site [nucleotide binding]; DNA binding site 768490006326 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768490006327 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490006328 homodimer interface [polypeptide binding]; other site 768490006329 catalytic residue [active] 768490006330 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768490006331 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490006332 Coenzyme A binding pocket [chemical binding]; other site 768490006333 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 768490006334 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768490006335 adenylosuccinate lyase; Provisional; Region: PRK09285 768490006336 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 768490006337 tetramer interface [polypeptide binding]; other site 768490006338 active site 768490006339 putative lysogenization regulator; Reviewed; Region: PRK00218 768490006340 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 768490006341 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 768490006342 Ligand Binding Site [chemical binding]; other site 768490006343 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 768490006344 nudix motif; other site 768490006345 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 768490006346 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 768490006347 probable active site [active] 768490006348 isocitrate dehydrogenase; Validated; Region: PRK07362 768490006349 isocitrate dehydrogenase; Reviewed; Region: PRK07006 768490006350 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 768490006351 Autoinducer binding domain; Region: Autoind_bind; pfam03472 768490006352 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768490006353 DNA binding residues [nucleotide binding] 768490006354 dimerization interface [polypeptide binding]; other site 768490006355 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 768490006356 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 768490006357 TolA C-terminal; Region: TolA; pfam06519 768490006358 Domain of unknown function DUF20; Region: UPF0118; pfam01594 768490006359 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 768490006360 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490006361 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768490006362 Coenzyme A binding pocket [chemical binding]; other site 768490006363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490006364 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768490006365 putative substrate translocation pore; other site 768490006366 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 768490006367 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768490006368 DNA binding site [nucleotide binding] 768490006369 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 768490006370 putative ligand binding site [chemical binding]; other site 768490006371 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 768490006372 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768490006373 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768490006374 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 768490006375 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 768490006376 Protein of unknown function; Region: DUF3658; pfam12395 768490006377 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 768490006378 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 768490006379 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 768490006380 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 768490006381 LysE type translocator; Region: LysE; cl00565 768490006382 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768490006383 DNA-binding site [nucleotide binding]; DNA binding site 768490006384 RNA-binding motif; other site 768490006385 short chain dehydrogenase; Provisional; Region: PRK06138 768490006386 classical (c) SDRs; Region: SDR_c; cd05233 768490006387 NAD(P) binding site [chemical binding]; other site 768490006388 active site 768490006389 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 768490006390 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 768490006391 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 768490006392 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 768490006393 NAD(P) binding site [chemical binding]; other site 768490006394 catalytic residues [active] 768490006395 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 768490006396 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768490006397 non-specific DNA binding site [nucleotide binding]; other site 768490006398 salt bridge; other site 768490006399 sequence-specific DNA binding site [nucleotide binding]; other site 768490006400 Cupin domain; Region: Cupin_2; pfam07883 768490006401 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 768490006402 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 768490006403 catalytic triad [active] 768490006404 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 768490006405 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 768490006406 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 768490006407 aromatic amino acid exporter; Provisional; Region: PRK11689 768490006408 EamA-like transporter family; Region: EamA; pfam00892 768490006409 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 768490006410 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 768490006411 chorismate mutase; Provisional; Region: PRK08055 768490006412 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 768490006413 Beta-lactamase; Region: Beta-lactamase; pfam00144 768490006414 N-formylglutamate amidohydrolase; Region: FGase; cl01522 768490006415 imidazolonepropionase; Validated; Region: PRK09356 768490006416 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 768490006417 active site 768490006418 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 768490006419 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768490006420 DNA-binding site [nucleotide binding]; DNA binding site 768490006421 UTRA domain; Region: UTRA; pfam07702 768490006422 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 768490006423 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 768490006424 active site 768490006425 HutD; Region: HutD; pfam05962 768490006426 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 768490006427 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 768490006428 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 768490006429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490006430 dimer interface [polypeptide binding]; other site 768490006431 conserved gate region; other site 768490006432 putative PBP binding loops; other site 768490006433 ABC-ATPase subunit interface; other site 768490006434 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 768490006435 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 768490006436 Walker A/P-loop; other site 768490006437 ATP binding site [chemical binding]; other site 768490006438 Q-loop/lid; other site 768490006439 ABC transporter signature motif; other site 768490006440 Walker B; other site 768490006441 D-loop; other site 768490006442 H-loop/switch region; other site 768490006443 histidinol-phosphate aminotransferase; Provisional; Region: PRK05166 768490006444 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768490006445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490006446 homodimer interface [polypeptide binding]; other site 768490006447 catalytic residue [active] 768490006448 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 768490006449 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 768490006450 phosphate binding site [ion binding]; other site 768490006451 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768490006452 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768490006453 DNA binding site [nucleotide binding] 768490006454 domain linker motif; other site 768490006455 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 768490006456 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 768490006457 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 768490006458 substrate binding [chemical binding]; other site 768490006459 active site 768490006460 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 768490006461 galactoside permease; Reviewed; Region: lacY; PRK09528 768490006462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490006463 putative substrate translocation pore; other site 768490006464 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768490006465 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 768490006466 NAD(P) binding site [chemical binding]; other site 768490006467 active site 768490006468 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 768490006469 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 768490006470 NAD binding site [chemical binding]; other site 768490006471 dimerization interface [polypeptide binding]; other site 768490006472 product binding site; other site 768490006473 substrate binding site [chemical binding]; other site 768490006474 zinc binding site [ion binding]; other site 768490006475 catalytic residues [active] 768490006476 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 768490006477 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 768490006478 Walker A/P-loop; other site 768490006479 ATP binding site [chemical binding]; other site 768490006480 Q-loop/lid; other site 768490006481 ABC transporter signature motif; other site 768490006482 Walker B; other site 768490006483 D-loop; other site 768490006484 H-loop/switch region; other site 768490006485 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 768490006486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490006487 dimer interface [polypeptide binding]; other site 768490006488 conserved gate region; other site 768490006489 putative PBP binding loops; other site 768490006490 ABC-ATPase subunit interface; other site 768490006491 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 768490006492 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768490006493 substrate binding pocket [chemical binding]; other site 768490006494 membrane-bound complex binding site; other site 768490006495 hinge residues; other site 768490006496 metabolite-proton symporter; Region: 2A0106; TIGR00883 768490006497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490006498 putative substrate translocation pore; other site 768490006499 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768490006500 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768490006501 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490006502 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490006503 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 768490006504 putative effector binding pocket; other site 768490006505 putative dimerization interface [polypeptide binding]; other site 768490006506 hypothetical protein; Provisional; Region: PRK08204 768490006507 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 768490006508 active site 768490006509 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 768490006510 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 768490006511 active site 768490006512 substrate-binding site [chemical binding]; other site 768490006513 metal-binding site [ion binding] 768490006514 ATP binding site [chemical binding]; other site 768490006515 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 768490006516 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 768490006517 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 768490006518 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 768490006519 Spore Coat Protein U domain; Region: SCPU; pfam05229 768490006520 Uncharacterized secreted protein [Function unknown]; Region: COG5430 768490006521 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 768490006522 PapC N-terminal domain; Region: PapC_N; pfam13954 768490006523 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 768490006524 PapC C-terminal domain; Region: PapC_C; pfam13953 768490006525 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 768490006526 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 768490006527 Spore Coat Protein U domain; Region: SCPU; pfam05229 768490006528 Spore Coat Protein U domain; Region: SCPU; pfam05229 768490006529 Spore Coat Protein U domain; Region: SCPU; pfam05229 768490006530 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 768490006531 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490006532 S-adenosylmethionine binding site [chemical binding]; other site 768490006533 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 768490006534 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 768490006535 mce related protein; Region: MCE; pfam02470 768490006536 mce related protein; Region: MCE; pfam02470 768490006537 mce related protein; Region: MCE; pfam02470 768490006538 mce related protein; Region: MCE; pfam02470 768490006539 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 768490006540 mce related protein; Region: MCE; pfam02470 768490006541 mce related protein; Region: MCE; pfam02470 768490006542 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 768490006543 Paraquat-inducible protein A; Region: PqiA; pfam04403 768490006544 Paraquat-inducible protein A; Region: PqiA; pfam04403 768490006545 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 768490006546 GAF domain; Region: GAF_2; pfam13185 768490006547 ProP expression regulator; Provisional; Region: PRK04950 768490006548 ProQ/FINO family; Region: ProQ; pfam04352 768490006549 putative RNA binding sites [nucleotide binding]; other site 768490006550 carboxy-terminal protease; Provisional; Region: PRK11186 768490006551 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 768490006552 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 768490006553 protein binding site [polypeptide binding]; other site 768490006554 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 768490006555 Catalytic dyad [active] 768490006556 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 768490006557 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 768490006558 heat shock protein HtpX; Provisional; Region: PRK05457 768490006559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490006560 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768490006561 putative substrate translocation pore; other site 768490006562 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 768490006563 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 768490006564 Bacterial transcriptional regulator; Region: IclR; pfam01614 768490006565 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 768490006566 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 768490006567 inner membrane protein; Provisional; Region: PRK11648 768490006568 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 768490006569 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768490006570 motif II; other site 768490006571 YniB-like protein; Region: YniB; pfam14002 768490006572 Fructosamine kinase; Region: Fructosamin_kin; pfam03881 768490006573 Phosphotransferase enzyme family; Region: APH; pfam01636 768490006574 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490006575 Coenzyme A binding pocket [chemical binding]; other site 768490006576 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 768490006577 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768490006578 ABC-ATPase subunit interface; other site 768490006579 dimer interface [polypeptide binding]; other site 768490006580 putative PBP binding regions; other site 768490006581 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 768490006582 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768490006583 ABC-ATPase subunit interface; other site 768490006584 dimer interface [polypeptide binding]; other site 768490006585 putative PBP binding regions; other site 768490006586 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 768490006587 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 768490006588 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 768490006589 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 768490006590 metal binding site [ion binding]; metal-binding site 768490006591 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 768490006592 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 768490006593 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768490006594 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768490006595 catalytic residue [active] 768490006596 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 768490006597 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 768490006598 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 768490006599 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 768490006600 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768490006601 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768490006602 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 768490006603 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 768490006604 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 768490006605 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 768490006606 intersubunit interface [polypeptide binding]; other site 768490006607 inner membrane protein; Provisional; Region: PRK10995 768490006608 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 768490006609 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 768490006610 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 768490006611 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 768490006612 active site 768490006613 dimer interface [polypeptide binding]; other site 768490006614 motif 1; other site 768490006615 motif 2; other site 768490006616 motif 3; other site 768490006617 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 768490006618 anticodon binding site; other site 768490006619 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 768490006620 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 768490006621 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 768490006622 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 768490006623 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 768490006624 23S rRNA binding site [nucleotide binding]; other site 768490006625 L21 binding site [polypeptide binding]; other site 768490006626 L13 binding site [polypeptide binding]; other site 768490006627 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 768490006628 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 768490006629 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 768490006630 dimer interface [polypeptide binding]; other site 768490006631 motif 1; other site 768490006632 active site 768490006633 motif 2; other site 768490006634 motif 3; other site 768490006635 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 768490006636 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 768490006637 putative tRNA-binding site [nucleotide binding]; other site 768490006638 B3/4 domain; Region: B3_4; pfam03483 768490006639 tRNA synthetase B5 domain; Region: B5; smart00874 768490006640 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 768490006641 dimer interface [polypeptide binding]; other site 768490006642 motif 1; other site 768490006643 motif 3; other site 768490006644 motif 2; other site 768490006645 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 768490006646 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 768490006647 IHF dimer interface [polypeptide binding]; other site 768490006648 IHF - DNA interface [nucleotide binding]; other site 768490006649 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 768490006650 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 768490006651 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768490006652 dimer interface [polypeptide binding]; other site 768490006653 putative PBP binding regions; other site 768490006654 ABC-ATPase subunit interface; other site 768490006655 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 768490006656 catalytic residues [active] 768490006657 dimer interface [polypeptide binding]; other site 768490006658 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 768490006659 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768490006660 Walker A/P-loop; other site 768490006661 ATP binding site [chemical binding]; other site 768490006662 Q-loop/lid; other site 768490006663 ABC transporter signature motif; other site 768490006664 Walker B; other site 768490006665 D-loop; other site 768490006666 H-loop/switch region; other site 768490006667 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 768490006668 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 768490006669 inhibitor-cofactor binding pocket; inhibition site 768490006670 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490006671 catalytic residue [active] 768490006672 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 768490006673 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 768490006674 Ligand binding site; other site 768490006675 Putative Catalytic site; other site 768490006676 DXD motif; other site 768490006677 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 768490006678 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 768490006679 active site 768490006680 substrate binding site [chemical binding]; other site 768490006681 cosubstrate binding site; other site 768490006682 catalytic site [active] 768490006683 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 768490006684 active site 768490006685 hexamer interface [polypeptide binding]; other site 768490006686 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 768490006687 NAD binding site [chemical binding]; other site 768490006688 substrate binding site [chemical binding]; other site 768490006689 active site 768490006690 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 768490006691 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 768490006692 putative active site [active] 768490006693 putative catalytic site [active] 768490006694 putative Zn binding site [ion binding]; other site 768490006695 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 768490006696 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 768490006697 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 768490006698 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 768490006699 NlpC/P60 family; Region: NLPC_P60; pfam00877 768490006700 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 768490006701 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 768490006702 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 768490006703 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768490006704 Uncharacterized conserved protein [Function unknown]; Region: COG0397 768490006705 hypothetical protein; Validated; Region: PRK00029 768490006706 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 768490006707 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768490006708 Walker A/P-loop; other site 768490006709 ATP binding site [chemical binding]; other site 768490006710 Q-loop/lid; other site 768490006711 ABC transporter signature motif; other site 768490006712 Walker B; other site 768490006713 D-loop; other site 768490006714 H-loop/switch region; other site 768490006715 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 768490006716 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768490006717 ABC-ATPase subunit interface; other site 768490006718 dimer interface [polypeptide binding]; other site 768490006719 putative PBP binding regions; other site 768490006720 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 768490006721 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 768490006722 putative hemin binding site; other site 768490006723 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 768490006724 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 768490006725 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 768490006726 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 768490006727 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768490006728 N-terminal plug; other site 768490006729 ligand-binding site [chemical binding]; other site 768490006730 Hemin uptake protein hemP; Region: hemP; pfam10636 768490006731 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 768490006732 catalytic residues [active] 768490006733 dimer interface [polypeptide binding]; other site 768490006734 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 768490006735 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 768490006736 PEP synthetase regulatory protein; Provisional; Region: PRK05339 768490006737 phosphoenolpyruvate synthase; Validated; Region: PRK06464 768490006738 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 768490006739 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 768490006740 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 768490006741 putative inner membrane protein; Provisional; Region: PRK10983 768490006742 Domain of unknown function DUF20; Region: UPF0118; pfam01594 768490006743 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 768490006744 FAD binding domain; Region: FAD_binding_4; pfam01565 768490006745 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 768490006746 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 768490006747 CoenzymeA binding site [chemical binding]; other site 768490006748 subunit interaction site [polypeptide binding]; other site 768490006749 PHB binding site; other site 768490006750 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 768490006751 putative ABC transporter; Region: ycf24; CHL00085 768490006752 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 768490006753 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 768490006754 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 768490006755 Walker A/P-loop; other site 768490006756 ATP binding site [chemical binding]; other site 768490006757 Q-loop/lid; other site 768490006758 ABC transporter signature motif; other site 768490006759 Walker B; other site 768490006760 D-loop; other site 768490006761 H-loop/switch region; other site 768490006762 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 768490006763 FeS assembly protein SufD; Region: sufD; TIGR01981 768490006764 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 768490006765 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 768490006766 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768490006767 catalytic residue [active] 768490006768 cysteine desufuration protein SufE; Provisional; Region: PRK09296 768490006769 L,D-transpeptidase; Provisional; Region: PRK10190 768490006770 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768490006771 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 768490006772 murein lipoprotein; Provisional; Region: PRK15396 768490006773 pyruvate kinase; Provisional; Region: PRK09206 768490006774 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 768490006775 domain interfaces; other site 768490006776 active site 768490006777 Cupin domain; Region: Cupin_2; cl17218 768490006778 multidrug efflux protein; Reviewed; Region: PRK01766 768490006779 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 768490006780 cation binding site [ion binding]; other site 768490006781 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 768490006782 Lumazine binding domain; Region: Lum_binding; pfam00677 768490006783 Lumazine binding domain; Region: Lum_binding; pfam00677 768490006784 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 768490006785 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 768490006786 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 768490006787 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490006788 S-adenosylmethionine binding site [chemical binding]; other site 768490006789 putative transporter; Provisional; Region: PRK11043 768490006790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490006791 putative substrate translocation pore; other site 768490006792 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 768490006793 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490006794 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768490006795 dimerization interface [polypeptide binding]; other site 768490006796 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 768490006797 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768490006798 DNA binding site [nucleotide binding] 768490006799 domain linker motif; other site 768490006800 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 768490006801 dimerization interface [polypeptide binding]; other site 768490006802 ligand binding site [chemical binding]; other site 768490006803 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 768490006804 NlpC/P60 family; Region: NLPC_P60; pfam00877 768490006805 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 768490006806 putative GSH binding site [chemical binding]; other site 768490006807 catalytic residues [active] 768490006808 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 768490006809 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 768490006810 dimer interface [polypeptide binding]; other site 768490006811 catalytic site [active] 768490006812 putative active site [active] 768490006813 putative substrate binding site [chemical binding]; other site 768490006814 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768490006815 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 768490006816 dimer interface [polypeptide binding]; other site 768490006817 active site 768490006818 metal binding site [ion binding]; metal-binding site 768490006819 glutathione binding site [chemical binding]; other site 768490006820 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 768490006821 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 768490006822 active site 768490006823 metal binding site [ion binding]; metal-binding site 768490006824 nudix motif; other site 768490006825 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 768490006826 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 768490006827 FMN binding site [chemical binding]; other site 768490006828 active site 768490006829 substrate binding site [chemical binding]; other site 768490006830 catalytic residue [active] 768490006831 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768490006832 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768490006833 putative metal dependent hydrolase; Provisional; Region: PRK11598 768490006834 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 768490006835 Sulfatase; Region: Sulfatase; pfam00884 768490006836 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 768490006837 NADH(P)-binding; Region: NAD_binding_10; pfam13460 768490006838 NAD binding site [chemical binding]; other site 768490006839 substrate binding site [chemical binding]; other site 768490006840 putative active site [active] 768490006841 transcriptional regulator; Provisional; Region: PRK10632 768490006842 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490006843 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768490006844 putative effector binding pocket; other site 768490006845 dimerization interface [polypeptide binding]; other site 768490006846 Predicted Fe-S protein [General function prediction only]; Region: COG3313 768490006847 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768490006848 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768490006849 active site 768490006850 catalytic tetrad [active] 768490006851 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 768490006852 nucleophilic elbow; other site 768490006853 catalytic triad; other site 768490006854 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 768490006855 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 768490006856 E-class dimer interface [polypeptide binding]; other site 768490006857 P-class dimer interface [polypeptide binding]; other site 768490006858 active site 768490006859 Cu2+ binding site [ion binding]; other site 768490006860 Zn2+ binding site [ion binding]; other site 768490006861 Fusaric acid resistance protein family; Region: FUSC; pfam04632 768490006862 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 768490006863 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 768490006864 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768490006865 HlyD family secretion protein; Region: HlyD_3; pfam13437 768490006866 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 768490006867 transcriptional regulator SlyA; Provisional; Region: PRK03573 768490006868 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 768490006869 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 768490006870 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 768490006871 lysozyme inhibitor; Provisional; Region: PRK11372 768490006872 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 768490006873 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 768490006874 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 768490006875 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 768490006876 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 768490006877 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 768490006878 active site 768490006879 HIGH motif; other site 768490006880 dimer interface [polypeptide binding]; other site 768490006881 KMSKS motif; other site 768490006882 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768490006883 RNA binding surface [nucleotide binding]; other site 768490006884 pyridoxamine kinase; Validated; Region: PRK05756 768490006885 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 768490006886 dimer interface [polypeptide binding]; other site 768490006887 pyridoxal binding site [chemical binding]; other site 768490006888 ATP binding site [chemical binding]; other site 768490006889 glutathionine S-transferase; Provisional; Region: PRK10542 768490006890 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 768490006891 C-terminal domain interface [polypeptide binding]; other site 768490006892 GSH binding site (G-site) [chemical binding]; other site 768490006893 dimer interface [polypeptide binding]; other site 768490006894 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 768490006895 dimer interface [polypeptide binding]; other site 768490006896 N-terminal domain interface [polypeptide binding]; other site 768490006897 substrate binding pocket (H-site) [chemical binding]; other site 768490006898 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 768490006899 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 768490006900 dimer interface [polypeptide binding]; other site 768490006901 active site 768490006902 catalytic residue [active] 768490006903 YjbD family (DUF3811); Region: DUF3811; pfam11656 768490006904 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 768490006905 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768490006906 Zn2+ binding site [ion binding]; other site 768490006907 Mg2+ binding site [ion binding]; other site 768490006908 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 768490006909 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 768490006910 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 768490006911 homotrimer interaction site [polypeptide binding]; other site 768490006912 putative active site [active] 768490006913 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 768490006914 Cupin domain; Region: Cupin_2; cl17218 768490006915 MEKHLA domain; Region: MEKHLA; pfam08670 768490006916 benzoate transporter; Region: benE; TIGR00843 768490006917 Benzoate membrane transport protein; Region: BenE; pfam03594 768490006918 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 768490006919 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768490006920 non-specific DNA binding site [nucleotide binding]; other site 768490006921 salt bridge; other site 768490006922 sequence-specific DNA binding site [nucleotide binding]; other site 768490006923 Cupin domain; Region: Cupin_2; pfam07883 768490006924 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 768490006925 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 768490006926 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 768490006927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490006928 putative substrate translocation pore; other site 768490006929 POT family; Region: PTR2; pfam00854 768490006930 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 768490006931 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 768490006932 putative symporter YagG; Provisional; Region: PRK09669 768490006933 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768490006934 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490006935 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490006936 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768490006937 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490006938 putative symporter YagG; Provisional; Region: PRK09669 768490006939 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 768490006940 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 768490006941 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 768490006942 inhibitor binding site; inhibition site 768490006943 active site 768490006944 endonuclease III; Provisional; Region: PRK10702 768490006945 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 768490006946 minor groove reading motif; other site 768490006947 helix-hairpin-helix signature motif; other site 768490006948 substrate binding pocket [chemical binding]; other site 768490006949 active site 768490006950 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 768490006951 electron transport complex RsxE subunit; Provisional; Region: PRK12405 768490006952 electron transport complex protein RnfG; Validated; Region: PRK01908 768490006953 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 768490006954 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 768490006955 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490006956 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 768490006957 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 768490006958 SLBB domain; Region: SLBB; pfam10531 768490006959 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768490006960 ferredoxin; Provisional; Region: PRK08764 768490006961 Putative Fe-S cluster; Region: FeS; cl17515 768490006962 4Fe-4S binding domain; Region: Fer4; pfam00037 768490006963 electron transport complex protein RsxA; Provisional; Region: PRK05151 768490006964 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 768490006965 L-arabinose isomerase; Provisional; Region: PRK02929 768490006966 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 768490006967 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 768490006968 trimer interface [polypeptide binding]; other site 768490006969 putative substrate binding site [chemical binding]; other site 768490006970 putative metal binding site [ion binding]; other site 768490006971 ribulokinase; Provisional; Region: PRK04123 768490006972 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 768490006973 N- and C-terminal domain interface [polypeptide binding]; other site 768490006974 active site 768490006975 MgATP binding site [chemical binding]; other site 768490006976 catalytic site [active] 768490006977 metal binding site [ion binding]; metal-binding site 768490006978 carbohydrate binding site [chemical binding]; other site 768490006979 homodimer interface [polypeptide binding]; other site 768490006980 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 768490006981 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 768490006982 ligand binding site [chemical binding]; other site 768490006983 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 768490006984 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768490006985 Walker A/P-loop; other site 768490006986 ATP binding site [chemical binding]; other site 768490006987 Q-loop/lid; other site 768490006988 ABC transporter signature motif; other site 768490006989 Walker B; other site 768490006990 D-loop; other site 768490006991 H-loop/switch region; other site 768490006992 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768490006993 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768490006994 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768490006995 TM-ABC transporter signature motif; other site 768490006996 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 768490006997 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768490006998 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490006999 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490007000 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 768490007001 substrate binding pocket [chemical binding]; other site 768490007002 substrate-Mg2+ binding site; other site 768490007003 aspartate-rich region 1; other site 768490007004 aspartate-rich region 2; other site 768490007005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490007006 S-adenosylmethionine binding site [chemical binding]; other site 768490007007 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 768490007008 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 768490007009 TPP-binding site; other site 768490007010 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 768490007011 PYR/PP interface [polypeptide binding]; other site 768490007012 dimer interface [polypeptide binding]; other site 768490007013 TPP binding site [chemical binding]; other site 768490007014 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768490007015 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 768490007016 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 768490007017 active site 768490007018 metal binding site [ion binding]; metal-binding site 768490007019 nudix motif; other site 768490007020 putative oxidoreductase; Provisional; Region: PRK11579 768490007021 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768490007022 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 768490007023 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 768490007024 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 768490007025 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 768490007026 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 768490007027 active site 768490007028 purine riboside binding site [chemical binding]; other site 768490007029 AAA domain; Region: AAA_17; pfam13207 768490007030 AAA domain; Region: AAA_18; pfam13238 768490007031 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 768490007032 active site 768490007033 phosphorylation site [posttranslational modification] 768490007034 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 768490007035 intersubunit interface [polypeptide binding]; other site 768490007036 active site 768490007037 zinc binding site [ion binding]; other site 768490007038 Na+ binding site [ion binding]; other site 768490007039 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 768490007040 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 768490007041 active site 768490007042 P-loop; other site 768490007043 phosphorylation site [posttranslational modification] 768490007044 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 768490007045 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 768490007046 active site 768490007047 ADP/pyrophosphate binding site [chemical binding]; other site 768490007048 dimerization interface [polypeptide binding]; other site 768490007049 allosteric effector site; other site 768490007050 fructose-1,6-bisphosphate binding site; other site 768490007051 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 768490007052 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 768490007053 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 768490007054 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 768490007055 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 768490007056 dimer interface [polypeptide binding]; other site 768490007057 ADP-ribose binding site [chemical binding]; other site 768490007058 active site 768490007059 nudix motif; other site 768490007060 metal binding site [ion binding]; metal-binding site 768490007061 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 768490007062 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 768490007063 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768490007064 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490007065 homodimer interface [polypeptide binding]; other site 768490007066 catalytic residue [active] 768490007067 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 768490007068 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 768490007069 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768490007070 active site turn [active] 768490007071 phosphorylation site [posttranslational modification] 768490007072 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 768490007073 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768490007074 DNA binding site [nucleotide binding] 768490007075 domain linker motif; other site 768490007076 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 768490007077 putative dimerization interface [polypeptide binding]; other site 768490007078 putative ligand binding site [chemical binding]; other site 768490007079 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768490007080 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490007081 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768490007082 dimerization interface [polypeptide binding]; other site 768490007083 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 768490007084 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 768490007085 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490007086 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490007087 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 768490007088 putative effector binding pocket; other site 768490007089 putative dimerization interface [polypeptide binding]; other site 768490007090 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 768490007091 Beta-lactamase; Region: Beta-lactamase; pfam00144 768490007092 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 768490007093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 768490007094 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 768490007095 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 768490007096 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 768490007097 fumarate hydratase; Reviewed; Region: fumC; PRK00485 768490007098 Class II fumarases; Region: Fumarase_classII; cd01362 768490007099 active site 768490007100 tetramer interface [polypeptide binding]; other site 768490007101 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 768490007102 putative catalytic residues [active] 768490007103 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490007104 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490007105 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768490007106 putative effector binding pocket; other site 768490007107 dimerization interface [polypeptide binding]; other site 768490007108 Predicted transcriptional regulator [Transcription]; Region: COG2378 768490007109 HTH domain; Region: HTH_11; pfam08279 768490007110 WYL domain; Region: WYL; pfam13280 768490007111 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768490007112 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 768490007113 putative dimer interface [polypeptide binding]; other site 768490007114 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 768490007115 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768490007116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490007117 putative substrate translocation pore; other site 768490007118 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 768490007119 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490007120 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 768490007121 dimerization interface [polypeptide binding]; other site 768490007122 substrate binding pocket [chemical binding]; other site 768490007123 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 768490007124 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 768490007125 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768490007126 nucleotide binding site [chemical binding]; other site 768490007127 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 768490007128 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 768490007129 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 768490007130 Cl- selectivity filter; other site 768490007131 Cl- binding residues [ion binding]; other site 768490007132 pore gating glutamate residue; other site 768490007133 dimer interface [polypeptide binding]; other site 768490007134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490007135 putative substrate translocation pore; other site 768490007136 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 768490007137 hypothetical protein; Provisional; Region: PRK13659 768490007138 hypothetical protein; Provisional; Region: PRK02237 768490007139 malonic semialdehyde reductase; Provisional; Region: PRK10538 768490007140 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 768490007141 putative NAD(P) binding site [chemical binding]; other site 768490007142 homodimer interface [polypeptide binding]; other site 768490007143 homotetramer interface [polypeptide binding]; other site 768490007144 active site 768490007145 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768490007146 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 768490007147 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768490007148 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768490007149 active site 768490007150 catalytic tetrad [active] 768490007151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490007152 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768490007153 putative substrate translocation pore; other site 768490007154 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 768490007155 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768490007156 Walker A/P-loop; other site 768490007157 ATP binding site [chemical binding]; other site 768490007158 Q-loop/lid; other site 768490007159 ABC transporter signature motif; other site 768490007160 Walker B; other site 768490007161 D-loop; other site 768490007162 H-loop/switch region; other site 768490007163 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 768490007164 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768490007165 substrate binding site [chemical binding]; other site 768490007166 ATP binding site [chemical binding]; other site 768490007167 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 768490007168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490007169 dimer interface [polypeptide binding]; other site 768490007170 conserved gate region; other site 768490007171 putative PBP binding loops; other site 768490007172 ABC-ATPase subunit interface; other site 768490007173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490007174 dimer interface [polypeptide binding]; other site 768490007175 conserved gate region; other site 768490007176 putative PBP binding loops; other site 768490007177 ABC-ATPase subunit interface; other site 768490007178 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 768490007179 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 768490007180 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 768490007181 non-specific DNA interactions [nucleotide binding]; other site 768490007182 DNA binding site [nucleotide binding] 768490007183 sequence specific DNA binding site [nucleotide binding]; other site 768490007184 putative cAMP binding site [chemical binding]; other site 768490007185 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 768490007186 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768490007187 nucleotide binding site [chemical binding]; other site 768490007188 Chitin binding domain; Region: Chitin_bind_3; pfam03067 768490007189 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 768490007190 Interdomain contacts; other site 768490007191 Cytokine receptor motif; other site 768490007192 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 768490007193 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 768490007194 Interdomain contacts; other site 768490007195 Cytokine receptor motif; other site 768490007196 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 768490007197 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 768490007198 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 768490007199 putative active site [active] 768490007200 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 768490007201 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 768490007202 Interdomain contacts; other site 768490007203 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 768490007204 guanine deaminase; Provisional; Region: PRK09228 768490007205 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 768490007206 active site 768490007207 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 768490007208 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768490007209 catalytic loop [active] 768490007210 iron binding site [ion binding]; other site 768490007211 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 768490007212 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 768490007213 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 768490007214 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 768490007215 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768490007216 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 768490007217 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 768490007218 XdhC Rossmann domain; Region: XdhC_C; pfam13478 768490007219 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 768490007220 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 768490007221 NAD binding site [chemical binding]; other site 768490007222 sugar binding site [chemical binding]; other site 768490007223 divalent metal binding site [ion binding]; other site 768490007224 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 768490007225 dimer interface [polypeptide binding]; other site 768490007226 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768490007227 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 768490007228 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768490007229 active site turn [active] 768490007230 phosphorylation site [posttranslational modification] 768490007231 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 768490007232 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768490007233 DNA-binding site [nucleotide binding]; DNA binding site 768490007234 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 768490007235 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 768490007236 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 768490007237 Ca binding site [ion binding]; other site 768490007238 active site 768490007239 catalytic site [active] 768490007240 Cytochrome c; Region: Cytochrom_C; pfam00034 768490007241 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 768490007242 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 768490007243 active site 768490007244 Zn binding site [ion binding]; other site 768490007245 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 768490007246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490007247 putative substrate translocation pore; other site 768490007248 Isochorismatase family; Region: Isochorismatase; pfam00857 768490007249 N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015 768490007250 catalytic triad [active] 768490007251 substrate binding site [chemical binding]; other site 768490007252 domain interfaces; other site 768490007253 conserved cis-peptide bond; other site 768490007254 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 768490007255 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768490007256 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 768490007257 catalytic site [active] 768490007258 hypothetical protein; Provisional; Region: PRK06847 768490007259 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 768490007260 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 768490007261 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768490007262 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 768490007263 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 768490007264 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 768490007265 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 768490007266 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768490007267 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 768490007268 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 768490007269 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768490007270 Cytochrome c; Region: Cytochrom_C; pfam00034 768490007271 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768490007272 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768490007273 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 768490007274 HlyD family secretion protein; Region: HlyD; pfam00529 768490007275 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768490007276 HlyD family secretion protein; Region: HlyD_3; pfam13437 768490007277 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 768490007278 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 768490007279 putative active site [active] 768490007280 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768490007281 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768490007282 Walker A/P-loop; other site 768490007283 ATP binding site [chemical binding]; other site 768490007284 Q-loop/lid; other site 768490007285 ABC transporter signature motif; other site 768490007286 Walker B; other site 768490007287 D-loop; other site 768490007288 H-loop/switch region; other site 768490007289 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 768490007290 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 768490007291 homodimer interface [polypeptide binding]; other site 768490007292 homotetramer interface [polypeptide binding]; other site 768490007293 active site pocket [active] 768490007294 cleavage site 768490007295 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 768490007296 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 768490007297 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768490007298 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 768490007299 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768490007300 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768490007301 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 768490007302 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768490007303 catalytic loop [active] 768490007304 iron binding site [ion binding]; other site 768490007305 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 768490007306 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768490007307 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768490007308 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 768490007309 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 768490007310 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768490007311 active site turn [active] 768490007312 phosphorylation site [posttranslational modification] 768490007313 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768490007314 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 768490007315 HPr interaction site; other site 768490007316 glycerol kinase (GK) interaction site [polypeptide binding]; other site 768490007317 active site 768490007318 phosphorylation site [posttranslational modification] 768490007319 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 768490007320 beta-galactosidase; Region: BGL; TIGR03356 768490007321 transcriptional antiterminator BglG; Provisional; Region: PRK09772 768490007322 CAT RNA binding domain; Region: CAT_RBD; smart01061 768490007323 PRD domain; Region: PRD; pfam00874 768490007324 PRD domain; Region: PRD; pfam00874 768490007325 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 768490007326 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490007327 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 768490007328 putative dimerization interface [polypeptide binding]; other site 768490007329 putative substrate binding pocket [chemical binding]; other site 768490007330 Chromate transporter; Region: Chromate_transp; pfam02417 768490007331 Chromate transporter; Region: Chromate_transp; pfam02417 768490007332 Protease inhibitor Inh; Region: Inh; pfam02974 768490007333 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 768490007334 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 768490007335 classical (c) SDRs; Region: SDR_c; cd05233 768490007336 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 768490007337 NAD(P) binding site [chemical binding]; other site 768490007338 active site 768490007339 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768490007340 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768490007341 DNA binding site [nucleotide binding] 768490007342 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 768490007343 putative ligand binding site [chemical binding]; other site 768490007344 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 768490007345 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 768490007346 putative active site [active] 768490007347 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768490007348 EamA-like transporter family; Region: EamA; pfam00892 768490007349 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768490007350 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490007351 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 768490007352 active site 768490007353 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 768490007354 NIPSNAP; Region: NIPSNAP; pfam07978 768490007355 drug efflux system protein MdtG; Provisional; Region: PRK09874 768490007356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490007357 putative substrate translocation pore; other site 768490007358 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 768490007359 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 768490007360 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768490007361 active site 768490007362 motif I; other site 768490007363 motif II; other site 768490007364 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 768490007365 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 768490007366 Coenzyme A binding pocket [chemical binding]; other site 768490007367 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 768490007368 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768490007369 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 768490007370 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 768490007371 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 768490007372 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 768490007373 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 768490007374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490007375 dimer interface [polypeptide binding]; other site 768490007376 conserved gate region; other site 768490007377 putative PBP binding loops; other site 768490007378 ABC-ATPase subunit interface; other site 768490007379 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 768490007380 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 768490007381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490007382 dimer interface [polypeptide binding]; other site 768490007383 conserved gate region; other site 768490007384 putative PBP binding loops; other site 768490007385 ABC-ATPase subunit interface; other site 768490007386 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 768490007387 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768490007388 Walker A/P-loop; other site 768490007389 ATP binding site [chemical binding]; other site 768490007390 Q-loop/lid; other site 768490007391 ABC transporter signature motif; other site 768490007392 Walker B; other site 768490007393 D-loop; other site 768490007394 H-loop/switch region; other site 768490007395 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768490007396 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 768490007397 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768490007398 Walker A/P-loop; other site 768490007399 ATP binding site [chemical binding]; other site 768490007400 Q-loop/lid; other site 768490007401 ABC transporter signature motif; other site 768490007402 Walker B; other site 768490007403 D-loop; other site 768490007404 H-loop/switch region; other site 768490007405 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 768490007406 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 768490007407 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 768490007408 active site 768490007409 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 768490007410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490007411 putative substrate translocation pore; other site 768490007412 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490007413 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490007414 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768490007415 dimerization interface [polypeptide binding]; other site 768490007416 penicillin-binding protein 2; Provisional; Region: PRK10795 768490007417 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 768490007418 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 768490007419 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 768490007420 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 768490007421 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 768490007422 lipoprotein; Provisional; Region: PRK10540 768490007423 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768490007424 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490007425 Coenzyme A binding pocket [chemical binding]; other site 768490007426 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 768490007427 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 768490007428 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 768490007429 Walker A/P-loop; other site 768490007430 ATP binding site [chemical binding]; other site 768490007431 Q-loop/lid; other site 768490007432 ABC transporter signature motif; other site 768490007433 Walker B; other site 768490007434 D-loop; other site 768490007435 H-loop/switch region; other site 768490007436 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768490007437 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490007438 dimer interface [polypeptide binding]; other site 768490007439 conserved gate region; other site 768490007440 putative PBP binding loops; other site 768490007441 ABC-ATPase subunit interface; other site 768490007442 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768490007443 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768490007444 substrate binding pocket [chemical binding]; other site 768490007445 membrane-bound complex binding site; other site 768490007446 hinge residues; other site 768490007447 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 768490007448 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 768490007449 active site 768490007450 non-prolyl cis peptide bond; other site 768490007451 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 768490007452 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490007453 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490007454 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 768490007455 putative effector binding pocket; other site 768490007456 putative dimerization interface [polypeptide binding]; other site 768490007457 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 768490007458 Beta-lactamase; Region: Beta-lactamase; pfam00144 768490007459 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768490007460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490007461 putative substrate translocation pore; other site 768490007462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490007463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490007464 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 768490007465 RibD C-terminal domain; Region: RibD_C; cl17279 768490007466 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 768490007467 Uncharacterized conserved protein [Function unknown]; Region: COG5276 768490007468 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 768490007469 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 768490007470 putative ligand binding site [chemical binding]; other site 768490007471 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 768490007472 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 768490007473 putative active site [active] 768490007474 metal binding site [ion binding]; metal-binding site 768490007475 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 768490007476 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 768490007477 putative NADP binding site [chemical binding]; other site 768490007478 putative substrate binding site [chemical binding]; other site 768490007479 active site 768490007480 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768490007481 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768490007482 Pirin; Region: Pirin; pfam02678 768490007483 Pirin-related protein [General function prediction only]; Region: COG1741 768490007484 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 768490007485 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768490007486 Predicted transcriptional regulators [Transcription]; Region: COG1733 768490007487 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 768490007488 NmrA-like family; Region: NmrA; pfam05368 768490007489 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 768490007490 NADP binding site [chemical binding]; other site 768490007491 active site 768490007492 regulatory binding site [polypeptide binding]; other site 768490007493 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 768490007494 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 768490007495 putative NAD(P) binding site [chemical binding]; other site 768490007496 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490007497 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490007498 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768490007499 putative effector binding pocket; other site 768490007500 dimerization interface [polypeptide binding]; other site 768490007501 Protein of unknown function (DUF419); Region: DUF419; cl15265 768490007502 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 768490007503 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 768490007504 Walker A/P-loop; other site 768490007505 ATP binding site [chemical binding]; other site 768490007506 Q-loop/lid; other site 768490007507 ABC transporter signature motif; other site 768490007508 Walker B; other site 768490007509 D-loop; other site 768490007510 H-loop/switch region; other site 768490007511 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 768490007512 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 768490007513 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490007514 dimer interface [polypeptide binding]; other site 768490007515 conserved gate region; other site 768490007516 ABC-ATPase subunit interface; other site 768490007517 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 768490007518 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490007519 dimer interface [polypeptide binding]; other site 768490007520 conserved gate region; other site 768490007521 putative PBP binding loops; other site 768490007522 ABC-ATPase subunit interface; other site 768490007523 Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867 768490007524 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 768490007525 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 768490007526 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 768490007527 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 768490007528 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768490007529 active site turn [active] 768490007530 phosphorylation site [posttranslational modification] 768490007531 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 768490007532 trimer interface; other site 768490007533 sugar binding site [chemical binding]; other site 768490007534 lac repressor; Reviewed; Region: lacI; PRK09526 768490007535 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768490007536 DNA binding site [nucleotide binding] 768490007537 domain linker motif; other site 768490007538 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 768490007539 ligand binding site [chemical binding]; other site 768490007540 dimerization interface (open form) [polypeptide binding]; other site 768490007541 dimerization interface (closed form) [polypeptide binding]; other site 768490007542 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768490007543 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768490007544 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768490007545 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490007546 putative substrate translocation pore; other site 768490007547 Alcaligenes xylosoxidans NreA and related domains; this domain family was previously known as part of DUF156; Region: NreA-like_DUF156; cd10154 768490007548 putative homodimer interface [polypeptide binding]; other site 768490007549 putative homotetramer interface [polypeptide binding]; other site 768490007550 putative metal binding site [ion binding]; other site 768490007551 putative homodimer-homodimer interface [polypeptide binding]; other site 768490007552 putative allosteric switch controlling residues; other site 768490007553 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 768490007554 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 768490007555 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 768490007556 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490007557 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 768490007558 hypothetical protein; Provisional; Region: PRK05208 768490007559 Rdx family; Region: Rdx; cl01407 768490007560 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 768490007561 Bacterial transcriptional regulator; Region: IclR; pfam01614 768490007562 PAS domain; Region: PAS; smart00091 768490007563 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768490007564 Walker A motif; other site 768490007565 ATP binding site [chemical binding]; other site 768490007566 Walker B motif; other site 768490007567 arginine finger; other site 768490007568 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768490007569 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768490007570 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768490007571 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 768490007572 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 768490007573 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 768490007574 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 768490007575 putative ligand binding site [chemical binding]; other site 768490007576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490007577 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768490007578 transcriptional regulator, ArgP family; Region: argP; TIGR03298 768490007579 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490007580 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768490007581 putative effector binding pocket; other site 768490007582 dimerization interface [polypeptide binding]; other site 768490007583 Amidinotransferase; Region: Amidinotransf; cl12043 768490007584 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 768490007585 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768490007586 substrate binding pocket [chemical binding]; other site 768490007587 membrane-bound complex binding site; other site 768490007588 hinge residues; other site 768490007589 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768490007590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490007591 dimer interface [polypeptide binding]; other site 768490007592 conserved gate region; other site 768490007593 putative PBP binding loops; other site 768490007594 ABC-ATPase subunit interface; other site 768490007595 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768490007596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490007597 dimer interface [polypeptide binding]; other site 768490007598 conserved gate region; other site 768490007599 putative PBP binding loops; other site 768490007600 ABC-ATPase subunit interface; other site 768490007601 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768490007602 dimerization interface [polypeptide binding]; other site 768490007603 putative DNA binding site [nucleotide binding]; other site 768490007604 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 768490007605 putative Zn2+ binding site [ion binding]; other site 768490007606 AsnC family; Region: AsnC_trans_reg; pfam01037 768490007607 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 768490007608 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 768490007609 active site 768490007610 Zn binding site [ion binding]; other site 768490007611 Fic/DOC family; Region: Fic; pfam02661 768490007612 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 768490007613 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768490007614 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768490007615 Walker A/P-loop; other site 768490007616 ATP binding site [chemical binding]; other site 768490007617 Q-loop/lid; other site 768490007618 ABC transporter signature motif; other site 768490007619 Walker B; other site 768490007620 D-loop; other site 768490007621 H-loop/switch region; other site 768490007622 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 768490007623 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 768490007624 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 768490007625 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 768490007626 NAD binding site [chemical binding]; other site 768490007627 substrate binding site [chemical binding]; other site 768490007628 catalytic Zn binding site [ion binding]; other site 768490007629 tetramer interface [polypeptide binding]; other site 768490007630 structural Zn binding site [ion binding]; other site 768490007631 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Region: ALDH_ACDHII_AcoD-like; cd07559 768490007632 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 768490007633 NAD(P) binding site [chemical binding]; other site 768490007634 catalytic residues [active] 768490007635 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 768490007636 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768490007637 Walker A motif; other site 768490007638 ATP binding site [chemical binding]; other site 768490007639 Walker B motif; other site 768490007640 arginine finger; other site 768490007641 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768490007642 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768490007643 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768490007644 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 768490007645 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 768490007646 NAD(P) binding site [chemical binding]; other site 768490007647 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768490007648 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768490007649 substrate binding pocket [chemical binding]; other site 768490007650 membrane-bound complex binding site; other site 768490007651 hinge residues; other site 768490007652 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490007653 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490007654 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768490007655 putative effector binding pocket; other site 768490007656 dimerization interface [polypeptide binding]; other site 768490007657 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490007658 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768490007659 putative substrate translocation pore; other site 768490007660 PAS fold; Region: PAS_4; pfam08448 768490007661 PAS fold; Region: PAS_4; pfam08448 768490007662 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 768490007663 putative active site [active] 768490007664 heme pocket [chemical binding]; other site 768490007665 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768490007666 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768490007667 metal binding site [ion binding]; metal-binding site 768490007668 active site 768490007669 I-site; other site 768490007670 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768490007671 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 768490007672 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 768490007673 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 768490007674 Trp docking motif [polypeptide binding]; other site 768490007675 putative active site [active] 768490007676 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 768490007677 TAP-like protein; Region: Abhydrolase_4; pfam08386 768490007678 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490007679 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 768490007680 putative substrate binding pocket [chemical binding]; other site 768490007681 putative dimerization interface [polypeptide binding]; other site 768490007682 C factor cell-cell signaling protein; Provisional; Region: PRK09009 768490007683 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 768490007684 NADP binding site [chemical binding]; other site 768490007685 homodimer interface [polypeptide binding]; other site 768490007686 active site 768490007687 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 768490007688 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490007689 catalytic residue [active] 768490007690 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 768490007691 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768490007692 inhibitor-cofactor binding pocket; inhibition site 768490007693 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490007694 catalytic residue [active] 768490007695 Fucose-binding lectin II (PA-IIL); Region: PA-IIL; pfam07472 768490007696 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 768490007697 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 768490007698 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 768490007699 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 768490007700 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 768490007701 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768490007702 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768490007703 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768490007704 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768490007705 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768490007706 Surface antigen; Region: Bac_surface_Ag; pfam01103 768490007707 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 768490007708 active site 768490007709 catalytic residues [active] 768490007710 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768490007711 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768490007712 DNA binding site [nucleotide binding] 768490007713 domain linker motif; other site 768490007714 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 768490007715 ligand binding site [chemical binding]; other site 768490007716 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 768490007717 active site 768490007718 P-loop; other site 768490007719 phosphorylation site [posttranslational modification] 768490007720 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 768490007721 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 768490007722 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 768490007723 beta-galactosidase; Region: BGL; TIGR03356 768490007724 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 768490007725 methionine cluster; other site 768490007726 active site 768490007727 phosphorylation site [posttranslational modification] 768490007728 metal binding site [ion binding]; metal-binding site 768490007729 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 768490007730 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768490007731 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768490007732 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 768490007733 ABC transporter transmembrane region; Region: ABC_membrane_3; pfam13748 768490007734 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 768490007735 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768490007736 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 768490007737 E3 interaction surface; other site 768490007738 lipoyl attachment site [posttranslational modification]; other site 768490007739 e3 binding domain; Region: E3_binding; pfam02817 768490007740 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 768490007741 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 768490007742 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 768490007743 dimer interface [polypeptide binding]; other site 768490007744 TPP-binding site [chemical binding]; other site 768490007745 MarR family; Region: MarR; pfam01047 768490007746 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768490007747 FAD dependent oxidoreductase; Region: DAO; pfam01266 768490007748 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 768490007749 Predicted transcriptional regulators [Transcription]; Region: COG1733 768490007750 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 768490007751 short chain dehydrogenase; Provisional; Region: PRK06179 768490007752 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 768490007753 NADP binding site [chemical binding]; other site 768490007754 active site 768490007755 steroid binding site; other site 768490007756 YCII-related domain; Region: YCII; cl00999 768490007757 Predicted transcriptional regulators [Transcription]; Region: COG1733 768490007758 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 768490007759 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 768490007760 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 768490007761 NADP binding site [chemical binding]; other site 768490007762 MarR family; Region: MarR_2; cl17246 768490007763 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768490007764 EamA-like transporter family; Region: EamA; pfam00892 768490007765 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 768490007766 EamA-like transporter family; Region: EamA; pfam00892 768490007767 Nitroreductase [Energy production and conversion]; Region: NfnB; COG0778 768490007768 FMN binding site [chemical binding]; other site 768490007769 Winged helix-turn helix; Region: HTH_29; pfam13551 768490007770 Helix-turn-helix domain; Region: HTH_28; pfam13518 768490007771 Homeodomain-like domain; Region: HTH_32; pfam13565 768490007772 Integrase core domain; Region: rve; pfam00665 768490007773 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768490007774 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 768490007775 catalytic site [active] 768490007776 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 768490007777 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490007778 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 768490007779 dimerization interface [polypeptide binding]; other site 768490007780 substrate binding pocket [chemical binding]; other site 768490007781 SnoaL-like domain; Region: SnoaL_4; pfam13577 768490007782 Amidohydrolase; Region: Amidohydro_2; pfam04909 768490007783 Methyltransferase domain; Region: Methyltransf_23; pfam13489 768490007784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 768490007785 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490007786 S-adenosylmethionine binding site [chemical binding]; other site 768490007787 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 768490007788 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 768490007789 putative ligand binding site [chemical binding]; other site 768490007790 NAD binding site [chemical binding]; other site 768490007791 catalytic site [active] 768490007792 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490007793 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490007794 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 768490007795 putative substrate binding pocket [chemical binding]; other site 768490007796 putative dimerization interface [polypeptide binding]; other site 768490007797 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 768490007798 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 768490007799 Predicted transcriptional regulators [Transcription]; Region: COG1733 768490007800 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 768490007801 Transcriptional regulators [Transcription]; Region: MarR; COG1846 768490007802 MarR family; Region: MarR_2; pfam12802 768490007803 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490007804 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768490007805 Coenzyme A binding pocket [chemical binding]; other site 768490007806 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 768490007807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490007808 putative substrate translocation pore; other site 768490007809 Uncharacterized conserved protein [Function unknown]; Region: COG4925 768490007810 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 768490007811 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 768490007812 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490007813 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490007814 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 768490007815 putative effector binding pocket; other site 768490007816 putative dimerization interface [polypeptide binding]; other site 768490007817 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490007818 transcriptional activator TtdR; Provisional; Region: PRK09801 768490007819 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768490007820 dimerization interface [polypeptide binding]; other site 768490007821 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 768490007822 active site 768490007823 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 768490007824 YheO-like PAS domain; Region: PAS_6; pfam08348 768490007825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 768490007826 HTH domain; Region: HTH_22; pfam13309 768490007827 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 768490007828 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 768490007829 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 768490007830 NAD(P) binding site [chemical binding]; other site 768490007831 intracellular protease, PfpI family; Region: PfpI; TIGR01382 768490007832 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 768490007833 conserved cys residue [active] 768490007834 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 768490007835 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 768490007836 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 768490007837 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 768490007838 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768490007839 HlyD family secretion protein; Region: HlyD_3; pfam13437 768490007840 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 768490007841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490007842 putative substrate translocation pore; other site 768490007843 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490007844 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768490007845 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768490007846 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 768490007847 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 768490007848 active site 768490007849 homotetramer interface [polypeptide binding]; other site 768490007850 homodimer interface [polypeptide binding]; other site 768490007851 benzoate transporter; Region: benE; TIGR00843 768490007852 Benzoate membrane transport protein; Region: BenE; pfam03594 768490007853 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768490007854 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768490007855 DNA-binding site [nucleotide binding]; DNA binding site 768490007856 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768490007857 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490007858 homodimer interface [polypeptide binding]; other site 768490007859 catalytic residue [active] 768490007860 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768490007861 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768490007862 non-specific DNA binding site [nucleotide binding]; other site 768490007863 salt bridge; other site 768490007864 sequence-specific DNA binding site [nucleotide binding]; other site 768490007865 Cupin domain; Region: Cupin_2; cl17218 768490007866 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768490007867 EamA-like transporter family; Region: EamA; pfam00892 768490007868 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490007869 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490007870 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768490007871 dimerization interface [polypeptide binding]; other site 768490007872 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 768490007873 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 768490007874 active site 768490007875 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 768490007876 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 768490007877 Flavin binding site [chemical binding]; other site 768490007878 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 768490007879 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 768490007880 active site 768490007881 non-prolyl cis peptide bond; other site 768490007882 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 768490007883 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 768490007884 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 768490007885 Walker A/P-loop; other site 768490007886 ATP binding site [chemical binding]; other site 768490007887 Q-loop/lid; other site 768490007888 ABC transporter signature motif; other site 768490007889 Walker B; other site 768490007890 D-loop; other site 768490007891 H-loop/switch region; other site 768490007892 NIL domain; Region: NIL; cl09633 768490007893 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490007894 dimer interface [polypeptide binding]; other site 768490007895 conserved gate region; other site 768490007896 ABC-ATPase subunit interface; other site 768490007897 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 768490007898 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768490007899 substrate binding pocket [chemical binding]; other site 768490007900 membrane-bound complex binding site; other site 768490007901 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 768490007902 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 768490007903 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768490007904 catalytic residue [active] 768490007905 serine O-acetyltransferase; Region: cysE; TIGR01172 768490007906 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 768490007907 trimer interface [polypeptide binding]; other site 768490007908 active site 768490007909 substrate binding site [chemical binding]; other site 768490007910 CoA binding site [chemical binding]; other site 768490007911 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 768490007912 active site residue [active] 768490007913 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 768490007914 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 768490007915 putative ligand binding site [chemical binding]; other site 768490007916 NAD binding site [chemical binding]; other site 768490007917 catalytic site [active] 768490007918 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490007919 D-galactonate transporter; Region: 2A0114; TIGR00893 768490007920 putative substrate translocation pore; other site 768490007921 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490007922 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 768490007923 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768490007924 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768490007925 putative active site [active] 768490007926 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 768490007927 beta-galactosidase; Region: BGL; TIGR03356 768490007928 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 768490007929 heterodimer interface [polypeptide binding]; other site 768490007930 multimer interface [polypeptide binding]; other site 768490007931 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 768490007932 active site 768490007933 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 768490007934 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 768490007935 heterodimer interface [polypeptide binding]; other site 768490007936 active site 768490007937 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 768490007938 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490007939 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768490007940 dimerization interface [polypeptide binding]; other site 768490007941 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 768490007942 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 768490007943 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 768490007944 tetramer interface [polypeptide binding]; other site 768490007945 active site 768490007946 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 768490007947 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768490007948 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 768490007949 benzoate transport; Region: 2A0115; TIGR00895 768490007950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490007951 putative substrate translocation pore; other site 768490007952 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490007953 benzoate transport; Region: 2A0115; TIGR00895 768490007954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490007955 putative substrate translocation pore; other site 768490007956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490007957 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 768490007958 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 768490007959 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 768490007960 shikimate binding site; other site 768490007961 NAD(P) binding site [chemical binding]; other site 768490007962 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 768490007963 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 768490007964 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 768490007965 dimer interface [polypeptide binding]; other site 768490007966 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 768490007967 active site 768490007968 Fe binding site [ion binding]; other site 768490007969 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 768490007970 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 768490007971 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768490007972 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 768490007973 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768490007974 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 768490007975 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 768490007976 Bacterial transcriptional regulator; Region: IclR; pfam01614 768490007977 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 768490007978 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 768490007979 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768490007980 catalytic residue [active] 768490007981 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 768490007982 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 768490007983 dimer interface [polypeptide binding]; other site 768490007984 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 768490007985 MASE1; Region: MASE1; cl17823 768490007986 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768490007987 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768490007988 metal binding site [ion binding]; metal-binding site 768490007989 active site 768490007990 I-site; other site 768490007991 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768490007992 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490007993 Coenzyme A binding pocket [chemical binding]; other site 768490007994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490007995 dimer interface [polypeptide binding]; other site 768490007996 conserved gate region; other site 768490007997 ABC-ATPase subunit interface; other site 768490007998 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 768490007999 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 768490008000 Walker A/P-loop; other site 768490008001 ATP binding site [chemical binding]; other site 768490008002 Q-loop/lid; other site 768490008003 ABC transporter signature motif; other site 768490008004 Walker B; other site 768490008005 D-loop; other site 768490008006 H-loop/switch region; other site 768490008007 NIL domain; Region: NIL; pfam09383 768490008008 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 768490008009 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 768490008010 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 768490008011 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 768490008012 putative N- and C-terminal domain interface [polypeptide binding]; other site 768490008013 putative active site [active] 768490008014 MgATP binding site [chemical binding]; other site 768490008015 catalytic site [active] 768490008016 metal binding site [ion binding]; metal-binding site 768490008017 putative xylulose binding site [chemical binding]; other site 768490008018 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 768490008019 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 768490008020 putative ligand binding site [chemical binding]; other site 768490008021 putative NAD binding site [chemical binding]; other site 768490008022 catalytic site [active] 768490008023 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 768490008024 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768490008025 substrate binding site [chemical binding]; other site 768490008026 ATP binding site [chemical binding]; other site 768490008027 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768490008028 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768490008029 TM-ABC transporter signature motif; other site 768490008030 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768490008031 TM-ABC transporter signature motif; other site 768490008032 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 768490008033 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768490008034 Walker A/P-loop; other site 768490008035 ATP binding site [chemical binding]; other site 768490008036 Q-loop/lid; other site 768490008037 ABC transporter signature motif; other site 768490008038 Walker B; other site 768490008039 D-loop; other site 768490008040 H-loop/switch region; other site 768490008041 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768490008042 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 768490008043 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 768490008044 putative ligand binding site [chemical binding]; other site 768490008045 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 768490008046 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 768490008047 Ca binding site [ion binding]; other site 768490008048 active site 768490008049 catalytic site [active] 768490008050 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 768490008051 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 768490008052 Walker A/P-loop; other site 768490008053 ATP binding site [chemical binding]; other site 768490008054 Q-loop/lid; other site 768490008055 ABC transporter signature motif; other site 768490008056 Walker B; other site 768490008057 D-loop; other site 768490008058 H-loop/switch region; other site 768490008059 TOBE domain; Region: TOBE_2; pfam08402 768490008060 alpha-galactosidase; Provisional; Region: PRK15076 768490008061 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 768490008062 NAD(P) binding site [chemical binding]; other site 768490008063 LDH/MDH dimer interface [polypeptide binding]; other site 768490008064 substrate binding site [chemical binding]; other site 768490008065 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 768490008066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490008067 dimer interface [polypeptide binding]; other site 768490008068 conserved gate region; other site 768490008069 putative PBP binding loops; other site 768490008070 ABC-ATPase subunit interface; other site 768490008071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490008072 dimer interface [polypeptide binding]; other site 768490008073 conserved gate region; other site 768490008074 putative PBP binding loops; other site 768490008075 ABC-ATPase subunit interface; other site 768490008076 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 768490008077 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 768490008078 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490008079 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490008080 LysR substrate binding domain; Region: LysR_substrate; pfam03466 768490008081 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768490008082 active site turn [active] 768490008083 phosphorylation site [posttranslational modification] 768490008084 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 768490008085 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 768490008086 Mechanosensitive ion channel; Region: MS_channel; pfam00924 768490008087 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 768490008088 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768490008089 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768490008090 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 768490008091 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768490008092 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768490008093 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490008094 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 768490008095 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 768490008096 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 768490008097 active site 768490008098 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 768490008099 Cation efflux family; Region: Cation_efflux; cl00316 768490008100 Cation efflux family; Region: Cation_efflux; cl00316 768490008101 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 768490008102 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 768490008103 Divalent cation transporter; Region: MgtE; pfam01769 768490008104 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 768490008105 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 768490008106 peptide binding site [polypeptide binding]; other site 768490008107 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768490008108 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 768490008109 active site 768490008110 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768490008111 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490008112 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768490008113 dimerization interface [polypeptide binding]; other site 768490008114 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 768490008115 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 768490008116 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 768490008117 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490008118 dimer interface [polypeptide binding]; other site 768490008119 conserved gate region; other site 768490008120 putative PBP binding loops; other site 768490008121 ABC-ATPase subunit interface; other site 768490008122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490008123 dimer interface [polypeptide binding]; other site 768490008124 conserved gate region; other site 768490008125 putative PBP binding loops; other site 768490008126 ABC-ATPase subunit interface; other site 768490008127 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 768490008128 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 768490008129 Walker A/P-loop; other site 768490008130 ATP binding site [chemical binding]; other site 768490008131 Q-loop/lid; other site 768490008132 ABC transporter signature motif; other site 768490008133 Walker B; other site 768490008134 D-loop; other site 768490008135 H-loop/switch region; other site 768490008136 elongation factor G; Reviewed; Region: PRK00007 768490008137 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 768490008138 G1 box; other site 768490008139 putative GEF interaction site [polypeptide binding]; other site 768490008140 GTP/Mg2+ binding site [chemical binding]; other site 768490008141 Switch I region; other site 768490008142 G2 box; other site 768490008143 G3 box; other site 768490008144 Switch II region; other site 768490008145 G4 box; other site 768490008146 G5 box; other site 768490008147 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 768490008148 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 768490008149 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 768490008150 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768490008151 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 768490008152 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 768490008153 GIY-YIG motif/motif A; other site 768490008154 MarR family; Region: MarR_2; cl17246 768490008155 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768490008156 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490008157 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768490008158 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 768490008159 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 768490008160 tetramerization interface [polypeptide binding]; other site 768490008161 NAD(P) binding site [chemical binding]; other site 768490008162 catalytic residues [active] 768490008163 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 768490008164 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 768490008165 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 768490008166 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 768490008167 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768490008168 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768490008169 Cupin domain; Region: Cupin_2; pfam07883 768490008170 K+ potassium transporter; Region: K_trans; pfam02705 768490008171 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768490008172 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490008173 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 768490008174 dimerization interface [polypeptide binding]; other site 768490008175 substrate binding pocket [chemical binding]; other site 768490008176 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768490008177 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 768490008178 TM-ABC transporter signature motif; other site 768490008179 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 768490008180 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768490008181 TM-ABC transporter signature motif; other site 768490008182 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 768490008183 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 768490008184 Walker A/P-loop; other site 768490008185 ATP binding site [chemical binding]; other site 768490008186 Q-loop/lid; other site 768490008187 ABC transporter signature motif; other site 768490008188 Walker B; other site 768490008189 D-loop; other site 768490008190 H-loop/switch region; other site 768490008191 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 768490008192 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 768490008193 Walker A/P-loop; other site 768490008194 ATP binding site [chemical binding]; other site 768490008195 Q-loop/lid; other site 768490008196 ABC transporter signature motif; other site 768490008197 Walker B; other site 768490008198 D-loop; other site 768490008199 H-loop/switch region; other site 768490008200 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 768490008201 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 768490008202 dimerization interface [polypeptide binding]; other site 768490008203 ligand binding site [chemical binding]; other site 768490008204 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 768490008205 allantoate amidohydrolase; Reviewed; Region: PRK09290 768490008206 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 768490008207 active site 768490008208 metal binding site [ion binding]; metal-binding site 768490008209 dimer interface [polypeptide binding]; other site 768490008210 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768490008211 dimerization interface [polypeptide binding]; other site 768490008212 putative DNA binding site [nucleotide binding]; other site 768490008213 putative Zn2+ binding site [ion binding]; other site 768490008214 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 768490008215 putative hydrophobic ligand binding site [chemical binding]; other site 768490008216 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 768490008217 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 768490008218 Cl binding site [ion binding]; other site 768490008219 oligomer interface [polypeptide binding]; other site 768490008220 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 768490008221 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 768490008222 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 768490008223 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 768490008224 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 768490008225 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 768490008226 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 768490008227 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 768490008228 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768490008229 DNA-binding site [nucleotide binding]; DNA binding site 768490008230 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768490008231 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768490008232 catalytic residue [active] 768490008233 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 768490008234 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 768490008235 catalytic triad [active] 768490008236 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 768490008237 dimer interface [polypeptide binding]; other site 768490008238 pyridoxamine kinase; Validated; Region: PRK05756 768490008239 pyridoxal binding site [chemical binding]; other site 768490008240 ATP binding site [chemical binding]; other site 768490008241 Flagellar regulator YcgR; Region: YcgR; pfam07317 768490008242 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 768490008243 PilZ domain; Region: PilZ; pfam07238 768490008244 N-formylglutamate amidohydrolase; Region: FGase; cl01522 768490008245 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 768490008246 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 768490008247 putative acyl-acceptor binding pocket; other site 768490008248 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 768490008249 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 768490008250 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 768490008251 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 768490008252 DNA binding site [nucleotide binding] 768490008253 active site 768490008254 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 768490008255 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 768490008256 ligand binding site [chemical binding]; other site 768490008257 flexible hinge region; other site 768490008258 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 768490008259 putative switch regulator; other site 768490008260 non-specific DNA interactions [nucleotide binding]; other site 768490008261 DNA binding site [nucleotide binding] 768490008262 sequence specific DNA binding site [nucleotide binding]; other site 768490008263 putative cAMP binding site [chemical binding]; other site 768490008264 universal stress protein UspE; Provisional; Region: PRK11175 768490008265 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 768490008266 Ligand Binding Site [chemical binding]; other site 768490008267 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 768490008268 Ligand Binding Site [chemical binding]; other site 768490008269 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 768490008270 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 768490008271 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 768490008272 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 768490008273 ligand binding site [chemical binding]; other site 768490008274 homodimer interface [polypeptide binding]; other site 768490008275 NAD(P) binding site [chemical binding]; other site 768490008276 trimer interface B [polypeptide binding]; other site 768490008277 trimer interface A [polypeptide binding]; other site 768490008278 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 768490008279 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 768490008280 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 768490008281 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 768490008282 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 768490008283 dihydromonapterin reductase; Provisional; Region: PRK06483 768490008284 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768490008285 NAD(P) binding site [chemical binding]; other site 768490008286 active site 768490008287 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 768490008288 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490008289 active site 768490008290 phosphorylation site [posttranslational modification] 768490008291 intermolecular recognition site; other site 768490008292 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768490008293 DNA binding site [nucleotide binding] 768490008294 sensor protein RstB; Provisional; Region: PRK10604 768490008295 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768490008296 dimerization interface [polypeptide binding]; other site 768490008297 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768490008298 dimer interface [polypeptide binding]; other site 768490008299 phosphorylation site [posttranslational modification] 768490008300 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490008301 ATP binding site [chemical binding]; other site 768490008302 Mg2+ binding site [ion binding]; other site 768490008303 G-X-G motif; other site 768490008304 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 768490008305 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 768490008306 active site 768490008307 Zn binding site [ion binding]; other site 768490008308 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 768490008309 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 768490008310 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 768490008311 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 768490008312 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768490008313 ATP binding site [chemical binding]; other site 768490008314 putative Mg++ binding site [ion binding]; other site 768490008315 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768490008316 nucleotide binding region [chemical binding]; other site 768490008317 ATP-binding site [chemical binding]; other site 768490008318 Helicase associated domain (HA2); Region: HA2; pfam04408 768490008319 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 768490008320 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 768490008321 azoreductase; Reviewed; Region: PRK00170 768490008322 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768490008323 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 768490008324 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 768490008325 hypothetical protein; Provisional; Region: PRK10695 768490008326 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 768490008327 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 768490008328 putative ligand binding site [chemical binding]; other site 768490008329 putative NAD binding site [chemical binding]; other site 768490008330 catalytic site [active] 768490008331 heat-inducible protein; Provisional; Region: PRK10449 768490008332 Domain of unknown function (DUF333); Region: DUF333; pfam03891 768490008333 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 768490008334 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 768490008335 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 768490008336 dimer interface [polypeptide binding]; other site 768490008337 PYR/PP interface [polypeptide binding]; other site 768490008338 TPP binding site [chemical binding]; other site 768490008339 substrate binding site [chemical binding]; other site 768490008340 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 768490008341 Domain of unknown function; Region: EKR; pfam10371 768490008342 4Fe-4S binding domain; Region: Fer4_6; pfam12837 768490008343 4Fe-4S binding domain; Region: Fer4; pfam00037 768490008344 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 768490008345 TPP-binding site [chemical binding]; other site 768490008346 dimer interface [polypeptide binding]; other site 768490008347 Alginate lyase; Region: Alginate_lyase; pfam05426 768490008348 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768490008349 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768490008350 non-specific DNA binding site [nucleotide binding]; other site 768490008351 salt bridge; other site 768490008352 sequence-specific DNA binding site [nucleotide binding]; other site 768490008353 Cupin domain; Region: Cupin_2; cl17218 768490008354 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 768490008355 B3/4 domain; Region: B3_4; pfam03483 768490008356 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 768490008357 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 768490008358 Ligand Binding Site [chemical binding]; other site 768490008359 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 768490008360 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768490008361 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 768490008362 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 768490008363 Cl binding site [ion binding]; other site 768490008364 oligomer interface [polypeptide binding]; other site 768490008365 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 768490008366 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 768490008367 peptide binding site [polypeptide binding]; other site 768490008368 Flagellar regulator YcgR; Region: YcgR; pfam07317 768490008369 murein peptide amidase A; Provisional; Region: PRK10602 768490008370 active site 768490008371 Zn binding site [ion binding]; other site 768490008372 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 768490008373 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 768490008374 active site 768490008375 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 768490008376 dimer interface [polypeptide binding]; other site 768490008377 catalytic triad [active] 768490008378 peroxidatic and resolving cysteines [active] 768490008379 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 768490008380 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 768490008381 putative aromatic amino acid binding site; other site 768490008382 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768490008383 putative active site [active] 768490008384 heme pocket [chemical binding]; other site 768490008385 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768490008386 Walker A motif; other site 768490008387 ATP binding site [chemical binding]; other site 768490008388 Walker B motif; other site 768490008389 arginine finger; other site 768490008390 hypothetical protein; Provisional; Region: PRK05415 768490008391 Domain of unknown function (DUF697); Region: DUF697; cl12064 768490008392 Predicted ATPase [General function prediction only]; Region: COG3106 768490008393 Phage shock protein PspD (Phageshock_PspD); Region: Phageshock_PspD; pfam09584 768490008394 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 768490008395 phage shock protein C; Region: phageshock_pspC; TIGR02978 768490008396 phage shock protein B; Provisional; Region: pspB; PRK09458 768490008397 phage shock protein PspA; Provisional; Region: PRK10698 768490008398 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 768490008399 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768490008400 Walker A motif; other site 768490008401 ATP binding site [chemical binding]; other site 768490008402 Walker B motif; other site 768490008403 arginine finger; other site 768490008404 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768490008405 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 768490008406 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 768490008407 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 768490008408 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 768490008409 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 768490008410 trimer interface [polypeptide binding]; other site 768490008411 active site 768490008412 putative GTP cyclohydrolase; Provisional; Region: PRK13674 768490008413 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 768490008414 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 768490008415 peptide binding site [polypeptide binding]; other site 768490008416 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 768490008417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490008418 dimer interface [polypeptide binding]; other site 768490008419 conserved gate region; other site 768490008420 putative PBP binding loops; other site 768490008421 ABC-ATPase subunit interface; other site 768490008422 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 768490008423 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 768490008424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490008425 dimer interface [polypeptide binding]; other site 768490008426 conserved gate region; other site 768490008427 putative PBP binding loops; other site 768490008428 ABC-ATPase subunit interface; other site 768490008429 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 768490008430 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768490008431 Walker A/P-loop; other site 768490008432 ATP binding site [chemical binding]; other site 768490008433 Q-loop/lid; other site 768490008434 ABC transporter signature motif; other site 768490008435 Walker B; other site 768490008436 D-loop; other site 768490008437 H-loop/switch region; other site 768490008438 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 768490008439 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 768490008440 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768490008441 Walker A/P-loop; other site 768490008442 ATP binding site [chemical binding]; other site 768490008443 Q-loop/lid; other site 768490008444 ABC transporter signature motif; other site 768490008445 Walker B; other site 768490008446 D-loop; other site 768490008447 H-loop/switch region; other site 768490008448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 768490008449 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 768490008450 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 768490008451 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490008452 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490008453 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768490008454 dimerization interface [polypeptide binding]; other site 768490008455 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 768490008456 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 768490008457 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 768490008458 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 768490008459 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 768490008460 putative molybdopterin cofactor binding site [chemical binding]; other site 768490008461 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 768490008462 putative molybdopterin cofactor binding site; other site 768490008463 exoribonuclease II; Provisional; Region: PRK05054 768490008464 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 768490008465 RNB domain; Region: RNB; pfam00773 768490008466 S1 RNA binding domain; Region: S1; pfam00575 768490008467 carbon starvation protein A; Provisional; Region: PRK15015 768490008468 Carbon starvation protein CstA; Region: CstA; pfam02554 768490008469 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 768490008470 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 768490008471 active site 768490008472 intersubunit interactions; other site 768490008473 catalytic residue [active] 768490008474 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 768490008475 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 768490008476 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 768490008477 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 768490008478 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 768490008479 intersubunit interface [polypeptide binding]; other site 768490008480 active site 768490008481 Zn2+ binding site [ion binding]; other site 768490008482 lipoprotein; Provisional; Region: PRK10540 768490008483 translation initiation factor Sui1; Validated; Region: PRK06824 768490008484 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 768490008485 putative rRNA binding site [nucleotide binding]; other site 768490008486 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 768490008487 active site 768490008488 dimer interface [polypeptide binding]; other site 768490008489 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 768490008490 tetratricopeptide repeat protein; Provisional; Region: PRK11788 768490008491 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 768490008492 TPR motif; other site 768490008493 binding surface 768490008494 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 768490008495 binding surface 768490008496 TPR motif; other site 768490008497 Predicted membrane protein [Function unknown]; Region: COG3771 768490008498 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 768490008499 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 768490008500 active site 768490008501 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 768490008502 dimerization interface [polypeptide binding]; other site 768490008503 active site 768490008504 aconitate hydratase; Validated; Region: PRK09277 768490008505 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 768490008506 substrate binding site [chemical binding]; other site 768490008507 ligand binding site [chemical binding]; other site 768490008508 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 768490008509 substrate binding site [chemical binding]; other site 768490008510 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 768490008511 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490008512 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 768490008513 substrate binding site [chemical binding]; other site 768490008514 putative dimerization interface [polypeptide binding]; other site 768490008515 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 768490008516 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 768490008517 active site 768490008518 interdomain interaction site; other site 768490008519 putative metal-binding site [ion binding]; other site 768490008520 nucleotide binding site [chemical binding]; other site 768490008521 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 768490008522 domain I; other site 768490008523 DNA binding groove [nucleotide binding] 768490008524 phosphate binding site [ion binding]; other site 768490008525 domain II; other site 768490008526 domain III; other site 768490008527 nucleotide binding site [chemical binding]; other site 768490008528 catalytic site [active] 768490008529 domain IV; other site 768490008530 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 768490008531 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 768490008532 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 768490008533 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 768490008534 hypothetical protein; Provisional; Region: PRK11037 768490008535 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 768490008536 putative inner membrane peptidase; Provisional; Region: PRK11778 768490008537 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 768490008538 tandem repeat interface [polypeptide binding]; other site 768490008539 oligomer interface [polypeptide binding]; other site 768490008540 active site residues [active] 768490008541 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 768490008542 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 768490008543 NADP binding site [chemical binding]; other site 768490008544 homodimer interface [polypeptide binding]; other site 768490008545 active site 768490008546 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 768490008547 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 768490008548 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 768490008549 homodimer interface [polypeptide binding]; other site 768490008550 Walker A motif; other site 768490008551 ATP binding site [chemical binding]; other site 768490008552 hydroxycobalamin binding site [chemical binding]; other site 768490008553 Walker B motif; other site 768490008554 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 768490008555 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768490008556 RNA binding surface [nucleotide binding]; other site 768490008557 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 768490008558 probable active site [active] 768490008559 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768490008560 hypothetical protein; Provisional; Region: PRK11630 768490008561 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 768490008562 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 768490008563 active site 768490008564 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 768490008565 anthranilate synthase component I; Provisional; Region: PRK13564 768490008566 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 768490008567 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 768490008568 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 768490008569 Glutamine amidotransferase class-I; Region: GATase; pfam00117 768490008570 glutamine binding [chemical binding]; other site 768490008571 catalytic triad [active] 768490008572 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 768490008573 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 768490008574 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 768490008575 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 768490008576 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 768490008577 active site 768490008578 ribulose/triose binding site [chemical binding]; other site 768490008579 phosphate binding site [ion binding]; other site 768490008580 substrate (anthranilate) binding pocket [chemical binding]; other site 768490008581 product (indole) binding pocket [chemical binding]; other site 768490008582 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 768490008583 active site 768490008584 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 768490008585 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 768490008586 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490008587 catalytic residue [active] 768490008588 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 768490008589 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 768490008590 substrate binding site [chemical binding]; other site 768490008591 active site 768490008592 catalytic residues [active] 768490008593 heterodimer interface [polypeptide binding]; other site 768490008594 BON domain; Region: BON; pfam04972 768490008595 outer membrane protein W; Provisional; Region: PRK10959 768490008596 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 768490008597 hypothetical protein; Provisional; Region: PRK02868 768490008598 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 768490008599 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 768490008600 Sulfate transporter family; Region: Sulfate_transp; pfam00916 768490008601 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 768490008602 intracellular septation protein A; Reviewed; Region: PRK00259 768490008603 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 768490008604 transport protein TonB; Provisional; Region: PRK10819 768490008605 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 768490008606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 768490008607 YciI-like protein; Reviewed; Region: PRK11370 768490008608 Head binding; Region: Head_binding; pfam09008 768490008609 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 768490008610 active site 768490008611 Mnt; Region: mnt; PHA01513 768490008612 Arc-like DNA binding domain; Region: Arc; pfam03869 768490008613 Regulatory protein Mnt; Region: Repressor_Mnt; pfam11423 768490008614 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 768490008615 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 768490008616 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768490008617 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768490008618 catalytic residue [active] 768490008619 Protein of unknown function (DUF2824); Region: DUF2824; cl10279 768490008620 Phage stabilisation protein; Region: Phage_stabilise; pfam11134 768490008621 P22 tail accessory factor; Region: P22_Tail-4; pfam11650 768490008622 coat protein; Region: PHA01511 768490008623 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 768490008624 Bacteriophage, scaffolding protein; Region: Phage-scaffold; pfam09306 768490008625 Terminase-like family; Region: Terminase_6; pfam03237 768490008626 Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565 768490008627 Terminase small subunit; Region: Terminase_2; pfam03592 768490008628 Protein of unknown function (DUF2560); Region: DUF2560; cl10280 768490008629 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 768490008630 Predicted chitinase [General function prediction only]; Region: COG3179 768490008631 catalytic residue [active] 768490008632 Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106 768490008633 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 768490008634 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 768490008635 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 768490008636 nucleotide binding site [chemical binding]; other site 768490008637 Virulence-associated protein E; Region: VirE; pfam05272 768490008638 putative Cro-like protein; Region: PHA00542 768490008639 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768490008640 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768490008641 sequence-specific DNA binding site [nucleotide binding]; other site 768490008642 salt bridge; other site 768490008643 Predicted transcriptional regulator [Transcription]; Region: COG2932 768490008644 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 768490008645 Catalytic site [active] 768490008646 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 768490008647 hypothetical protein; Provisional; Region: PRK09946 768490008648 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 768490008649 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 768490008650 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 768490008651 active site 768490008652 substrate binding site [chemical binding]; other site 768490008653 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 768490008654 active site 768490008655 DNA binding site [nucleotide binding] 768490008656 catalytic site [active] 768490008657 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 768490008658 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 768490008659 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 768490008660 ATP binding site [chemical binding]; other site 768490008661 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768490008662 nucleotide binding region [chemical binding]; other site 768490008663 ATP-binding site [chemical binding]; other site 768490008664 integrase; Provisional; Region: PRK09692 768490008665 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 768490008666 active site 768490008667 Int/Topo IB signature motif; other site 768490008668 KTSC domain; Region: KTSC; pfam13619 768490008669 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768490008670 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768490008671 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 768490008672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490008673 putative substrate translocation pore; other site 768490008674 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 768490008675 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 768490008676 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 768490008677 putative active site [active] 768490008678 catalytic site [active] 768490008679 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 768490008680 putative active site [active] 768490008681 catalytic site [active] 768490008682 dsDNA-mimic protein; Reviewed; Region: PRK05094 768490008683 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 768490008684 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768490008685 Walker A/P-loop; other site 768490008686 ATP binding site [chemical binding]; other site 768490008687 Q-loop/lid; other site 768490008688 ABC transporter signature motif; other site 768490008689 Walker B; other site 768490008690 D-loop; other site 768490008691 H-loop/switch region; other site 768490008692 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 768490008693 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 768490008694 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768490008695 Walker A/P-loop; other site 768490008696 ATP binding site [chemical binding]; other site 768490008697 Q-loop/lid; other site 768490008698 ABC transporter signature motif; other site 768490008699 Walker B; other site 768490008700 D-loop; other site 768490008701 H-loop/switch region; other site 768490008702 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768490008703 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 768490008704 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 768490008705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490008706 dimer interface [polypeptide binding]; other site 768490008707 conserved gate region; other site 768490008708 ABC-ATPase subunit interface; other site 768490008709 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 768490008710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490008711 dimer interface [polypeptide binding]; other site 768490008712 conserved gate region; other site 768490008713 putative PBP binding loops; other site 768490008714 ABC-ATPase subunit interface; other site 768490008715 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 768490008716 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 768490008717 peptide binding site [polypeptide binding]; other site 768490008718 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 768490008719 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 768490008720 peptide binding site [polypeptide binding]; other site 768490008721 hypothetical protein; Provisional; Region: PRK11111 768490008722 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 768490008723 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 768490008724 putative catalytic cysteine [active] 768490008725 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 768490008726 putative active site [active] 768490008727 metal binding site [ion binding]; metal-binding site 768490008728 thymidine kinase; Provisional; Region: PRK04296 768490008729 Uncharacterized conserved protein (DUF2217); Region: DUF2217; pfam10265 768490008730 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 768490008731 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 768490008732 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768490008733 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 768490008734 putative NAD(P) binding site [chemical binding]; other site 768490008735 active site 768490008736 putative substrate binding site [chemical binding]; other site 768490008737 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 768490008738 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 768490008739 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 768490008740 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 768490008741 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 768490008742 active site 768490008743 tetramer interface; other site 768490008744 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490008745 active site 768490008746 response regulator of RpoS; Provisional; Region: PRK10693 768490008747 phosphorylation site [posttranslational modification] 768490008748 intermolecular recognition site; other site 768490008749 dimerization interface [polypeptide binding]; other site 768490008750 hypothetical protein; Provisional; Region: PRK10279 768490008751 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 768490008752 nucleophile elbow; other site 768490008753 SEC-C motif; Region: SEC-C; pfam02810 768490008754 hypothetical protein; Provisional; Region: PRK04233 768490008755 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 768490008756 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 768490008757 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 768490008758 putative active site [active] 768490008759 putative substrate binding site [chemical binding]; other site 768490008760 putative cosubstrate binding site; other site 768490008761 catalytic site [active] 768490008762 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 768490008763 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 768490008764 putative catalytic site [active] 768490008765 putative phosphate binding site [ion binding]; other site 768490008766 active site 768490008767 metal binding site A [ion binding]; metal-binding site 768490008768 DNA binding site [nucleotide binding] 768490008769 putative AP binding site [nucleotide binding]; other site 768490008770 putative metal binding site B [ion binding]; other site 768490008771 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 768490008772 active site 768490008773 8-oxo-dGMP binding site [chemical binding]; other site 768490008774 nudix motif; other site 768490008775 metal binding site [ion binding]; metal-binding site 768490008776 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 768490008777 DNA topoisomerase III; Provisional; Region: PRK07726 768490008778 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 768490008779 active site 768490008780 putative interdomain interaction site [polypeptide binding]; other site 768490008781 putative metal-binding site [ion binding]; other site 768490008782 putative nucleotide binding site [chemical binding]; other site 768490008783 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 768490008784 domain I; other site 768490008785 DNA binding groove [nucleotide binding] 768490008786 phosphate binding site [ion binding]; other site 768490008787 domain II; other site 768490008788 domain III; other site 768490008789 nucleotide binding site [chemical binding]; other site 768490008790 catalytic site [active] 768490008791 domain IV; other site 768490008792 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 768490008793 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 768490008794 active site residue [active] 768490008795 selenophosphate synthetase; Provisional; Region: PRK00943 768490008796 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 768490008797 dimerization interface [polypeptide binding]; other site 768490008798 putative ATP binding site [chemical binding]; other site 768490008799 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 768490008800 putative FMN binding site [chemical binding]; other site 768490008801 protease 4; Provisional; Region: PRK10949 768490008802 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 768490008803 tandem repeat interface [polypeptide binding]; other site 768490008804 oligomer interface [polypeptide binding]; other site 768490008805 active site residues [active] 768490008806 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 768490008807 tandem repeat interface [polypeptide binding]; other site 768490008808 oligomer interface [polypeptide binding]; other site 768490008809 active site residues [active] 768490008810 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 768490008811 active site 768490008812 homodimer interface [polypeptide binding]; other site 768490008813 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 768490008814 Isochorismatase family; Region: Isochorismatase; pfam00857 768490008815 catalytic triad [active] 768490008816 metal binding site [ion binding]; metal-binding site 768490008817 conserved cis-peptide bond; other site 768490008818 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 768490008819 Glyco_18 domain; Region: Glyco_18; smart00636 768490008820 active site 768490008821 Protein of unknown function (DUF1315); Region: DUF1315; pfam07023 768490008822 methionine sulfoxide reductase B; Provisional; Region: PRK00222 768490008823 SelR domain; Region: SelR; pfam01641 768490008824 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 768490008825 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 768490008826 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 768490008827 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 768490008828 active site 768490008829 phosphate binding residues; other site 768490008830 catalytic residues [active] 768490008831 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 768490008832 PrkA family serine protein kinase; Provisional; Region: PRK15455 768490008833 AAA ATPase domain; Region: AAA_16; pfam13191 768490008834 Walker A motif; other site 768490008835 ATP binding site [chemical binding]; other site 768490008836 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 768490008837 hypothetical protein; Provisional; Region: PRK05325 768490008838 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768490008839 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490008840 Coenzyme A binding pocket [chemical binding]; other site 768490008841 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 768490008842 intracellular protease, PfpI family; Region: PfpI; TIGR01382 768490008843 conserved cys residue [active] 768490008844 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 768490008845 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 768490008846 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 768490008847 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768490008848 N-terminal plug; other site 768490008849 ligand-binding site [chemical binding]; other site 768490008850 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768490008851 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 768490008852 Walker A/P-loop; other site 768490008853 ATP binding site [chemical binding]; other site 768490008854 Q-loop/lid; other site 768490008855 ABC transporter signature motif; other site 768490008856 Walker B; other site 768490008857 D-loop; other site 768490008858 H-loop/switch region; other site 768490008859 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 768490008860 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768490008861 Walker A/P-loop; other site 768490008862 ATP binding site [chemical binding]; other site 768490008863 Q-loop/lid; other site 768490008864 ABC transporter signature motif; other site 768490008865 Walker B; other site 768490008866 D-loop; other site 768490008867 H-loop/switch region; other site 768490008868 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768490008869 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 768490008870 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 768490008871 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 768490008872 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 768490008873 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 768490008874 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 768490008875 active site 768490008876 substrate binding site [chemical binding]; other site 768490008877 catalytic site [active] 768490008878 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490008879 putative substrate translocation pore; other site 768490008880 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768490008881 alanine racemase; Reviewed; Region: dadX; PRK03646 768490008882 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 768490008883 active site 768490008884 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768490008885 substrate binding site [chemical binding]; other site 768490008886 catalytic residues [active] 768490008887 dimer interface [polypeptide binding]; other site 768490008888 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 768490008889 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768490008890 hydroxyglutarate oxidase; Provisional; Region: PRK11728 768490008891 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 768490008892 active site 768490008893 catalytic triad [active] 768490008894 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 768490008895 Baseplate J-like protein; Region: Baseplate_J; cl01294 768490008896 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 768490008897 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 768490008898 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768490008899 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768490008900 catalytic residue [active] 768490008901 Protein of unknown function (DUF3277); Region: DUF3277; pfam11681 768490008902 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 768490008903 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 768490008904 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834 768490008905 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 768490008906 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 768490008907 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 768490008908 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 768490008909 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 768490008910 Terminase small subunit; Region: Terminase_2; pfam03592 768490008911 Predicted chitinase [General function prediction only]; Region: COG3179 768490008912 catalytic residue [active] 768490008913 Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106 768490008914 Poxvirus G5 protein; Region: Pox_G5; pfam04599 768490008915 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 768490008916 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 768490008917 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 768490008918 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 768490008919 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 768490008920 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 768490008921 cofactor binding site; other site 768490008922 DNA binding site [nucleotide binding] 768490008923 substrate interaction site [chemical binding]; other site 768490008924 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 768490008925 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 768490008926 replicative DNA helicase; Region: DnaB; TIGR00665 768490008927 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 768490008928 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 768490008929 Walker A motif; other site 768490008930 ATP binding site [chemical binding]; other site 768490008931 Walker B motif; other site 768490008932 DNA binding loops [nucleotide binding] 768490008933 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 768490008934 transcriptional repressor DicA; Reviewed; Region: PRK09706 768490008935 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768490008936 non-specific DNA binding site [nucleotide binding]; other site 768490008937 salt bridge; other site 768490008938 sequence-specific DNA binding site [nucleotide binding]; other site 768490008939 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 768490008940 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 768490008941 Excisionase-like protein; Region: Exc; pfam07825 768490008942 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 768490008943 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768490008944 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 768490008945 dimer interface [polypeptide binding]; other site 768490008946 active site 768490008947 Int/Topo IB signature motif; other site 768490008948 SpoVR family protein; Provisional; Region: PRK11767 768490008949 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 768490008950 fatty acid metabolism regulator; Provisional; Region: PRK04984 768490008951 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768490008952 DNA-binding site [nucleotide binding]; DNA binding site 768490008953 FadR C-terminal domain; Region: FadR_C; pfam07840 768490008954 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 768490008955 disulfide bond formation protein B; Provisional; Region: PRK01749 768490008956 hypothetical protein; Provisional; Region: PRK05170 768490008957 CsbD-like; Region: CsbD; cl17424 768490008958 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 768490008959 hypothetical protein; Provisional; Region: PRK10691 768490008960 Transglycosylase SLT domain; Region: SLT_2; pfam13406 768490008961 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768490008962 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768490008963 catalytic residue [active] 768490008964 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 768490008965 septum formation inhibitor; Reviewed; Region: minC; PRK03511 768490008966 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 768490008967 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 768490008968 cell division inhibitor MinD; Provisional; Region: PRK10818 768490008969 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 768490008970 Switch I; other site 768490008971 Switch II; other site 768490008972 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 768490008973 ribonuclease D; Provisional; Region: PRK10829 768490008974 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 768490008975 catalytic site [active] 768490008976 putative active site [active] 768490008977 putative substrate binding site [chemical binding]; other site 768490008978 Helicase and RNase D C-terminal; Region: HRDC; smart00341 768490008979 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 768490008980 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 768490008981 acyl-activating enzyme (AAE) consensus motif; other site 768490008982 putative AMP binding site [chemical binding]; other site 768490008983 putative active site [active] 768490008984 putative CoA binding site [chemical binding]; other site 768490008985 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 768490008986 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 768490008987 Glycoprotease family; Region: Peptidase_M22; pfam00814 768490008988 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 768490008989 DEAD/DEAH box helicase; Region: DEAD; pfam00270 768490008990 ATP binding site [chemical binding]; other site 768490008991 DEAD_2; Region: DEAD_2; pfam06733 768490008992 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 768490008993 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 768490008994 homotrimer interaction site [polypeptide binding]; other site 768490008995 putative active site [active] 768490008996 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 768490008997 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 768490008998 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 768490008999 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 768490009000 active site 768490009001 intersubunit interface [polypeptide binding]; other site 768490009002 catalytic residue [active] 768490009003 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 768490009004 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 768490009005 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 768490009006 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 768490009007 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768490009008 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768490009009 putative active site [active] 768490009010 pyruvate kinase; Provisional; Region: PRK05826 768490009011 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 768490009012 domain interfaces; other site 768490009013 active site 768490009014 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 768490009015 Leucine-rich repeats; other site 768490009016 Substrate binding site [chemical binding]; other site 768490009017 Leucine rich repeat; Region: LRR_8; pfam13855 768490009018 Leucine rich repeat; Region: LRR_8; pfam13855 768490009019 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 768490009020 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 768490009021 putative acyl-acceptor binding pocket; other site 768490009022 putative peptidase; Provisional; Region: PRK11649 768490009023 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 768490009024 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768490009025 Peptidase family M23; Region: Peptidase_M23; pfam01551 768490009026 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 768490009027 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 768490009028 metal binding site [ion binding]; metal-binding site 768490009029 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 768490009030 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 768490009031 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768490009032 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 768490009033 ABC-ATPase subunit interface; other site 768490009034 dimer interface [polypeptide binding]; other site 768490009035 putative PBP binding regions; other site 768490009036 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 768490009037 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768490009038 Walker A motif; other site 768490009039 ATP binding site [chemical binding]; other site 768490009040 Walker B motif; other site 768490009041 arginine finger; other site 768490009042 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 768490009043 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 768490009044 RuvA N terminal domain; Region: RuvA_N; pfam01330 768490009045 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 768490009046 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 768490009047 active site 768490009048 putative DNA-binding cleft [nucleotide binding]; other site 768490009049 dimer interface [polypeptide binding]; other site 768490009050 hypothetical protein; Validated; Region: PRK00110 768490009051 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 768490009052 nudix motif; other site 768490009053 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 768490009054 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 768490009055 dimer interface [polypeptide binding]; other site 768490009056 anticodon binding site; other site 768490009057 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 768490009058 homodimer interface [polypeptide binding]; other site 768490009059 motif 1; other site 768490009060 active site 768490009061 motif 2; other site 768490009062 GAD domain; Region: GAD; pfam02938 768490009063 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 768490009064 active site 768490009065 motif 3; other site 768490009066 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 768490009067 Isochorismatase family; Region: Isochorismatase; pfam00857 768490009068 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 768490009069 catalytic triad [active] 768490009070 conserved cis-peptide bond; other site 768490009071 hypothetical protein; Provisional; Region: PRK10302 768490009072 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 768490009073 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490009074 S-adenosylmethionine binding site [chemical binding]; other site 768490009075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490009076 S-adenosylmethionine binding site [chemical binding]; other site 768490009077 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 768490009078 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 768490009079 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 768490009080 copper homeostasis protein CutC; Provisional; Region: PRK11572 768490009081 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 768490009082 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768490009083 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490009084 homodimer interface [polypeptide binding]; other site 768490009085 catalytic residue [active] 768490009086 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 768490009087 putative metal binding site [ion binding]; other site 768490009088 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 768490009089 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 768490009090 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 768490009091 active site 768490009092 HIGH motif; other site 768490009093 KMSK motif region; other site 768490009094 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 768490009095 tRNA binding surface [nucleotide binding]; other site 768490009096 anticodon binding site; other site 768490009097 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 768490009098 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 768490009099 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768490009100 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768490009101 hypothetical protein; Provisional; Region: PRK11239 768490009102 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 768490009103 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 768490009104 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 768490009105 multidrug resistance protein MdtH; Provisional; Region: PRK11646 768490009106 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490009107 putative substrate translocation pore; other site 768490009108 glutaredoxin 2; Provisional; Region: PRK10387 768490009109 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 768490009110 C-terminal domain interface [polypeptide binding]; other site 768490009111 GSH binding site (G-site) [chemical binding]; other site 768490009112 catalytic residues [active] 768490009113 putative dimer interface [polypeptide binding]; other site 768490009114 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 768490009115 N-terminal domain interface [polypeptide binding]; other site 768490009116 ABC1 family; Region: ABC1; cl17513 768490009117 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 768490009118 lipoprotein; Provisional; Region: PRK10598 768490009119 hypothetical protein; Provisional; Region: PRK13680 768490009120 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 768490009121 YebG protein; Region: YebG; pfam07130 768490009122 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 768490009123 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 768490009124 ATP binding site [chemical binding]; other site 768490009125 Mg++ binding site [ion binding]; other site 768490009126 motif III; other site 768490009127 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768490009128 nucleotide binding region [chemical binding]; other site 768490009129 ATP-binding site [chemical binding]; other site 768490009130 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 768490009131 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 768490009132 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768490009133 ATP-grasp domain; Region: ATP-grasp; pfam02222 768490009134 hypothetical protein; Provisional; Region: PRK05114 768490009135 putative glycosyl transferase; Provisional; Region: PRK10073 768490009136 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 768490009137 active site 768490009138 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 768490009139 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 768490009140 chorismate binding enzyme; Region: Chorismate_bind; cl10555 768490009141 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 768490009142 putative active site [active] 768490009143 putative CoA binding site [chemical binding]; other site 768490009144 nudix motif; other site 768490009145 metal binding site [ion binding]; metal-binding site 768490009146 L-serine deaminase; Provisional; Region: PRK15023 768490009147 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 768490009148 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 768490009149 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 768490009150 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768490009151 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 768490009152 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 768490009153 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 768490009154 Transporter associated domain; Region: CorC_HlyC; smart01091 768490009155 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 768490009156 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 768490009157 active pocket/dimerization site; other site 768490009158 active site 768490009159 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 768490009160 active site 768490009161 phosphorylation site [posttranslational modification] 768490009162 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 768490009163 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 768490009164 hypothetical protein; Provisional; Region: PRK02913 768490009165 Domain of unknown function DUF; Region: DUF204; pfam02659 768490009166 Domain of unknown function DUF; Region: DUF204; pfam02659 768490009167 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 768490009168 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490009169 putative substrate translocation pore; other site 768490009170 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768490009171 dimerization interface [polypeptide binding]; other site 768490009172 putative DNA binding site [nucleotide binding]; other site 768490009173 Transcriptional regulators [Transcription]; Region: MarR; COG1846 768490009174 putative Zn2+ binding site [ion binding]; other site 768490009175 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 768490009176 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490009177 S-adenosylmethionine binding site [chemical binding]; other site 768490009178 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 768490009179 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 768490009180 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768490009181 DNA-binding site [nucleotide binding]; DNA binding site 768490009182 RNA-binding motif; other site 768490009183 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 768490009184 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 768490009185 aromatic amino acid transporter; Provisional; Region: PRK10238 768490009186 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 768490009187 Protein of unknown function (DUF2591); Region: DUF2591; pfam10765 768490009188 FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244 768490009189 dimer interface [polypeptide binding]; other site 768490009190 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768490009191 Mn binding site [ion binding]; other site 768490009192 K binding site [ion binding]; other site 768490009193 YebO-like protein; Region: YebO; pfam13974 768490009194 YobH-like protein; Region: YobH; pfam13996 768490009195 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 768490009196 YccJ-like protein; Region: YccJ; cl08091 768490009197 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 768490009198 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490009199 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 768490009200 Pirin; Region: Pirin; pfam02678 768490009201 Pirin-related protein [General function prediction only]; Region: COG1741 768490009202 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 768490009203 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 768490009204 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768490009205 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 768490009206 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 768490009207 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 768490009208 trimer interface [polypeptide binding]; other site 768490009209 eyelet of channel; other site 768490009210 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 768490009211 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 768490009212 putative active site [active] 768490009213 Zn binding site [ion binding]; other site 768490009214 succinylarginine dihydrolase; Provisional; Region: PRK13281 768490009215 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 768490009216 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 768490009217 NAD(P) binding site [chemical binding]; other site 768490009218 catalytic residues [active] 768490009219 arginine succinyltransferase; Provisional; Region: PRK10456 768490009220 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 768490009221 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 768490009222 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768490009223 inhibitor-cofactor binding pocket; inhibition site 768490009224 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490009225 catalytic residue [active] 768490009226 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 768490009227 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 768490009228 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 768490009229 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768490009230 Walker A/P-loop; other site 768490009231 ATP binding site [chemical binding]; other site 768490009232 Q-loop/lid; other site 768490009233 ABC transporter signature motif; other site 768490009234 Walker B; other site 768490009235 D-loop; other site 768490009236 H-loop/switch region; other site 768490009237 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 768490009238 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768490009239 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 768490009240 Walker A/P-loop; other site 768490009241 ATP binding site [chemical binding]; other site 768490009242 Q-loop/lid; other site 768490009243 ABC transporter signature motif; other site 768490009244 Walker B; other site 768490009245 D-loop; other site 768490009246 H-loop/switch region; other site 768490009247 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 768490009248 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 768490009249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490009250 dimer interface [polypeptide binding]; other site 768490009251 conserved gate region; other site 768490009252 putative PBP binding loops; other site 768490009253 ABC-ATPase subunit interface; other site 768490009254 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 768490009255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490009256 dimer interface [polypeptide binding]; other site 768490009257 conserved gate region; other site 768490009258 putative PBP binding loops; other site 768490009259 ABC-ATPase subunit interface; other site 768490009260 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 768490009261 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 768490009262 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768490009263 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768490009264 DNA-binding site [nucleotide binding]; DNA binding site 768490009265 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768490009266 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490009267 homodimer interface [polypeptide binding]; other site 768490009268 catalytic residue [active] 768490009269 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 768490009270 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 768490009271 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 768490009272 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 768490009273 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 768490009274 Fatty acid desaturase; Region: FA_desaturase; pfam00487 768490009275 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 768490009276 putative di-iron ligands [ion binding]; other site 768490009277 Fatty acid desaturase; Region: FA_desaturase; pfam00487 768490009278 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 768490009279 putative di-iron ligands [ion binding]; other site 768490009280 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 768490009281 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 768490009282 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 768490009283 active site 768490009284 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 768490009285 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 768490009286 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 768490009287 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 768490009288 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768490009289 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768490009290 NAD(P) binding site [chemical binding]; other site 768490009291 active site 768490009292 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 768490009293 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 768490009294 dimer interface [polypeptide binding]; other site 768490009295 active site 768490009296 CoA binding pocket [chemical binding]; other site 768490009297 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 768490009298 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 768490009299 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 768490009300 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 768490009301 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 768490009302 [4Fe-4S] binding site [ion binding]; other site 768490009303 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 768490009304 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 768490009305 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 768490009306 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 768490009307 molybdopterin cofactor binding site; other site 768490009308 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 768490009309 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 768490009310 active site 768490009311 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 768490009312 active site 768490009313 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 768490009314 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 768490009315 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 768490009316 active site 768490009317 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 768490009318 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 768490009319 putative ADP-binding pocket [chemical binding]; other site 768490009320 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768490009321 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 768490009322 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 768490009323 active site 768490009324 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 768490009325 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 768490009326 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 768490009327 tyrosine kinase; Provisional; Region: PRK11519 768490009328 Chain length determinant protein; Region: Wzz; pfam02706 768490009329 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 768490009330 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 768490009331 Nucleotide binding site [chemical binding]; other site 768490009332 DTAP/Switch II; other site 768490009333 Switch I; other site 768490009334 polysaccharide export protein Wza; Provisional; Region: PRK15078 768490009335 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 768490009336 SLBB domain; Region: SLBB; pfam10531 768490009337 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 768490009338 Mg++ binding site [ion binding]; other site 768490009339 putative catalytic motif [active] 768490009340 substrate binding site [chemical binding]; other site 768490009341 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768490009342 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 768490009343 NAD(P) binding site [chemical binding]; other site 768490009344 active site 768490009345 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768490009346 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768490009347 DNA binding site [nucleotide binding] 768490009348 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 768490009349 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 768490009350 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 768490009351 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768490009352 dimerization interface [polypeptide binding]; other site 768490009353 Histidine kinase; Region: HisKA_3; pfam07730 768490009354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490009355 ATP binding site [chemical binding]; other site 768490009356 Mg2+ binding site [ion binding]; other site 768490009357 G-X-G motif; other site 768490009358 transcriptional regulator NarL; Provisional; Region: PRK10651 768490009359 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490009360 active site 768490009361 phosphorylation site [posttranslational modification] 768490009362 intermolecular recognition site; other site 768490009363 dimerization interface [polypeptide binding]; other site 768490009364 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768490009365 DNA binding residues [nucleotide binding] 768490009366 dimerization interface [polypeptide binding]; other site 768490009367 putative invasin; Provisional; Region: PRK10177 768490009368 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 768490009369 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 768490009370 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 768490009371 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 768490009372 substrate binding site [chemical binding]; other site 768490009373 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 768490009374 active site 768490009375 SAM binding site [chemical binding]; other site 768490009376 homodimer interface [polypeptide binding]; other site 768490009377 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 768490009378 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 768490009379 [4Fe-4S] binding site [ion binding]; other site 768490009380 molybdopterin cofactor binding site; other site 768490009381 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 768490009382 molybdopterin cofactor binding site; other site 768490009383 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 768490009384 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 768490009385 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768490009386 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768490009387 nitrite reductase subunit NirD; Provisional; Region: PRK14989 768490009388 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768490009389 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 768490009390 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 768490009391 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 768490009392 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 768490009393 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 768490009394 Walker A/P-loop; other site 768490009395 ATP binding site [chemical binding]; other site 768490009396 Q-loop/lid; other site 768490009397 ABC transporter signature motif; other site 768490009398 Walker B; other site 768490009399 D-loop; other site 768490009400 H-loop/switch region; other site 768490009401 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 768490009402 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490009403 dimer interface [polypeptide binding]; other site 768490009404 conserved gate region; other site 768490009405 putative PBP binding loops; other site 768490009406 ABC-ATPase subunit interface; other site 768490009407 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 768490009408 NMT1-like family; Region: NMT1_2; pfam13379 768490009409 Nitrate and nitrite sensing; Region: NIT; pfam08376 768490009410 ANTAR domain; Region: ANTAR; pfam03861 768490009411 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 768490009412 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 768490009413 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768490009414 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768490009415 Walker A/P-loop; other site 768490009416 ATP binding site [chemical binding]; other site 768490009417 Q-loop/lid; other site 768490009418 ABC transporter signature motif; other site 768490009419 Walker B; other site 768490009420 D-loop; other site 768490009421 H-loop/switch region; other site 768490009422 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768490009423 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 768490009424 Walker A/P-loop; other site 768490009425 ATP binding site [chemical binding]; other site 768490009426 Q-loop/lid; other site 768490009427 ABC transporter signature motif; other site 768490009428 Walker B; other site 768490009429 D-loop; other site 768490009430 H-loop/switch region; other site 768490009431 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 768490009432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490009433 dimer interface [polypeptide binding]; other site 768490009434 conserved gate region; other site 768490009435 putative PBP binding loops; other site 768490009436 ABC-ATPase subunit interface; other site 768490009437 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 768490009438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490009439 dimer interface [polypeptide binding]; other site 768490009440 conserved gate region; other site 768490009441 putative PBP binding loops; other site 768490009442 ABC-ATPase subunit interface; other site 768490009443 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 768490009444 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 768490009445 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 768490009446 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 768490009447 substrate binding site [chemical binding]; other site 768490009448 dimerization interface [polypeptide binding]; other site 768490009449 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 768490009450 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 768490009451 putative active site pocket [active] 768490009452 dimerization interface [polypeptide binding]; other site 768490009453 putative catalytic residue [active] 768490009454 cation transport regulator; Reviewed; Region: chaB; PRK09582 768490009455 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 768490009456 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 768490009457 FAD binding pocket [chemical binding]; other site 768490009458 FAD binding motif [chemical binding]; other site 768490009459 phosphate binding motif [ion binding]; other site 768490009460 NAD binding pocket [chemical binding]; other site 768490009461 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 768490009462 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 768490009463 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 768490009464 hypothetical protein; Provisional; Region: PRK10536 768490009465 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 768490009466 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 768490009467 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768490009468 N-terminal plug; other site 768490009469 ligand-binding site [chemical binding]; other site 768490009470 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 768490009471 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 768490009472 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 768490009473 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 768490009474 Imelysin; Region: Peptidase_M75; pfam09375 768490009475 Iron permease FTR1 family; Region: FTR1; cl00475 768490009476 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 768490009477 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 768490009478 Na binding site [ion binding]; other site 768490009479 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 768490009480 Predicted transcriptional regulator [Transcription]; Region: COG3905 768490009481 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 768490009482 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 768490009483 Glutamate binding site [chemical binding]; other site 768490009484 NAD binding site [chemical binding]; other site 768490009485 catalytic residues [active] 768490009486 YcfA-like protein; Region: YcfA; pfam07927 768490009487 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 768490009488 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 768490009489 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 768490009490 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 768490009491 Walker A/P-loop; other site 768490009492 ATP binding site [chemical binding]; other site 768490009493 Q-loop/lid; other site 768490009494 ABC transporter signature motif; other site 768490009495 Walker B; other site 768490009496 D-loop; other site 768490009497 H-loop/switch region; other site 768490009498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490009499 dimer interface [polypeptide binding]; other site 768490009500 conserved gate region; other site 768490009501 putative PBP binding loops; other site 768490009502 ABC-ATPase subunit interface; other site 768490009503 cystine transporter subunit; Provisional; Region: PRK11260 768490009504 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768490009505 substrate binding pocket [chemical binding]; other site 768490009506 membrane-bound complex binding site; other site 768490009507 hinge residues; other site 768490009508 D-cysteine desulfhydrase; Validated; Region: PRK03910 768490009509 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 768490009510 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490009511 catalytic residue [active] 768490009512 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 768490009513 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 768490009514 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768490009515 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 768490009516 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768490009517 DNA binding residues [nucleotide binding] 768490009518 flagellin; Validated; Region: PRK06819 768490009519 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 768490009520 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 768490009521 flagellar capping protein; Reviewed; Region: fliD; PRK08032 768490009522 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 768490009523 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 768490009524 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 768490009525 flagellar protein FliS; Validated; Region: fliS; PRK05685 768490009526 Flagellar protein FliT; Region: FliT; cl05125 768490009527 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768490009528 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490009529 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 768490009530 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 768490009531 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 768490009532 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 768490009533 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 768490009534 FliG C-terminal domain; Region: FliG_C; pfam01706 768490009535 flagellar assembly protein H; Validated; Region: fliH; PRK05687 768490009536 Flagellar assembly protein FliH; Region: FliH; pfam02108 768490009537 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 768490009538 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 768490009539 Walker A motif/ATP binding site; other site 768490009540 Walker B motif; other site 768490009541 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 768490009542 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 768490009543 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 768490009544 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 768490009545 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 768490009546 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 768490009547 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 768490009548 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 768490009549 Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190 768490009550 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 768490009551 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 768490009552 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 768490009553 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 768490009554 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 768490009555 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 768490009556 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 768490009557 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 768490009558 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 768490009559 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 768490009560 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 768490009561 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 768490009562 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 768490009563 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 768490009564 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 768490009565 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 768490009566 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 768490009567 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 768490009568 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 768490009569 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 768490009570 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 768490009571 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 768490009572 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 768490009573 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 768490009574 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 768490009575 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 768490009576 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 768490009577 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 768490009578 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 768490009579 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 768490009580 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 768490009581 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 768490009582 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 768490009583 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 768490009584 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 768490009585 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 768490009586 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 768490009587 FlgN protein; Region: FlgN; cl09176 768490009588 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 768490009589 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 768490009590 Predicted transcriptional regulator [Transcription]; Region: COG2944 768490009591 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768490009592 non-specific DNA binding site [nucleotide binding]; other site 768490009593 salt bridge; other site 768490009594 sequence-specific DNA binding site [nucleotide binding]; other site 768490009595 Flagellar protein FlhE; Region: FlhE; pfam06366 768490009596 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 768490009597 FHIPEP family; Region: FHIPEP; pfam00771 768490009598 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK12468 768490009599 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 768490009600 chemotaxis regulator CheZ; Provisional; Region: PRK11166 768490009601 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 768490009602 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490009603 active site 768490009604 phosphorylation site [posttranslational modification] 768490009605 intermolecular recognition site; other site 768490009606 dimerization interface [polypeptide binding]; other site 768490009607 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 768490009608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490009609 active site 768490009610 phosphorylation site [posttranslational modification] 768490009611 intermolecular recognition site; other site 768490009612 dimerization interface [polypeptide binding]; other site 768490009613 CheB methylesterase; Region: CheB_methylest; pfam01339 768490009614 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 768490009615 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 768490009616 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490009617 methyl-accepting protein IV; Provisional; Region: PRK09793 768490009618 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 768490009619 dimer interface [polypeptide binding]; other site 768490009620 ligand binding site [chemical binding]; other site 768490009621 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768490009622 dimerization interface [polypeptide binding]; other site 768490009623 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768490009624 dimer interface [polypeptide binding]; other site 768490009625 putative CheW interface [polypeptide binding]; other site 768490009626 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 768490009627 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 768490009628 dimer interface [polypeptide binding]; other site 768490009629 ligand binding site [chemical binding]; other site 768490009630 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768490009631 dimerization interface [polypeptide binding]; other site 768490009632 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768490009633 dimer interface [polypeptide binding]; other site 768490009634 putative CheW interface [polypeptide binding]; other site 768490009635 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 768490009636 putative CheA interaction surface; other site 768490009637 chemotaxis protein CheA; Provisional; Region: PRK10547 768490009638 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 768490009639 putative binding surface; other site 768490009640 active site 768490009641 CheY binding; Region: CheY-binding; pfam09078 768490009642 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 768490009643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490009644 ATP binding site [chemical binding]; other site 768490009645 Mg2+ binding site [ion binding]; other site 768490009646 G-X-G motif; other site 768490009647 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 768490009648 flagellar motor protein MotB; Validated; Region: motB; PRK09041 768490009649 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 768490009650 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 768490009651 ligand binding site [chemical binding]; other site 768490009652 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 768490009653 flagellar motor protein MotA; Validated; Region: PRK09110 768490009654 transcriptional activator FlhC; Provisional; Region: PRK12722 768490009655 transcriptional activator FlhD; Provisional; Region: PRK02909 768490009656 Haemolysin expression modulating protein; Region: HHA; cl11501 768490009657 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 768490009658 Ligand Binding Site [chemical binding]; other site 768490009659 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 768490009660 Prostaglandin dehydrogenases; Region: PGDH; cd05288 768490009661 NAD(P) binding site [chemical binding]; other site 768490009662 substrate binding site [chemical binding]; other site 768490009663 dimer interface [polypeptide binding]; other site 768490009664 DNA gyrase inhibitor; Provisional; Region: PRK10016 768490009665 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 768490009666 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 768490009667 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 768490009668 active site 768490009669 DNA binding site [nucleotide binding] 768490009670 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 768490009671 Fungal chitosanase of glycosyl hydrolase group 75; Region: Glyco_hydro_75; pfam07335 768490009672 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 768490009673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490009674 putative substrate translocation pore; other site 768490009675 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 768490009676 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 768490009677 dimerization domain [polypeptide binding]; other site 768490009678 dimer interface [polypeptide binding]; other site 768490009679 catalytic residues [active] 768490009680 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 768490009681 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 768490009682 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 768490009683 Catalytic site [active] 768490009684 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 768490009685 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490009686 active site 768490009687 phosphorylation site [posttranslational modification] 768490009688 intermolecular recognition site; other site 768490009689 dimerization interface [polypeptide binding]; other site 768490009690 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768490009691 DNA binding residues [nucleotide binding] 768490009692 dimerization interface [polypeptide binding]; other site 768490009693 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 768490009694 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 768490009695 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 768490009696 Transmembrane secretion effector; Region: MFS_3; pfam05977 768490009697 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490009698 putative substrate translocation pore; other site 768490009699 DoxX; Region: DoxX; pfam07681 768490009700 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 768490009701 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 768490009702 active site 768490009703 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 768490009704 Isochorismatase family; Region: Isochorismatase; pfam00857 768490009705 catalytic triad [active] 768490009706 dimer interface [polypeptide binding]; other site 768490009707 conserved cis-peptide bond; other site 768490009708 Protein of unknown function (DUF1427); Region: DUF1427; cl01771 768490009709 Response regulator receiver domain; Region: Response_reg; pfam00072 768490009710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490009711 active site 768490009712 phosphorylation site [posttranslational modification] 768490009713 intermolecular recognition site; other site 768490009714 dimerization interface [polypeptide binding]; other site 768490009715 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 768490009716 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 768490009717 substrate binding site [chemical binding]; other site 768490009718 activation loop (A-loop); other site 768490009719 Predicted ATPase [General function prediction only]; Region: COG3899 768490009720 AAA ATPase domain; Region: AAA_16; pfam13191 768490009721 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 768490009722 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 768490009723 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768490009724 PAS fold; Region: PAS_3; pfam08447 768490009725 putative active site [active] 768490009726 heme pocket [chemical binding]; other site 768490009727 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768490009728 dimer interface [polypeptide binding]; other site 768490009729 phosphorylation site [posttranslational modification] 768490009730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490009731 ATP binding site [chemical binding]; other site 768490009732 Mg2+ binding site [ion binding]; other site 768490009733 G-X-G motif; other site 768490009734 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 768490009735 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 768490009736 Bacterial transcriptional regulator; Region: IclR; pfam01614 768490009737 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 768490009738 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 768490009739 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 768490009740 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 768490009741 dimer interface [polypeptide binding]; other site 768490009742 active site 768490009743 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 768490009744 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 768490009745 ArsC family; Region: ArsC; pfam03960 768490009746 catalytic residues [active] 768490009747 arsenical pump membrane protein; Provisional; Region: PRK15445 768490009748 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 768490009749 transmembrane helices; other site 768490009750 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768490009751 dimerization interface [polypeptide binding]; other site 768490009752 putative DNA binding site [nucleotide binding]; other site 768490009753 putative Zn2+ binding site [ion binding]; other site 768490009754 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 768490009755 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 768490009756 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490009757 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490009758 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768490009759 putative effector binding pocket; other site 768490009760 dimerization interface [polypeptide binding]; other site 768490009761 Protein of unknown function, DUF606; Region: DUF606; pfam04657 768490009762 Protein of unknown function, DUF606; Region: DUF606; pfam04657 768490009763 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 768490009764 magnesium-transporting ATPase; Provisional; Region: PRK15122 768490009765 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 768490009766 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768490009767 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 768490009768 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768490009769 motif II; other site 768490009770 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 768490009771 magnesium transport protein MgtC; Provisional; Region: PRK15385 768490009772 MgtC family; Region: MgtC; pfam02308 768490009773 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 768490009774 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 768490009775 CoA-transferase family III; Region: CoA_transf_3; pfam02515 768490009776 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768490009777 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490009778 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 768490009779 dimerization interface [polypeptide binding]; other site 768490009780 substrate binding pocket [chemical binding]; other site 768490009781 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 768490009782 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768490009783 catalytic residue [active] 768490009784 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 768490009785 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768490009786 DNA binding residues [nucleotide binding] 768490009787 dimerization interface [polypeptide binding]; other site 768490009788 hypothetical protein; Provisional; Region: PRK10708 768490009789 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768490009790 DNA-binding site [nucleotide binding]; DNA binding site 768490009791 RNA-binding motif; other site 768490009792 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 768490009793 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 768490009794 NAD(P) binding site [chemical binding]; other site 768490009795 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 768490009796 putative catalytic site [active] 768490009797 putative metal binding site [ion binding]; other site 768490009798 putative phosphate binding site [ion binding]; other site 768490009799 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 768490009800 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768490009801 NAD(P) binding site [chemical binding]; other site 768490009802 active site 768490009803 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490009804 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490009805 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768490009806 putative effector binding pocket; other site 768490009807 dimerization interface [polypeptide binding]; other site 768490009808 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 768490009809 hypothetical protein; Provisional; Region: PRK10457 768490009810 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490009811 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490009812 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 768490009813 putative effector binding pocket; other site 768490009814 putative dimerization interface [polypeptide binding]; other site 768490009815 short chain dehydrogenase; Provisional; Region: PRK12744 768490009816 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 768490009817 NADP binding site [chemical binding]; other site 768490009818 homodimer interface [polypeptide binding]; other site 768490009819 active site 768490009820 substrate binding site [chemical binding]; other site 768490009821 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 768490009822 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768490009823 dimer interface [polypeptide binding]; other site 768490009824 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768490009825 metal binding site [ion binding]; metal-binding site 768490009826 active site 768490009827 I-site; other site 768490009828 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 768490009829 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 768490009830 substrate binding site [chemical binding]; other site 768490009831 dimer interface [polypeptide binding]; other site 768490009832 NADP binding site [chemical binding]; other site 768490009833 catalytic residues [active] 768490009834 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 768490009835 substrate binding site [chemical binding]; other site 768490009836 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 768490009837 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 768490009838 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 768490009839 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 768490009840 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 768490009841 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 768490009842 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 768490009843 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 768490009844 FAD binding pocket [chemical binding]; other site 768490009845 FAD binding motif [chemical binding]; other site 768490009846 phosphate binding motif [ion binding]; other site 768490009847 beta-alpha-beta structure motif; other site 768490009848 NAD(p) ribose binding residues [chemical binding]; other site 768490009849 NAD binding pocket [chemical binding]; other site 768490009850 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 768490009851 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768490009852 catalytic loop [active] 768490009853 iron binding site [ion binding]; other site 768490009854 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 768490009855 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768490009856 substrate binding site [chemical binding]; other site 768490009857 oxyanion hole (OAH) forming residues; other site 768490009858 trimer interface [polypeptide binding]; other site 768490009859 enoyl-CoA hydratase; Provisional; Region: PRK08140 768490009860 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768490009861 substrate binding site [chemical binding]; other site 768490009862 oxyanion hole (OAH) forming residues; other site 768490009863 trimer interface [polypeptide binding]; other site 768490009864 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 768490009865 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 768490009866 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768490009867 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768490009868 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 768490009869 CoenzymeA binding site [chemical binding]; other site 768490009870 subunit interaction site [polypeptide binding]; other site 768490009871 PHB binding site; other site 768490009872 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 768490009873 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 768490009874 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 768490009875 active site 768490009876 AMP binding site [chemical binding]; other site 768490009877 homodimer interface [polypeptide binding]; other site 768490009878 acyl-activating enzyme (AAE) consensus motif; other site 768490009879 CoA binding site [chemical binding]; other site 768490009880 PaaX-like protein; Region: PaaX; pfam07848 768490009881 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 768490009882 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 768490009883 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 768490009884 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 768490009885 putative trimer interface [polypeptide binding]; other site 768490009886 putative metal binding site [ion binding]; other site 768490009887 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768490009888 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768490009889 DNA-binding site [nucleotide binding]; DNA binding site 768490009890 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768490009891 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490009892 homodimer interface [polypeptide binding]; other site 768490009893 catalytic residue [active] 768490009894 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 768490009895 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 768490009896 conserved cys residue [active] 768490009897 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490009898 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 768490009899 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 768490009900 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 768490009901 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 768490009902 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768490009903 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490009904 homodimer interface [polypeptide binding]; other site 768490009905 catalytic residue [active] 768490009906 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 768490009907 homotrimer interaction site [polypeptide binding]; other site 768490009908 putative active site [active] 768490009909 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768490009910 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 768490009911 LysR family transcriptional regulator; Provisional; Region: PRK14997 768490009912 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490009913 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 768490009914 putative effector binding pocket; other site 768490009915 putative dimerization interface [polypeptide binding]; other site 768490009916 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 768490009917 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 768490009918 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 768490009919 putative N-terminal domain interface [polypeptide binding]; other site 768490009920 putative dimer interface [polypeptide binding]; other site 768490009921 putative substrate binding pocket (H-site) [chemical binding]; other site 768490009922 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 768490009923 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 768490009924 Glycogen synthesis protein; Region: GlgS; cl11663 768490009925 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 768490009926 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 768490009927 tetramerization interface [polypeptide binding]; other site 768490009928 NAD(P) binding site [chemical binding]; other site 768490009929 catalytic residues [active] 768490009930 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 768490009931 dimer interface [polypeptide binding]; other site 768490009932 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768490009933 ligand binding site [chemical binding]; other site 768490009934 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 768490009935 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490009936 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490009937 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 768490009938 putative effector binding pocket; other site 768490009939 putative dimerization interface [polypeptide binding]; other site 768490009940 Condensation domain; Region: Condensation; pfam00668 768490009941 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 768490009942 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 768490009943 acyl-activating enzyme (AAE) consensus motif; other site 768490009944 AMP binding site [chemical binding]; other site 768490009945 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768490009946 Condensation domain; Region: Condensation; pfam00668 768490009947 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 768490009948 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 768490009949 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 768490009950 acyl-activating enzyme (AAE) consensus motif; other site 768490009951 AMP binding site [chemical binding]; other site 768490009952 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768490009953 Condensation domain; Region: Condensation; pfam00668 768490009954 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 768490009955 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 768490009956 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 768490009957 acyl-activating enzyme (AAE) consensus motif; other site 768490009958 AMP binding site [chemical binding]; other site 768490009959 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768490009960 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 768490009961 Uncharacterized membrane protein [Function unknown]; Region: COG5427; cl02250 768490009962 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 768490009963 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 768490009964 Trp docking motif [polypeptide binding]; other site 768490009965 putative active site [active] 768490009966 galactoside permease; Reviewed; Region: lacY; PRK09528 768490009967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490009968 putative substrate translocation pore; other site 768490009969 alpha-galactosidase; Provisional; Region: PRK15076 768490009970 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 768490009971 NAD binding site [chemical binding]; other site 768490009972 sugar binding site [chemical binding]; other site 768490009973 divalent metal binding site [ion binding]; other site 768490009974 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 768490009975 dimer interface [polypeptide binding]; other site 768490009976 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768490009977 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768490009978 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490009979 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490009980 MATE family multidrug exporter; Provisional; Region: PRK10189 768490009981 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 768490009982 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 768490009983 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 768490009984 ligand binding site [chemical binding]; other site 768490009985 flexible hinge region; other site 768490009986 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 768490009987 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 768490009988 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 768490009989 ligand binding site [chemical binding]; other site 768490009990 flexible hinge region; other site 768490009991 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 768490009992 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 768490009993 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 768490009994 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 768490009995 putative NAD(P) binding site [chemical binding]; other site 768490009996 short chain dehydrogenase; Provisional; Region: PRK06179 768490009997 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 768490009998 NADP binding site [chemical binding]; other site 768490009999 active site 768490010000 steroid binding site; other site 768490010001 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 768490010002 classical (c) SDRs; Region: SDR_c; cd05233 768490010003 NAD(P) binding site [chemical binding]; other site 768490010004 active site 768490010005 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 768490010006 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 768490010007 FMN binding site [chemical binding]; other site 768490010008 active site 768490010009 substrate binding site [chemical binding]; other site 768490010010 catalytic residue [active] 768490010011 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768490010012 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768490010013 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768490010014 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768490010015 metal binding site [ion binding]; metal-binding site 768490010016 active site 768490010017 I-site; other site 768490010018 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 768490010019 active site 768490010020 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 768490010021 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 768490010022 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 768490010023 Uncharacterized conserved protein [Function unknown]; Region: COG5361 768490010024 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 768490010025 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 768490010026 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 768490010027 putative NAD(P) binding site [chemical binding]; other site 768490010028 catalytic Zn binding site [ion binding]; other site 768490010029 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 768490010030 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 768490010031 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768490010032 Walker A motif; other site 768490010033 ATP binding site [chemical binding]; other site 768490010034 Walker B motif; other site 768490010035 arginine finger; other site 768490010036 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 768490010037 DNA-binding interface [nucleotide binding]; DNA binding site 768490010038 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768490010039 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768490010040 DNA binding site [nucleotide binding] 768490010041 domain linker motif; other site 768490010042 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 768490010043 putative dimerization interface [polypeptide binding]; other site 768490010044 putative ligand binding site [chemical binding]; other site 768490010045 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 768490010046 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 768490010047 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 768490010048 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490010049 dimer interface [polypeptide binding]; other site 768490010050 conserved gate region; other site 768490010051 putative PBP binding loops; other site 768490010052 ABC-ATPase subunit interface; other site 768490010053 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490010054 dimer interface [polypeptide binding]; other site 768490010055 conserved gate region; other site 768490010056 putative PBP binding loops; other site 768490010057 ABC-ATPase subunit interface; other site 768490010058 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 768490010059 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768490010060 Walker A/P-loop; other site 768490010061 ATP binding site [chemical binding]; other site 768490010062 Q-loop/lid; other site 768490010063 ABC transporter signature motif; other site 768490010064 Walker B; other site 768490010065 D-loop; other site 768490010066 H-loop/switch region; other site 768490010067 TOBE domain; Region: TOBE_2; pfam08402 768490010068 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 768490010069 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 768490010070 active site 768490010071 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 768490010072 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 768490010073 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 768490010074 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 768490010075 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 768490010076 conserved cys residue [active] 768490010077 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490010078 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768490010079 short chain dehydrogenase; Provisional; Region: PRK06197 768490010080 NAD(P) binding site [chemical binding]; other site 768490010081 active site 768490010082 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 768490010083 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 768490010084 Putative transcription activator [Transcription]; Region: TenA; COG0819 768490010085 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 768490010086 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 768490010087 Walker A/P-loop; other site 768490010088 ATP binding site [chemical binding]; other site 768490010089 Q-loop/lid; other site 768490010090 ABC transporter signature motif; other site 768490010091 Walker B; other site 768490010092 D-loop; other site 768490010093 H-loop/switch region; other site 768490010094 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 768490010095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490010096 dimer interface [polypeptide binding]; other site 768490010097 conserved gate region; other site 768490010098 putative PBP binding loops; other site 768490010099 ABC-ATPase subunit interface; other site 768490010100 NMT1/THI5 like; Region: NMT1; pfam09084 768490010101 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 768490010102 substrate binding pocket [chemical binding]; other site 768490010103 membrane-bound complex binding site; other site 768490010104 hinge residues; other site 768490010105 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 768490010106 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768490010107 substrate binding pocket [chemical binding]; other site 768490010108 membrane-bound complex binding site; other site 768490010109 hinge residues; other site 768490010110 phosphoglycerol transferase I; Provisional; Region: PRK03776 768490010111 AMP nucleosidase; Provisional; Region: PRK08292 768490010112 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 768490010113 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 768490010114 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 768490010115 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490010116 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 768490010117 putative dimerization interface [polypeptide binding]; other site 768490010118 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 768490010119 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768490010120 NAD(P) binding site [chemical binding]; other site 768490010121 active site 768490010122 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768490010123 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768490010124 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490010125 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 768490010126 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 768490010127 TMP-binding site; other site 768490010128 ATP-binding site [chemical binding]; other site 768490010129 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490010130 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490010131 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 768490010132 putative effector binding pocket; other site 768490010133 putative dimerization interface [polypeptide binding]; other site 768490010134 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768490010135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490010136 putative substrate translocation pore; other site 768490010137 Predicted transcriptional regulators [Transcription]; Region: COG1733 768490010138 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 768490010139 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 768490010140 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 768490010141 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768490010142 putative NAD(P) binding site [chemical binding]; other site 768490010143 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 768490010144 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 768490010145 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 768490010146 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 768490010147 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768490010148 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768490010149 catalytic residue [active] 768490010150 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 768490010151 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 768490010152 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 768490010153 active site residue [active] 768490010154 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 768490010155 active site residue [active] 768490010156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490010157 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768490010158 putative substrate translocation pore; other site 768490010159 Serine hydrolase; Region: Ser_hydrolase; pfam06821 768490010160 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768490010161 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768490010162 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768490010163 putative DNA binding site [nucleotide binding]; other site 768490010164 putative Zn2+ binding site [ion binding]; other site 768490010165 AsnC family; Region: AsnC_trans_reg; pfam01037 768490010166 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 768490010167 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 768490010168 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 768490010169 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 768490010170 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 768490010171 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 768490010172 methionine synthase; Provisional; Region: PRK01207 768490010173 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 768490010174 substrate binding site [chemical binding]; other site 768490010175 THF binding site; other site 768490010176 zinc-binding site [ion binding]; other site 768490010177 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 768490010178 substrate binding site [chemical binding]; other site 768490010179 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768490010180 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490010181 citrate-proton symporter; Provisional; Region: PRK15075 768490010182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490010183 putative substrate translocation pore; other site 768490010184 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 768490010185 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 768490010186 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490010187 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490010188 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 768490010189 putative dimerization interface [polypeptide binding]; other site 768490010190 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 768490010191 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 768490010192 intersubunit interface [polypeptide binding]; other site 768490010193 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490010194 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490010195 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 768490010196 putative effector binding pocket; other site 768490010197 putative dimerization interface [polypeptide binding]; other site 768490010198 Restriction endonuclease; Region: Mrr_cat; pfam04471 768490010199 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 768490010200 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768490010201 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768490010202 putative active site [active] 768490010203 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 768490010204 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768490010205 N-terminal plug; other site 768490010206 ligand-binding site [chemical binding]; other site 768490010207 galactoside permease; Reviewed; Region: lacY; PRK09528 768490010208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490010209 putative substrate translocation pore; other site 768490010210 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 768490010211 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 768490010212 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 768490010213 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 768490010214 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 768490010215 lac repressor; Reviewed; Region: lacI; PRK09526 768490010216 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768490010217 DNA binding site [nucleotide binding] 768490010218 domain linker motif; other site 768490010219 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 768490010220 ligand binding site [chemical binding]; other site 768490010221 dimerization interface (open form) [polypeptide binding]; other site 768490010222 dimerization interface (closed form) [polypeptide binding]; other site 768490010223 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768490010224 HAMP domain; Region: HAMP; pfam00672 768490010225 dimerization interface [polypeptide binding]; other site 768490010226 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768490010227 dimer interface [polypeptide binding]; other site 768490010228 phosphorylation site [posttranslational modification] 768490010229 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490010230 ATP binding site [chemical binding]; other site 768490010231 Mg2+ binding site [ion binding]; other site 768490010232 G-X-G motif; other site 768490010233 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768490010234 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768490010235 DNA binding residues [nucleotide binding] 768490010236 dimerization interface [polypeptide binding]; other site 768490010237 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768490010238 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490010239 active site 768490010240 phosphorylation site [posttranslational modification] 768490010241 intermolecular recognition site; other site 768490010242 dimerization interface [polypeptide binding]; other site 768490010243 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768490010244 DNA binding site [nucleotide binding] 768490010245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 768490010246 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 768490010247 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490010248 Coenzyme A binding pocket [chemical binding]; other site 768490010249 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768490010250 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768490010251 sequence-specific DNA binding site [nucleotide binding]; other site 768490010252 salt bridge; other site 768490010253 Cupin domain; Region: Cupin_2; pfam07883 768490010254 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 768490010255 putative FMN binding site [chemical binding]; other site 768490010256 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768490010257 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490010258 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768490010259 dimerization interface [polypeptide binding]; other site 768490010260 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 768490010261 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768490010262 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 768490010263 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 768490010264 putative active site [active] 768490010265 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 768490010266 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 768490010267 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 768490010268 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 768490010269 active site 768490010270 dimer interface [polypeptide binding]; other site 768490010271 non-prolyl cis peptide bond; other site 768490010272 insertion regions; other site 768490010273 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 768490010274 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768490010275 Walker A motif; other site 768490010276 ATP binding site [chemical binding]; other site 768490010277 Walker B motif; other site 768490010278 arginine finger; other site 768490010279 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 768490010280 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 768490010281 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768490010282 substrate binding pocket [chemical binding]; other site 768490010283 membrane-bound complex binding site; other site 768490010284 hinge residues; other site 768490010285 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 768490010286 alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030 768490010287 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 768490010288 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 768490010289 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 768490010290 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 768490010291 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768490010292 Walker A/P-loop; other site 768490010293 ATP binding site [chemical binding]; other site 768490010294 Q-loop/lid; other site 768490010295 ABC transporter signature motif; other site 768490010296 Walker B; other site 768490010297 D-loop; other site 768490010298 H-loop/switch region; other site 768490010299 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768490010300 Walker A/P-loop; other site 768490010301 ATP binding site [chemical binding]; other site 768490010302 Q-loop/lid; other site 768490010303 ABC transporter signature motif; other site 768490010304 Walker B; other site 768490010305 D-loop; other site 768490010306 H-loop/switch region; other site 768490010307 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 768490010308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490010309 putative PBP binding loops; other site 768490010310 ABC-ATPase subunit interface; other site 768490010311 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 768490010312 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 768490010313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490010314 dimer interface [polypeptide binding]; other site 768490010315 conserved gate region; other site 768490010316 putative PBP binding loops; other site 768490010317 ABC-ATPase subunit interface; other site 768490010318 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 768490010319 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 768490010320 alanine-tRNA ligase; Region: PLN02961 768490010321 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 768490010322 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490010323 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490010324 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768490010325 putative effector binding pocket; other site 768490010326 dimerization interface [polypeptide binding]; other site 768490010327 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 768490010328 Predicted permeases [General function prediction only]; Region: RarD; COG2962 768490010329 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 768490010330 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 768490010331 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 768490010332 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 768490010333 catalytic core [active] 768490010334 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 768490010335 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 768490010336 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 768490010337 transmembrane helices; other site 768490010338 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 768490010339 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 768490010340 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 768490010341 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 768490010342 citrate lyase subunit gamma; Provisional; Region: PRK13253 768490010343 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 768490010344 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 768490010345 putative active site [active] 768490010346 (T/H)XGH motif; other site 768490010347 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 768490010348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490010349 active site 768490010350 phosphorylation site [posttranslational modification] 768490010351 intermolecular recognition site; other site 768490010352 dimerization interface [polypeptide binding]; other site 768490010353 Transcriptional regulator; Region: CitT; pfam12431 768490010354 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 768490010355 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 768490010356 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824 768490010357 putative hydrophobic ligand binding site [chemical binding]; other site 768490010358 acetoin reductases; Region: 23BDH; TIGR02415 768490010359 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768490010360 NAD(P) binding site [chemical binding]; other site 768490010361 active site 768490010362 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 768490010363 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 768490010364 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768490010365 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768490010366 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768490010367 E3 interaction surface; other site 768490010368 lipoyl attachment site [posttranslational modification]; other site 768490010369 dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843 768490010370 e3 binding domain; Region: E3_binding; pfam02817 768490010371 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 768490010372 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 768490010373 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 768490010374 alpha subunit interface [polypeptide binding]; other site 768490010375 TPP binding site [chemical binding]; other site 768490010376 heterodimer interface [polypeptide binding]; other site 768490010377 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768490010378 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 768490010379 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 768490010380 tetramer interface [polypeptide binding]; other site 768490010381 TPP-binding site [chemical binding]; other site 768490010382 heterodimer interface [polypeptide binding]; other site 768490010383 phosphorylation loop region [posttranslational modification] 768490010384 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 768490010385 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 768490010386 Walker A motif; other site 768490010387 ATP binding site [chemical binding]; other site 768490010388 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768490010389 DNA binding residues [nucleotide binding] 768490010390 dimerization interface [polypeptide binding]; other site 768490010391 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 768490010392 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 768490010393 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 768490010394 dimer interface [polypeptide binding]; other site 768490010395 active site 768490010396 heme binding site [chemical binding]; other site 768490010397 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 768490010398 HipA N-terminal domain; Region: Couple_hipA; pfam13657 768490010399 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 768490010400 HipA-like N-terminal domain; Region: HipA_N; pfam07805 768490010401 HipA-like C-terminal domain; Region: HipA_C; pfam07804 768490010402 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768490010403 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768490010404 non-specific DNA binding site [nucleotide binding]; other site 768490010405 salt bridge; other site 768490010406 sequence-specific DNA binding site [nucleotide binding]; other site 768490010407 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 768490010408 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768490010409 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490010410 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 768490010411 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490010412 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490010413 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 768490010414 putative effector binding pocket; other site 768490010415 putative dimerization interface [polypeptide binding]; other site 768490010416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490010417 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768490010418 putative substrate translocation pore; other site 768490010419 putative arabinose transporter; Provisional; Region: PRK03545 768490010420 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490010421 putative substrate translocation pore; other site 768490010422 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 768490010423 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 768490010424 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 768490010425 Walker A/P-loop; other site 768490010426 ATP binding site [chemical binding]; other site 768490010427 Q-loop/lid; other site 768490010428 ABC transporter signature motif; other site 768490010429 Walker B; other site 768490010430 D-loop; other site 768490010431 H-loop/switch region; other site 768490010432 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 768490010433 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 768490010434 Walker A/P-loop; other site 768490010435 ATP binding site [chemical binding]; other site 768490010436 Q-loop/lid; other site 768490010437 ABC transporter signature motif; other site 768490010438 Walker B; other site 768490010439 D-loop; other site 768490010440 H-loop/switch region; other site 768490010441 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 768490010442 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 768490010443 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 768490010444 TM-ABC transporter signature motif; other site 768490010445 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768490010446 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 768490010447 TM-ABC transporter signature motif; other site 768490010448 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 768490010449 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 768490010450 dimerization interface [polypeptide binding]; other site 768490010451 ligand binding site [chemical binding]; other site 768490010452 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490010453 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490010454 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 768490010455 putative effector binding pocket; other site 768490010456 putative dimerization interface [polypeptide binding]; other site 768490010457 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 768490010458 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768490010459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490010460 putative substrate translocation pore; other site 768490010461 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490010462 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490010463 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768490010464 putative effector binding pocket; other site 768490010465 dimerization interface [polypeptide binding]; other site 768490010466 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 768490010467 active sites [active] 768490010468 tetramer interface [polypeptide binding]; other site 768490010469 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 768490010470 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 768490010471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490010472 dimer interface [polypeptide binding]; other site 768490010473 conserved gate region; other site 768490010474 ABC-ATPase subunit interface; other site 768490010475 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 768490010476 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768490010477 Walker A/P-loop; other site 768490010478 ATP binding site [chemical binding]; other site 768490010479 Q-loop/lid; other site 768490010480 ABC transporter signature motif; other site 768490010481 Walker B; other site 768490010482 D-loop; other site 768490010483 H-loop/switch region; other site 768490010484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490010485 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768490010486 putative substrate translocation pore; other site 768490010487 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 768490010488 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 768490010489 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768490010490 HlyD family secretion protein; Region: HlyD_3; pfam13437 768490010491 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768490010492 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768490010493 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 768490010494 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 768490010495 Predicted transcriptional regulators [Transcription]; Region: COG1733 768490010496 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 768490010497 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 768490010498 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 768490010499 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 768490010500 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490010501 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768490010502 dimerization interface [polypeptide binding]; other site 768490010503 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 768490010504 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 768490010505 metal binding site [ion binding]; metal-binding site 768490010506 putative dimer interface [polypeptide binding]; other site 768490010507 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 768490010508 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768490010509 substrate binding pocket [chemical binding]; other site 768490010510 membrane-bound complex binding site; other site 768490010511 hinge residues; other site 768490010512 hypothetical protein; Provisional; Region: PRK05423 768490010513 Predicted membrane protein [Function unknown]; Region: COG1289 768490010514 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 768490010515 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 768490010516 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 768490010517 amidase catalytic site [active] 768490010518 Zn binding residues [ion binding]; other site 768490010519 substrate binding site [chemical binding]; other site 768490010520 Predicted transcriptional regulator [Transcription]; Region: COG2932 768490010521 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 768490010522 Catalytic site [active] 768490010523 Male sterility protein; Region: NAD_binding_4; pfam07993 768490010524 NAD(P) binding site [chemical binding]; other site 768490010525 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 768490010526 active site 768490010527 DNA polymerase III, theta subunit; Region: DNA_pol3_theta; cl11635 768490010528 exonuclease I; Provisional; Region: sbcB; PRK11779 768490010529 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 768490010530 active site 768490010531 catalytic site [active] 768490010532 substrate binding site [chemical binding]; other site 768490010533 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 768490010534 amino acid transporter; Region: 2A0306; TIGR00909 768490010535 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 768490010536 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 768490010537 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 768490010538 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768490010539 non-specific DNA binding site [nucleotide binding]; other site 768490010540 salt bridge; other site 768490010541 sequence-specific DNA binding site [nucleotide binding]; other site 768490010542 Cupin domain; Region: Cupin_2; pfam07883 768490010543 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 768490010544 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 768490010545 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 768490010546 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768490010547 Walker A/P-loop; other site 768490010548 ATP binding site [chemical binding]; other site 768490010549 Q-loop/lid; other site 768490010550 ABC transporter signature motif; other site 768490010551 Walker B; other site 768490010552 D-loop; other site 768490010553 H-loop/switch region; other site 768490010554 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768490010555 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768490010556 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768490010557 TM-ABC transporter signature motif; other site 768490010558 putative outer membrane receptor; Provisional; Region: PRK13513 768490010559 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768490010560 N-terminal plug; other site 768490010561 ligand-binding site [chemical binding]; other site 768490010562 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 768490010563 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768490010564 Walker A/P-loop; other site 768490010565 ATP binding site [chemical binding]; other site 768490010566 Q-loop/lid; other site 768490010567 ABC transporter signature motif; other site 768490010568 Walker B; other site 768490010569 D-loop; other site 768490010570 H-loop/switch region; other site 768490010571 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 768490010572 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 768490010573 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768490010574 ABC-ATPase subunit interface; other site 768490010575 dimer interface [polypeptide binding]; other site 768490010576 putative PBP binding regions; other site 768490010577 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768490010578 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768490010579 metal binding site [ion binding]; metal-binding site 768490010580 active site 768490010581 I-site; other site 768490010582 lysine transporter; Provisional; Region: PRK10836 768490010583 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 768490010584 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490010585 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 768490010586 putative dimerization interface [polypeptide binding]; other site 768490010587 Predicted membrane protein [Function unknown]; Region: COG2855 768490010588 endonuclease IV; Provisional; Region: PRK01060 768490010589 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 768490010590 AP (apurinic/apyrimidinic) site pocket; other site 768490010591 DNA interaction; other site 768490010592 Metal-binding active site; metal-binding site 768490010593 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 768490010594 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 768490010595 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 768490010596 active site 768490010597 P-loop; other site 768490010598 phosphorylation site [posttranslational modification] 768490010599 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 768490010600 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 768490010601 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 768490010602 putative substrate binding site [chemical binding]; other site 768490010603 putative ATP binding site [chemical binding]; other site 768490010604 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 768490010605 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 768490010606 active site 768490010607 phosphorylation site [posttranslational modification] 768490010608 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 768490010609 dimerization domain swap beta strand [polypeptide binding]; other site 768490010610 regulatory protein interface [polypeptide binding]; other site 768490010611 active site 768490010612 regulatory phosphorylation site [posttranslational modification]; other site 768490010613 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_19; cd04678 768490010614 nudix motif; other site 768490010615 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 768490010616 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 768490010617 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 768490010618 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 768490010619 molybdopterin cofactor binding site [chemical binding]; other site 768490010620 substrate binding site [chemical binding]; other site 768490010621 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 768490010622 molybdopterin cofactor binding site; other site 768490010623 sugar efflux transporter B; Provisional; Region: PRK15011 768490010624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490010625 putative substrate translocation pore; other site 768490010626 Flagellin N-methylase; Region: FliB; cl00497 768490010627 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 768490010628 aromatic amino acid transport protein; Region: araaP; TIGR00837 768490010629 elongation factor P; Provisional; Region: PRK04542 768490010630 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 768490010631 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 768490010632 RNA binding site [nucleotide binding]; other site 768490010633 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 768490010634 RNA binding site [nucleotide binding]; other site 768490010635 mannonate dehydratase; Provisional; Region: PRK03906 768490010636 mannonate dehydratase; Region: uxuA; TIGR00695 768490010637 D-mannonate oxidoreductase; Provisional; Region: PRK15037 768490010638 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 768490010639 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 768490010640 Fimbrial protein; Region: Fimbrial; cl01416 768490010641 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 768490010642 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 768490010643 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 768490010644 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 768490010645 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 768490010646 active site 768490010647 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 768490010648 NlpC/P60 family; Region: NLPC_P60; pfam00877 768490010649 phage resistance protein; Provisional; Region: PRK10551 768490010650 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 768490010651 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768490010652 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 768490010653 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 768490010654 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 768490010655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490010656 dimer interface [polypeptide binding]; other site 768490010657 conserved gate region; other site 768490010658 putative PBP binding loops; other site 768490010659 ABC-ATPase subunit interface; other site 768490010660 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 768490010661 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 768490010662 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490010663 dimer interface [polypeptide binding]; other site 768490010664 conserved gate region; other site 768490010665 putative PBP binding loops; other site 768490010666 ABC-ATPase subunit interface; other site 768490010667 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 768490010668 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768490010669 Walker A/P-loop; other site 768490010670 ATP binding site [chemical binding]; other site 768490010671 Q-loop/lid; other site 768490010672 ABC transporter signature motif; other site 768490010673 Walker B; other site 768490010674 D-loop; other site 768490010675 H-loop/switch region; other site 768490010676 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768490010677 Walker A/P-loop; other site 768490010678 ATP binding site [chemical binding]; other site 768490010679 Q-loop/lid; other site 768490010680 ABC transporter signature motif; other site 768490010681 Walker B; other site 768490010682 D-loop; other site 768490010683 H-loop/switch region; other site 768490010684 hypothetical protein; Provisional; Region: PRK11835 768490010685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490010686 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 768490010687 putative substrate translocation pore; other site 768490010688 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 768490010689 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768490010690 RNA binding surface [nucleotide binding]; other site 768490010691 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 768490010692 active site 768490010693 uracil binding [chemical binding]; other site 768490010694 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 768490010695 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768490010696 ATP binding site [chemical binding]; other site 768490010697 putative Mg++ binding site [ion binding]; other site 768490010698 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768490010699 nucleotide binding region [chemical binding]; other site 768490010700 ATP-binding site [chemical binding]; other site 768490010701 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 768490010702 5S rRNA interface [nucleotide binding]; other site 768490010703 CTC domain interface [polypeptide binding]; other site 768490010704 L16 interface [polypeptide binding]; other site 768490010705 Nucleoid-associated protein [General function prediction only]; Region: COG3081 768490010706 nucleoid-associated protein NdpA; Validated; Region: PRK00378 768490010707 hypothetical protein; Provisional; Region: PRK13689 768490010708 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 768490010709 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 768490010710 Sulfatase; Region: Sulfatase; cl17466 768490010711 DinI-like family; Region: DinI; cl11630 768490010712 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 768490010713 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 768490010714 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 768490010715 active site 768490010716 oxyanion hole [active] 768490010717 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 768490010718 Phage-related protein, tail component [Function unknown]; Region: COG4733 768490010719 Putative phage tail protein; Region: Phage-tail_3; pfam13550 768490010720 Fibronectin type 3 domain; Region: FN3; smart00060 768490010721 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 768490010722 Fibronectin type III protein; Region: DUF3672; pfam12421 768490010723 Phage-related protein, tail component [Function unknown]; Region: COG4723 768490010724 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 768490010725 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 768490010726 MPN+ (JAMM) motif; other site 768490010727 Zinc-binding site [ion binding]; other site 768490010728 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 768490010729 NlpC/P60 family; Region: NLPC_P60; cl17555 768490010730 Phage-related protein [Function unknown]; Region: gp18; COG4672 768490010731 Phage minor tail protein; Region: Phage_min_tail; pfam05939 768490010732 Phage-related minor tail protein [Function unknown]; Region: COG5281 768490010733 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 768490010734 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 768490010735 Minor tail protein T; Region: Phage_tail_T; cl05636 768490010736 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; cl06106 768490010737 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 768490010738 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 768490010739 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 768490010740 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 768490010741 Uncharacterized conserved protein (DUF2190); Region: DUF2190; cl02289 768490010742 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 768490010743 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 768490010744 oligomer interface [polypeptide binding]; other site 768490010745 active site residues [active] 768490010746 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 768490010747 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 768490010748 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 768490010749 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 768490010750 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 768490010751 Protein of unknown function (DUF2560); Region: DUF2560; cl10280 768490010752 DNA polymerase III, theta subunit; Region: DNA_pol3_theta; pfam06440 768490010753 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 768490010754 Protein of unknown function (DUF754); Region: DUF754; pfam05449 768490010755 Antitermination protein; Region: Antiterm; pfam03589 768490010756 Antitermination protein; Region: Antiterm; pfam03589 768490010757 Protein of unknown function (DUF968); Region: DUF968; pfam06147 768490010758 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 768490010759 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 768490010760 cofactor binding site; other site 768490010761 DNA binding site [nucleotide binding] 768490010762 substrate interaction site [chemical binding]; other site 768490010763 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 768490010764 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 768490010765 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 768490010766 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 768490010767 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 768490010768 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 768490010769 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768490010770 non-specific DNA binding site [nucleotide binding]; other site 768490010771 salt bridge; other site 768490010772 sequence-specific DNA binding site [nucleotide binding]; other site 768490010773 tellurite resistance protein terB; Region: terB; cd07176 768490010774 putative metal binding site [ion binding]; other site 768490010775 Uncharacterized conserved protein (DUF2303); Region: DUF2303; pfam10065 768490010776 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 768490010777 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 768490010778 DNA-binding interface [nucleotide binding]; DNA binding site 768490010779 Protein of unknown function (DUF551); Region: DUF551; pfam04448 768490010780 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 768490010781 active site 768490010782 catalytic site [active] 768490010783 substrate binding site [chemical binding]; other site 768490010784 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 768490010785 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768490010786 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768490010787 active site 768490010788 DNA binding site [nucleotide binding] 768490010789 Int/Topo IB signature motif; other site 768490010790 Acyltransferase family; Region: Acyl_transf_3; pfam01757 768490010791 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 768490010792 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 768490010793 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 768490010794 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 768490010795 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 768490010796 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 768490010797 SnoaL-like domain; Region: SnoaL_2; pfam12680 768490010798 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768490010799 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768490010800 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768490010801 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 768490010802 putative metal binding site [ion binding]; other site 768490010803 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 768490010804 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 768490010805 trimer interface [polypeptide binding]; other site 768490010806 eyelet of channel; other site 768490010807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490010808 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768490010809 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 768490010810 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490010811 ATP binding site [chemical binding]; other site 768490010812 Mg2+ binding site [ion binding]; other site 768490010813 G-X-G motif; other site 768490010814 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 768490010815 putative binding surface; other site 768490010816 active site 768490010817 transcriptional regulator RcsB; Provisional; Region: PRK10840 768490010818 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490010819 active site 768490010820 phosphorylation site [posttranslational modification] 768490010821 intermolecular recognition site; other site 768490010822 dimerization interface [polypeptide binding]; other site 768490010823 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768490010824 DNA binding residues [nucleotide binding] 768490010825 dimerization interface [polypeptide binding]; other site 768490010826 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 768490010827 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768490010828 dimer interface [polypeptide binding]; other site 768490010829 phosphorylation site [posttranslational modification] 768490010830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490010831 ATP binding site [chemical binding]; other site 768490010832 Mg2+ binding site [ion binding]; other site 768490010833 G-X-G motif; other site 768490010834 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 768490010835 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490010836 active site 768490010837 phosphorylation site [posttranslational modification] 768490010838 intermolecular recognition site; other site 768490010839 dimerization interface [polypeptide binding]; other site 768490010840 DNA gyrase subunit A; Validated; Region: PRK05560 768490010841 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 768490010842 CAP-like domain; other site 768490010843 active site 768490010844 primary dimer interface [polypeptide binding]; other site 768490010845 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768490010846 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768490010847 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768490010848 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768490010849 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768490010850 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768490010851 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 768490010852 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490010853 S-adenosylmethionine binding site [chemical binding]; other site 768490010854 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 768490010855 ATP cone domain; Region: ATP-cone; pfam03477 768490010856 Class I ribonucleotide reductase; Region: RNR_I; cd01679 768490010857 active site 768490010858 dimer interface [polypeptide binding]; other site 768490010859 catalytic residues [active] 768490010860 effector binding site; other site 768490010861 R2 peptide binding site; other site 768490010862 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 768490010863 dimer interface [polypeptide binding]; other site 768490010864 putative radical transfer pathway; other site 768490010865 diiron center [ion binding]; other site 768490010866 tyrosyl radical; other site 768490010867 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768490010868 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 768490010869 catalytic loop [active] 768490010870 iron binding site [ion binding]; other site 768490010871 Hok/gef family; Region: HOK_GEF; cl11494 768490010872 hypothetical protein; Provisional; Region: PRK03673 768490010873 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 768490010874 putative MPT binding site; other site 768490010875 tyrosine transporter TyrP; Provisional; Region: PRK15132 768490010876 aromatic amino acid transport protein; Region: araaP; TIGR00837 768490010877 YfaZ precursor; Region: YfaZ; pfam07437 768490010878 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 768490010879 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 768490010880 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 768490010881 tetramer interface [polypeptide binding]; other site 768490010882 heme binding pocket [chemical binding]; other site 768490010883 NADPH binding site [chemical binding]; other site 768490010884 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 768490010885 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 768490010886 acyl-activating enzyme (AAE) consensus motif; other site 768490010887 putative AMP binding site [chemical binding]; other site 768490010888 putative active site [active] 768490010889 putative CoA binding site [chemical binding]; other site 768490010890 O-succinylbenzoate synthase; Provisional; Region: PRK05105 768490010891 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 768490010892 active site 768490010893 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768490010894 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 768490010895 substrate binding site [chemical binding]; other site 768490010896 oxyanion hole (OAH) forming residues; other site 768490010897 trimer interface [polypeptide binding]; other site 768490010898 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 768490010899 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 768490010900 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 768490010901 dimer interface [polypeptide binding]; other site 768490010902 tetramer interface [polypeptide binding]; other site 768490010903 PYR/PP interface [polypeptide binding]; other site 768490010904 TPP binding site [chemical binding]; other site 768490010905 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 768490010906 TPP-binding site; other site 768490010907 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 768490010908 chorismate binding enzyme; Region: Chorismate_bind; cl10555 768490010909 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 768490010910 Putative glucoamylase; Region: Glycoamylase; pfam10091 768490010911 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 768490010912 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 768490010913 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 768490010914 hypothetical protein; Provisional; Region: PRK10404 768490010915 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 768490010916 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 768490010917 putative NAD(P) binding site [chemical binding]; other site 768490010918 catalytic Zn binding site [ion binding]; other site 768490010919 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 768490010920 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 768490010921 NADP binding site [chemical binding]; other site 768490010922 homodimer interface [polypeptide binding]; other site 768490010923 active site 768490010924 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 768490010925 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768490010926 DNA binding site [nucleotide binding] 768490010927 domain linker motif; other site 768490010928 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 768490010929 putative ligand binding site [chemical binding]; other site 768490010930 putative dimerization interface [polypeptide binding]; other site 768490010931 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 768490010932 Transmembrane secretion effector; Region: MFS_3; pfam05977 768490010933 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 768490010934 Cupin domain; Region: Cupin_2; cl17218 768490010935 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 768490010936 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768490010937 PYR/PP interface [polypeptide binding]; other site 768490010938 dimer interface [polypeptide binding]; other site 768490010939 TPP binding site [chemical binding]; other site 768490010940 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768490010941 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 768490010942 TPP-binding site [chemical binding]; other site 768490010943 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490010944 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490010945 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768490010946 dimerization interface [polypeptide binding]; other site 768490010947 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 768490010948 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 768490010949 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 768490010950 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 768490010951 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 768490010952 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 768490010953 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 768490010954 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 768490010955 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 768490010956 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 768490010957 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 768490010958 4Fe-4S binding domain; Region: Fer4; pfam00037 768490010959 4Fe-4S binding domain; Region: Fer4; pfam00037 768490010960 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 768490010961 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 768490010962 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768490010963 catalytic loop [active] 768490010964 iron binding site [ion binding]; other site 768490010965 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 768490010966 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 768490010967 [4Fe-4S] binding site [ion binding]; other site 768490010968 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 768490010969 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 768490010970 SLBB domain; Region: SLBB; pfam10531 768490010971 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 768490010972 NADH dehydrogenase subunit E; Validated; Region: PRK07539 768490010973 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 768490010974 putative dimer interface [polypeptide binding]; other site 768490010975 [2Fe-2S] cluster binding site [ion binding]; other site 768490010976 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 768490010977 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 768490010978 NADH dehydrogenase subunit D; Validated; Region: PRK06075 768490010979 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 768490010980 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 768490010981 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 768490010982 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490010983 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 768490010984 putative dimerization interface [polypeptide binding]; other site 768490010985 aminotransferase AlaT; Validated; Region: PRK09265 768490010986 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768490010987 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490010988 homodimer interface [polypeptide binding]; other site 768490010989 catalytic residue [active] 768490010990 5'-nucleotidase; Provisional; Region: PRK03826 768490010991 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 768490010992 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 768490010993 TrkA-C domain; Region: TrkA_C; pfam02080 768490010994 TrkA-C domain; Region: TrkA_C; pfam02080 768490010995 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 768490010996 putative phosphatase; Provisional; Region: PRK11587 768490010997 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768490010998 motif II; other site 768490010999 hypothetical protein; Validated; Region: PRK05445 768490011000 hypothetical protein; Provisional; Region: PRK01816 768490011001 propionate/acetate kinase; Provisional; Region: PRK12379 768490011002 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 768490011003 phosphate acetyltransferase; Reviewed; Region: PRK05632 768490011004 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 768490011005 DRTGG domain; Region: DRTGG; pfam07085 768490011006 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 768490011007 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 768490011008 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 768490011009 nudix motif; other site 768490011010 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 768490011011 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 768490011012 active site 768490011013 metal binding site [ion binding]; metal-binding site 768490011014 homotetramer interface [polypeptide binding]; other site 768490011015 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 768490011016 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 768490011017 C-terminal domain interface [polypeptide binding]; other site 768490011018 GSH binding site (G-site) [chemical binding]; other site 768490011019 dimer interface [polypeptide binding]; other site 768490011020 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 768490011021 N-terminal domain interface [polypeptide binding]; other site 768490011022 putative dimer interface [polypeptide binding]; other site 768490011023 active site 768490011024 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 768490011025 homooctamer interface [polypeptide binding]; other site 768490011026 active site 768490011027 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 768490011028 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 768490011029 putative NAD(P) binding site [chemical binding]; other site 768490011030 putative active site [active] 768490011031 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 768490011032 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 768490011033 Walker A/P-loop; other site 768490011034 ATP binding site [chemical binding]; other site 768490011035 Q-loop/lid; other site 768490011036 ABC transporter signature motif; other site 768490011037 Walker B; other site 768490011038 D-loop; other site 768490011039 H-loop/switch region; other site 768490011040 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768490011041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490011042 dimer interface [polypeptide binding]; other site 768490011043 conserved gate region; other site 768490011044 putative PBP binding loops; other site 768490011045 ABC-ATPase subunit interface; other site 768490011046 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768490011047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490011048 dimer interface [polypeptide binding]; other site 768490011049 conserved gate region; other site 768490011050 putative PBP binding loops; other site 768490011051 ABC-ATPase subunit interface; other site 768490011052 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768490011053 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768490011054 substrate binding pocket [chemical binding]; other site 768490011055 membrane-bound complex binding site; other site 768490011056 hinge residues; other site 768490011057 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 768490011058 Flavoprotein; Region: Flavoprotein; pfam02441 768490011059 amidophosphoribosyltransferase; Provisional; Region: PRK09246 768490011060 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 768490011061 active site 768490011062 tetramer interface [polypeptide binding]; other site 768490011063 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768490011064 active site 768490011065 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 768490011066 colicin V production protein; Provisional; Region: PRK10845 768490011067 cell division protein DedD; Provisional; Region: PRK11633 768490011068 Sporulation related domain; Region: SPOR; pfam05036 768490011069 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 768490011070 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768490011071 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768490011072 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 768490011073 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 768490011074 hypothetical protein; Provisional; Region: PRK10847 768490011075 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 768490011076 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 768490011077 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 768490011078 dimerization interface 3.5A [polypeptide binding]; other site 768490011079 active site 768490011080 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 768490011081 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 768490011082 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 768490011083 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 768490011084 ligand binding site [chemical binding]; other site 768490011085 NAD binding site [chemical binding]; other site 768490011086 catalytic site [active] 768490011087 homodimer interface [polypeptide binding]; other site 768490011088 Cupin domain; Region: Cupin_2; cl17218 768490011089 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768490011090 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490011091 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490011092 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768490011093 EamA-like transporter family; Region: EamA; pfam00892 768490011094 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 768490011095 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768490011096 HAMP domain; Region: HAMP; pfam00672 768490011097 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768490011098 dimer interface [polypeptide binding]; other site 768490011099 phosphorylation site [posttranslational modification] 768490011100 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490011101 ATP binding site [chemical binding]; other site 768490011102 Mg2+ binding site [ion binding]; other site 768490011103 G-X-G motif; other site 768490011104 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 768490011105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490011106 active site 768490011107 phosphorylation site [posttranslational modification] 768490011108 intermolecular recognition site; other site 768490011109 dimerization interface [polypeptide binding]; other site 768490011110 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768490011111 DNA binding site [nucleotide binding] 768490011112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 768490011113 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 768490011114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 768490011115 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 768490011116 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 768490011117 trimer interface [polypeptide binding]; other site 768490011118 active site 768490011119 CoA binding site [chemical binding]; other site 768490011120 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 768490011121 EamA-like transporter family; Region: EamA; pfam00892 768490011122 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768490011123 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768490011124 DNA-binding site [nucleotide binding]; DNA binding site 768490011125 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768490011126 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490011127 homodimer interface [polypeptide binding]; other site 768490011128 catalytic residue [active] 768490011129 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 768490011130 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 768490011131 catalytic residues [active] 768490011132 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 768490011133 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 768490011134 catalytic residues [active] 768490011135 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 768490011136 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 768490011137 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 768490011138 DsbD alpha interface [polypeptide binding]; other site 768490011139 catalytic residues [active] 768490011140 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 768490011141 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 768490011142 active site residue [active] 768490011143 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768490011144 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768490011145 DNA-binding site [nucleotide binding]; DNA binding site 768490011146 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768490011147 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490011148 homodimer interface [polypeptide binding]; other site 768490011149 catalytic residue [active] 768490011150 putative transporter; Provisional; Region: PRK12382 768490011151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490011152 putative substrate translocation pore; other site 768490011153 putative catalytic site [active] 768490011154 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 768490011155 putative metal binding site [ion binding]; other site 768490011156 putative phosphate binding site [ion binding]; other site 768490011157 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 768490011158 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 768490011159 metal binding site [ion binding]; metal-binding site 768490011160 dimer interface [polypeptide binding]; other site 768490011161 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 768490011162 transmembrane helices; other site 768490011163 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 768490011164 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 768490011165 ApbE family; Region: ApbE; pfam02424 768490011166 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 768490011167 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 768490011168 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 768490011169 dimer interface [polypeptide binding]; other site 768490011170 active site 768490011171 Uncharacterized conserved protein [Function unknown]; Region: COG4121 768490011172 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 768490011173 YfcL protein; Region: YfcL; pfam08891 768490011174 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 768490011175 hypothetical protein; Provisional; Region: PRK10621 768490011176 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 768490011177 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 768490011178 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 768490011179 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 768490011180 Tetramer interface [polypeptide binding]; other site 768490011181 active site 768490011182 FMN-binding site [chemical binding]; other site 768490011183 HemK family putative methylases; Region: hemK_fam; TIGR00536 768490011184 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490011185 S-adenosylmethionine binding site [chemical binding]; other site 768490011186 hypothetical protein; Provisional; Region: PRK04946 768490011187 Smr domain; Region: Smr; pfam01713 768490011188 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768490011189 catalytic core [active] 768490011190 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 768490011191 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768490011192 substrate binding site [chemical binding]; other site 768490011193 oxyanion hole (OAH) forming residues; other site 768490011194 trimer interface [polypeptide binding]; other site 768490011195 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 768490011196 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768490011197 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768490011198 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 768490011199 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 768490011200 dimer interface [polypeptide binding]; other site 768490011201 active site 768490011202 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 768490011203 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 768490011204 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 768490011205 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 768490011206 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 768490011207 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768490011208 binding surface 768490011209 TPR motif; other site 768490011210 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 768490011211 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 768490011212 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 768490011213 catalytic residues [active] 768490011214 central insert; other site 768490011215 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 768490011216 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 768490011217 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 768490011218 heme exporter protein CcmC; Region: ccmC; TIGR01191 768490011219 heme exporter protein CcmB; Region: ccmB; TIGR01190 768490011220 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 768490011221 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 768490011222 Walker A/P-loop; other site 768490011223 ATP binding site [chemical binding]; other site 768490011224 Q-loop/lid; other site 768490011225 ABC transporter signature motif; other site 768490011226 Walker B; other site 768490011227 D-loop; other site 768490011228 H-loop/switch region; other site 768490011229 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 768490011230 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 768490011231 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490011232 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 768490011233 dimerization interface [polypeptide binding]; other site 768490011234 substrate binding pocket [chemical binding]; other site 768490011235 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768490011236 EamA-like transporter family; Region: EamA; pfam00892 768490011237 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 768490011238 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 768490011239 Transglycosylase SLT domain; Region: SLT_2; pfam13406 768490011240 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768490011241 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768490011242 catalytic residue [active] 768490011243 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 768490011244 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 768490011245 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 768490011246 aminotransferase; Validated; Region: PRK08175 768490011247 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768490011248 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490011249 homodimer interface [polypeptide binding]; other site 768490011250 catalytic residue [active] 768490011251 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 768490011252 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768490011253 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 768490011254 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 768490011255 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 768490011256 GAF domain; Region: GAF; pfam01590 768490011257 Histidine kinase; Region: His_kinase; pfam06580 768490011258 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490011259 ATP binding site [chemical binding]; other site 768490011260 Mg2+ binding site [ion binding]; other site 768490011261 G-X-G motif; other site 768490011262 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 768490011263 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490011264 active site 768490011265 phosphorylation site [posttranslational modification] 768490011266 intermolecular recognition site; other site 768490011267 dimerization interface [polypeptide binding]; other site 768490011268 LytTr DNA-binding domain; Region: LytTR; pfam04397 768490011269 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 768490011270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490011271 putative substrate translocation pore; other site 768490011272 glucokinase, proteobacterial type; Region: glk; TIGR00749 768490011273 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768490011274 nucleotide binding site [chemical binding]; other site 768490011275 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 768490011276 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 768490011277 Cl- selectivity filter; other site 768490011278 Cl- binding residues [ion binding]; other site 768490011279 pore gating glutamate residue; other site 768490011280 dimer interface [polypeptide binding]; other site 768490011281 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 768490011282 aspartate racemase; Region: asp_race; TIGR00035 768490011283 Predicted membrane protein [Function unknown]; Region: COG4125 768490011284 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 768490011285 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 768490011286 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490011287 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490011288 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768490011289 dimerization interface [polypeptide binding]; other site 768490011290 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 768490011291 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 768490011292 dimer interface [polypeptide binding]; other site 768490011293 PYR/PP interface [polypeptide binding]; other site 768490011294 TPP binding site [chemical binding]; other site 768490011295 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768490011296 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 768490011297 TPP-binding site [chemical binding]; other site 768490011298 dimer interface [polypeptide binding]; other site 768490011299 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768490011300 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768490011301 active site 768490011302 catalytic tetrad [active] 768490011303 manganese transport protein MntH; Reviewed; Region: PRK00701 768490011304 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 768490011305 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 768490011306 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 768490011307 Nucleoside recognition; Region: Gate; pfam07670 768490011308 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 768490011309 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 768490011310 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 768490011311 HIGH motif; other site 768490011312 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 768490011313 active site 768490011314 KMSKS motif; other site 768490011315 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 768490011316 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 768490011317 putative NAD(P) binding site [chemical binding]; other site 768490011318 active site 768490011319 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 768490011320 hydrophobic substrate binding pocket; other site 768490011321 Isochorismatase family; Region: Isochorismatase; pfam00857 768490011322 active site 768490011323 conserved cis-peptide bond; other site 768490011324 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 768490011325 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 768490011326 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 768490011327 acyl-activating enzyme (AAE) consensus motif; other site 768490011328 active site 768490011329 AMP binding site [chemical binding]; other site 768490011330 substrate binding site [chemical binding]; other site 768490011331 isochorismate synthase EntC; Provisional; Region: PRK15016 768490011332 chorismate binding enzyme; Region: Chorismate_bind; cl10555 768490011333 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 768490011334 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 768490011335 siderophore binding site; other site 768490011336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490011337 H+ Antiporter protein; Region: 2A0121; TIGR00900 768490011338 putative substrate translocation pore; other site 768490011339 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 768490011340 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 768490011341 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768490011342 ABC-ATPase subunit interface; other site 768490011343 dimer interface [polypeptide binding]; other site 768490011344 putative PBP binding regions; other site 768490011345 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 768490011346 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768490011347 ABC-ATPase subunit interface; other site 768490011348 dimer interface [polypeptide binding]; other site 768490011349 putative PBP binding regions; other site 768490011350 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 768490011351 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768490011352 Walker A/P-loop; other site 768490011353 ATP binding site [chemical binding]; other site 768490011354 Q-loop/lid; other site 768490011355 ABC transporter signature motif; other site 768490011356 Walker B; other site 768490011357 D-loop; other site 768490011358 H-loop/switch region; other site 768490011359 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 768490011360 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 768490011361 acyl-activating enzyme (AAE) consensus motif; other site 768490011362 AMP binding site [chemical binding]; other site 768490011363 MbtH-like protein; Region: MbtH; cl01279 768490011364 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 768490011365 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 768490011366 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 768490011367 outer membrane receptor FepA; Provisional; Region: PRK13524 768490011368 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768490011369 N-terminal plug; other site 768490011370 ligand-binding site [chemical binding]; other site 768490011371 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 768490011372 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 768490011373 peptide binding site [polypeptide binding]; other site 768490011374 acetolactate synthase; Reviewed; Region: PRK08617 768490011375 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768490011376 PYR/PP interface [polypeptide binding]; other site 768490011377 dimer interface [polypeptide binding]; other site 768490011378 TPP binding site [chemical binding]; other site 768490011379 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768490011380 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 768490011381 TPP-binding site [chemical binding]; other site 768490011382 dimer interface [polypeptide binding]; other site 768490011383 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 768490011384 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490011385 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490011386 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768490011387 putative effector binding pocket; other site 768490011388 dimerization interface [polypeptide binding]; other site 768490011389 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 768490011390 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 768490011391 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 768490011392 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 768490011393 FlxA-like protein; Region: FlxA; pfam14282 768490011394 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490011395 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490011396 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 768490011397 putative dimerization interface [polypeptide binding]; other site 768490011398 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 768490011399 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 768490011400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 768490011401 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 768490011402 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 768490011403 nucleotide binding pocket [chemical binding]; other site 768490011404 K-X-D-G motif; other site 768490011405 catalytic site [active] 768490011406 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 768490011407 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 768490011408 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 768490011409 Dimer interface [polypeptide binding]; other site 768490011410 BRCT sequence motif; other site 768490011411 cell division protein ZipA; Provisional; Region: PRK03427 768490011412 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 768490011413 FtsZ protein binding site [polypeptide binding]; other site 768490011414 putative sulfate transport protein CysZ; Validated; Region: PRK04949 768490011415 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 768490011416 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 768490011417 dimer interface [polypeptide binding]; other site 768490011418 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490011419 catalytic residue [active] 768490011420 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 768490011421 dimerization domain swap beta strand [polypeptide binding]; other site 768490011422 regulatory protein interface [polypeptide binding]; other site 768490011423 active site 768490011424 regulatory phosphorylation site [posttranslational modification]; other site 768490011425 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 768490011426 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 768490011427 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 768490011428 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 768490011429 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 768490011430 HPr interaction site; other site 768490011431 glycerol kinase (GK) interaction site [polypeptide binding]; other site 768490011432 active site 768490011433 phosphorylation site [posttranslational modification] 768490011434 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 768490011435 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768490011436 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768490011437 dimerization interface [polypeptide binding]; other site 768490011438 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768490011439 dimer interface [polypeptide binding]; other site 768490011440 phosphorylation site [posttranslational modification] 768490011441 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490011442 ATP binding site [chemical binding]; other site 768490011443 Mg2+ binding site [ion binding]; other site 768490011444 G-X-G motif; other site 768490011445 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768490011446 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490011447 active site 768490011448 phosphorylation site [posttranslational modification] 768490011449 intermolecular recognition site; other site 768490011450 dimerization interface [polypeptide binding]; other site 768490011451 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768490011452 DNA binding site [nucleotide binding] 768490011453 macrolide transporter subunit MacA; Provisional; Region: PRK11578 768490011454 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768490011455 HlyD family secretion protein; Region: HlyD_3; pfam13437 768490011456 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 768490011457 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768490011458 Walker A/P-loop; other site 768490011459 ATP binding site [chemical binding]; other site 768490011460 Q-loop/lid; other site 768490011461 ABC transporter signature motif; other site 768490011462 Walker B; other site 768490011463 D-loop; other site 768490011464 H-loop/switch region; other site 768490011465 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768490011466 FtsX-like permease family; Region: FtsX; pfam02687 768490011467 cysteine synthase B; Region: cysM; TIGR01138 768490011468 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 768490011469 dimer interface [polypeptide binding]; other site 768490011470 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490011471 catalytic residue [active] 768490011472 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 768490011473 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 768490011474 Walker A/P-loop; other site 768490011475 ATP binding site [chemical binding]; other site 768490011476 Q-loop/lid; other site 768490011477 ABC transporter signature motif; other site 768490011478 Walker B; other site 768490011479 D-loop; other site 768490011480 H-loop/switch region; other site 768490011481 TOBE-like domain; Region: TOBE_3; pfam12857 768490011482 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 768490011483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490011484 dimer interface [polypeptide binding]; other site 768490011485 conserved gate region; other site 768490011486 putative PBP binding loops; other site 768490011487 ABC-ATPase subunit interface; other site 768490011488 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 768490011489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490011490 dimer interface [polypeptide binding]; other site 768490011491 conserved gate region; other site 768490011492 putative PBP binding loops; other site 768490011493 ABC-ATPase subunit interface; other site 768490011494 thiosulfate transporter subunit; Provisional; Region: PRK10852 768490011495 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 768490011496 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 768490011497 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 768490011498 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 768490011499 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 768490011500 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 768490011501 putative acetyltransferase; Provisional; Region: PRK03624 768490011502 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490011503 Coenzyme A binding pocket [chemical binding]; other site 768490011504 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 768490011505 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 768490011506 active site 768490011507 metal binding site [ion binding]; metal-binding site 768490011508 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 768490011509 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 768490011510 hypothetical protein; Validated; Region: PRK00124 768490011511 Protein of unknown function, DUF399; Region: DUF399; pfam04187 768490011512 S-methylmethionine transporter; Provisional; Region: PRK11387 768490011513 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 768490011514 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 768490011515 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 768490011516 Malic enzyme, N-terminal domain; Region: malic; pfam00390 768490011517 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 768490011518 putative NAD(P) binding site [chemical binding]; other site 768490011519 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 768490011520 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 768490011521 Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106 768490011522 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 768490011523 Glyco_18 domain; Region: Glyco_18; smart00636 768490011524 active site 768490011525 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 768490011526 transcriptional regulator, ArgP family; Region: argP; TIGR03298 768490011527 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490011528 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768490011529 dimerization interface [polypeptide binding]; other site 768490011530 Chitin binding domain; Region: Chitin_bind_3; pfam03067 768490011531 transaldolase-like protein; Provisional; Region: PTZ00411 768490011532 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 768490011533 active site 768490011534 dimer interface [polypeptide binding]; other site 768490011535 catalytic residue [active] 768490011536 transketolase; Reviewed; Region: PRK12753 768490011537 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 768490011538 TPP-binding site [chemical binding]; other site 768490011539 dimer interface [polypeptide binding]; other site 768490011540 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 768490011541 PYR/PP interface [polypeptide binding]; other site 768490011542 dimer interface [polypeptide binding]; other site 768490011543 TPP binding site [chemical binding]; other site 768490011544 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768490011545 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 768490011546 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 768490011547 dimer interface [polypeptide binding]; other site 768490011548 ADP-ribose binding site [chemical binding]; other site 768490011549 active site 768490011550 nudix motif; other site 768490011551 metal binding site [ion binding]; metal-binding site 768490011552 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 768490011553 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 768490011554 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 768490011555 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 768490011556 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 768490011557 [4Fe-4S] binding site [ion binding]; other site 768490011558 molybdopterin cofactor binding site; other site 768490011559 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 768490011560 molybdopterin cofactor binding site; other site 768490011561 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 768490011562 ferredoxin-type protein NapF; Region: napF; TIGR00402 768490011563 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768490011564 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 768490011565 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 768490011566 HAMP domain; Region: HAMP; pfam00672 768490011567 dimerization interface [polypeptide binding]; other site 768490011568 Histidine kinase; Region: HisKA_3; pfam07730 768490011569 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490011570 ATP binding site [chemical binding]; other site 768490011571 Mg2+ binding site [ion binding]; other site 768490011572 G-X-G motif; other site 768490011573 transcriptional regulator NarP; Provisional; Region: PRK10403 768490011574 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490011575 active site 768490011576 phosphorylation site [posttranslational modification] 768490011577 intermolecular recognition site; other site 768490011578 dimerization interface [polypeptide binding]; other site 768490011579 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768490011580 DNA binding residues [nucleotide binding] 768490011581 dimerization interface [polypeptide binding]; other site 768490011582 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4519 768490011583 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 768490011584 Protein export membrane protein; Region: SecD_SecF; cl14618 768490011585 putative outer membrane receptor; Provisional; Region: PRK13513 768490011586 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768490011587 N-terminal plug; other site 768490011588 ligand-binding site [chemical binding]; other site 768490011589 Uncharacterized conserved protein [Function unknown]; Region: COG3391 768490011590 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 768490011591 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768490011592 N-terminal plug; other site 768490011593 ligand-binding site [chemical binding]; other site 768490011594 Tetratrico peptide repeat; Region: TPR_5; pfam12688 768490011595 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768490011596 binding surface 768490011597 TPR motif; other site 768490011598 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490011599 Coenzyme A binding pocket [chemical binding]; other site 768490011600 Chorismate mutase type II; Region: CM_2; cl00693 768490011601 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768490011602 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 768490011603 ArsC family; Region: ArsC; pfam03960 768490011604 putative catalytic residues [active] 768490011605 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 768490011606 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 768490011607 metal binding site [ion binding]; metal-binding site 768490011608 dimer interface [polypeptide binding]; other site 768490011609 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 768490011610 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 768490011611 Uncharacterized protein family (UPF0370); Region: UPF0370; pfam13980 768490011612 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 768490011613 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 768490011614 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 768490011615 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 768490011616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 768490011617 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 768490011618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 768490011619 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 768490011620 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 768490011621 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 768490011622 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 768490011623 putative hydrolase; Provisional; Region: PRK11460 768490011624 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 768490011625 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 768490011626 Helicase; Region: Helicase_RecD; pfam05127 768490011627 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 768490011628 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 768490011629 Predicted metalloprotease [General function prediction only]; Region: COG2321 768490011630 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 768490011631 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 768490011632 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 768490011633 ATP binding site [chemical binding]; other site 768490011634 active site 768490011635 substrate binding site [chemical binding]; other site 768490011636 lipoprotein; Provisional; Region: PRK11679 768490011637 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 768490011638 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 768490011639 dihydrodipicolinate synthase; Region: dapA; TIGR00674 768490011640 dimer interface [polypeptide binding]; other site 768490011641 active site 768490011642 catalytic residue [active] 768490011643 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 768490011644 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 768490011645 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 768490011646 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 768490011647 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 768490011648 catalytic triad [active] 768490011649 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 768490011650 Domain of unknown function DUF20; Region: UPF0118; pfam01594 768490011651 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 768490011652 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 768490011653 MoaE homodimer interface [polypeptide binding]; other site 768490011654 MoaD interaction [polypeptide binding]; other site 768490011655 active site residues [active] 768490011656 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 768490011657 MoaE interaction surface [polypeptide binding]; other site 768490011658 MoeB interaction surface [polypeptide binding]; other site 768490011659 thiocarboxylated glycine; other site 768490011660 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 768490011661 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768490011662 FeS/SAM binding site; other site 768490011663 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 768490011664 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 768490011665 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 768490011666 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 768490011667 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 768490011668 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 768490011669 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 768490011670 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 768490011671 putative molybdopterin cofactor binding site [chemical binding]; other site 768490011672 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 768490011673 putative molybdopterin cofactor binding site; other site 768490011674 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 768490011675 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768490011676 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768490011677 putative DNA binding site [nucleotide binding]; other site 768490011678 putative Zn2+ binding site [ion binding]; other site 768490011679 AsnC family; Region: AsnC_trans_reg; pfam01037 768490011680 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 768490011681 Predicted transcriptional regulator [Transcription]; Region: COG1959 768490011682 Transcriptional regulator; Region: Rrf2; pfam02082 768490011683 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 768490011684 Peptidase family M48; Region: Peptidase_M48; pfam01435 768490011685 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 768490011686 ArsC family; Region: ArsC; pfam03960 768490011687 catalytic residues [active] 768490011688 DNA replication initiation factor; Provisional; Region: PRK08084 768490011689 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 768490011690 hypothetical protein; Provisional; Region: PRK10457 768490011691 uracil transporter; Provisional; Region: PRK10720 768490011692 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768490011693 active site 768490011694 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 768490011695 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 768490011696 dimerization interface [polypeptide binding]; other site 768490011697 putative ATP binding site [chemical binding]; other site 768490011698 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 768490011699 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 768490011700 active site 768490011701 substrate binding site [chemical binding]; other site 768490011702 cosubstrate binding site; other site 768490011703 catalytic site [active] 768490011704 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 768490011705 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 768490011706 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490011707 Coenzyme A binding pocket [chemical binding]; other site 768490011708 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3792 768490011709 haemagglutination activity domain; Region: Haemagg_act; pfam05860 768490011710 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 768490011711 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 768490011712 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 768490011713 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 768490011714 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 768490011715 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 768490011716 Walker A/P-loop; other site 768490011717 ATP binding site [chemical binding]; other site 768490011718 Q-loop/lid; other site 768490011719 ABC transporter signature motif; other site 768490011720 Walker B; other site 768490011721 D-loop; other site 768490011722 H-loop/switch region; other site 768490011723 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 768490011724 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 768490011725 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490011726 dimer interface [polypeptide binding]; other site 768490011727 conserved gate region; other site 768490011728 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 768490011729 ABC-ATPase subunit interface; other site 768490011730 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 768490011731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490011732 conserved gate region; other site 768490011733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490011734 conserved gate region; other site 768490011735 putative PBP binding loops; other site 768490011736 ABC-ATPase subunit interface; other site 768490011737 polyphosphate kinase; Provisional; Region: PRK05443 768490011738 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 768490011739 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 768490011740 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 768490011741 domain interface [polypeptide binding]; other site 768490011742 active site 768490011743 catalytic site [active] 768490011744 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 768490011745 domain interface [polypeptide binding]; other site 768490011746 active site 768490011747 catalytic site [active] 768490011748 exopolyphosphatase; Provisional; Region: PRK10854 768490011749 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 768490011750 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 768490011751 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 768490011752 MgtE intracellular N domain; Region: MgtE_N; smart00924 768490011753 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 768490011754 Divalent cation transporter; Region: MgtE; pfam01769 768490011755 putative diguanylate cyclase; Provisional; Region: PRK09776 768490011756 MASE1; Region: MASE1; cl17823 768490011757 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768490011758 putative active site [active] 768490011759 heme pocket [chemical binding]; other site 768490011760 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768490011761 putative active site [active] 768490011762 heme pocket [chemical binding]; other site 768490011763 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768490011764 putative active site [active] 768490011765 heme pocket [chemical binding]; other site 768490011766 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768490011767 metal binding site [ion binding]; metal-binding site 768490011768 active site 768490011769 I-site; other site 768490011770 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768490011771 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 768490011772 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 768490011773 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 768490011774 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490011775 AlkA N-terminal domain; Region: AlkA_N; pfam06029 768490011776 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 768490011777 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 768490011778 minor groove reading motif; other site 768490011779 helix-hairpin-helix signature motif; other site 768490011780 substrate binding pocket [chemical binding]; other site 768490011781 active site 768490011782 putative chaperone; Provisional; Region: PRK11678 768490011783 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 768490011784 nucleotide binding site [chemical binding]; other site 768490011785 putative NEF/HSP70 interaction site [polypeptide binding]; other site 768490011786 SBD interface [polypeptide binding]; other site 768490011787 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768490011788 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768490011789 Predicted kinase [General function prediction only]; Region: COG0645 768490011790 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 768490011791 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768490011792 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768490011793 active site 768490011794 catalytic tetrad [active] 768490011795 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 768490011796 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768490011797 HlyD family secretion protein; Region: HlyD_3; pfam13437 768490011798 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 768490011799 Protein export membrane protein; Region: SecD_SecF; cl14618 768490011800 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 768490011801 putative transporter; Provisional; Region: PRK10504 768490011802 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490011803 putative substrate translocation pore; other site 768490011804 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 768490011805 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768490011806 dimerization interface [polypeptide binding]; other site 768490011807 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768490011808 dimer interface [polypeptide binding]; other site 768490011809 phosphorylation site [posttranslational modification] 768490011810 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490011811 ATP binding site [chemical binding]; other site 768490011812 Mg2+ binding site [ion binding]; other site 768490011813 G-X-G motif; other site 768490011814 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 768490011815 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490011816 active site 768490011817 phosphorylation site [posttranslational modification] 768490011818 intermolecular recognition site; other site 768490011819 dimerization interface [polypeptide binding]; other site 768490011820 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768490011821 DNA binding site [nucleotide binding] 768490011822 Uncharacterized conserved protein [Function unknown]; Region: COG3422 768490011823 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 768490011824 putative protease; Provisional; Region: PRK15452 768490011825 Peptidase family U32; Region: Peptidase_U32; pfam01136 768490011826 lipid kinase; Reviewed; Region: PRK13054 768490011827 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 768490011828 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 768490011829 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 768490011830 putative active site pocket [active] 768490011831 putative metal binding site [ion binding]; other site 768490011832 putative oxidoreductase; Provisional; Region: PRK10083 768490011833 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 768490011834 putative NAD(P) binding site [chemical binding]; other site 768490011835 catalytic Zn binding site [ion binding]; other site 768490011836 structural Zn binding site [ion binding]; other site 768490011837 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490011838 D-galactonate transporter; Region: 2A0114; TIGR00893 768490011839 putative substrate translocation pore; other site 768490011840 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 768490011841 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 768490011842 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 768490011843 Transcriptional regulators [Transcription]; Region: GntR; COG1802 768490011844 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768490011845 DNA-binding site [nucleotide binding]; DNA binding site 768490011846 FCD domain; Region: FCD; pfam07729 768490011847 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 768490011848 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 768490011849 putative active site; other site 768490011850 catalytic residue [active] 768490011851 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 768490011852 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 768490011853 putative active site [active] 768490011854 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 768490011855 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816 768490011856 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 768490011857 dimer interface [polypeptide binding]; other site 768490011858 substrate binding site [chemical binding]; other site 768490011859 ATP binding site [chemical binding]; other site 768490011860 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 768490011861 substrate binding site [chemical binding]; other site 768490011862 multimerization interface [polypeptide binding]; other site 768490011863 ATP binding site [chemical binding]; other site 768490011864 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 768490011865 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490011866 Coenzyme A binding pocket [chemical binding]; other site 768490011867 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490011868 S-adenosylmethionine binding site [chemical binding]; other site 768490011869 Predicted transcriptional regulators [Transcription]; Region: COG1733 768490011870 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 768490011871 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 768490011872 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768490011873 RNA binding surface [nucleotide binding]; other site 768490011874 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 768490011875 probable active site [active] 768490011876 Autotransporter beta-domain; Region: Autotransporter; pfam03797 768490011877 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768490011878 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490011879 active site 768490011880 phosphorylation site [posttranslational modification] 768490011881 intermolecular recognition site; other site 768490011882 dimerization interface [polypeptide binding]; other site 768490011883 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768490011884 DNA binding residues [nucleotide binding] 768490011885 dimerization interface [polypeptide binding]; other site 768490011886 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768490011887 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768490011888 dimer interface [polypeptide binding]; other site 768490011889 phosphorylation site [posttranslational modification] 768490011890 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490011891 ATP binding site [chemical binding]; other site 768490011892 Mg2+ binding site [ion binding]; other site 768490011893 G-X-G motif; other site 768490011894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490011895 Response regulator receiver domain; Region: Response_reg; pfam00072 768490011896 active site 768490011897 phosphorylation site [posttranslational modification] 768490011898 intermolecular recognition site; other site 768490011899 dimerization interface [polypeptide binding]; other site 768490011900 enoyl-CoA hydratase; Provisional; Region: PRK06688 768490011901 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768490011902 substrate binding site [chemical binding]; other site 768490011903 oxyanion hole (OAH) forming residues; other site 768490011904 trimer interface [polypeptide binding]; other site 768490011905 Predicted transcriptional regulators [Transcription]; Region: COG1733 768490011906 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 768490011907 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768490011908 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490011909 Coenzyme A binding pocket [chemical binding]; other site 768490011910 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768490011911 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768490011912 putative DNA binding site [nucleotide binding]; other site 768490011913 putative Zn2+ binding site [ion binding]; other site 768490011914 AsnC family; Region: AsnC_trans_reg; pfam01037 768490011915 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 768490011916 Bacterial sugar transferase; Region: Bac_transf; pfam02397 768490011917 Protein of unknown function (DUF342); Region: DUF342; pfam03961 768490011918 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 768490011919 GMP synthase; Reviewed; Region: guaA; PRK00074 768490011920 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 768490011921 AMP/PPi binding site [chemical binding]; other site 768490011922 candidate oxyanion hole; other site 768490011923 catalytic triad [active] 768490011924 potential glutamine specificity residues [chemical binding]; other site 768490011925 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 768490011926 ATP Binding subdomain [chemical binding]; other site 768490011927 Ligand Binding sites [chemical binding]; other site 768490011928 Dimerization subdomain; other site 768490011929 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 768490011930 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 768490011931 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 768490011932 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 768490011933 active site 768490011934 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 768490011935 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 768490011936 generic binding surface II; other site 768490011937 generic binding surface I; other site 768490011938 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 768490011939 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 768490011940 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 768490011941 putative active site [active] 768490011942 putative catalytic site [active] 768490011943 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490011944 D-galactonate transporter; Region: 2A0114; TIGR00893 768490011945 putative substrate translocation pore; other site 768490011946 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768490011947 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768490011948 DNA binding site [nucleotide binding] 768490011949 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 768490011950 ligand binding site [chemical binding]; other site 768490011951 dimerization interface [polypeptide binding]; other site 768490011952 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 768490011953 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 768490011954 active site 768490011955 Zn binding site [ion binding]; other site 768490011956 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 768490011957 Predicted permeases [General function prediction only]; Region: COG0679 768490011958 GTP-binding protein Der; Reviewed; Region: PRK00093 768490011959 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 768490011960 G1 box; other site 768490011961 GTP/Mg2+ binding site [chemical binding]; other site 768490011962 Switch I region; other site 768490011963 G2 box; other site 768490011964 Switch II region; other site 768490011965 G3 box; other site 768490011966 G4 box; other site 768490011967 G5 box; other site 768490011968 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 768490011969 G1 box; other site 768490011970 GTP/Mg2+ binding site [chemical binding]; other site 768490011971 Switch I region; other site 768490011972 G2 box; other site 768490011973 G3 box; other site 768490011974 Switch II region; other site 768490011975 G4 box; other site 768490011976 G5 box; other site 768490011977 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 768490011978 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 768490011979 Trp docking motif [polypeptide binding]; other site 768490011980 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 768490011981 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 768490011982 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 768490011983 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 768490011984 dimer interface [polypeptide binding]; other site 768490011985 motif 1; other site 768490011986 active site 768490011987 motif 2; other site 768490011988 motif 3; other site 768490011989 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 768490011990 anticodon binding site; other site 768490011991 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 768490011992 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 768490011993 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 768490011994 cytoskeletal protein RodZ; Provisional; Region: PRK10856 768490011995 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768490011996 non-specific DNA binding site [nucleotide binding]; other site 768490011997 salt bridge; other site 768490011998 sequence-specific DNA binding site [nucleotide binding]; other site 768490011999 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 768490012000 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 768490012001 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768490012002 binding surface 768490012003 TPR motif; other site 768490012004 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 768490012005 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768490012006 FeS/SAM binding site; other site 768490012007 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 768490012008 active site 768490012009 multimer interface [polypeptide binding]; other site 768490012010 penicillin-binding protein 1C; Provisional; Region: PRK11240 768490012011 Transglycosylase; Region: Transgly; pfam00912 768490012012 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 768490012013 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 768490012014 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 768490012015 MG2 domain; Region: A2M_N; pfam01835 768490012016 Alpha-2-macroglobulin family; Region: A2M; pfam00207 768490012017 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 768490012018 surface patch; other site 768490012019 thioester region; other site 768490012020 specificity defining residues; other site 768490012021 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 768490012022 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768490012023 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768490012024 active site turn [active] 768490012025 phosphorylation site [posttranslational modification] 768490012026 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 768490012027 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 768490012028 NAD binding site [chemical binding]; other site 768490012029 sugar binding site [chemical binding]; other site 768490012030 divalent metal binding site [ion binding]; other site 768490012031 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 768490012032 dimer interface [polypeptide binding]; other site 768490012033 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 768490012034 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768490012035 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768490012036 putative active site [active] 768490012037 SseB protein; Region: SseB; pfam07179 768490012038 aminopeptidase B; Provisional; Region: PRK05015 768490012039 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 768490012040 interface (dimer of trimers) [polypeptide binding]; other site 768490012041 Substrate-binding/catalytic site; other site 768490012042 Zn-binding sites [ion binding]; other site 768490012043 hypothetical protein; Provisional; Region: PRK10721 768490012044 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 768490012045 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768490012046 catalytic loop [active] 768490012047 iron binding site [ion binding]; other site 768490012048 chaperone protein HscA; Provisional; Region: hscA; PRK05183 768490012049 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 768490012050 nucleotide binding site [chemical binding]; other site 768490012051 putative NEF/HSP70 interaction site [polypeptide binding]; other site 768490012052 SBD interface [polypeptide binding]; other site 768490012053 co-chaperone HscB; Provisional; Region: hscB; PRK05014 768490012054 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 768490012055 HSP70 interaction site [polypeptide binding]; other site 768490012056 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 768490012057 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 768490012058 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 768490012059 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 768490012060 trimerization site [polypeptide binding]; other site 768490012061 active site 768490012062 cysteine desulfurase; Provisional; Region: PRK14012 768490012063 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 768490012064 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768490012065 catalytic residue [active] 768490012066 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 768490012067 Rrf2 family protein; Region: rrf2_super; TIGR00738 768490012068 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 768490012069 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 768490012070 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 768490012071 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 768490012072 active site 768490012073 dimerization interface [polypeptide binding]; other site 768490012074 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 768490012075 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 768490012076 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 768490012077 PRD domain; Region: PRD; pfam00874 768490012078 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 768490012079 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490012080 putative substrate translocation pore; other site 768490012081 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 768490012082 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 768490012083 dimer interface [polypeptide binding]; other site 768490012084 active site 768490012085 glycine-pyridoxal phosphate binding site [chemical binding]; other site 768490012086 folate binding site [chemical binding]; other site 768490012087 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 768490012088 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 768490012089 heme-binding site [chemical binding]; other site 768490012090 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 768490012091 FAD binding pocket [chemical binding]; other site 768490012092 FAD binding motif [chemical binding]; other site 768490012093 phosphate binding motif [ion binding]; other site 768490012094 beta-alpha-beta structure motif; other site 768490012095 NAD binding pocket [chemical binding]; other site 768490012096 Heme binding pocket [chemical binding]; other site 768490012097 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 768490012098 Nitrogen regulatory protein P-II; Region: P-II; smart00938 768490012099 NAD synthetase; Provisional; Region: PRK13981 768490012100 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 768490012101 multimer interface [polypeptide binding]; other site 768490012102 active site 768490012103 catalytic triad [active] 768490012104 protein interface 1 [polypeptide binding]; other site 768490012105 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 768490012106 homodimer interface [polypeptide binding]; other site 768490012107 NAD binding pocket [chemical binding]; other site 768490012108 ATP binding pocket [chemical binding]; other site 768490012109 Mg binding site [ion binding]; other site 768490012110 active-site loop [active] 768490012111 response regulator GlrR; Provisional; Region: PRK15115 768490012112 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490012113 active site 768490012114 phosphorylation site [posttranslational modification] 768490012115 intermolecular recognition site; other site 768490012116 dimerization interface [polypeptide binding]; other site 768490012117 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768490012118 Walker A motif; other site 768490012119 ATP binding site [chemical binding]; other site 768490012120 Walker B motif; other site 768490012121 arginine finger; other site 768490012122 hypothetical protein; Provisional; Region: PRK10722 768490012123 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768490012124 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768490012125 dimer interface [polypeptide binding]; other site 768490012126 phosphorylation site [posttranslational modification] 768490012127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490012128 ATP binding site [chemical binding]; other site 768490012129 Mg2+ binding site [ion binding]; other site 768490012130 G-X-G motif; other site 768490012131 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 768490012132 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 768490012133 dimerization interface [polypeptide binding]; other site 768490012134 ATP binding site [chemical binding]; other site 768490012135 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 768490012136 dimerization interface [polypeptide binding]; other site 768490012137 ATP binding site [chemical binding]; other site 768490012138 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 768490012139 putative active site [active] 768490012140 catalytic triad [active] 768490012141 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 768490012142 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768490012143 substrate binding pocket [chemical binding]; other site 768490012144 membrane-bound complex binding site; other site 768490012145 hinge residues; other site 768490012146 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768490012147 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768490012148 catalytic residue [active] 768490012149 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 768490012150 nucleoside/Zn binding site; other site 768490012151 dimer interface [polypeptide binding]; other site 768490012152 catalytic motif [active] 768490012153 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 768490012154 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768490012155 active site turn [active] 768490012156 phosphorylation site [posttranslational modification] 768490012157 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768490012158 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 768490012159 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 768490012160 putative active site [active] 768490012161 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768490012162 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 768490012163 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768490012164 putative active site [active] 768490012165 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 768490012166 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 768490012167 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 768490012168 active site 768490012169 hydrophilic channel; other site 768490012170 dimerization interface [polypeptide binding]; other site 768490012171 catalytic residues [active] 768490012172 active site lid [active] 768490012173 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 768490012174 Recombination protein O N terminal; Region: RecO_N; pfam11967 768490012175 Recombination protein O C terminal; Region: RecO_C; pfam02565 768490012176 GTPase Era; Reviewed; Region: era; PRK00089 768490012177 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 768490012178 G1 box; other site 768490012179 GTP/Mg2+ binding site [chemical binding]; other site 768490012180 Switch I region; other site 768490012181 G2 box; other site 768490012182 Switch II region; other site 768490012183 G3 box; other site 768490012184 G4 box; other site 768490012185 G5 box; other site 768490012186 KH domain; Region: KH_2; pfam07650 768490012187 ribonuclease III; Reviewed; Region: rnc; PRK00102 768490012188 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 768490012189 dimerization interface [polypeptide binding]; other site 768490012190 active site 768490012191 metal binding site [ion binding]; metal-binding site 768490012192 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 768490012193 dsRNA binding site [nucleotide binding]; other site 768490012194 signal peptidase I; Provisional; Region: PRK10861 768490012195 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 768490012196 Catalytic site [active] 768490012197 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 768490012198 GTP-binding protein LepA; Provisional; Region: PRK05433 768490012199 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 768490012200 G1 box; other site 768490012201 putative GEF interaction site [polypeptide binding]; other site 768490012202 GTP/Mg2+ binding site [chemical binding]; other site 768490012203 Switch I region; other site 768490012204 G2 box; other site 768490012205 G3 box; other site 768490012206 Switch II region; other site 768490012207 G4 box; other site 768490012208 G5 box; other site 768490012209 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 768490012210 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 768490012211 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 768490012212 SoxR reducing system protein RseC; Provisional; Region: PRK10862 768490012213 anti-sigma E factor; Provisional; Region: rseB; PRK09455 768490012214 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 768490012215 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 768490012216 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 768490012217 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 768490012218 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 768490012219 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768490012220 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768490012221 DNA binding residues [nucleotide binding] 768490012222 L-aspartate oxidase; Provisional; Region: PRK09077 768490012223 L-aspartate oxidase; Provisional; Region: PRK06175 768490012224 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 768490012225 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 768490012226 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490012227 S-adenosylmethionine binding site [chemical binding]; other site 768490012228 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 768490012229 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 768490012230 ATP binding site [chemical binding]; other site 768490012231 Mg++ binding site [ion binding]; other site 768490012232 motif III; other site 768490012233 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768490012234 nucleotide binding region [chemical binding]; other site 768490012235 ATP-binding site [chemical binding]; other site 768490012236 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 768490012237 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 768490012238 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 768490012239 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 768490012240 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 768490012241 ligand binding site [chemical binding]; other site 768490012242 active site 768490012243 UGI interface [polypeptide binding]; other site 768490012244 catalytic site [active] 768490012245 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 768490012246 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 768490012247 dimer interface [polypeptide binding]; other site 768490012248 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 768490012249 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 768490012250 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 768490012251 recombination and repair protein; Provisional; Region: PRK10869 768490012252 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 768490012253 Walker A/P-loop; other site 768490012254 ATP binding site [chemical binding]; other site 768490012255 Q-loop/lid; other site 768490012256 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 768490012257 ABC transporter signature motif; other site 768490012258 Walker B; other site 768490012259 D-loop; other site 768490012260 H-loop/switch region; other site 768490012261 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 768490012262 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 768490012263 hypothetical protein; Validated; Region: PRK01777 768490012264 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 768490012265 putative coenzyme Q binding site [chemical binding]; other site 768490012266 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 768490012267 SmpB-tmRNA interface; other site 768490012268 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490012269 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490012270 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768490012271 dimerization interface [polypeptide binding]; other site 768490012272 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 768490012273 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 768490012274 potential catalytic triad [active] 768490012275 conserved cys residue [active] 768490012276 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768490012277 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768490012278 active site 768490012279 catalytic tetrad [active] 768490012280 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 768490012281 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 768490012282 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 768490012283 Uncharacterized conserved protein [Function unknown]; Region: COG1359 768490012284 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 768490012285 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 768490012286 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 768490012287 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 768490012288 putative NAD(P) binding site [chemical binding]; other site 768490012289 Predicted transcriptional regulator [Transcription]; Region: COG2378 768490012290 HTH domain; Region: HTH_11; pfam08279 768490012291 WYL domain; Region: WYL; cl14852 768490012292 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490012293 Coenzyme A binding pocket [chemical binding]; other site 768490012294 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490012295 S-adenosylmethionine binding site [chemical binding]; other site 768490012296 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 768490012297 Predicted acetyltransferase [General function prediction only]; Region: COG2388 768490012298 Predicted membrane protein [Function unknown]; Region: COG2259 768490012299 MbeD/MobD like; Region: MbeD_MobD; pfam04899 768490012300 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 768490012301 hypothetical protein; Provisional; Region: PRK10556 768490012302 major facilitator superfamily transporter; Provisional; Region: PRK05122 768490012303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490012304 putative substrate translocation pore; other site 768490012305 Helix-turn-helix domain; Region: HTH_18; pfam12833 768490012306 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490012307 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 768490012308 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490012309 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490012310 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768490012311 putative effector binding pocket; other site 768490012312 dimerization interface [polypeptide binding]; other site 768490012313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490012314 putative substrate translocation pore; other site 768490012315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490012316 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 768490012317 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 768490012318 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768490012319 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768490012320 DNA-binding site [nucleotide binding]; DNA binding site 768490012321 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768490012322 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490012323 homodimer interface [polypeptide binding]; other site 768490012324 catalytic residue [active] 768490012325 Uncharacterized conserved protein [Function unknown]; Region: COG2128 768490012326 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 768490012327 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 768490012328 catalytic residues [active] 768490012329 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 768490012330 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 768490012331 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 768490012332 Class I ribonucleotide reductase; Region: RNR_I; cd01679 768490012333 active site 768490012334 dimer interface [polypeptide binding]; other site 768490012335 catalytic residues [active] 768490012336 effector binding site; other site 768490012337 R2 peptide binding site; other site 768490012338 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 768490012339 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 768490012340 dimer interface [polypeptide binding]; other site 768490012341 putative radical transfer pathway; other site 768490012342 diiron center [ion binding]; other site 768490012343 tyrosyl radical; other site 768490012344 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 768490012345 HicB family; Region: HicB; pfam05534 768490012346 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 768490012347 short chain dehydrogenase; Provisional; Region: PRK12937 768490012348 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 768490012349 NADP binding site [chemical binding]; other site 768490012350 homodimer interface [polypeptide binding]; other site 768490012351 active site 768490012352 substrate binding site [chemical binding]; other site 768490012353 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490012354 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490012355 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 768490012356 putative effector binding pocket; other site 768490012357 putative dimerization interface [polypeptide binding]; other site 768490012358 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 768490012359 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 768490012360 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 768490012361 active site 768490012362 nucleophile elbow; other site 768490012363 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 768490012364 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 768490012365 PAS domain; Region: PAS; smart00091 768490012366 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490012367 ATP binding site [chemical binding]; other site 768490012368 Mg2+ binding site [ion binding]; other site 768490012369 G-X-G motif; other site 768490012370 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 768490012371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490012372 active site 768490012373 phosphorylation site [posttranslational modification] 768490012374 intermolecular recognition site; other site 768490012375 dimerization interface [polypeptide binding]; other site 768490012376 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 768490012377 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 768490012378 Walker A/P-loop; other site 768490012379 ATP binding site [chemical binding]; other site 768490012380 Q-loop/lid; other site 768490012381 ABC transporter signature motif; other site 768490012382 Walker B; other site 768490012383 D-loop; other site 768490012384 H-loop/switch region; other site 768490012385 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 768490012386 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 768490012387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490012388 dimer interface [polypeptide binding]; other site 768490012389 conserved gate region; other site 768490012390 putative PBP binding loops; other site 768490012391 ABC-ATPase subunit interface; other site 768490012392 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 768490012393 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 768490012394 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 768490012395 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 768490012396 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490012397 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490012398 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 768490012399 putative dimerization interface [polypeptide binding]; other site 768490012400 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490012401 putative substrate translocation pore; other site 768490012402 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768490012403 transcriptional repressor MprA; Provisional; Region: PRK10870 768490012404 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768490012405 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 768490012406 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 768490012407 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768490012408 HlyD family secretion protein; Region: HlyD_3; pfam13437 768490012409 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 768490012410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490012411 putative substrate translocation pore; other site 768490012412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490012413 putative methyltransferase; Provisional; Region: PRK10864 768490012414 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 768490012415 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 768490012416 thioredoxin 2; Provisional; Region: PRK10996 768490012417 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 768490012418 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 768490012419 catalytic residues [active] 768490012420 Uncharacterized conserved protein [Function unknown]; Region: COG3148 768490012421 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 768490012422 CoA binding domain; Region: CoA_binding_2; pfam13380 768490012423 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 768490012424 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 768490012425 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768490012426 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490012427 Coenzyme A binding pocket [chemical binding]; other site 768490012428 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 768490012429 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 768490012430 domain interface [polypeptide binding]; other site 768490012431 putative active site [active] 768490012432 catalytic site [active] 768490012433 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 768490012434 domain interface [polypeptide binding]; other site 768490012435 putative active site [active] 768490012436 catalytic site [active] 768490012437 lipoprotein; Provisional; Region: PRK10759 768490012438 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 768490012439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490012440 putative substrate translocation pore; other site 768490012441 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 768490012442 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768490012443 active site 768490012444 motif I; other site 768490012445 motif II; other site 768490012446 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 768490012447 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 768490012448 Walker A/P-loop; other site 768490012449 ATP binding site [chemical binding]; other site 768490012450 Q-loop/lid; other site 768490012451 ABC transporter signature motif; other site 768490012452 Walker B; other site 768490012453 D-loop; other site 768490012454 H-loop/switch region; other site 768490012455 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 768490012456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490012457 dimer interface [polypeptide binding]; other site 768490012458 conserved gate region; other site 768490012459 ABC-ATPase subunit interface; other site 768490012460 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 768490012461 lipoprotein, YaeC family; Region: TIGR00363 768490012462 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 768490012463 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 768490012464 homodimer interaction site [polypeptide binding]; other site 768490012465 cofactor binding site; other site 768490012466 prolyl-tRNA synthetase; Provisional; Region: PRK09194 768490012467 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 768490012468 dimer interface [polypeptide binding]; other site 768490012469 motif 1; other site 768490012470 active site 768490012471 motif 2; other site 768490012472 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 768490012473 putative deacylase active site [active] 768490012474 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 768490012475 active site 768490012476 motif 3; other site 768490012477 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 768490012478 anticodon binding site; other site 768490012479 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 768490012480 NlpE N-terminal domain; Region: NlpE; pfam04170 768490012481 hypothetical protein; Provisional; Region: PRK09256 768490012482 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 768490012483 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 768490012484 hypothetical protein; Provisional; Region: PRK04964 768490012485 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 768490012486 Cytochrome c; Region: Cytochrom_C; cl11414 768490012487 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 768490012488 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 768490012489 Ligand Binding Site [chemical binding]; other site 768490012490 TilS substrate binding domain; Region: TilS; pfam09179 768490012491 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 768490012492 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 768490012493 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768490012494 putative metal binding site [ion binding]; other site 768490012495 lysine decarboxylase LdcC; Provisional; Region: PRK15399 768490012496 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 768490012497 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 768490012498 homodimer interface [polypeptide binding]; other site 768490012499 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490012500 catalytic residue [active] 768490012501 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 768490012502 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 768490012503 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 768490012504 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 768490012505 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 768490012506 putative active site [active] 768490012507 putative PHP Thumb interface [polypeptide binding]; other site 768490012508 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 768490012509 generic binding surface II; other site 768490012510 generic binding surface I; other site 768490012511 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 768490012512 RNA/DNA hybrid binding site [nucleotide binding]; other site 768490012513 active site 768490012514 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 768490012515 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 768490012516 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 768490012517 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 768490012518 active site 768490012519 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 768490012520 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 768490012521 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 768490012522 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 768490012523 trimer interface [polypeptide binding]; other site 768490012524 active site 768490012525 UDP-GlcNAc binding site [chemical binding]; other site 768490012526 lipid binding site [chemical binding]; lipid-binding site 768490012527 periplasmic chaperone; Provisional; Region: PRK10780 768490012528 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 768490012529 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 768490012530 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768490012531 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768490012532 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768490012533 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768490012534 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768490012535 Surface antigen; Region: Bac_surface_Ag; pfam01103 768490012536 zinc metallopeptidase RseP; Provisional; Region: PRK10779 768490012537 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 768490012538 active site 768490012539 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 768490012540 protein binding site [polypeptide binding]; other site 768490012541 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 768490012542 protein binding site [polypeptide binding]; other site 768490012543 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 768490012544 putative substrate binding region [chemical binding]; other site 768490012545 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 768490012546 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 768490012547 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 768490012548 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 768490012549 catalytic residue [active] 768490012550 putative FPP diphosphate binding site; other site 768490012551 putative FPP binding hydrophobic cleft; other site 768490012552 dimer interface [polypeptide binding]; other site 768490012553 putative IPP diphosphate binding site; other site 768490012554 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 768490012555 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 768490012556 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 768490012557 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 768490012558 ribosome recycling factor; Reviewed; Region: frr; PRK00083 768490012559 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 768490012560 hinge region; other site 768490012561 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 768490012562 putative nucleotide binding site [chemical binding]; other site 768490012563 uridine monophosphate binding site [chemical binding]; other site 768490012564 homohexameric interface [polypeptide binding]; other site 768490012565 elongation factor Ts; Provisional; Region: tsf; PRK09377 768490012566 UBA/TS-N domain; Region: UBA; pfam00627 768490012567 Elongation factor TS; Region: EF_TS; pfam00889 768490012568 Elongation factor TS; Region: EF_TS; pfam00889 768490012569 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 768490012570 rRNA interaction site [nucleotide binding]; other site 768490012571 S8 interaction site; other site 768490012572 putative laminin-1 binding site; other site 768490012573 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 768490012574 active site 768490012575 PII uridylyl-transferase; Provisional; Region: PRK05007 768490012576 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 768490012577 metal binding triad; other site 768490012578 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 768490012579 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768490012580 Zn2+ binding site [ion binding]; other site 768490012581 Mg2+ binding site [ion binding]; other site 768490012582 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 768490012583 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 768490012584 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 768490012585 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 768490012586 trimer interface [polypeptide binding]; other site 768490012587 active site 768490012588 substrate binding site [chemical binding]; other site 768490012589 CoA binding site [chemical binding]; other site 768490012590 hypothetical protein; Provisional; Region: PRK13677 768490012591 flavodoxin; Provisional; Region: PRK08105 768490012592 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 768490012593 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 768490012594 probable active site [active] 768490012595 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 768490012596 benzoate transport; Region: 2A0115; TIGR00895 768490012597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490012598 putative substrate translocation pore; other site 768490012599 SecY interacting protein Syd; Provisional; Region: PRK04968 768490012600 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 768490012601 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 768490012602 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 768490012603 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 768490012604 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 768490012605 flap endonuclease-like protein; Provisional; Region: PRK09482 768490012606 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 768490012607 active site 768490012608 metal binding site 1 [ion binding]; metal-binding site 768490012609 putative 5' ssDNA interaction site; other site 768490012610 metal binding site 3; metal-binding site 768490012611 metal binding site 2 [ion binding]; metal-binding site 768490012612 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 768490012613 putative DNA binding site [nucleotide binding]; other site 768490012614 putative metal binding site [ion binding]; other site 768490012615 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 768490012616 FtsJ-like methyltransferase; Region: FtsJ; cl17430 768490012617 hypothetical protein; Provisional; Region: PRK10873 768490012618 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768490012619 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490012620 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 768490012621 dimerization interface [polypeptide binding]; other site 768490012622 substrate binding pocket [chemical binding]; other site 768490012623 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 768490012624 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 768490012625 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 768490012626 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768490012627 catalytic residue [active] 768490012628 cysteine desulfurase, sulfur acceptor subunit CsdE; Region: FeS_syn_CsdE; TIGR03391 768490012629 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 768490012630 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 768490012631 putative ATP binding site [chemical binding]; other site 768490012632 putative substrate interface [chemical binding]; other site 768490012633 murein transglycosylase A; Provisional; Region: mltA; PRK11162 768490012634 MltA specific insert domain; Region: MltA; smart00925 768490012635 3D domain; Region: 3D; pfam06725 768490012636 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 768490012637 AMIN domain; Region: AMIN; pfam11741 768490012638 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 768490012639 active site 768490012640 metal binding site [ion binding]; metal-binding site 768490012641 N-acetylglutamate synthase; Validated; Region: PRK05279 768490012642 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 768490012643 putative feedback inhibition sensing region; other site 768490012644 putative nucleotide binding site [chemical binding]; other site 768490012645 putative substrate binding site [chemical binding]; other site 768490012646 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490012647 Coenzyme A binding pocket [chemical binding]; other site 768490012648 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 768490012649 AAA domain; Region: AAA_30; pfam13604 768490012650 Family description; Region: UvrD_C_2; pfam13538 768490012651 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 768490012652 protease3; Provisional; Region: PRK15101 768490012653 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 768490012654 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 768490012655 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 768490012656 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 768490012657 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 768490012658 hypothetical protein; Provisional; Region: PRK10332 768490012659 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 768490012660 Protein of unknown function (DUF2509); Region: DUF2509; cl11672 768490012661 hypothetical protein; Provisional; Region: PRK10557 768490012662 hypothetical protein; Provisional; Region: PRK10506 768490012663 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 768490012664 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 768490012665 thymidylate synthase; Reviewed; Region: thyA; PRK01827 768490012666 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 768490012667 dimerization interface [polypeptide binding]; other site 768490012668 active site 768490012669 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 768490012670 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 768490012671 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 768490012672 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 768490012673 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 768490012674 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 768490012675 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 768490012676 putative active site [active] 768490012677 Ap4A binding site [chemical binding]; other site 768490012678 nudix motif; other site 768490012679 putative metal binding site [ion binding]; other site 768490012680 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 768490012681 putative DNA-binding cleft [nucleotide binding]; other site 768490012682 putative DNA clevage site; other site 768490012683 molecular lever; other site 768490012684 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 768490012685 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 768490012686 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768490012687 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768490012688 active site 768490012689 catalytic tetrad [active] 768490012690 lysophospholipid transporter LplT; Provisional; Region: PRK11195 768490012691 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490012692 putative substrate translocation pore; other site 768490012693 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 768490012694 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 768490012695 putative acyl-acceptor binding pocket; other site 768490012696 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 768490012697 acyl-activating enzyme (AAE) consensus motif; other site 768490012698 putative AMP binding site [chemical binding]; other site 768490012699 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 768490012700 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 768490012701 molybdopterin cofactor binding site [chemical binding]; other site 768490012702 substrate binding site [chemical binding]; other site 768490012703 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 768490012704 molybdopterin cofactor binding site; other site 768490012705 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 768490012706 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768490012707 DNA binding site [nucleotide binding] 768490012708 domain linker motif; other site 768490012709 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 768490012710 dimerization interface (closed form) [polypeptide binding]; other site 768490012711 ligand binding site [chemical binding]; other site 768490012712 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490012713 Coenzyme A binding pocket [chemical binding]; other site 768490012714 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768490012715 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768490012716 DNA binding site [nucleotide binding] 768490012717 domain linker motif; other site 768490012718 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 768490012719 dimerization interface (closed form) [polypeptide binding]; other site 768490012720 ligand binding site [chemical binding]; other site 768490012721 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768490012722 sequence-specific DNA binding site [nucleotide binding]; other site 768490012723 salt bridge; other site 768490012724 diaminopimelate decarboxylase; Provisional; Region: PRK11165 768490012725 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 768490012726 active site 768490012727 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768490012728 substrate binding site [chemical binding]; other site 768490012729 catalytic residues [active] 768490012730 dimer interface [polypeptide binding]; other site 768490012731 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 768490012732 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490012733 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768490012734 dimerization interface [polypeptide binding]; other site 768490012735 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490012736 putative substrate translocation pore; other site 768490012737 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768490012738 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490012739 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490012740 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768490012741 putative effector binding pocket; other site 768490012742 dimerization interface [polypeptide binding]; other site 768490012743 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 768490012744 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 768490012745 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 768490012746 catalytic residues [active] 768490012747 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 768490012748 TPR motif; other site 768490012749 binding surface 768490012750 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 768490012751 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 768490012752 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 768490012753 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 768490012754 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 768490012755 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 768490012756 Walker A/P-loop; other site 768490012757 ATP binding site [chemical binding]; other site 768490012758 Q-loop/lid; other site 768490012759 ABC transporter signature motif; other site 768490012760 Walker B; other site 768490012761 D-loop; other site 768490012762 H-loop/switch region; other site 768490012763 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768490012764 active site 768490012765 DNA binding site [nucleotide binding] 768490012766 Int/Topo IB signature motif; other site 768490012767 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768490012768 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768490012769 DNA binding residues [nucleotide binding] 768490012770 dimerization interface [polypeptide binding]; other site 768490012771 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768490012772 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 768490012773 intermolecular recognition site; other site 768490012774 active site 768490012775 dimerization interface [polypeptide binding]; other site 768490012776 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768490012777 DNA binding residues [nucleotide binding] 768490012778 dimerization interface [polypeptide binding]; other site 768490012779 Fimbrial protein; Region: Fimbrial; cl01416 768490012780 Fimbrial protein; Region: Fimbrial; cl01416 768490012781 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 768490012782 PapC N-terminal domain; Region: PapC_N; pfam13954 768490012783 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 768490012784 PapC C-terminal domain; Region: PapC_C; pfam13953 768490012785 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 768490012786 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 768490012787 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 768490012788 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 768490012789 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768490012790 active site 768490012791 DNA binding site [nucleotide binding] 768490012792 Int/Topo IB signature motif; other site 768490012793 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768490012794 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 768490012795 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 768490012796 dimer interface [polypeptide binding]; other site 768490012797 active site 768490012798 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 768490012799 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 768490012800 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768490012801 Walker A/P-loop; other site 768490012802 ATP binding site [chemical binding]; other site 768490012803 Q-loop/lid; other site 768490012804 ABC transporter signature motif; other site 768490012805 Walker B; other site 768490012806 D-loop; other site 768490012807 H-loop/switch region; other site 768490012808 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768490012809 FtsX-like permease family; Region: FtsX; pfam02687 768490012810 macrolide transporter subunit MacA; Provisional; Region: PRK11578 768490012811 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768490012812 HlyD family secretion protein; Region: HlyD_3; pfam13437 768490012813 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 768490012814 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 768490012815 putative active site [active] 768490012816 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768490012817 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768490012818 Walker A/P-loop; other site 768490012819 ATP binding site [chemical binding]; other site 768490012820 Q-loop/lid; other site 768490012821 ABC transporter signature motif; other site 768490012822 Walker B; other site 768490012823 D-loop; other site 768490012824 H-loop/switch region; other site 768490012825 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 768490012826 catalytic residues [active] 768490012827 hinge region; other site 768490012828 alpha helical domain; other site 768490012829 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490012830 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490012831 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768490012832 putative effector binding pocket; other site 768490012833 dimerization interface [polypeptide binding]; other site 768490012834 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 768490012835 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 768490012836 phosphate binding site [ion binding]; other site 768490012837 BCCT family transporter; Region: BCCT; pfam02028 768490012838 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 768490012839 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768490012840 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 768490012841 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490012842 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490012843 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768490012844 putative effector binding pocket; other site 768490012845 dimerization interface [polypeptide binding]; other site 768490012846 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 768490012847 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768490012848 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 768490012849 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 768490012850 Walker A/P-loop; other site 768490012851 ATP binding site [chemical binding]; other site 768490012852 Q-loop/lid; other site 768490012853 ABC transporter signature motif; other site 768490012854 Walker B; other site 768490012855 D-loop; other site 768490012856 H-loop/switch region; other site 768490012857 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 768490012858 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 768490012859 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 768490012860 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768490012861 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768490012862 Cytochrome c; Region: Cytochrom_C; pfam00034 768490012863 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 768490012864 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768490012865 Peptidase family M23; Region: Peptidase_M23; pfam01551 768490012866 acid-resistance membrane protein; Provisional; Region: PRK10209 768490012867 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 768490012868 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 768490012869 HSP70 interaction site [polypeptide binding]; other site 768490012870 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 768490012871 substrate binding site [polypeptide binding]; other site 768490012872 dimer interface [polypeptide binding]; other site 768490012873 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 768490012874 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 768490012875 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490012876 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490012877 LysR substrate binding domain; Region: LysR_substrate; pfam03466 768490012878 dimerization interface [polypeptide binding]; other site 768490012879 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 768490012880 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 768490012881 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 768490012882 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768490012883 DNA-binding site [nucleotide binding]; DNA binding site 768490012884 RNA-binding motif; other site 768490012885 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 768490012886 Excisionase-like protein; Region: Exc; pfam07825 768490012887 Excisionase-like protein; Region: Exc; pfam07825 768490012888 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 768490012889 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 768490012890 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 768490012891 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 768490012892 AntA/AntB antirepressor; Region: AntA; pfam08346 768490012893 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 768490012894 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 768490012895 integrase; Provisional; Region: PRK09692 768490012896 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 768490012897 active site 768490012898 Int/Topo IB signature motif; other site 768490012899 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 768490012900 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 768490012901 dimer interface [polypeptide binding]; other site 768490012902 putative anticodon binding site; other site 768490012903 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 768490012904 motif 1; other site 768490012905 active site 768490012906 motif 2; other site 768490012907 motif 3; other site 768490012908 peptide chain release factor 2; Validated; Region: prfB; PRK00578 768490012909 This domain is found in peptide chain release factors; Region: PCRF; smart00937 768490012910 RF-1 domain; Region: RF-1; pfam00472 768490012911 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 768490012912 DHH family; Region: DHH; pfam01368 768490012913 DHHA1 domain; Region: DHHA1; pfam02272 768490012914 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 768490012915 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 768490012916 dimerization domain [polypeptide binding]; other site 768490012917 dimer interface [polypeptide binding]; other site 768490012918 catalytic residues [active] 768490012919 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 768490012920 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 768490012921 active site 768490012922 Int/Topo IB signature motif; other site 768490012923 flavodoxin FldB; Provisional; Region: PRK12359 768490012924 Inner membrane protein CreD; Region: CreD; pfam06123 768490012925 sensory histidine kinase CreC; Provisional; Region: PRK11100 768490012926 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768490012927 dimerization interface [polypeptide binding]; other site 768490012928 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768490012929 dimer interface [polypeptide binding]; other site 768490012930 phosphorylation site [posttranslational modification] 768490012931 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490012932 ATP binding site [chemical binding]; other site 768490012933 Mg2+ binding site [ion binding]; other site 768490012934 G-X-G motif; other site 768490012935 DNA-binding response regulator CreB; Provisional; Region: PRK11083 768490012936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490012937 active site 768490012938 phosphorylation site [posttranslational modification] 768490012939 intermolecular recognition site; other site 768490012940 dimerization interface [polypeptide binding]; other site 768490012941 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768490012942 DNA binding site [nucleotide binding] 768490012943 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 768490012944 hypothetical protein; Provisional; Region: PRK10878 768490012945 putative global regulator; Reviewed; Region: PRK09559 768490012946 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 768490012947 hemolysin; Provisional; Region: PRK15087 768490012948 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 768490012949 HD domain; Region: HD_3; pfam13023 768490012950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490012951 metabolite-proton symporter; Region: 2A0106; TIGR00883 768490012952 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490012953 amidase; Provisional; Region: PRK07056 768490012954 Amidase; Region: Amidase; cl11426 768490012955 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 768490012956 Transcriptional regulators [Transcription]; Region: GntR; COG1802 768490012957 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768490012958 DNA-binding site [nucleotide binding]; DNA binding site 768490012959 FCD domain; Region: FCD; pfam07729 768490012960 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 768490012961 classical (c) SDRs; Region: SDR_c; cd05233 768490012962 NAD(P) binding site [chemical binding]; other site 768490012963 active site 768490012964 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 768490012965 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 768490012966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490012967 active site 768490012968 phosphorylation site [posttranslational modification] 768490012969 intermolecular recognition site; other site 768490012970 dimerization interface [polypeptide binding]; other site 768490012971 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768490012972 DNA binding site [nucleotide binding] 768490012973 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768490012974 dimer interface [polypeptide binding]; other site 768490012975 phosphorylation site [posttranslational modification] 768490012976 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490012977 ATP binding site [chemical binding]; other site 768490012978 Mg2+ binding site [ion binding]; other site 768490012979 G-X-G motif; other site 768490012980 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 768490012981 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 768490012982 NAD(P) binding site [chemical binding]; other site 768490012983 glycine dehydrogenase; Provisional; Region: PRK05367 768490012984 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 768490012985 tetramer interface [polypeptide binding]; other site 768490012986 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490012987 catalytic residue [active] 768490012988 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 768490012989 tetramer interface [polypeptide binding]; other site 768490012990 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490012991 catalytic residue [active] 768490012992 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 768490012993 lipoyl attachment site [posttranslational modification]; other site 768490012994 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 768490012995 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 768490012996 oxidoreductase; Provisional; Region: PRK08013 768490012997 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 768490012998 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 768490012999 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 768490013000 proline aminopeptidase P II; Provisional; Region: PRK10879 768490013001 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 768490013002 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 768490013003 active site 768490013004 hypothetical protein; Reviewed; Region: PRK01736 768490013005 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 768490013006 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 768490013007 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 768490013008 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 768490013009 ligand binding site [chemical binding]; other site 768490013010 NAD binding site [chemical binding]; other site 768490013011 tetramer interface [polypeptide binding]; other site 768490013012 catalytic site [active] 768490013013 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 768490013014 L-serine binding site [chemical binding]; other site 768490013015 ACT domain interface; other site 768490013016 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 768490013017 tetramer (dimer of dimers) interface [polypeptide binding]; other site 768490013018 active site 768490013019 dimer interface [polypeptide binding]; other site 768490013020 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 768490013021 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490013022 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 768490013023 putative dimerization interface [polypeptide binding]; other site 768490013024 oxidative stress defense protein; Provisional; Region: PRK11087 768490013025 Uncharacterized conserved protein [Function unknown]; Region: COG2968 768490013026 arginine exporter protein; Provisional; Region: PRK09304 768490013027 Transcriptional regulator [Transcription]; Region: IclR; COG1414 768490013028 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 768490013029 Bacterial transcriptional regulator; Region: IclR; pfam01614 768490013030 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 768490013031 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768490013032 Walker A/P-loop; other site 768490013033 ATP binding site [chemical binding]; other site 768490013034 Q-loop/lid; other site 768490013035 ABC transporter signature motif; other site 768490013036 Walker B; other site 768490013037 D-loop; other site 768490013038 H-loop/switch region; other site 768490013039 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768490013040 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768490013041 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768490013042 TM-ABC transporter signature motif; other site 768490013043 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_6; cd06315 768490013044 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 768490013045 putative ligand binding site [chemical binding]; other site 768490013046 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 768490013047 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 768490013048 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 768490013049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490013050 D-galactonate transporter; Region: 2A0114; TIGR00893 768490013051 putative substrate translocation pore; other site 768490013052 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 768490013053 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 768490013054 putative N- and C-terminal domain interface [polypeptide binding]; other site 768490013055 putative active site [active] 768490013056 MgATP binding site [chemical binding]; other site 768490013057 catalytic site [active] 768490013058 metal binding site [ion binding]; metal-binding site 768490013059 putative xylulose binding site [chemical binding]; other site 768490013060 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 768490013061 active site 768490013062 dimer interface [polypeptide binding]; other site 768490013063 magnesium binding site [ion binding]; other site 768490013064 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 768490013065 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 768490013066 AP (apurinic/apyrimidinic) site pocket; other site 768490013067 DNA interaction; other site 768490013068 Metal-binding active site; metal-binding site 768490013069 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 768490013070 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 768490013071 intersubunit interface [polypeptide binding]; other site 768490013072 active site 768490013073 Zn2+ binding site [ion binding]; other site 768490013074 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 768490013075 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 768490013076 active site 768490013077 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 768490013078 mechanosensitive channel MscS; Provisional; Region: PRK10334 768490013079 Mechanosensitive ion channel; Region: MS_channel; pfam00924 768490013080 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 768490013081 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 768490013082 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 768490013083 active site 768490013084 intersubunit interface [polypeptide binding]; other site 768490013085 zinc binding site [ion binding]; other site 768490013086 Na+ binding site [ion binding]; other site 768490013087 Phosphoglycerate kinase; Region: PGK; pfam00162 768490013088 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 768490013089 substrate binding site [chemical binding]; other site 768490013090 hinge regions; other site 768490013091 ADP binding site [chemical binding]; other site 768490013092 catalytic site [active] 768490013093 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 768490013094 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 768490013095 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 768490013096 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 768490013097 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768490013098 Walker A/P-loop; other site 768490013099 ATP binding site [chemical binding]; other site 768490013100 Q-loop/lid; other site 768490013101 ABC transporter signature motif; other site 768490013102 Walker B; other site 768490013103 D-loop; other site 768490013104 H-loop/switch region; other site 768490013105 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 768490013106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490013107 dimer interface [polypeptide binding]; other site 768490013108 conserved gate region; other site 768490013109 ABC-ATPase subunit interface; other site 768490013110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490013111 dimer interface [polypeptide binding]; other site 768490013112 conserved gate region; other site 768490013113 putative PBP binding loops; other site 768490013114 ABC-ATPase subunit interface; other site 768490013115 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 768490013116 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 768490013117 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768490013118 catalytic core [active] 768490013119 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 768490013120 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 768490013121 transmembrane helices; other site 768490013122 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490013123 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490013124 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 768490013125 putative dimerization interface [polypeptide binding]; other site 768490013126 transketolase; Reviewed; Region: PRK12753 768490013127 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 768490013128 TPP-binding site [chemical binding]; other site 768490013129 dimer interface [polypeptide binding]; other site 768490013130 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 768490013131 PYR/PP interface [polypeptide binding]; other site 768490013132 dimer interface [polypeptide binding]; other site 768490013133 TPP binding site [chemical binding]; other site 768490013134 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768490013135 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 768490013136 hypothetical protein; Provisional; Region: PRK07064 768490013137 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768490013138 PYR/PP interface [polypeptide binding]; other site 768490013139 dimer interface [polypeptide binding]; other site 768490013140 TPP binding site [chemical binding]; other site 768490013141 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768490013142 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 768490013143 TPP-binding site [chemical binding]; other site 768490013144 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 768490013145 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 768490013146 NAD(P) binding site [chemical binding]; other site 768490013147 catalytic residues [active] 768490013148 L-aspartate dehydrogenase; Provisional; Region: PRK13303 768490013149 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 768490013150 Domain of unknown function DUF108; Region: DUF108; pfam01958 768490013151 short chain dehydrogenase; Provisional; Region: PRK07062 768490013152 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768490013153 NAD(P) binding site [chemical binding]; other site 768490013154 active site 768490013155 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 768490013156 Cupin domain; Region: Cupin_2; pfam07883 768490013157 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490013158 D-galactonate transporter; Region: 2A0114; TIGR00893 768490013159 putative substrate translocation pore; other site 768490013160 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 768490013161 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768490013162 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 768490013163 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768490013164 putative active site [active] 768490013165 putative metal binding site [ion binding]; other site 768490013166 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 768490013167 Transcriptional regulator [Transcription]; Region: IclR; COG1414 768490013168 Bacterial transcriptional regulator; Region: IclR; pfam01614 768490013169 short chain dehydrogenase; Provisional; Region: PRK12939 768490013170 classical (c) SDRs; Region: SDR_c; cd05233 768490013171 NAD(P) binding site [chemical binding]; other site 768490013172 active site 768490013173 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 768490013174 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 768490013175 [2Fe-2S] cluster binding site [ion binding]; other site 768490013176 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 768490013177 hydrophobic ligand binding site; other site 768490013178 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 768490013179 [2Fe-2S] cluster binding site [ion binding]; other site 768490013180 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 768490013181 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768490013182 RNA binding surface [nucleotide binding]; other site 768490013183 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 768490013184 probable active site [active] 768490013185 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 768490013186 agmatinase; Region: agmatinase; TIGR01230 768490013187 oligomer interface [polypeptide binding]; other site 768490013188 putative active site [active] 768490013189 Mn binding site [ion binding]; other site 768490013190 arginine decarboxylase; Provisional; Region: PRK05354 768490013191 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 768490013192 dimer interface [polypeptide binding]; other site 768490013193 active site 768490013194 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768490013195 catalytic residues [active] 768490013196 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 768490013197 S-adenosylmethionine synthetase; Validated; Region: PRK05250 768490013198 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 768490013199 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 768490013200 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 768490013201 Hok/gef family; Region: HOK_GEF; pfam01848 768490013202 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 768490013203 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768490013204 ABC-ATPase subunit interface; other site 768490013205 dimer interface [polypeptide binding]; other site 768490013206 putative PBP binding regions; other site 768490013207 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768490013208 ABC-ATPase subunit interface; other site 768490013209 dimer interface [polypeptide binding]; other site 768490013210 putative PBP binding regions; other site 768490013211 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 768490013212 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 768490013213 siderophore binding site; other site 768490013214 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 768490013215 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768490013216 Walker A/P-loop; other site 768490013217 ATP binding site [chemical binding]; other site 768490013218 Q-loop/lid; other site 768490013219 ABC transporter signature motif; other site 768490013220 Walker B; other site 768490013221 D-loop; other site 768490013222 H-loop/switch region; other site 768490013223 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 768490013224 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768490013225 N-terminal plug; other site 768490013226 ligand-binding site [chemical binding]; other site 768490013227 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 768490013228 Transglycosylase; Region: Transgly; pfam00912 768490013229 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 768490013230 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 768490013231 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768490013232 ATP binding site [chemical binding]; other site 768490013233 putative Mg++ binding site [ion binding]; other site 768490013234 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768490013235 nucleotide binding region [chemical binding]; other site 768490013236 ATP-binding site [chemical binding]; other site 768490013237 Helicase associated domain (HA2); Region: HA2; pfam04408 768490013238 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 768490013239 2'-5' RNA ligase; Provisional; Region: PRK15124 768490013240 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 768490013241 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 768490013242 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 768490013243 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 768490013244 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 768490013245 active site 768490013246 nucleotide binding site [chemical binding]; other site 768490013247 HIGH motif; other site 768490013248 KMSKS motif; other site 768490013249 poly(A) polymerase; Region: pcnB; TIGR01942 768490013250 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 768490013251 active site 768490013252 NTP binding site [chemical binding]; other site 768490013253 metal binding triad [ion binding]; metal-binding site 768490013254 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 768490013255 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 768490013256 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 768490013257 catalytic center binding site [active] 768490013258 ATP binding site [chemical binding]; other site 768490013259 sensor protein QseC; Provisional; Region: PRK10337 768490013260 HAMP domain; Region: HAMP; pfam00672 768490013261 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768490013262 dimer interface [polypeptide binding]; other site 768490013263 phosphorylation site [posttranslational modification] 768490013264 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490013265 ATP binding site [chemical binding]; other site 768490013266 Mg2+ binding site [ion binding]; other site 768490013267 G-X-G motif; other site 768490013268 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 768490013269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490013270 active site 768490013271 phosphorylation site [posttranslational modification] 768490013272 intermolecular recognition site; other site 768490013273 dimerization interface [polypeptide binding]; other site 768490013274 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768490013275 DNA binding site [nucleotide binding] 768490013276 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 768490013277 oligomerization interface [polypeptide binding]; other site 768490013278 active site 768490013279 metal binding site [ion binding]; metal-binding site 768490013280 Pantoate-beta-alanine ligase; Region: PanC; cd00560 768490013281 pantoate--beta-alanine ligase; Region: panC; TIGR00018 768490013282 active site 768490013283 ATP-binding site [chemical binding]; other site 768490013284 pantoate-binding site; other site 768490013285 HXXH motif; other site 768490013286 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 768490013287 tetramerization interface [polypeptide binding]; other site 768490013288 active site 768490013289 Bacterial SH3 domain; Region: SH3_3; cl17532 768490013290 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 768490013291 putative active site [active] 768490013292 putative metal binding site [ion binding]; other site 768490013293 inner membrane transport permease; Provisional; Region: PRK15066 768490013294 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 768490013295 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 768490013296 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 768490013297 Walker A/P-loop; other site 768490013298 ATP binding site [chemical binding]; other site 768490013299 Q-loop/lid; other site 768490013300 ABC transporter signature motif; other site 768490013301 Walker B; other site 768490013302 D-loop; other site 768490013303 H-loop/switch region; other site 768490013304 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 768490013305 active site clefts [active] 768490013306 zinc binding site [ion binding]; other site 768490013307 dimer interface [polypeptide binding]; other site 768490013308 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768490013309 active site 768490013310 multicopper oxidase; Provisional; Region: PRK10965 768490013311 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 768490013312 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 768490013313 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 768490013314 spermidine synthase; Provisional; Region: PRK00811 768490013315 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490013316 S-adenosylmethionine binding site [chemical binding]; other site 768490013317 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 768490013318 hypothetical protein; Provisional; Region: PRK05248 768490013319 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 768490013320 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 768490013321 substrate binding site [chemical binding]; other site 768490013322 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 768490013323 substrate binding site [chemical binding]; other site 768490013324 ligand binding site [chemical binding]; other site 768490013325 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 768490013326 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768490013327 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768490013328 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768490013329 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 768490013330 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768490013331 E3 interaction surface; other site 768490013332 lipoyl attachment site [posttranslational modification]; other site 768490013333 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768490013334 E3 interaction surface; other site 768490013335 lipoyl attachment site [posttranslational modification]; other site 768490013336 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768490013337 E3 interaction surface; other site 768490013338 lipoyl attachment site [posttranslational modification]; other site 768490013339 e3 binding domain; Region: E3_binding; pfam02817 768490013340 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 768490013341 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 768490013342 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 768490013343 dimer interface [polypeptide binding]; other site 768490013344 TPP-binding site [chemical binding]; other site 768490013345 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 768490013346 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768490013347 DNA-binding site [nucleotide binding]; DNA binding site 768490013348 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 768490013349 aromatic amino acid transporter; Provisional; Region: PRK10238 768490013350 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 768490013351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490013352 putative substrate translocation pore; other site 768490013353 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 768490013354 active site 768490013355 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768490013356 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768490013357 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 768490013358 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 768490013359 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 768490013360 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 768490013361 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 768490013362 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768490013363 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 768490013364 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768490013365 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 768490013366 Ligand binding site; other site 768490013367 metal-binding site 768490013368 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 768490013369 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 768490013370 XdhC Rossmann domain; Region: XdhC_C; pfam13478 768490013371 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 768490013372 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490013373 fumarate hydratase; Provisional; Region: PRK15389 768490013374 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 768490013375 Fumarase C-terminus; Region: Fumerase_C; pfam05683 768490013376 hypothetical protein; Provisional; Region: PRK04860 768490013377 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 768490013378 DNA-specific endonuclease I; Provisional; Region: PRK15137 768490013379 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 768490013380 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 768490013381 RNA methyltransferase, RsmE family; Region: TIGR00046 768490013382 glutathione synthetase; Provisional; Region: PRK05246 768490013383 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 768490013384 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 768490013385 hypothetical protein; Validated; Region: PRK00228 768490013386 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 768490013387 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 768490013388 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 768490013389 Walker A motif; other site 768490013390 ATP binding site [chemical binding]; other site 768490013391 Walker B motif; other site 768490013392 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 768490013393 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768490013394 catalytic residue [active] 768490013395 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 768490013396 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 768490013397 YGGT family; Region: YGGT; pfam02325 768490013398 YGGT family; Region: YGGT; pfam02325 768490013399 hypothetical protein; Validated; Region: PRK05090 768490013400 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 768490013401 active site 768490013402 dimerization interface [polypeptide binding]; other site 768490013403 HemN family oxidoreductase; Provisional; Region: PRK05660 768490013404 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768490013405 FeS/SAM binding site; other site 768490013406 HemN C-terminal domain; Region: HemN_C; pfam06969 768490013407 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 768490013408 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 768490013409 hypothetical protein; Provisional; Region: PRK10626 768490013410 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 768490013411 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 768490013412 glutaminase; Provisional; Region: PRK00971 768490013413 hypothetical protein; Provisional; Region: PRK11702 768490013414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490013415 S-adenosylmethionine binding site [chemical binding]; other site 768490013416 adenine DNA glycosylase; Provisional; Region: PRK10880 768490013417 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 768490013418 minor groove reading motif; other site 768490013419 helix-hairpin-helix signature motif; other site 768490013420 substrate binding pocket [chemical binding]; other site 768490013421 active site 768490013422 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 768490013423 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 768490013424 DNA binding and oxoG recognition site [nucleotide binding] 768490013425 oxidative damage protection protein; Provisional; Region: PRK05408 768490013426 murein transglycosylase C; Provisional; Region: mltC; PRK11671 768490013427 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 768490013428 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768490013429 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768490013430 catalytic residue [active] 768490013431 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 768490013432 2-methylcitrate dehydratase; Region: prpD; TIGR02330 768490013433 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 768490013434 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 768490013435 dimer interface [polypeptide binding]; other site 768490013436 active site 768490013437 citrylCoA binding site [chemical binding]; other site 768490013438 oxalacetate/citrate binding site [chemical binding]; other site 768490013439 coenzyme A binding site [chemical binding]; other site 768490013440 catalytic triad [active] 768490013441 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 768490013442 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 768490013443 tetramer interface [polypeptide binding]; other site 768490013444 active site 768490013445 Mg2+/Mn2+ binding site [ion binding]; other site 768490013446 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 768490013447 Propionate catabolism activator; Region: PrpR_N; pfam06506 768490013448 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768490013449 Walker A motif; other site 768490013450 ATP binding site [chemical binding]; other site 768490013451 Walker B motif; other site 768490013452 arginine finger; other site 768490013453 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768490013454 ornithine decarboxylase; Provisional; Region: PRK13578 768490013455 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 768490013456 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 768490013457 homodimer interface [polypeptide binding]; other site 768490013458 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490013459 catalytic residue [active] 768490013460 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 768490013461 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 768490013462 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 768490013463 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490013464 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490013465 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768490013466 dimerization interface [polypeptide binding]; other site 768490013467 Predicted transcriptional regulators [Transcription]; Region: COG1733 768490013468 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768490013469 dimerization interface [polypeptide binding]; other site 768490013470 putative DNA binding site [nucleotide binding]; other site 768490013471 putative Zn2+ binding site [ion binding]; other site 768490013472 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 768490013473 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 768490013474 classical (c) SDRs; Region: SDR_c; cd05233 768490013475 NAD(P) binding site [chemical binding]; other site 768490013476 active site 768490013477 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 768490013478 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 768490013479 Flavin Reductases; Region: FlaRed; cl00801 768490013480 This alignment model represents the N-terminal rieske domain of the oxygenase alpha subunit of aminopyrrolnitrin oxygenase (PrnD). PrnD is a novel Rieske N-oxygenase that catalyzes the final step in the pyrrolnitrin biosynthetic pathway, the oxidation...; Region: Rieske_RO_Alpha_PrnD; cd03537 768490013481 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 768490013482 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 768490013483 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 768490013484 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768490013485 Domain of unknown function (DUF1864); Region: DUF1864; pfam08933 768490013486 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 768490013487 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 768490013488 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 768490013489 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 768490013490 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 768490013491 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 768490013492 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 768490013493 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 768490013494 Walker A/P-loop; other site 768490013495 ATP binding site [chemical binding]; other site 768490013496 Q-loop/lid; other site 768490013497 ABC transporter signature motif; other site 768490013498 Walker B; other site 768490013499 D-loop; other site 768490013500 H-loop/switch region; other site 768490013501 Condensation domain; Region: Condensation; pfam00668 768490013502 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 768490013503 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 768490013504 active site 768490013505 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 768490013506 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 768490013507 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 768490013508 putative NADP binding site [chemical binding]; other site 768490013509 active site 768490013510 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768490013511 Condensation domain; Region: Condensation; pfam00668 768490013512 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 768490013513 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 768490013514 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 768490013515 acyl-activating enzyme (AAE) consensus motif; other site 768490013516 AMP binding site [chemical binding]; other site 768490013517 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768490013518 Condensation domain; Region: Condensation; pfam00668 768490013519 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 768490013520 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 768490013521 acyl-activating enzyme (AAE) consensus motif; other site 768490013522 AMP binding site [chemical binding]; other site 768490013523 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768490013524 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 768490013525 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 768490013526 acyl-activating enzyme (AAE) consensus motif; other site 768490013527 AMP binding site [chemical binding]; other site 768490013528 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768490013529 peptide synthase; Provisional; Region: PRK12467 768490013530 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 768490013531 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 768490013532 acyl-activating enzyme (AAE) consensus motif; other site 768490013533 AMP binding site [chemical binding]; other site 768490013534 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768490013535 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 768490013536 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 768490013537 acyl-activating enzyme (AAE) consensus motif; other site 768490013538 AMP binding site [chemical binding]; other site 768490013539 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768490013540 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 768490013541 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 768490013542 acyl-activating enzyme (AAE) consensus motif; other site 768490013543 AMP binding site [chemical binding]; other site 768490013544 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768490013545 C-N hydrolase family amidase; Provisional; Region: PRK10438 768490013546 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 768490013547 putative active site [active] 768490013548 catalytic triad [active] 768490013549 dimer interface [polypeptide binding]; other site 768490013550 multimer interface [polypeptide binding]; other site 768490013551 thioester reductase domain; Region: Thioester-redct; TIGR01746 768490013552 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 768490013553 putative NAD(P) binding site [chemical binding]; other site 768490013554 active site 768490013555 putative substrate binding site [chemical binding]; other site 768490013556 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 768490013557 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768490013558 NAD(P) binding site [chemical binding]; other site 768490013559 active site 768490013560 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 768490013561 FMN binding site [chemical binding]; other site 768490013562 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 768490013563 substrate binding site [chemical binding]; other site 768490013564 putative catalytic residue [active] 768490013565 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768490013566 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 768490013567 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768490013568 catalytic residue [active] 768490013569 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 768490013570 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 768490013571 active site 768490013572 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 768490013573 active site 768490013574 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 768490013575 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 768490013576 active site 2 [active] 768490013577 active site 1 [active] 768490013578 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 768490013579 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 768490013580 active site 768490013581 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 768490013582 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 768490013583 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 768490013584 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 768490013585 putative NADP binding site [chemical binding]; other site 768490013586 active site 768490013587 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 768490013588 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768490013589 FtsX-like permease family; Region: FtsX; pfam02687 768490013590 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768490013591 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768490013592 Walker A/P-loop; other site 768490013593 ATP binding site [chemical binding]; other site 768490013594 Q-loop/lid; other site 768490013595 ABC transporter signature motif; other site 768490013596 Walker B; other site 768490013597 D-loop; other site 768490013598 H-loop/switch region; other site 768490013599 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 768490013600 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 768490013601 HlyD family secretion protein; Region: HlyD_3; pfam13437 768490013602 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 768490013603 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 768490013604 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 768490013605 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 768490013606 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768490013607 catalytic residue [active] 768490013608 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 768490013609 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768490013610 PYR/PP interface [polypeptide binding]; other site 768490013611 dimer interface [polypeptide binding]; other site 768490013612 TPP binding site [chemical binding]; other site 768490013613 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768490013614 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 768490013615 TPP-binding site [chemical binding]; other site 768490013616 dimer interface [polypeptide binding]; other site 768490013617 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 768490013618 putative active site pocket [active] 768490013619 dimerization interface [polypeptide binding]; other site 768490013620 putative catalytic residue [active] 768490013621 Phosphopantetheine attachment site; Region: PP-binding; cl09936 768490013622 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 768490013623 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 768490013624 C-terminal domain interface [polypeptide binding]; other site 768490013625 GSH binding site (G-site) [chemical binding]; other site 768490013626 dimer interface [polypeptide binding]; other site 768490013627 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 768490013628 dimer interface [polypeptide binding]; other site 768490013629 N-terminal domain interface [polypeptide binding]; other site 768490013630 substrate binding pocket (H-site) [chemical binding]; other site 768490013631 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 768490013632 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 768490013633 homodimer interface [polypeptide binding]; other site 768490013634 substrate-cofactor binding pocket; other site 768490013635 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490013636 catalytic residue [active] 768490013637 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 768490013638 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 768490013639 active site pocket [active] 768490013640 Benzoate membrane transport protein; Region: BenE; pfam03594 768490013641 benzoate transporter; Region: benE; TIGR00843 768490013642 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 768490013643 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 768490013644 active site 768490013645 non-prolyl cis peptide bond; other site 768490013646 cystathionine beta-lyase; Provisional; Region: PRK05967 768490013647 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768490013648 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768490013649 catalytic residue [active] 768490013650 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 768490013651 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490013652 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490013653 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768490013654 dimerization interface [polypeptide binding]; other site 768490013655 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 768490013656 GAF domain; Region: GAF; cl17456 768490013657 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 768490013658 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768490013659 Walker A motif; other site 768490013660 ATP binding site [chemical binding]; other site 768490013661 Walker B motif; other site 768490013662 arginine finger; other site 768490013663 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 768490013664 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 768490013665 dimerization interface [polypeptide binding]; other site 768490013666 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 768490013667 ATP binding site [chemical binding]; other site 768490013668 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 768490013669 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 768490013670 HupF/HypC family; Region: HupF_HypC; cl00394 768490013671 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 768490013672 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 768490013673 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 768490013674 Transcriptional repressor of hyc and hyp operons; Region: HycA_repressor; cl08095 768490013675 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 768490013676 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 768490013677 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 768490013678 NADH dehydrogenase; Region: NADHdh; cl00469 768490013679 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 768490013680 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 768490013681 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 768490013682 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 768490013683 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768490013684 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 768490013685 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 768490013686 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 768490013687 nickel binding site [ion binding]; other site 768490013688 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 768490013689 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 768490013690 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 768490013691 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 768490013692 [4Fe-4S] binding site [ion binding]; other site 768490013693 molybdopterin cofactor binding site; other site 768490013694 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 768490013695 molybdopterin cofactor binding site; other site 768490013696 Acylphosphatase; Region: Acylphosphatase; pfam00708 768490013697 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 768490013698 HypF finger; Region: zf-HYPF; pfam07503 768490013699 HypF finger; Region: zf-HYPF; pfam07503 768490013700 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 768490013701 High-affinity nickel-transport protein; Region: NicO; cl00964 768490013702 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490013703 Coenzyme A binding pocket [chemical binding]; other site 768490013704 PAS fold; Region: PAS_4; pfam08448 768490013705 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768490013706 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768490013707 DNA binding residues [nucleotide binding] 768490013708 dimerization interface [polypeptide binding]; other site 768490013709 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 768490013710 Na binding site [ion binding]; other site 768490013711 NIPSNAP; Region: NIPSNAP; pfam07978 768490013712 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768490013713 non-specific DNA binding site [nucleotide binding]; other site 768490013714 salt bridge; other site 768490013715 sequence-specific DNA binding site [nucleotide binding]; other site 768490013716 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 768490013717 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 768490013718 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 768490013719 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 768490013720 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 768490013721 Phosphoesterase family; Region: Phosphoesterase; pfam04185 768490013722 Domain of unknown function (DUF756); Region: DUF756; pfam05506 768490013723 Domain of unknown function (DUF756); Region: DUF756; pfam05506 768490013724 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 768490013725 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768490013726 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768490013727 salt bridge; other site 768490013728 non-specific DNA binding site [nucleotide binding]; other site 768490013729 sequence-specific DNA binding site [nucleotide binding]; other site 768490013730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490013731 putative substrate translocation pore; other site 768490013732 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 768490013733 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 768490013734 Protein of unknown function, DUF596; Region: DUF596; cl10492 768490013735 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768490013736 anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154 768490013737 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 768490013738 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 768490013739 haemagglutination activity domain; Region: Haemagg_act; pfam05860 768490013740 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 768490013741 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768490013742 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768490013743 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768490013744 RTX toxin acyltransferase family; Region: HlyC; pfam02794 768490013745 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 768490013746 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 768490013747 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 768490013748 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768490013749 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 768490013750 putative substrate binding site [chemical binding]; other site 768490013751 putative ATP binding site [chemical binding]; other site 768490013752 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768490013753 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 768490013754 active site turn [active] 768490013755 phosphorylation site [posttranslational modification] 768490013756 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768490013757 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 768490013758 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 768490013759 substrate binding [chemical binding]; other site 768490013760 active site 768490013761 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 768490013762 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 768490013763 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768490013764 DNA binding site [nucleotide binding] 768490013765 domain linker motif; other site 768490013766 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 768490013767 dimerization interface [polypeptide binding]; other site 768490013768 ligand binding site [chemical binding]; other site 768490013769 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 768490013770 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 768490013771 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 768490013772 shikimate binding site; other site 768490013773 NAD(P) binding site [chemical binding]; other site 768490013774 biopolymer transport protein ExbD; Provisional; Region: PRK11267 768490013775 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 768490013776 biopolymer transport protein ExbB; Provisional; Region: PRK10414 768490013777 cystathionine beta-lyase; Provisional; Region: PRK08114 768490013778 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 768490013779 homodimer interface [polypeptide binding]; other site 768490013780 substrate-cofactor binding pocket; other site 768490013781 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490013782 catalytic residue [active] 768490013783 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 768490013784 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 768490013785 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490013786 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490013787 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 768490013788 putative effector binding pocket; other site 768490013789 putative dimerization interface [polypeptide binding]; other site 768490013790 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 768490013791 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 768490013792 putative NAD(P) binding site [chemical binding]; other site 768490013793 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 768490013794 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768490013795 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490013796 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490013797 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 768490013798 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 768490013799 dimer interface [polypeptide binding]; other site 768490013800 active site 768490013801 metal binding site [ion binding]; metal-binding site 768490013802 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768490013803 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768490013804 active site 768490013805 catalytic tetrad [active] 768490013806 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 768490013807 beta-galactosidase; Region: BGL; TIGR03356 768490013808 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 768490013809 methionine cluster; other site 768490013810 active site 768490013811 phosphorylation site [posttranslational modification] 768490013812 metal binding site [ion binding]; metal-binding site 768490013813 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 768490013814 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 768490013815 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 768490013816 active site 768490013817 P-loop; other site 768490013818 phosphorylation site [posttranslational modification] 768490013819 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 768490013820 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768490013821 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768490013822 catalytic residue [active] 768490013823 hypothetical protein; Provisional; Region: PRK01254 768490013824 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 768490013825 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 768490013826 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 768490013827 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768490013828 substrate binding site [chemical binding]; other site 768490013829 ATP binding site [chemical binding]; other site 768490013830 nucleoside transporter; Region: 2A0110; TIGR00889 768490013831 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490013832 purine nucleoside phosphorylase; Provisional; Region: PRK08202 768490013833 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 768490013834 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490013835 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 768490013836 putative dimerization interface [polypeptide binding]; other site 768490013837 putative substrate binding pocket [chemical binding]; other site 768490013838 FtsI repressor; Provisional; Region: PRK10883 768490013839 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 768490013840 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 768490013841 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 768490013842 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 768490013843 putative acyl-acceptor binding pocket; other site 768490013844 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 768490013845 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 768490013846 CAP-like domain; other site 768490013847 active site 768490013848 primary dimer interface [polypeptide binding]; other site 768490013849 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 768490013850 Uncharacterized conserved protein [Function unknown]; Region: COG1359 768490013851 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490013852 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490013853 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768490013854 dimerization interface [polypeptide binding]; other site 768490013855 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 768490013856 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490013857 ATP binding site [chemical binding]; other site 768490013858 Mg2+ binding site [ion binding]; other site 768490013859 G-X-G motif; other site 768490013860 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 768490013861 anchoring element; other site 768490013862 dimer interface [polypeptide binding]; other site 768490013863 ATP binding site [chemical binding]; other site 768490013864 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 768490013865 active site 768490013866 metal binding site [ion binding]; metal-binding site 768490013867 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 768490013868 esterase YqiA; Provisional; Region: PRK11071 768490013869 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768490013870 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 768490013871 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 768490013872 active site 768490013873 metal binding site [ion binding]; metal-binding site 768490013874 hexamer interface [polypeptide binding]; other site 768490013875 putative dehydrogenase; Provisional; Region: PRK11039 768490013876 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 768490013877 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 768490013878 dimer interface [polypeptide binding]; other site 768490013879 ADP-ribose binding site [chemical binding]; other site 768490013880 active site 768490013881 nudix motif; other site 768490013882 metal binding site [ion binding]; metal-binding site 768490013883 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 768490013884 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 768490013885 GAF domain; Region: GAF; pfam01590 768490013886 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 768490013887 putative active site [active] 768490013888 heme pocket [chemical binding]; other site 768490013889 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768490013890 Walker A motif; other site 768490013891 ATP binding site [chemical binding]; other site 768490013892 Walker B motif; other site 768490013893 arginine finger; other site 768490013894 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768490013895 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 768490013896 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 768490013897 active pocket/dimerization site; other site 768490013898 active site 768490013899 phosphorylation site [posttranslational modification] 768490013900 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 768490013901 dimerization domain swap beta strand [polypeptide binding]; other site 768490013902 regulatory protein interface [polypeptide binding]; other site 768490013903 active site 768490013904 regulatory phosphorylation site [posttranslational modification]; other site 768490013905 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 768490013906 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 768490013907 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 768490013908 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 768490013909 Dak1 domain; Region: Dak1; pfam02733 768490013910 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 768490013911 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 768490013912 dimer interface [polypeptide binding]; other site 768490013913 active site 768490013914 metal binding site [ion binding]; metal-binding site 768490013915 hypothetical protein; Provisional; Region: PRK11653 768490013916 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 768490013917 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 768490013918 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 768490013919 putative active site [active] 768490013920 metal binding site [ion binding]; metal-binding site 768490013921 zinc transporter ZupT; Provisional; Region: PRK04201 768490013922 ZIP Zinc transporter; Region: Zip; pfam02535 768490013923 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 768490013924 dimer interface [polypeptide binding]; other site 768490013925 Alkaline phosphatase homologues; Region: alkPPc; smart00098 768490013926 active site 768490013927 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 768490013928 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 768490013929 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 768490013930 putative transporter; Provisional; Region: PRK11021 768490013931 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 768490013932 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 768490013933 putative ribose interaction site [chemical binding]; other site 768490013934 putative ADP binding site [chemical binding]; other site 768490013935 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 768490013936 active site 768490013937 nucleotide binding site [chemical binding]; other site 768490013938 HIGH motif; other site 768490013939 KMSKS motif; other site 768490013940 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 768490013941 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 768490013942 metal binding triad; other site 768490013943 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 768490013944 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 768490013945 metal binding triad; other site 768490013946 Uncharacterized conserved protein [Function unknown]; Region: COG3025 768490013947 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 768490013948 putative active site [active] 768490013949 putative metal binding residues [ion binding]; other site 768490013950 signature motif; other site 768490013951 putative triphosphate binding site [ion binding]; other site 768490013952 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 768490013953 SH3 domain-containing protein; Provisional; Region: PRK10884 768490013954 Bacterial SH3 domain homologues; Region: SH3b; smart00287 768490013955 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 768490013956 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 768490013957 active site 768490013958 NTP binding site [chemical binding]; other site 768490013959 metal binding triad [ion binding]; metal-binding site 768490013960 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 768490013961 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768490013962 Zn2+ binding site [ion binding]; other site 768490013963 Mg2+ binding site [ion binding]; other site 768490013964 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 768490013965 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 768490013966 homooctamer interface [polypeptide binding]; other site 768490013967 active site 768490013968 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 768490013969 UGMP family protein; Validated; Region: PRK09604 768490013970 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 768490013971 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 768490013972 DNA primase; Validated; Region: dnaG; PRK05667 768490013973 CHC2 zinc finger; Region: zf-CHC2; pfam01807 768490013974 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 768490013975 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 768490013976 active site 768490013977 metal binding site [ion binding]; metal-binding site 768490013978 interdomain interaction site; other site 768490013979 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 768490013980 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 768490013981 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 768490013982 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 768490013983 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 768490013984 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 768490013985 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768490013986 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 768490013987 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768490013988 DNA binding residues [nucleotide binding] 768490013989 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 768490013990 active site 768490013991 SUMO-1 interface [polypeptide binding]; other site 768490013992 HPP family; Region: HPP; pfam04982 768490013993 glutathione S-transferase; Provisional; Region: PRK15113 768490013994 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 768490013995 C-terminal domain interface [polypeptide binding]; other site 768490013996 GSH binding site (G-site) [chemical binding]; other site 768490013997 dimer interface [polypeptide binding]; other site 768490013998 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 768490013999 N-terminal domain interface [polypeptide binding]; other site 768490014000 putative dimer interface [polypeptide binding]; other site 768490014001 putative substrate binding pocket (H-site) [chemical binding]; other site 768490014002 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 768490014003 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 768490014004 succinic semialdehyde dehydrogenase; Region: PLN02278 768490014005 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 768490014006 tetramerization interface [polypeptide binding]; other site 768490014007 NAD(P) binding site [chemical binding]; other site 768490014008 catalytic residues [active] 768490014009 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 768490014010 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768490014011 inhibitor-cofactor binding pocket; inhibition site 768490014012 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490014013 catalytic residue [active] 768490014014 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768490014015 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768490014016 DNA-binding site [nucleotide binding]; DNA binding site 768490014017 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768490014018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490014019 homodimer interface [polypeptide binding]; other site 768490014020 catalytic residue [active] 768490014021 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 768490014022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768490014023 Walker A/P-loop; other site 768490014024 ATP binding site [chemical binding]; other site 768490014025 Q-loop/lid; other site 768490014026 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768490014027 ABC transporter signature motif; other site 768490014028 Walker B; other site 768490014029 D-loop; other site 768490014030 ABC transporter; Region: ABC_tran_2; pfam12848 768490014031 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768490014032 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 768490014033 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 768490014034 active site 768490014035 FMN binding site [chemical binding]; other site 768490014036 2,4-decadienoyl-CoA binding site; other site 768490014037 catalytic residue [active] 768490014038 4Fe-4S cluster binding site [ion binding]; other site 768490014039 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 768490014040 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768490014041 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 768490014042 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490014043 S-adenosylmethionine binding site [chemical binding]; other site 768490014044 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 768490014045 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768490014046 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768490014047 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 768490014048 catalytic triad [active] 768490014049 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 768490014050 serine/threonine transporter SstT; Provisional; Region: PRK13628 768490014051 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 768490014052 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 768490014053 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 768490014054 galactarate dehydratase; Region: galactar-dH20; TIGR03248 768490014055 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 768490014056 Glucuronate isomerase; Region: UxaC; pfam02614 768490014057 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 768490014058 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490014059 D-galactonate transporter; Region: 2A0114; TIGR00893 768490014060 putative substrate translocation pore; other site 768490014061 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 768490014062 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768490014063 DNA-binding site [nucleotide binding]; DNA binding site 768490014064 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 768490014065 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 768490014066 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 768490014067 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 768490014068 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 768490014069 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 768490014070 Predicted membrane protein [Function unknown]; Region: COG5393 768490014071 YqjK-like protein; Region: YqjK; pfam13997 768490014072 Predicted membrane protein [Function unknown]; Region: COG2259 768490014073 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 768490014074 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 768490014075 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 768490014076 putative dimer interface [polypeptide binding]; other site 768490014077 N-terminal domain interface [polypeptide binding]; other site 768490014078 putative substrate binding pocket (H-site) [chemical binding]; other site 768490014079 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490014080 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 768490014081 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768490014082 dimerization interface [polypeptide binding]; other site 768490014083 Pirin-related protein [General function prediction only]; Region: COG1741 768490014084 Pirin; Region: Pirin; pfam02678 768490014085 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 768490014086 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 768490014087 putative SAM binding site [chemical binding]; other site 768490014088 putative homodimer interface [polypeptide binding]; other site 768490014089 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 768490014090 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 768490014091 putative ligand binding site [chemical binding]; other site 768490014092 hypothetical protein; Reviewed; Region: PRK12497 768490014093 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 768490014094 dimer interface [polypeptide binding]; other site 768490014095 active site 768490014096 outer membrane lipoprotein; Provisional; Region: PRK11023 768490014097 bacterial OsmY and nodulation domain; Region: BON; smart00749 768490014098 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 768490014099 Transglycosylase; Region: Transgly; cl17702 768490014100 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 768490014101 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 768490014102 conserved cys residue [active] 768490014103 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 768490014104 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768490014105 putative active site [active] 768490014106 heme pocket [chemical binding]; other site 768490014107 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768490014108 dimer interface [polypeptide binding]; other site 768490014109 phosphorylation site [posttranslational modification] 768490014110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490014111 ATP binding site [chemical binding]; other site 768490014112 Mg2+ binding site [ion binding]; other site 768490014113 G-X-G motif; other site 768490014114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490014115 active site 768490014116 phosphorylation site [posttranslational modification] 768490014117 intermolecular recognition site; other site 768490014118 dimerization interface [polypeptide binding]; other site 768490014119 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 768490014120 putative binding surface; other site 768490014121 active site 768490014122 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 768490014123 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768490014124 FeS/SAM binding site; other site 768490014125 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 768490014126 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 768490014127 active site 768490014128 dimer interface [polypeptide binding]; other site 768490014129 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 768490014130 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 768490014131 active site 768490014132 FMN binding site [chemical binding]; other site 768490014133 substrate binding site [chemical binding]; other site 768490014134 3Fe-4S cluster binding site [ion binding]; other site 768490014135 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 768490014136 domain interface; other site 768490014137 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 768490014138 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768490014139 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 768490014140 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768490014141 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 768490014142 stringent starvation protein A; Provisional; Region: sspA; PRK09481 768490014143 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 768490014144 C-terminal domain interface [polypeptide binding]; other site 768490014145 putative GSH binding site (G-site) [chemical binding]; other site 768490014146 dimer interface [polypeptide binding]; other site 768490014147 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 768490014148 dimer interface [polypeptide binding]; other site 768490014149 N-terminal domain interface [polypeptide binding]; other site 768490014150 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 768490014151 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 768490014152 23S rRNA interface [nucleotide binding]; other site 768490014153 L3 interface [polypeptide binding]; other site 768490014154 Predicted ATPase [General function prediction only]; Region: COG1485 768490014155 hypothetical protein; Provisional; Region: PRK11677 768490014156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 768490014157 serine endoprotease; Provisional; Region: PRK10139 768490014158 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 768490014159 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 768490014160 protein binding site [polypeptide binding]; other site 768490014161 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 768490014162 serine endoprotease; Provisional; Region: PRK10898 768490014163 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 768490014164 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 768490014165 protein binding site [polypeptide binding]; other site 768490014166 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 768490014167 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 768490014168 hinge; other site 768490014169 active site 768490014170 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 768490014171 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 768490014172 anti sigma factor interaction site; other site 768490014173 regulatory phosphorylation site [posttranslational modification]; other site 768490014174 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 768490014175 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 768490014176 mce related protein; Region: MCE; pfam02470 768490014177 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 768490014178 conserved hypothetical integral membrane protein; Region: TIGR00056 768490014179 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 768490014180 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 768490014181 Walker A/P-loop; other site 768490014182 ATP binding site [chemical binding]; other site 768490014183 Q-loop/lid; other site 768490014184 ABC transporter signature motif; other site 768490014185 Walker B; other site 768490014186 D-loop; other site 768490014187 H-loop/switch region; other site 768490014188 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 768490014189 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 768490014190 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 768490014191 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 768490014192 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 768490014193 putative active site [active] 768490014194 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 768490014195 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 768490014196 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 768490014197 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 768490014198 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 768490014199 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 768490014200 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 768490014201 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 768490014202 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 768490014203 Walker A/P-loop; other site 768490014204 ATP binding site [chemical binding]; other site 768490014205 Q-loop/lid; other site 768490014206 ABC transporter signature motif; other site 768490014207 Walker B; other site 768490014208 D-loop; other site 768490014209 H-loop/switch region; other site 768490014210 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 768490014211 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 768490014212 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 768490014213 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 768490014214 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 768490014215 30S subunit binding site; other site 768490014216 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 768490014217 active site 768490014218 phosphorylation site [posttranslational modification] 768490014219 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 768490014220 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 768490014221 dimerization domain swap beta strand [polypeptide binding]; other site 768490014222 regulatory protein interface [polypeptide binding]; other site 768490014223 active site 768490014224 regulatory phosphorylation site [posttranslational modification]; other site 768490014225 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 768490014226 HTH domain; Region: HTH_11; pfam08279 768490014227 Mga helix-turn-helix domain; Region: Mga; pfam05043 768490014228 PRD domain; Region: PRD; pfam00874 768490014229 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 768490014230 active site 768490014231 P-loop; other site 768490014232 phosphorylation site [posttranslational modification] 768490014233 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 768490014234 active site 768490014235 phosphorylation site [posttranslational modification] 768490014236 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 768490014237 Protein of unknown function (DUF1341); Region: DUF1341; pfam07071 768490014238 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 768490014239 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768490014240 catalytic residue [active] 768490014241 dihydroorotase; Provisional; Region: PRK09237 768490014242 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 768490014243 active site 768490014244 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 768490014245 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 768490014246 Domain of unknown function (DUF4312); Region: DUF4312; pfam14189 768490014247 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272 768490014248 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 768490014249 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 768490014250 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 768490014251 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 768490014252 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 768490014253 active site 768490014254 cosubstrate binding site; other site 768490014255 substrate binding site [chemical binding]; other site 768490014256 catalytic site [active] 768490014257 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 768490014258 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 768490014259 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768490014260 Helix-turn-helix domain; Region: HTH_18; pfam12833 768490014261 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490014262 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490014263 Cytochrome b562; Region: Cytochrom_B562; cl01546 768490014264 peptidase PmbA; Provisional; Region: PRK11040 768490014265 hypothetical protein; Provisional; Region: PRK05255 768490014266 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 768490014267 RNAase interaction site [polypeptide binding]; other site 768490014268 Barnase, a member of the family of homologous microbial ribonucleases, catalyses the cleavage of single-stranded RNA via a two-step mechanism thought to be similar to that of pancreatic ribonuclease. The mechanism involves a transesterification to give a...; Region: barnase; cd00933 768490014269 active site 768490014270 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 768490014271 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 768490014272 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 768490014273 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768490014274 HlyD family secretion protein; Region: HlyD_3; pfam13437 768490014275 efflux system membrane protein; Provisional; Region: PRK11594 768490014276 transcriptional regulator; Provisional; Region: PRK10632 768490014277 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490014278 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768490014279 putative effector binding pocket; other site 768490014280 dimerization interface [polypeptide binding]; other site 768490014281 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 768490014282 active site 768490014283 tetramer interface [polypeptide binding]; other site 768490014284 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 768490014285 haemagglutination activity domain; Region: Haemagg_act; pfam05860 768490014286 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768490014287 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768490014288 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768490014289 MafB19-like deaminase; Region: MafB19-deam; pfam14437 768490014290 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 768490014291 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 768490014292 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 768490014293 protease TldD; Provisional; Region: tldD; PRK10735 768490014294 nitrilase; Region: PLN02798 768490014295 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 768490014296 putative active site [active] 768490014297 catalytic triad [active] 768490014298 dimer interface [polypeptide binding]; other site 768490014299 hypothetical protein; Provisional; Region: PRK10899 768490014300 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 768490014301 ribonuclease G; Provisional; Region: PRK11712 768490014302 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 768490014303 homodimer interface [polypeptide binding]; other site 768490014304 oligonucleotide binding site [chemical binding]; other site 768490014305 Maf-like protein; Region: Maf; pfam02545 768490014306 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 768490014307 active site 768490014308 dimer interface [polypeptide binding]; other site 768490014309 rod shape-determining protein MreD; Provisional; Region: PRK11060 768490014310 rod shape-determining protein MreC; Region: mreC; TIGR00219 768490014311 rod shape-determining protein MreC; Region: MreC; pfam04085 768490014312 rod shape-determining protein MreB; Provisional; Region: PRK13927 768490014313 MreB and similar proteins; Region: MreB_like; cd10225 768490014314 nucleotide binding site [chemical binding]; other site 768490014315 Mg binding site [ion binding]; other site 768490014316 putative protofilament interaction site [polypeptide binding]; other site 768490014317 RodZ interaction site [polypeptide binding]; other site 768490014318 regulatory protein CsrD; Provisional; Region: PRK11059 768490014319 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768490014320 metal binding site [ion binding]; metal-binding site 768490014321 active site 768490014322 I-site; other site 768490014323 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768490014324 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 768490014325 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 768490014326 NADP binding site [chemical binding]; other site 768490014327 dimer interface [polypeptide binding]; other site 768490014328 TMAO/DMSO reductase; Reviewed; Region: PRK05363 768490014329 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 768490014330 Moco binding site; other site 768490014331 metal coordination site [ion binding]; other site 768490014332 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 768490014333 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 768490014334 Dehydroquinase class II; Region: DHquinase_II; pfam01220 768490014335 active site 768490014336 trimer interface [polypeptide binding]; other site 768490014337 dimer interface [polypeptide binding]; other site 768490014338 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 768490014339 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 768490014340 carboxyltransferase (CT) interaction site; other site 768490014341 biotinylation site [posttranslational modification]; other site 768490014342 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 768490014343 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 768490014344 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 768490014345 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 768490014346 hypothetical protein; Provisional; Region: PRK10633 768490014347 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 768490014348 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 768490014349 Na binding site [ion binding]; other site 768490014350 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 768490014351 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 768490014352 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 768490014353 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 768490014354 active site 768490014355 zinc binding site [ion binding]; other site 768490014356 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 768490014357 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 768490014358 FMN binding site [chemical binding]; other site 768490014359 active site 768490014360 catalytic residues [active] 768490014361 substrate binding site [chemical binding]; other site 768490014362 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 768490014363 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 768490014364 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 768490014365 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 768490014366 putative acyl-acceptor binding pocket; other site 768490014367 hypothetical protein; Validated; Region: PRK06186 768490014368 conserved cys residue [active] 768490014369 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 768490014370 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 768490014371 acyl-activating enzyme (AAE) consensus motif; other site 768490014372 AMP binding site [chemical binding]; other site 768490014373 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768490014374 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 768490014375 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 768490014376 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490014377 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490014378 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 768490014379 putative dimerization interface [polypeptide binding]; other site 768490014380 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 768490014381 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 768490014382 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 768490014383 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768490014384 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 768490014385 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 768490014386 putative C-terminal domain interface [polypeptide binding]; other site 768490014387 putative GSH binding site (G-site) [chemical binding]; other site 768490014388 putative dimer interface [polypeptide binding]; other site 768490014389 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 768490014390 putative N-terminal domain interface [polypeptide binding]; other site 768490014391 putative dimer interface [polypeptide binding]; other site 768490014392 putative substrate binding pocket (H-site) [chemical binding]; other site 768490014393 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 768490014394 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490014395 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490014396 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768490014397 putative effector binding pocket; other site 768490014398 dimerization interface [polypeptide binding]; other site 768490014399 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 768490014400 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768490014401 NAD(P) binding site [chemical binding]; other site 768490014402 active site 768490014403 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 768490014404 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 768490014405 dimer interface [polypeptide binding]; other site 768490014406 ssDNA binding site [nucleotide binding]; other site 768490014407 tetramer (dimer of dimers) interface [polypeptide binding]; other site 768490014408 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 768490014409 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 768490014410 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 768490014411 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 768490014412 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 768490014413 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 768490014414 putative NAD(P) binding site [chemical binding]; other site 768490014415 putative substrate binding site [chemical binding]; other site 768490014416 catalytic Zn binding site [ion binding]; other site 768490014417 structural Zn binding site [ion binding]; other site 768490014418 dimer interface [polypeptide binding]; other site 768490014419 maltose O-acetyltransferase; Provisional; Region: PRK10092 768490014420 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 768490014421 active site 768490014422 substrate binding site [chemical binding]; other site 768490014423 trimer interface [polypeptide binding]; other site 768490014424 CoA binding site [chemical binding]; other site 768490014425 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 768490014426 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 768490014427 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 768490014428 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768490014429 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490014430 homodimer interface [polypeptide binding]; other site 768490014431 catalytic residue [active] 768490014432 Uncharacterized conserved protein [Function unknown]; Region: COG1284 768490014433 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 768490014434 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768490014435 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 768490014436 putative DNA binding site [nucleotide binding]; other site 768490014437 putative Zn2+ binding site [ion binding]; other site 768490014438 AsnC family; Region: AsnC_trans_reg; pfam01037 768490014439 aromatic amino acid transporter; Provisional; Region: PRK10238 768490014440 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768490014441 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768490014442 substrate binding pocket [chemical binding]; other site 768490014443 membrane-bound complex binding site; other site 768490014444 hinge residues; other site 768490014445 alanine racemase; Reviewed; Region: alr; PRK00053 768490014446 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 768490014447 active site 768490014448 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768490014449 substrate binding site [chemical binding]; other site 768490014450 catalytic residues [active] 768490014451 dimer interface [polypeptide binding]; other site 768490014452 replicative DNA helicase; Provisional; Region: PRK08006 768490014453 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 768490014454 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 768490014455 Walker A motif; other site 768490014456 ATP binding site [chemical binding]; other site 768490014457 Walker B motif; other site 768490014458 DNA binding loops [nucleotide binding] 768490014459 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 768490014460 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 768490014461 NADP binding site [chemical binding]; other site 768490014462 dimer interface [polypeptide binding]; other site 768490014463 phage shock protein G; Reviewed; Region: pspG; PRK09459 768490014464 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 768490014465 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 768490014466 FMN binding site [chemical binding]; other site 768490014467 active site 768490014468 catalytic residues [active] 768490014469 substrate binding site [chemical binding]; other site 768490014470 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768490014471 binding surface 768490014472 TPR motif; other site 768490014473 Tetratricopeptide repeat; Region: TPR_16; pfam13432 768490014474 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 768490014475 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768490014476 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768490014477 DNA binding residues [nucleotide binding] 768490014478 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 768490014479 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 768490014480 metal binding site 2 [ion binding]; metal-binding site 768490014481 putative DNA binding helix; other site 768490014482 metal binding site 1 [ion binding]; metal-binding site 768490014483 dimer interface [polypeptide binding]; other site 768490014484 structural Zn2+ binding site [ion binding]; other site 768490014485 hypothetical protein; Provisional; Region: PRK10428 768490014486 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 768490014487 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 768490014488 LexA repressor; Validated; Region: PRK00215 768490014489 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 768490014490 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 768490014491 Catalytic site [active] 768490014492 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 768490014493 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 768490014494 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 768490014495 putative acyl-acceptor binding pocket; other site 768490014496 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 768490014497 UbiA prenyltransferase family; Region: UbiA; pfam01040 768490014498 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 768490014499 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 768490014500 active site 768490014501 maltose regulon periplasmic protein; Provisional; Region: PRK10564 768490014502 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 768490014503 trimer interface; other site 768490014504 sugar binding site [chemical binding]; other site 768490014505 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 768490014506 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 768490014507 Walker A/P-loop; other site 768490014508 ATP binding site [chemical binding]; other site 768490014509 Q-loop/lid; other site 768490014510 ABC transporter signature motif; other site 768490014511 Walker B; other site 768490014512 D-loop; other site 768490014513 H-loop/switch region; other site 768490014514 TOBE domain; Region: TOBE_2; pfam08402 768490014515 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 768490014516 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 768490014517 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 768490014518 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490014519 dimer interface [polypeptide binding]; other site 768490014520 conserved gate region; other site 768490014521 putative PBP binding loops; other site 768490014522 ABC-ATPase subunit interface; other site 768490014523 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 768490014524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490014525 dimer interface [polypeptide binding]; other site 768490014526 conserved gate region; other site 768490014527 putative PBP binding loops; other site 768490014528 ABC-ATPase subunit interface; other site 768490014529 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 768490014530 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 768490014531 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 768490014532 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 768490014533 active site 768490014534 dimer interface [polypeptide binding]; other site 768490014535 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 768490014536 dimer interface [polypeptide binding]; other site 768490014537 active site 768490014538 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 768490014539 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 768490014540 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 768490014541 TrkA-N domain; Region: TrkA_N; pfam02254 768490014542 aspartate kinase III; Validated; Region: PRK09084 768490014543 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 768490014544 nucleotide binding site [chemical binding]; other site 768490014545 substrate binding site [chemical binding]; other site 768490014546 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 768490014547 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 768490014548 dimer interface [polypeptide binding]; other site 768490014549 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 768490014550 Sodium Bile acid symporter family; Region: SBF; pfam01758 768490014551 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 768490014552 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 768490014553 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 768490014554 haemagglutination activity domain; Region: Haemagg_act; pfam05860 768490014555 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768490014556 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768490014557 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768490014558 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768490014559 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768490014560 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 768490014561 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 768490014562 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 768490014563 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768490014564 Walker A/P-loop; other site 768490014565 ATP binding site [chemical binding]; other site 768490014566 Q-loop/lid; other site 768490014567 ABC transporter signature motif; other site 768490014568 Walker B; other site 768490014569 D-loop; other site 768490014570 H-loop/switch region; other site 768490014571 TOBE domain; Region: TOBE_2; pfam08402 768490014572 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 768490014573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490014574 dimer interface [polypeptide binding]; other site 768490014575 conserved gate region; other site 768490014576 putative PBP binding loops; other site 768490014577 ABC-ATPase subunit interface; other site 768490014578 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 768490014579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490014580 putative PBP binding loops; other site 768490014581 ABC-ATPase subunit interface; other site 768490014582 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 768490014583 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 768490014584 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 768490014585 transcriptional regulator protein; Region: phnR; TIGR03337 768490014586 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768490014587 DNA-binding site [nucleotide binding]; DNA binding site 768490014588 UTRA domain; Region: UTRA; pfam07702 768490014589 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 768490014590 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 768490014591 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 768490014592 substrate binding pocket [chemical binding]; other site 768490014593 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 768490014594 B12 binding site [chemical binding]; other site 768490014595 cobalt ligand [ion binding]; other site 768490014596 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 768490014597 transcriptional repressor IclR; Provisional; Region: PRK11569 768490014598 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 768490014599 Bacterial transcriptional regulator; Region: IclR; pfam01614 768490014600 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 768490014601 ATP-binding site [chemical binding]; other site 768490014602 Gluconate-6-phosphate binding site [chemical binding]; other site 768490014603 low affinity gluconate transporter; Provisional; Region: PRK10472 768490014604 GntP family permease; Region: GntP_permease; pfam02447 768490014605 phosphogluconate dehydratase; Validated; Region: PRK09054 768490014606 6-phosphogluconate dehydratase; Region: edd; TIGR01196 768490014607 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 768490014608 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 768490014609 active site 768490014610 intersubunit interface [polypeptide binding]; other site 768490014611 catalytic residue [active] 768490014612 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 768490014613 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 768490014614 isocitrate lyase; Provisional; Region: PRK15063 768490014615 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 768490014616 tetramer interface [polypeptide binding]; other site 768490014617 active site 768490014618 Mg2+/Mn2+ binding site [ion binding]; other site 768490014619 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 768490014620 malate synthase A; Region: malate_syn_A; TIGR01344 768490014621 active site 768490014622 homoserine O-succinyltransferase; Provisional; Region: PRK05368 768490014623 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 768490014624 proposed active site lysine [active] 768490014625 conserved cys residue [active] 768490014626 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 768490014627 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 768490014628 trimer interface [polypeptide binding]; other site 768490014629 putative metal binding site [ion binding]; other site 768490014630 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 768490014631 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 768490014632 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 768490014633 shikimate binding site; other site 768490014634 NAD(P) binding site [chemical binding]; other site 768490014635 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 768490014636 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 768490014637 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 768490014638 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 768490014639 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 768490014640 hypothetical protein; Validated; Region: PRK03430 768490014641 hypothetical protein; Provisional; Region: PRK10736 768490014642 DNA protecting protein DprA; Region: dprA; TIGR00732 768490014643 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 768490014644 active site 768490014645 catalytic residues [active] 768490014646 metal binding site [ion binding]; metal-binding site 768490014647 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 768490014648 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 768490014649 putative active site [active] 768490014650 substrate binding site [chemical binding]; other site 768490014651 putative cosubstrate binding site; other site 768490014652 catalytic site [active] 768490014653 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 768490014654 substrate binding site [chemical binding]; other site 768490014655 16S rRNA methyltransferase B; Provisional; Region: PRK10901 768490014656 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 768490014657 putative RNA binding site [nucleotide binding]; other site 768490014658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490014659 S-adenosylmethionine binding site [chemical binding]; other site 768490014660 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 768490014661 TrkA-N domain; Region: TrkA_N; pfam02254 768490014662 TrkA-C domain; Region: TrkA_C; pfam02080 768490014663 TrkA-N domain; Region: TrkA_N; pfam02254 768490014664 TrkA-C domain; Region: TrkA_C; pfam02080 768490014665 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 768490014666 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 768490014667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 768490014668 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 768490014669 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 768490014670 DNA binding residues [nucleotide binding] 768490014671 dimer interface [polypeptide binding]; other site 768490014672 metal binding site [ion binding]; metal-binding site 768490014673 hypothetical protein; Provisional; Region: PRK10203 768490014674 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 768490014675 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 768490014676 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 768490014677 alphaNTD homodimer interface [polypeptide binding]; other site 768490014678 alphaNTD - beta interaction site [polypeptide binding]; other site 768490014679 alphaNTD - beta' interaction site [polypeptide binding]; other site 768490014680 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 768490014681 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 768490014682 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 768490014683 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768490014684 RNA binding surface [nucleotide binding]; other site 768490014685 30S ribosomal protein S11; Validated; Region: PRK05309 768490014686 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 768490014687 30S ribosomal protein S13; Region: bact_S13; TIGR03631 768490014688 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 768490014689 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 768490014690 SecY translocase; Region: SecY; pfam00344 768490014691 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 768490014692 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 768490014693 23S rRNA binding site [nucleotide binding]; other site 768490014694 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 768490014695 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 768490014696 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 768490014697 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 768490014698 5S rRNA interface [nucleotide binding]; other site 768490014699 23S rRNA interface [nucleotide binding]; other site 768490014700 L5 interface [polypeptide binding]; other site 768490014701 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 768490014702 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 768490014703 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 768490014704 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 768490014705 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 768490014706 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 768490014707 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 768490014708 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 768490014709 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 768490014710 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 768490014711 RNA binding site [nucleotide binding]; other site 768490014712 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 768490014713 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 768490014714 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 768490014715 23S rRNA interface [nucleotide binding]; other site 768490014716 putative translocon interaction site; other site 768490014717 signal recognition particle (SRP54) interaction site; other site 768490014718 L23 interface [polypeptide binding]; other site 768490014719 trigger factor interaction site; other site 768490014720 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 768490014721 23S rRNA interface [nucleotide binding]; other site 768490014722 5S rRNA interface [nucleotide binding]; other site 768490014723 putative antibiotic binding site [chemical binding]; other site 768490014724 L25 interface [polypeptide binding]; other site 768490014725 L27 interface [polypeptide binding]; other site 768490014726 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 768490014727 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 768490014728 G-X-X-G motif; other site 768490014729 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 768490014730 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 768490014731 protein-rRNA interface [nucleotide binding]; other site 768490014732 putative translocon binding site; other site 768490014733 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 768490014734 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 768490014735 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 768490014736 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 768490014737 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 768490014738 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 768490014739 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 768490014740 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 768490014741 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 768490014742 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 768490014743 heme binding site [chemical binding]; other site 768490014744 ferroxidase pore; other site 768490014745 ferroxidase diiron center [ion binding]; other site 768490014746 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 768490014747 elongation factor Tu; Reviewed; Region: PRK00049 768490014748 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 768490014749 G1 box; other site 768490014750 GEF interaction site [polypeptide binding]; other site 768490014751 GTP/Mg2+ binding site [chemical binding]; other site 768490014752 Switch I region; other site 768490014753 G2 box; other site 768490014754 G3 box; other site 768490014755 Switch II region; other site 768490014756 G4 box; other site 768490014757 G5 box; other site 768490014758 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 768490014759 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 768490014760 Antibiotic Binding Site [chemical binding]; other site 768490014761 elongation factor G; Reviewed; Region: PRK00007 768490014762 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 768490014763 G1 box; other site 768490014764 putative GEF interaction site [polypeptide binding]; other site 768490014765 GTP/Mg2+ binding site [chemical binding]; other site 768490014766 Switch I region; other site 768490014767 G2 box; other site 768490014768 G3 box; other site 768490014769 Switch II region; other site 768490014770 G4 box; other site 768490014771 G5 box; other site 768490014772 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 768490014773 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 768490014774 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 768490014775 30S ribosomal protein S7; Validated; Region: PRK05302 768490014776 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 768490014777 S17 interaction site [polypeptide binding]; other site 768490014778 S8 interaction site; other site 768490014779 16S rRNA interaction site [nucleotide binding]; other site 768490014780 streptomycin interaction site [chemical binding]; other site 768490014781 23S rRNA interaction site [nucleotide binding]; other site 768490014782 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 768490014783 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 768490014784 sulfur relay protein TusC; Validated; Region: PRK00211 768490014785 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 768490014786 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 768490014787 YheO-like PAS domain; Region: PAS_6; pfam08348 768490014788 HTH domain; Region: HTH_22; pfam13309 768490014789 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 768490014790 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 768490014791 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 768490014792 phi X174 lysis protein; Provisional; Region: PRK02793 768490014793 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737 768490014794 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 768490014795 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 768490014796 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 768490014797 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 768490014798 TrkA-N domain; Region: TrkA_N; pfam02254 768490014799 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 768490014800 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 768490014801 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768490014802 Walker A/P-loop; other site 768490014803 ATP binding site [chemical binding]; other site 768490014804 Q-loop/lid; other site 768490014805 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768490014806 ABC transporter; Region: ABC_tran_2; pfam12848 768490014807 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768490014808 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 768490014809 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 768490014810 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 768490014811 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490014812 dimer interface [polypeptide binding]; other site 768490014813 conserved gate region; other site 768490014814 putative PBP binding loops; other site 768490014815 ABC-ATPase subunit interface; other site 768490014816 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 768490014817 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 768490014818 Walker A/P-loop; other site 768490014819 ATP binding site [chemical binding]; other site 768490014820 Q-loop/lid; other site 768490014821 ABC transporter signature motif; other site 768490014822 Walker B; other site 768490014823 D-loop; other site 768490014824 H-loop/switch region; other site 768490014825 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 768490014826 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768490014827 substrate binding pocket [chemical binding]; other site 768490014828 membrane-bound complex binding site; other site 768490014829 hinge residues; other site 768490014830 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 768490014831 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 768490014832 putative hydrolase; Provisional; Region: PRK10985 768490014833 hypothetical protein; Provisional; Region: PRK04966 768490014834 phosphoribulokinase; Provisional; Region: PRK15453 768490014835 hypothetical protein; Provisional; Region: PRK10738 768490014836 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 768490014837 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 768490014838 ligand binding site [chemical binding]; other site 768490014839 flexible hinge region; other site 768490014840 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 768490014841 putative switch regulator; other site 768490014842 non-specific DNA interactions [nucleotide binding]; other site 768490014843 DNA binding site [nucleotide binding] 768490014844 sequence specific DNA binding site [nucleotide binding]; other site 768490014845 putative cAMP binding site [chemical binding]; other site 768490014846 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 768490014847 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 768490014848 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 768490014849 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 768490014850 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768490014851 inhibitor-cofactor binding pocket; inhibition site 768490014852 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490014853 catalytic residue [active] 768490014854 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 768490014855 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 768490014856 glutamine binding [chemical binding]; other site 768490014857 catalytic triad [active] 768490014858 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 768490014859 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 768490014860 Walker A motif; other site 768490014861 ATP binding site [chemical binding]; other site 768490014862 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 768490014863 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 768490014864 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490014865 active site 768490014866 phosphorylation site [posttranslational modification] 768490014867 intermolecular recognition site; other site 768490014868 dimerization interface [polypeptide binding]; other site 768490014869 LytTr DNA-binding domain; Region: LytTR; pfam04397 768490014870 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 768490014871 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 768490014872 GAF domain; Region: GAF; pfam01590 768490014873 Histidine kinase; Region: His_kinase; pfam06580 768490014874 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490014875 ATP binding site [chemical binding]; other site 768490014876 Mg2+ binding site [ion binding]; other site 768490014877 G-X-G motif; other site 768490014878 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 768490014879 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 768490014880 active site 768490014881 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 768490014882 active site 768490014883 methionine cluster; other site 768490014884 phosphorylation site [posttranslational modification] 768490014885 metal binding site [ion binding]; metal-binding site 768490014886 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 768490014887 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 768490014888 NAD binding site [chemical binding]; other site 768490014889 sugar binding site [chemical binding]; other site 768490014890 divalent metal binding site [ion binding]; other site 768490014891 tetramer (dimer of dimers) interface [polypeptide binding]; other site 768490014892 dimer interface [polypeptide binding]; other site 768490014893 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768490014894 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768490014895 DNA binding site [nucleotide binding] 768490014896 domain linker motif; other site 768490014897 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 768490014898 dimerization interface (closed form) [polypeptide binding]; other site 768490014899 ligand binding site [chemical binding]; other site 768490014900 putative transporter; Provisional; Region: PRK03699 768490014901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490014902 putative substrate translocation pore; other site 768490014903 cytosine deaminase; Provisional; Region: PRK09230 768490014904 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 768490014905 active site 768490014906 nitrite reductase subunit NirD; Provisional; Region: PRK14989 768490014907 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768490014908 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 768490014909 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 768490014910 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 768490014911 nitrite transporter NirC; Provisional; Region: PRK11562 768490014912 siroheme synthase; Provisional; Region: cysG; PRK10637 768490014913 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 768490014914 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 768490014915 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 768490014916 active site 768490014917 SAM binding site [chemical binding]; other site 768490014918 homodimer interface [polypeptide binding]; other site 768490014919 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 768490014920 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 768490014921 active site 768490014922 HIGH motif; other site 768490014923 dimer interface [polypeptide binding]; other site 768490014924 KMSKS motif; other site 768490014925 phosphoglycolate phosphatase; Provisional; Region: PRK13222 768490014926 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 768490014927 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768490014928 motif II; other site 768490014929 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 768490014930 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 768490014931 substrate binding site [chemical binding]; other site 768490014932 hexamer interface [polypeptide binding]; other site 768490014933 metal binding site [ion binding]; metal-binding site 768490014934 DNA adenine methylase; Provisional; Region: PRK10904 768490014935 hypothetical protein; Reviewed; Region: PRK11901 768490014936 cell division protein DamX; Validated; Region: PRK10905 768490014937 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 768490014938 active site 768490014939 dimer interface [polypeptide binding]; other site 768490014940 metal binding site [ion binding]; metal-binding site 768490014941 shikimate kinase; Reviewed; Region: aroK; PRK00131 768490014942 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 768490014943 ADP binding site [chemical binding]; other site 768490014944 magnesium binding site [ion binding]; other site 768490014945 putative shikimate binding site; other site 768490014946 putative outer membrane porin HofQ; Provisional; Region: hofQ; PRK13568 768490014947 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 768490014948 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 768490014949 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 768490014950 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 768490014951 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 768490014952 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 768490014953 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 768490014954 Transglycosylase; Region: Transgly; pfam00912 768490014955 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 768490014956 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 768490014957 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 768490014958 ADP-ribose binding site [chemical binding]; other site 768490014959 dimer interface [polypeptide binding]; other site 768490014960 active site 768490014961 nudix motif; other site 768490014962 metal binding site [ion binding]; metal-binding site 768490014963 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 768490014964 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 768490014965 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768490014966 motif II; other site 768490014967 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768490014968 RNA binding surface [nucleotide binding]; other site 768490014969 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 768490014970 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 768490014971 dimerization interface [polypeptide binding]; other site 768490014972 domain crossover interface; other site 768490014973 redox-dependent activation switch; other site 768490014974 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 768490014975 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 768490014976 active site 768490014977 substrate-binding site [chemical binding]; other site 768490014978 metal-binding site [ion binding] 768490014979 ATP binding site [chemical binding]; other site 768490014980 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 768490014981 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 768490014982 oligomeric interface; other site 768490014983 putative active site [active] 768490014984 homodimer interface [polypeptide binding]; other site 768490014985 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 768490014986 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768490014987 dimerization interface [polypeptide binding]; other site 768490014988 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768490014989 dimer interface [polypeptide binding]; other site 768490014990 phosphorylation site [posttranslational modification] 768490014991 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490014992 ATP binding site [chemical binding]; other site 768490014993 G-X-G motif; other site 768490014994 osmolarity response regulator; Provisional; Region: ompR; PRK09468 768490014995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490014996 active site 768490014997 phosphorylation site [posttranslational modification] 768490014998 intermolecular recognition site; other site 768490014999 dimerization interface [polypeptide binding]; other site 768490015000 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768490015001 DNA binding site [nucleotide binding] 768490015002 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 768490015003 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 768490015004 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 768490015005 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 768490015006 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 768490015007 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 768490015008 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 768490015009 RNA binding site [nucleotide binding]; other site 768490015010 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 768490015011 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 768490015012 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 768490015013 G1 box; other site 768490015014 GTP/Mg2+ binding site [chemical binding]; other site 768490015015 Switch I region; other site 768490015016 G2 box; other site 768490015017 G3 box; other site 768490015018 Switch II region; other site 768490015019 G4 box; other site 768490015020 G5 box; other site 768490015021 Nucleoside recognition; Region: Gate; pfam07670 768490015022 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 768490015023 Nucleoside recognition; Region: Gate; pfam07670 768490015024 FeoC like transcriptional regulator; Region: FeoC; cl17677 768490015025 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 768490015026 carboxylesterase BioH; Provisional; Region: PRK10349 768490015027 DNA utilization protein GntX; Provisional; Region: PRK11595 768490015028 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768490015029 active site 768490015030 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 768490015031 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 768490015032 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 768490015033 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 768490015034 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 768490015035 maltodextrin phosphorylase; Provisional; Region: PRK14985 768490015036 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 768490015037 active site pocket [active] 768490015038 transcriptional regulator MalT; Provisional; Region: PRK04841 768490015039 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768490015040 DNA binding residues [nucleotide binding] 768490015041 dimerization interface [polypeptide binding]; other site 768490015042 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 768490015043 active site residue [active] 768490015044 D-galactonate transporter; Region: 2A0114; TIGR00893 768490015045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490015046 putative substrate translocation pore; other site 768490015047 Domain of unknown function (DUF386); Region: DUF386; cl01047 768490015048 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 768490015049 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 768490015050 inhibitor site; inhibition site 768490015051 active site 768490015052 dimer interface [polypeptide binding]; other site 768490015053 catalytic residue [active] 768490015054 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 768490015055 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 768490015056 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 768490015057 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768490015058 substrate binding site [chemical binding]; other site 768490015059 dimer interface [polypeptide binding]; other site 768490015060 ATP binding site [chemical binding]; other site 768490015061 intramembrane serine protease GlpG; Provisional; Region: PRK10907 768490015062 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 768490015063 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 768490015064 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 768490015065 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 768490015066 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 768490015067 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 768490015068 glycogen phosphorylase; Provisional; Region: PRK14986 768490015069 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 768490015070 homodimer interface [polypeptide binding]; other site 768490015071 active site pocket [active] 768490015072 glycogen synthase; Provisional; Region: glgA; PRK00654 768490015073 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 768490015074 ADP-binding pocket [chemical binding]; other site 768490015075 homodimer interface [polypeptide binding]; other site 768490015076 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 768490015077 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 768490015078 ligand binding site; other site 768490015079 oligomer interface; other site 768490015080 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 768490015081 sulfate 1 binding site; other site 768490015082 glycogen debranching enzyme; Provisional; Region: PRK03705 768490015083 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 768490015084 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 768490015085 active site 768490015086 catalytic site [active] 768490015087 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 768490015088 glycogen branching enzyme; Provisional; Region: PRK05402 768490015089 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 768490015090 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 768490015091 active site 768490015092 catalytic site [active] 768490015093 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 768490015094 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 768490015095 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 768490015096 putative antibiotic transporter; Provisional; Region: PRK10739 768490015097 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 768490015098 ATP-binding site [chemical binding]; other site 768490015099 Gluconate-6-phosphate binding site [chemical binding]; other site 768490015100 high-affinity gluconate transporter; Provisional; Region: PRK14984 768490015101 gluconate transporter; Region: gntP; TIGR00791 768490015102 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 768490015103 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768490015104 DNA binding site [nucleotide binding] 768490015105 domain linker motif; other site 768490015106 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 768490015107 putative ligand binding site [chemical binding]; other site 768490015108 putative dimerization interface [polypeptide binding]; other site 768490015109 Pirin-related protein [General function prediction only]; Region: COG1741 768490015110 Pirin; Region: Pirin; pfam02678 768490015111 putative acetyltransferase YhhY; Provisional; Region: PRK10140 768490015112 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490015113 Coenzyme A binding pocket [chemical binding]; other site 768490015114 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 768490015115 putative active site pocket [active] 768490015116 cleavage site 768490015117 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 768490015118 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 768490015119 Metal-binding active site; metal-binding site 768490015120 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 768490015121 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768490015122 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768490015123 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 768490015124 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 768490015125 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768490015126 PYR/PP interface [polypeptide binding]; other site 768490015127 dimer interface [polypeptide binding]; other site 768490015128 TPP binding site [chemical binding]; other site 768490015129 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768490015130 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 768490015131 TPP-binding site; other site 768490015132 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768490015133 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 768490015134 substrate binding site [chemical binding]; other site 768490015135 ATP binding site [chemical binding]; other site 768490015136 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 768490015137 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 768490015138 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 768490015139 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768490015140 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768490015141 putative active site [active] 768490015142 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 768490015143 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 768490015144 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 768490015145 tetrameric interface [polypeptide binding]; other site 768490015146 NAD binding site [chemical binding]; other site 768490015147 catalytic residues [active] 768490015148 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 768490015149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490015150 putative substrate translocation pore; other site 768490015151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490015152 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 768490015153 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 768490015154 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 768490015155 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768490015156 Walker A/P-loop; other site 768490015157 ATP binding site [chemical binding]; other site 768490015158 Q-loop/lid; other site 768490015159 ABC transporter signature motif; other site 768490015160 Walker B; other site 768490015161 D-loop; other site 768490015162 H-loop/switch region; other site 768490015163 FaeA-like protein; Region: FaeA; pfam04703 768490015164 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 768490015165 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 768490015166 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 768490015167 Fimbrial protein; Region: Fimbrial; cl01416 768490015168 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 768490015169 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 768490015170 PapC N-terminal domain; Region: PapC_N; pfam13954 768490015171 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 768490015172 PapC C-terminal domain; Region: PapC_C; pfam13953 768490015173 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 768490015174 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 768490015175 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 768490015176 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 768490015177 Fimbrial protein; Region: Fimbrial; cl01416 768490015178 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 768490015179 O-Antigen ligase; Region: Wzy_C; pfam04932 768490015180 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 768490015181 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768490015182 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768490015183 DNA binding residues [nucleotide binding] 768490015184 dimerization interface [polypeptide binding]; other site 768490015185 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 768490015186 Amidinotransferase; Region: Amidinotransf; pfam02274 768490015187 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768490015188 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768490015189 putative DNA binding site [nucleotide binding]; other site 768490015190 putative Zn2+ binding site [ion binding]; other site 768490015191 AsnC family; Region: AsnC_trans_reg; pfam01037 768490015192 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 768490015193 active site 768490015194 Mn binding site [ion binding]; other site 768490015195 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502 768490015196 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 768490015197 Protein of unknown function (DUF330); Region: DUF330; pfam03886 768490015198 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 768490015199 mce related protein; Region: MCE; pfam02470 768490015200 mce related protein; Region: MCE; pfam02470 768490015201 mce related protein; Region: MCE; pfam02470 768490015202 Paraquat-inducible protein A; Region: PqiA; pfam04403 768490015203 Paraquat-inducible protein A; Region: PqiA; pfam04403 768490015204 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 768490015205 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768490015206 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768490015207 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 768490015208 Predicted flavoproteins [General function prediction only]; Region: COG2081 768490015209 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 768490015210 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 768490015211 universal stress protein UspB; Provisional; Region: PRK04960 768490015212 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 768490015213 Ligand Binding Site [chemical binding]; other site 768490015214 glutamate dehydrogenase; Provisional; Region: PRK09414 768490015215 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 768490015216 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 768490015217 NAD(P) binding site [chemical binding]; other site 768490015218 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 768490015219 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 768490015220 ligand binding site [chemical binding]; other site 768490015221 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 768490015222 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768490015223 Walker A/P-loop; other site 768490015224 ATP binding site [chemical binding]; other site 768490015225 Q-loop/lid; other site 768490015226 ABC transporter signature motif; other site 768490015227 Walker B; other site 768490015228 D-loop; other site 768490015229 H-loop/switch region; other site 768490015230 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768490015231 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768490015232 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768490015233 TM-ABC transporter signature motif; other site 768490015234 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768490015235 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768490015236 TM-ABC transporter signature motif; other site 768490015237 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 768490015238 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 768490015239 N- and C-terminal domain interface [polypeptide binding]; other site 768490015240 active site 768490015241 MgATP binding site [chemical binding]; other site 768490015242 catalytic site [active] 768490015243 metal binding site [ion binding]; metal-binding site 768490015244 carbohydrate binding site [chemical binding]; other site 768490015245 putative homodimer interface [polypeptide binding]; other site 768490015246 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 768490015247 putative active site [active] 768490015248 putative methyltransferase; Provisional; Region: PRK10742 768490015249 oligopeptidase A; Provisional; Region: PRK10911 768490015250 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 768490015251 active site 768490015252 Zn binding site [ion binding]; other site 768490015253 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 768490015254 nucleotide binding site/active site [active] 768490015255 HIT family signature motif; other site 768490015256 catalytic residue [active] 768490015257 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 768490015258 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 768490015259 glutathione reductase; Validated; Region: PRK06116 768490015260 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768490015261 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768490015262 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768490015263 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 768490015264 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 768490015265 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 768490015266 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 768490015267 haemagglutination activity domain; Region: Haemagg_act; pfam05860 768490015268 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768490015269 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768490015270 DNA binding residues [nucleotide binding] 768490015271 dimerization interface [polypeptide binding]; other site 768490015272 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 768490015273 O-Antigen ligase; Region: Wzy_C; pfam04932 768490015274 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 768490015275 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 768490015276 Fimbrial protein; Region: Fimbrial; pfam00419 768490015277 Fimbrial protein; Region: Fimbrial; pfam00419 768490015278 Fimbrial protein; Region: Fimbrial; cl01416 768490015279 fimbrial assembly chaperone StbE; Provisional; Region: PRK15246 768490015280 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 768490015281 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 768490015282 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 768490015283 PapC N-terminal domain; Region: PapC_N; pfam13954 768490015284 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 768490015285 PapC C-terminal domain; Region: PapC_C; pfam13953 768490015286 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 768490015287 Fimbrial protein; Region: Fimbrial; cl01416 768490015288 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 768490015289 DNA binding site [nucleotide binding] 768490015290 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 768490015291 DNA binding site [nucleotide binding] 768490015292 haemagglutination activity domain; Region: Haemagg_act; pfam05860 768490015293 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 768490015294 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 768490015295 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 768490015296 DinB family; Region: DinB; cl17821 768490015297 DinB superfamily; Region: DinB_2; pfam12867 768490015298 Cupin; Region: Cupin_6; pfam12852 768490015299 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490015300 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768490015301 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490015302 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 768490015303 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768490015304 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768490015305 dimer interface [polypeptide binding]; other site 768490015306 phosphorylation site [posttranslational modification] 768490015307 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490015308 ATP binding site [chemical binding]; other site 768490015309 Mg2+ binding site [ion binding]; other site 768490015310 G-X-G motif; other site 768490015311 Response regulator receiver domain; Region: Response_reg; pfam00072 768490015312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490015313 active site 768490015314 phosphorylation site [posttranslational modification] 768490015315 intermolecular recognition site; other site 768490015316 dimerization interface [polypeptide binding]; other site 768490015317 BetR domain; Region: BetR; pfam08667 768490015318 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 768490015319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 768490015320 active site 768490015321 phosphorylation site [posttranslational modification] 768490015322 intermolecular recognition site; other site 768490015323 dimerization interface [polypeptide binding]; other site 768490015324 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 768490015325 catalytic triad [active] 768490015326 putative active site [active] 768490015327 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 768490015328 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 768490015329 Autotransporter beta-domain; Region: Autotransporter; pfam03797 768490015330 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 768490015331 catalytic triad [active] 768490015332 putative active site [active] 768490015333 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 768490015334 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 768490015335 Autotransporter beta-domain; Region: Autotransporter; pfam03797 768490015336 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768490015337 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768490015338 hypothetical protein; Provisional; Region: PRK02399 768490015339 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 768490015340 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 768490015341 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 768490015342 dimer interface [polypeptide binding]; other site 768490015343 RNase II stability modulator; Provisional; Region: PRK10060 768490015344 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768490015345 putative active site [active] 768490015346 heme pocket [chemical binding]; other site 768490015347 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768490015348 metal binding site [ion binding]; metal-binding site 768490015349 active site 768490015350 I-site; other site 768490015351 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768490015352 enoyl-CoA hydratase; Validated; Region: PRK08788 768490015353 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768490015354 substrate binding site [chemical binding]; other site 768490015355 oxyanion hole (OAH) forming residues; other site 768490015356 trimer interface [polypeptide binding]; other site 768490015357 inner membrane protein YhjD; Region: TIGR00766 768490015358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490015359 metabolite-proton symporter; Region: 2A0106; TIGR00883 768490015360 putative substrate translocation pore; other site 768490015361 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 768490015362 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 768490015363 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 768490015364 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768490015365 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 768490015366 active site 1 [active] 768490015367 dimer interface [polypeptide binding]; other site 768490015368 hexamer interface [polypeptide binding]; other site 768490015369 active site 2 [active] 768490015370 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768490015371 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 768490015372 substrate binding site [chemical binding]; other site 768490015373 ATP binding site [chemical binding]; other site 768490015374 ketol-acid reductoisomerase; Validated; Region: PRK05225 768490015375 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 768490015376 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 768490015377 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 768490015378 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490015379 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 768490015380 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 768490015381 putative dimerization interface [polypeptide binding]; other site 768490015382 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 768490015383 threonine dehydratase; Reviewed; Region: PRK09224 768490015384 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 768490015385 tetramer interface [polypeptide binding]; other site 768490015386 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490015387 catalytic residue [active] 768490015388 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 768490015389 putative Ile/Val binding site [chemical binding]; other site 768490015390 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 768490015391 putative Ile/Val binding site [chemical binding]; other site 768490015392 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 768490015393 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 768490015394 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 768490015395 homodimer interface [polypeptide binding]; other site 768490015396 substrate-cofactor binding pocket; other site 768490015397 catalytic residue [active] 768490015398 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 768490015399 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 768490015400 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768490015401 PYR/PP interface [polypeptide binding]; other site 768490015402 dimer interface [polypeptide binding]; other site 768490015403 TPP binding site [chemical binding]; other site 768490015404 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768490015405 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 768490015406 TPP-binding site [chemical binding]; other site 768490015407 dimer interface [polypeptide binding]; other site 768490015408 ilvG operon leader peptide; Provisional; Region: PRK10424 768490015409 putative sialic acid transporter; Region: 2A0112; TIGR00891 768490015410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490015411 putative substrate translocation pore; other site 768490015412 putative ATP-dependent protease; Provisional; Region: PRK09862 768490015413 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 768490015414 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768490015415 Walker A motif; other site 768490015416 ATP binding site [chemical binding]; other site 768490015417 Walker B motif; other site 768490015418 arginine finger; other site 768490015419 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 768490015420 hypothetical protein; Provisional; Region: PRK11027 768490015421 transcriptional regulator HdfR; Provisional; Region: PRK03601 768490015422 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490015423 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768490015424 dimerization interface [polypeptide binding]; other site 768490015425 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768490015426 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768490015427 TM-ABC transporter signature motif; other site 768490015428 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768490015429 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768490015430 TM-ABC transporter signature motif; other site 768490015431 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 768490015432 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768490015433 Walker A/P-loop; other site 768490015434 ATP binding site [chemical binding]; other site 768490015435 Q-loop/lid; other site 768490015436 ABC transporter signature motif; other site 768490015437 Walker B; other site 768490015438 D-loop; other site 768490015439 H-loop/switch region; other site 768490015440 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768490015441 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 768490015442 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 768490015443 putative ligand binding site [chemical binding]; other site 768490015444 glutamate racemase; Provisional; Region: PRK00865 768490015445 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 768490015446 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768490015447 N-terminal plug; other site 768490015448 ligand-binding site [chemical binding]; other site 768490015449 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 768490015450 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490015451 S-adenosylmethionine binding site [chemical binding]; other site 768490015452 hypothetical protein; Provisional; Region: PRK11056 768490015453 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 768490015454 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768490015455 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 768490015456 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768490015457 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768490015458 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 768490015459 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490015460 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 768490015461 dimerization interface [polypeptide binding]; other site 768490015462 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 768490015463 catalytic triad [active] 768490015464 dimer interface [polypeptide binding]; other site 768490015465 Glutaredoxin (GRX) family, PRX5 hybrid subfamily; composed of hybrid proteins containing peroxiredoxin (PRX) and GRX domains, which is found in some pathogenic bacteria and cyanobacteria. PRXs are thiol-specific antioxidant (TSA) proteins that confer a...; Region: GRX_hybridPRX5; cd03029 768490015466 GSH binding site [chemical binding]; other site 768490015467 catalytic residues [active] 768490015468 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 768490015469 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768490015470 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768490015471 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768490015472 argininosuccinate lyase; Provisional; Region: PRK04833 768490015473 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 768490015474 active sites [active] 768490015475 tetramer interface [polypeptide binding]; other site 768490015476 argininosuccinate synthase; Provisional; Region: PRK13820 768490015477 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 768490015478 ANP binding site [chemical binding]; other site 768490015479 Substrate Binding Site II [chemical binding]; other site 768490015480 Substrate Binding Site I [chemical binding]; other site 768490015481 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 768490015482 nucleotide binding site [chemical binding]; other site 768490015483 N-acetyl-L-glutamate binding site [chemical binding]; other site 768490015484 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 768490015485 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 768490015486 acetylornithine deacetylase; Provisional; Region: PRK05111 768490015487 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 768490015488 metal binding site [ion binding]; metal-binding site 768490015489 putative dimer interface [polypeptide binding]; other site 768490015490 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 768490015491 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 768490015492 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768490015493 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490015494 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768490015495 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768490015496 LysE type translocator; Region: LysE; pfam01810 768490015497 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 768490015498 FAD binding site [chemical binding]; other site 768490015499 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 768490015500 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 768490015501 putative catalytic residues [active] 768490015502 putative nucleotide binding site [chemical binding]; other site 768490015503 putative aspartate binding site [chemical binding]; other site 768490015504 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 768490015505 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 768490015506 cystathionine gamma-synthase; Provisional; Region: PRK08045 768490015507 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 768490015508 homodimer interface [polypeptide binding]; other site 768490015509 substrate-cofactor binding pocket; other site 768490015510 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490015511 catalytic residue [active] 768490015512 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 768490015513 dimerization interface [polypeptide binding]; other site 768490015514 DNA binding site [nucleotide binding] 768490015515 corepressor binding sites; other site 768490015516 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 768490015517 primosome assembly protein PriA; Validated; Region: PRK05580 768490015518 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768490015519 ATP binding site [chemical binding]; other site 768490015520 putative Mg++ binding site [ion binding]; other site 768490015521 DAN domain; Region: DAN; cl17734 768490015522 helicase superfamily c-terminal domain; Region: HELICc; smart00490 768490015523 ATP-binding site [chemical binding]; other site 768490015524 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768490015525 DNA binding site [nucleotide binding] 768490015526 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 768490015527 domain linker motif; other site 768490015528 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 768490015529 dimerization interface [polypeptide binding]; other site 768490015530 ligand binding site [chemical binding]; other site 768490015531 Sporulation related domain; Region: SPOR; cl10051 768490015532 cell division protein FtsN; Provisional; Region: PRK12757 768490015533 Sporulation related domain; Region: SPOR; cl10051 768490015534 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 768490015535 active site 768490015536 HslU subunit interaction site [polypeptide binding]; other site 768490015537 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 768490015538 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768490015539 Walker A motif; other site 768490015540 ATP binding site [chemical binding]; other site 768490015541 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 768490015542 Walker B motif; other site 768490015543 arginine finger; other site 768490015544 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 768490015545 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 768490015546 UbiA prenyltransferase family; Region: UbiA; pfam01040 768490015547 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 768490015548 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3074 768490015549 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 768490015550 amphipathic channel; other site 768490015551 Asn-Pro-Ala signature motifs; other site 768490015552 glycerol kinase; Provisional; Region: glpK; PRK00047 768490015553 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 768490015554 N- and C-terminal domain interface [polypeptide binding]; other site 768490015555 active site 768490015556 MgATP binding site [chemical binding]; other site 768490015557 catalytic site [active] 768490015558 metal binding site [ion binding]; metal-binding site 768490015559 glycerol binding site [chemical binding]; other site 768490015560 homotetramer interface [polypeptide binding]; other site 768490015561 homodimer interface [polypeptide binding]; other site 768490015562 FBP binding site [chemical binding]; other site 768490015563 protein IIAGlc interface [polypeptide binding]; other site 768490015564 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 768490015565 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 768490015566 putative active site [active] 768490015567 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 768490015568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490015569 putative substrate translocation pore; other site 768490015570 Predicted transcriptional regulator [Transcription]; Region: COG2345 768490015571 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 768490015572 ferredoxin-NADP reductase; Provisional; Region: PRK10926 768490015573 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 768490015574 FAD binding pocket [chemical binding]; other site 768490015575 FAD binding motif [chemical binding]; other site 768490015576 phosphate binding motif [ion binding]; other site 768490015577 beta-alpha-beta structure motif; other site 768490015578 NAD binding pocket [chemical binding]; other site 768490015579 Predicted membrane protein [Function unknown]; Region: COG3152 768490015580 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 768490015581 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 768490015582 triosephosphate isomerase; Provisional; Region: PRK14567 768490015583 substrate binding site [chemical binding]; other site 768490015584 dimer interface [polypeptide binding]; other site 768490015585 catalytic triad [active] 768490015586 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768490015587 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 768490015588 substrate binding pocket [chemical binding]; other site 768490015589 membrane-bound complex binding site; other site 768490015590 hinge residues; other site 768490015591 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 768490015592 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 768490015593 active site 768490015594 ADP/pyrophosphate binding site [chemical binding]; other site 768490015595 dimerization interface [polypeptide binding]; other site 768490015596 allosteric effector site; other site 768490015597 fructose-1,6-bisphosphate binding site; other site 768490015598 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 768490015599 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 768490015600 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 768490015601 dimer interface [polypeptide binding]; other site 768490015602 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 768490015603 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490015604 active site 768490015605 phosphorylation site [posttranslational modification] 768490015606 intermolecular recognition site; other site 768490015607 dimerization interface [polypeptide binding]; other site 768490015608 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768490015609 DNA binding site [nucleotide binding] 768490015610 two-component sensor protein; Provisional; Region: cpxA; PRK09470 768490015611 HAMP domain; Region: HAMP; pfam00672 768490015612 dimerization interface [polypeptide binding]; other site 768490015613 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768490015614 dimer interface [polypeptide binding]; other site 768490015615 phosphorylation site [posttranslational modification] 768490015616 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490015617 ATP binding site [chemical binding]; other site 768490015618 Mg2+ binding site [ion binding]; other site 768490015619 G-X-G motif; other site 768490015620 putative rRNA methylase; Provisional; Region: PRK10358 768490015621 CHAD domain; Region: CHAD; pfam05235 768490015622 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 768490015623 serine acetyltransferase; Provisional; Region: cysE; PRK11132 768490015624 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 768490015625 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 768490015626 trimer interface [polypeptide binding]; other site 768490015627 active site 768490015628 substrate binding site [chemical binding]; other site 768490015629 CoA binding site [chemical binding]; other site 768490015630 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 768490015631 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 768490015632 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 768490015633 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 768490015634 SecA binding site; other site 768490015635 Preprotein binding site; other site 768490015636 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 768490015637 GSH binding site [chemical binding]; other site 768490015638 catalytic residues [active] 768490015639 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 768490015640 active site residue [active] 768490015641 phosphoglyceromutase; Provisional; Region: PRK05434 768490015642 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 768490015643 AmiB activator; Provisional; Region: PRK11637 768490015644 Peptidase family M23; Region: Peptidase_M23; pfam01551 768490015645 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 768490015646 NodB motif; other site 768490015647 putative active site [active] 768490015648 putative catalytic site [active] 768490015649 Zn binding site [ion binding]; other site 768490015650 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 768490015651 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 768490015652 NAD(P) binding site [chemical binding]; other site 768490015653 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 768490015654 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 768490015655 substrate-cofactor binding pocket; other site 768490015656 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768490015657 catalytic residue [active] 768490015658 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 768490015659 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 768490015660 NADP binding site [chemical binding]; other site 768490015661 homopentamer interface [polypeptide binding]; other site 768490015662 substrate binding site [chemical binding]; other site 768490015663 active site 768490015664 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 768490015665 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 768490015666 putative active site [active] 768490015667 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 768490015668 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 768490015669 putative active site [active] 768490015670 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768490015671 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 768490015672 putative glycosyl transferase; Provisional; Region: PRK10073 768490015673 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 768490015674 active site 768490015675 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 768490015676 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 768490015677 putative active site [active] 768490015678 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 768490015679 putative active site [active] 768490015680 putative catalytic site [active] 768490015681 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 768490015682 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 768490015683 putative active site [active] 768490015684 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768490015685 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 768490015686 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768490015687 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 768490015688 putative ADP-binding pocket [chemical binding]; other site 768490015689 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 768490015690 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 768490015691 putative active site [active] 768490015692 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 768490015693 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 768490015694 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 768490015695 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 768490015696 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 768490015697 putative metal binding site; other site 768490015698 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 768490015699 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 768490015700 active site 768490015701 (T/H)XGH motif; other site 768490015702 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 768490015703 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 768490015704 DNA binding site [nucleotide binding] 768490015705 catalytic residue [active] 768490015706 H2TH interface [polypeptide binding]; other site 768490015707 putative catalytic residues [active] 768490015708 turnover-facilitating residue; other site 768490015709 intercalation triad [nucleotide binding]; other site 768490015710 8OG recognition residue [nucleotide binding]; other site 768490015711 putative reading head residues; other site 768490015712 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 768490015713 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 768490015714 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 768490015715 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 768490015716 hypothetical protein; Reviewed; Region: PRK00024 768490015717 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 768490015718 MPN+ (JAMM) motif; other site 768490015719 Zinc-binding site [ion binding]; other site 768490015720 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 768490015721 Flavoprotein; Region: Flavoprotein; pfam02441 768490015722 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 768490015723 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 768490015724 trimer interface [polypeptide binding]; other site 768490015725 active site 768490015726 division inhibitor protein; Provisional; Region: slmA; PRK09480 768490015727 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768490015728 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768490015729 active site 768490015730 ribonuclease PH; Reviewed; Region: rph; PRK00173 768490015731 Ribonuclease PH; Region: RNase_PH_bact; cd11362 768490015732 hexamer interface [polypeptide binding]; other site 768490015733 active site 768490015734 hypothetical protein; Provisional; Region: PRK11820 768490015735 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 768490015736 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 768490015737 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 768490015738 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 768490015739 Nucleoside recognition; Region: Gate; pfam07670 768490015740 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 768490015741 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 768490015742 Predicted membrane protein [Function unknown]; Region: COG2860 768490015743 UPF0126 domain; Region: UPF0126; pfam03458 768490015744 UPF0126 domain; Region: UPF0126; pfam03458 768490015745 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768490015746 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768490015747 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 768490015748 putative effector binding pocket; other site 768490015749 putative dimerization interface [polypeptide binding]; other site 768490015750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490015751 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768490015752 putative substrate translocation pore; other site 768490015753 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 768490015754 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 768490015755 catalytic site [active] 768490015756 G-X2-G-X-G-K; other site 768490015757 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 768490015758 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 768490015759 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768490015760 Zn2+ binding site [ion binding]; other site 768490015761 Mg2+ binding site [ion binding]; other site 768490015762 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 768490015763 synthetase active site [active] 768490015764 NTP binding site [chemical binding]; other site 768490015765 metal binding site [ion binding]; metal-binding site 768490015766 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 768490015767 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 768490015768 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 768490015769 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 768490015770 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 768490015771 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 768490015772 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 768490015773 generic binding surface II; other site 768490015774 ssDNA binding site; other site 768490015775 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768490015776 ATP binding site [chemical binding]; other site 768490015777 putative Mg++ binding site [ion binding]; other site 768490015778 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768490015779 nucleotide binding region [chemical binding]; other site 768490015780 ATP-binding site [chemical binding]; other site 768490015781 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 768490015782 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 768490015783 AsmA family; Region: AsmA; pfam05170 768490015784 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768490015785 Coenzyme A binding pocket [chemical binding]; other site 768490015786 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 768490015787 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 768490015788 putative active site [active] 768490015789 dimerization interface [polypeptide binding]; other site 768490015790 putative tRNAtyr binding site [nucleotide binding]; other site 768490015791 hypothetical protein; Reviewed; Region: PRK01637 768490015792 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 768490015793 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768490015794 motif II; other site 768490015795 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 768490015796 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 768490015797 G1 box; other site 768490015798 putative GEF interaction site [polypeptide binding]; other site 768490015799 GTP/Mg2+ binding site [chemical binding]; other site 768490015800 Switch I region; other site 768490015801 G2 box; other site 768490015802 G3 box; other site 768490015803 Switch II region; other site 768490015804 G4 box; other site 768490015805 G5 box; other site 768490015806 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 768490015807 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 768490015808 glutamine synthetase; Provisional; Region: glnA; PRK09469 768490015809 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 768490015810 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 768490015811 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 768490015812 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768490015813 dimer interface [polypeptide binding]; other site 768490015814 phosphorylation site [posttranslational modification] 768490015815 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768490015816 ATP binding site [chemical binding]; other site 768490015817 Mg2+ binding site [ion binding]; other site 768490015818 G-X-G motif; other site 768490015819 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 768490015820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768490015821 active site 768490015822 phosphorylation site [posttranslational modification] 768490015823 intermolecular recognition site; other site 768490015824 dimerization interface [polypeptide binding]; other site 768490015825 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768490015826 Walker A motif; other site 768490015827 ATP binding site [chemical binding]; other site 768490015828 Walker B motif; other site 768490015829 arginine finger; other site 768490015830 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768490015831 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 768490015832 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768490015833 FeS/SAM binding site; other site 768490015834 HemN C-terminal domain; Region: HemN_C; pfam06969 768490015835 Der GTPase activator; Provisional; Region: PRK05244 768490015836 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 768490015837 G1 box; other site 768490015838 GTP/Mg2+ binding site [chemical binding]; other site 768490015839 Switch I region; other site 768490015840 G2 box; other site 768490015841 G3 box; other site 768490015842 Switch II region; other site 768490015843 G4 box; other site 768490015844 G5 box; other site 768490015845 DNA polymerase I; Provisional; Region: PRK05755 768490015846 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 768490015847 active site 768490015848 metal binding site 1 [ion binding]; metal-binding site 768490015849 putative 5' ssDNA interaction site; other site 768490015850 metal binding site 3; metal-binding site 768490015851 metal binding site 2 [ion binding]; metal-binding site 768490015852 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 768490015853 putative DNA binding site [nucleotide binding]; other site 768490015854 putative metal binding site [ion binding]; other site 768490015855 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 768490015856 active site 768490015857 catalytic site [active] 768490015858 substrate binding site [chemical binding]; other site 768490015859 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 768490015860 active site 768490015861 DNA binding site [nucleotide binding] 768490015862 catalytic site [active] 768490015863 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 768490015864 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 768490015865 putative acyl-acceptor binding pocket; other site 768490015866 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 768490015867 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 768490015868 catalytic residues [active] 768490015869 hinge region; other site 768490015870 alpha helical domain; other site 768490015871 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 768490015872 serine/threonine protein kinase; Provisional; Region: PRK11768 768490015873 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 768490015874 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 768490015875 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 768490015876 GTP binding site; other site 768490015877 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 768490015878 Walker A motif; other site 768490015879 Transcriptional regulators [Transcription]; Region: FadR; COG2186 768490015880 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768490015881 DNA-binding site [nucleotide binding]; DNA binding site 768490015882 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 768490015883 putative transporter; Provisional; Region: PRK10504 768490015884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768490015885 putative substrate translocation pore; other site 768490015886 transcriptional repressor RbsR; Provisional; Region: PRK10423 768490015887 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768490015888 DNA binding site [nucleotide binding] 768490015889 domain linker motif; other site 768490015890 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 768490015891 dimerization interface [polypeptide binding]; other site 768490015892 ligand binding site [chemical binding]; other site 768490015893 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768490015894 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 768490015895 substrate binding site [chemical binding]; other site 768490015896 dimer interface [polypeptide binding]; other site 768490015897 ATP binding site [chemical binding]; other site 768490015898 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 768490015899 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 768490015900 ligand binding site [chemical binding]; other site 768490015901 dimerization interface [polypeptide binding]; other site 768490015902 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768490015903 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768490015904 TM-ABC transporter signature motif; other site 768490015905 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 768490015906 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768490015907 Walker A/P-loop; other site 768490015908 ATP binding site [chemical binding]; other site 768490015909 Q-loop/lid; other site 768490015910 ABC transporter signature motif; other site 768490015911 Walker B; other site 768490015912 D-loop; other site 768490015913 H-loop/switch region; other site 768490015914 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768490015915 D-ribose pyranase; Provisional; Region: PRK11797 768490015916 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 768490015917 potassium uptake protein; Region: kup; TIGR00794 768490015918 regulatory ATPase RavA; Provisional; Region: PRK13531 768490015919 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768490015920 Walker A motif; other site 768490015921 ATP binding site [chemical binding]; other site 768490015922 Walker B motif; other site 768490015923 arginine finger; other site 768490015924 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 768490015925 hypothetical protein; Provisional; Region: yieM; PRK10997 768490015926 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 768490015927 metal ion-dependent adhesion site (MIDAS); other site 768490015928 Asparagine synthetase A [Amino acid transport and metabolism]; Region: AsnA; COG2502 768490015929 motif 1; other site 768490015930 dimer interface [polypeptide binding]; other site 768490015931 active site 768490015932 motif 2; other site 768490015933 motif 3; other site 768490015934 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 768490015935 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768490015936 dimerization interface [polypeptide binding]; other site 768490015937 putative DNA binding site [nucleotide binding]; other site 768490015938 putative Zn2+ binding site [ion binding]; other site 768490015939 AsnC family; Region: AsnC_trans_reg; pfam01037 768490015940 FMN-binding protein MioC; Provisional; Region: PRK09004 768490015941 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 768490015942 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 768490015943 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 768490015944 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 768490015945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768490015946 S-adenosylmethionine binding site [chemical binding]; other site 768490015947 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 768490015948 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 768490015949 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 768490015950 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 768490015951 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 768490015952 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 768490015953 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 768490015954 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 768490015955 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 768490015956 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 768490015957 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 768490015958 beta subunit interaction interface [polypeptide binding]; other site 768490015959 Walker A motif; other site 768490015960 ATP binding site [chemical binding]; other site 768490015961 Walker B motif; other site 768490015962 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 768490015963 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 768490015964 core domain interface [polypeptide binding]; other site 768490015965 delta subunit interface [polypeptide binding]; other site 768490015966 epsilon subunit interface [polypeptide binding]; other site 768490015967 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 768490015968 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 768490015969 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 768490015970 alpha subunit interaction interface [polypeptide binding]; other site 768490015971 Walker A motif; other site 768490015972 ATP binding site [chemical binding]; other site 768490015973 Walker B motif; other site 768490015974 inhibitor binding site; inhibition site 768490015975 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 768490015976 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 768490015977 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 768490015978 gamma subunit interface [polypeptide binding]; other site 768490015979 epsilon subunit interface [polypeptide binding]; other site 768490015980 LBP interface [polypeptide binding]; other site 768490015981 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 768490015982 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 768490015983 Substrate binding site; other site 768490015984 Mg++ binding site; other site 768490015985 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 768490015986 active site 768490015987 substrate binding site [chemical binding]; other site 768490015988 CoA binding site [chemical binding]; other site 768490015989 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 768490015990 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 768490015991 glutaminase active site [active] 768490015992 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 768490015993 dimer interface [polypeptide binding]; other site 768490015994 active site 768490015995 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 768490015996 dimer interface [polypeptide binding]; other site 768490015997 active site 768490015998 AAA domain; Region: AAA_13; pfam13166 768490015999 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768490016000 substrate binding pocket [chemical binding]; other site 768490016001 membrane-bound complex binding site; other site 768490016002 hinge residues; other site 768490016003 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 768490016004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490016005 dimer interface [polypeptide binding]; other site 768490016006 conserved gate region; other site 768490016007 putative PBP binding loops; other site 768490016008 ABC-ATPase subunit interface; other site 768490016009 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 768490016010 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490016011 dimer interface [polypeptide binding]; other site 768490016012 conserved gate region; other site 768490016013 putative PBP binding loops; other site 768490016014 ABC-ATPase subunit interface; other site 768490016015 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 768490016016 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 768490016017 Walker A/P-loop; other site 768490016018 ATP binding site [chemical binding]; other site 768490016019 Q-loop/lid; other site 768490016020 ABC transporter signature motif; other site 768490016021 Walker B; other site 768490016022 D-loop; other site 768490016023 H-loop/switch region; other site 768490016024 transcriptional regulator PhoU; Provisional; Region: PRK11115 768490016025 PhoU domain; Region: PhoU; pfam01895 768490016026 PhoU domain; Region: PhoU; pfam01895 768490016027 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768490016028 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768490016029 substrate binding pocket [chemical binding]; other site 768490016030 membrane-bound complex binding site; other site 768490016031 hinge residues; other site 768490016032 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490016033 dimer interface [polypeptide binding]; other site 768490016034 conserved gate region; other site 768490016035 putative PBP binding loops; other site 768490016036 ABC-ATPase subunit interface; other site 768490016037 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768490016038 dimer interface [polypeptide binding]; other site 768490016039 conserved gate region; other site 768490016040 putative PBP binding loops; other site 768490016041 ABC-ATPase subunit interface; other site 768490016042 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 768490016043 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768490016044 motif II; other site 768490016045 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 768490016046 Predicted esterase [General function prediction only]; Region: COG0400 768490016047 Predicted flavoprotein [General function prediction only]; Region: COG0431 768490016048 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768490016049 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 768490016050 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 768490016051 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 768490016052 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 768490016053 trmE is a tRNA modification GTPase; Region: trmE; cd04164 768490016054 G1 box; other site 768490016055 GTP/Mg2+ binding site [chemical binding]; other site 768490016056 Switch I region; other site 768490016057 G2 box; other site 768490016058 Switch II region; other site 768490016059 G3 box; other site 768490016060 G4 box; other site 768490016061 G5 box; other site 768490016062 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 768490016063 membrane protein insertase; Provisional; Region: PRK01318 768490016064 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 768490016065 hypothetical protein; Validated; Region: PRK00041 768490016066 ribonuclease P; Reviewed; Region: rnpA; PRK01732 768490016067 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399