-- dump date 20140620_062304 -- class Genbank::misc_feature -- table misc_feature_note -- id note 768493000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 768493000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 768493000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768493000004 Walker A motif; other site 768493000005 ATP binding site [chemical binding]; other site 768493000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 768493000007 Walker B motif; other site 768493000008 arginine finger; other site 768493000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 768493000010 DnaA box-binding interface [nucleotide binding]; other site 768493000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 768493000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 768493000013 putative DNA binding surface [nucleotide binding]; other site 768493000014 dimer interface [polypeptide binding]; other site 768493000015 beta-clamp/clamp loader binding surface; other site 768493000016 beta-clamp/translesion DNA polymerase binding surface; other site 768493000017 recF protein; Region: recf; TIGR00611 768493000018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768493000019 Walker A/P-loop; other site 768493000020 ATP binding site [chemical binding]; other site 768493000021 Q-loop/lid; other site 768493000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768493000023 ABC transporter signature motif; other site 768493000024 Walker B; other site 768493000025 D-loop; other site 768493000026 H-loop/switch region; other site 768493000027 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 768493000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493000029 Mg2+ binding site [ion binding]; other site 768493000030 G-X-G motif; other site 768493000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 768493000032 anchoring element; other site 768493000033 dimer interface [polypeptide binding]; other site 768493000034 ATP binding site [chemical binding]; other site 768493000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 768493000036 active site 768493000037 putative metal-binding site [ion binding]; other site 768493000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 768493000039 sugar phosphate phosphatase; Provisional; Region: PRK10513 768493000040 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768493000041 active site 768493000042 motif I; other site 768493000043 motif II; other site 768493000044 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768493000045 motif I; other site 768493000046 active site 768493000047 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 768493000048 ornithine cyclodeaminase; Validated; Region: PRK06823 768493000049 hypothetical protein; Provisional; Region: PRK06815 768493000050 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 768493000051 tetramer interface [polypeptide binding]; other site 768493000052 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493000053 catalytic residue [active] 768493000054 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 768493000055 hypothetical protein; Provisional; Region: PRK11616 768493000056 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 768493000057 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 768493000058 putative dimer interface [polypeptide binding]; other site 768493000059 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 768493000060 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 768493000061 putative dimer interface [polypeptide binding]; other site 768493000062 putative transporter; Validated; Region: PRK03818 768493000063 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 768493000064 TrkA-C domain; Region: TrkA_C; pfam02080 768493000065 TrkA-C domain; Region: TrkA_C; pfam02080 768493000066 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 768493000067 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 768493000068 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768493000069 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493000070 homodimer interface [polypeptide binding]; other site 768493000071 catalytic residue [active] 768493000072 alpha-amylase; Reviewed; Region: malS; PRK09505 768493000073 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 768493000074 active site 768493000075 catalytic site [active] 768493000076 Predicted transcriptional regulator [Transcription]; Region: COG3905 768493000077 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 768493000078 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 768493000079 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 768493000080 dimerization interface [polypeptide binding]; other site 768493000081 ligand binding site [chemical binding]; other site 768493000082 NADP binding site [chemical binding]; other site 768493000083 catalytic site [active] 768493000084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493000085 D-galactonate transporter; Region: 2A0114; TIGR00893 768493000086 putative substrate translocation pore; other site 768493000087 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768493000088 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 768493000089 substrate binding site [chemical binding]; other site 768493000090 ATP binding site [chemical binding]; other site 768493000091 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 768493000092 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768493000093 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768493000094 DNA binding site [nucleotide binding] 768493000095 domain linker motif; other site 768493000096 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 768493000097 putative dimerization interface [polypeptide binding]; other site 768493000098 putative ligand binding site [chemical binding]; other site 768493000099 putative outer membrane lipoprotein; Provisional; Region: PRK10510 768493000100 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 768493000101 ligand binding site [chemical binding]; other site 768493000102 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768493000103 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493000104 Coenzyme A binding pocket [chemical binding]; other site 768493000105 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 768493000106 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 768493000107 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 768493000108 active site 768493000109 catalytic triad [active] 768493000110 oxyanion hole [active] 768493000111 Autotransporter beta-domain; Region: Autotransporter; cl17461 768493000112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493000113 D-galactonate transporter; Region: 2A0114; TIGR00893 768493000114 putative substrate translocation pore; other site 768493000115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493000116 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 768493000117 dimer interface [polypeptide binding]; other site 768493000118 motif 1; other site 768493000119 active site 768493000120 motif 2; other site 768493000121 motif 3; other site 768493000122 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 768493000123 DALR anticodon binding domain; Region: DALR_1; pfam05746 768493000124 Fic family protein [Function unknown]; Region: COG3177 768493000125 Fic/DOC family; Region: Fic; pfam02661 768493000126 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 768493000127 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 768493000128 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 768493000129 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 768493000130 active site 768493000131 P-loop; other site 768493000132 phosphorylation site [posttranslational modification] 768493000133 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 768493000134 active site 768493000135 phosphorylation site [posttranslational modification] 768493000136 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 768493000137 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 768493000138 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 768493000139 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 768493000140 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 768493000141 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 768493000142 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768493000143 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768493000144 DNA-binding site [nucleotide binding]; DNA binding site 768493000145 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768493000146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493000147 homodimer interface [polypeptide binding]; other site 768493000148 catalytic residue [active] 768493000149 hypothetical protein; Provisional; Region: PRK11020 768493000150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493000151 S-adenosylmethionine binding site [chemical binding]; other site 768493000152 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 768493000153 MOSC domain; Region: MOSC; pfam03473 768493000154 3-alpha domain; Region: 3-alpha; pfam03475 768493000155 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768493000156 dimerization interface [polypeptide binding]; other site 768493000157 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 768493000158 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768493000159 dimer interface [polypeptide binding]; other site 768493000160 putative CheW interface [polypeptide binding]; other site 768493000161 superoxide dismutase; Provisional; Region: PRK10925 768493000162 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 768493000163 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 768493000164 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 768493000165 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 768493000166 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 768493000167 [4Fe-4S] binding site [ion binding]; other site 768493000168 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 768493000169 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 768493000170 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 768493000171 molybdopterin cofactor binding site; other site 768493000172 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 768493000173 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 768493000174 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 768493000175 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 768493000176 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 768493000177 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 768493000178 hypothetical protein; Provisional; Region: PRK11615 768493000179 putative glutathione S-transferase; Provisional; Region: PRK10357 768493000180 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 768493000181 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 768493000182 dimer interface [polypeptide binding]; other site 768493000183 N-terminal domain interface [polypeptide binding]; other site 768493000184 putative substrate binding pocket (H-site) [chemical binding]; other site 768493000185 selenocysteine synthase; Provisional; Region: PRK04311 768493000186 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 768493000187 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 768493000188 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768493000189 catalytic residue [active] 768493000190 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 768493000191 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 768493000192 G1 box; other site 768493000193 putative GEF interaction site [polypeptide binding]; other site 768493000194 GTP/Mg2+ binding site [chemical binding]; other site 768493000195 Switch I region; other site 768493000196 G2 box; other site 768493000197 G3 box; other site 768493000198 Switch II region; other site 768493000199 G4 box; other site 768493000200 G5 box; other site 768493000201 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 768493000202 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 768493000203 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 768493000204 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 768493000205 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 768493000206 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 768493000207 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 768493000208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493000209 putative substrate translocation pore; other site 768493000210 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 768493000211 Acyltransferase family; Region: Acyl_transf_3; pfam01757 768493000212 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 768493000213 conserved cys residue [active] 768493000214 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493000215 Isochorismatase family; Region: Isochorismatase; pfam00857 768493000216 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 768493000217 catalytic triad [active] 768493000218 conserved cis-peptide bond; other site 768493000219 putative deaminase; Validated; Region: PRK06846 768493000220 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 768493000221 active site 768493000222 xylulokinase; Provisional; Region: PRK15027 768493000223 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 768493000224 N- and C-terminal domain interface [polypeptide binding]; other site 768493000225 active site 768493000226 MgATP binding site [chemical binding]; other site 768493000227 catalytic site [active] 768493000228 metal binding site [ion binding]; metal-binding site 768493000229 xylulose binding site [chemical binding]; other site 768493000230 homodimer interface [polypeptide binding]; other site 768493000231 xylose isomerase; Provisional; Region: PRK05474 768493000232 xylose isomerase; Region: xylose_isom_A; TIGR02630 768493000233 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 768493000234 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 768493000235 putative ligand binding site [chemical binding]; other site 768493000236 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 768493000237 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768493000238 Walker A/P-loop; other site 768493000239 ATP binding site [chemical binding]; other site 768493000240 Q-loop/lid; other site 768493000241 ABC transporter signature motif; other site 768493000242 Walker B; other site 768493000243 D-loop; other site 768493000244 H-loop/switch region; other site 768493000245 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768493000246 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 768493000247 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768493000248 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768493000249 TM-ABC transporter signature motif; other site 768493000250 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 768493000251 putative dimerization interface [polypeptide binding]; other site 768493000252 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768493000253 putative ligand binding site [chemical binding]; other site 768493000254 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493000255 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768493000256 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493000257 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493000258 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768493000259 dimerization interface [polypeptide binding]; other site 768493000260 putative cyanate transporter; Provisional; Region: cynX; PRK09705 768493000261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493000262 putative substrate translocation pore; other site 768493000263 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 768493000264 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 768493000265 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 768493000266 active site 768493000267 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 768493000268 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 768493000269 putative active site [active] 768493000270 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768493000271 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 768493000272 Walker A/P-loop; other site 768493000273 ATP binding site [chemical binding]; other site 768493000274 Q-loop/lid; other site 768493000275 ABC transporter signature motif; other site 768493000276 Walker B; other site 768493000277 D-loop; other site 768493000278 H-loop/switch region; other site 768493000279 HlyD family secretion protein; Region: HlyD; pfam00529 768493000280 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768493000281 HlyD family secretion protein; Region: HlyD_3; pfam13437 768493000282 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 768493000283 active site 768493000284 NTP binding site [chemical binding]; other site 768493000285 metal binding triad [ion binding]; metal-binding site 768493000286 Autoinducer binding domain; Region: Autoind_bind; pfam03472 768493000287 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768493000288 DNA binding residues [nucleotide binding] 768493000289 dimerization interface [polypeptide binding]; other site 768493000290 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 768493000291 catalytic core [active] 768493000292 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 768493000293 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768493000294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493000295 putative substrate translocation pore; other site 768493000296 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493000297 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493000298 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768493000299 putative effector binding pocket; other site 768493000300 dimerization interface [polypeptide binding]; other site 768493000301 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 768493000302 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768493000303 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768493000304 NAD(P) binding site [chemical binding]; other site 768493000305 active site 768493000306 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493000307 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493000308 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768493000309 dimerization interface [polypeptide binding]; other site 768493000310 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 768493000311 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768493000312 NAD(P) binding site [chemical binding]; other site 768493000313 active site 768493000314 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 768493000315 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768493000316 active site turn [active] 768493000317 phosphorylation site [posttranslational modification] 768493000318 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768493000319 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 768493000320 HPr interaction site; other site 768493000321 glycerol kinase (GK) interaction site [polypeptide binding]; other site 768493000322 active site 768493000323 phosphorylation site [posttranslational modification] 768493000324 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 768493000325 beta-galactosidase; Region: BGL; TIGR03356 768493000326 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 768493000327 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 768493000328 HD domain; Region: HD_4; pfam13328 768493000329 Transcriptional regulators [Transcription]; Region: MarR; COG1846 768493000330 MarR family; Region: MarR; pfam01047 768493000331 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 768493000332 phosphoethanolamine transferase; Provisional; Region: PRK11560 768493000333 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 768493000334 Sulfatase; Region: Sulfatase; pfam00884 768493000335 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 768493000336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493000337 active site 768493000338 phosphorylation site [posttranslational modification] 768493000339 intermolecular recognition site; other site 768493000340 dimerization interface [polypeptide binding]; other site 768493000341 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768493000342 DNA binding residues [nucleotide binding] 768493000343 dimerization interface [polypeptide binding]; other site 768493000344 sensory histidine kinase UhpB; Provisional; Region: PRK11644 768493000345 MASE1; Region: MASE1; cl17823 768493000346 MASE1; Region: MASE1; cl17823 768493000347 Histidine kinase; Region: HisKA_3; pfam07730 768493000348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493000349 ATP binding site [chemical binding]; other site 768493000350 Mg2+ binding site [ion binding]; other site 768493000351 G-X-G motif; other site 768493000352 regulatory protein UhpC; Provisional; Region: PRK11663 768493000353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493000354 putative substrate translocation pore; other site 768493000355 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493000356 Predicted transcriptional regulator [Transcription]; Region: COG4190 768493000357 N-terminal Early set domain associated with the catalytic domain of chitinase; Region: E_set_Chitinase_N; cd02848 768493000358 Glyco_18 domain; Region: Glyco_18; smart00636 768493000359 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 768493000360 active site 768493000361 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 768493000362 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 768493000363 peptide binding site [polypeptide binding]; other site 768493000364 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 768493000365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493000366 dimer interface [polypeptide binding]; other site 768493000367 conserved gate region; other site 768493000368 putative PBP binding loops; other site 768493000369 ABC-ATPase subunit interface; other site 768493000370 dipeptide transporter; Provisional; Region: PRK10913 768493000371 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 768493000372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493000373 dimer interface [polypeptide binding]; other site 768493000374 conserved gate region; other site 768493000375 putative PBP binding loops; other site 768493000376 ABC-ATPase subunit interface; other site 768493000377 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 768493000378 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768493000379 Walker A/P-loop; other site 768493000380 ATP binding site [chemical binding]; other site 768493000381 Q-loop/lid; other site 768493000382 ABC transporter signature motif; other site 768493000383 Walker B; other site 768493000384 D-loop; other site 768493000385 H-loop/switch region; other site 768493000386 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768493000387 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 768493000388 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768493000389 Walker A/P-loop; other site 768493000390 ATP binding site [chemical binding]; other site 768493000391 Q-loop/lid; other site 768493000392 ABC transporter signature motif; other site 768493000393 Walker B; other site 768493000394 D-loop; other site 768493000395 H-loop/switch region; other site 768493000396 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 768493000397 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 768493000398 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 768493000399 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 768493000400 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 768493000401 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 768493000402 YhjQ protein; Region: YhjQ; pfam06564 768493000403 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 768493000404 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 768493000405 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 768493000406 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 768493000407 DXD motif; other site 768493000408 PilZ domain; Region: PilZ; pfam07238 768493000409 cellulose synthase regulator protein; Provisional; Region: PRK11114 768493000410 endo-1,4-D-glucanase; Provisional; Region: PRK11097 768493000411 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 768493000412 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768493000413 TPR motif; other site 768493000414 binding surface 768493000415 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768493000416 binding surface 768493000417 TPR motif; other site 768493000418 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768493000419 binding surface 768493000420 TPR motif; other site 768493000421 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 768493000422 putative diguanylate cyclase; Provisional; Region: PRK13561 768493000423 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768493000424 metal binding site [ion binding]; metal-binding site 768493000425 active site 768493000426 I-site; other site 768493000427 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768493000428 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 768493000429 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 768493000430 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 768493000431 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 768493000432 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 768493000433 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 768493000434 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 768493000435 Part of AAA domain; Region: AAA_19; pfam13245 768493000436 Family description; Region: UvrD_C_2; pfam13538 768493000437 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 768493000438 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 768493000439 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 768493000440 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 768493000441 ATP binding site [chemical binding]; other site 768493000442 Mg++ binding site [ion binding]; other site 768493000443 motif III; other site 768493000444 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768493000445 nucleotide binding region [chemical binding]; other site 768493000446 ATP-binding site [chemical binding]; other site 768493000447 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 768493000448 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 768493000449 catalytic residues [active] 768493000450 transcription termination factor Rho; Provisional; Region: rho; PRK09376 768493000451 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 768493000452 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 768493000453 RNA binding site [nucleotide binding]; other site 768493000454 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 768493000455 multimer interface [polypeptide binding]; other site 768493000456 Walker A motif; other site 768493000457 ATP binding site [chemical binding]; other site 768493000458 Walker B motif; other site 768493000459 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 768493000460 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 768493000461 Mg++ binding site [ion binding]; other site 768493000462 putative catalytic motif [active] 768493000463 substrate binding site [chemical binding]; other site 768493000464 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 768493000465 Chain length determinant protein; Region: Wzz; cl15801 768493000466 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 768493000467 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 768493000468 active site 768493000469 homodimer interface [polypeptide binding]; other site 768493000470 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 768493000471 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 768493000472 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 768493000473 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 768493000474 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 768493000475 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 768493000476 NAD binding site [chemical binding]; other site 768493000477 substrate binding site [chemical binding]; other site 768493000478 homodimer interface [polypeptide binding]; other site 768493000479 active site 768493000480 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 768493000481 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 768493000482 substrate binding site; other site 768493000483 tetramer interface; other site 768493000484 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768493000485 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493000486 Coenzyme A binding pocket [chemical binding]; other site 768493000487 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 768493000488 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 768493000489 inhibitor-cofactor binding pocket; inhibition site 768493000490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493000491 catalytic residue [active] 768493000492 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 768493000493 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 768493000494 putative common antigen polymerase; Provisional; Region: PRK02975 768493000495 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 768493000496 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 768493000497 putative transport protein YifK; Provisional; Region: PRK10746 768493000498 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 768493000499 HemY protein N-terminus; Region: HemY_N; pfam07219 768493000500 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 768493000501 TPR motif; other site 768493000502 binding surface 768493000503 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 768493000504 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 768493000505 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 768493000506 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 768493000507 active site 768493000508 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 768493000509 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 768493000510 domain interfaces; other site 768493000511 active site 768493000512 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 768493000513 adenylate cyclase; Provisional; Region: cyaA; PRK09450 768493000514 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 768493000515 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 768493000516 putative iron binding site [ion binding]; other site 768493000517 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 768493000518 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 768493000519 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 768493000520 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 768493000521 hypothetical protein; Provisional; Region: PRK10963 768493000522 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 768493000523 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768493000524 active site 768493000525 DNA binding site [nucleotide binding] 768493000526 Int/Topo IB signature motif; other site 768493000527 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 768493000528 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768493000529 motif II; other site 768493000530 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 768493000531 Part of AAA domain; Region: AAA_19; pfam13245 768493000532 Family description; Region: UvrD_C_2; pfam13538 768493000533 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 768493000534 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 768493000535 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 768493000536 oligomer interface [polypeptide binding]; other site 768493000537 Cl binding site [ion binding]; other site 768493000538 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 768493000539 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 768493000540 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 768493000541 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 768493000542 EamA-like transporter family; Region: EamA; cl17759 768493000543 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 768493000544 CoenzymeA binding site [chemical binding]; other site 768493000545 subunit interaction site [polypeptide binding]; other site 768493000546 PHB binding site; other site 768493000547 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 768493000548 dimerization interface [polypeptide binding]; other site 768493000549 substrate binding site [chemical binding]; other site 768493000550 active site 768493000551 calcium binding site [ion binding]; other site 768493000552 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 768493000553 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768493000554 ATP binding site [chemical binding]; other site 768493000555 putative Mg++ binding site [ion binding]; other site 768493000556 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768493000557 nucleotide binding region [chemical binding]; other site 768493000558 ATP-binding site [chemical binding]; other site 768493000559 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 768493000560 HRDC domain; Region: HRDC; pfam00570 768493000561 threonine efflux system; Provisional; Region: PRK10229 768493000562 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 768493000563 lysophospholipase L2; Provisional; Region: PRK10749 768493000564 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 768493000565 putative hydrolase; Provisional; Region: PRK10976 768493000566 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768493000567 active site 768493000568 motif I; other site 768493000569 motif II; other site 768493000570 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768493000571 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 768493000572 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 768493000573 active site 768493000574 catalytic site [active] 768493000575 metal binding site [ion binding]; metal-binding site 768493000576 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 768493000577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493000578 putative substrate translocation pore; other site 768493000579 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 768493000580 hydroxyglutarate oxidase; Provisional; Region: PRK11728 768493000581 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 768493000582 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 768493000583 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 768493000584 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 768493000585 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768493000586 Cysteine-rich domain; Region: CCG; pfam02754 768493000587 Cysteine-rich domain; Region: CCG; pfam02754 768493000588 hypothetical protein; Provisional; Region: PRK11615 768493000589 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493000590 Coenzyme A binding pocket [chemical binding]; other site 768493000591 hypothetical protein; Provisional; Region: PRK11212 768493000592 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 768493000593 CPxP motif; other site 768493000594 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 768493000595 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 768493000596 metal-binding site [ion binding] 768493000597 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768493000598 Soluble P-type ATPase [General function prediction only]; Region: COG4087 768493000599 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 768493000600 active site 768493000601 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 768493000602 Protease inhibitor Inh; Region: Inh; pfam02974 768493000603 Predicted membrane protein [Function unknown]; Region: COG3714 768493000604 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 768493000605 hypothetical protein; Provisional; Region: PRK10910 768493000606 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 768493000607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493000608 S-adenosylmethionine binding site [chemical binding]; other site 768493000609 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 768493000610 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 768493000611 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 768493000612 P loop; other site 768493000613 GTP binding site [chemical binding]; other site 768493000614 cell division protein FtsE; Provisional; Region: PRK10908 768493000615 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768493000616 Walker A/P-loop; other site 768493000617 ATP binding site [chemical binding]; other site 768493000618 Q-loop/lid; other site 768493000619 ABC transporter signature motif; other site 768493000620 Walker B; other site 768493000621 D-loop; other site 768493000622 H-loop/switch region; other site 768493000623 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 768493000624 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 768493000625 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 768493000626 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768493000627 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768493000628 DNA binding residues [nucleotide binding] 768493000629 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 768493000630 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 768493000631 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 768493000632 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 768493000633 dimerization interface [polypeptide binding]; other site 768493000634 ligand binding site [chemical binding]; other site 768493000635 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768493000636 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 768493000637 TM-ABC transporter signature motif; other site 768493000638 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 768493000639 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 768493000640 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 768493000641 TM-ABC transporter signature motif; other site 768493000642 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 768493000643 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 768493000644 Walker A/P-loop; other site 768493000645 ATP binding site [chemical binding]; other site 768493000646 Q-loop/lid; other site 768493000647 ABC transporter signature motif; other site 768493000648 Walker B; other site 768493000649 D-loop; other site 768493000650 H-loop/switch region; other site 768493000651 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 768493000652 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 768493000653 Walker A/P-loop; other site 768493000654 ATP binding site [chemical binding]; other site 768493000655 Q-loop/lid; other site 768493000656 ABC transporter signature motif; other site 768493000657 Walker B; other site 768493000658 D-loop; other site 768493000659 H-loop/switch region; other site 768493000660 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 768493000661 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768493000662 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493000663 homodimer interface [polypeptide binding]; other site 768493000664 catalytic residue [active] 768493000665 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 768493000666 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 768493000667 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 768493000668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493000669 dimer interface [polypeptide binding]; other site 768493000670 conserved gate region; other site 768493000671 putative PBP binding loops; other site 768493000672 ABC-ATPase subunit interface; other site 768493000673 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 768493000674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493000675 dimer interface [polypeptide binding]; other site 768493000676 conserved gate region; other site 768493000677 putative PBP binding loops; other site 768493000678 ABC-ATPase subunit interface; other site 768493000679 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 768493000680 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 768493000681 Walker A/P-loop; other site 768493000682 ATP binding site [chemical binding]; other site 768493000683 Q-loop/lid; other site 768493000684 ABC transporter signature motif; other site 768493000685 Walker B; other site 768493000686 D-loop; other site 768493000687 H-loop/switch region; other site 768493000688 TOBE domain; Region: TOBE_2; pfam08402 768493000689 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 768493000690 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 768493000691 putative active site [active] 768493000692 catalytic site [active] 768493000693 putative metal binding site [ion binding]; other site 768493000694 Predicted permeases [General function prediction only]; Region: COG0679 768493000695 EamA-like transporter family; Region: EamA; pfam00892 768493000696 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 768493000697 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 768493000698 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493000699 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 768493000700 putative dimerization interface [polypeptide binding]; other site 768493000701 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 768493000702 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 768493000703 THF binding site; other site 768493000704 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 768493000705 substrate binding site [chemical binding]; other site 768493000706 THF binding site; other site 768493000707 zinc-binding site [ion binding]; other site 768493000708 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 768493000709 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 768493000710 uridine phosphorylase; Provisional; Region: PRK11178 768493000711 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 768493000712 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 768493000713 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 768493000714 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 768493000715 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 768493000716 DNA recombination protein RmuC; Provisional; Region: PRK10361 768493000717 RmuC family; Region: RmuC; pfam02646 768493000718 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 768493000719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493000720 S-adenosylmethionine binding site [chemical binding]; other site 768493000721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 768493000722 SCP-2 sterol transfer family; Region: SCP2; pfam02036 768493000723 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 768493000724 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 768493000725 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 768493000726 sec-independent translocase; Provisional; Region: PRK01770 768493000727 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 768493000728 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 768493000729 active site 768493000730 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 768493000731 dimer interface [polypeptide binding]; other site 768493000732 active site 768493000733 aspartate-rich active site metal binding site; other site 768493000734 allosteric magnesium binding site [ion binding]; other site 768493000735 Schiff base residues; other site 768493000736 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 768493000737 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 768493000738 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 768493000739 active site pocket [active] 768493000740 oxyanion hole [active] 768493000741 catalytic triad [active] 768493000742 active site nucleophile [active] 768493000743 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 768493000744 FMN reductase; Validated; Region: fre; PRK08051 768493000745 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 768493000746 FAD binding pocket [chemical binding]; other site 768493000747 FAD binding motif [chemical binding]; other site 768493000748 phosphate binding motif [ion binding]; other site 768493000749 beta-alpha-beta structure motif; other site 768493000750 NAD binding pocket [chemical binding]; other site 768493000751 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 768493000752 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 768493000753 dimer interface [polypeptide binding]; other site 768493000754 active site 768493000755 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 768493000756 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768493000757 substrate binding site [chemical binding]; other site 768493000758 oxyanion hole (OAH) forming residues; other site 768493000759 trimer interface [polypeptide binding]; other site 768493000760 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 768493000761 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768493000762 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768493000763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493000764 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768493000765 putative substrate translocation pore; other site 768493000766 proline dipeptidase; Provisional; Region: PRK13607 768493000767 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 768493000768 active site 768493000769 hypothetical protein; Provisional; Region: PRK11568 768493000770 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 768493000771 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 768493000772 potassium transporter; Provisional; Region: PRK10750 768493000773 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 768493000774 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 768493000775 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 768493000776 FAD binding domain; Region: FAD_binding_4; pfam01565 768493000777 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 768493000778 Biotin operon repressor [Transcription]; Region: BirA; COG1654 768493000779 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 768493000780 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 768493000781 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 768493000782 pantothenate kinase; Provisional; Region: PRK05439 768493000783 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 768493000784 ATP-binding site [chemical binding]; other site 768493000785 CoA-binding site [chemical binding]; other site 768493000786 Mg2+-binding site [ion binding]; other site 768493000787 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768493000788 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493000789 Coenzyme A binding pocket [chemical binding]; other site 768493000790 elongation factor Tu; Reviewed; Region: PRK00049 768493000791 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 768493000792 G1 box; other site 768493000793 GEF interaction site [polypeptide binding]; other site 768493000794 GTP/Mg2+ binding site [chemical binding]; other site 768493000795 Switch I region; other site 768493000796 G2 box; other site 768493000797 G3 box; other site 768493000798 Switch II region; other site 768493000799 G4 box; other site 768493000800 G5 box; other site 768493000801 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 768493000802 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 768493000803 Antibiotic Binding Site [chemical binding]; other site 768493000804 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 768493000805 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 768493000806 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 768493000807 putative homodimer interface [polypeptide binding]; other site 768493000808 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 768493000809 heterodimer interface [polypeptide binding]; other site 768493000810 homodimer interface [polypeptide binding]; other site 768493000811 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 768493000812 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 768493000813 23S rRNA interface [nucleotide binding]; other site 768493000814 L7/L12 interface [polypeptide binding]; other site 768493000815 putative thiostrepton binding site; other site 768493000816 L25 interface [polypeptide binding]; other site 768493000817 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 768493000818 mRNA/rRNA interface [nucleotide binding]; other site 768493000819 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 768493000820 23S rRNA interface [nucleotide binding]; other site 768493000821 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 768493000822 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 768493000823 core dimer interface [polypeptide binding]; other site 768493000824 peripheral dimer interface [polypeptide binding]; other site 768493000825 L10 interface [polypeptide binding]; other site 768493000826 L11 interface [polypeptide binding]; other site 768493000827 putative EF-Tu interaction site [polypeptide binding]; other site 768493000828 putative EF-G interaction site [polypeptide binding]; other site 768493000829 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 768493000830 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 768493000831 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 768493000832 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 768493000833 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 768493000834 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 768493000835 RPB3 interaction site [polypeptide binding]; other site 768493000836 RPB1 interaction site [polypeptide binding]; other site 768493000837 RPB11 interaction site [polypeptide binding]; other site 768493000838 RPB10 interaction site [polypeptide binding]; other site 768493000839 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 768493000840 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 768493000841 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 768493000842 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 768493000843 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 768493000844 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 768493000845 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 768493000846 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 768493000847 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 768493000848 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 768493000849 DNA binding site [nucleotide binding] 768493000850 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 768493000851 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768493000852 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493000853 Coenzyme A binding pocket [chemical binding]; other site 768493000854 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 768493000855 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768493000856 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493000857 ATP binding site [chemical binding]; other site 768493000858 Mg2+ binding site [ion binding]; other site 768493000859 G-X-G motif; other site 768493000860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 768493000861 active site 768493000862 phosphorylation site [posttranslational modification] 768493000863 intermolecular recognition site; other site 768493000864 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 768493000865 active site 768493000866 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 768493000867 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768493000868 FeS/SAM binding site; other site 768493000869 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 768493000870 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 768493000871 ThiS interaction site; other site 768493000872 putative active site [active] 768493000873 tetramer interface [polypeptide binding]; other site 768493000874 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 768493000875 thiS-thiF/thiG interaction site; other site 768493000876 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 768493000877 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 768493000878 ATP binding site [chemical binding]; other site 768493000879 substrate interface [chemical binding]; other site 768493000880 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 768493000881 thiamine phosphate binding site [chemical binding]; other site 768493000882 active site 768493000883 pyrophosphate binding site [ion binding]; other site 768493000884 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 768493000885 ThiC-associated domain; Region: ThiC-associated; pfam13667 768493000886 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 768493000887 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 768493000888 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 768493000889 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 768493000890 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 768493000891 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 768493000892 putative NADH binding site [chemical binding]; other site 768493000893 putative active site [active] 768493000894 nudix motif; other site 768493000895 putative metal binding site [ion binding]; other site 768493000896 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 768493000897 substrate binding site [chemical binding]; other site 768493000898 active site 768493000899 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 768493000900 Active_site [active] 768493000901 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 768493000902 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 768493000903 IHF dimer interface [polypeptide binding]; other site 768493000904 IHF - DNA interface [nucleotide binding]; other site 768493000905 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 768493000906 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 768493000907 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 768493000908 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 768493000909 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 768493000910 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 768493000911 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 768493000912 purine monophosphate binding site [chemical binding]; other site 768493000913 dimer interface [polypeptide binding]; other site 768493000914 putative catalytic residues [active] 768493000915 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 768493000916 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 768493000917 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 768493000918 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 768493000919 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 768493000920 Na binding site [ion binding]; other site 768493000921 Predicted membrane protein [Function unknown]; Region: COG3162 768493000922 acetyl-CoA synthetase; Provisional; Region: PRK00174 768493000923 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 768493000924 active site 768493000925 CoA binding site [chemical binding]; other site 768493000926 acyl-activating enzyme (AAE) consensus motif; other site 768493000927 AMP binding site [chemical binding]; other site 768493000928 acetate binding site [chemical binding]; other site 768493000929 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 768493000930 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 768493000931 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 768493000932 active site clefts [active] 768493000933 zinc binding site [ion binding]; other site 768493000934 dimer interface [polypeptide binding]; other site 768493000935 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 768493000936 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 768493000937 Sulfate transporter family; Region: Sulfate_transp; pfam00916 768493000938 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 768493000939 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 768493000940 P-loop; other site 768493000941 Magnesium ion binding site [ion binding]; other site 768493000942 replicative DNA helicase; Region: DnaB; TIGR00665 768493000943 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 768493000944 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 768493000945 Walker A motif; other site 768493000946 ATP binding site [chemical binding]; other site 768493000947 Walker B motif; other site 768493000948 DNA binding loops [nucleotide binding] 768493000949 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 768493000950 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 768493000951 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 768493000952 Helix-turn-helix domain; Region: HTH_36; pfam13730 768493000953 Domain of unknown function (DUF1845); Region: DUF1845; pfam08900 768493000954 DNA topoisomerase III; Provisional; Region: PRK07726 768493000955 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 768493000956 active site 768493000957 putative interdomain interaction site [polypeptide binding]; other site 768493000958 putative metal-binding site [ion binding]; other site 768493000959 putative nucleotide binding site [chemical binding]; other site 768493000960 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 768493000961 domain I; other site 768493000962 DNA binding groove [nucleotide binding] 768493000963 phosphate binding site [ion binding]; other site 768493000964 domain II; other site 768493000965 domain III; other site 768493000966 nucleotide binding site [chemical binding]; other site 768493000967 catalytic site [active] 768493000968 domain IV; other site 768493000969 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 768493000970 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 768493000971 active site 768493000972 iron coordination sites [ion binding]; other site 768493000973 substrate binding pocket [chemical binding]; other site 768493000974 Domain of unknown function (DUF955); Region: DUF955; pfam06114 768493000975 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 768493000976 Part of AAA domain; Region: AAA_19; pfam13245 768493000977 Family description; Region: UvrD_C_2; pfam13538 768493000978 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 768493000979 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 768493000980 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768493000981 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768493000982 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 768493000983 Restriction endonuclease; Region: Mrr_cat; pfam04471 768493000984 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 768493000985 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 768493000986 integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747 768493000987 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 768493000988 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 768493000989 Protein of unknown function (DUF3262); Region: DUF3262; pfam11660 768493000990 Protein of unknown function (DUF2976); Region: DUF2976; cl12739 768493000991 Protein of unknown function (DUF3487); Region: DUF3487; pfam11990 768493000992 Protein of unknown function (DUF2895); Region: DUF2895; pfam11444 768493000993 Protein of unknown function (DUF3438); Region: DUF3438; pfam11920 768493000994 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 768493000995 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 768493000996 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 768493000997 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 768493000998 Protein of unknown function (DUF1525); Region: DUF1525; pfam07511 768493000999 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 768493001000 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 768493001001 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 768493001002 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768493001003 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768493001004 Walker A/P-loop; other site 768493001005 ATP binding site [chemical binding]; other site 768493001006 RES domain; Region: RES; smart00953 768493001007 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 768493001008 Integrase; Region: Integrase_1; pfam12835 768493001009 Protein of unknown function (DUF3085); Region: DUF3085; pfam11284 768493001010 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 768493001011 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 768493001012 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 768493001013 HlyD family secretion protein; Region: HlyD; pfam00529 768493001014 HlyD family secretion protein; Region: HlyD_3; pfam13437 768493001015 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 768493001016 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 768493001017 putative active site [active] 768493001018 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768493001019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768493001020 Walker A/P-loop; other site 768493001021 ATP binding site [chemical binding]; other site 768493001022 Q-loop/lid; other site 768493001023 ABC transporter signature motif; other site 768493001024 Walker B; other site 768493001025 D-loop; other site 768493001026 H-loop/switch region; other site 768493001027 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768493001028 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768493001029 dimer interface [polypeptide binding]; other site 768493001030 phosphorylation site [posttranslational modification] 768493001031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493001032 ATP binding site [chemical binding]; other site 768493001033 Mg2+ binding site [ion binding]; other site 768493001034 G-X-G motif; other site 768493001035 Response regulator receiver domain; Region: Response_reg; pfam00072 768493001036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493001037 active site 768493001038 phosphorylation site [posttranslational modification] 768493001039 intermolecular recognition site; other site 768493001040 dimerization interface [polypeptide binding]; other site 768493001041 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 768493001042 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 768493001043 BetR domain; Region: BetR; pfam08667 768493001044 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 768493001045 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493001046 active site 768493001047 phosphorylation site [posttranslational modification] 768493001048 intermolecular recognition site; other site 768493001049 dimerization interface [polypeptide binding]; other site 768493001050 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 768493001051 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 768493001052 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 768493001053 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 768493001054 active site 768493001055 catalytic residues [active] 768493001056 DNA binding site [nucleotide binding] 768493001057 Int/Topo IB signature motif; other site 768493001058 putative transcriptional regulator; Provisional; Region: PRK11640 768493001059 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768493001060 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 768493001061 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 768493001062 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 768493001063 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 768493001064 DsbD alpha interface [polypeptide binding]; other site 768493001065 catalytic residues [active] 768493001066 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 768493001067 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 768493001068 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 768493001069 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 768493001070 Aspartase; Region: Aspartase; cd01357 768493001071 active sites [active] 768493001072 tetramer interface [polypeptide binding]; other site 768493001073 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 768493001074 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 768493001075 oligomerisation interface [polypeptide binding]; other site 768493001076 mobile loop; other site 768493001077 roof hairpin; other site 768493001078 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 768493001079 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 768493001080 ring oligomerisation interface [polypeptide binding]; other site 768493001081 ATP/Mg binding site [chemical binding]; other site 768493001082 stacking interactions; other site 768493001083 hinge regions; other site 768493001084 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 768493001085 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 768493001086 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768493001087 FeS/SAM binding site; other site 768493001088 elongation factor P; Validated; Region: PRK00529 768493001089 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 768493001090 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 768493001091 RNA binding site [nucleotide binding]; other site 768493001092 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 768493001093 RNA binding site [nucleotide binding]; other site 768493001094 entericidin A; Provisional; Region: PRK09810 768493001095 Predicted small secreted protein [Function unknown]; Region: COG5510 768493001096 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 768493001097 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 768493001098 Iron-sulfur protein interface; other site 768493001099 proximal quinone binding site [chemical binding]; other site 768493001100 C-subunit interface; other site 768493001101 distal quinone binding site; other site 768493001102 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 768493001103 D-subunit interface [polypeptide binding]; other site 768493001104 Iron-sulfur protein interface; other site 768493001105 proximal quinone binding site [chemical binding]; other site 768493001106 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 768493001107 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 768493001108 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 768493001109 L-aspartate oxidase; Provisional; Region: PRK06175 768493001110 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 768493001111 poxB regulator PoxA; Provisional; Region: PRK09350 768493001112 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 768493001113 motif 1; other site 768493001114 dimer interface [polypeptide binding]; other site 768493001115 active site 768493001116 motif 2; other site 768493001117 motif 3; other site 768493001118 putative mechanosensitive channel protein; Provisional; Region: PRK10929 768493001119 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 768493001120 Mechanosensitive ion channel; Region: MS_channel; pfam00924 768493001121 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 768493001122 GTPase RsgA; Reviewed; Region: PRK12288 768493001123 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 768493001124 RNA binding site [nucleotide binding]; other site 768493001125 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 768493001126 GTPase/Zn-binding domain interface [polypeptide binding]; other site 768493001127 GTP/Mg2+ binding site [chemical binding]; other site 768493001128 G4 box; other site 768493001129 G5 box; other site 768493001130 G1 box; other site 768493001131 Switch I region; other site 768493001132 G2 box; other site 768493001133 G3 box; other site 768493001134 Switch II region; other site 768493001135 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 768493001136 catalytic site [active] 768493001137 putative active site [active] 768493001138 putative substrate binding site [chemical binding]; other site 768493001139 dimer interface [polypeptide binding]; other site 768493001140 epoxyqueuosine reductase; Region: TIGR00276 768493001141 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 768493001142 putative carbohydrate kinase; Provisional; Region: PRK10565 768493001143 Uncharacterized conserved protein [Function unknown]; Region: COG0062 768493001144 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 768493001145 putative substrate binding site [chemical binding]; other site 768493001146 putative ATP binding site [chemical binding]; other site 768493001147 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 768493001148 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 768493001149 AMIN domain; Region: AMIN; pfam11741 768493001150 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 768493001151 active site 768493001152 metal binding site [ion binding]; metal-binding site 768493001153 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768493001154 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 768493001155 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493001156 ATP binding site [chemical binding]; other site 768493001157 Mg2+ binding site [ion binding]; other site 768493001158 G-X-G motif; other site 768493001159 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 768493001160 ATP binding site [chemical binding]; other site 768493001161 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 768493001162 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 768493001163 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 768493001164 bacterial Hfq-like; Region: Hfq; cd01716 768493001165 hexamer interface [polypeptide binding]; other site 768493001166 Sm1 motif; other site 768493001167 RNA binding site [nucleotide binding]; other site 768493001168 Sm2 motif; other site 768493001169 GTPase HflX; Provisional; Region: PRK11058 768493001170 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 768493001171 HflX GTPase family; Region: HflX; cd01878 768493001172 G1 box; other site 768493001173 GTP/Mg2+ binding site [chemical binding]; other site 768493001174 Switch I region; other site 768493001175 G2 box; other site 768493001176 G3 box; other site 768493001177 Switch II region; other site 768493001178 G4 box; other site 768493001179 G5 box; other site 768493001180 FtsH protease regulator HflK; Provisional; Region: PRK10930 768493001181 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 768493001182 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 768493001183 FtsH protease regulator HflC; Provisional; Region: PRK11029 768493001184 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 768493001185 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 768493001186 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 768493001187 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 768493001188 GDP-binding site [chemical binding]; other site 768493001189 ACT binding site; other site 768493001190 IMP binding site; other site 768493001191 transcriptional repressor NsrR; Provisional; Region: PRK11014 768493001192 Rrf2 family protein; Region: rrf2_super; TIGR00738 768493001193 exoribonuclease R; Provisional; Region: PRK11642 768493001194 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 768493001195 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 768493001196 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 768493001197 RNB domain; Region: RNB; pfam00773 768493001198 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 768493001199 RNA binding site [nucleotide binding]; other site 768493001200 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 768493001201 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 768493001202 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 768493001203 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 768493001204 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 768493001205 FAD binding site [chemical binding]; other site 768493001206 substrate binding site [chemical binding]; other site 768493001207 catalytic residues [active] 768493001208 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 768493001209 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 768493001210 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 768493001211 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 768493001212 esterase; Provisional; Region: PRK10566 768493001213 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 768493001214 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 768493001215 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 768493001216 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 768493001217 dimer interface [polypeptide binding]; other site 768493001218 ssDNA binding site [nucleotide binding]; other site 768493001219 tetramer (dimer of dimers) interface [polypeptide binding]; other site 768493001220 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 768493001221 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 768493001222 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 768493001223 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 768493001224 Protein of unknown function, DUF488; Region: DUF488; cl01246 768493001225 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 768493001226 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 768493001227 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 768493001228 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 768493001229 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 768493001230 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 768493001231 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 768493001232 Hemerythrin-like domain; Region: Hr-like; cd12108 768493001233 Fe binding site [ion binding]; other site 768493001234 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 768493001235 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 768493001236 active site 768493001237 metal binding site [ion binding]; metal-binding site 768493001238 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 768493001239 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 768493001240 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 768493001241 active site 768493001242 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl17398 768493001243 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 768493001244 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 768493001245 Domain of unknown function DUF21; Region: DUF21; pfam01595 768493001246 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 768493001247 Transporter associated domain; Region: CorC_HlyC; smart01091 768493001248 methionine sulfoxide reductase A; Provisional; Region: PRK00058 768493001249 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 768493001250 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768493001251 Surface antigen; Region: Bac_surface_Ag; pfam01103 768493001252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 768493001253 Family of unknown function (DUF490); Region: DUF490; pfam04357 768493001254 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 768493001255 putative active site pocket [active] 768493001256 dimerization interface [polypeptide binding]; other site 768493001257 putative catalytic residue [active] 768493001258 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 768493001259 dimer interface [polypeptide binding]; other site 768493001260 substrate binding site [chemical binding]; other site 768493001261 metal binding sites [ion binding]; metal-binding site 768493001262 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 768493001263 ligand binding site [chemical binding]; other site 768493001264 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768493001265 dimerization interface [polypeptide binding]; other site 768493001266 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768493001267 dimer interface [polypeptide binding]; other site 768493001268 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 768493001269 putative CheW interface [polypeptide binding]; other site 768493001270 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 768493001271 AMP binding site [chemical binding]; other site 768493001272 metal binding site [ion binding]; metal-binding site 768493001273 active site 768493001274 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 768493001275 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 768493001276 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768493001277 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768493001278 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 768493001279 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 768493001280 arginine repressor; Provisional; Region: PRK05066 768493001281 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 768493001282 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 768493001283 malate dehydrogenase; Provisional; Region: PRK05086 768493001284 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 768493001285 NAD binding site [chemical binding]; other site 768493001286 dimerization interface [polypeptide binding]; other site 768493001287 Substrate binding site [chemical binding]; other site 768493001288 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 768493001289 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 768493001290 Protein of unknown function (DUF447); Region: DUF447; cl17801 768493001291 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 768493001292 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 768493001293 substrate binding pocket [chemical binding]; other site 768493001294 chain length determination region; other site 768493001295 substrate-Mg2+ binding site; other site 768493001296 catalytic residues [active] 768493001297 aspartate-rich region 1; other site 768493001298 active site lid residues [active] 768493001299 aspartate-rich region 2; other site 768493001300 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 768493001301 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 768493001302 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768493001303 EamA-like transporter family; Region: EamA; pfam00892 768493001304 GTPase CgtA; Reviewed; Region: obgE; PRK12298 768493001305 GTP1/OBG; Region: GTP1_OBG; pfam01018 768493001306 Obg GTPase; Region: Obg; cd01898 768493001307 G1 box; other site 768493001308 GTP/Mg2+ binding site [chemical binding]; other site 768493001309 Switch I region; other site 768493001310 G2 box; other site 768493001311 G3 box; other site 768493001312 Switch II region; other site 768493001313 G4 box; other site 768493001314 G5 box; other site 768493001315 sensor protein BasS/PmrB; Provisional; Region: PRK10755 768493001316 HAMP domain; Region: HAMP; pfam00672 768493001317 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768493001318 dimer interface [polypeptide binding]; other site 768493001319 phosphorylation site [posttranslational modification] 768493001320 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493001321 ATP binding site [chemical binding]; other site 768493001322 Mg2+ binding site [ion binding]; other site 768493001323 G-X-G motif; other site 768493001324 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 768493001325 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493001326 active site 768493001327 phosphorylation site [posttranslational modification] 768493001328 intermolecular recognition site; other site 768493001329 dimerization interface [polypeptide binding]; other site 768493001330 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768493001331 DNA binding site [nucleotide binding] 768493001332 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 768493001333 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 768493001334 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 768493001335 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 768493001336 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 768493001337 RNA-binding protein YhbY; Provisional; Region: PRK10343 768493001338 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 768493001339 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493001340 S-adenosylmethionine binding site [chemical binding]; other site 768493001341 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 768493001342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768493001343 Walker A motif; other site 768493001344 ATP binding site [chemical binding]; other site 768493001345 Walker B motif; other site 768493001346 arginine finger; other site 768493001347 Peptidase family M41; Region: Peptidase_M41; pfam01434 768493001348 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 768493001349 dihydropteroate synthase; Region: DHPS; TIGR01496 768493001350 substrate binding pocket [chemical binding]; other site 768493001351 dimer interface [polypeptide binding]; other site 768493001352 inhibitor binding site; inhibition site 768493001353 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 768493001354 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 768493001355 active site 768493001356 substrate binding site [chemical binding]; other site 768493001357 metal binding site [ion binding]; metal-binding site 768493001358 Preprotein translocase SecG subunit; Region: SecG; pfam03840 768493001359 ribosome maturation protein RimP; Reviewed; Region: PRK00092 768493001360 Sm and related proteins; Region: Sm_like; cl00259 768493001361 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 768493001362 putative oligomer interface [polypeptide binding]; other site 768493001363 putative RNA binding site [nucleotide binding]; other site 768493001364 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 768493001365 NusA N-terminal domain; Region: NusA_N; pfam08529 768493001366 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 768493001367 RNA binding site [nucleotide binding]; other site 768493001368 homodimer interface [polypeptide binding]; other site 768493001369 NusA-like KH domain; Region: KH_5; pfam13184 768493001370 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 768493001371 G-X-X-G motif; other site 768493001372 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 768493001373 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 768493001374 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 768493001375 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 768493001376 translation initiation factor IF-2; Region: IF-2; TIGR00487 768493001377 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 768493001378 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 768493001379 G1 box; other site 768493001380 putative GEF interaction site [polypeptide binding]; other site 768493001381 GTP/Mg2+ binding site [chemical binding]; other site 768493001382 Switch I region; other site 768493001383 G2 box; other site 768493001384 G3 box; other site 768493001385 Switch II region; other site 768493001386 G4 box; other site 768493001387 G5 box; other site 768493001388 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 768493001389 Translation-initiation factor 2; Region: IF-2; pfam11987 768493001390 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 768493001391 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 768493001392 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 768493001393 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 768493001394 RNA binding site [nucleotide binding]; other site 768493001395 active site 768493001396 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 768493001397 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 768493001398 16S/18S rRNA binding site [nucleotide binding]; other site 768493001399 S13e-L30e interaction site [polypeptide binding]; other site 768493001400 25S rRNA binding site [nucleotide binding]; other site 768493001401 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 768493001402 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 768493001403 RNase E interface [polypeptide binding]; other site 768493001404 trimer interface [polypeptide binding]; other site 768493001405 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 768493001406 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 768493001407 RNase E interface [polypeptide binding]; other site 768493001408 trimer interface [polypeptide binding]; other site 768493001409 active site 768493001410 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 768493001411 putative nucleic acid binding region [nucleotide binding]; other site 768493001412 G-X-X-G motif; other site 768493001413 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 768493001414 RNA binding site [nucleotide binding]; other site 768493001415 domain interface; other site 768493001416 lipoprotein NlpI; Provisional; Region: PRK11189 768493001417 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768493001418 binding surface 768493001419 TPR motif; other site 768493001420 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 768493001421 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 768493001422 ATP binding site [chemical binding]; other site 768493001423 Mg++ binding site [ion binding]; other site 768493001424 motif III; other site 768493001425 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768493001426 nucleotide binding region [chemical binding]; other site 768493001427 ATP-binding site [chemical binding]; other site 768493001428 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 768493001429 putative RNA binding site [nucleotide binding]; other site 768493001430 putative inner membrane protein; Provisional; Region: PRK11099 768493001431 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 768493001432 CPxP motif; other site 768493001433 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768493001434 non-specific DNA binding site [nucleotide binding]; other site 768493001435 salt bridge; other site 768493001436 sequence-specific DNA binding site [nucleotide binding]; other site 768493001437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493001438 putative substrate translocation pore; other site 768493001439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493001440 hypothetical protein; Provisional; Region: PRK10508 768493001441 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 768493001442 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 768493001443 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 768493001444 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 768493001445 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768493001446 HlyD family secretion protein; Region: HlyD_3; pfam13437 768493001447 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 768493001448 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 768493001449 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 768493001450 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 768493001451 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768493001452 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 768493001453 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 768493001454 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 768493001455 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 768493001456 active site 768493001457 putative protease; Provisional; Region: PRK15447 768493001458 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 768493001459 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 768493001460 Peptidase family U32; Region: Peptidase_U32; pfam01136 768493001461 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 768493001462 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493001463 Coenzyme A binding pocket [chemical binding]; other site 768493001464 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 768493001465 GIY-YIG motif/motif A; other site 768493001466 putative active site [active] 768493001467 putative metal binding site [ion binding]; other site 768493001468 hypothetical protein; Provisional; Region: PRK03467 768493001469 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 768493001470 NADH(P)-binding; Region: NAD_binding_10; pfam13460 768493001471 NAD binding site [chemical binding]; other site 768493001472 active site 768493001473 putative hydrolase; Provisional; Region: PRK02113 768493001474 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 768493001475 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 768493001476 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 768493001477 trimer interface [polypeptide binding]; other site 768493001478 active site 768493001479 substrate binding site [chemical binding]; other site 768493001480 CoA binding site [chemical binding]; other site 768493001481 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 768493001482 AAA domain; Region: AAA_18; pfam13238 768493001483 active site 768493001484 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 768493001485 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 768493001486 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 768493001487 active site 768493001488 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 768493001489 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768493001490 Walker A/P-loop; other site 768493001491 ATP binding site [chemical binding]; other site 768493001492 Q-loop/lid; other site 768493001493 ABC transporter signature motif; other site 768493001494 Walker B; other site 768493001495 D-loop; other site 768493001496 H-loop/switch region; other site 768493001497 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 768493001498 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768493001499 Walker A/P-loop; other site 768493001500 ATP binding site [chemical binding]; other site 768493001501 Q-loop/lid; other site 768493001502 ABC transporter signature motif; other site 768493001503 Walker B; other site 768493001504 D-loop; other site 768493001505 H-loop/switch region; other site 768493001506 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768493001507 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 768493001508 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 768493001509 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845 768493001510 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 768493001511 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 768493001512 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768493001513 DNA-binding site [nucleotide binding]; DNA binding site 768493001514 UTRA domain; Region: UTRA; pfam07702 768493001515 Predicted permease; Region: DUF318; cl17795 768493001516 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 768493001517 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 768493001518 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768493001519 FeS/SAM binding site; other site 768493001520 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 768493001521 ATP cone domain; Region: ATP-cone; pfam03477 768493001522 Class III ribonucleotide reductase; Region: RNR_III; cd01675 768493001523 effector binding site; other site 768493001524 active site 768493001525 Zn binding site [ion binding]; other site 768493001526 glycine loop; other site 768493001527 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493001528 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493001529 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768493001530 putative effector binding pocket; other site 768493001531 dimerization interface [polypeptide binding]; other site 768493001532 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 768493001533 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 768493001534 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 768493001535 Ca binding site [ion binding]; other site 768493001536 active site 768493001537 catalytic site [active] 768493001538 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 768493001539 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 768493001540 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768493001541 active site turn [active] 768493001542 phosphorylation site [posttranslational modification] 768493001543 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768493001544 trehalose repressor; Provisional; Region: treR; PRK09492 768493001545 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768493001546 DNA binding site [nucleotide binding] 768493001547 domain linker motif; other site 768493001548 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 768493001549 dimerization interface [polypeptide binding]; other site 768493001550 ligand binding site [chemical binding]; other site 768493001551 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 768493001552 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 768493001553 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768493001554 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 768493001555 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768493001556 motif II; other site 768493001557 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 768493001558 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 768493001559 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 768493001560 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 768493001561 active site 768493001562 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 768493001563 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 768493001564 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 768493001565 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 768493001566 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 768493001567 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 768493001568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 768493001569 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 768493001570 Uncharacterized conserved protein [Function unknown]; Region: COG2308 768493001571 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 768493001572 homotrimer interaction site [polypeptide binding]; other site 768493001573 putative active site [active] 768493001574 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 768493001575 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 768493001576 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 768493001577 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 768493001578 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 768493001579 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 768493001580 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 768493001581 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 768493001582 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 768493001583 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 768493001584 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 768493001585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 768493001586 RNase E inhibitor protein; Provisional; Region: PRK11191 768493001587 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 768493001588 active site 768493001589 dinuclear metal binding site [ion binding]; other site 768493001590 dimerization interface [polypeptide binding]; other site 768493001591 choline dehydrogenase; Validated; Region: PRK02106 768493001592 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768493001593 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 768493001594 Acyltransferase family; Region: Acyl_transf_3; pfam01757 768493001595 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768493001596 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493001597 Coenzyme A binding pocket [chemical binding]; other site 768493001598 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 768493001599 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 768493001600 HIGH motif; other site 768493001601 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 768493001602 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 768493001603 active site 768493001604 KMSKS motif; other site 768493001605 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 768493001606 tRNA binding surface [nucleotide binding]; other site 768493001607 anticodon binding site; other site 768493001608 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 768493001609 DNA polymerase III subunit chi; Validated; Region: PRK05728 768493001610 multifunctional aminopeptidase A; Provisional; Region: PRK00913 768493001611 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 768493001612 interface (dimer of trimers) [polypeptide binding]; other site 768493001613 Substrate-binding/catalytic site; other site 768493001614 Zn-binding sites [ion binding]; other site 768493001615 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 768493001616 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 768493001617 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 768493001618 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 768493001619 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 768493001620 active site clefts [active] 768493001621 zinc binding site [ion binding]; other site 768493001622 dimer interface [polypeptide binding]; other site 768493001623 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768493001624 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768493001625 non-specific DNA binding site [nucleotide binding]; other site 768493001626 salt bridge; other site 768493001627 sequence-specific DNA binding site [nucleotide binding]; other site 768493001628 HipA N-terminal domain; Region: Couple_hipA; pfam13657 768493001629 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 768493001630 HipA-like N-terminal domain; Region: HipA_N; pfam07805 768493001631 HipA-like C-terminal domain; Region: HipA_C; pfam07804 768493001632 Z1 domain; Region: Z1; pfam10593 768493001633 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 768493001634 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 768493001635 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 768493001636 cofactor binding site; other site 768493001637 DNA binding site [nucleotide binding] 768493001638 substrate interaction site [chemical binding]; other site 768493001639 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 768493001640 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 768493001641 additional DNA contacts [nucleotide binding]; other site 768493001642 mismatch recognition site; other site 768493001643 active site 768493001644 zinc binding site [ion binding]; other site 768493001645 DNA intercalation site [nucleotide binding]; other site 768493001646 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 768493001647 beta-galactosidase; Region: BGL; TIGR03356 768493001648 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 768493001649 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768493001650 active site turn [active] 768493001651 phosphorylation site [posttranslational modification] 768493001652 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 768493001653 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768493001654 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768493001655 DNA binding site [nucleotide binding] 768493001656 domain linker motif; other site 768493001657 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 768493001658 dimerization interface (closed form) [polypeptide binding]; other site 768493001659 ligand binding site [chemical binding]; other site 768493001660 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 768493001661 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 768493001662 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 768493001663 Uncharacterized small protein [Function unknown]; Region: COG2879 768493001664 carbon starvation protein A; Provisional; Region: PRK15015 768493001665 Carbon starvation protein CstA; Region: CstA; pfam02554 768493001666 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 768493001667 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 768493001668 Beta-lactamase; Region: Beta-lactamase; pfam00144 768493001669 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 768493001670 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 768493001671 active site 768493001672 dimer interface [polypeptide binding]; other site 768493001673 non-prolyl cis peptide bond; other site 768493001674 insertion regions; other site 768493001675 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 768493001676 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 768493001677 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493001678 Coenzyme A binding pocket [chemical binding]; other site 768493001679 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 768493001680 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 768493001681 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 768493001682 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768493001683 non-specific DNA binding site [nucleotide binding]; other site 768493001684 salt bridge; other site 768493001685 sequence-specific DNA binding site [nucleotide binding]; other site 768493001686 PQQ-like domain; Region: PQQ_2; pfam13360 768493001687 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 768493001688 putative transporter; Provisional; Region: PRK11043 768493001689 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493001690 putative substrate translocation pore; other site 768493001691 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 768493001692 Cytochrome P450; Region: p450; cl12078 768493001693 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 768493001694 Predicted flavoprotein [General function prediction only]; Region: COG0431 768493001695 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768493001696 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 768493001697 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 768493001698 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 768493001699 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 768493001700 active site 768493001701 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 768493001702 acyl-CoA synthetase; Validated; Region: PRK05850 768493001703 acyl-activating enzyme (AAE) consensus motif; other site 768493001704 active site 768493001705 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 768493001706 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768493001707 thioester reductase domain; Region: Thioester-redct; TIGR01746 768493001708 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 768493001709 putative NAD(P) binding site [chemical binding]; other site 768493001710 active site 768493001711 putative substrate binding site [chemical binding]; other site 768493001712 Condensation domain; Region: Condensation; pfam00668 768493001713 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 768493001714 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 768493001715 acyl-activating enzyme (AAE) consensus motif; other site 768493001716 AMP binding site [chemical binding]; other site 768493001717 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768493001718 Condensation domain; Region: Condensation; pfam00668 768493001719 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 768493001720 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 768493001721 acyl-activating enzyme (AAE) consensus motif; other site 768493001722 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 768493001723 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 768493001724 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 768493001725 AMP binding site [chemical binding]; other site 768493001726 Methyltransferase domain; Region: Methyltransf_23; pfam13489 768493001727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493001728 S-adenosylmethionine binding site [chemical binding]; other site 768493001729 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768493001730 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768493001731 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 768493001732 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493001733 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493001734 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 768493001735 L,D-transpeptidase; Provisional; Region: PRK10260 768493001736 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 768493001737 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 768493001738 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 768493001739 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 768493001740 Gram-negative bacterial tonB protein; Region: TonB; cl10048 768493001741 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 768493001742 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768493001743 N-terminal plug; other site 768493001744 ligand-binding site [chemical binding]; other site 768493001745 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 768493001746 Putative catalytic domain, repeat 1, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_1; cd09106 768493001747 PLD-like domain; Region: PLDc_2; pfam13091 768493001748 putative active site [active] 768493001749 putative catalytic site [active] 768493001750 Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_2; cd09107 768493001751 PLD-like domain; Region: PLDc_2; pfam13091 768493001752 putative active site [active] 768493001753 putative catalytic site [active] 768493001754 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 768493001755 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768493001756 inhibitor-cofactor binding pocket; inhibition site 768493001757 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493001758 catalytic residue [active] 768493001759 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493001760 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493001761 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768493001762 dimerization interface [polypeptide binding]; other site 768493001763 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 768493001764 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 768493001765 active site 768493001766 NAD binding site [chemical binding]; other site 768493001767 metal binding site [ion binding]; metal-binding site 768493001768 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768493001769 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768493001770 DNA binding residues [nucleotide binding] 768493001771 dimerization interface [polypeptide binding]; other site 768493001772 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 768493001773 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 768493001774 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 768493001775 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 768493001776 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 768493001777 PGAP1-like protein; Region: PGAP1; pfam07819 768493001778 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 768493001779 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 768493001780 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 768493001781 active site 768493001782 Zn binding site [ion binding]; other site 768493001783 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768493001784 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768493001785 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768493001786 DNA binding residues [nucleotide binding] 768493001787 dimerization interface [polypeptide binding]; other site 768493001788 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 768493001789 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 768493001790 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 768493001791 classical (c) SDRs; Region: SDR_c; cd05233 768493001792 NAD(P) binding site [chemical binding]; other site 768493001793 active site 768493001794 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 768493001795 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 768493001796 classical (c) SDRs; Region: SDR_c; cd05233 768493001797 NAD(P) binding site [chemical binding]; other site 768493001798 active site 768493001799 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 768493001800 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768493001801 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 768493001802 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 768493001803 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 768493001804 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 768493001805 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 768493001806 NAD binding site [chemical binding]; other site 768493001807 catalytic residues [active] 768493001808 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 768493001809 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 768493001810 tetramer interface [polypeptide binding]; other site 768493001811 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 768493001812 tetramer interface [polypeptide binding]; other site 768493001813 active site 768493001814 metal binding site [ion binding]; metal-binding site 768493001815 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 768493001816 putative substrate binding pocket [chemical binding]; other site 768493001817 trimer interface [polypeptide binding]; other site 768493001818 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 768493001819 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Region: HpaI; TIGR02311 768493001820 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493001821 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 768493001822 putative substrate translocation pore; other site 768493001823 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 768493001824 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768493001825 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493001826 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 768493001827 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 768493001828 Flavin Reductases; Region: FlaRed; cl00801 768493001829 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 768493001830 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 768493001831 Transcriptional regulators [Transcription]; Region: FadR; COG2186 768493001832 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768493001833 DNA-binding site [nucleotide binding]; DNA binding site 768493001834 FCD domain; Region: FCD; pfam07729 768493001835 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 768493001836 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 768493001837 NAD binding site [chemical binding]; other site 768493001838 homotetramer interface [polypeptide binding]; other site 768493001839 homodimer interface [polypeptide binding]; other site 768493001840 active site 768493001841 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 768493001842 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 768493001843 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 768493001844 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 768493001845 putative active site pocket [active] 768493001846 metal binding site [ion binding]; metal-binding site 768493001847 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 768493001848 Amidohydrolase; Region: Amidohydro_2; pfam04909 768493001849 active site 768493001850 short chain dehydrogenase; Provisional; Region: PRK08628 768493001851 classical (c) SDRs; Region: SDR_c; cd05233 768493001852 NAD(P) binding site [chemical binding]; other site 768493001853 active site 768493001854 Domain of unknown function (DUF718); Region: DUF718; pfam05336 768493001855 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 768493001856 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493001857 putative substrate translocation pore; other site 768493001858 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768493001859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493001860 putative substrate translocation pore; other site 768493001861 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493001862 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493001863 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768493001864 putative effector binding pocket; other site 768493001865 dimerization interface [polypeptide binding]; other site 768493001866 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768493001867 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768493001868 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768493001869 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768493001870 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768493001871 metal binding site [ion binding]; metal-binding site 768493001872 active site 768493001873 I-site; other site 768493001874 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 768493001875 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493001876 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493001877 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 768493001878 putative effector binding pocket; other site 768493001879 putative dimerization interface [polypeptide binding]; other site 768493001880 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768493001881 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768493001882 active site 768493001883 catalytic tetrad [active] 768493001884 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 768493001885 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 768493001886 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493001887 S-adenosylmethionine binding site [chemical binding]; other site 768493001888 DNA polymerase III subunit psi; Validated; Region: PRK06856 768493001889 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 768493001890 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493001891 Coenzyme A binding pocket [chemical binding]; other site 768493001892 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768493001893 non-specific DNA binding site [nucleotide binding]; other site 768493001894 salt bridge; other site 768493001895 sequence-specific DNA binding site [nucleotide binding]; other site 768493001896 HipA N-terminal domain; Region: Couple_hipA; pfam13657 768493001897 HipA-like N-terminal domain; Region: HipA_N; pfam07805 768493001898 HipA-like C-terminal domain; Region: HipA_C; pfam07804 768493001899 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 768493001900 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 768493001901 G1 box; other site 768493001902 putative GEF interaction site [polypeptide binding]; other site 768493001903 GTP/Mg2+ binding site [chemical binding]; other site 768493001904 Switch I region; other site 768493001905 G2 box; other site 768493001906 G3 box; other site 768493001907 Switch II region; other site 768493001908 G4 box; other site 768493001909 G5 box; other site 768493001910 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 768493001911 periplasmic protein; Provisional; Region: PRK10568 768493001912 BON domain; Region: BON; pfam04972 768493001913 BON domain; Region: BON; pfam04972 768493001914 CsbD-like; Region: CsbD; cl17424 768493001915 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 768493001916 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 768493001917 active site 768493001918 nucleophile elbow; other site 768493001919 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 768493001920 active site 768493001921 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 768493001922 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 768493001923 Nucleoside recognition; Region: Gate; pfam07670 768493001924 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 768493001925 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 768493001926 intersubunit interface [polypeptide binding]; other site 768493001927 active site 768493001928 catalytic residue [active] 768493001929 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 768493001930 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 768493001931 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 768493001932 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 768493001933 phosphopentomutase; Provisional; Region: PRK05362 768493001934 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 768493001935 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 768493001936 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 768493001937 Bacterial virulence factor haemolysin; Region: SMP_2; cl11479 768493001938 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 768493001939 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 768493001940 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768493001941 motif II; other site 768493001942 DNA repair protein RadA; Provisional; Region: PRK11823 768493001943 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 768493001944 Walker A motif/ATP binding site; other site 768493001945 ATP binding site [chemical binding]; other site 768493001946 Walker B motif; other site 768493001947 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 768493001948 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768493001949 non-specific DNA binding site [nucleotide binding]; other site 768493001950 salt bridge; other site 768493001951 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 768493001952 sequence-specific DNA binding site [nucleotide binding]; other site 768493001953 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768493001954 active site 768493001955 nucleotide binding site [chemical binding]; other site 768493001956 HIGH motif; other site 768493001957 KMSKS motif; other site 768493001958 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 768493001959 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 768493001960 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 768493001961 putative NAD(P) binding site [chemical binding]; other site 768493001962 dimer interface [polypeptide binding]; other site 768493001963 LysR family transcriptional regulator; Provisional; Region: PRK14997 768493001964 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493001965 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768493001966 putative effector binding pocket; other site 768493001967 dimerization interface [polypeptide binding]; other site 768493001968 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 768493001969 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768493001970 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768493001971 ABC transporter; Region: ABC_tran_2; pfam12848 768493001972 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768493001973 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 768493001974 ligand binding site [chemical binding]; other site 768493001975 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 768493001976 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 768493001977 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768493001978 metal binding site [ion binding]; metal-binding site 768493001979 active site 768493001980 I-site; other site 768493001981 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 768493001982 lytic murein transglycosylase; Provisional; Region: PRK11619 768493001983 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768493001984 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768493001985 catalytic residue [active] 768493001986 Trp operon repressor; Provisional; Region: PRK01381 768493001987 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 768493001988 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768493001989 catalytic core [active] 768493001990 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 768493001991 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493001992 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 768493001993 hypothetical protein; Provisional; Region: PRK10756 768493001994 CreA protein; Region: CreA; pfam05981 768493001995 two-component response regulator; Provisional; Region: PRK11173 768493001996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493001997 active site 768493001998 phosphorylation site [posttranslational modification] 768493001999 intermolecular recognition site; other site 768493002000 dimerization interface [polypeptide binding]; other site 768493002001 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768493002002 DNA binding site [nucleotide binding] 768493002003 putative RNA methyltransferase; Provisional; Region: PRK10433 768493002004 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 768493002005 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 768493002006 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 768493002007 putative catalytic residues [active] 768493002008 putative nucleotide binding site [chemical binding]; other site 768493002009 putative aspartate binding site [chemical binding]; other site 768493002010 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 768493002011 dimer interface [polypeptide binding]; other site 768493002012 putative threonine allosteric regulatory site; other site 768493002013 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 768493002014 putative threonine allosteric regulatory site; other site 768493002015 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 768493002016 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 768493002017 homoserine kinase; Provisional; Region: PRK01212 768493002018 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 768493002019 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 768493002020 threonine synthase; Validated; Region: PRK09225 768493002021 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 768493002022 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768493002023 catalytic residue [active] 768493002024 hypothetical protein; Validated; Region: PRK02101 768493002025 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 768493002026 amino acid carrier protein; Region: agcS; TIGR00835 768493002027 transaldolase-like protein; Provisional; Region: PTZ00411 768493002028 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 768493002029 active site 768493002030 dimer interface [polypeptide binding]; other site 768493002031 catalytic residue [active] 768493002032 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 768493002033 MPT binding site; other site 768493002034 trimer interface [polypeptide binding]; other site 768493002035 metabolite-proton symporter; Region: 2A0106; TIGR00883 768493002036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493002037 putative substrate translocation pore; other site 768493002038 hypothetical protein; Provisional; Region: PRK10659 768493002039 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 768493002040 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 768493002041 nucleotide binding site [chemical binding]; other site 768493002042 chaperone protein DnaJ; Provisional; Region: PRK10767 768493002043 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 768493002044 HSP70 interaction site [polypeptide binding]; other site 768493002045 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 768493002046 substrate binding site [polypeptide binding]; other site 768493002047 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 768493002048 Zn binding sites [ion binding]; other site 768493002049 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 768493002050 dimer interface [polypeptide binding]; other site 768493002051 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 768493002052 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 768493002053 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493002054 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 768493002055 putative dimerization interface [polypeptide binding]; other site 768493002056 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 768493002057 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 768493002058 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 768493002059 active site 768493002060 Riboflavin kinase; Region: Flavokinase; smart00904 768493002061 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 768493002062 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768493002063 active site 768493002064 HIGH motif; other site 768493002065 nucleotide binding site [chemical binding]; other site 768493002066 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 768493002067 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 768493002068 active site 768493002069 KMSKS motif; other site 768493002070 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 768493002071 tRNA binding surface [nucleotide binding]; other site 768493002072 anticodon binding site; other site 768493002073 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 768493002074 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 768493002075 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 768493002076 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 768493002077 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 768493002078 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 768493002079 transcriptional regulator; Provisional; Region: PRK10632 768493002080 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493002081 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768493002082 putative effector binding pocket; other site 768493002083 dimerization interface [polypeptide binding]; other site 768493002084 Pyoverdine/dityrosine biosynthesis protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: DIT1; COG3207 768493002085 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 768493002086 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 768493002087 substrate binding pocket [chemical binding]; other site 768493002088 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 768493002089 active site 768493002090 iron coordination sites [ion binding]; other site 768493002091 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 768493002092 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 768493002093 active site 768493002094 TDP-binding site; other site 768493002095 acceptor substrate-binding pocket; other site 768493002096 dihydrodipicolinate reductase; Provisional; Region: PRK00048 768493002097 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 768493002098 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 768493002099 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 768493002100 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 768493002101 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 768493002102 catalytic site [active] 768493002103 subunit interface [polypeptide binding]; other site 768493002104 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 768493002105 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 768493002106 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 768493002107 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 768493002108 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 768493002109 ATP-grasp domain; Region: ATP-grasp_4; cl17255 768493002110 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 768493002111 IMP binding site; other site 768493002112 dimer interface [polypeptide binding]; other site 768493002113 interdomain contacts; other site 768493002114 partial ornithine binding site; other site 768493002115 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 768493002116 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768493002117 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 768493002118 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 768493002119 TrkA-N domain; Region: TrkA_N; pfam02254 768493002120 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 768493002121 Uncharacterized conserved protein [Function unknown]; Region: COG2966 768493002122 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 768493002123 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 768493002124 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 768493002125 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 768493002126 folate binding site [chemical binding]; other site 768493002127 NADP+ binding site [chemical binding]; other site 768493002128 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 768493002129 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 768493002130 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 768493002131 active site 768493002132 metal binding site [ion binding]; metal-binding site 768493002133 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 768493002134 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 768493002135 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 768493002136 S-adenosylmethionine binding site [chemical binding]; other site 768493002137 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 768493002138 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 768493002139 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 768493002140 SurA N-terminal domain; Region: SurA_N; pfam09312 768493002141 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 768493002142 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 768493002143 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 768493002144 OstA-like protein; Region: OstA; pfam03968 768493002145 Organic solvent tolerance protein; Region: OstA_C; pfam04453 768493002146 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 768493002147 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 768493002148 putative metal binding site [ion binding]; other site 768493002149 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 768493002150 HSP70 interaction site [polypeptide binding]; other site 768493002151 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 768493002152 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 768493002153 active site 768493002154 ATP-dependent helicase HepA; Validated; Region: PRK04914 768493002155 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768493002156 ATP binding site [chemical binding]; other site 768493002157 putative Mg++ binding site [ion binding]; other site 768493002158 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768493002159 nucleotide binding region [chemical binding]; other site 768493002160 ATP-binding site [chemical binding]; other site 768493002161 DNA polymerase II; Reviewed; Region: PRK05762 768493002162 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 768493002163 active site 768493002164 catalytic site [active] 768493002165 substrate binding site [chemical binding]; other site 768493002166 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 768493002167 active site 768493002168 metal-binding site 768493002169 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 768493002170 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 768493002171 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 768493002172 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 768493002173 putative valine binding site [chemical binding]; other site 768493002174 dimer interface [polypeptide binding]; other site 768493002175 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 768493002176 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768493002177 PYR/PP interface [polypeptide binding]; other site 768493002178 dimer interface [polypeptide binding]; other site 768493002179 TPP binding site [chemical binding]; other site 768493002180 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768493002181 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 768493002182 TPP-binding site [chemical binding]; other site 768493002183 dimer interface [polypeptide binding]; other site 768493002184 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 768493002185 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768493002186 Walker A/P-loop; other site 768493002187 ATP binding site [chemical binding]; other site 768493002188 Q-loop/lid; other site 768493002189 ABC transporter signature motif; other site 768493002190 Walker B; other site 768493002191 D-loop; other site 768493002192 H-loop/switch region; other site 768493002193 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 768493002194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493002195 putative PBP binding loops; other site 768493002196 ABC-ATPase subunit interface; other site 768493002197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493002198 dimer interface [polypeptide binding]; other site 768493002199 conserved gate region; other site 768493002200 putative PBP binding loops; other site 768493002201 ABC-ATPase subunit interface; other site 768493002202 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 768493002203 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 768493002204 transcriptional regulator SgrR; Provisional; Region: PRK13626 768493002205 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 768493002206 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 768493002207 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493002208 sugar efflux transporter; Region: 2A0120; TIGR00899 768493002209 putative substrate translocation pore; other site 768493002210 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 768493002211 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 768493002212 transmembrane helices; other site 768493002213 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 768493002214 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 768493002215 substrate binding site [chemical binding]; other site 768493002216 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 768493002217 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 768493002218 substrate binding site [chemical binding]; other site 768493002219 ligand binding site [chemical binding]; other site 768493002220 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 768493002221 tartrate dehydrogenase; Region: TTC; TIGR02089 768493002222 2-isopropylmalate synthase; Validated; Region: PRK00915 768493002223 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 768493002224 active site 768493002225 catalytic residues [active] 768493002226 metal binding site [ion binding]; metal-binding site 768493002227 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 768493002228 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 768493002229 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493002230 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 768493002231 putative substrate binding pocket [chemical binding]; other site 768493002232 putative dimerization interface [polypeptide binding]; other site 768493002233 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 768493002234 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 768493002235 acyl-activating enzyme (AAE) consensus motif; other site 768493002236 putative AMP binding site [chemical binding]; other site 768493002237 putative active site [active] 768493002238 putative CoA binding site [chemical binding]; other site 768493002239 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 768493002240 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768493002241 PYR/PP interface [polypeptide binding]; other site 768493002242 dimer interface [polypeptide binding]; other site 768493002243 TPP binding site [chemical binding]; other site 768493002244 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768493002245 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 768493002246 TPP-binding site [chemical binding]; other site 768493002247 dimer interface [polypeptide binding]; other site 768493002248 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 768493002249 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 768493002250 putative valine binding site [chemical binding]; other site 768493002251 dimer interface [polypeptide binding]; other site 768493002252 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 768493002253 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 768493002254 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768493002255 DNA binding site [nucleotide binding] 768493002256 domain linker motif; other site 768493002257 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 768493002258 dimerization interface [polypeptide binding]; other site 768493002259 ligand binding site [chemical binding]; other site 768493002260 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 768493002261 cell division protein MraZ; Reviewed; Region: PRK00326 768493002262 MraZ protein; Region: MraZ; pfam02381 768493002263 MraZ protein; Region: MraZ; pfam02381 768493002264 MraW methylase family; Region: Methyltransf_5; pfam01795 768493002265 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 768493002266 cell division protein FtsL; Provisional; Region: PRK10772 768493002267 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 768493002268 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 768493002269 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 768493002270 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 768493002271 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 768493002272 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768493002273 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768493002274 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 768493002275 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 768493002276 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768493002277 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768493002278 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 768493002279 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 768493002280 Mg++ binding site [ion binding]; other site 768493002281 putative catalytic motif [active] 768493002282 putative substrate binding site [chemical binding]; other site 768493002283 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 768493002284 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768493002285 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768493002286 cell division protein FtsW; Provisional; Region: PRK10774 768493002287 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 768493002288 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 768493002289 active site 768493002290 homodimer interface [polypeptide binding]; other site 768493002291 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 768493002292 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 768493002293 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768493002294 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768493002295 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 768493002296 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 768493002297 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 768493002298 cell division protein FtsQ; Provisional; Region: PRK10775 768493002299 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 768493002300 Cell division protein FtsQ; Region: FtsQ; pfam03799 768493002301 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 768493002302 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768493002303 Cell division protein FtsA; Region: FtsA; pfam14450 768493002304 cell division protein FtsZ; Validated; Region: PRK09330 768493002305 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 768493002306 nucleotide binding site [chemical binding]; other site 768493002307 SulA interaction site; other site 768493002308 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 768493002309 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 768493002310 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4701 768493002311 SecA regulator SecM; Provisional; Region: PRK02943 768493002312 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 768493002313 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 768493002314 SEC-C motif; Region: SEC-C; pfam02810 768493002315 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 768493002316 active site 768493002317 8-oxo-dGMP binding site [chemical binding]; other site 768493002318 nudix motif; other site 768493002319 metal binding site [ion binding]; metal-binding site 768493002320 DNA gyrase inhibitor; Reviewed; Region: PRK00418 768493002321 hypothetical protein; Provisional; Region: PRK05287 768493002322 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 768493002323 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 768493002324 CoA-binding site [chemical binding]; other site 768493002325 ATP-binding [chemical binding]; other site 768493002326 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 768493002327 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 768493002328 active site 768493002329 type IV pilin biogenesis protein; Provisional; Region: PRK10573 768493002330 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 768493002331 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 768493002332 hypothetical protein; Provisional; Region: PRK10436 768493002333 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 768493002334 Walker A motif; other site 768493002335 ATP binding site [chemical binding]; other site 768493002336 Walker B motif; other site 768493002337 putative major pilin subunit; Provisional; Region: PRK10574 768493002338 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 768493002339 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 768493002340 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 768493002341 dimerization interface [polypeptide binding]; other site 768493002342 active site 768493002343 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 768493002344 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 768493002345 amidase catalytic site [active] 768493002346 Zn binding residues [ion binding]; other site 768493002347 substrate binding site [chemical binding]; other site 768493002348 regulatory protein AmpE; Provisional; Region: PRK10987 768493002349 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 768493002350 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768493002351 inhibitor-cofactor binding pocket; inhibition site 768493002352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493002353 catalytic residue [active] 768493002354 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 768493002355 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 768493002356 Cl- selectivity filter; other site 768493002357 Cl- binding residues [ion binding]; other site 768493002358 pore gating glutamate residue; other site 768493002359 dimer interface [polypeptide binding]; other site 768493002360 H+/Cl- coupling transport residue; other site 768493002361 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 768493002362 hypothetical protein; Provisional; Region: PRK10578 768493002363 UPF0126 domain; Region: UPF0126; pfam03458 768493002364 UPF0126 domain; Region: UPF0126; pfam03458 768493002365 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 768493002366 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 768493002367 cobalamin binding residues [chemical binding]; other site 768493002368 putative BtuC binding residues; other site 768493002369 dimer interface [polypeptide binding]; other site 768493002370 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 768493002371 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 768493002372 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 768493002373 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 768493002374 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 768493002375 serine endoprotease; Provisional; Region: PRK10942 768493002376 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 768493002377 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 768493002378 protein binding site [polypeptide binding]; other site 768493002379 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 768493002380 protein binding site [polypeptide binding]; other site 768493002381 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 768493002382 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 768493002383 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768493002384 dimerization interface [polypeptide binding]; other site 768493002385 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768493002386 dimer interface [polypeptide binding]; other site 768493002387 phosphorylation site [posttranslational modification] 768493002388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493002389 ATP binding site [chemical binding]; other site 768493002390 Mg2+ binding site [ion binding]; other site 768493002391 G-X-G motif; other site 768493002392 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 768493002393 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493002394 active site 768493002395 phosphorylation site [posttranslational modification] 768493002396 intermolecular recognition site; other site 768493002397 dimerization interface [polypeptide binding]; other site 768493002398 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 768493002399 putative binding surface; other site 768493002400 active site 768493002401 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 768493002402 HD domain; Region: HD_4; pfam13328 768493002403 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 768493002404 synthetase active site [active] 768493002405 NTP binding site [chemical binding]; other site 768493002406 metal binding site [ion binding]; metal-binding site 768493002407 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 768493002408 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 768493002409 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 768493002410 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 768493002411 homodimer interface [polypeptide binding]; other site 768493002412 metal binding site [ion binding]; metal-binding site 768493002413 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 768493002414 homodimer interface [polypeptide binding]; other site 768493002415 active site 768493002416 putative chemical substrate binding site [chemical binding]; other site 768493002417 metal binding site [ion binding]; metal-binding site 768493002418 CTP synthetase; Validated; Region: pyrG; PRK05380 768493002419 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 768493002420 Catalytic site [active] 768493002421 active site 768493002422 UTP binding site [chemical binding]; other site 768493002423 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 768493002424 active site 768493002425 putative oxyanion hole; other site 768493002426 catalytic triad [active] 768493002427 enolase; Provisional; Region: eno; PRK00077 768493002428 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 768493002429 dimer interface [polypeptide binding]; other site 768493002430 metal binding site [ion binding]; metal-binding site 768493002431 substrate binding pocket [chemical binding]; other site 768493002432 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 768493002433 methionine gamma-lyase; Provisional; Region: PRK07503 768493002434 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 768493002435 homodimer interface [polypeptide binding]; other site 768493002436 substrate-cofactor binding pocket; other site 768493002437 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493002438 catalytic residue [active] 768493002439 putative proline-specific permease; Provisional; Region: proY; PRK10580 768493002440 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 768493002441 active sites [active] 768493002442 tetramer interface [polypeptide binding]; other site 768493002443 urocanate hydratase; Provisional; Region: PRK05414 768493002444 benzoate transport; Region: 2A0115; TIGR00895 768493002445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493002446 putative substrate translocation pore; other site 768493002447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493002448 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 768493002449 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 768493002450 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 768493002451 active site 768493002452 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 768493002453 Flavodoxin; Region: Flavodoxin_1; pfam00258 768493002454 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 768493002455 FAD binding pocket [chemical binding]; other site 768493002456 FAD binding motif [chemical binding]; other site 768493002457 catalytic residues [active] 768493002458 NAD binding pocket [chemical binding]; other site 768493002459 phosphate binding motif [ion binding]; other site 768493002460 beta-alpha-beta structure motif; other site 768493002461 sulfite reductase subunit beta; Provisional; Region: PRK13504 768493002462 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 768493002463 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 768493002464 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 768493002465 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 768493002466 Active Sites [active] 768493002467 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 768493002468 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 768493002469 metal binding site [ion binding]; metal-binding site 768493002470 siroheme synthase; Provisional; Region: cysG; PRK10637 768493002471 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 768493002472 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 768493002473 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 768493002474 active site 768493002475 SAM binding site [chemical binding]; other site 768493002476 homodimer interface [polypeptide binding]; other site 768493002477 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 768493002478 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 768493002479 Active Sites [active] 768493002480 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 768493002481 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 768493002482 CysD dimerization site [polypeptide binding]; other site 768493002483 G1 box; other site 768493002484 putative GEF interaction site [polypeptide binding]; other site 768493002485 GTP/Mg2+ binding site [chemical binding]; other site 768493002486 Switch I region; other site 768493002487 G2 box; other site 768493002488 G3 box; other site 768493002489 Switch II region; other site 768493002490 G4 box; other site 768493002491 G5 box; other site 768493002492 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 768493002493 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 768493002494 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 768493002495 ligand-binding site [chemical binding]; other site 768493002496 hypothetical protein; Provisional; Region: PRK10726 768493002497 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 768493002498 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 768493002499 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 768493002500 substrate binding site; other site 768493002501 dimer interface; other site 768493002502 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 768493002503 homotrimer interaction site [polypeptide binding]; other site 768493002504 zinc binding site [ion binding]; other site 768493002505 CDP-binding sites; other site 768493002506 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 768493002507 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 768493002508 Permutation of conserved domain; other site 768493002509 active site 768493002510 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 768493002511 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 768493002512 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493002513 S-adenosylmethionine binding site [chemical binding]; other site 768493002514 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 768493002515 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768493002516 Peptidase family M23; Region: Peptidase_M23; pfam01551 768493002517 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 768493002518 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 768493002519 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768493002520 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 768493002521 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768493002522 DNA binding residues [nucleotide binding] 768493002523 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 768493002524 MutS domain I; Region: MutS_I; pfam01624 768493002525 MutS domain II; Region: MutS_II; pfam05188 768493002526 MutS domain III; Region: MutS_III; pfam05192 768493002527 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 768493002528 Walker A/P-loop; other site 768493002529 ATP binding site [chemical binding]; other site 768493002530 Q-loop/lid; other site 768493002531 ABC transporter signature motif; other site 768493002532 Walker B; other site 768493002533 D-loop; other site 768493002534 H-loop/switch region; other site 768493002535 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 768493002536 active site 768493002537 P-loop; other site 768493002538 phosphorylation site [posttranslational modification] 768493002539 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 768493002540 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 768493002541 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 768493002542 beta-galactosidase; Region: BGL; TIGR03356 768493002543 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 768493002544 Cupin domain; Region: Cupin_2; pfam07883 768493002545 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493002546 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 768493002547 putative active site [active] 768493002548 YdjC motif; other site 768493002549 Mg binding site [ion binding]; other site 768493002550 putative homodimer interface [polypeptide binding]; other site 768493002551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493002552 putative substrate translocation pore; other site 768493002553 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768493002554 hypothetical protein; Validated; Region: PRK03661 768493002555 recombinase A; Provisional; Region: recA; PRK09354 768493002556 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 768493002557 hexamer interface [polypeptide binding]; other site 768493002558 Walker A motif; other site 768493002559 ATP binding site [chemical binding]; other site 768493002560 Walker B motif; other site 768493002561 recombination regulator RecX; Reviewed; Region: recX; PRK00117 768493002562 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 768493002563 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 768493002564 motif 1; other site 768493002565 active site 768493002566 motif 2; other site 768493002567 motif 3; other site 768493002568 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 768493002569 DHHA1 domain; Region: DHHA1; pfam02272 768493002570 carbon storage regulator; Provisional; Region: PRK01712 768493002571 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 768493002572 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768493002573 motif II; other site 768493002574 Predicted membrane protein [Function unknown]; Region: COG1238 768493002575 glutamate--cysteine ligase; Provisional; Region: PRK02107 768493002576 S-ribosylhomocysteinase; Provisional; Region: PRK02260 768493002577 hypothetical protein; Provisional; Region: PRK11573 768493002578 Domain of unknown function DUF21; Region: DUF21; pfam01595 768493002579 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 768493002580 Transporter associated domain; Region: CorC_HlyC; smart01091 768493002581 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 768493002582 signal recognition particle protein; Provisional; Region: PRK10867 768493002583 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 768493002584 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 768493002585 P loop; other site 768493002586 GTP binding site [chemical binding]; other site 768493002587 Signal peptide binding domain; Region: SRP_SPB; pfam02978 768493002588 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 768493002589 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 768493002590 RimM N-terminal domain; Region: RimM; pfam01782 768493002591 PRC-barrel domain; Region: PRC; pfam05239 768493002592 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 768493002593 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 768493002594 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 768493002595 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 768493002596 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 768493002597 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 768493002598 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 768493002599 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 768493002600 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 768493002601 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 768493002602 major tail tube protein; Provisional; Region: FII; PHA02600 768493002603 major tail sheath protein; Provisional; Region: FI; PHA02560 768493002604 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 768493002605 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 768493002606 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 768493002607 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 768493002608 baseplate assembly protein; Provisional; Region: J; PHA02568 768493002609 baseplate wedge subunit; Provisional; Region: W; PHA02516 768493002610 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 768493002611 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 768493002612 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 768493002613 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 768493002614 catalytic residues [active] 768493002615 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 768493002616 DksA-like zinc finger domain containing protein; Region: PHA00080 768493002617 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 768493002618 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 768493002619 Protein of unknown function, DUF481; Region: DUF481; cl01213 768493002620 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 768493002621 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 768493002622 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 768493002623 Chorismate mutase type II; Region: CM_2; cl00693 768493002624 prephenate dehydrogenase; Validated; Region: PRK08507 768493002625 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 768493002626 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 768493002627 Prephenate dehydratase; Region: PDT; pfam00800 768493002628 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 768493002629 putative L-Phe binding site [chemical binding]; other site 768493002630 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 768493002631 30S subunit binding site; other site 768493002632 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 768493002633 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 768493002634 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768493002635 RNA binding surface [nucleotide binding]; other site 768493002636 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 768493002637 active site 768493002638 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 768493002639 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 768493002640 protein disaggregation chaperone; Provisional; Region: PRK10865 768493002641 Clp amino terminal domain; Region: Clp_N; pfam02861 768493002642 Clp amino terminal domain; Region: Clp_N; pfam02861 768493002643 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768493002644 Walker A motif; other site 768493002645 ATP binding site [chemical binding]; other site 768493002646 Walker B motif; other site 768493002647 arginine finger; other site 768493002648 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768493002649 Walker A motif; other site 768493002650 ATP binding site [chemical binding]; other site 768493002651 Walker B motif; other site 768493002652 arginine finger; other site 768493002653 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 768493002654 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 768493002655 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 768493002656 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 768493002657 putative acyl-acceptor binding pocket; other site 768493002658 Phosphopantetheine attachment site; Region: PP-binding; cl09936 768493002659 acyl carrier protein; Provisional; Region: PRK05350 768493002660 Predicted membrane protein [Function unknown]; Region: COG4648 768493002661 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 768493002662 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 768493002663 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 768493002664 acyl-activating enzyme (AAE) consensus motif; other site 768493002665 acyl-activating enzyme (AAE) consensus motif; other site 768493002666 AMP binding site [chemical binding]; other site 768493002667 active site 768493002668 CoA binding site [chemical binding]; other site 768493002669 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 768493002670 active site 2 [active] 768493002671 active site 1 [active] 768493002672 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 768493002673 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 768493002674 Ligand binding site; other site 768493002675 Putative Catalytic site; other site 768493002676 DXD motif; other site 768493002677 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 768493002678 putative acyl-acceptor binding pocket; other site 768493002679 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 768493002680 active site 768493002681 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 768493002682 Predicted exporter [General function prediction only]; Region: COG4258 768493002683 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 768493002684 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 768493002685 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 768493002686 dimer interface [polypeptide binding]; other site 768493002687 active site 768493002688 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 768493002689 putative active site 1 [active] 768493002690 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 768493002691 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 768493002692 NAD(P) binding site [chemical binding]; other site 768493002693 homotetramer interface [polypeptide binding]; other site 768493002694 homodimer interface [polypeptide binding]; other site 768493002695 active site 768493002696 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 768493002697 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 768493002698 dimer interface [polypeptide binding]; other site 768493002699 active site 768493002700 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768493002701 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768493002702 active site 768493002703 catalytic tetrad [active] 768493002704 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493002705 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493002706 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768493002707 dimerization interface [polypeptide binding]; other site 768493002708 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768493002709 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493002710 putative substrate translocation pore; other site 768493002711 hypothetical protein; Provisional; Region: PRK05421 768493002712 putative catalytic site [active] 768493002713 putative phosphate binding site [ion binding]; other site 768493002714 putative metal binding site [ion binding]; other site 768493002715 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 768493002716 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768493002717 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768493002718 catalytic residue [active] 768493002719 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768493002720 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768493002721 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 768493002722 Methyltransferase domain; Region: Methyltransf_23; pfam13489 768493002723 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493002724 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 768493002725 RNA/DNA hybrid binding site [nucleotide binding]; other site 768493002726 active site 768493002727 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 768493002728 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 768493002729 active site 768493002730 catalytic site [active] 768493002731 substrate binding site [chemical binding]; other site 768493002732 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 768493002733 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 768493002734 Na binding site [ion binding]; other site 768493002735 putative substrate binding site [chemical binding]; other site 768493002736 Transcriptional regulators [Transcription]; Region: FadR; COG2186 768493002737 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768493002738 DNA-binding site [nucleotide binding]; DNA binding site 768493002739 FCD domain; Region: FCD; pfam07729 768493002740 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 768493002741 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 768493002742 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 768493002743 active site 768493002744 catalytic site [active] 768493002745 tetramer interface [polypeptide binding]; other site 768493002746 Helix-turn-helix domain; Region: HTH_37; pfam13744 768493002747 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 768493002748 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 768493002749 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768493002750 N-terminal plug; other site 768493002751 ligand-binding site [chemical binding]; other site 768493002752 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 768493002753 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768493002754 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 768493002755 IucA / IucC family; Region: IucA_IucC; pfam04183 768493002756 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 768493002757 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 768493002758 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 768493002759 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 768493002760 IucA / IucC family; Region: IucA_IucC; pfam04183 768493002761 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 768493002762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493002763 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768493002764 putative substrate translocation pore; other site 768493002765 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 768493002766 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 768493002767 FAD binding pocket [chemical binding]; other site 768493002768 FAD binding motif [chemical binding]; other site 768493002769 phosphate binding motif [ion binding]; other site 768493002770 NAD binding pocket [chemical binding]; other site 768493002771 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 768493002772 amidase; Provisional; Region: PRK09201 768493002773 Amidase; Region: Amidase; cl11426 768493002774 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 768493002775 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 768493002776 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 768493002777 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 768493002778 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768493002779 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 768493002780 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768493002781 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768493002782 substrate binding pocket [chemical binding]; other site 768493002783 membrane-bound complex binding site; other site 768493002784 hinge residues; other site 768493002785 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493002786 dimer interface [polypeptide binding]; other site 768493002787 conserved gate region; other site 768493002788 putative PBP binding loops; other site 768493002789 ABC-ATPase subunit interface; other site 768493002790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 768493002791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493002792 ABC-ATPase subunit interface; other site 768493002793 putative PBP binding loops; other site 768493002794 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 768493002795 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 768493002796 Walker A/P-loop; other site 768493002797 ATP binding site [chemical binding]; other site 768493002798 Q-loop/lid; other site 768493002799 ABC transporter signature motif; other site 768493002800 Walker B; other site 768493002801 D-loop; other site 768493002802 H-loop/switch region; other site 768493002803 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 768493002804 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768493002805 catalytic residue [active] 768493002806 allantoate amidohydrolase; Reviewed; Region: PRK09290 768493002807 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 768493002808 active site 768493002809 metal binding site [ion binding]; metal-binding site 768493002810 dimer interface [polypeptide binding]; other site 768493002811 OHCU decarboxylase; Region: UraD_2; TIGR03180 768493002812 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 768493002813 active site 768493002814 homotetramer interface [polypeptide binding]; other site 768493002815 xanthine permease; Region: pbuX; TIGR03173 768493002816 C-N hydrolase family amidase; Provisional; Region: PRK10438 768493002817 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 768493002818 putative active site [active] 768493002819 catalytic triad [active] 768493002820 dimer interface [polypeptide binding]; other site 768493002821 multimer interface [polypeptide binding]; other site 768493002822 methionine aminotransferase; Validated; Region: PRK09082 768493002823 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768493002824 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493002825 homodimer interface [polypeptide binding]; other site 768493002826 catalytic residue [active] 768493002827 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 768493002828 intersubunit interface [polypeptide binding]; other site 768493002829 active site 768493002830 Zn2+ binding site [ion binding]; other site 768493002831 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 768493002832 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 768493002833 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 768493002834 Cupin domain; Region: Cupin_2; cl17218 768493002835 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 768493002836 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 768493002837 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 768493002838 Hok/gef family; Region: HOK_GEF; pfam01848 768493002839 Hok/gef family; Region: HOK_GEF; pfam01848 768493002840 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 768493002841 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 768493002842 active site 768493002843 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 768493002844 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 768493002845 dimer interface [polypeptide binding]; other site 768493002846 active site 768493002847 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 768493002848 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 768493002849 putative active site [active] 768493002850 putative dimer interface [polypeptide binding]; other site 768493002851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 768493002852 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 768493002853 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768493002854 E3 interaction surface; other site 768493002855 lipoyl attachment site [posttranslational modification]; other site 768493002856 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 768493002857 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 768493002858 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 768493002859 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 768493002860 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 768493002861 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 768493002862 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 768493002863 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768493002864 catalytic loop [active] 768493002865 iron binding site [ion binding]; other site 768493002866 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 768493002867 FAD binding pocket [chemical binding]; other site 768493002868 FAD binding motif [chemical binding]; other site 768493002869 phosphate binding motif [ion binding]; other site 768493002870 beta-alpha-beta structure motif; other site 768493002871 NAD binding pocket [chemical binding]; other site 768493002872 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 768493002873 ApbE family; Region: ApbE; pfam02424 768493002874 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991 768493002875 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 768493002876 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 768493002877 active site 768493002878 catalytic site [active] 768493002879 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 768493002880 active site 768493002881 DNA polymerase IV; Validated; Region: PRK02406 768493002882 DNA binding site [nucleotide binding] 768493002883 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 768493002884 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 768493002885 metal binding site [ion binding]; metal-binding site 768493002886 dimer interface [polypeptide binding]; other site 768493002887 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768493002888 active site 768493002889 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 768493002890 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 768493002891 gamma-glutamyl kinase; Provisional; Region: PRK05429 768493002892 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 768493002893 nucleotide binding site [chemical binding]; other site 768493002894 homotetrameric interface [polypeptide binding]; other site 768493002895 putative phosphate binding site [ion binding]; other site 768493002896 putative allosteric binding site; other site 768493002897 PUA domain; Region: PUA; pfam01472 768493002898 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 768493002899 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 768493002900 putative catalytic cysteine [active] 768493002901 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318 768493002902 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768493002903 Zn2+ binding site [ion binding]; other site 768493002904 Mg2+ binding site [ion binding]; other site 768493002905 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 768493002906 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768493002907 non-specific DNA binding site [nucleotide binding]; other site 768493002908 salt bridge; other site 768493002909 sequence-specific DNA binding site [nucleotide binding]; other site 768493002910 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 768493002911 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 768493002912 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 768493002913 peptide binding site [polypeptide binding]; other site 768493002914 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 768493002915 Condensation domain; Region: Condensation; pfam00668 768493002916 Nonribosomal peptide synthase; Region: NRPS; pfam08415 768493002917 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 768493002918 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 768493002919 acyl-activating enzyme (AAE) consensus motif; other site 768493002920 AMP binding site [chemical binding]; other site 768493002921 Condensation domain; Region: Condensation; pfam00668 768493002922 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 768493002923 Nonribosomal peptide synthase; Region: NRPS; pfam08415 768493002924 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 768493002925 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 768493002926 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768493002927 Condensation domain; Region: Condensation; pfam00668 768493002928 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 768493002929 Uncharacterized conserved protein [Function unknown]; Region: COG3391 768493002930 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 768493002931 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 768493002932 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 768493002933 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 768493002934 catalytic residues [active] 768493002935 hinge region; other site 768493002936 alpha helical domain; other site 768493002937 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 768493002938 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493002939 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 768493002940 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 768493002941 NAD(P) binding site [chemical binding]; other site 768493002942 catalytic residues [active] 768493002943 leucine export protein LeuE; Provisional; Region: PRK10958 768493002944 tellurite resistance protein TehB; Provisional; Region: PRK12335 768493002945 Domain of unknown function (DUF1971); Region: DUF1971; cl17717 768493002946 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493002947 S-adenosylmethionine binding site [chemical binding]; other site 768493002948 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768493002949 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493002950 Coenzyme A binding pocket [chemical binding]; other site 768493002951 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 768493002952 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 768493002953 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 768493002954 C-terminal domain interface [polypeptide binding]; other site 768493002955 GSH binding site (G-site) [chemical binding]; other site 768493002956 dimer interface [polypeptide binding]; other site 768493002957 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 768493002958 N-terminal domain interface [polypeptide binding]; other site 768493002959 dimer interface [polypeptide binding]; other site 768493002960 substrate binding pocket (H-site) [chemical binding]; other site 768493002961 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768493002962 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 768493002963 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493002964 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493002965 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768493002966 dimerization interface [polypeptide binding]; other site 768493002967 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 768493002968 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 768493002969 dimer interface [polypeptide binding]; other site 768493002970 PYR/PP interface [polypeptide binding]; other site 768493002971 TPP binding site [chemical binding]; other site 768493002972 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768493002973 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 768493002974 TPP-binding site [chemical binding]; other site 768493002975 dimer interface [polypeptide binding]; other site 768493002976 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 768493002977 hypothetical protein; Provisional; Region: PRK11667 768493002978 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 768493002979 Domain of unknown function (DUF333); Region: DUF333; pfam03891 768493002980 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 768493002981 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 768493002982 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 768493002983 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 768493002984 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768493002985 active site 768493002986 metal binding site [ion binding]; metal-binding site 768493002987 LysR family transcriptional regulator; Provisional; Region: PRK14997 768493002988 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493002989 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 768493002990 putative effector binding pocket; other site 768493002991 putative dimerization interface [polypeptide binding]; other site 768493002992 Pirin-related protein [General function prediction only]; Region: COG1741 768493002993 Pirin; Region: Pirin; pfam02678 768493002994 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 768493002995 Isochorismatase family; Region: Isochorismatase; pfam00857 768493002996 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 768493002997 catalytic triad [active] 768493002998 dimer interface [polypeptide binding]; other site 768493002999 conserved cis-peptide bond; other site 768493003000 aconitate hydratase, mitochondrial; Region: aconitase_mito; TIGR01340 768493003001 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 768493003002 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768493003003 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768493003004 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 768493003005 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 768493003006 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768493003007 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768493003008 salt bridge; other site 768493003009 non-specific DNA binding site [nucleotide binding]; other site 768493003010 sequence-specific DNA binding site [nucleotide binding]; other site 768493003011 Methyltransferase domain; Region: Methyltransf_31; pfam13847 768493003012 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493003013 S-adenosylmethionine binding site [chemical binding]; other site 768493003014 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 768493003015 amphipathic channel; other site 768493003016 Asn-Pro-Ala signature motifs; other site 768493003017 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 768493003018 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 768493003019 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 768493003020 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 768493003021 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493003022 Coenzyme A binding pocket [chemical binding]; other site 768493003023 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 768493003024 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 768493003025 putative ligand binding residues [chemical binding]; other site 768493003026 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768493003027 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493003028 Coenzyme A binding pocket [chemical binding]; other site 768493003029 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 768493003030 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 768493003031 ADP binding site [chemical binding]; other site 768493003032 magnesium binding site [ion binding]; other site 768493003033 putative shikimate binding site; other site 768493003034 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768493003035 active site 768493003036 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768493003037 catalytic tetrad [active] 768493003038 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768493003039 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768493003040 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768493003041 Helix-turn-helix domain; Region: HTH_18; pfam12833 768493003042 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493003043 SnoaL-like domain; Region: SnoaL_2; pfam12680 768493003044 hypothetical protein; Provisional; Region: PRK10380 768493003045 hypothetical protein; Provisional; Region: PRK10579 768493003046 recombination associated protein; Reviewed; Region: rdgC; PRK00321 768493003047 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768493003048 dimerization interface [polypeptide binding]; other site 768493003049 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768493003050 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768493003051 putative active site [active] 768493003052 heme pocket [chemical binding]; other site 768493003053 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768493003054 dimer interface [polypeptide binding]; other site 768493003055 phosphorylation site [posttranslational modification] 768493003056 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493003057 ATP binding site [chemical binding]; other site 768493003058 Mg2+ binding site [ion binding]; other site 768493003059 G-X-G motif; other site 768493003060 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 768493003061 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493003062 active site 768493003063 phosphorylation site [posttranslational modification] 768493003064 intermolecular recognition site; other site 768493003065 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 768493003066 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768493003067 Walker A/P-loop; other site 768493003068 ATP binding site [chemical binding]; other site 768493003069 Q-loop/lid; other site 768493003070 ABC transporter signature motif; other site 768493003071 Walker B; other site 768493003072 D-loop; other site 768493003073 H-loop/switch region; other site 768493003074 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768493003075 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768493003076 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768493003077 TM-ABC transporter signature motif; other site 768493003078 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 768493003079 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 768493003080 putative ligand binding site [chemical binding]; other site 768493003081 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 768493003082 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 768493003083 intersubunit interface [polypeptide binding]; other site 768493003084 active site 768493003085 zinc binding site [ion binding]; other site 768493003086 Na+ binding site [ion binding]; other site 768493003087 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 768493003088 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768493003089 substrate binding site [chemical binding]; other site 768493003090 ATP binding site [chemical binding]; other site 768493003091 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768493003092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493003093 active site 768493003094 phosphorylation site [posttranslational modification] 768493003095 intermolecular recognition site; other site 768493003096 dimerization interface [polypeptide binding]; other site 768493003097 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768493003098 DNA binding site [nucleotide binding] 768493003099 fructokinase; Reviewed; Region: PRK09557 768493003100 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768493003101 nucleotide binding site [chemical binding]; other site 768493003102 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 768493003103 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 768493003104 putative active site [active] 768493003105 transcriptional antiterminator BglG; Provisional; Region: PRK09772 768493003106 CAT RNA binding domain; Region: CAT_RBD; smart01061 768493003107 PRD domain; Region: PRD; pfam00874 768493003108 PRD domain; Region: PRD; pfam00874 768493003109 ethanolamine permease; Region: 2A0305; TIGR00908 768493003110 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768493003111 AAA domain; Region: AAA_23; pfam13476 768493003112 Walker A/P-loop; other site 768493003113 ATP binding site [chemical binding]; other site 768493003114 Q-loop/lid; other site 768493003115 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768493003116 ABC transporter signature motif; other site 768493003117 Walker B; other site 768493003118 D-loop; other site 768493003119 H-loop/switch region; other site 768493003120 exonuclease subunit SbcD; Provisional; Region: PRK10966 768493003121 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 768493003122 active site 768493003123 metal binding site [ion binding]; metal-binding site 768493003124 DNA binding site [nucleotide binding] 768493003125 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 768493003126 transcriptional regulator PhoB; Provisional; Region: PRK10161 768493003127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493003128 active site 768493003129 phosphorylation site [posttranslational modification] 768493003130 intermolecular recognition site; other site 768493003131 dimerization interface [polypeptide binding]; other site 768493003132 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768493003133 DNA binding site [nucleotide binding] 768493003134 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 768493003135 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 768493003136 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768493003137 putative active site [active] 768493003138 heme pocket [chemical binding]; other site 768493003139 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768493003140 dimer interface [polypeptide binding]; other site 768493003141 phosphorylation site [posttranslational modification] 768493003142 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493003143 ATP binding site [chemical binding]; other site 768493003144 Mg2+ binding site [ion binding]; other site 768493003145 G-X-G motif; other site 768493003146 PBP superfamily domain; Region: PBP_like_2; cl17296 768493003147 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 768493003148 substrate binding site [chemical binding]; other site 768493003149 THF binding site; other site 768493003150 zinc-binding site [ion binding]; other site 768493003151 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 768493003152 putative proline-specific permease; Provisional; Region: proY; PRK10580 768493003153 Spore germination protein; Region: Spore_permease; cl17796 768493003154 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 768493003155 Mechanosensitive ion channel; Region: MS_channel; pfam00924 768493003156 maltodextrin glucosidase; Provisional; Region: PRK10785 768493003157 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 768493003158 homodimer interface [polypeptide binding]; other site 768493003159 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 768493003160 active site 768493003161 homodimer interface [polypeptide binding]; other site 768493003162 catalytic site [active] 768493003163 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 768493003164 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 768493003165 peroxidase; Provisional; Region: PRK15000 768493003166 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 768493003167 dimer interface [polypeptide binding]; other site 768493003168 decamer (pentamer of dimers) interface [polypeptide binding]; other site 768493003169 catalytic triad [active] 768493003170 peroxidatic and resolving cysteines [active] 768493003171 Protein of unknown function, DUF479; Region: DUF479; cl01203 768493003172 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 768493003173 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 768493003174 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 768493003175 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 768493003176 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 768493003177 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 768493003178 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 768493003179 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 768493003180 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 768493003181 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 768493003182 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 768493003183 Protein export membrane protein; Region: SecD_SecF; pfam02355 768493003184 hypothetical protein; Provisional; Region: PRK11530 768493003185 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 768493003186 ATP cone domain; Region: ATP-cone; pfam03477 768493003187 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 768493003188 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 768493003189 catalytic motif [active] 768493003190 Zn binding site [ion binding]; other site 768493003191 RibD C-terminal domain; Region: RibD_C; cl17279 768493003192 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 768493003193 homopentamer interface [polypeptide binding]; other site 768493003194 active site 768493003195 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 768493003196 putative RNA binding site [nucleotide binding]; other site 768493003197 thiamine monophosphate kinase; Provisional; Region: PRK05731 768493003198 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 768493003199 ATP binding site [chemical binding]; other site 768493003200 dimerization interface [polypeptide binding]; other site 768493003201 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 768493003202 tetramer interfaces [polypeptide binding]; other site 768493003203 binuclear metal-binding site [ion binding]; other site 768493003204 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768493003205 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768493003206 active site 768493003207 catalytic tetrad [active] 768493003208 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 768493003209 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 768493003210 TPP-binding site; other site 768493003211 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 768493003212 PYR/PP interface [polypeptide binding]; other site 768493003213 dimer interface [polypeptide binding]; other site 768493003214 TPP binding site [chemical binding]; other site 768493003215 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768493003216 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 768493003217 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 768493003218 substrate binding pocket [chemical binding]; other site 768493003219 chain length determination region; other site 768493003220 substrate-Mg2+ binding site; other site 768493003221 catalytic residues [active] 768493003222 aspartate-rich region 1; other site 768493003223 active site lid residues [active] 768493003224 aspartate-rich region 2; other site 768493003225 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 768493003226 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 768493003227 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 768493003228 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 768493003229 Ligand Binding Site [chemical binding]; other site 768493003230 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 768493003231 active site residue [active] 768493003232 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 768493003233 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 768493003234 conserved cys residue [active] 768493003235 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 768493003236 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 768493003237 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 768493003238 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 768493003239 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 768493003240 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493003241 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768493003242 putative substrate translocation pore; other site 768493003243 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 768493003244 UbiA prenyltransferase family; Region: UbiA; pfam01040 768493003245 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 768493003246 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 768493003247 Subunit I/III interface [polypeptide binding]; other site 768493003248 Subunit III/IV interface [polypeptide binding]; other site 768493003249 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 768493003250 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 768493003251 D-pathway; other site 768493003252 Putative ubiquinol binding site [chemical binding]; other site 768493003253 Low-spin heme (heme b) binding site [chemical binding]; other site 768493003254 Putative water exit pathway; other site 768493003255 Binuclear center (heme o3/CuB) [ion binding]; other site 768493003256 K-pathway; other site 768493003257 Putative proton exit pathway; other site 768493003258 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 768493003259 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 768493003260 Acetyl-coenzyme A transporter 1; Region: Acatn; pfam13000 768493003261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493003262 putative substrate translocation pore; other site 768493003263 hypothetical protein; Provisional; Region: PRK11627 768493003264 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 768493003265 transcriptional regulator BolA; Provisional; Region: PRK11628 768493003266 trigger factor; Provisional; Region: tig; PRK01490 768493003267 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 768493003268 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 768493003269 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 768493003270 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 768493003271 oligomer interface [polypeptide binding]; other site 768493003272 active site residues [active] 768493003273 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 768493003274 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 768493003275 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768493003276 Walker A motif; other site 768493003277 ATP binding site [chemical binding]; other site 768493003278 Walker B motif; other site 768493003279 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 768493003280 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 768493003281 Found in ATP-dependent protease La (LON); Region: LON; smart00464 768493003282 Found in ATP-dependent protease La (LON); Region: LON; smart00464 768493003283 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768493003284 Walker A motif; other site 768493003285 ATP binding site [chemical binding]; other site 768493003286 Walker B motif; other site 768493003287 arginine finger; other site 768493003288 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 768493003289 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 768493003290 IHF dimer interface [polypeptide binding]; other site 768493003291 IHF - DNA interface [nucleotide binding]; other site 768493003292 periplasmic folding chaperone; Provisional; Region: PRK10788 768493003293 SurA N-terminal domain; Region: SurA_N_3; cl07813 768493003294 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 768493003295 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 768493003296 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 768493003297 active site 768493003298 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 768493003299 Ligand Binding Site [chemical binding]; other site 768493003300 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 768493003301 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 768493003302 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 768493003303 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 768493003304 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768493003305 active site 768493003306 motif I; other site 768493003307 motif II; other site 768493003308 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 768493003309 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 768493003310 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 768493003311 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768493003312 catalytic residue [active] 768493003313 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768493003314 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768493003315 putative DNA binding site [nucleotide binding]; other site 768493003316 putative Zn2+ binding site [ion binding]; other site 768493003317 AsnC family; Region: AsnC_trans_reg; pfam01037 768493003318 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 768493003319 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768493003320 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768493003321 Walker A/P-loop; other site 768493003322 ATP binding site [chemical binding]; other site 768493003323 Q-loop/lid; other site 768493003324 ABC transporter signature motif; other site 768493003325 Walker B; other site 768493003326 D-loop; other site 768493003327 H-loop/switch region; other site 768493003328 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 768493003329 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768493003330 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 768493003331 Walker A/P-loop; other site 768493003332 ATP binding site [chemical binding]; other site 768493003333 Q-loop/lid; other site 768493003334 ABC transporter signature motif; other site 768493003335 Walker B; other site 768493003336 D-loop; other site 768493003337 H-loop/switch region; other site 768493003338 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 768493003339 Nitrogen regulatory protein P-II; Region: P-II; smart00938 768493003340 ammonium transporter; Provisional; Region: PRK10666 768493003341 acyl-CoA thioesterase II; Provisional; Region: PRK10526 768493003342 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 768493003343 active site 768493003344 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 768493003345 catalytic triad [active] 768493003346 dimer interface [polypeptide binding]; other site 768493003347 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 768493003348 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 768493003349 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 768493003350 DNA binding site [nucleotide binding] 768493003351 active site 768493003352 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 768493003353 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768493003354 active site 768493003355 DNA binding site [nucleotide binding] 768493003356 Int/Topo IB signature motif; other site 768493003357 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 768493003358 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768493003359 active site 768493003360 DNA binding site [nucleotide binding] 768493003361 Int/Topo IB signature motif; other site 768493003362 Helix-turn-helix domain; Region: HTH_36; pfam13730 768493003363 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 768493003364 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442 768493003365 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768493003366 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 768493003367 Right handed beta helix region; Region: Beta_helix; pfam13229 768493003368 gene expression modulator; Provisional; Region: PRK10945 768493003369 Hha toxicity attenuator; Provisional; Region: PRK10667 768493003370 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 768493003371 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 768493003372 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 768493003373 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768493003374 ABC-ATPase subunit interface; other site 768493003375 dimer interface [polypeptide binding]; other site 768493003376 putative PBP binding regions; other site 768493003377 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 768493003378 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 768493003379 metal binding site [ion binding]; metal-binding site 768493003380 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 768493003381 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 768493003382 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 768493003383 Protein export membrane protein; Region: SecD_SecF; cl14618 768493003384 Protein export membrane protein; Region: SecD_SecF; cl14618 768493003385 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 768493003386 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768493003387 HlyD family secretion protein; Region: HlyD_3; pfam13437 768493003388 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 768493003389 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768493003390 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 768493003391 DsrE/DsrF-like family; Region: DrsE; cl00672 768493003392 hypothetical protein; Provisional; Region: PRK11281 768493003393 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 768493003394 Mechanosensitive ion channel; Region: MS_channel; pfam00924 768493003395 Protein of unknown function (DUF2496); Region: DUF2496; cl11670 768493003396 Primosomal replication protein priB and priC; Region: priB_priC; pfam07445 768493003397 hypothetical protein; Provisional; Region: PRK10527 768493003398 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768493003399 active site 768493003400 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 768493003401 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768493003402 Walker A motif; other site 768493003403 ATP binding site [chemical binding]; other site 768493003404 Walker B motif; other site 768493003405 arginine finger; other site 768493003406 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 768493003407 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 768493003408 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 768493003409 hypothetical protein; Validated; Region: PRK00153 768493003410 recombination protein RecR; Reviewed; Region: recR; PRK00076 768493003411 RecR protein; Region: RecR; pfam02132 768493003412 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 768493003413 putative active site [active] 768493003414 putative metal-binding site [ion binding]; other site 768493003415 tetramer interface [polypeptide binding]; other site 768493003416 heat shock protein 90; Provisional; Region: PRK05218 768493003417 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493003418 ATP binding site [chemical binding]; other site 768493003419 Mg2+ binding site [ion binding]; other site 768493003420 G-X-G motif; other site 768493003421 adenylate kinase; Reviewed; Region: adk; PRK00279 768493003422 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 768493003423 AMP-binding site [chemical binding]; other site 768493003424 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 768493003425 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 768493003426 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 768493003427 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 768493003428 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 768493003429 fructuronate transporter; Provisional; Region: PRK10034; cl15264 768493003430 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 768493003431 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 768493003432 ferrochelatase; Reviewed; Region: hemH; PRK00035 768493003433 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 768493003434 C-terminal domain interface [polypeptide binding]; other site 768493003435 active site 768493003436 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 768493003437 active site 768493003438 N-terminal domain interface [polypeptide binding]; other site 768493003439 inosine/guanosine kinase; Provisional; Region: PRK15074 768493003440 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768493003441 substrate binding site [chemical binding]; other site 768493003442 ATP binding site [chemical binding]; other site 768493003443 putative cation:proton antiport protein; Provisional; Region: PRK10669 768493003444 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 768493003445 TrkA-N domain; Region: TrkA_N; pfam02254 768493003446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493003447 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768493003448 putative substrate translocation pore; other site 768493003449 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 768493003450 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 768493003451 active site 768493003452 metal binding site [ion binding]; metal-binding site 768493003453 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 768493003454 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 768493003455 putative deacylase active site [active] 768493003456 TraB family; Region: TraB; cl12050 768493003457 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 768493003458 metal-binding site [ion binding] 768493003459 copper exporting ATPase; Provisional; Region: copA; PRK10671 768493003460 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 768493003461 metal-binding site [ion binding] 768493003462 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 768493003463 metal-binding site [ion binding] 768493003464 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768493003465 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768493003466 motif II; other site 768493003467 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 768493003468 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 768493003469 DNA binding residues [nucleotide binding] 768493003470 dimer interface [polypeptide binding]; other site 768493003471 copper binding site [ion binding]; other site 768493003472 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 768493003473 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 768493003474 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 768493003475 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 768493003476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493003477 S-adenosylmethionine binding site [chemical binding]; other site 768493003478 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 768493003479 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 768493003480 oxidoreductase; Provisional; Region: PRK08017 768493003481 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 768493003482 NADP binding site [chemical binding]; other site 768493003483 active site 768493003484 steroid binding site; other site 768493003485 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 768493003486 active site 768493003487 catalytic triad [active] 768493003488 oxyanion hole [active] 768493003489 switch loop; other site 768493003490 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 768493003491 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768493003492 Walker A/P-loop; other site 768493003493 ATP binding site [chemical binding]; other site 768493003494 Q-loop/lid; other site 768493003495 ABC transporter signature motif; other site 768493003496 Walker B; other site 768493003497 D-loop; other site 768493003498 H-loop/switch region; other site 768493003499 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 768493003500 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768493003501 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 768493003502 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493003503 putative substrate translocation pore; other site 768493003504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493003505 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 768493003506 ATP-grasp domain; Region: ATP-grasp; pfam02222 768493003507 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 768493003508 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 768493003509 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 768493003510 putative active site [active] 768493003511 putative metal binding site [ion binding]; other site 768493003512 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 768493003513 substrate binding site [chemical binding]; other site 768493003514 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 768493003515 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 768493003516 active site 768493003517 HIGH motif; other site 768493003518 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 768493003519 KMSKS motif; other site 768493003520 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 768493003521 tRNA binding surface [nucleotide binding]; other site 768493003522 anticodon binding site; other site 768493003523 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768493003524 RNA binding surface [nucleotide binding]; other site 768493003525 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 768493003526 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 768493003527 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 768493003528 homodimer interface [polypeptide binding]; other site 768493003529 NADP binding site [chemical binding]; other site 768493003530 substrate binding site [chemical binding]; other site 768493003531 Amidohydrolase; Region: Amidohydro_2; pfam04909 768493003532 active site 768493003533 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768493003534 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768493003535 Fimbrial protein; Region: Fimbrial; cl01416 768493003536 Fimbrial protein; Region: Fimbrial; cl01416 768493003537 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 768493003538 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 768493003539 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 768493003540 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 768493003541 PapC N-terminal domain; Region: PapC_N; pfam13954 768493003542 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 768493003543 PapC C-terminal domain; Region: PapC_C; pfam13953 768493003544 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 768493003545 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 768493003546 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 768493003547 mannosyl binding site [chemical binding]; other site 768493003548 Fimbrial protein; Region: Fimbrial; pfam00419 768493003549 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 768493003550 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 768493003551 Active Sites [active] 768493003552 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 768493003553 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 768493003554 ParB-like nuclease domain; Region: ParB; smart00470 768493003555 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 768493003556 L-lactate permease; Region: Lactate_perm; cl00701 768493003557 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 768493003558 Cysteine-rich domain; Region: CCG; pfam02754 768493003559 Cysteine-rich domain; Region: CCG; pfam02754 768493003560 iron-sulfur cluster-binding protein; Region: TIGR00273 768493003561 HsdM N-terminal domain; Region: HsdM_N; pfam12161 768493003562 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 768493003563 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768493003564 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 768493003565 Uncharacterized conserved protein [Function unknown]; Region: COG1556 768493003566 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 768493003567 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493003568 active site 768493003569 phosphorylation site [posttranslational modification] 768493003570 intermolecular recognition site; other site 768493003571 dimerization interface [polypeptide binding]; other site 768493003572 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768493003573 Walker A motif; other site 768493003574 ATP binding site [chemical binding]; other site 768493003575 Walker B motif; other site 768493003576 arginine finger; other site 768493003577 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768493003578 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768493003579 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768493003580 phosphorylation site [posttranslational modification] 768493003581 dimer interface [polypeptide binding]; other site 768493003582 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493003583 ATP binding site [chemical binding]; other site 768493003584 Mg2+ binding site [ion binding]; other site 768493003585 G-X-G motif; other site 768493003586 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 768493003587 conserved cys residue [active] 768493003588 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768493003589 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493003590 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493003591 3-oxoacyl-acyl carrier protein synthase; Provisional; Region: PTZ00050 768493003592 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 768493003593 active site 768493003594 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 768493003595 acyl-CoA synthetase; Validated; Region: PRK05850 768493003596 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 768493003597 acyl-activating enzyme (AAE) consensus motif; other site 768493003598 active site 768493003599 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 768493003600 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 768493003601 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 768493003602 active site 768493003603 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 768493003604 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768493003605 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 768493003606 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768493003607 inhibitor-cofactor binding pocket; inhibition site 768493003608 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493003609 catalytic residue [active] 768493003610 Condensation domain; Region: Condensation; pfam00668 768493003611 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 768493003612 Arylesterase; Region: Arylesterase; pfam01731 768493003613 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768493003614 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 768493003615 catalytic loop [active] 768493003616 iron binding site [ion binding]; other site 768493003617 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 768493003618 FAD binding pocket [chemical binding]; other site 768493003619 conserved FAD binding motif [chemical binding]; other site 768493003620 phosphate binding motif [ion binding]; other site 768493003621 beta-alpha-beta structure motif; other site 768493003622 NAD binding pocket [chemical binding]; other site 768493003623 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 768493003624 Fatty acid desaturase; Region: FA_desaturase; pfam00487 768493003625 putative di-iron ligands [ion binding]; other site 768493003626 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 768493003627 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768493003628 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 768493003629 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 768493003630 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 768493003631 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 768493003632 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768493003633 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768493003634 active site 768493003635 catalytic tetrad [active] 768493003636 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493003637 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493003638 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 768493003639 putative effector binding pocket; other site 768493003640 putative dimerization interface [polypeptide binding]; other site 768493003641 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 768493003642 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768493003643 MASE1; Region: MASE1; cl17823 768493003644 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768493003645 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768493003646 metal binding site [ion binding]; metal-binding site 768493003647 active site 768493003648 I-site; other site 768493003649 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768493003650 DNA-binding site [nucleotide binding]; DNA binding site 768493003651 RNA-binding motif; other site 768493003652 The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6, and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348 768493003653 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768493003654 putative active site [active] 768493003655 putative metal binding site [ion binding]; other site 768493003656 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 768493003657 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768493003658 Walker A/P-loop; other site 768493003659 ATP binding site [chemical binding]; other site 768493003660 Q-loop/lid; other site 768493003661 ABC transporter signature motif; other site 768493003662 Walker B; other site 768493003663 D-loop; other site 768493003664 H-loop/switch region; other site 768493003665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493003666 dimer interface [polypeptide binding]; other site 768493003667 conserved gate region; other site 768493003668 putative PBP binding loops; other site 768493003669 ABC-ATPase subunit interface; other site 768493003670 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768493003671 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493003672 Coenzyme A binding pocket [chemical binding]; other site 768493003673 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 768493003674 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 768493003675 active site 768493003676 non-prolyl cis peptide bond; other site 768493003677 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 768493003678 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 768493003679 metal binding site [ion binding]; metal-binding site 768493003680 dimer interface [polypeptide binding]; other site 768493003681 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768493003682 DNA-binding site [nucleotide binding]; DNA binding site 768493003683 RNA-binding motif; other site 768493003684 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 768493003685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493003686 putative substrate translocation pore; other site 768493003687 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768493003688 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768493003689 chromosome condensation membrane protein; Provisional; Region: PRK14196 768493003690 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768493003691 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493003692 Coenzyme A binding pocket [chemical binding]; other site 768493003693 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 768493003694 MASE2 domain; Region: MASE2; pfam05230 768493003695 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768493003696 metal binding site [ion binding]; metal-binding site 768493003697 active site 768493003698 I-site; other site 768493003699 twin arginine translocase protein A; Validated; Region: tatE; PRK01614 768493003700 lipoyl synthase; Provisional; Region: PRK05481 768493003701 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768493003702 FeS/SAM binding site; other site 768493003703 lipoate-protein ligase B; Provisional; Region: PRK14342 768493003704 hypothetical protein; Provisional; Region: PRK04998 768493003705 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 768493003706 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 768493003707 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 768493003708 rare lipoprotein A; Provisional; Region: PRK10672 768493003709 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 768493003710 Sporulation related domain; Region: SPOR; cl10051 768493003711 cell wall shape-determining protein; Provisional; Region: PRK10794 768493003712 penicillin-binding protein 2; Provisional; Region: PRK10795 768493003713 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 768493003714 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 768493003715 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 768493003716 Oligomerisation domain; Region: Oligomerisation; cl00519 768493003717 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 768493003718 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 768493003719 active site 768493003720 (T/H)XGH motif; other site 768493003721 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 768493003722 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 768493003723 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 768493003724 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 768493003725 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 768493003726 HIGH motif; other site 768493003727 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 768493003728 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768493003729 active site 768493003730 KMSKS motif; other site 768493003731 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 768493003732 tRNA binding surface [nucleotide binding]; other site 768493003733 hypothetical protein; Provisional; Region: PRK11032 768493003734 Predicted integral membrane metal-binding protein (DUF2296); Region: DUF2296; pfam10058 768493003735 azoreductase; Reviewed; Region: PRK00170 768493003736 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768493003737 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 768493003738 active site 768493003739 tetramer interface [polypeptide binding]; other site 768493003740 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 768493003741 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 768493003742 Walker A/P-loop; other site 768493003743 ATP binding site [chemical binding]; other site 768493003744 Q-loop/lid; other site 768493003745 ABC transporter signature motif; other site 768493003746 Walker B; other site 768493003747 D-loop; other site 768493003748 H-loop/switch region; other site 768493003749 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768493003750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493003751 dimer interface [polypeptide binding]; other site 768493003752 conserved gate region; other site 768493003753 putative PBP binding loops; other site 768493003754 ABC-ATPase subunit interface; other site 768493003755 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768493003756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493003757 dimer interface [polypeptide binding]; other site 768493003758 conserved gate region; other site 768493003759 putative PBP binding loops; other site 768493003760 ABC-ATPase subunit interface; other site 768493003761 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 768493003762 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768493003763 substrate binding pocket [chemical binding]; other site 768493003764 membrane-bound complex binding site; other site 768493003765 hinge residues; other site 768493003766 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 768493003767 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 768493003768 putative active site [active] 768493003769 catalytic triad [active] 768493003770 putative dimer interface [polypeptide binding]; other site 768493003771 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 768493003772 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 768493003773 Transporter associated domain; Region: CorC_HlyC; smart01091 768493003774 metal-binding heat shock protein; Provisional; Region: PRK00016 768493003775 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 768493003776 PhoH-like protein; Region: PhoH; pfam02562 768493003777 hypothetical protein; Provisional; Region: PRK10220 768493003778 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 768493003779 PhnA protein; Region: PhnA; pfam03831 768493003780 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 768493003781 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 768493003782 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768493003783 FeS/SAM binding site; other site 768493003784 TRAM domain; Region: TRAM; pfam01938 768493003785 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 768493003786 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 768493003787 asparagine synthetase B; Provisional; Region: asnB; PRK09431 768493003788 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 768493003789 active site 768493003790 dimer interface [polypeptide binding]; other site 768493003791 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 768493003792 Ligand Binding Site [chemical binding]; other site 768493003793 Molecular Tunnel; other site 768493003794 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 768493003795 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 768493003796 putative active site [active] 768493003797 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 768493003798 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 768493003799 UMP phosphatase; Provisional; Region: PRK10444 768493003800 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768493003801 active site 768493003802 motif I; other site 768493003803 motif II; other site 768493003804 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768493003805 MarR family; Region: MarR; pfam01047 768493003806 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 768493003807 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768493003808 nucleotide binding site [chemical binding]; other site 768493003809 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 768493003810 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 768493003811 active site 768493003812 dimer interface [polypeptide binding]; other site 768493003813 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 768493003814 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 768493003815 active site 768493003816 trimer interface [polypeptide binding]; other site 768493003817 allosteric site; other site 768493003818 active site lid [active] 768493003819 hexamer (dimer of trimers) interface [polypeptide binding]; other site 768493003820 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 768493003821 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768493003822 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768493003823 active site turn [active] 768493003824 phosphorylation site [posttranslational modification] 768493003825 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 768493003826 HPr interaction site; other site 768493003827 glycerol kinase (GK) interaction site [polypeptide binding]; other site 768493003828 active site 768493003829 phosphorylation site [posttranslational modification] 768493003830 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 768493003831 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768493003832 active site 768493003833 HIGH motif; other site 768493003834 nucleotide binding site [chemical binding]; other site 768493003835 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 768493003836 KMSKS motif; other site 768493003837 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 768493003838 outer membrane porin, OprD family; Region: OprD; pfam03573 768493003839 YbfN-like lipoprotein; Region: YbfN; pfam13982 768493003840 Putative carbohydrate binding domain; Region: CHB_HEX; smart01081 768493003841 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 768493003842 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 768493003843 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a...; Region: GH20_Sm-chitobiase-like; cd06569 768493003844 active site 768493003845 C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847 768493003846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493003847 sugar efflux transporter; Region: 2A0120; TIGR00899 768493003848 putative substrate translocation pore; other site 768493003849 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 768493003850 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 768493003851 NAD binding site [chemical binding]; other site 768493003852 homodimer interface [polypeptide binding]; other site 768493003853 active site 768493003854 substrate binding site [chemical binding]; other site 768493003855 TcdB toxin N-terminal helical domain; Region: TcdB_N; pfam12918 768493003856 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 768493003857 ferric uptake regulator; Provisional; Region: fur; PRK09462 768493003858 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 768493003859 metal binding site 2 [ion binding]; metal-binding site 768493003860 putative DNA binding helix; other site 768493003861 metal binding site 1 [ion binding]; metal-binding site 768493003862 dimer interface [polypeptide binding]; other site 768493003863 structural Zn2+ binding site [ion binding]; other site 768493003864 flavodoxin FldA; Validated; Region: PRK09267 768493003865 LexA regulated protein; Provisional; Region: PRK11675 768493003866 acyl-CoA esterase; Provisional; Region: PRK10673 768493003867 PGAP1-like protein; Region: PGAP1; pfam07819 768493003868 replication initiation regulator SeqA; Provisional; Region: PRK11187 768493003869 phosphoglucomutase; Validated; Region: PRK07564 768493003870 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 768493003871 active site 768493003872 substrate binding site [chemical binding]; other site 768493003873 metal binding site [ion binding]; metal-binding site 768493003874 Predicted transcriptional regulators [Transcription]; Region: COG1695 768493003875 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 768493003876 Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977 768493003877 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 768493003878 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493003879 active site 768493003880 phosphorylation site [posttranslational modification] 768493003881 intermolecular recognition site; other site 768493003882 dimerization interface [polypeptide binding]; other site 768493003883 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768493003884 DNA binding site [nucleotide binding] 768493003885 sensor protein KdpD; Provisional; Region: PRK10490 768493003886 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 768493003887 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 768493003888 Ligand Binding Site [chemical binding]; other site 768493003889 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 768493003890 GAF domain; Region: GAF_3; pfam13492 768493003891 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768493003892 dimer interface [polypeptide binding]; other site 768493003893 phosphorylation site [posttranslational modification] 768493003894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493003895 ATP binding site [chemical binding]; other site 768493003896 Mg2+ binding site [ion binding]; other site 768493003897 G-X-G motif; other site 768493003898 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 768493003899 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 768493003900 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768493003901 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 768493003902 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 768493003903 Protein of unknown function (DUF523); Region: DUF523; pfam04463 768493003904 Uncharacterized conserved protein [Function unknown]; Region: COG3272 768493003905 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 768493003906 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 768493003907 DNA photolyase; Region: DNA_photolyase; pfam00875 768493003908 cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776 768493003909 Uncharacterized conserved protein [Function unknown]; Region: COG0327 768493003910 metal-binding protein; Provisional; Region: PRK10799 768493003911 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 768493003912 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 768493003913 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 768493003914 LamB/YcsF family protein; Provisional; Region: PRK05406 768493003915 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 768493003916 putative substrate binding pocket [chemical binding]; other site 768493003917 AC domain interface; other site 768493003918 catalytic triad [active] 768493003919 AB domain interface; other site 768493003920 interchain disulfide; other site 768493003921 endonuclease VIII; Provisional; Region: PRK10445 768493003922 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 768493003923 DNA binding site [nucleotide binding] 768493003924 catalytic residue [active] 768493003925 H2TH interface [polypeptide binding]; other site 768493003926 putative catalytic residues [active] 768493003927 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 768493003928 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 768493003929 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 768493003930 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 768493003931 dimer interface [polypeptide binding]; other site 768493003932 active site 768493003933 citrylCoA binding site [chemical binding]; other site 768493003934 NADH binding [chemical binding]; other site 768493003935 cationic pore residues; other site 768493003936 oxalacetate/citrate binding site [chemical binding]; other site 768493003937 coenzyme A binding site [chemical binding]; other site 768493003938 catalytic triad [active] 768493003939 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 768493003940 Iron-sulfur protein interface; other site 768493003941 proximal quinone binding site [chemical binding]; other site 768493003942 SdhD (CybS) interface [polypeptide binding]; other site 768493003943 proximal heme binding site [chemical binding]; other site 768493003944 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 768493003945 SdhC subunit interface [polypeptide binding]; other site 768493003946 proximal heme binding site [chemical binding]; other site 768493003947 cardiolipin binding site; other site 768493003948 Iron-sulfur protein interface; other site 768493003949 proximal quinone binding site [chemical binding]; other site 768493003950 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 768493003951 L-aspartate oxidase; Provisional; Region: PRK06175 768493003952 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 768493003953 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 768493003954 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 768493003955 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 768493003956 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 768493003957 TPP-binding site [chemical binding]; other site 768493003958 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 768493003959 dimer interface [polypeptide binding]; other site 768493003960 PYR/PP interface [polypeptide binding]; other site 768493003961 TPP binding site [chemical binding]; other site 768493003962 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 768493003963 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768493003964 E3 interaction surface; other site 768493003965 lipoyl attachment site [posttranslational modification]; other site 768493003966 e3 binding domain; Region: E3_binding; pfam02817 768493003967 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 768493003968 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 768493003969 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 768493003970 CoA-ligase; Region: Ligase_CoA; pfam00549 768493003971 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 768493003972 CoA binding domain; Region: CoA_binding; smart00881 768493003973 CoA-ligase; Region: Ligase_CoA; pfam00549 768493003974 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 768493003975 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 768493003976 active site 768493003977 metal binding site [ion binding]; metal-binding site 768493003978 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 768493003979 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 768493003980 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 768493003981 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 768493003982 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 768493003983 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 768493003984 hypothetical protein; Provisional; Region: PRK10588 768493003985 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 768493003986 active site 768493003987 colicin uptake protein TolQ; Provisional; Region: PRK10801 768493003988 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 768493003989 colicin uptake protein TolR; Provisional; Region: PRK11024 768493003990 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 768493003991 TolA C-terminal; Region: TolA; pfam06519 768493003992 translocation protein TolB; Provisional; Region: tolB; PRK03629 768493003993 TolB amino-terminal domain; Region: TolB_N; pfam04052 768493003994 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 768493003995 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 768493003996 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 768493003997 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 768493003998 Serglycin; Region: Serglycin; pfam04360 768493003999 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 768493004000 ligand binding site [chemical binding]; other site 768493004001 tol-pal system protein YbgF; Provisional; Region: PRK10803 768493004002 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768493004003 binding surface 768493004004 TPR motif; other site 768493004005 quinolinate synthetase; Provisional; Region: PRK09375 768493004006 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 768493004007 zinc transporter ZitB; Provisional; Region: PRK03557 768493004008 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768493004009 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768493004010 substrate binding pocket [chemical binding]; other site 768493004011 membrane-bound complex binding site; other site 768493004012 hinge residues; other site 768493004013 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768493004014 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768493004015 substrate binding pocket [chemical binding]; other site 768493004016 membrane-bound complex binding site; other site 768493004017 hinge residues; other site 768493004018 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768493004019 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768493004020 dimer interface [polypeptide binding]; other site 768493004021 phosphorylation site [posttranslational modification] 768493004022 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493004023 ATP binding site [chemical binding]; other site 768493004024 Mg2+ binding site [ion binding]; other site 768493004025 G-X-G motif; other site 768493004026 Response regulator receiver domain; Region: Response_reg; pfam00072 768493004027 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493004028 active site 768493004029 phosphorylation site [posttranslational modification] 768493004030 intermolecular recognition site; other site 768493004031 dimerization interface [polypeptide binding]; other site 768493004032 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 768493004033 putative binding surface; other site 768493004034 active site 768493004035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493004036 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768493004037 active site 768493004038 phosphorylation site [posttranslational modification] 768493004039 intermolecular recognition site; other site 768493004040 dimerization interface [polypeptide binding]; other site 768493004041 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768493004042 DNA binding residues [nucleotide binding] 768493004043 dimerization interface [polypeptide binding]; other site 768493004044 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 768493004045 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 768493004046 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768493004047 catalytic core [active] 768493004048 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768493004049 psiF repeat; Region: PsiF_repeat; pfam07769 768493004050 psiF repeat; Region: PsiF_repeat; pfam07769 768493004051 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 768493004052 active site 768493004053 catalytic residues [active] 768493004054 galactokinase; Provisional; Region: PRK05101 768493004055 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 768493004056 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 768493004057 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 768493004058 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 768493004059 dimer interface [polypeptide binding]; other site 768493004060 active site 768493004061 CAAX protease self-immunity; Region: Abi; pfam02517 768493004062 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 768493004063 Isochorismatase family; Region: Isochorismatase; pfam00857 768493004064 catalytic triad [active] 768493004065 conserved cis-peptide bond; other site 768493004066 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 768493004067 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768493004068 Walker A/P-loop; other site 768493004069 ATP binding site [chemical binding]; other site 768493004070 Q-loop/lid; other site 768493004071 ABC transporter signature motif; other site 768493004072 Walker B; other site 768493004073 D-loop; other site 768493004074 H-loop/switch region; other site 768493004075 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768493004076 Walker A/P-loop; other site 768493004077 ATP binding site [chemical binding]; other site 768493004078 Q-loop/lid; other site 768493004079 ABC transporter signature motif; other site 768493004080 Walker B; other site 768493004081 D-loop; other site 768493004082 H-loop/switch region; other site 768493004083 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 768493004084 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 768493004085 molybdenum-pterin binding domain; Region: Mop; TIGR00638 768493004086 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 768493004087 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 768493004088 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 768493004089 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 768493004090 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 768493004091 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493004092 dimer interface [polypeptide binding]; other site 768493004093 conserved gate region; other site 768493004094 putative PBP binding loops; other site 768493004095 ABC-ATPase subunit interface; other site 768493004096 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 768493004097 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768493004098 Walker A/P-loop; other site 768493004099 ATP binding site [chemical binding]; other site 768493004100 Q-loop/lid; other site 768493004101 ABC transporter signature motif; other site 768493004102 Walker B; other site 768493004103 D-loop; other site 768493004104 H-loop/switch region; other site 768493004105 molybdenum-pterin binding domain; Region: Mop; TIGR00638 768493004106 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 768493004107 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768493004108 active site 768493004109 motif I; other site 768493004110 motif II; other site 768493004111 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768493004112 6-phosphogluconolactonase; Provisional; Region: PRK11028 768493004113 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 768493004114 substrate binding site [chemical binding]; other site 768493004115 Uncharacterized conserved protein [Function unknown]; Region: COG3339 768493004116 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 768493004117 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768493004118 inhibitor-cofactor binding pocket; inhibition site 768493004119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493004120 catalytic residue [active] 768493004121 biotin synthase; Provisional; Region: PRK15108 768493004122 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768493004123 FeS/SAM binding site; other site 768493004124 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 768493004125 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 768493004126 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 768493004127 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768493004128 catalytic residue [active] 768493004129 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 768493004130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493004131 S-adenosylmethionine binding site [chemical binding]; other site 768493004132 AAA domain; Region: AAA_26; pfam13500 768493004133 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 768493004134 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 768493004135 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 768493004136 Walker A/P-loop; other site 768493004137 ATP binding site [chemical binding]; other site 768493004138 Q-loop/lid; other site 768493004139 ABC transporter signature motif; other site 768493004140 Walker B; other site 768493004141 D-loop; other site 768493004142 H-loop/switch region; other site 768493004143 excinuclease ABC subunit B; Provisional; Region: PRK05298 768493004144 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768493004145 ATP binding site [chemical binding]; other site 768493004146 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768493004147 nucleotide binding region [chemical binding]; other site 768493004148 ATP-binding site [chemical binding]; other site 768493004149 Ultra-violet resistance protein B; Region: UvrB; pfam12344 768493004150 UvrB/uvrC motif; Region: UVR; pfam02151 768493004151 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 768493004152 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 768493004153 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 768493004154 phosphate binding site [ion binding]; other site 768493004155 putative substrate binding pocket [chemical binding]; other site 768493004156 dimer interface [polypeptide binding]; other site 768493004157 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 768493004158 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768493004159 FeS/SAM binding site; other site 768493004160 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 768493004161 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 768493004162 MPT binding site; other site 768493004163 trimer interface [polypeptide binding]; other site 768493004164 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 768493004165 trimer interface [polypeptide binding]; other site 768493004166 dimer interface [polypeptide binding]; other site 768493004167 putative active site [active] 768493004168 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 768493004169 MoaE interaction surface [polypeptide binding]; other site 768493004170 MoeB interaction surface [polypeptide binding]; other site 768493004171 thiocarboxylated glycine; other site 768493004172 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 768493004173 MoaE homodimer interface [polypeptide binding]; other site 768493004174 MoaD interaction [polypeptide binding]; other site 768493004175 active site residues [active] 768493004176 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 768493004177 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 768493004178 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 768493004179 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 768493004180 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 768493004181 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 768493004182 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 768493004183 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 768493004184 Walker A/P-loop; other site 768493004185 ATP binding site [chemical binding]; other site 768493004186 Q-loop/lid; other site 768493004187 ABC transporter signature motif; other site 768493004188 Walker B; other site 768493004189 D-loop; other site 768493004190 H-loop/switch region; other site 768493004191 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 768493004192 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 768493004193 Walker A/P-loop; other site 768493004194 ATP binding site [chemical binding]; other site 768493004195 Q-loop/lid; other site 768493004196 ABC transporter signature motif; other site 768493004197 Walker B; other site 768493004198 D-loop; other site 768493004199 H-loop/switch region; other site 768493004200 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 768493004201 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768493004202 HlyD family secretion protein; Region: HlyD_3; pfam13437 768493004203 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 768493004204 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768493004205 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 768493004206 helicase 45; Provisional; Region: PTZ00424 768493004207 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 768493004208 ATP binding site [chemical binding]; other site 768493004209 Mg++ binding site [ion binding]; other site 768493004210 motif III; other site 768493004211 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768493004212 nucleotide binding region [chemical binding]; other site 768493004213 ATP-binding site [chemical binding]; other site 768493004214 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 768493004215 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 768493004216 dimerization interface [polypeptide binding]; other site 768493004217 NAD binding site [chemical binding]; other site 768493004218 ligand binding site [chemical binding]; other site 768493004219 catalytic site [active] 768493004220 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 768493004221 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 768493004222 FMN binding site [chemical binding]; other site 768493004223 active site 768493004224 catalytic residues [active] 768493004225 substrate binding site [chemical binding]; other site 768493004226 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 768493004227 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493004228 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493004229 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768493004230 dimerization interface [polypeptide binding]; other site 768493004231 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 768493004232 HD domain; Region: HD_4; pfam13328 768493004233 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 768493004234 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 768493004235 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 768493004236 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768493004237 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493004238 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 768493004239 dimerization interface [polypeptide binding]; other site 768493004240 substrate binding pocket [chemical binding]; other site 768493004241 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 768493004242 L-asparagine permease; Provisional; Region: PRK15049 768493004243 Predicted membrane protein [Function unknown]; Region: COG4125 768493004244 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 768493004245 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 768493004246 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493004247 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493004248 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768493004249 dimerization interface [polypeptide binding]; other site 768493004250 LysE type translocator; Region: LysE; cl00565 768493004251 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 768493004252 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 768493004253 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 768493004254 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 768493004255 conserved cys residue [active] 768493004256 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 768493004257 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 768493004258 conserved cys residue [active] 768493004259 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493004260 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493004261 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 768493004262 NAD binding site [chemical binding]; other site 768493004263 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 768493004264 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 768493004265 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493004266 Coenzyme A binding pocket [chemical binding]; other site 768493004267 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 768493004268 dimer interface [polypeptide binding]; other site 768493004269 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768493004270 Protein of unknown function (DUF808); Region: DUF808; pfam05661 768493004271 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 768493004272 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493004273 Coenzyme A binding pocket [chemical binding]; other site 768493004274 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768493004275 EamA-like transporter family; Region: EamA; pfam00892 768493004276 EamA-like transporter family; Region: EamA; pfam00892 768493004277 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493004278 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493004279 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768493004280 dimerization interface [polypeptide binding]; other site 768493004281 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 768493004282 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 768493004283 DNA binding residues [nucleotide binding] 768493004284 putative dimer interface [polypeptide binding]; other site 768493004285 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 768493004286 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 768493004287 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 768493004288 lipoprotein, YaeC family; Region: TIGR00363 768493004289 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 768493004290 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493004291 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768493004292 Coenzyme A binding pocket [chemical binding]; other site 768493004293 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 768493004294 putative trimer interface [polypeptide binding]; other site 768493004295 putative active site [active] 768493004296 putative substrate binding site [chemical binding]; other site 768493004297 putative CoA binding site [chemical binding]; other site 768493004298 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 768493004299 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 768493004300 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 768493004301 NAD(P) binding site [chemical binding]; other site 768493004302 catalytic residues [active] 768493004303 D-lactate dehydrogenase; Provisional; Region: PRK11183 768493004304 FAD binding domain; Region: FAD_binding_4; pfam01565 768493004305 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 768493004306 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 768493004307 active site 768493004308 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 768493004309 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 768493004310 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 768493004311 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 768493004312 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 768493004313 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768493004314 substrate binding pocket [chemical binding]; other site 768493004315 membrane-bound complex binding site; other site 768493004316 hinge residues; other site 768493004317 putative aminotransferase; Provisional; Region: PRK12414 768493004318 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768493004319 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493004320 homodimer interface [polypeptide binding]; other site 768493004321 catalytic residue [active] 768493004322 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768493004323 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493004324 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 768493004325 dimerization interface [polypeptide binding]; other site 768493004326 substrate binding pocket [chemical binding]; other site 768493004327 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 768493004328 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 768493004329 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 768493004330 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 768493004331 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768493004332 DNA-binding site [nucleotide binding]; DNA binding site 768493004333 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 768493004334 Uncharacterized protein conserved in archaea (DUF2099); Region: DUF2099; cl01645 768493004335 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 768493004336 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 768493004337 putative ligand binding residues [chemical binding]; other site 768493004338 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 768493004339 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768493004340 ABC-ATPase subunit interface; other site 768493004341 dimer interface [polypeptide binding]; other site 768493004342 putative PBP binding regions; other site 768493004343 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 768493004344 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768493004345 Walker A/P-loop; other site 768493004346 ATP binding site [chemical binding]; other site 768493004347 Q-loop/lid; other site 768493004348 ABC transporter signature motif; other site 768493004349 Walker B; other site 768493004350 D-loop; other site 768493004351 H-loop/switch region; other site 768493004352 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 768493004353 molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537 768493004354 ParA-like protein; Provisional; Region: PHA02518 768493004355 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 768493004356 P-loop; other site 768493004357 Magnesium ion binding site [ion binding]; other site 768493004358 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 768493004359 active site 768493004360 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493004361 Coenzyme A binding pocket [chemical binding]; other site 768493004362 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493004363 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493004364 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 768493004365 putative effector binding pocket; other site 768493004366 putative dimerization interface [polypeptide binding]; other site 768493004367 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768493004368 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 768493004369 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 768493004370 putative N- and C-terminal domain interface [polypeptide binding]; other site 768493004371 putative active site [active] 768493004372 putative MgATP binding site [chemical binding]; other site 768493004373 catalytic site [active] 768493004374 metal binding site [ion binding]; metal-binding site 768493004375 putative carbohydrate binding site [chemical binding]; other site 768493004376 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 768493004377 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 768493004378 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768493004379 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493004380 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768493004381 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493004382 Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718 768493004383 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 768493004384 ATP binding site [chemical binding]; other site 768493004385 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 768493004386 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 768493004387 active site 768493004388 Na/Ca binding site [ion binding]; other site 768493004389 catalytic site [active] 768493004390 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4380 768493004391 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 768493004392 Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462 768493004393 diaminopimelate epimerase; Provisional; Region: PRK13577 768493004394 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 768493004395 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 768493004396 putative transposase OrfB; Reviewed; Region: PHA02517 768493004397 Integrase core domain; Region: rve; pfam00665 768493004398 Integrase core domain; Region: rve_3; pfam13683 768493004399 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 768493004400 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 768493004401 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768493004402 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768493004403 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 768493004404 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 768493004405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493004406 dimer interface [polypeptide binding]; other site 768493004407 conserved gate region; other site 768493004408 putative PBP binding loops; other site 768493004409 ABC-ATPase subunit interface; other site 768493004410 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 768493004411 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 768493004412 Walker A/P-loop; other site 768493004413 ATP binding site [chemical binding]; other site 768493004414 Q-loop/lid; other site 768493004415 ABC transporter signature motif; other site 768493004416 Walker B; other site 768493004417 D-loop; other site 768493004418 H-loop/switch region; other site 768493004419 NIL domain; Region: NIL; pfam09383 768493004420 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768493004421 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493004422 Coenzyme A binding pocket [chemical binding]; other site 768493004423 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493004424 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493004425 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 768493004426 putative effector binding pocket; other site 768493004427 putative dimerization interface [polypeptide binding]; other site 768493004428 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 768493004429 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 768493004430 NADP binding site [chemical binding]; other site 768493004431 dimer interface [polypeptide binding]; other site 768493004432 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 768493004433 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 768493004434 Isochorismatase family; Region: Isochorismatase; pfam00857 768493004435 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 768493004436 catalytic triad [active] 768493004437 conserved cis-peptide bond; other site 768493004438 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768493004439 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 768493004440 NAD(P) binding site [chemical binding]; other site 768493004441 active site 768493004442 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 768493004443 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493004444 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 768493004445 dimerization interface [polypeptide binding]; other site 768493004446 substrate binding pocket [chemical binding]; other site 768493004447 Predicted transcriptional regulator [Transcription]; Region: COG2378 768493004448 HTH domain; Region: HTH_11; pfam08279 768493004449 WYL domain; Region: WYL; pfam13280 768493004450 D-galactonate transporter; Region: 2A0114; TIGR00893 768493004451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493004452 putative substrate translocation pore; other site 768493004453 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768493004454 DNA-binding site [nucleotide binding]; DNA binding site 768493004455 Transcriptional regulators [Transcription]; Region: GntR; COG1802 768493004456 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 768493004457 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 768493004458 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 768493004459 putative NAD(P) binding site [chemical binding]; other site 768493004460 catalytic Zn binding site [ion binding]; other site 768493004461 structural Zn binding site [ion binding]; other site 768493004462 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 768493004463 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 768493004464 Walker A/P-loop; other site 768493004465 ATP binding site [chemical binding]; other site 768493004466 Q-loop/lid; other site 768493004467 ABC transporter signature motif; other site 768493004468 Walker B; other site 768493004469 D-loop; other site 768493004470 H-loop/switch region; other site 768493004471 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 768493004472 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 768493004473 substrate binding pocket [chemical binding]; other site 768493004474 membrane-bound complex binding site; other site 768493004475 hinge residues; other site 768493004476 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 768493004477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493004478 dimer interface [polypeptide binding]; other site 768493004479 conserved gate region; other site 768493004480 putative PBP binding loops; other site 768493004481 ABC-ATPase subunit interface; other site 768493004482 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 768493004483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493004484 dimer interface [polypeptide binding]; other site 768493004485 conserved gate region; other site 768493004486 putative PBP binding loops; other site 768493004487 ABC-ATPase subunit interface; other site 768493004488 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 768493004489 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 768493004490 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 768493004491 allophanate hydrolase; Provisional; Region: PRK08186 768493004492 Amidase; Region: Amidase; cl11426 768493004493 urea carboxylase; Region: urea_carbox; TIGR02712 768493004494 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 768493004495 ATP-grasp domain; Region: ATP-grasp_4; cl17255 768493004496 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 768493004497 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 768493004498 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 768493004499 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 768493004500 carboxyltransferase (CT) interaction site; other site 768493004501 biotinylation site [posttranslational modification]; other site 768493004502 Transcriptional regulators [Transcription]; Region: GntR; COG1802 768493004503 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768493004504 DNA-binding site [nucleotide binding]; DNA binding site 768493004505 FCD domain; Region: FCD; pfam07729 768493004506 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 768493004507 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 768493004508 putative ligand binding site [chemical binding]; other site 768493004509 HEAT repeats; Region: HEAT_2; pfam13646 768493004510 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 768493004511 TM-ABC transporter signature motif; other site 768493004512 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 768493004513 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 768493004514 TM-ABC transporter signature motif; other site 768493004515 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 768493004516 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 768493004517 Walker A/P-loop; other site 768493004518 ATP binding site [chemical binding]; other site 768493004519 Q-loop/lid; other site 768493004520 ABC transporter signature motif; other site 768493004521 Walker B; other site 768493004522 D-loop; other site 768493004523 H-loop/switch region; other site 768493004524 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 768493004525 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 768493004526 Walker A/P-loop; other site 768493004527 ATP binding site [chemical binding]; other site 768493004528 Q-loop/lid; other site 768493004529 ABC transporter signature motif; other site 768493004530 Walker B; other site 768493004531 D-loop; other site 768493004532 H-loop/switch region; other site 768493004533 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 768493004534 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 768493004535 Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933 768493004536 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 768493004537 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 768493004538 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768493004539 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768493004540 hypothetical protein; Provisional; Region: PRK06185 768493004541 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 768493004542 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 768493004543 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493004544 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768493004545 dimerization interface [polypeptide binding]; other site 768493004546 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 768493004547 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 768493004548 active site residue [active] 768493004549 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 768493004550 active site residue [active] 768493004551 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 768493004552 nudix motif; other site 768493004553 Uncharacterized conserved protein [Function unknown]; Region: COG1683 768493004554 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768493004555 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 768493004556 NAD(P) binding site [chemical binding]; other site 768493004557 active site 768493004558 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 768493004559 Helix-turn-helix domain; Region: HTH_18; pfam12833 768493004560 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768493004561 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768493004562 DNA-binding site [nucleotide binding]; DNA binding site 768493004563 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768493004564 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493004565 homodimer interface [polypeptide binding]; other site 768493004566 catalytic residue [active] 768493004567 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 768493004568 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 768493004569 putative C-terminal domain interface [polypeptide binding]; other site 768493004570 putative GSH binding site (G-site) [chemical binding]; other site 768493004571 putative dimer interface [polypeptide binding]; other site 768493004572 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 768493004573 putative N-terminal domain interface [polypeptide binding]; other site 768493004574 putative dimer interface [polypeptide binding]; other site 768493004575 putative substrate binding pocket (H-site) [chemical binding]; other site 768493004576 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768493004577 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768493004578 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 768493004579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 768493004580 Isochorismatase family; Region: Isochorismatase; pfam00857 768493004581 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 768493004582 catalytic triad [active] 768493004583 dimer interface [polypeptide binding]; other site 768493004584 conserved cis-peptide bond; other site 768493004585 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493004586 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493004587 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768493004588 dimerization interface [polypeptide binding]; other site 768493004589 Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764 768493004590 Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509 768493004591 Fatty acid desaturase; Region: FA_desaturase; pfam00487 768493004592 putative di-iron ligands [ion binding]; other site 768493004593 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 768493004594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493004595 dimer interface [polypeptide binding]; other site 768493004596 conserved gate region; other site 768493004597 ABC-ATPase subunit interface; other site 768493004598 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 768493004599 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 768493004600 Walker A/P-loop; other site 768493004601 ATP binding site [chemical binding]; other site 768493004602 Q-loop/lid; other site 768493004603 ABC transporter signature motif; other site 768493004604 Walker B; other site 768493004605 D-loop; other site 768493004606 H-loop/switch region; other site 768493004607 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 768493004608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493004609 putative PBP binding loops; other site 768493004610 dimer interface [polypeptide binding]; other site 768493004611 ABC-ATPase subunit interface; other site 768493004612 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 768493004613 short chain dehydrogenase; Provisional; Region: PRK07041 768493004614 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768493004615 NAD(P) binding site [chemical binding]; other site 768493004616 active site 768493004617 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493004618 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493004619 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768493004620 putative effector binding pocket; other site 768493004621 dimerization interface [polypeptide binding]; other site 768493004622 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 768493004623 EamA-like transporter family; Region: EamA; pfam00892 768493004624 EamA-like transporter family; Region: EamA; pfam00892 768493004625 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 768493004626 Predicted transcriptional regulator [Transcription]; Region: COG2345 768493004627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493004628 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768493004629 putative substrate translocation pore; other site 768493004630 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768493004631 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768493004632 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493004633 AzlC protein; Region: AzlC; cl00570 768493004634 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 768493004635 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768493004636 non-specific DNA binding site [nucleotide binding]; other site 768493004637 salt bridge; other site 768493004638 sequence-specific DNA binding site [nucleotide binding]; other site 768493004639 putative acetyltransferase; Provisional; Region: PRK03624 768493004640 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493004641 Coenzyme A binding pocket [chemical binding]; other site 768493004642 Predicted secreted acid phosphatase [General function prediction only]; Region: COG2503 768493004643 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493004644 Coenzyme A binding pocket [chemical binding]; other site 768493004645 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 768493004646 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 768493004647 trimer interface [polypeptide binding]; other site 768493004648 eyelet of channel; other site 768493004649 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 768493004650 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 768493004651 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 768493004652 DEAD_2; Region: DEAD_2; pfam06733 768493004653 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 768493004654 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768493004655 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768493004656 putative DNA binding site [nucleotide binding]; other site 768493004657 putative Zn2+ binding site [ion binding]; other site 768493004658 AsnC family; Region: AsnC_trans_reg; pfam01037 768493004659 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768493004660 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 768493004661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493004662 putative substrate translocation pore; other site 768493004663 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493004664 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493004665 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 768493004666 putative effector binding pocket; other site 768493004667 putative dimerization interface [polypeptide binding]; other site 768493004668 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 768493004669 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768493004670 salt bridge; other site 768493004671 non-specific DNA binding site [nucleotide binding]; other site 768493004672 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768493004673 sequence-specific DNA binding site [nucleotide binding]; other site 768493004674 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 768493004675 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 768493004676 glycosyl transferase family protein; Provisional; Region: PRK08136 768493004677 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 768493004678 Peptidase M3-like family, a zincin metallopeptidase, includes M3 and M32 families; Region: M3_like; cd06258 768493004679 active site 768493004680 Zn binding site [ion binding]; other site 768493004681 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 768493004682 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 768493004683 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 768493004684 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493004685 S-adenosylmethionine binding site [chemical binding]; other site 768493004686 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 768493004687 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 768493004688 Walker A/P-loop; other site 768493004689 ATP binding site [chemical binding]; other site 768493004690 Q-loop/lid; other site 768493004691 ABC transporter signature motif; other site 768493004692 Walker B; other site 768493004693 D-loop; other site 768493004694 H-loop/switch region; other site 768493004695 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768493004696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493004697 dimer interface [polypeptide binding]; other site 768493004698 conserved gate region; other site 768493004699 putative PBP binding loops; other site 768493004700 ABC-ATPase subunit interface; other site 768493004701 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 768493004702 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768493004703 substrate binding pocket [chemical binding]; other site 768493004704 membrane-bound complex binding site; other site 768493004705 hinge residues; other site 768493004706 hypothetical protein; Provisional; Region: PRK11019 768493004707 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 768493004708 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 768493004709 dimerization interface [polypeptide binding]; other site 768493004710 DPS ferroxidase diiron center [ion binding]; other site 768493004711 ion pore; other site 768493004712 AAA domain; Region: AAA_17; pfam13207 768493004713 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 768493004714 threonine and homoserine efflux system; Provisional; Region: PRK10532 768493004715 EamA-like transporter family; Region: EamA; pfam00892 768493004716 outer membrane protein X; Provisional; Region: ompX; PRK09408 768493004717 Predicted amidohydrolase [General function prediction only]; Region: COG0388 768493004718 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_7; cd07585 768493004719 putative active site [active] 768493004720 catalytic triad [active] 768493004721 putative dimer interface [polypeptide binding]; other site 768493004722 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493004723 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493004724 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 768493004725 dimerization interface [polypeptide binding]; other site 768493004726 substrate binding pocket [chemical binding]; other site 768493004727 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768493004728 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768493004729 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 768493004730 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 768493004731 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 768493004732 Moco binding site; other site 768493004733 metal coordination site [ion binding]; other site 768493004734 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 768493004735 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768493004736 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768493004737 dimerization interface [polypeptide binding]; other site 768493004738 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768493004739 dimer interface [polypeptide binding]; other site 768493004740 phosphorylation site [posttranslational modification] 768493004741 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493004742 ATP binding site [chemical binding]; other site 768493004743 Mg2+ binding site [ion binding]; other site 768493004744 G-X-G motif; other site 768493004745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768493004746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493004747 active site 768493004748 phosphorylation site [posttranslational modification] 768493004749 intermolecular recognition site; other site 768493004750 dimerization interface [polypeptide binding]; other site 768493004751 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768493004752 DNA binding site [nucleotide binding] 768493004753 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 768493004754 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 768493004755 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 768493004756 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 768493004757 Moco binding site; other site 768493004758 metal coordination site [ion binding]; other site 768493004759 choline transport protein BetT; Provisional; Region: PRK09928 768493004760 transcriptional regulator BetI; Validated; Region: PRK00767 768493004761 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768493004762 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 768493004763 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 768493004764 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 768493004765 tetrameric interface [polypeptide binding]; other site 768493004766 NAD binding site [chemical binding]; other site 768493004767 catalytic residues [active] 768493004768 choline dehydrogenase; Validated; Region: PRK02106 768493004769 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 768493004770 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 768493004771 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 768493004772 active site 768493004773 FMN binding site [chemical binding]; other site 768493004774 substrate binding site [chemical binding]; other site 768493004775 3Fe-4S cluster binding site [ion binding]; other site 768493004776 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 768493004777 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 768493004778 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768493004779 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 768493004780 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 768493004781 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 768493004782 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 768493004783 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 768493004784 PapC N-terminal domain; Region: PapC_N; pfam13954 768493004785 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 768493004786 PapC C-terminal domain; Region: PapC_C; pfam13953 768493004787 putative major fimbrial protein SthE; Provisional; Region: PRK15292 768493004788 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 768493004789 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 768493004790 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493004791 malate:quinone oxidoreductase; Validated; Region: PRK05257 768493004792 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 768493004793 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768493004794 NADH(P)-binding; Region: NAD_binding_10; pfam13460 768493004795 NAD(P) binding site [chemical binding]; other site 768493004796 active site 768493004797 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768493004798 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768493004799 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768493004800 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768493004801 alkaline phosphatase; Provisional; Region: PRK10518 768493004802 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 768493004803 dimer interface [polypeptide binding]; other site 768493004804 active site 768493004805 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 768493004806 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 768493004807 C-terminal domain interface [polypeptide binding]; other site 768493004808 GSH binding site (G-site) [chemical binding]; other site 768493004809 dimer interface [polypeptide binding]; other site 768493004810 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 768493004811 dimer interface [polypeptide binding]; other site 768493004812 N-terminal domain interface [polypeptide binding]; other site 768493004813 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768493004814 dimerization interface [polypeptide binding]; other site 768493004815 putative DNA binding site [nucleotide binding]; other site 768493004816 putative Zn2+ binding site [ion binding]; other site 768493004817 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 768493004818 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 768493004819 Isochorismatase family; Region: Isochorismatase; pfam00857 768493004820 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 768493004821 catalytic triad [active] 768493004822 conserved cis-peptide bond; other site 768493004823 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493004824 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493004825 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768493004826 putative effector binding pocket; other site 768493004827 dimerization interface [polypeptide binding]; other site 768493004828 AAA domain; Region: AAA_33; pfam13671 768493004829 AAA domain; Region: AAA_17; pfam13207 768493004830 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493004831 metabolite-proton symporter; Region: 2A0106; TIGR00883 768493004832 putative substrate translocation pore; other site 768493004833 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493004834 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493004835 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768493004836 putative effector binding pocket; other site 768493004837 dimerization interface [polypeptide binding]; other site 768493004838 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 768493004839 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768493004840 Walker A/P-loop; other site 768493004841 ATP binding site [chemical binding]; other site 768493004842 Q-loop/lid; other site 768493004843 ABC transporter signature motif; other site 768493004844 Walker B; other site 768493004845 D-loop; other site 768493004846 H-loop/switch region; other site 768493004847 ABC transporter; Region: ABC_tran_2; pfam12848 768493004848 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768493004849 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 768493004850 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 768493004851 ATP binding site [chemical binding]; other site 768493004852 substrate interface [chemical binding]; other site 768493004853 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 768493004854 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 768493004855 dimer interface [polypeptide binding]; other site 768493004856 putative functional site; other site 768493004857 putative MPT binding site; other site 768493004858 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 768493004859 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 768493004860 catalytic nucleophile [active] 768493004861 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 768493004862 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768493004863 Walker A/P-loop; other site 768493004864 ATP binding site [chemical binding]; other site 768493004865 Q-loop/lid; other site 768493004866 ABC transporter signature motif; other site 768493004867 Walker B; other site 768493004868 D-loop; other site 768493004869 H-loop/switch region; other site 768493004870 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768493004871 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768493004872 Walker A/P-loop; other site 768493004873 ATP binding site [chemical binding]; other site 768493004874 Q-loop/lid; other site 768493004875 ABC transporter signature motif; other site 768493004876 Walker B; other site 768493004877 D-loop; other site 768493004878 H-loop/switch region; other site 768493004879 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768493004880 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 768493004881 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 768493004882 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 768493004883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493004884 dimer interface [polypeptide binding]; other site 768493004885 conserved gate region; other site 768493004886 putative PBP binding loops; other site 768493004887 ABC-ATPase subunit interface; other site 768493004888 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 768493004889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493004890 dimer interface [polypeptide binding]; other site 768493004891 conserved gate region; other site 768493004892 putative PBP binding loops; other site 768493004893 ABC-ATPase subunit interface; other site 768493004894 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 768493004895 CcdB protein; Region: CcdB; pfam01845 768493004896 S-formylglutathione hydrolase; Region: PLN02442 768493004897 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 768493004898 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 768493004899 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 768493004900 substrate binding site [chemical binding]; other site 768493004901 catalytic Zn binding site [ion binding]; other site 768493004902 NAD binding site [chemical binding]; other site 768493004903 structural Zn binding site [ion binding]; other site 768493004904 dimer interface [polypeptide binding]; other site 768493004905 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493004906 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493004907 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 768493004908 putative dimerization interface [polypeptide binding]; other site 768493004909 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493004910 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768493004911 putative substrate translocation pore; other site 768493004912 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 768493004913 active site 768493004914 Predicted membrane protein [Function unknown]; Region: COG2311 768493004915 hypothetical protein; Provisional; Region: PRK10835 768493004916 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 768493004917 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768493004918 DNA binding site [nucleotide binding] 768493004919 domain linker motif; other site 768493004920 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 768493004921 dimerization interface (closed form) [polypeptide binding]; other site 768493004922 ligand binding site [chemical binding]; other site 768493004923 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 768493004924 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 768493004925 ligand binding site [chemical binding]; other site 768493004926 calcium binding site [ion binding]; other site 768493004927 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768493004928 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 768493004929 Walker A/P-loop; other site 768493004930 ATP binding site [chemical binding]; other site 768493004931 Q-loop/lid; other site 768493004932 ABC transporter signature motif; other site 768493004933 Walker B; other site 768493004934 D-loop; other site 768493004935 H-loop/switch region; other site 768493004936 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768493004937 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768493004938 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768493004939 TM-ABC transporter signature motif; other site 768493004940 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 768493004941 putative active site [active] 768493004942 malate dehydrogenase; Provisional; Region: PRK13529 768493004943 Malic enzyme, N-terminal domain; Region: malic; pfam00390 768493004944 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 768493004945 NAD(P) binding site [chemical binding]; other site 768493004946 cytidine deaminase; Provisional; Region: PRK09027 768493004947 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 768493004948 active site 768493004949 catalytic motif [active] 768493004950 Zn binding site [ion binding]; other site 768493004951 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 768493004952 active site 768493004953 catalytic motif [active] 768493004954 Zn binding site [ion binding]; other site 768493004955 hypothetical protein; Provisional; Region: PRK10711 768493004956 hypothetical protein; Provisional; Region: PRK01821 768493004957 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768493004958 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493004959 putative substrate translocation pore; other site 768493004960 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 768493004961 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 768493004962 putative ligand binding site [chemical binding]; other site 768493004963 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 768493004964 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 768493004965 active site 768493004966 HIGH motif; other site 768493004967 KMSKS motif; other site 768493004968 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 768493004969 tRNA binding surface [nucleotide binding]; other site 768493004970 anticodon binding site; other site 768493004971 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 768493004972 dimer interface [polypeptide binding]; other site 768493004973 putative tRNA-binding site [nucleotide binding]; other site 768493004974 antiporter inner membrane protein; Provisional; Region: PRK11670 768493004975 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 768493004976 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 768493004977 active site 768493004978 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 768493004979 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 768493004980 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 768493004981 ATP-binding site [chemical binding]; other site 768493004982 Sugar specificity; other site 768493004983 Pyrimidine base specificity; other site 768493004984 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 768493004985 trimer interface [polypeptide binding]; other site 768493004986 active site 768493004987 putative assembly protein; Provisional; Region: PRK10833 768493004988 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 768493004989 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 768493004990 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 768493004991 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 768493004992 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 768493004993 FOG: CBS domain [General function prediction only]; Region: COG0517 768493004994 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 768493004995 Transporter associated domain; Region: CorC_HlyC; smart01091 768493004996 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 768493004997 active site 768493004998 tetramer interface; other site 768493004999 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 768493005000 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 768493005001 active site 768493005002 tetramer interface; other site 768493005003 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 768493005004 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 768493005005 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 768493005006 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768493005007 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 768493005008 polysaccharide export protein Wza; Provisional; Region: PRK15078 768493005009 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 768493005010 SLBB domain; Region: SLBB; pfam10531 768493005011 SLBB domain; Region: SLBB; pfam10531 768493005012 Low molecular weight phosphatase family; Region: LMWPc; cd00115 768493005013 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 768493005014 active site 768493005015 tyrosine kinase; Provisional; Region: PRK11519 768493005016 Chain length determinant protein; Region: Wzz; pfam02706 768493005017 Chain length determinant protein; Region: Wzz; cl15801 768493005018 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 768493005019 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 768493005020 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 768493005021 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 768493005022 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768493005023 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 768493005024 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768493005025 putative ADP-binding pocket [chemical binding]; other site 768493005026 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 768493005027 Bacterial sugar transferase; Region: Bac_transf; pfam02397 768493005028 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 768493005029 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 768493005030 Walker A/P-loop; other site 768493005031 ATP binding site [chemical binding]; other site 768493005032 Q-loop/lid; other site 768493005033 ABC transporter signature motif; other site 768493005034 Walker B; other site 768493005035 D-loop; other site 768493005036 H-loop/switch region; other site 768493005037 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 768493005038 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768493005039 HlyD family secretion protein; Region: HlyD_3; pfam13437 768493005040 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 768493005041 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 768493005042 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 768493005043 Substrate binding site; other site 768493005044 Cupin domain; Region: Cupin_2; cl17218 768493005045 phosphomannomutase CpsG; Provisional; Region: PRK15414 768493005046 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 768493005047 active site 768493005048 substrate binding site [chemical binding]; other site 768493005049 metal binding site [ion binding]; metal-binding site 768493005050 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 768493005051 UDP-glucose 4-epimerase; Region: PLN02240 768493005052 NAD binding site [chemical binding]; other site 768493005053 homodimer interface [polypeptide binding]; other site 768493005054 active site 768493005055 substrate binding site [chemical binding]; other site 768493005056 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 768493005057 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 768493005058 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 768493005059 NADP binding site [chemical binding]; other site 768493005060 active site 768493005061 putative substrate binding site [chemical binding]; other site 768493005062 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 768493005063 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 768493005064 active site 768493005065 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 768493005066 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 768493005067 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 768493005068 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 768493005069 Walker A/P-loop; other site 768493005070 ATP binding site [chemical binding]; other site 768493005071 Q-loop/lid; other site 768493005072 ABC transporter signature motif; other site 768493005073 Walker B; other site 768493005074 D-loop; other site 768493005075 H-loop/switch region; other site 768493005076 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 768493005077 putative carbohydrate binding site [chemical binding]; other site 768493005078 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 768493005079 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 768493005080 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 768493005081 active site 768493005082 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768493005083 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 768493005084 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 768493005085 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 768493005086 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 768493005087 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 768493005088 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 768493005089 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 768493005090 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 768493005091 metal binding site [ion binding]; metal-binding site 768493005092 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 768493005093 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 768493005094 substrate binding site [chemical binding]; other site 768493005095 glutamase interaction surface [polypeptide binding]; other site 768493005096 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 768493005097 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 768493005098 catalytic residues [active] 768493005099 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 768493005100 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 768493005101 putative active site [active] 768493005102 oxyanion strand; other site 768493005103 catalytic triad [active] 768493005104 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 768493005105 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768493005106 active site 768493005107 motif I; other site 768493005108 motif II; other site 768493005109 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 768493005110 putative active site pocket [active] 768493005111 4-fold oligomerization interface [polypeptide binding]; other site 768493005112 metal binding residues [ion binding]; metal-binding site 768493005113 3-fold/trimer interface [polypeptide binding]; other site 768493005114 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 768493005115 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768493005116 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493005117 homodimer interface [polypeptide binding]; other site 768493005118 catalytic residue [active] 768493005119 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 768493005120 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 768493005121 NAD binding site [chemical binding]; other site 768493005122 dimerization interface [polypeptide binding]; other site 768493005123 product binding site; other site 768493005124 substrate binding site [chemical binding]; other site 768493005125 zinc binding site [ion binding]; other site 768493005126 catalytic residues [active] 768493005127 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 768493005128 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 768493005129 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 768493005130 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768493005131 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 768493005132 putative NAD(P) binding site [chemical binding]; other site 768493005133 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493005134 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493005135 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768493005136 dimerization interface [polypeptide binding]; other site 768493005137 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 768493005138 agmatinase; Region: agmatinase; TIGR01230 768493005139 oligomer interface [polypeptide binding]; other site 768493005140 putative active site [active] 768493005141 Mn binding site [ion binding]; other site 768493005142 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 768493005143 Na binding site [ion binding]; other site 768493005144 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 768493005145 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 768493005146 oligomer interface [polypeptide binding]; other site 768493005147 metal binding site [ion binding]; metal-binding site 768493005148 metal binding site [ion binding]; metal-binding site 768493005149 putative Cl binding site [ion binding]; other site 768493005150 basic sphincter; other site 768493005151 hydrophobic gate; other site 768493005152 periplasmic entrance; other site 768493005153 putative acetyltransferase; Provisional; Region: PRK03624 768493005154 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493005155 Coenzyme A binding pocket [chemical binding]; other site 768493005156 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 768493005157 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 768493005158 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 768493005159 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 768493005160 putative C-terminal domain interface [polypeptide binding]; other site 768493005161 putative GSH binding site (G-site) [chemical binding]; other site 768493005162 putative dimer interface [polypeptide binding]; other site 768493005163 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 768493005164 putative N-terminal domain interface [polypeptide binding]; other site 768493005165 putative dimer interface [polypeptide binding]; other site 768493005166 putative substrate binding pocket (H-site) [chemical binding]; other site 768493005167 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 768493005168 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 768493005169 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 768493005170 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 768493005171 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 768493005172 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 768493005173 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 768493005174 homodimer interface [polypeptide binding]; other site 768493005175 substrate-cofactor binding pocket; other site 768493005176 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493005177 catalytic residue [active] 768493005178 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 768493005179 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 768493005180 dimer interface [polypeptide binding]; other site 768493005181 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493005182 catalytic residue [active] 768493005183 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 768493005184 FOG: CBS domain [General function prediction only]; Region: COG0517 768493005185 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 768493005186 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 768493005187 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 768493005188 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 768493005189 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 768493005190 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 768493005191 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 768493005192 serine transporter; Region: stp; TIGR00814 768493005193 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 768493005194 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 768493005195 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 768493005196 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 768493005197 intersubunit interface [polypeptide binding]; other site 768493005198 active site 768493005199 catalytic residue [active] 768493005200 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 768493005201 active site 768493005202 catalytic residues [active] 768493005203 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 768493005204 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 768493005205 active site 768493005206 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 768493005207 active site 768493005208 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 768493005209 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 768493005210 secondary substrate binding site; other site 768493005211 primary substrate binding site; other site 768493005212 inhibition loop; other site 768493005213 dimerization interface [polypeptide binding]; other site 768493005214 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 768493005215 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 768493005216 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768493005217 catalytic residue [active] 768493005218 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 768493005219 Predicted transcriptional regulator [Transcription]; Region: COG3655 768493005220 sequence-specific DNA binding site [nucleotide binding]; other site 768493005221 salt bridge; other site 768493005222 Fucose-binding lectin II (PA-IIL); Region: PA-IIL; pfam07472 768493005223 putative transporter; Provisional; Region: PRK04972 768493005224 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 768493005225 TrkA-C domain; Region: TrkA_C; pfam02080 768493005226 TrkA-C domain; Region: TrkA_C; pfam02080 768493005227 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 768493005228 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 768493005229 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 768493005230 GSH binding site [chemical binding]; other site 768493005231 catalytic residues [active] 768493005232 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 768493005233 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 768493005234 RimK-like ATP-grasp domain; Region: RimK; pfam08443 768493005235 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 768493005236 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 768493005237 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 768493005238 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 768493005239 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 768493005240 Walker A/P-loop; other site 768493005241 ATP binding site [chemical binding]; other site 768493005242 Q-loop/lid; other site 768493005243 ABC transporter signature motif; other site 768493005244 Walker B; other site 768493005245 D-loop; other site 768493005246 H-loop/switch region; other site 768493005247 TOBE domain; Region: TOBE_2; pfam08402 768493005248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493005249 dimer interface [polypeptide binding]; other site 768493005250 conserved gate region; other site 768493005251 putative PBP binding loops; other site 768493005252 ABC-ATPase subunit interface; other site 768493005253 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 768493005254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493005255 dimer interface [polypeptide binding]; other site 768493005256 conserved gate region; other site 768493005257 putative PBP binding loops; other site 768493005258 ABC-ATPase subunit interface; other site 768493005259 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 768493005260 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 768493005261 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493005262 S-adenosylmethionine binding site [chemical binding]; other site 768493005263 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 768493005264 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768493005265 substrate binding pocket [chemical binding]; other site 768493005266 membrane-bound complex binding site; other site 768493005267 hinge residues; other site 768493005268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493005269 dimer interface [polypeptide binding]; other site 768493005270 conserved gate region; other site 768493005271 putative PBP binding loops; other site 768493005272 ABC-ATPase subunit interface; other site 768493005273 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768493005274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493005275 dimer interface [polypeptide binding]; other site 768493005276 conserved gate region; other site 768493005277 putative PBP binding loops; other site 768493005278 ABC-ATPase subunit interface; other site 768493005279 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 768493005280 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768493005281 substrate binding pocket [chemical binding]; other site 768493005282 membrane-bound complex binding site; other site 768493005283 hinge residues; other site 768493005284 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 768493005285 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768493005286 Walker A/P-loop; other site 768493005287 ATP binding site [chemical binding]; other site 768493005288 Q-loop/lid; other site 768493005289 ABC transporter signature motif; other site 768493005290 Walker B; other site 768493005291 D-loop; other site 768493005292 H-loop/switch region; other site 768493005293 putative lipoprotein; Provisional; Region: PRK10533 768493005294 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768493005295 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768493005296 dimerization interface [polypeptide binding]; other site 768493005297 putative DNA binding site [nucleotide binding]; other site 768493005298 putative Zn2+ binding site [ion binding]; other site 768493005299 AsnC family; Region: AsnC_trans_reg; pfam01037 768493005300 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 768493005301 hypothetical protein; Provisional; Region: PRK02877 768493005302 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 768493005303 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 768493005304 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 768493005305 amidase catalytic site [active] 768493005306 Zn binding residues [ion binding]; other site 768493005307 substrate binding site [chemical binding]; other site 768493005308 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768493005309 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768493005310 NAD(P) binding site [chemical binding]; other site 768493005311 active site 768493005312 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 768493005313 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 768493005314 putative NAD(P) binding site [chemical binding]; other site 768493005315 putative active site [active] 768493005316 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 768493005317 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 768493005318 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 768493005319 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 768493005320 tetramer interface [polypeptide binding]; other site 768493005321 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493005322 catalytic residue [active] 768493005323 pyruvate dehydrogenase; Provisional; Region: PRK09124 768493005324 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 768493005325 PYR/PP interface [polypeptide binding]; other site 768493005326 dimer interface [polypeptide binding]; other site 768493005327 tetramer interface [polypeptide binding]; other site 768493005328 TPP binding site [chemical binding]; other site 768493005329 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768493005330 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 768493005331 TPP-binding site [chemical binding]; other site 768493005332 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 768493005333 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 768493005334 FAD binding pocket [chemical binding]; other site 768493005335 FAD binding motif [chemical binding]; other site 768493005336 phosphate binding motif [ion binding]; other site 768493005337 beta-alpha-beta structure motif; other site 768493005338 NAD binding pocket [chemical binding]; other site 768493005339 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768493005340 catalytic loop [active] 768493005341 iron binding site [ion binding]; other site 768493005342 hybrid cluster protein; Provisional; Region: PRK05290 768493005343 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768493005344 ACS interaction site; other site 768493005345 CODH interaction site; other site 768493005346 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768493005347 ACS interaction site; other site 768493005348 CODH interaction site; other site 768493005349 metal cluster binding site [ion binding]; other site 768493005350 Predicted membrane protein [Function unknown]; Region: COG2431 768493005351 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 768493005352 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 768493005353 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 768493005354 putative active site [active] 768493005355 putative metal-binding site [ion binding]; other site 768493005356 Protein of unknown function (DUF535); Region: DUF535; pfam04393 768493005357 macrolide transporter subunit MacA; Provisional; Region: PRK11578 768493005358 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768493005359 HlyD family secretion protein; Region: HlyD_3; pfam13437 768493005360 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 768493005361 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768493005362 Walker A/P-loop; other site 768493005363 ATP binding site [chemical binding]; other site 768493005364 Q-loop/lid; other site 768493005365 ABC transporter signature motif; other site 768493005366 Walker B; other site 768493005367 D-loop; other site 768493005368 H-loop/switch region; other site 768493005369 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768493005370 FtsX-like permease family; Region: FtsX; pfam02687 768493005371 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768493005372 DNA-binding site [nucleotide binding]; DNA binding site 768493005373 RNA-binding motif; other site 768493005374 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 768493005375 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 768493005376 Clp amino terminal domain; Region: Clp_N; pfam02861 768493005377 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768493005378 Walker A motif; other site 768493005379 ATP binding site [chemical binding]; other site 768493005380 Walker B motif; other site 768493005381 arginine finger; other site 768493005382 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768493005383 Walker A motif; other site 768493005384 ATP binding site [chemical binding]; other site 768493005385 Walker B motif; other site 768493005386 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 768493005387 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 768493005388 rRNA binding site [nucleotide binding]; other site 768493005389 predicted 30S ribosome binding site; other site 768493005390 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 768493005391 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 768493005392 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768493005393 Walker A/P-loop; other site 768493005394 ATP binding site [chemical binding]; other site 768493005395 Q-loop/lid; other site 768493005396 ABC transporter signature motif; other site 768493005397 Walker B; other site 768493005398 D-loop; other site 768493005399 H-loop/switch region; other site 768493005400 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 768493005401 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768493005402 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768493005403 Walker A/P-loop; other site 768493005404 ATP binding site [chemical binding]; other site 768493005405 Q-loop/lid; other site 768493005406 ABC transporter signature motif; other site 768493005407 Walker B; other site 768493005408 D-loop; other site 768493005409 H-loop/switch region; other site 768493005410 glutathionine S-transferase; Provisional; Region: PRK10542 768493005411 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 768493005412 C-terminal domain interface [polypeptide binding]; other site 768493005413 GSH binding site (G-site) [chemical binding]; other site 768493005414 dimer interface [polypeptide binding]; other site 768493005415 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 768493005416 dimer interface [polypeptide binding]; other site 768493005417 N-terminal domain interface [polypeptide binding]; other site 768493005418 substrate binding pocket (H-site) [chemical binding]; other site 768493005419 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493005420 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493005421 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768493005422 dimerization interface [polypeptide binding]; other site 768493005423 thioredoxin reductase; Provisional; Region: PRK10262 768493005424 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768493005425 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768493005426 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 768493005427 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768493005428 putative DNA binding site [nucleotide binding]; other site 768493005429 putative Zn2+ binding site [ion binding]; other site 768493005430 AsnC family; Region: AsnC_trans_reg; pfam01037 768493005431 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 768493005432 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 768493005433 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 768493005434 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 768493005435 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 768493005436 recombination factor protein RarA; Reviewed; Region: PRK13342 768493005437 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768493005438 Walker A motif; other site 768493005439 ATP binding site [chemical binding]; other site 768493005440 Walker B motif; other site 768493005441 arginine finger; other site 768493005442 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 768493005443 seryl-tRNA synthetase; Provisional; Region: PRK05431 768493005444 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 768493005445 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 768493005446 dimer interface [polypeptide binding]; other site 768493005447 active site 768493005448 motif 1; other site 768493005449 motif 2; other site 768493005450 motif 3; other site 768493005451 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 768493005452 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768493005453 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768493005454 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493005455 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 768493005456 putative MFS family transporter protein; Provisional; Region: PRK03633 768493005457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493005458 putative substrate translocation pore; other site 768493005459 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 768493005460 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768493005461 FeS/SAM binding site; other site 768493005462 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 768493005463 Pyruvate formate lyase 1; Region: PFL1; cd01678 768493005464 coenzyme A binding site [chemical binding]; other site 768493005465 active site 768493005466 catalytic residues [active] 768493005467 glycine loop; other site 768493005468 formate transporter; Provisional; Region: PRK10805 768493005469 uncharacterized domain; Region: TIGR00702 768493005470 YcaO-like family; Region: YcaO; pfam02624 768493005471 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 768493005472 homodimer interface [polypeptide binding]; other site 768493005473 active site 768493005474 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 768493005475 homodimer interface [polypeptide binding]; other site 768493005476 substrate-cofactor binding pocket; other site 768493005477 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493005478 catalytic residue [active] 768493005479 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 768493005480 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 768493005481 hinge; other site 768493005482 active site 768493005483 cytidylate kinase; Provisional; Region: cmk; PRK00023 768493005484 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 768493005485 CMP-binding site; other site 768493005486 The sites determining sugar specificity; other site 768493005487 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 768493005488 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 768493005489 RNA binding site [nucleotide binding]; other site 768493005490 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 768493005491 RNA binding site [nucleotide binding]; other site 768493005492 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 768493005493 RNA binding site [nucleotide binding]; other site 768493005494 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 768493005495 RNA binding site [nucleotide binding]; other site 768493005496 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 768493005497 RNA binding site [nucleotide binding]; other site 768493005498 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 768493005499 IHF dimer interface [polypeptide binding]; other site 768493005500 IHF - DNA interface [nucleotide binding]; other site 768493005501 ComEC family competence protein; Provisional; Region: PRK11539 768493005502 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 768493005503 Competence protein; Region: Competence; pfam03772 768493005504 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 768493005505 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 768493005506 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768493005507 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 768493005508 Walker A/P-loop; other site 768493005509 ATP binding site [chemical binding]; other site 768493005510 Q-loop/lid; other site 768493005511 ABC transporter signature motif; other site 768493005512 Walker B; other site 768493005513 D-loop; other site 768493005514 H-loop/switch region; other site 768493005515 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 768493005516 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 768493005517 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 768493005518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 768493005519 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768493005520 DNA-binding site [nucleotide binding]; DNA binding site 768493005521 RNA-binding motif; other site 768493005522 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768493005523 DNA-binding site [nucleotide binding]; DNA binding site 768493005524 RNA-binding motif; other site 768493005525 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 768493005526 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 768493005527 Trm112p-like protein; Region: Trm112p; cl01066 768493005528 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 768493005529 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 768493005530 Ligand binding site; other site 768493005531 oligomer interface; other site 768493005532 hypothetical protein; Provisional; Region: PRK10593 768493005533 Uncharacterized conserved protein [Function unknown]; Region: COG1434 768493005534 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 768493005535 putative active site [active] 768493005536 Methyltransferase domain; Region: Methyltransf_31; pfam13847 768493005537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493005538 S-adenosylmethionine binding site [chemical binding]; other site 768493005539 condesin subunit F; Provisional; Region: PRK05260 768493005540 condesin subunit E; Provisional; Region: PRK05256 768493005541 cell division protein MukB; Provisional; Region: mukB; PRK04863 768493005542 P-loop containing region of AAA domain; Region: AAA_29; cl17516 768493005543 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 768493005544 murein L,D-transpeptidase; Provisional; Region: PRK10594 768493005545 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 768493005546 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 768493005547 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 768493005548 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 768493005549 Peptidase M15; Region: Peptidase_M15_3; cl01194 768493005550 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 768493005551 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 768493005552 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768493005553 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493005554 homodimer interface [polypeptide binding]; other site 768493005555 catalytic residue [active] 768493005556 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 768493005557 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 768493005558 trimer interface [polypeptide binding]; other site 768493005559 eyelet of channel; other site 768493005560 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 768493005561 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 768493005562 putative dimer interface [polypeptide binding]; other site 768493005563 putative anticodon binding site; other site 768493005564 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 768493005565 homodimer interface [polypeptide binding]; other site 768493005566 motif 1; other site 768493005567 motif 2; other site 768493005568 active site 768493005569 motif 3; other site 768493005570 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 768493005571 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 768493005572 active site 768493005573 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768493005574 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768493005575 metal binding site [ion binding]; metal-binding site 768493005576 active site 768493005577 I-site; other site 768493005578 aminopeptidase N; Provisional; Region: pepN; PRK14015 768493005579 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 768493005580 active site 768493005581 Zn binding site [ion binding]; other site 768493005582 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 768493005583 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 768493005584 Walker A/P-loop; other site 768493005585 ATP binding site [chemical binding]; other site 768493005586 Q-loop/lid; other site 768493005587 ABC transporter signature motif; other site 768493005588 Walker B; other site 768493005589 D-loop; other site 768493005590 H-loop/switch region; other site 768493005591 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 768493005592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493005593 dimer interface [polypeptide binding]; other site 768493005594 conserved gate region; other site 768493005595 putative PBP binding loops; other site 768493005596 ABC-ATPase subunit interface; other site 768493005597 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 768493005598 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 768493005599 active site 768493005600 dimer interface [polypeptide binding]; other site 768493005601 non-prolyl cis peptide bond; other site 768493005602 insertion regions; other site 768493005603 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 768493005604 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768493005605 substrate binding pocket [chemical binding]; other site 768493005606 membrane-bound complex binding site; other site 768493005607 hinge residues; other site 768493005608 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 768493005609 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768493005610 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 768493005611 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 768493005612 quinone interaction residues [chemical binding]; other site 768493005613 active site 768493005614 catalytic residues [active] 768493005615 FMN binding site [chemical binding]; other site 768493005616 substrate binding site [chemical binding]; other site 768493005617 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 768493005618 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 768493005619 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 768493005620 MOSC domain; Region: MOSC; pfam03473 768493005621 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768493005622 catalytic loop [active] 768493005623 iron binding site [ion binding]; other site 768493005624 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 768493005625 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 768493005626 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493005627 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493005628 S-adenosylmethionine binding site [chemical binding]; other site 768493005629 ABC transporter ATPase component; Reviewed; Region: PRK11147 768493005630 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768493005631 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768493005632 Walker A/P-loop; other site 768493005633 Walker A/P-loop; other site 768493005634 ATP binding site [chemical binding]; other site 768493005635 ATP binding site [chemical binding]; other site 768493005636 Q-loop/lid; other site 768493005637 Q-loop/lid; other site 768493005638 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768493005639 ABC transporter signature motif; other site 768493005640 Walker B; other site 768493005641 D-loop; other site 768493005642 ABC transporter; Region: ABC_tran_2; pfam12848 768493005643 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768493005644 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 768493005645 Paraquat-inducible protein A; Region: PqiA; pfam04403 768493005646 Paraquat-inducible protein A; Region: PqiA; pfam04403 768493005647 paraquat-inducible protein B; Provisional; Region: PRK10807 768493005648 mce related protein; Region: MCE; pfam02470 768493005649 mce related protein; Region: MCE; pfam02470 768493005650 mce related protein; Region: MCE; pfam02470 768493005651 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 768493005652 Protein of unknown function (DUF330); Region: DUF330; pfam03886 768493005653 Ribosome modulation factor; Region: RMF; pfam04957 768493005654 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 768493005655 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 768493005656 dimer interface [polypeptide binding]; other site 768493005657 active site 768493005658 Predicted transcriptional regulators [Transcription]; Region: COG1733 768493005659 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 768493005660 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 768493005661 active site 2 [active] 768493005662 dimer interface [polypeptide binding]; other site 768493005663 active site 1 [active] 768493005664 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 768493005665 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 768493005666 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 768493005667 outer membrane protein A; Reviewed; Region: PRK10808 768493005668 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 768493005669 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 768493005670 ligand binding site [chemical binding]; other site 768493005671 SOS cell division inhibitor; Provisional; Region: PRK10595 768493005672 TfoX N-terminal domain; Region: TfoX_N; pfam04993 768493005673 TfoX C-terminal domain; Region: TfoX_C; pfam04994 768493005674 TIGR01666 family membrane protein; Region: YCCS 768493005675 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 768493005676 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 768493005677 Predicted membrane protein [Function unknown]; Region: COG3304 768493005678 Domain of unknown function (DUF307); Region: DUF307; pfam03733 768493005679 Domain of unknown function (DUF307); Region: DUF307; pfam03733 768493005680 DNA helicase IV; Provisional; Region: helD; PRK11054 768493005681 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 768493005682 Part of AAA domain; Region: AAA_19; pfam13245 768493005683 Family description; Region: UvrD_C_2; pfam13538 768493005684 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 768493005685 active site 768493005686 dimer interfaces [polypeptide binding]; other site 768493005687 catalytic residues [active] 768493005688 hypothetical protein; Provisional; Region: PRK03641 768493005689 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 768493005690 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 768493005691 heat shock protein HspQ; Provisional; Region: PRK14129 768493005692 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 768493005693 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 768493005694 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 768493005695 putative RNA binding site [nucleotide binding]; other site 768493005696 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493005697 S-adenosylmethionine binding site [chemical binding]; other site 768493005698 acylphosphatase; Provisional; Region: PRK14426 768493005699 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 768493005700 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 768493005701 YccA-like proteins; Region: YccA_like; cd10433 768493005702 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 768493005703 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 768493005704 hypothetical protein; Provisional; Region: PRK14851 768493005705 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 768493005706 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 768493005707 REDY-like protein HapK; Region: HapK; pfam11639 768493005708 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 768493005709 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 768493005710 active site 768493005711 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 768493005712 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 768493005713 acyl-activating enzyme (AAE) consensus motif; other site 768493005714 AMP binding site [chemical binding]; other site 768493005715 Phosphopantetheine attachment site; Region: PP-binding; cl09936 768493005716 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 768493005717 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768493005718 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768493005719 catalytic residue [active] 768493005720 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 768493005721 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493005722 S-adenosylmethionine binding site [chemical binding]; other site 768493005723 Predicted dehydrogenase [General function prediction only]; Region: COG5322 768493005724 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 768493005725 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768493005726 inhibitor-cofactor binding pocket; inhibition site 768493005727 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493005728 catalytic residue [active] 768493005729 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 768493005730 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 768493005731 TPP-binding site [chemical binding]; other site 768493005732 phosphoenolpyruvate synthase; Validated; Region: PRK06241 768493005733 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 768493005734 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 768493005735 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 768493005736 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 768493005737 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 768493005738 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 768493005739 active site 768493005740 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 768493005741 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 768493005742 active site 768493005743 substrate binding site [chemical binding]; other site 768493005744 Mg2+ binding site [ion binding]; other site 768493005745 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 768493005746 LysE type translocator; Region: LysE; cl00565 768493005747 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 768493005748 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493005749 The C-terminal substrate binding domain of LysR-type transcriptional regulator TrpI, which is involved in control of tryptophan synthesis, contains type 2 periplasmic binding fold; Region: PBP2_TrpI; cd08482 768493005750 putative dimerization interface [polypeptide binding]; other site 768493005751 putative substrate binding pocket [chemical binding]; other site 768493005752 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768493005753 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768493005754 non-specific DNA binding site [nucleotide binding]; other site 768493005755 salt bridge; other site 768493005756 sequence-specific DNA binding site [nucleotide binding]; other site 768493005757 Cupin domain; Region: Cupin_2; cl17218 768493005758 EamA-like transporter family; Region: EamA; pfam00892 768493005759 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 768493005760 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 768493005761 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 768493005762 pyrimidine utilization protein D; Region: RutD; TIGR03611 768493005763 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 768493005764 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 768493005765 homotrimer interaction site [polypeptide binding]; other site 768493005766 putative active site [active] 768493005767 Isochorismatase family; Region: Isochorismatase; pfam00857 768493005768 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 768493005769 catalytic triad [active] 768493005770 conserved cis-peptide bond; other site 768493005771 pyrimidine utilization protein A; Region: RutA; TIGR03612 768493005772 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 768493005773 active site 768493005774 dimer interface [polypeptide binding]; other site 768493005775 non-prolyl cis peptide bond; other site 768493005776 insertion regions; other site 768493005777 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 768493005778 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768493005779 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 768493005780 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 768493005781 TolA C-terminal; Region: TolA; pfam06519 768493005782 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 768493005783 Uncharacterized conserved protein [Function unknown]; Region: COG1359 768493005784 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768493005785 enoyl-CoA hydratase; Provisional; Region: PRK05870 768493005786 substrate binding site [chemical binding]; other site 768493005787 oxyanion hole (OAH) forming residues; other site 768493005788 trimer interface [polypeptide binding]; other site 768493005789 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493005790 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768493005791 putative substrate translocation pore; other site 768493005792 5-aminolevulinate synthase; Validated; Region: PRK09064 768493005793 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 768493005794 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768493005795 catalytic residue [active] 768493005796 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 768493005797 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 768493005798 dimer interface [polypeptide binding]; other site 768493005799 active site 768493005800 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 768493005801 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 768493005802 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768493005803 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768493005804 transcriptional regulator TraR; Provisional; Region: PRK13870 768493005805 Autoinducer binding domain; Region: Autoind_bind; pfam03472 768493005806 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768493005807 DNA binding residues [nucleotide binding] 768493005808 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 768493005809 Ligand Binding Site [chemical binding]; other site 768493005810 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 768493005811 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 768493005812 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 768493005813 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 768493005814 dimer interface [polypeptide binding]; other site 768493005815 NADP binding site [chemical binding]; other site 768493005816 catalytic residues [active] 768493005817 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 768493005818 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 768493005819 inhibitor site; inhibition site 768493005820 active site 768493005821 dimer interface [polypeptide binding]; other site 768493005822 catalytic residue [active] 768493005823 PAS fold; Region: PAS_4; pfam08448 768493005824 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768493005825 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493005826 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 768493005827 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 768493005828 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 768493005829 hydroxyglutarate oxidase; Provisional; Region: PRK11728 768493005830 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 768493005831 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 768493005832 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 768493005833 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 768493005834 GlpM protein; Region: GlpM; pfam06942 768493005835 hypothetical protein; Provisional; Region: PRK10613 768493005836 response regulator; Provisional; Region: PRK09483 768493005837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493005838 active site 768493005839 phosphorylation site [posttranslational modification] 768493005840 intermolecular recognition site; other site 768493005841 dimerization interface [polypeptide binding]; other site 768493005842 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768493005843 DNA binding residues [nucleotide binding] 768493005844 dimerization interface [polypeptide binding]; other site 768493005845 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 768493005846 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 768493005847 GIY-YIG motif/motif A; other site 768493005848 active site 768493005849 catalytic site [active] 768493005850 putative DNA binding site [nucleotide binding]; other site 768493005851 metal binding site [ion binding]; metal-binding site 768493005852 UvrB/uvrC motif; Region: UVR; pfam02151 768493005853 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 768493005854 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 768493005855 phosphoethanolamine transferase; Provisional; Region: PRK11560 768493005856 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 768493005857 Sulfatase; Region: Sulfatase; pfam00884 768493005858 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 768493005859 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 768493005860 proline/glycine betaine transporter; Provisional; Region: PRK10642 768493005861 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493005862 putative substrate translocation pore; other site 768493005863 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 768493005864 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 768493005865 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 768493005866 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768493005867 Walker A/P-loop; other site 768493005868 ATP binding site [chemical binding]; other site 768493005869 Q-loop/lid; other site 768493005870 ABC transporter signature motif; other site 768493005871 Walker B; other site 768493005872 D-loop; other site 768493005873 H-loop/switch region; other site 768493005874 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768493005875 FtsX-like permease family; Region: FtsX; pfam02687 768493005876 macrolide transporter subunit MacA; Provisional; Region: PRK11578 768493005877 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768493005878 HlyD family secretion protein; Region: HlyD_3; pfam13437 768493005879 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 768493005880 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 768493005881 GIY-YIG motif/motif A; other site 768493005882 active site 768493005883 catalytic site [active] 768493005884 putative DNA binding site [nucleotide binding]; other site 768493005885 metal binding site [ion binding]; metal-binding site 768493005886 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 768493005887 potassium/proton antiporter; Reviewed; Region: PRK05326 768493005888 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 768493005889 TrkA-C domain; Region: TrkA_C; pfam02080 768493005890 Transporter associated domain; Region: CorC_HlyC; smart01091 768493005891 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 768493005892 Acyltransferase family; Region: Acyl_transf_3; pfam01757 768493005893 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 768493005894 Acyltransferase family; Region: Acyl_transf_3; pfam01757 768493005895 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 768493005896 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 768493005897 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 768493005898 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 768493005899 Ligand binding site; other site 768493005900 DXD motif; other site 768493005901 lipoprotein; Provisional; Region: PRK10175 768493005902 MsyB protein; Region: MsyB; cl08181 768493005903 2-isopropylmalate synthase; Validated; Region: PRK03739 768493005904 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 768493005905 active site 768493005906 catalytic residues [active] 768493005907 metal binding site [ion binding]; metal-binding site 768493005908 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 768493005909 Cupin domain; Region: Cupin_2; cl17218 768493005910 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768493005911 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493005912 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768493005913 dimerization interface [polypeptide binding]; other site 768493005914 putative DNA binding site [nucleotide binding]; other site 768493005915 putative Zn2+ binding site [ion binding]; other site 768493005916 Predicted transporter component [General function prediction only]; Region: COG2391 768493005917 Sulphur transport; Region: Sulf_transp; pfam04143 768493005918 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768493005919 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 768493005920 active site 768493005921 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 768493005922 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493005923 putative substrate translocation pore; other site 768493005924 POT family; Region: PTR2; cl17359 768493005925 drug efflux system protein MdtG; Provisional; Region: PRK09874 768493005926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493005927 putative substrate translocation pore; other site 768493005928 YCII-related domain; Region: YCII; cl00999 768493005929 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 768493005930 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 768493005931 putative acyl-acceptor binding pocket; other site 768493005932 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 768493005933 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 768493005934 active site 768493005935 FMN binding site [chemical binding]; other site 768493005936 substrate binding site [chemical binding]; other site 768493005937 homotetramer interface [polypeptide binding]; other site 768493005938 catalytic residue [active] 768493005939 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 768493005940 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 768493005941 active site residue [active] 768493005942 YceI-like domain; Region: YceI; cl01001 768493005943 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 768493005944 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 768493005945 Domain of unknown function DUF20; Region: UPF0118; pfam01594 768493005946 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 768493005947 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768493005948 DNA binding residues [nucleotide binding] 768493005949 dimerization interface [polypeptide binding]; other site 768493005950 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 768493005951 hydroxyglutarate oxidase; Provisional; Region: PRK11728 768493005952 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 768493005953 DNA damage-inducible protein I; Provisional; Region: PRK10597 768493005954 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 768493005955 active site 768493005956 substrate binding pocket [chemical binding]; other site 768493005957 dimer interface [polypeptide binding]; other site 768493005958 Uncharacterized conserved protein [Function unknown]; Region: COG1359 768493005959 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 768493005960 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 768493005961 homodimer interface [polypeptide binding]; other site 768493005962 oligonucleotide binding site [chemical binding]; other site 768493005963 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 768493005964 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 768493005965 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768493005966 RNA binding surface [nucleotide binding]; other site 768493005967 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 768493005968 active site 768493005969 Maf-like protein; Region: Maf; pfam02545 768493005970 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 768493005971 active site 768493005972 dimer interface [polypeptide binding]; other site 768493005973 hypothetical protein; Provisional; Region: PRK11193 768493005974 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 768493005975 putative phosphate acyltransferase; Provisional; Region: PRK05331 768493005976 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 768493005977 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 768493005978 dimer interface [polypeptide binding]; other site 768493005979 active site 768493005980 CoA binding pocket [chemical binding]; other site 768493005981 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 768493005982 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 768493005983 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 768493005984 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 768493005985 NAD(P) binding site [chemical binding]; other site 768493005986 homotetramer interface [polypeptide binding]; other site 768493005987 homodimer interface [polypeptide binding]; other site 768493005988 active site 768493005989 acyl carrier protein; Provisional; Region: acpP; PRK00982 768493005990 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 768493005991 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 768493005992 dimer interface [polypeptide binding]; other site 768493005993 active site 768493005994 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 768493005995 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 768493005996 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493005997 catalytic residue [active] 768493005998 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 768493005999 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 768493006000 dimerization interface [polypeptide binding]; other site 768493006001 thymidylate kinase; Validated; Region: tmk; PRK00698 768493006002 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 768493006003 TMP-binding site; other site 768493006004 ATP-binding site [chemical binding]; other site 768493006005 DNA polymerase III subunit delta'; Validated; Region: PRK07993 768493006006 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 768493006007 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 768493006008 active site 768493006009 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 768493006010 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768493006011 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768493006012 active site turn [active] 768493006013 phosphorylation site [posttranslational modification] 768493006014 manganese transport regulator MntR; Provisional; Region: PRK11050 768493006015 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768493006016 putative DNA binding site [nucleotide binding]; other site 768493006017 putative Zn2+ binding site [ion binding]; other site 768493006018 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 768493006019 manganese transport protein MntH; Reviewed; Region: PRK00701 768493006020 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 768493006021 Bacterial SH3 domain homologues; Region: SH3b; smart00287 768493006022 short chain dehydrogenase; Provisional; Region: PRK06500 768493006023 classical (c) SDRs; Region: SDR_c; cd05233 768493006024 NAD(P) binding site [chemical binding]; other site 768493006025 active site 768493006026 Predicted transcriptional regulators [Transcription]; Region: COG1733 768493006027 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 768493006028 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768493006029 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768493006030 substrate binding pocket [chemical binding]; other site 768493006031 membrane-bound complex binding site; other site 768493006032 hinge residues; other site 768493006033 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 768493006034 nucleotide binding site/active site [active] 768493006035 HIT family signature motif; other site 768493006036 catalytic residue [active] 768493006037 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 768493006038 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 768493006039 putative dimer interface [polypeptide binding]; other site 768493006040 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 768493006041 thiamine kinase; Region: ycfN_thiK; TIGR02721 768493006042 active site 768493006043 substrate binding site [chemical binding]; other site 768493006044 ATP binding site [chemical binding]; other site 768493006045 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 768493006046 beta-hexosaminidase; Provisional; Region: PRK05337 768493006047 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 768493006048 hypothetical protein; Provisional; Region: PRK04940 768493006049 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 768493006050 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768493006051 hypothetical protein; Provisional; Region: PRK11280 768493006052 Predicted transcriptional regulator [Transcription]; Region: COG1959 768493006053 Transcriptional regulator; Region: Rrf2; pfam02082 768493006054 Transcriptional regulator; Region: Rrf2; cl17282 768493006055 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 768493006056 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 768493006057 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768493006058 HlyD family secretion protein; Region: HlyD_3; pfam13437 768493006059 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 768493006060 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493006061 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493006062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493006063 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 768493006064 POT family; Region: PTR2; cl17359 768493006065 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 768493006066 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 768493006067 putative ligand binding site [chemical binding]; other site 768493006068 NAD binding site [chemical binding]; other site 768493006069 dimerization interface [polypeptide binding]; other site 768493006070 catalytic site [active] 768493006071 putative hydrolase; Validated; Region: PRK09248 768493006072 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 768493006073 active site 768493006074 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 768493006075 Protein of unknown function (DUF533); Region: DUF533; pfam04391 768493006076 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 768493006077 putative metal binding site [ion binding]; other site 768493006078 protease 2; Provisional; Region: PRK10115 768493006079 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 768493006080 exodeoxyribonuclease X; Provisional; Region: PRK07983 768493006081 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 768493006082 active site 768493006083 catalytic site [active] 768493006084 substrate binding site [chemical binding]; other site 768493006085 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 768493006086 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 768493006087 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 768493006088 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 768493006089 Ferritin-like domain; Region: Ferritin; pfam00210 768493006090 ferroxidase diiron center [ion binding]; other site 768493006091 CopC domain; Region: CopC; cl01012 768493006092 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 768493006093 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 768493006094 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768493006095 Isochorismatase family; Region: Isochorismatase; pfam00857 768493006096 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 768493006097 catalytic triad [active] 768493006098 conserved cis-peptide bond; other site 768493006099 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 768493006100 Homeodomain-like domain; Region: HTH_23; cl17451 768493006101 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 768493006102 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 768493006103 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 768493006104 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 768493006105 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 768493006106 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768493006107 salt bridge; other site 768493006108 non-specific DNA binding site [nucleotide binding]; other site 768493006109 sequence-specific DNA binding site [nucleotide binding]; other site 768493006110 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493006111 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493006112 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768493006113 dimerization interface [polypeptide binding]; other site 768493006114 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 768493006115 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 768493006116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493006117 active site 768493006118 phosphorylation site [posttranslational modification] 768493006119 intermolecular recognition site; other site 768493006120 dimerization interface [polypeptide binding]; other site 768493006121 sensory histidine kinase DcuS; Provisional; Region: PRK11086 768493006122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493006123 ATP binding site [chemical binding]; other site 768493006124 Mg2+ binding site [ion binding]; other site 768493006125 G-X-G motif; other site 768493006126 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 768493006127 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 768493006128 putative active site; other site 768493006129 catalytic residue [active] 768493006130 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 768493006131 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 768493006132 putative ligand binding site [chemical binding]; other site 768493006133 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 768493006134 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768493006135 Walker A/P-loop; other site 768493006136 ATP binding site [chemical binding]; other site 768493006137 Q-loop/lid; other site 768493006138 ABC transporter signature motif; other site 768493006139 Walker B; other site 768493006140 D-loop; other site 768493006141 H-loop/switch region; other site 768493006142 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768493006143 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768493006144 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768493006145 TM-ABC transporter signature motif; other site 768493006146 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 768493006147 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 768493006148 putative ligand binding site [chemical binding]; other site 768493006149 Right handed beta helix region; Region: Beta_helix; pfam13229 768493006150 Right handed beta helix region; Region: Beta_helix; pfam13229 768493006151 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 768493006152 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 768493006153 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 768493006154 Ligand Binding Site [chemical binding]; other site 768493006155 putative kinase; Provisional; Region: PRK09954 768493006156 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768493006157 putative DNA binding site [nucleotide binding]; other site 768493006158 putative Zn2+ binding site [ion binding]; other site 768493006159 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 768493006160 substrate binding site [chemical binding]; other site 768493006161 ATP binding site [chemical binding]; other site 768493006162 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 768493006163 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 768493006164 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 768493006165 Nucleoside recognition; Region: Gate; pfam07670 768493006166 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 768493006167 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 768493006168 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768493006169 dimerization interface [polypeptide binding]; other site 768493006170 putative DNA binding site [nucleotide binding]; other site 768493006171 putative Zn2+ binding site [ion binding]; other site 768493006172 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 768493006173 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 768493006174 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 768493006175 oligomer interface [polypeptide binding]; other site 768493006176 active site residues [active] 768493006177 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768493006178 PAS domain; Region: PAS_9; pfam13426 768493006179 putative active site [active] 768493006180 heme pocket [chemical binding]; other site 768493006181 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768493006182 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768493006183 metal binding site [ion binding]; metal-binding site 768493006184 active site 768493006185 I-site; other site 768493006186 GTP-binding protein YchF; Reviewed; Region: PRK09601 768493006187 YchF GTPase; Region: YchF; cd01900 768493006188 G1 box; other site 768493006189 GTP/Mg2+ binding site [chemical binding]; other site 768493006190 Switch I region; other site 768493006191 G2 box; other site 768493006192 Switch II region; other site 768493006193 G3 box; other site 768493006194 G4 box; other site 768493006195 G5 box; other site 768493006196 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 768493006197 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 768493006198 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 768493006199 Sulfate transporter family; Region: Sulfate_transp; pfam00916 768493006200 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 768493006201 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 768493006202 putative active site [active] 768493006203 catalytic residue [active] 768493006204 hypothetical protein; Provisional; Region: PRK10692 768493006205 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 768493006206 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 768493006207 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768493006208 active site 768493006209 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 768493006210 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 768493006211 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 768493006212 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 768493006213 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 768493006214 Chitin binding domain; Region: Chitin_bind_3; cl03871 768493006215 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 768493006216 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 768493006217 tRNA; other site 768493006218 putative tRNA binding site [nucleotide binding]; other site 768493006219 putative NADP binding site [chemical binding]; other site 768493006220 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 768493006221 peptide chain release factor 1; Validated; Region: prfA; PRK00591 768493006222 This domain is found in peptide chain release factors; Region: PCRF; smart00937 768493006223 RF-1 domain; Region: RF-1; pfam00472 768493006224 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 768493006225 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493006226 Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247 768493006227 hypothetical protein; Provisional; Region: PRK10941 768493006228 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 768493006229 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 768493006230 TPR motif; other site 768493006231 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 768493006232 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 768493006233 putative transporter; Provisional; Region: PRK11660 768493006234 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 768493006235 Sulfate transporter family; Region: Sulfate_transp; pfam00916 768493006236 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 768493006237 hypothetical protein; Provisional; Region: PRK02487 768493006238 transcription-repair coupling factor; Provisional; Region: PRK10689 768493006239 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 768493006240 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768493006241 ATP binding site [chemical binding]; other site 768493006242 putative Mg++ binding site [ion binding]; other site 768493006243 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768493006244 nucleotide binding region [chemical binding]; other site 768493006245 ATP-binding site [chemical binding]; other site 768493006246 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 768493006247 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 768493006248 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 768493006249 tetramer interface [polypeptide binding]; other site 768493006250 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493006251 catalytic residue [active] 768493006252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 768493006253 YheO-like PAS domain; Region: PAS_6; pfam08348 768493006254 HTH domain; Region: HTH_22; pfam13309 768493006255 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 768493006256 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768493006257 FtsX-like permease family; Region: FtsX; pfam02687 768493006258 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 768493006259 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768493006260 Walker A/P-loop; other site 768493006261 ATP binding site [chemical binding]; other site 768493006262 Q-loop/lid; other site 768493006263 ABC transporter signature motif; other site 768493006264 Walker B; other site 768493006265 D-loop; other site 768493006266 H-loop/switch region; other site 768493006267 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 768493006268 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768493006269 FtsX-like permease family; Region: FtsX; pfam02687 768493006270 fructokinase; Reviewed; Region: PRK09557 768493006271 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768493006272 nucleotide binding site [chemical binding]; other site 768493006273 NAD-dependent deacetylase; Provisional; Region: PRK00481 768493006274 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 768493006275 NAD+ binding site [chemical binding]; other site 768493006276 substrate binding site [chemical binding]; other site 768493006277 Zn binding site [ion binding]; other site 768493006278 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 768493006279 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768493006280 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768493006281 putative active site [active] 768493006282 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 768493006283 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 768493006284 NAD(P) binding site [chemical binding]; other site 768493006285 LDH/MDH dimer interface [polypeptide binding]; other site 768493006286 substrate binding site [chemical binding]; other site 768493006287 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768493006288 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 768493006289 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768493006290 active site turn [active] 768493006291 phosphorylation site [posttranslational modification] 768493006292 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 768493006293 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 768493006294 metal binding site [ion binding]; metal-binding site 768493006295 dimer interface [polypeptide binding]; other site 768493006296 putative dehydrogenase; Provisional; Region: PRK10098 768493006297 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 768493006298 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768493006299 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493006300 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768493006301 dimerization interface [polypeptide binding]; other site 768493006302 Uncharacterized conserved protein [Function unknown]; Region: COG2850 768493006303 Cupin domain; Region: Cupin_2; cl17218 768493006304 sensor protein PhoQ; Provisional; Region: PRK10815 768493006305 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 768493006306 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 768493006307 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493006308 ATP binding site [chemical binding]; other site 768493006309 Mg2+ binding site [ion binding]; other site 768493006310 G-X-G motif; other site 768493006311 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 768493006312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493006313 active site 768493006314 phosphorylation site [posttranslational modification] 768493006315 intermolecular recognition site; other site 768493006316 dimerization interface [polypeptide binding]; other site 768493006317 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768493006318 DNA binding site [nucleotide binding] 768493006319 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768493006320 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768493006321 DNA-binding site [nucleotide binding]; DNA binding site 768493006322 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768493006323 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493006324 homodimer interface [polypeptide binding]; other site 768493006325 catalytic residue [active] 768493006326 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768493006327 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493006328 Coenzyme A binding pocket [chemical binding]; other site 768493006329 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 768493006330 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768493006331 adenylosuccinate lyase; Provisional; Region: PRK09285 768493006332 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 768493006333 tetramer interface [polypeptide binding]; other site 768493006334 active site 768493006335 putative lysogenization regulator; Reviewed; Region: PRK00218 768493006336 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 768493006337 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 768493006338 Ligand Binding Site [chemical binding]; other site 768493006339 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 768493006340 nudix motif; other site 768493006341 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 768493006342 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 768493006343 probable active site [active] 768493006344 isocitrate dehydrogenase; Validated; Region: PRK07362 768493006345 isocitrate dehydrogenase; Reviewed; Region: PRK07006 768493006346 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 768493006347 Autoinducer binding domain; Region: Autoind_bind; pfam03472 768493006348 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768493006349 DNA binding residues [nucleotide binding] 768493006350 dimerization interface [polypeptide binding]; other site 768493006351 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 768493006352 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 768493006353 TolA C-terminal; Region: TolA; pfam06519 768493006354 Domain of unknown function DUF20; Region: UPF0118; pfam01594 768493006355 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 768493006356 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493006357 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768493006358 Coenzyme A binding pocket [chemical binding]; other site 768493006359 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493006360 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768493006361 putative substrate translocation pore; other site 768493006362 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 768493006363 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768493006364 DNA binding site [nucleotide binding] 768493006365 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 768493006366 putative ligand binding site [chemical binding]; other site 768493006367 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 768493006368 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768493006369 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768493006370 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 768493006371 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 768493006372 Protein of unknown function; Region: DUF3658; pfam12395 768493006373 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 768493006374 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 768493006375 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 768493006376 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 768493006377 LysE type translocator; Region: LysE; cl00565 768493006378 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768493006379 DNA-binding site [nucleotide binding]; DNA binding site 768493006380 RNA-binding motif; other site 768493006381 short chain dehydrogenase; Provisional; Region: PRK06138 768493006382 classical (c) SDRs; Region: SDR_c; cd05233 768493006383 NAD(P) binding site [chemical binding]; other site 768493006384 active site 768493006385 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 768493006386 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 768493006387 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 768493006388 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 768493006389 NAD(P) binding site [chemical binding]; other site 768493006390 catalytic residues [active] 768493006391 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 768493006392 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768493006393 non-specific DNA binding site [nucleotide binding]; other site 768493006394 salt bridge; other site 768493006395 sequence-specific DNA binding site [nucleotide binding]; other site 768493006396 Cupin domain; Region: Cupin_2; pfam07883 768493006397 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 768493006398 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 768493006399 catalytic triad [active] 768493006400 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 768493006401 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 768493006402 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 768493006403 aromatic amino acid exporter; Provisional; Region: PRK11689 768493006404 EamA-like transporter family; Region: EamA; pfam00892 768493006405 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 768493006406 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 768493006407 chorismate mutase; Provisional; Region: PRK08055 768493006408 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 768493006409 Beta-lactamase; Region: Beta-lactamase; pfam00144 768493006410 N-formylglutamate amidohydrolase; Region: FGase; cl01522 768493006411 imidazolonepropionase; Validated; Region: PRK09356 768493006412 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 768493006413 active site 768493006414 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 768493006415 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768493006416 DNA-binding site [nucleotide binding]; DNA binding site 768493006417 UTRA domain; Region: UTRA; pfam07702 768493006418 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 768493006419 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 768493006420 active site 768493006421 HutD; Region: HutD; pfam05962 768493006422 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 768493006423 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 768493006424 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 768493006425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493006426 dimer interface [polypeptide binding]; other site 768493006427 conserved gate region; other site 768493006428 putative PBP binding loops; other site 768493006429 ABC-ATPase subunit interface; other site 768493006430 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 768493006431 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 768493006432 Walker A/P-loop; other site 768493006433 ATP binding site [chemical binding]; other site 768493006434 Q-loop/lid; other site 768493006435 ABC transporter signature motif; other site 768493006436 Walker B; other site 768493006437 D-loop; other site 768493006438 H-loop/switch region; other site 768493006439 histidinol-phosphate aminotransferase; Provisional; Region: PRK05166 768493006440 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768493006441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493006442 homodimer interface [polypeptide binding]; other site 768493006443 catalytic residue [active] 768493006444 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 768493006445 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 768493006446 phosphate binding site [ion binding]; other site 768493006447 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768493006448 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768493006449 DNA binding site [nucleotide binding] 768493006450 domain linker motif; other site 768493006451 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 768493006452 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 768493006453 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 768493006454 substrate binding [chemical binding]; other site 768493006455 active site 768493006456 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 768493006457 galactoside permease; Reviewed; Region: lacY; PRK09528 768493006458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493006459 putative substrate translocation pore; other site 768493006460 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768493006461 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 768493006462 NAD(P) binding site [chemical binding]; other site 768493006463 active site 768493006464 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 768493006465 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 768493006466 NAD binding site [chemical binding]; other site 768493006467 dimerization interface [polypeptide binding]; other site 768493006468 product binding site; other site 768493006469 substrate binding site [chemical binding]; other site 768493006470 zinc binding site [ion binding]; other site 768493006471 catalytic residues [active] 768493006472 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 768493006473 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 768493006474 Walker A/P-loop; other site 768493006475 ATP binding site [chemical binding]; other site 768493006476 Q-loop/lid; other site 768493006477 ABC transporter signature motif; other site 768493006478 Walker B; other site 768493006479 D-loop; other site 768493006480 H-loop/switch region; other site 768493006481 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 768493006482 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493006483 dimer interface [polypeptide binding]; other site 768493006484 conserved gate region; other site 768493006485 putative PBP binding loops; other site 768493006486 ABC-ATPase subunit interface; other site 768493006487 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 768493006488 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768493006489 substrate binding pocket [chemical binding]; other site 768493006490 membrane-bound complex binding site; other site 768493006491 hinge residues; other site 768493006492 metabolite-proton symporter; Region: 2A0106; TIGR00883 768493006493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493006494 putative substrate translocation pore; other site 768493006495 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768493006496 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768493006497 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493006498 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493006499 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 768493006500 putative effector binding pocket; other site 768493006501 putative dimerization interface [polypeptide binding]; other site 768493006502 hypothetical protein; Provisional; Region: PRK08204 768493006503 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 768493006504 active site 768493006505 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 768493006506 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 768493006507 active site 768493006508 substrate-binding site [chemical binding]; other site 768493006509 metal-binding site [ion binding] 768493006510 ATP binding site [chemical binding]; other site 768493006511 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 768493006512 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 768493006513 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 768493006514 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 768493006515 Spore Coat Protein U domain; Region: SCPU; pfam05229 768493006516 Uncharacterized secreted protein [Function unknown]; Region: COG5430 768493006517 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 768493006518 PapC N-terminal domain; Region: PapC_N; pfam13954 768493006519 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 768493006520 PapC C-terminal domain; Region: PapC_C; pfam13953 768493006521 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 768493006522 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 768493006523 Spore Coat Protein U domain; Region: SCPU; pfam05229 768493006524 Spore Coat Protein U domain; Region: SCPU; pfam05229 768493006525 Spore Coat Protein U domain; Region: SCPU; pfam05229 768493006526 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 768493006527 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493006528 S-adenosylmethionine binding site [chemical binding]; other site 768493006529 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 768493006530 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 768493006531 mce related protein; Region: MCE; pfam02470 768493006532 mce related protein; Region: MCE; pfam02470 768493006533 mce related protein; Region: MCE; pfam02470 768493006534 mce related protein; Region: MCE; pfam02470 768493006535 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 768493006536 mce related protein; Region: MCE; pfam02470 768493006537 mce related protein; Region: MCE; pfam02470 768493006538 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 768493006539 Paraquat-inducible protein A; Region: PqiA; pfam04403 768493006540 Paraquat-inducible protein A; Region: PqiA; pfam04403 768493006541 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 768493006542 GAF domain; Region: GAF_2; pfam13185 768493006543 ProP expression regulator; Provisional; Region: PRK04950 768493006544 ProQ/FINO family; Region: ProQ; pfam04352 768493006545 putative RNA binding sites [nucleotide binding]; other site 768493006546 carboxy-terminal protease; Provisional; Region: PRK11186 768493006547 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 768493006548 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 768493006549 protein binding site [polypeptide binding]; other site 768493006550 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 768493006551 Catalytic dyad [active] 768493006552 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 768493006553 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 768493006554 heat shock protein HtpX; Provisional; Region: PRK05457 768493006555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493006556 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768493006557 putative substrate translocation pore; other site 768493006558 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 768493006559 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 768493006560 Bacterial transcriptional regulator; Region: IclR; pfam01614 768493006561 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 768493006562 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 768493006563 inner membrane protein; Provisional; Region: PRK11648 768493006564 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 768493006565 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768493006566 motif II; other site 768493006567 YniB-like protein; Region: YniB; pfam14002 768493006568 Fructosamine kinase; Region: Fructosamin_kin; pfam03881 768493006569 Phosphotransferase enzyme family; Region: APH; pfam01636 768493006570 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493006571 Coenzyme A binding pocket [chemical binding]; other site 768493006572 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 768493006573 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768493006574 ABC-ATPase subunit interface; other site 768493006575 dimer interface [polypeptide binding]; other site 768493006576 putative PBP binding regions; other site 768493006577 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 768493006578 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768493006579 ABC-ATPase subunit interface; other site 768493006580 dimer interface [polypeptide binding]; other site 768493006581 putative PBP binding regions; other site 768493006582 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 768493006583 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 768493006584 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 768493006585 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 768493006586 metal binding site [ion binding]; metal-binding site 768493006587 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 768493006588 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 768493006589 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768493006590 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768493006591 catalytic residue [active] 768493006592 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 768493006593 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 768493006594 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 768493006595 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 768493006596 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768493006597 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768493006598 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 768493006599 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 768493006600 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 768493006601 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 768493006602 intersubunit interface [polypeptide binding]; other site 768493006603 inner membrane protein; Provisional; Region: PRK10995 768493006604 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 768493006605 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 768493006606 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 768493006607 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 768493006608 active site 768493006609 dimer interface [polypeptide binding]; other site 768493006610 motif 1; other site 768493006611 motif 2; other site 768493006612 motif 3; other site 768493006613 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 768493006614 anticodon binding site; other site 768493006615 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 768493006616 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 768493006617 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 768493006618 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 768493006619 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 768493006620 23S rRNA binding site [nucleotide binding]; other site 768493006621 L21 binding site [polypeptide binding]; other site 768493006622 L13 binding site [polypeptide binding]; other site 768493006623 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 768493006624 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 768493006625 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 768493006626 dimer interface [polypeptide binding]; other site 768493006627 motif 1; other site 768493006628 active site 768493006629 motif 2; other site 768493006630 motif 3; other site 768493006631 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 768493006632 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 768493006633 putative tRNA-binding site [nucleotide binding]; other site 768493006634 B3/4 domain; Region: B3_4; pfam03483 768493006635 tRNA synthetase B5 domain; Region: B5; smart00874 768493006636 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 768493006637 dimer interface [polypeptide binding]; other site 768493006638 motif 1; other site 768493006639 motif 3; other site 768493006640 motif 2; other site 768493006641 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 768493006642 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 768493006643 IHF dimer interface [polypeptide binding]; other site 768493006644 IHF - DNA interface [nucleotide binding]; other site 768493006645 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 768493006646 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 768493006647 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768493006648 dimer interface [polypeptide binding]; other site 768493006649 putative PBP binding regions; other site 768493006650 ABC-ATPase subunit interface; other site 768493006651 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 768493006652 catalytic residues [active] 768493006653 dimer interface [polypeptide binding]; other site 768493006654 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 768493006655 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768493006656 Walker A/P-loop; other site 768493006657 ATP binding site [chemical binding]; other site 768493006658 Q-loop/lid; other site 768493006659 ABC transporter signature motif; other site 768493006660 Walker B; other site 768493006661 D-loop; other site 768493006662 H-loop/switch region; other site 768493006663 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 768493006664 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 768493006665 inhibitor-cofactor binding pocket; inhibition site 768493006666 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493006667 catalytic residue [active] 768493006668 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 768493006669 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 768493006670 Ligand binding site; other site 768493006671 Putative Catalytic site; other site 768493006672 DXD motif; other site 768493006673 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 768493006674 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 768493006675 active site 768493006676 substrate binding site [chemical binding]; other site 768493006677 cosubstrate binding site; other site 768493006678 catalytic site [active] 768493006679 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 768493006680 active site 768493006681 hexamer interface [polypeptide binding]; other site 768493006682 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 768493006683 NAD binding site [chemical binding]; other site 768493006684 substrate binding site [chemical binding]; other site 768493006685 active site 768493006686 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 768493006687 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 768493006688 putative active site [active] 768493006689 putative catalytic site [active] 768493006690 putative Zn binding site [ion binding]; other site 768493006691 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 768493006692 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 768493006693 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 768493006694 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 768493006695 NlpC/P60 family; Region: NLPC_P60; pfam00877 768493006696 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 768493006697 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 768493006698 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 768493006699 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768493006700 Uncharacterized conserved protein [Function unknown]; Region: COG0397 768493006701 hypothetical protein; Validated; Region: PRK00029 768493006702 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 768493006703 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768493006704 Walker A/P-loop; other site 768493006705 ATP binding site [chemical binding]; other site 768493006706 Q-loop/lid; other site 768493006707 ABC transporter signature motif; other site 768493006708 Walker B; other site 768493006709 D-loop; other site 768493006710 H-loop/switch region; other site 768493006711 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 768493006712 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768493006713 ABC-ATPase subunit interface; other site 768493006714 dimer interface [polypeptide binding]; other site 768493006715 putative PBP binding regions; other site 768493006716 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 768493006717 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 768493006718 putative hemin binding site; other site 768493006719 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 768493006720 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 768493006721 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 768493006722 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 768493006723 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768493006724 N-terminal plug; other site 768493006725 ligand-binding site [chemical binding]; other site 768493006726 Hemin uptake protein hemP; Region: hemP; pfam10636 768493006727 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 768493006728 catalytic residues [active] 768493006729 dimer interface [polypeptide binding]; other site 768493006730 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 768493006731 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 768493006732 PEP synthetase regulatory protein; Provisional; Region: PRK05339 768493006733 phosphoenolpyruvate synthase; Validated; Region: PRK06464 768493006734 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 768493006735 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 768493006736 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 768493006737 putative inner membrane protein; Provisional; Region: PRK10983 768493006738 Domain of unknown function DUF20; Region: UPF0118; pfam01594 768493006739 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 768493006740 FAD binding domain; Region: FAD_binding_4; pfam01565 768493006741 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 768493006742 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 768493006743 CoenzymeA binding site [chemical binding]; other site 768493006744 subunit interaction site [polypeptide binding]; other site 768493006745 PHB binding site; other site 768493006746 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 768493006747 putative ABC transporter; Region: ycf24; CHL00085 768493006748 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 768493006749 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 768493006750 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 768493006751 Walker A/P-loop; other site 768493006752 ATP binding site [chemical binding]; other site 768493006753 Q-loop/lid; other site 768493006754 ABC transporter signature motif; other site 768493006755 Walker B; other site 768493006756 D-loop; other site 768493006757 H-loop/switch region; other site 768493006758 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 768493006759 FeS assembly protein SufD; Region: sufD; TIGR01981 768493006760 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 768493006761 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 768493006762 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768493006763 catalytic residue [active] 768493006764 cysteine desufuration protein SufE; Provisional; Region: PRK09296 768493006765 L,D-transpeptidase; Provisional; Region: PRK10190 768493006766 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768493006767 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 768493006768 murein lipoprotein; Provisional; Region: PRK15396 768493006769 pyruvate kinase; Provisional; Region: PRK09206 768493006770 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 768493006771 domain interfaces; other site 768493006772 active site 768493006773 Cupin domain; Region: Cupin_2; cl17218 768493006774 multidrug efflux protein; Reviewed; Region: PRK01766 768493006775 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 768493006776 cation binding site [ion binding]; other site 768493006777 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 768493006778 Lumazine binding domain; Region: Lum_binding; pfam00677 768493006779 Lumazine binding domain; Region: Lum_binding; pfam00677 768493006780 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 768493006781 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 768493006782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 768493006783 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493006784 S-adenosylmethionine binding site [chemical binding]; other site 768493006785 putative transporter; Provisional; Region: PRK11043 768493006786 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493006787 putative substrate translocation pore; other site 768493006788 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 768493006789 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493006790 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768493006791 dimerization interface [polypeptide binding]; other site 768493006792 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 768493006793 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768493006794 DNA binding site [nucleotide binding] 768493006795 domain linker motif; other site 768493006796 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 768493006797 dimerization interface [polypeptide binding]; other site 768493006798 ligand binding site [chemical binding]; other site 768493006799 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 768493006800 NlpC/P60 family; Region: NLPC_P60; pfam00877 768493006801 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 768493006802 putative GSH binding site [chemical binding]; other site 768493006803 catalytic residues [active] 768493006804 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 768493006805 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 768493006806 dimer interface [polypeptide binding]; other site 768493006807 catalytic site [active] 768493006808 putative active site [active] 768493006809 putative substrate binding site [chemical binding]; other site 768493006810 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768493006811 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 768493006812 dimer interface [polypeptide binding]; other site 768493006813 active site 768493006814 metal binding site [ion binding]; metal-binding site 768493006815 glutathione binding site [chemical binding]; other site 768493006816 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 768493006817 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 768493006818 active site 768493006819 metal binding site [ion binding]; metal-binding site 768493006820 nudix motif; other site 768493006821 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 768493006822 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 768493006823 FMN binding site [chemical binding]; other site 768493006824 active site 768493006825 substrate binding site [chemical binding]; other site 768493006826 catalytic residue [active] 768493006827 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768493006828 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768493006829 putative metal dependent hydrolase; Provisional; Region: PRK11598 768493006830 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 768493006831 Sulfatase; Region: Sulfatase; pfam00884 768493006832 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 768493006833 NADH(P)-binding; Region: NAD_binding_10; pfam13460 768493006834 NAD binding site [chemical binding]; other site 768493006835 substrate binding site [chemical binding]; other site 768493006836 putative active site [active] 768493006837 transcriptional regulator; Provisional; Region: PRK10632 768493006838 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493006839 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768493006840 putative effector binding pocket; other site 768493006841 dimerization interface [polypeptide binding]; other site 768493006842 Predicted Fe-S protein [General function prediction only]; Region: COG3313 768493006843 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768493006844 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768493006845 active site 768493006846 catalytic tetrad [active] 768493006847 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 768493006848 nucleophilic elbow; other site 768493006849 catalytic triad; other site 768493006850 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 768493006851 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 768493006852 E-class dimer interface [polypeptide binding]; other site 768493006853 P-class dimer interface [polypeptide binding]; other site 768493006854 active site 768493006855 Cu2+ binding site [ion binding]; other site 768493006856 Zn2+ binding site [ion binding]; other site 768493006857 Fusaric acid resistance protein family; Region: FUSC; pfam04632 768493006858 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 768493006859 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 768493006860 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768493006861 HlyD family secretion protein; Region: HlyD_3; pfam13437 768493006862 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 768493006863 transcriptional regulator SlyA; Provisional; Region: PRK03573 768493006864 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 768493006865 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 768493006866 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 768493006867 lysozyme inhibitor; Provisional; Region: PRK11372 768493006868 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 768493006869 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 768493006870 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 768493006871 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 768493006872 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 768493006873 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 768493006874 active site 768493006875 HIGH motif; other site 768493006876 dimer interface [polypeptide binding]; other site 768493006877 KMSKS motif; other site 768493006878 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768493006879 RNA binding surface [nucleotide binding]; other site 768493006880 pyridoxamine kinase; Validated; Region: PRK05756 768493006881 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 768493006882 dimer interface [polypeptide binding]; other site 768493006883 pyridoxal binding site [chemical binding]; other site 768493006884 ATP binding site [chemical binding]; other site 768493006885 glutathionine S-transferase; Provisional; Region: PRK10542 768493006886 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 768493006887 C-terminal domain interface [polypeptide binding]; other site 768493006888 GSH binding site (G-site) [chemical binding]; other site 768493006889 dimer interface [polypeptide binding]; other site 768493006890 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 768493006891 dimer interface [polypeptide binding]; other site 768493006892 N-terminal domain interface [polypeptide binding]; other site 768493006893 substrate binding pocket (H-site) [chemical binding]; other site 768493006894 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 768493006895 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 768493006896 dimer interface [polypeptide binding]; other site 768493006897 active site 768493006898 catalytic residue [active] 768493006899 YjbD family (DUF3811); Region: DUF3811; pfam11656 768493006900 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 768493006901 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768493006902 Zn2+ binding site [ion binding]; other site 768493006903 Mg2+ binding site [ion binding]; other site 768493006904 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 768493006905 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 768493006906 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 768493006907 homotrimer interaction site [polypeptide binding]; other site 768493006908 putative active site [active] 768493006909 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 768493006910 Cupin domain; Region: Cupin_2; cl17218 768493006911 MEKHLA domain; Region: MEKHLA; pfam08670 768493006912 benzoate transporter; Region: benE; TIGR00843 768493006913 Benzoate membrane transport protein; Region: BenE; pfam03594 768493006914 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 768493006915 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768493006916 non-specific DNA binding site [nucleotide binding]; other site 768493006917 salt bridge; other site 768493006918 sequence-specific DNA binding site [nucleotide binding]; other site 768493006919 Cupin domain; Region: Cupin_2; pfam07883 768493006920 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 768493006921 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 768493006922 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 768493006923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493006924 putative substrate translocation pore; other site 768493006925 POT family; Region: PTR2; pfam00854 768493006926 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 768493006927 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 768493006928 putative symporter YagG; Provisional; Region: PRK09669 768493006929 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768493006930 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493006931 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493006932 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768493006933 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493006934 putative symporter YagG; Provisional; Region: PRK09669 768493006935 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 768493006936 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 768493006937 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 768493006938 inhibitor binding site; inhibition site 768493006939 active site 768493006940 endonuclease III; Provisional; Region: PRK10702 768493006941 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 768493006942 minor groove reading motif; other site 768493006943 helix-hairpin-helix signature motif; other site 768493006944 substrate binding pocket [chemical binding]; other site 768493006945 active site 768493006946 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 768493006947 electron transport complex RsxE subunit; Provisional; Region: PRK12405 768493006948 electron transport complex protein RnfG; Validated; Region: PRK01908 768493006949 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 768493006950 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 768493006951 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493006952 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 768493006953 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 768493006954 SLBB domain; Region: SLBB; pfam10531 768493006955 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768493006956 ferredoxin; Provisional; Region: PRK08764 768493006957 Putative Fe-S cluster; Region: FeS; cl17515 768493006958 4Fe-4S binding domain; Region: Fer4; pfam00037 768493006959 electron transport complex protein RsxA; Provisional; Region: PRK05151 768493006960 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 768493006961 L-arabinose isomerase; Provisional; Region: PRK02929 768493006962 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 768493006963 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 768493006964 trimer interface [polypeptide binding]; other site 768493006965 putative substrate binding site [chemical binding]; other site 768493006966 putative metal binding site [ion binding]; other site 768493006967 ribulokinase; Provisional; Region: PRK04123 768493006968 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 768493006969 N- and C-terminal domain interface [polypeptide binding]; other site 768493006970 active site 768493006971 MgATP binding site [chemical binding]; other site 768493006972 catalytic site [active] 768493006973 metal binding site [ion binding]; metal-binding site 768493006974 carbohydrate binding site [chemical binding]; other site 768493006975 homodimer interface [polypeptide binding]; other site 768493006976 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 768493006977 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 768493006978 ligand binding site [chemical binding]; other site 768493006979 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 768493006980 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768493006981 Walker A/P-loop; other site 768493006982 ATP binding site [chemical binding]; other site 768493006983 Q-loop/lid; other site 768493006984 ABC transporter signature motif; other site 768493006985 Walker B; other site 768493006986 D-loop; other site 768493006987 H-loop/switch region; other site 768493006988 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768493006989 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768493006990 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768493006991 TM-ABC transporter signature motif; other site 768493006992 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 768493006993 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768493006994 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493006995 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493006996 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 768493006997 substrate binding pocket [chemical binding]; other site 768493006998 substrate-Mg2+ binding site; other site 768493006999 aspartate-rich region 1; other site 768493007000 aspartate-rich region 2; other site 768493007001 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493007002 S-adenosylmethionine binding site [chemical binding]; other site 768493007003 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 768493007004 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 768493007005 TPP-binding site; other site 768493007006 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 768493007007 PYR/PP interface [polypeptide binding]; other site 768493007008 dimer interface [polypeptide binding]; other site 768493007009 TPP binding site [chemical binding]; other site 768493007010 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768493007011 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 768493007012 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 768493007013 active site 768493007014 metal binding site [ion binding]; metal-binding site 768493007015 nudix motif; other site 768493007016 putative oxidoreductase; Provisional; Region: PRK11579 768493007017 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768493007018 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 768493007019 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 768493007020 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 768493007021 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 768493007022 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 768493007023 active site 768493007024 purine riboside binding site [chemical binding]; other site 768493007025 AAA domain; Region: AAA_17; pfam13207 768493007026 AAA domain; Region: AAA_18; pfam13238 768493007027 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 768493007028 active site 768493007029 phosphorylation site [posttranslational modification] 768493007030 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 768493007031 intersubunit interface [polypeptide binding]; other site 768493007032 active site 768493007033 zinc binding site [ion binding]; other site 768493007034 Na+ binding site [ion binding]; other site 768493007035 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 768493007036 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 768493007037 active site 768493007038 P-loop; other site 768493007039 phosphorylation site [posttranslational modification] 768493007040 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 768493007041 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 768493007042 active site 768493007043 ADP/pyrophosphate binding site [chemical binding]; other site 768493007044 dimerization interface [polypeptide binding]; other site 768493007045 allosteric effector site; other site 768493007046 fructose-1,6-bisphosphate binding site; other site 768493007047 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 768493007048 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 768493007049 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 768493007050 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 768493007051 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 768493007052 dimer interface [polypeptide binding]; other site 768493007053 ADP-ribose binding site [chemical binding]; other site 768493007054 active site 768493007055 nudix motif; other site 768493007056 metal binding site [ion binding]; metal-binding site 768493007057 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 768493007058 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 768493007059 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768493007060 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493007061 homodimer interface [polypeptide binding]; other site 768493007062 catalytic residue [active] 768493007063 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 768493007064 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 768493007065 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768493007066 active site turn [active] 768493007067 phosphorylation site [posttranslational modification] 768493007068 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 768493007069 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768493007070 DNA binding site [nucleotide binding] 768493007071 domain linker motif; other site 768493007072 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 768493007073 putative dimerization interface [polypeptide binding]; other site 768493007074 putative ligand binding site [chemical binding]; other site 768493007075 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768493007076 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493007077 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768493007078 dimerization interface [polypeptide binding]; other site 768493007079 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 768493007080 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 768493007081 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493007082 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493007083 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 768493007084 putative effector binding pocket; other site 768493007085 putative dimerization interface [polypeptide binding]; other site 768493007086 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 768493007087 Beta-lactamase; Region: Beta-lactamase; pfam00144 768493007088 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 768493007089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 768493007090 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 768493007091 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 768493007092 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 768493007093 fumarate hydratase; Reviewed; Region: fumC; PRK00485 768493007094 Class II fumarases; Region: Fumarase_classII; cd01362 768493007095 active site 768493007096 tetramer interface [polypeptide binding]; other site 768493007097 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 768493007098 putative catalytic residues [active] 768493007099 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493007100 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493007101 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768493007102 putative effector binding pocket; other site 768493007103 dimerization interface [polypeptide binding]; other site 768493007104 Predicted transcriptional regulator [Transcription]; Region: COG2378 768493007105 HTH domain; Region: HTH_11; pfam08279 768493007106 WYL domain; Region: WYL; pfam13280 768493007107 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768493007108 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 768493007109 putative dimer interface [polypeptide binding]; other site 768493007110 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 768493007111 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768493007112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493007113 putative substrate translocation pore; other site 768493007114 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 768493007115 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493007116 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 768493007117 dimerization interface [polypeptide binding]; other site 768493007118 substrate binding pocket [chemical binding]; other site 768493007119 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 768493007120 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 768493007121 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768493007122 nucleotide binding site [chemical binding]; other site 768493007123 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 768493007124 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 768493007125 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 768493007126 Cl- selectivity filter; other site 768493007127 Cl- binding residues [ion binding]; other site 768493007128 pore gating glutamate residue; other site 768493007129 dimer interface [polypeptide binding]; other site 768493007130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493007131 putative substrate translocation pore; other site 768493007132 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 768493007133 hypothetical protein; Provisional; Region: PRK13659 768493007134 hypothetical protein; Provisional; Region: PRK02237 768493007135 malonic semialdehyde reductase; Provisional; Region: PRK10538 768493007136 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 768493007137 putative NAD(P) binding site [chemical binding]; other site 768493007138 homodimer interface [polypeptide binding]; other site 768493007139 homotetramer interface [polypeptide binding]; other site 768493007140 active site 768493007141 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768493007142 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 768493007143 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768493007144 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768493007145 active site 768493007146 catalytic tetrad [active] 768493007147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493007148 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768493007149 putative substrate translocation pore; other site 768493007150 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 768493007151 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768493007152 Walker A/P-loop; other site 768493007153 ATP binding site [chemical binding]; other site 768493007154 Q-loop/lid; other site 768493007155 ABC transporter signature motif; other site 768493007156 Walker B; other site 768493007157 D-loop; other site 768493007158 H-loop/switch region; other site 768493007159 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 768493007160 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768493007161 substrate binding site [chemical binding]; other site 768493007162 ATP binding site [chemical binding]; other site 768493007163 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 768493007164 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493007165 dimer interface [polypeptide binding]; other site 768493007166 conserved gate region; other site 768493007167 putative PBP binding loops; other site 768493007168 ABC-ATPase subunit interface; other site 768493007169 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493007170 dimer interface [polypeptide binding]; other site 768493007171 conserved gate region; other site 768493007172 putative PBP binding loops; other site 768493007173 ABC-ATPase subunit interface; other site 768493007174 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 768493007175 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 768493007176 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 768493007177 non-specific DNA interactions [nucleotide binding]; other site 768493007178 DNA binding site [nucleotide binding] 768493007179 sequence specific DNA binding site [nucleotide binding]; other site 768493007180 putative cAMP binding site [chemical binding]; other site 768493007181 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 768493007182 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768493007183 nucleotide binding site [chemical binding]; other site 768493007184 Chitin binding domain; Region: Chitin_bind_3; pfam03067 768493007185 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 768493007186 Interdomain contacts; other site 768493007187 Cytokine receptor motif; other site 768493007188 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 768493007189 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 768493007190 Interdomain contacts; other site 768493007191 Cytokine receptor motif; other site 768493007192 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 768493007193 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 768493007194 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 768493007195 putative active site [active] 768493007196 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 768493007197 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 768493007198 Interdomain contacts; other site 768493007199 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 768493007200 guanine deaminase; Provisional; Region: PRK09228 768493007201 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 768493007202 active site 768493007203 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 768493007204 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768493007205 catalytic loop [active] 768493007206 iron binding site [ion binding]; other site 768493007207 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 768493007208 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 768493007209 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 768493007210 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 768493007211 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768493007212 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 768493007213 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 768493007214 XdhC Rossmann domain; Region: XdhC_C; pfam13478 768493007215 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 768493007216 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 768493007217 NAD binding site [chemical binding]; other site 768493007218 sugar binding site [chemical binding]; other site 768493007219 divalent metal binding site [ion binding]; other site 768493007220 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 768493007221 dimer interface [polypeptide binding]; other site 768493007222 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768493007223 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 768493007224 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768493007225 active site turn [active] 768493007226 phosphorylation site [posttranslational modification] 768493007227 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 768493007228 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768493007229 DNA-binding site [nucleotide binding]; DNA binding site 768493007230 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 768493007231 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 768493007232 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 768493007233 Ca binding site [ion binding]; other site 768493007234 active site 768493007235 catalytic site [active] 768493007236 Cytochrome c; Region: Cytochrom_C; pfam00034 768493007237 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 768493007238 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 768493007239 active site 768493007240 Zn binding site [ion binding]; other site 768493007241 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 768493007242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493007243 putative substrate translocation pore; other site 768493007244 Isochorismatase family; Region: Isochorismatase; pfam00857 768493007245 N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015 768493007246 catalytic triad [active] 768493007247 substrate binding site [chemical binding]; other site 768493007248 domain interfaces; other site 768493007249 conserved cis-peptide bond; other site 768493007250 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 768493007251 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768493007252 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 768493007253 catalytic site [active] 768493007254 hypothetical protein; Provisional; Region: PRK06847 768493007255 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 768493007256 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 768493007257 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768493007258 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 768493007259 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 768493007260 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 768493007261 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 768493007262 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768493007263 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 768493007264 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 768493007265 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768493007266 Cytochrome c; Region: Cytochrom_C; pfam00034 768493007267 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768493007268 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768493007269 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 768493007270 HlyD family secretion protein; Region: HlyD; pfam00529 768493007271 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768493007272 HlyD family secretion protein; Region: HlyD_3; pfam13437 768493007273 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 768493007274 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 768493007275 putative active site [active] 768493007276 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768493007277 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768493007278 Walker A/P-loop; other site 768493007279 ATP binding site [chemical binding]; other site 768493007280 Q-loop/lid; other site 768493007281 ABC transporter signature motif; other site 768493007282 Walker B; other site 768493007283 D-loop; other site 768493007284 H-loop/switch region; other site 768493007285 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 768493007286 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 768493007287 homodimer interface [polypeptide binding]; other site 768493007288 homotetramer interface [polypeptide binding]; other site 768493007289 active site pocket [active] 768493007290 cleavage site 768493007291 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 768493007292 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 768493007293 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768493007294 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 768493007295 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768493007296 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768493007297 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 768493007298 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768493007299 catalytic loop [active] 768493007300 iron binding site [ion binding]; other site 768493007301 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 768493007302 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768493007303 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768493007304 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 768493007305 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 768493007306 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768493007307 active site turn [active] 768493007308 phosphorylation site [posttranslational modification] 768493007309 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768493007310 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 768493007311 HPr interaction site; other site 768493007312 glycerol kinase (GK) interaction site [polypeptide binding]; other site 768493007313 active site 768493007314 phosphorylation site [posttranslational modification] 768493007315 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 768493007316 beta-galactosidase; Region: BGL; TIGR03356 768493007317 transcriptional antiterminator BglG; Provisional; Region: PRK09772 768493007318 CAT RNA binding domain; Region: CAT_RBD; smart01061 768493007319 PRD domain; Region: PRD; pfam00874 768493007320 PRD domain; Region: PRD; pfam00874 768493007321 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 768493007322 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493007323 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 768493007324 putative dimerization interface [polypeptide binding]; other site 768493007325 putative substrate binding pocket [chemical binding]; other site 768493007326 Chromate transporter; Region: Chromate_transp; pfam02417 768493007327 Chromate transporter; Region: Chromate_transp; pfam02417 768493007328 Protease inhibitor Inh; Region: Inh; pfam02974 768493007329 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 768493007330 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 768493007331 classical (c) SDRs; Region: SDR_c; cd05233 768493007332 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 768493007333 NAD(P) binding site [chemical binding]; other site 768493007334 active site 768493007335 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768493007336 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768493007337 DNA binding site [nucleotide binding] 768493007338 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 768493007339 putative ligand binding site [chemical binding]; other site 768493007340 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 768493007341 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 768493007342 putative active site [active] 768493007343 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768493007344 EamA-like transporter family; Region: EamA; pfam00892 768493007345 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768493007346 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493007347 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 768493007348 active site 768493007349 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 768493007350 NIPSNAP; Region: NIPSNAP; pfam07978 768493007351 drug efflux system protein MdtG; Provisional; Region: PRK09874 768493007352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493007353 putative substrate translocation pore; other site 768493007354 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 768493007355 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 768493007356 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768493007357 active site 768493007358 motif I; other site 768493007359 motif II; other site 768493007360 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 768493007361 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 768493007362 Coenzyme A binding pocket [chemical binding]; other site 768493007363 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 768493007364 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768493007365 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 768493007366 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 768493007367 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 768493007368 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 768493007369 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 768493007370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493007371 dimer interface [polypeptide binding]; other site 768493007372 conserved gate region; other site 768493007373 putative PBP binding loops; other site 768493007374 ABC-ATPase subunit interface; other site 768493007375 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 768493007376 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 768493007377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493007378 dimer interface [polypeptide binding]; other site 768493007379 conserved gate region; other site 768493007380 putative PBP binding loops; other site 768493007381 ABC-ATPase subunit interface; other site 768493007382 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 768493007383 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768493007384 Walker A/P-loop; other site 768493007385 ATP binding site [chemical binding]; other site 768493007386 Q-loop/lid; other site 768493007387 ABC transporter signature motif; other site 768493007388 Walker B; other site 768493007389 D-loop; other site 768493007390 H-loop/switch region; other site 768493007391 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768493007392 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 768493007393 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768493007394 Walker A/P-loop; other site 768493007395 ATP binding site [chemical binding]; other site 768493007396 Q-loop/lid; other site 768493007397 ABC transporter signature motif; other site 768493007398 Walker B; other site 768493007399 D-loop; other site 768493007400 H-loop/switch region; other site 768493007401 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 768493007402 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 768493007403 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 768493007404 active site 768493007405 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 768493007406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493007407 putative substrate translocation pore; other site 768493007408 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493007409 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493007410 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768493007411 dimerization interface [polypeptide binding]; other site 768493007412 penicillin-binding protein 2; Provisional; Region: PRK10795 768493007413 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 768493007414 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 768493007415 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 768493007416 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 768493007417 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 768493007418 lipoprotein; Provisional; Region: PRK10540 768493007419 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768493007420 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493007421 Coenzyme A binding pocket [chemical binding]; other site 768493007422 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 768493007423 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 768493007424 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 768493007425 Walker A/P-loop; other site 768493007426 ATP binding site [chemical binding]; other site 768493007427 Q-loop/lid; other site 768493007428 ABC transporter signature motif; other site 768493007429 Walker B; other site 768493007430 D-loop; other site 768493007431 H-loop/switch region; other site 768493007432 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768493007433 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493007434 dimer interface [polypeptide binding]; other site 768493007435 conserved gate region; other site 768493007436 putative PBP binding loops; other site 768493007437 ABC-ATPase subunit interface; other site 768493007438 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768493007439 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768493007440 substrate binding pocket [chemical binding]; other site 768493007441 membrane-bound complex binding site; other site 768493007442 hinge residues; other site 768493007443 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 768493007444 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 768493007445 active site 768493007446 non-prolyl cis peptide bond; other site 768493007447 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 768493007448 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493007449 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493007450 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 768493007451 putative effector binding pocket; other site 768493007452 putative dimerization interface [polypeptide binding]; other site 768493007453 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 768493007454 Beta-lactamase; Region: Beta-lactamase; pfam00144 768493007455 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768493007456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493007457 putative substrate translocation pore; other site 768493007458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493007459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493007460 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 768493007461 RibD C-terminal domain; Region: RibD_C; cl17279 768493007462 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 768493007463 Uncharacterized conserved protein [Function unknown]; Region: COG5276 768493007464 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 768493007465 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 768493007466 putative ligand binding site [chemical binding]; other site 768493007467 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 768493007468 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 768493007469 putative active site [active] 768493007470 metal binding site [ion binding]; metal-binding site 768493007471 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 768493007472 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 768493007473 putative NADP binding site [chemical binding]; other site 768493007474 putative substrate binding site [chemical binding]; other site 768493007475 active site 768493007476 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768493007477 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768493007478 Pirin; Region: Pirin; pfam02678 768493007479 Pirin-related protein [General function prediction only]; Region: COG1741 768493007480 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 768493007481 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768493007482 Predicted transcriptional regulators [Transcription]; Region: COG1733 768493007483 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 768493007484 NmrA-like family; Region: NmrA; pfam05368 768493007485 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 768493007486 NADP binding site [chemical binding]; other site 768493007487 active site 768493007488 regulatory binding site [polypeptide binding]; other site 768493007489 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 768493007490 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 768493007491 putative NAD(P) binding site [chemical binding]; other site 768493007492 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493007493 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493007494 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768493007495 putative effector binding pocket; other site 768493007496 dimerization interface [polypeptide binding]; other site 768493007497 Protein of unknown function (DUF419); Region: DUF419; cl15265 768493007498 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 768493007499 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 768493007500 Walker A/P-loop; other site 768493007501 ATP binding site [chemical binding]; other site 768493007502 Q-loop/lid; other site 768493007503 ABC transporter signature motif; other site 768493007504 Walker B; other site 768493007505 D-loop; other site 768493007506 H-loop/switch region; other site 768493007507 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 768493007508 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 768493007509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493007510 dimer interface [polypeptide binding]; other site 768493007511 conserved gate region; other site 768493007512 ABC-ATPase subunit interface; other site 768493007513 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 768493007514 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493007515 dimer interface [polypeptide binding]; other site 768493007516 conserved gate region; other site 768493007517 putative PBP binding loops; other site 768493007518 ABC-ATPase subunit interface; other site 768493007519 Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867 768493007520 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 768493007521 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 768493007522 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 768493007523 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 768493007524 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768493007525 active site turn [active] 768493007526 phosphorylation site [posttranslational modification] 768493007527 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 768493007528 trimer interface; other site 768493007529 sugar binding site [chemical binding]; other site 768493007530 lac repressor; Reviewed; Region: lacI; PRK09526 768493007531 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768493007532 DNA binding site [nucleotide binding] 768493007533 domain linker motif; other site 768493007534 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 768493007535 ligand binding site [chemical binding]; other site 768493007536 dimerization interface (open form) [polypeptide binding]; other site 768493007537 dimerization interface (closed form) [polypeptide binding]; other site 768493007538 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768493007539 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768493007540 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768493007541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493007542 putative substrate translocation pore; other site 768493007543 Alcaligenes xylosoxidans NreA and related domains; this domain family was previously known as part of DUF156; Region: NreA-like_DUF156; cd10154 768493007544 putative homodimer interface [polypeptide binding]; other site 768493007545 putative homotetramer interface [polypeptide binding]; other site 768493007546 putative metal binding site [ion binding]; other site 768493007547 putative homodimer-homodimer interface [polypeptide binding]; other site 768493007548 putative allosteric switch controlling residues; other site 768493007549 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 768493007550 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 768493007551 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 768493007552 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493007553 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 768493007554 hypothetical protein; Provisional; Region: PRK05208 768493007555 Rdx family; Region: Rdx; cl01407 768493007556 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 768493007557 Bacterial transcriptional regulator; Region: IclR; pfam01614 768493007558 PAS domain; Region: PAS; smart00091 768493007559 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768493007560 Walker A motif; other site 768493007561 ATP binding site [chemical binding]; other site 768493007562 Walker B motif; other site 768493007563 arginine finger; other site 768493007564 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768493007565 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768493007566 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768493007567 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 768493007568 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 768493007569 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 768493007570 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 768493007571 putative ligand binding site [chemical binding]; other site 768493007572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493007573 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768493007574 transcriptional regulator, ArgP family; Region: argP; TIGR03298 768493007575 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493007576 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768493007577 putative effector binding pocket; other site 768493007578 dimerization interface [polypeptide binding]; other site 768493007579 Amidinotransferase; Region: Amidinotransf; cl12043 768493007580 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 768493007581 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768493007582 substrate binding pocket [chemical binding]; other site 768493007583 membrane-bound complex binding site; other site 768493007584 hinge residues; other site 768493007585 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768493007586 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493007587 dimer interface [polypeptide binding]; other site 768493007588 conserved gate region; other site 768493007589 putative PBP binding loops; other site 768493007590 ABC-ATPase subunit interface; other site 768493007591 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768493007592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493007593 dimer interface [polypeptide binding]; other site 768493007594 conserved gate region; other site 768493007595 putative PBP binding loops; other site 768493007596 ABC-ATPase subunit interface; other site 768493007597 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768493007598 dimerization interface [polypeptide binding]; other site 768493007599 putative DNA binding site [nucleotide binding]; other site 768493007600 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 768493007601 putative Zn2+ binding site [ion binding]; other site 768493007602 AsnC family; Region: AsnC_trans_reg; pfam01037 768493007603 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 768493007604 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 768493007605 active site 768493007606 Zn binding site [ion binding]; other site 768493007607 Fic/DOC family; Region: Fic; pfam02661 768493007608 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 768493007609 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768493007610 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768493007611 Walker A/P-loop; other site 768493007612 ATP binding site [chemical binding]; other site 768493007613 Q-loop/lid; other site 768493007614 ABC transporter signature motif; other site 768493007615 Walker B; other site 768493007616 D-loop; other site 768493007617 H-loop/switch region; other site 768493007618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 768493007619 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 768493007620 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 768493007621 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 768493007622 NAD binding site [chemical binding]; other site 768493007623 substrate binding site [chemical binding]; other site 768493007624 catalytic Zn binding site [ion binding]; other site 768493007625 tetramer interface [polypeptide binding]; other site 768493007626 structural Zn binding site [ion binding]; other site 768493007627 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Region: ALDH_ACDHII_AcoD-like; cd07559 768493007628 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 768493007629 NAD(P) binding site [chemical binding]; other site 768493007630 catalytic residues [active] 768493007631 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 768493007632 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768493007633 Walker A motif; other site 768493007634 ATP binding site [chemical binding]; other site 768493007635 Walker B motif; other site 768493007636 arginine finger; other site 768493007637 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768493007638 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768493007639 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768493007640 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 768493007641 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 768493007642 NAD(P) binding site [chemical binding]; other site 768493007643 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768493007644 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768493007645 substrate binding pocket [chemical binding]; other site 768493007646 membrane-bound complex binding site; other site 768493007647 hinge residues; other site 768493007648 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493007649 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493007650 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768493007651 putative effector binding pocket; other site 768493007652 dimerization interface [polypeptide binding]; other site 768493007653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493007654 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768493007655 putative substrate translocation pore; other site 768493007656 PAS fold; Region: PAS_4; pfam08448 768493007657 PAS fold; Region: PAS_4; pfam08448 768493007658 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 768493007659 putative active site [active] 768493007660 heme pocket [chemical binding]; other site 768493007661 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768493007662 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768493007663 metal binding site [ion binding]; metal-binding site 768493007664 active site 768493007665 I-site; other site 768493007666 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768493007667 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 768493007668 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 768493007669 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 768493007670 Trp docking motif [polypeptide binding]; other site 768493007671 putative active site [active] 768493007672 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 768493007673 TAP-like protein; Region: Abhydrolase_4; pfam08386 768493007674 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493007675 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 768493007676 putative substrate binding pocket [chemical binding]; other site 768493007677 putative dimerization interface [polypeptide binding]; other site 768493007678 C factor cell-cell signaling protein; Provisional; Region: PRK09009 768493007679 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 768493007680 NADP binding site [chemical binding]; other site 768493007681 homodimer interface [polypeptide binding]; other site 768493007682 active site 768493007683 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 768493007684 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493007685 catalytic residue [active] 768493007686 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 768493007687 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768493007688 inhibitor-cofactor binding pocket; inhibition site 768493007689 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493007690 catalytic residue [active] 768493007691 Fucose-binding lectin II (PA-IIL); Region: PA-IIL; pfam07472 768493007692 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 768493007693 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 768493007694 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 768493007695 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 768493007696 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 768493007697 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768493007698 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768493007699 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768493007700 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768493007701 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768493007702 Surface antigen; Region: Bac_surface_Ag; pfam01103 768493007703 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 768493007704 active site 768493007705 catalytic residues [active] 768493007706 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768493007707 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768493007708 DNA binding site [nucleotide binding] 768493007709 domain linker motif; other site 768493007710 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 768493007711 ligand binding site [chemical binding]; other site 768493007712 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 768493007713 active site 768493007714 P-loop; other site 768493007715 phosphorylation site [posttranslational modification] 768493007716 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 768493007717 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 768493007718 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 768493007719 beta-galactosidase; Region: BGL; TIGR03356 768493007720 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 768493007721 methionine cluster; other site 768493007722 active site 768493007723 phosphorylation site [posttranslational modification] 768493007724 metal binding site [ion binding]; metal-binding site 768493007725 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 768493007726 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768493007727 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768493007728 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 768493007729 ABC transporter transmembrane region; Region: ABC_membrane_3; pfam13748 768493007730 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 768493007731 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768493007732 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 768493007733 E3 interaction surface; other site 768493007734 lipoyl attachment site [posttranslational modification]; other site 768493007735 e3 binding domain; Region: E3_binding; pfam02817 768493007736 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 768493007737 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 768493007738 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 768493007739 dimer interface [polypeptide binding]; other site 768493007740 TPP-binding site [chemical binding]; other site 768493007741 MarR family; Region: MarR; pfam01047 768493007742 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768493007743 FAD dependent oxidoreductase; Region: DAO; pfam01266 768493007744 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 768493007745 Predicted transcriptional regulators [Transcription]; Region: COG1733 768493007746 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 768493007747 short chain dehydrogenase; Provisional; Region: PRK06179 768493007748 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 768493007749 NADP binding site [chemical binding]; other site 768493007750 active site 768493007751 steroid binding site; other site 768493007752 YCII-related domain; Region: YCII; cl00999 768493007753 Predicted transcriptional regulators [Transcription]; Region: COG1733 768493007754 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 768493007755 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 768493007756 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 768493007757 NADP binding site [chemical binding]; other site 768493007758 MarR family; Region: MarR_2; cl17246 768493007759 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768493007760 EamA-like transporter family; Region: EamA; pfam00892 768493007761 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 768493007762 EamA-like transporter family; Region: EamA; pfam00892 768493007763 Nitroreductase [Energy production and conversion]; Region: NfnB; COG0778 768493007764 FMN binding site [chemical binding]; other site 768493007765 Winged helix-turn helix; Region: HTH_29; pfam13551 768493007766 Helix-turn-helix domain; Region: HTH_28; pfam13518 768493007767 Homeodomain-like domain; Region: HTH_32; pfam13565 768493007768 Integrase core domain; Region: rve; pfam00665 768493007769 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768493007770 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 768493007771 catalytic site [active] 768493007772 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 768493007773 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493007774 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 768493007775 dimerization interface [polypeptide binding]; other site 768493007776 substrate binding pocket [chemical binding]; other site 768493007777 SnoaL-like domain; Region: SnoaL_4; pfam13577 768493007778 Amidohydrolase; Region: Amidohydro_2; pfam04909 768493007779 Methyltransferase domain; Region: Methyltransf_23; pfam13489 768493007780 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 768493007781 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493007782 S-adenosylmethionine binding site [chemical binding]; other site 768493007783 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 768493007784 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 768493007785 putative ligand binding site [chemical binding]; other site 768493007786 NAD binding site [chemical binding]; other site 768493007787 catalytic site [active] 768493007788 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493007789 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493007790 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 768493007791 putative substrate binding pocket [chemical binding]; other site 768493007792 putative dimerization interface [polypeptide binding]; other site 768493007793 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 768493007794 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 768493007795 Predicted transcriptional regulators [Transcription]; Region: COG1733 768493007796 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 768493007797 Transcriptional regulators [Transcription]; Region: MarR; COG1846 768493007798 MarR family; Region: MarR_2; pfam12802 768493007799 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493007800 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768493007801 Coenzyme A binding pocket [chemical binding]; other site 768493007802 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 768493007803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493007804 putative substrate translocation pore; other site 768493007805 Uncharacterized conserved protein [Function unknown]; Region: COG4925 768493007806 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 768493007807 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 768493007808 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493007809 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493007810 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 768493007811 putative effector binding pocket; other site 768493007812 putative dimerization interface [polypeptide binding]; other site 768493007813 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493007814 transcriptional activator TtdR; Provisional; Region: PRK09801 768493007815 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768493007816 dimerization interface [polypeptide binding]; other site 768493007817 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 768493007818 active site 768493007819 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 768493007820 YheO-like PAS domain; Region: PAS_6; pfam08348 768493007821 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 768493007822 HTH domain; Region: HTH_22; pfam13309 768493007823 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 768493007824 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 768493007825 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 768493007826 NAD(P) binding site [chemical binding]; other site 768493007827 intracellular protease, PfpI family; Region: PfpI; TIGR01382 768493007828 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 768493007829 conserved cys residue [active] 768493007830 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 768493007831 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 768493007832 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 768493007833 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 768493007834 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768493007835 HlyD family secretion protein; Region: HlyD_3; pfam13437 768493007836 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 768493007837 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493007838 putative substrate translocation pore; other site 768493007839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493007840 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768493007841 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768493007842 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 768493007843 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 768493007844 active site 768493007845 homotetramer interface [polypeptide binding]; other site 768493007846 homodimer interface [polypeptide binding]; other site 768493007847 benzoate transporter; Region: benE; TIGR00843 768493007848 Benzoate membrane transport protein; Region: BenE; pfam03594 768493007849 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768493007850 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768493007851 DNA-binding site [nucleotide binding]; DNA binding site 768493007852 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768493007853 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493007854 homodimer interface [polypeptide binding]; other site 768493007855 catalytic residue [active] 768493007856 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768493007857 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768493007858 non-specific DNA binding site [nucleotide binding]; other site 768493007859 salt bridge; other site 768493007860 sequence-specific DNA binding site [nucleotide binding]; other site 768493007861 Cupin domain; Region: Cupin_2; cl17218 768493007862 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768493007863 EamA-like transporter family; Region: EamA; pfam00892 768493007864 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493007865 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493007866 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768493007867 dimerization interface [polypeptide binding]; other site 768493007868 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 768493007869 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 768493007870 active site 768493007871 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 768493007872 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 768493007873 Flavin binding site [chemical binding]; other site 768493007874 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 768493007875 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 768493007876 active site 768493007877 non-prolyl cis peptide bond; other site 768493007878 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 768493007879 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 768493007880 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 768493007881 Walker A/P-loop; other site 768493007882 ATP binding site [chemical binding]; other site 768493007883 Q-loop/lid; other site 768493007884 ABC transporter signature motif; other site 768493007885 Walker B; other site 768493007886 D-loop; other site 768493007887 H-loop/switch region; other site 768493007888 NIL domain; Region: NIL; cl09633 768493007889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493007890 dimer interface [polypeptide binding]; other site 768493007891 conserved gate region; other site 768493007892 ABC-ATPase subunit interface; other site 768493007893 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 768493007894 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768493007895 substrate binding pocket [chemical binding]; other site 768493007896 membrane-bound complex binding site; other site 768493007897 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 768493007898 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 768493007899 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768493007900 catalytic residue [active] 768493007901 serine O-acetyltransferase; Region: cysE; TIGR01172 768493007902 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 768493007903 trimer interface [polypeptide binding]; other site 768493007904 active site 768493007905 substrate binding site [chemical binding]; other site 768493007906 CoA binding site [chemical binding]; other site 768493007907 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 768493007908 active site residue [active] 768493007909 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 768493007910 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 768493007911 putative ligand binding site [chemical binding]; other site 768493007912 NAD binding site [chemical binding]; other site 768493007913 catalytic site [active] 768493007914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493007915 D-galactonate transporter; Region: 2A0114; TIGR00893 768493007916 putative substrate translocation pore; other site 768493007917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493007918 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 768493007919 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768493007920 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768493007921 putative active site [active] 768493007922 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 768493007923 beta-galactosidase; Region: BGL; TIGR03356 768493007924 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 768493007925 heterodimer interface [polypeptide binding]; other site 768493007926 multimer interface [polypeptide binding]; other site 768493007927 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 768493007928 active site 768493007929 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 768493007930 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 768493007931 heterodimer interface [polypeptide binding]; other site 768493007932 active site 768493007933 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 768493007934 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493007935 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768493007936 dimerization interface [polypeptide binding]; other site 768493007937 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 768493007938 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 768493007939 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 768493007940 tetramer interface [polypeptide binding]; other site 768493007941 active site 768493007942 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 768493007943 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768493007944 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 768493007945 benzoate transport; Region: 2A0115; TIGR00895 768493007946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493007947 putative substrate translocation pore; other site 768493007948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493007949 benzoate transport; Region: 2A0115; TIGR00895 768493007950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493007951 putative substrate translocation pore; other site 768493007952 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493007953 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 768493007954 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 768493007955 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 768493007956 shikimate binding site; other site 768493007957 NAD(P) binding site [chemical binding]; other site 768493007958 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 768493007959 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 768493007960 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 768493007961 dimer interface [polypeptide binding]; other site 768493007962 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 768493007963 active site 768493007964 Fe binding site [ion binding]; other site 768493007965 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 768493007966 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 768493007967 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768493007968 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 768493007969 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768493007970 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 768493007971 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 768493007972 Bacterial transcriptional regulator; Region: IclR; pfam01614 768493007973 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 768493007974 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 768493007975 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768493007976 catalytic residue [active] 768493007977 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 768493007978 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 768493007979 dimer interface [polypeptide binding]; other site 768493007980 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 768493007981 MASE1; Region: MASE1; cl17823 768493007982 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768493007983 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768493007984 metal binding site [ion binding]; metal-binding site 768493007985 active site 768493007986 I-site; other site 768493007987 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768493007988 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493007989 Coenzyme A binding pocket [chemical binding]; other site 768493007990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493007991 dimer interface [polypeptide binding]; other site 768493007992 conserved gate region; other site 768493007993 ABC-ATPase subunit interface; other site 768493007994 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 768493007995 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 768493007996 Walker A/P-loop; other site 768493007997 ATP binding site [chemical binding]; other site 768493007998 Q-loop/lid; other site 768493007999 ABC transporter signature motif; other site 768493008000 Walker B; other site 768493008001 D-loop; other site 768493008002 H-loop/switch region; other site 768493008003 NIL domain; Region: NIL; pfam09383 768493008004 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 768493008005 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 768493008006 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 768493008007 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 768493008008 putative N- and C-terminal domain interface [polypeptide binding]; other site 768493008009 putative active site [active] 768493008010 MgATP binding site [chemical binding]; other site 768493008011 catalytic site [active] 768493008012 metal binding site [ion binding]; metal-binding site 768493008013 putative xylulose binding site [chemical binding]; other site 768493008014 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 768493008015 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 768493008016 putative ligand binding site [chemical binding]; other site 768493008017 putative NAD binding site [chemical binding]; other site 768493008018 catalytic site [active] 768493008019 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 768493008020 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768493008021 substrate binding site [chemical binding]; other site 768493008022 ATP binding site [chemical binding]; other site 768493008023 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768493008024 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768493008025 TM-ABC transporter signature motif; other site 768493008026 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768493008027 TM-ABC transporter signature motif; other site 768493008028 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 768493008029 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768493008030 Walker A/P-loop; other site 768493008031 ATP binding site [chemical binding]; other site 768493008032 Q-loop/lid; other site 768493008033 ABC transporter signature motif; other site 768493008034 Walker B; other site 768493008035 D-loop; other site 768493008036 H-loop/switch region; other site 768493008037 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768493008038 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 768493008039 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 768493008040 putative ligand binding site [chemical binding]; other site 768493008041 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 768493008042 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 768493008043 Ca binding site [ion binding]; other site 768493008044 active site 768493008045 catalytic site [active] 768493008046 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 768493008047 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 768493008048 Walker A/P-loop; other site 768493008049 ATP binding site [chemical binding]; other site 768493008050 Q-loop/lid; other site 768493008051 ABC transporter signature motif; other site 768493008052 Walker B; other site 768493008053 D-loop; other site 768493008054 H-loop/switch region; other site 768493008055 TOBE domain; Region: TOBE_2; pfam08402 768493008056 alpha-galactosidase; Provisional; Region: PRK15076 768493008057 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 768493008058 NAD(P) binding site [chemical binding]; other site 768493008059 LDH/MDH dimer interface [polypeptide binding]; other site 768493008060 substrate binding site [chemical binding]; other site 768493008061 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 768493008062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493008063 dimer interface [polypeptide binding]; other site 768493008064 conserved gate region; other site 768493008065 putative PBP binding loops; other site 768493008066 ABC-ATPase subunit interface; other site 768493008067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493008068 dimer interface [polypeptide binding]; other site 768493008069 conserved gate region; other site 768493008070 putative PBP binding loops; other site 768493008071 ABC-ATPase subunit interface; other site 768493008072 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 768493008073 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 768493008074 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493008075 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493008076 LysR substrate binding domain; Region: LysR_substrate; pfam03466 768493008077 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768493008078 active site turn [active] 768493008079 phosphorylation site [posttranslational modification] 768493008080 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 768493008081 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 768493008082 Mechanosensitive ion channel; Region: MS_channel; pfam00924 768493008083 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 768493008084 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768493008085 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768493008086 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 768493008087 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768493008088 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768493008089 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493008090 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 768493008091 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 768493008092 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 768493008093 active site 768493008094 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 768493008095 Cation efflux family; Region: Cation_efflux; cl00316 768493008096 Cation efflux family; Region: Cation_efflux; cl00316 768493008097 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 768493008098 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 768493008099 Divalent cation transporter; Region: MgtE; pfam01769 768493008100 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 768493008101 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 768493008102 peptide binding site [polypeptide binding]; other site 768493008103 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768493008104 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 768493008105 active site 768493008106 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768493008107 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493008108 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768493008109 dimerization interface [polypeptide binding]; other site 768493008110 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 768493008111 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 768493008112 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 768493008113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493008114 dimer interface [polypeptide binding]; other site 768493008115 conserved gate region; other site 768493008116 putative PBP binding loops; other site 768493008117 ABC-ATPase subunit interface; other site 768493008118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493008119 dimer interface [polypeptide binding]; other site 768493008120 conserved gate region; other site 768493008121 putative PBP binding loops; other site 768493008122 ABC-ATPase subunit interface; other site 768493008123 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 768493008124 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 768493008125 Walker A/P-loop; other site 768493008126 ATP binding site [chemical binding]; other site 768493008127 Q-loop/lid; other site 768493008128 ABC transporter signature motif; other site 768493008129 Walker B; other site 768493008130 D-loop; other site 768493008131 H-loop/switch region; other site 768493008132 elongation factor G; Reviewed; Region: PRK00007 768493008133 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 768493008134 G1 box; other site 768493008135 putative GEF interaction site [polypeptide binding]; other site 768493008136 GTP/Mg2+ binding site [chemical binding]; other site 768493008137 Switch I region; other site 768493008138 G2 box; other site 768493008139 G3 box; other site 768493008140 Switch II region; other site 768493008141 G4 box; other site 768493008142 G5 box; other site 768493008143 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 768493008144 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 768493008145 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 768493008146 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768493008147 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 768493008148 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 768493008149 GIY-YIG motif/motif A; other site 768493008150 MarR family; Region: MarR_2; cl17246 768493008151 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768493008152 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493008153 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768493008154 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 768493008155 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 768493008156 tetramerization interface [polypeptide binding]; other site 768493008157 NAD(P) binding site [chemical binding]; other site 768493008158 catalytic residues [active] 768493008159 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 768493008160 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 768493008161 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 768493008162 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 768493008163 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768493008164 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768493008165 Cupin domain; Region: Cupin_2; pfam07883 768493008166 K+ potassium transporter; Region: K_trans; pfam02705 768493008167 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768493008168 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493008169 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 768493008170 dimerization interface [polypeptide binding]; other site 768493008171 substrate binding pocket [chemical binding]; other site 768493008172 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768493008173 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 768493008174 TM-ABC transporter signature motif; other site 768493008175 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 768493008176 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768493008177 TM-ABC transporter signature motif; other site 768493008178 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 768493008179 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 768493008180 Walker A/P-loop; other site 768493008181 ATP binding site [chemical binding]; other site 768493008182 Q-loop/lid; other site 768493008183 ABC transporter signature motif; other site 768493008184 Walker B; other site 768493008185 D-loop; other site 768493008186 H-loop/switch region; other site 768493008187 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 768493008188 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 768493008189 Walker A/P-loop; other site 768493008190 ATP binding site [chemical binding]; other site 768493008191 Q-loop/lid; other site 768493008192 ABC transporter signature motif; other site 768493008193 Walker B; other site 768493008194 D-loop; other site 768493008195 H-loop/switch region; other site 768493008196 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 768493008197 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 768493008198 dimerization interface [polypeptide binding]; other site 768493008199 ligand binding site [chemical binding]; other site 768493008200 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 768493008201 allantoate amidohydrolase; Reviewed; Region: PRK09290 768493008202 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 768493008203 active site 768493008204 metal binding site [ion binding]; metal-binding site 768493008205 dimer interface [polypeptide binding]; other site 768493008206 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768493008207 dimerization interface [polypeptide binding]; other site 768493008208 putative DNA binding site [nucleotide binding]; other site 768493008209 putative Zn2+ binding site [ion binding]; other site 768493008210 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 768493008211 putative hydrophobic ligand binding site [chemical binding]; other site 768493008212 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 768493008213 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 768493008214 Cl binding site [ion binding]; other site 768493008215 oligomer interface [polypeptide binding]; other site 768493008216 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 768493008217 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 768493008218 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 768493008219 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 768493008220 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 768493008221 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 768493008222 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 768493008223 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 768493008224 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768493008225 DNA-binding site [nucleotide binding]; DNA binding site 768493008226 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768493008227 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768493008228 catalytic residue [active] 768493008229 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 768493008230 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 768493008231 catalytic triad [active] 768493008232 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 768493008233 dimer interface [polypeptide binding]; other site 768493008234 pyridoxamine kinase; Validated; Region: PRK05756 768493008235 pyridoxal binding site [chemical binding]; other site 768493008236 ATP binding site [chemical binding]; other site 768493008237 Flagellar regulator YcgR; Region: YcgR; pfam07317 768493008238 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 768493008239 PilZ domain; Region: PilZ; pfam07238 768493008240 N-formylglutamate amidohydrolase; Region: FGase; cl01522 768493008241 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 768493008242 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 768493008243 putative acyl-acceptor binding pocket; other site 768493008244 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 768493008245 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 768493008246 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 768493008247 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 768493008248 DNA binding site [nucleotide binding] 768493008249 active site 768493008250 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 768493008251 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 768493008252 ligand binding site [chemical binding]; other site 768493008253 flexible hinge region; other site 768493008254 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 768493008255 putative switch regulator; other site 768493008256 non-specific DNA interactions [nucleotide binding]; other site 768493008257 DNA binding site [nucleotide binding] 768493008258 sequence specific DNA binding site [nucleotide binding]; other site 768493008259 putative cAMP binding site [chemical binding]; other site 768493008260 universal stress protein UspE; Provisional; Region: PRK11175 768493008261 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 768493008262 Ligand Binding Site [chemical binding]; other site 768493008263 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 768493008264 Ligand Binding Site [chemical binding]; other site 768493008265 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 768493008266 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 768493008267 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 768493008268 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 768493008269 ligand binding site [chemical binding]; other site 768493008270 homodimer interface [polypeptide binding]; other site 768493008271 NAD(P) binding site [chemical binding]; other site 768493008272 trimer interface B [polypeptide binding]; other site 768493008273 trimer interface A [polypeptide binding]; other site 768493008274 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 768493008275 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 768493008276 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 768493008277 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 768493008278 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 768493008279 dihydromonapterin reductase; Provisional; Region: PRK06483 768493008280 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768493008281 NAD(P) binding site [chemical binding]; other site 768493008282 active site 768493008283 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 768493008284 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493008285 active site 768493008286 phosphorylation site [posttranslational modification] 768493008287 intermolecular recognition site; other site 768493008288 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768493008289 DNA binding site [nucleotide binding] 768493008290 sensor protein RstB; Provisional; Region: PRK10604 768493008291 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768493008292 dimerization interface [polypeptide binding]; other site 768493008293 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768493008294 dimer interface [polypeptide binding]; other site 768493008295 phosphorylation site [posttranslational modification] 768493008296 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493008297 ATP binding site [chemical binding]; other site 768493008298 Mg2+ binding site [ion binding]; other site 768493008299 G-X-G motif; other site 768493008300 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 768493008301 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 768493008302 active site 768493008303 Zn binding site [ion binding]; other site 768493008304 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 768493008305 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 768493008306 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 768493008307 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 768493008308 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768493008309 ATP binding site [chemical binding]; other site 768493008310 putative Mg++ binding site [ion binding]; other site 768493008311 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768493008312 nucleotide binding region [chemical binding]; other site 768493008313 ATP-binding site [chemical binding]; other site 768493008314 Helicase associated domain (HA2); Region: HA2; pfam04408 768493008315 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 768493008316 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 768493008317 azoreductase; Reviewed; Region: PRK00170 768493008318 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768493008319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 768493008320 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 768493008321 hypothetical protein; Provisional; Region: PRK10695 768493008322 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 768493008323 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 768493008324 putative ligand binding site [chemical binding]; other site 768493008325 putative NAD binding site [chemical binding]; other site 768493008326 catalytic site [active] 768493008327 heat-inducible protein; Provisional; Region: PRK10449 768493008328 Domain of unknown function (DUF333); Region: DUF333; pfam03891 768493008329 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 768493008330 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 768493008331 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 768493008332 dimer interface [polypeptide binding]; other site 768493008333 PYR/PP interface [polypeptide binding]; other site 768493008334 TPP binding site [chemical binding]; other site 768493008335 substrate binding site [chemical binding]; other site 768493008336 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 768493008337 Domain of unknown function; Region: EKR; pfam10371 768493008338 4Fe-4S binding domain; Region: Fer4_6; pfam12837 768493008339 4Fe-4S binding domain; Region: Fer4; pfam00037 768493008340 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 768493008341 TPP-binding site [chemical binding]; other site 768493008342 dimer interface [polypeptide binding]; other site 768493008343 Alginate lyase; Region: Alginate_lyase; pfam05426 768493008344 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768493008345 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768493008346 non-specific DNA binding site [nucleotide binding]; other site 768493008347 salt bridge; other site 768493008348 sequence-specific DNA binding site [nucleotide binding]; other site 768493008349 Cupin domain; Region: Cupin_2; cl17218 768493008350 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 768493008351 B3/4 domain; Region: B3_4; pfam03483 768493008352 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 768493008353 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 768493008354 Ligand Binding Site [chemical binding]; other site 768493008355 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 768493008356 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768493008357 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 768493008358 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 768493008359 Cl binding site [ion binding]; other site 768493008360 oligomer interface [polypeptide binding]; other site 768493008361 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 768493008362 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 768493008363 peptide binding site [polypeptide binding]; other site 768493008364 Flagellar regulator YcgR; Region: YcgR; pfam07317 768493008365 murein peptide amidase A; Provisional; Region: PRK10602 768493008366 active site 768493008367 Zn binding site [ion binding]; other site 768493008368 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 768493008369 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 768493008370 active site 768493008371 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 768493008372 dimer interface [polypeptide binding]; other site 768493008373 catalytic triad [active] 768493008374 peroxidatic and resolving cysteines [active] 768493008375 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 768493008376 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 768493008377 putative aromatic amino acid binding site; other site 768493008378 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768493008379 putative active site [active] 768493008380 heme pocket [chemical binding]; other site 768493008381 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768493008382 Walker A motif; other site 768493008383 ATP binding site [chemical binding]; other site 768493008384 Walker B motif; other site 768493008385 arginine finger; other site 768493008386 hypothetical protein; Provisional; Region: PRK05415 768493008387 Domain of unknown function (DUF697); Region: DUF697; cl12064 768493008388 Predicted ATPase [General function prediction only]; Region: COG3106 768493008389 Phage shock protein PspD (Phageshock_PspD); Region: Phageshock_PspD; pfam09584 768493008390 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 768493008391 phage shock protein C; Region: phageshock_pspC; TIGR02978 768493008392 phage shock protein B; Provisional; Region: pspB; PRK09458 768493008393 phage shock protein PspA; Provisional; Region: PRK10698 768493008394 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 768493008395 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768493008396 Walker A motif; other site 768493008397 ATP binding site [chemical binding]; other site 768493008398 Walker B motif; other site 768493008399 arginine finger; other site 768493008400 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768493008401 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 768493008402 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 768493008403 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 768493008404 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 768493008405 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 768493008406 trimer interface [polypeptide binding]; other site 768493008407 active site 768493008408 putative GTP cyclohydrolase; Provisional; Region: PRK13674 768493008409 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 768493008410 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 768493008411 peptide binding site [polypeptide binding]; other site 768493008412 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 768493008413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493008414 dimer interface [polypeptide binding]; other site 768493008415 conserved gate region; other site 768493008416 putative PBP binding loops; other site 768493008417 ABC-ATPase subunit interface; other site 768493008418 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 768493008419 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 768493008420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493008421 dimer interface [polypeptide binding]; other site 768493008422 conserved gate region; other site 768493008423 putative PBP binding loops; other site 768493008424 ABC-ATPase subunit interface; other site 768493008425 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 768493008426 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768493008427 Walker A/P-loop; other site 768493008428 ATP binding site [chemical binding]; other site 768493008429 Q-loop/lid; other site 768493008430 ABC transporter signature motif; other site 768493008431 Walker B; other site 768493008432 D-loop; other site 768493008433 H-loop/switch region; other site 768493008434 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 768493008435 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 768493008436 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768493008437 Walker A/P-loop; other site 768493008438 ATP binding site [chemical binding]; other site 768493008439 Q-loop/lid; other site 768493008440 ABC transporter signature motif; other site 768493008441 Walker B; other site 768493008442 D-loop; other site 768493008443 H-loop/switch region; other site 768493008444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 768493008445 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 768493008446 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 768493008447 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493008448 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493008449 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768493008450 dimerization interface [polypeptide binding]; other site 768493008451 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 768493008452 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 768493008453 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 768493008454 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 768493008455 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 768493008456 putative molybdopterin cofactor binding site [chemical binding]; other site 768493008457 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 768493008458 putative molybdopterin cofactor binding site; other site 768493008459 exoribonuclease II; Provisional; Region: PRK05054 768493008460 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 768493008461 RNB domain; Region: RNB; pfam00773 768493008462 S1 RNA binding domain; Region: S1; pfam00575 768493008463 carbon starvation protein A; Provisional; Region: PRK15015 768493008464 Carbon starvation protein CstA; Region: CstA; pfam02554 768493008465 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 768493008466 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 768493008467 active site 768493008468 intersubunit interactions; other site 768493008469 catalytic residue [active] 768493008470 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 768493008471 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 768493008472 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 768493008473 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 768493008474 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 768493008475 intersubunit interface [polypeptide binding]; other site 768493008476 active site 768493008477 Zn2+ binding site [ion binding]; other site 768493008478 lipoprotein; Provisional; Region: PRK10540 768493008479 translation initiation factor Sui1; Validated; Region: PRK06824 768493008480 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 768493008481 putative rRNA binding site [nucleotide binding]; other site 768493008482 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 768493008483 active site 768493008484 dimer interface [polypeptide binding]; other site 768493008485 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 768493008486 tetratricopeptide repeat protein; Provisional; Region: PRK11788 768493008487 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 768493008488 TPR motif; other site 768493008489 binding surface 768493008490 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 768493008491 binding surface 768493008492 TPR motif; other site 768493008493 Predicted membrane protein [Function unknown]; Region: COG3771 768493008494 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 768493008495 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 768493008496 active site 768493008497 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 768493008498 dimerization interface [polypeptide binding]; other site 768493008499 active site 768493008500 aconitate hydratase; Validated; Region: PRK09277 768493008501 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 768493008502 substrate binding site [chemical binding]; other site 768493008503 ligand binding site [chemical binding]; other site 768493008504 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 768493008505 substrate binding site [chemical binding]; other site 768493008506 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 768493008507 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493008508 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 768493008509 substrate binding site [chemical binding]; other site 768493008510 putative dimerization interface [polypeptide binding]; other site 768493008511 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 768493008512 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 768493008513 active site 768493008514 interdomain interaction site; other site 768493008515 putative metal-binding site [ion binding]; other site 768493008516 nucleotide binding site [chemical binding]; other site 768493008517 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 768493008518 domain I; other site 768493008519 DNA binding groove [nucleotide binding] 768493008520 phosphate binding site [ion binding]; other site 768493008521 domain II; other site 768493008522 domain III; other site 768493008523 nucleotide binding site [chemical binding]; other site 768493008524 catalytic site [active] 768493008525 domain IV; other site 768493008526 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 768493008527 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 768493008528 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 768493008529 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 768493008530 hypothetical protein; Provisional; Region: PRK11037 768493008531 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 768493008532 putative inner membrane peptidase; Provisional; Region: PRK11778 768493008533 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 768493008534 tandem repeat interface [polypeptide binding]; other site 768493008535 oligomer interface [polypeptide binding]; other site 768493008536 active site residues [active] 768493008537 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 768493008538 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 768493008539 NADP binding site [chemical binding]; other site 768493008540 homodimer interface [polypeptide binding]; other site 768493008541 active site 768493008542 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 768493008543 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 768493008544 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 768493008545 homodimer interface [polypeptide binding]; other site 768493008546 Walker A motif; other site 768493008547 ATP binding site [chemical binding]; other site 768493008548 hydroxycobalamin binding site [chemical binding]; other site 768493008549 Walker B motif; other site 768493008550 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 768493008551 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768493008552 RNA binding surface [nucleotide binding]; other site 768493008553 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 768493008554 probable active site [active] 768493008555 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768493008556 hypothetical protein; Provisional; Region: PRK11630 768493008557 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 768493008558 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 768493008559 active site 768493008560 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 768493008561 anthranilate synthase component I; Provisional; Region: PRK13564 768493008562 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 768493008563 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 768493008564 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 768493008565 Glutamine amidotransferase class-I; Region: GATase; pfam00117 768493008566 glutamine binding [chemical binding]; other site 768493008567 catalytic triad [active] 768493008568 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 768493008569 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 768493008570 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 768493008571 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 768493008572 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 768493008573 active site 768493008574 ribulose/triose binding site [chemical binding]; other site 768493008575 phosphate binding site [ion binding]; other site 768493008576 substrate (anthranilate) binding pocket [chemical binding]; other site 768493008577 product (indole) binding pocket [chemical binding]; other site 768493008578 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 768493008579 active site 768493008580 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 768493008581 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 768493008582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493008583 catalytic residue [active] 768493008584 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 768493008585 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 768493008586 substrate binding site [chemical binding]; other site 768493008587 active site 768493008588 catalytic residues [active] 768493008589 heterodimer interface [polypeptide binding]; other site 768493008590 BON domain; Region: BON; pfam04972 768493008591 outer membrane protein W; Provisional; Region: PRK10959 768493008592 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 768493008593 hypothetical protein; Provisional; Region: PRK02868 768493008594 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 768493008595 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 768493008596 Sulfate transporter family; Region: Sulfate_transp; pfam00916 768493008597 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 768493008598 intracellular septation protein A; Reviewed; Region: PRK00259 768493008599 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 768493008600 transport protein TonB; Provisional; Region: PRK10819 768493008601 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 768493008602 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 768493008603 YciI-like protein; Reviewed; Region: PRK11370 768493008604 Head binding; Region: Head_binding; pfam09008 768493008605 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 768493008606 active site 768493008607 Mnt; Region: mnt; PHA01513 768493008608 Arc-like DNA binding domain; Region: Arc; pfam03869 768493008609 Regulatory protein Mnt; Region: Repressor_Mnt; pfam11423 768493008610 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 768493008611 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 768493008612 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768493008613 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768493008614 catalytic residue [active] 768493008615 Protein of unknown function (DUF2824); Region: DUF2824; cl10279 768493008616 Phage stabilisation protein; Region: Phage_stabilise; pfam11134 768493008617 P22 tail accessory factor; Region: P22_Tail-4; pfam11650 768493008618 coat protein; Region: PHA01511 768493008619 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 768493008620 Bacteriophage, scaffolding protein; Region: Phage-scaffold; pfam09306 768493008621 Terminase-like family; Region: Terminase_6; pfam03237 768493008622 Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565 768493008623 Terminase small subunit; Region: Terminase_2; pfam03592 768493008624 Protein of unknown function (DUF2560); Region: DUF2560; cl10280 768493008625 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 768493008626 Predicted chitinase [General function prediction only]; Region: COG3179 768493008627 catalytic residue [active] 768493008628 Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106 768493008629 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 768493008630 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 768493008631 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 768493008632 nucleotide binding site [chemical binding]; other site 768493008633 Virulence-associated protein E; Region: VirE; pfam05272 768493008634 putative Cro-like protein; Region: PHA00542 768493008635 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768493008636 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768493008637 sequence-specific DNA binding site [nucleotide binding]; other site 768493008638 salt bridge; other site 768493008639 Predicted transcriptional regulator [Transcription]; Region: COG2932 768493008640 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 768493008641 Catalytic site [active] 768493008642 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 768493008643 hypothetical protein; Provisional; Region: PRK09946 768493008644 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 768493008645 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 768493008646 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 768493008647 active site 768493008648 substrate binding site [chemical binding]; other site 768493008649 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 768493008650 active site 768493008651 DNA binding site [nucleotide binding] 768493008652 catalytic site [active] 768493008653 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 768493008654 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 768493008655 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 768493008656 ATP binding site [chemical binding]; other site 768493008657 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768493008658 nucleotide binding region [chemical binding]; other site 768493008659 ATP-binding site [chemical binding]; other site 768493008660 integrase; Provisional; Region: PRK09692 768493008661 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 768493008662 active site 768493008663 Int/Topo IB signature motif; other site 768493008664 KTSC domain; Region: KTSC; pfam13619 768493008665 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768493008666 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768493008667 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 768493008668 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493008669 putative substrate translocation pore; other site 768493008670 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 768493008671 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 768493008672 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 768493008673 putative active site [active] 768493008674 catalytic site [active] 768493008675 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 768493008676 putative active site [active] 768493008677 catalytic site [active] 768493008678 dsDNA-mimic protein; Reviewed; Region: PRK05094 768493008679 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 768493008680 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768493008681 Walker A/P-loop; other site 768493008682 ATP binding site [chemical binding]; other site 768493008683 Q-loop/lid; other site 768493008684 ABC transporter signature motif; other site 768493008685 Walker B; other site 768493008686 D-loop; other site 768493008687 H-loop/switch region; other site 768493008688 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 768493008689 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 768493008690 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768493008691 Walker A/P-loop; other site 768493008692 ATP binding site [chemical binding]; other site 768493008693 Q-loop/lid; other site 768493008694 ABC transporter signature motif; other site 768493008695 Walker B; other site 768493008696 D-loop; other site 768493008697 H-loop/switch region; other site 768493008698 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768493008699 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 768493008700 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 768493008701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493008702 dimer interface [polypeptide binding]; other site 768493008703 conserved gate region; other site 768493008704 ABC-ATPase subunit interface; other site 768493008705 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 768493008706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493008707 dimer interface [polypeptide binding]; other site 768493008708 conserved gate region; other site 768493008709 putative PBP binding loops; other site 768493008710 ABC-ATPase subunit interface; other site 768493008711 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 768493008712 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 768493008713 peptide binding site [polypeptide binding]; other site 768493008714 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 768493008715 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 768493008716 peptide binding site [polypeptide binding]; other site 768493008717 hypothetical protein; Provisional; Region: PRK11111 768493008718 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 768493008719 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 768493008720 putative catalytic cysteine [active] 768493008721 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 768493008722 putative active site [active] 768493008723 metal binding site [ion binding]; metal-binding site 768493008724 thymidine kinase; Provisional; Region: PRK04296 768493008725 Uncharacterized conserved protein (DUF2217); Region: DUF2217; pfam10265 768493008726 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 768493008727 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 768493008728 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768493008729 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 768493008730 putative NAD(P) binding site [chemical binding]; other site 768493008731 active site 768493008732 putative substrate binding site [chemical binding]; other site 768493008733 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 768493008734 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 768493008735 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 768493008736 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 768493008737 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 768493008738 active site 768493008739 tetramer interface; other site 768493008740 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493008741 active site 768493008742 response regulator of RpoS; Provisional; Region: PRK10693 768493008743 phosphorylation site [posttranslational modification] 768493008744 intermolecular recognition site; other site 768493008745 dimerization interface [polypeptide binding]; other site 768493008746 hypothetical protein; Provisional; Region: PRK10279 768493008747 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 768493008748 nucleophile elbow; other site 768493008749 SEC-C motif; Region: SEC-C; pfam02810 768493008750 hypothetical protein; Provisional; Region: PRK04233 768493008751 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 768493008752 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 768493008753 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 768493008754 putative active site [active] 768493008755 putative substrate binding site [chemical binding]; other site 768493008756 putative cosubstrate binding site; other site 768493008757 catalytic site [active] 768493008758 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 768493008759 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 768493008760 putative catalytic site [active] 768493008761 putative phosphate binding site [ion binding]; other site 768493008762 active site 768493008763 metal binding site A [ion binding]; metal-binding site 768493008764 DNA binding site [nucleotide binding] 768493008765 putative AP binding site [nucleotide binding]; other site 768493008766 putative metal binding site B [ion binding]; other site 768493008767 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 768493008768 active site 768493008769 8-oxo-dGMP binding site [chemical binding]; other site 768493008770 nudix motif; other site 768493008771 metal binding site [ion binding]; metal-binding site 768493008772 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 768493008773 DNA topoisomerase III; Provisional; Region: PRK07726 768493008774 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 768493008775 active site 768493008776 putative interdomain interaction site [polypeptide binding]; other site 768493008777 putative metal-binding site [ion binding]; other site 768493008778 putative nucleotide binding site [chemical binding]; other site 768493008779 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 768493008780 domain I; other site 768493008781 DNA binding groove [nucleotide binding] 768493008782 phosphate binding site [ion binding]; other site 768493008783 domain II; other site 768493008784 domain III; other site 768493008785 nucleotide binding site [chemical binding]; other site 768493008786 catalytic site [active] 768493008787 domain IV; other site 768493008788 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 768493008789 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 768493008790 active site residue [active] 768493008791 selenophosphate synthetase; Provisional; Region: PRK00943 768493008792 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 768493008793 dimerization interface [polypeptide binding]; other site 768493008794 putative ATP binding site [chemical binding]; other site 768493008795 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 768493008796 putative FMN binding site [chemical binding]; other site 768493008797 protease 4; Provisional; Region: PRK10949 768493008798 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 768493008799 tandem repeat interface [polypeptide binding]; other site 768493008800 oligomer interface [polypeptide binding]; other site 768493008801 active site residues [active] 768493008802 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 768493008803 tandem repeat interface [polypeptide binding]; other site 768493008804 oligomer interface [polypeptide binding]; other site 768493008805 active site residues [active] 768493008806 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 768493008807 active site 768493008808 homodimer interface [polypeptide binding]; other site 768493008809 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 768493008810 Isochorismatase family; Region: Isochorismatase; pfam00857 768493008811 catalytic triad [active] 768493008812 metal binding site [ion binding]; metal-binding site 768493008813 conserved cis-peptide bond; other site 768493008814 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 768493008815 Glyco_18 domain; Region: Glyco_18; smart00636 768493008816 active site 768493008817 Protein of unknown function (DUF1315); Region: DUF1315; pfam07023 768493008818 methionine sulfoxide reductase B; Provisional; Region: PRK00222 768493008819 SelR domain; Region: SelR; pfam01641 768493008820 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 768493008821 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 768493008822 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 768493008823 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 768493008824 active site 768493008825 phosphate binding residues; other site 768493008826 catalytic residues [active] 768493008827 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 768493008828 PrkA family serine protein kinase; Provisional; Region: PRK15455 768493008829 AAA ATPase domain; Region: AAA_16; pfam13191 768493008830 Walker A motif; other site 768493008831 ATP binding site [chemical binding]; other site 768493008832 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 768493008833 hypothetical protein; Provisional; Region: PRK05325 768493008834 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768493008835 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493008836 Coenzyme A binding pocket [chemical binding]; other site 768493008837 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 768493008838 intracellular protease, PfpI family; Region: PfpI; TIGR01382 768493008839 conserved cys residue [active] 768493008840 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 768493008841 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 768493008842 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 768493008843 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768493008844 N-terminal plug; other site 768493008845 ligand-binding site [chemical binding]; other site 768493008846 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768493008847 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 768493008848 Walker A/P-loop; other site 768493008849 ATP binding site [chemical binding]; other site 768493008850 Q-loop/lid; other site 768493008851 ABC transporter signature motif; other site 768493008852 Walker B; other site 768493008853 D-loop; other site 768493008854 H-loop/switch region; other site 768493008855 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 768493008856 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768493008857 Walker A/P-loop; other site 768493008858 ATP binding site [chemical binding]; other site 768493008859 Q-loop/lid; other site 768493008860 ABC transporter signature motif; other site 768493008861 Walker B; other site 768493008862 D-loop; other site 768493008863 H-loop/switch region; other site 768493008864 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768493008865 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 768493008866 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 768493008867 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 768493008868 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 768493008869 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 768493008870 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 768493008871 active site 768493008872 substrate binding site [chemical binding]; other site 768493008873 catalytic site [active] 768493008874 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493008875 putative substrate translocation pore; other site 768493008876 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768493008877 alanine racemase; Reviewed; Region: dadX; PRK03646 768493008878 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 768493008879 active site 768493008880 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768493008881 substrate binding site [chemical binding]; other site 768493008882 catalytic residues [active] 768493008883 dimer interface [polypeptide binding]; other site 768493008884 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 768493008885 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768493008886 hydroxyglutarate oxidase; Provisional; Region: PRK11728 768493008887 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 768493008888 active site 768493008889 catalytic triad [active] 768493008890 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 768493008891 Baseplate J-like protein; Region: Baseplate_J; cl01294 768493008892 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 768493008893 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 768493008894 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768493008895 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768493008896 catalytic residue [active] 768493008897 Protein of unknown function (DUF3277); Region: DUF3277; pfam11681 768493008898 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 768493008899 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 768493008900 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834 768493008901 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 768493008902 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 768493008903 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 768493008904 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 768493008905 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 768493008906 Terminase small subunit; Region: Terminase_2; pfam03592 768493008907 Predicted chitinase [General function prediction only]; Region: COG3179 768493008908 catalytic residue [active] 768493008909 Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106 768493008910 Poxvirus G5 protein; Region: Pox_G5; pfam04599 768493008911 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 768493008912 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 768493008913 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 768493008914 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 768493008915 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 768493008916 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 768493008917 cofactor binding site; other site 768493008918 DNA binding site [nucleotide binding] 768493008919 substrate interaction site [chemical binding]; other site 768493008920 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 768493008921 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 768493008922 replicative DNA helicase; Region: DnaB; TIGR00665 768493008923 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 768493008924 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 768493008925 Walker A motif; other site 768493008926 ATP binding site [chemical binding]; other site 768493008927 Walker B motif; other site 768493008928 DNA binding loops [nucleotide binding] 768493008929 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 768493008930 transcriptional repressor DicA; Reviewed; Region: PRK09706 768493008931 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768493008932 non-specific DNA binding site [nucleotide binding]; other site 768493008933 salt bridge; other site 768493008934 sequence-specific DNA binding site [nucleotide binding]; other site 768493008935 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 768493008936 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 768493008937 Excisionase-like protein; Region: Exc; pfam07825 768493008938 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 768493008939 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768493008940 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 768493008941 dimer interface [polypeptide binding]; other site 768493008942 active site 768493008943 Int/Topo IB signature motif; other site 768493008944 SpoVR family protein; Provisional; Region: PRK11767 768493008945 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 768493008946 fatty acid metabolism regulator; Provisional; Region: PRK04984 768493008947 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768493008948 DNA-binding site [nucleotide binding]; DNA binding site 768493008949 FadR C-terminal domain; Region: FadR_C; pfam07840 768493008950 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 768493008951 disulfide bond formation protein B; Provisional; Region: PRK01749 768493008952 hypothetical protein; Provisional; Region: PRK05170 768493008953 CsbD-like; Region: CsbD; cl17424 768493008954 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 768493008955 hypothetical protein; Provisional; Region: PRK10691 768493008956 Transglycosylase SLT domain; Region: SLT_2; pfam13406 768493008957 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768493008958 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768493008959 catalytic residue [active] 768493008960 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 768493008961 septum formation inhibitor; Reviewed; Region: minC; PRK03511 768493008962 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 768493008963 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 768493008964 cell division inhibitor MinD; Provisional; Region: PRK10818 768493008965 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 768493008966 Switch I; other site 768493008967 Switch II; other site 768493008968 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 768493008969 ribonuclease D; Provisional; Region: PRK10829 768493008970 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 768493008971 catalytic site [active] 768493008972 putative active site [active] 768493008973 putative substrate binding site [chemical binding]; other site 768493008974 Helicase and RNase D C-terminal; Region: HRDC; smart00341 768493008975 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 768493008976 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 768493008977 acyl-activating enzyme (AAE) consensus motif; other site 768493008978 putative AMP binding site [chemical binding]; other site 768493008979 putative active site [active] 768493008980 putative CoA binding site [chemical binding]; other site 768493008981 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 768493008982 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 768493008983 Glycoprotease family; Region: Peptidase_M22; pfam00814 768493008984 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 768493008985 DEAD/DEAH box helicase; Region: DEAD; pfam00270 768493008986 ATP binding site [chemical binding]; other site 768493008987 DEAD_2; Region: DEAD_2; pfam06733 768493008988 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 768493008989 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 768493008990 homotrimer interaction site [polypeptide binding]; other site 768493008991 putative active site [active] 768493008992 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 768493008993 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 768493008994 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 768493008995 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 768493008996 active site 768493008997 intersubunit interface [polypeptide binding]; other site 768493008998 catalytic residue [active] 768493008999 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 768493009000 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 768493009001 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 768493009002 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 768493009003 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768493009004 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768493009005 putative active site [active] 768493009006 pyruvate kinase; Provisional; Region: PRK05826 768493009007 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 768493009008 domain interfaces; other site 768493009009 active site 768493009010 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 768493009011 Leucine-rich repeats; other site 768493009012 Substrate binding site [chemical binding]; other site 768493009013 Leucine rich repeat; Region: LRR_8; pfam13855 768493009014 Leucine rich repeat; Region: LRR_8; pfam13855 768493009015 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 768493009016 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 768493009017 putative acyl-acceptor binding pocket; other site 768493009018 putative peptidase; Provisional; Region: PRK11649 768493009019 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 768493009020 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768493009021 Peptidase family M23; Region: Peptidase_M23; pfam01551 768493009022 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 768493009023 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 768493009024 metal binding site [ion binding]; metal-binding site 768493009025 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 768493009026 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 768493009027 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768493009028 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 768493009029 ABC-ATPase subunit interface; other site 768493009030 dimer interface [polypeptide binding]; other site 768493009031 putative PBP binding regions; other site 768493009032 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 768493009033 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768493009034 Walker A motif; other site 768493009035 ATP binding site [chemical binding]; other site 768493009036 Walker B motif; other site 768493009037 arginine finger; other site 768493009038 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 768493009039 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 768493009040 RuvA N terminal domain; Region: RuvA_N; pfam01330 768493009041 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 768493009042 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 768493009043 active site 768493009044 putative DNA-binding cleft [nucleotide binding]; other site 768493009045 dimer interface [polypeptide binding]; other site 768493009046 hypothetical protein; Validated; Region: PRK00110 768493009047 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 768493009048 nudix motif; other site 768493009049 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 768493009050 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 768493009051 dimer interface [polypeptide binding]; other site 768493009052 anticodon binding site; other site 768493009053 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 768493009054 homodimer interface [polypeptide binding]; other site 768493009055 motif 1; other site 768493009056 active site 768493009057 motif 2; other site 768493009058 GAD domain; Region: GAD; pfam02938 768493009059 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 768493009060 active site 768493009061 motif 3; other site 768493009062 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 768493009063 Isochorismatase family; Region: Isochorismatase; pfam00857 768493009064 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 768493009065 catalytic triad [active] 768493009066 conserved cis-peptide bond; other site 768493009067 hypothetical protein; Provisional; Region: PRK10302 768493009068 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 768493009069 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493009070 S-adenosylmethionine binding site [chemical binding]; other site 768493009071 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493009072 S-adenosylmethionine binding site [chemical binding]; other site 768493009073 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 768493009074 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 768493009075 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 768493009076 copper homeostasis protein CutC; Provisional; Region: PRK11572 768493009077 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 768493009078 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768493009079 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493009080 homodimer interface [polypeptide binding]; other site 768493009081 catalytic residue [active] 768493009082 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 768493009083 putative metal binding site [ion binding]; other site 768493009084 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 768493009085 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 768493009086 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 768493009087 active site 768493009088 HIGH motif; other site 768493009089 KMSK motif region; other site 768493009090 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 768493009091 tRNA binding surface [nucleotide binding]; other site 768493009092 anticodon binding site; other site 768493009093 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 768493009094 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 768493009095 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768493009096 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768493009097 hypothetical protein; Provisional; Region: PRK11239 768493009098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 768493009099 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 768493009100 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 768493009101 multidrug resistance protein MdtH; Provisional; Region: PRK11646 768493009102 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493009103 putative substrate translocation pore; other site 768493009104 glutaredoxin 2; Provisional; Region: PRK10387 768493009105 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 768493009106 C-terminal domain interface [polypeptide binding]; other site 768493009107 GSH binding site (G-site) [chemical binding]; other site 768493009108 catalytic residues [active] 768493009109 putative dimer interface [polypeptide binding]; other site 768493009110 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 768493009111 N-terminal domain interface [polypeptide binding]; other site 768493009112 ABC1 family; Region: ABC1; cl17513 768493009113 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 768493009114 lipoprotein; Provisional; Region: PRK10598 768493009115 hypothetical protein; Provisional; Region: PRK13680 768493009116 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 768493009117 YebG protein; Region: YebG; pfam07130 768493009118 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 768493009119 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 768493009120 ATP binding site [chemical binding]; other site 768493009121 Mg++ binding site [ion binding]; other site 768493009122 motif III; other site 768493009123 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768493009124 nucleotide binding region [chemical binding]; other site 768493009125 ATP-binding site [chemical binding]; other site 768493009126 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 768493009127 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 768493009128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768493009129 ATP-grasp domain; Region: ATP-grasp; pfam02222 768493009130 hypothetical protein; Provisional; Region: PRK05114 768493009131 putative glycosyl transferase; Provisional; Region: PRK10073 768493009132 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 768493009133 active site 768493009134 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 768493009135 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 768493009136 chorismate binding enzyme; Region: Chorismate_bind; cl10555 768493009137 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 768493009138 putative active site [active] 768493009139 putative CoA binding site [chemical binding]; other site 768493009140 nudix motif; other site 768493009141 metal binding site [ion binding]; metal-binding site 768493009142 L-serine deaminase; Provisional; Region: PRK15023 768493009143 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 768493009144 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 768493009145 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 768493009146 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768493009147 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 768493009148 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 768493009149 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 768493009150 Transporter associated domain; Region: CorC_HlyC; smart01091 768493009151 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 768493009152 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 768493009153 active pocket/dimerization site; other site 768493009154 active site 768493009155 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 768493009156 active site 768493009157 phosphorylation site [posttranslational modification] 768493009158 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 768493009159 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 768493009160 hypothetical protein; Provisional; Region: PRK02913 768493009161 Domain of unknown function DUF; Region: DUF204; pfam02659 768493009162 Domain of unknown function DUF; Region: DUF204; pfam02659 768493009163 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 768493009164 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493009165 putative substrate translocation pore; other site 768493009166 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768493009167 dimerization interface [polypeptide binding]; other site 768493009168 putative DNA binding site [nucleotide binding]; other site 768493009169 Transcriptional regulators [Transcription]; Region: MarR; COG1846 768493009170 putative Zn2+ binding site [ion binding]; other site 768493009171 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 768493009172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493009173 S-adenosylmethionine binding site [chemical binding]; other site 768493009174 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 768493009175 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 768493009176 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768493009177 DNA-binding site [nucleotide binding]; DNA binding site 768493009178 RNA-binding motif; other site 768493009179 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 768493009180 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 768493009181 aromatic amino acid transporter; Provisional; Region: PRK10238 768493009182 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 768493009183 Protein of unknown function (DUF2591); Region: DUF2591; pfam10765 768493009184 FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244 768493009185 dimer interface [polypeptide binding]; other site 768493009186 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768493009187 Mn binding site [ion binding]; other site 768493009188 K binding site [ion binding]; other site 768493009189 YebO-like protein; Region: YebO; pfam13974 768493009190 YobH-like protein; Region: YobH; pfam13996 768493009191 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 768493009192 YccJ-like protein; Region: YccJ; cl08091 768493009193 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 768493009194 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493009195 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 768493009196 Pirin; Region: Pirin; pfam02678 768493009197 Pirin-related protein [General function prediction only]; Region: COG1741 768493009198 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 768493009199 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 768493009200 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768493009201 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 768493009202 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 768493009203 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 768493009204 trimer interface [polypeptide binding]; other site 768493009205 eyelet of channel; other site 768493009206 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 768493009207 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 768493009208 putative active site [active] 768493009209 Zn binding site [ion binding]; other site 768493009210 succinylarginine dihydrolase; Provisional; Region: PRK13281 768493009211 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 768493009212 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 768493009213 NAD(P) binding site [chemical binding]; other site 768493009214 catalytic residues [active] 768493009215 arginine succinyltransferase; Provisional; Region: PRK10456 768493009216 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 768493009217 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 768493009218 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768493009219 inhibitor-cofactor binding pocket; inhibition site 768493009220 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493009221 catalytic residue [active] 768493009222 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 768493009223 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 768493009224 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 768493009225 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768493009226 Walker A/P-loop; other site 768493009227 ATP binding site [chemical binding]; other site 768493009228 Q-loop/lid; other site 768493009229 ABC transporter signature motif; other site 768493009230 Walker B; other site 768493009231 D-loop; other site 768493009232 H-loop/switch region; other site 768493009233 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 768493009234 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768493009235 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 768493009236 Walker A/P-loop; other site 768493009237 ATP binding site [chemical binding]; other site 768493009238 Q-loop/lid; other site 768493009239 ABC transporter signature motif; other site 768493009240 Walker B; other site 768493009241 D-loop; other site 768493009242 H-loop/switch region; other site 768493009243 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 768493009244 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 768493009245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493009246 dimer interface [polypeptide binding]; other site 768493009247 conserved gate region; other site 768493009248 putative PBP binding loops; other site 768493009249 ABC-ATPase subunit interface; other site 768493009250 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 768493009251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493009252 dimer interface [polypeptide binding]; other site 768493009253 conserved gate region; other site 768493009254 putative PBP binding loops; other site 768493009255 ABC-ATPase subunit interface; other site 768493009256 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 768493009257 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 768493009258 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768493009259 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768493009260 DNA-binding site [nucleotide binding]; DNA binding site 768493009261 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768493009262 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493009263 homodimer interface [polypeptide binding]; other site 768493009264 catalytic residue [active] 768493009265 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 768493009266 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 768493009267 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 768493009268 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 768493009269 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 768493009270 Fatty acid desaturase; Region: FA_desaturase; pfam00487 768493009271 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 768493009272 putative di-iron ligands [ion binding]; other site 768493009273 Fatty acid desaturase; Region: FA_desaturase; pfam00487 768493009274 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 768493009275 putative di-iron ligands [ion binding]; other site 768493009276 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 768493009277 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 768493009278 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 768493009279 active site 768493009280 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 768493009281 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 768493009282 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 768493009283 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 768493009284 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768493009285 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768493009286 NAD(P) binding site [chemical binding]; other site 768493009287 active site 768493009288 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 768493009289 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 768493009290 dimer interface [polypeptide binding]; other site 768493009291 active site 768493009292 CoA binding pocket [chemical binding]; other site 768493009293 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 768493009294 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 768493009295 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 768493009296 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 768493009297 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 768493009298 [4Fe-4S] binding site [ion binding]; other site 768493009299 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 768493009300 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 768493009301 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 768493009302 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 768493009303 molybdopterin cofactor binding site; other site 768493009304 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 768493009305 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 768493009306 active site 768493009307 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 768493009308 active site 768493009309 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 768493009310 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 768493009311 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 768493009312 active site 768493009313 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 768493009314 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 768493009315 putative ADP-binding pocket [chemical binding]; other site 768493009316 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768493009317 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 768493009318 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 768493009319 active site 768493009320 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 768493009321 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 768493009322 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 768493009323 tyrosine kinase; Provisional; Region: PRK11519 768493009324 Chain length determinant protein; Region: Wzz; pfam02706 768493009325 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 768493009326 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 768493009327 Nucleotide binding site [chemical binding]; other site 768493009328 DTAP/Switch II; other site 768493009329 Switch I; other site 768493009330 polysaccharide export protein Wza; Provisional; Region: PRK15078 768493009331 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 768493009332 SLBB domain; Region: SLBB; pfam10531 768493009333 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 768493009334 Mg++ binding site [ion binding]; other site 768493009335 putative catalytic motif [active] 768493009336 substrate binding site [chemical binding]; other site 768493009337 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768493009338 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 768493009339 NAD(P) binding site [chemical binding]; other site 768493009340 active site 768493009341 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 768493009342 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 768493009343 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 768493009344 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768493009345 dimerization interface [polypeptide binding]; other site 768493009346 Histidine kinase; Region: HisKA_3; pfam07730 768493009347 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493009348 ATP binding site [chemical binding]; other site 768493009349 Mg2+ binding site [ion binding]; other site 768493009350 G-X-G motif; other site 768493009351 transcriptional regulator NarL; Provisional; Region: PRK10651 768493009352 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493009353 active site 768493009354 phosphorylation site [posttranslational modification] 768493009355 intermolecular recognition site; other site 768493009356 dimerization interface [polypeptide binding]; other site 768493009357 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768493009358 DNA binding residues [nucleotide binding] 768493009359 dimerization interface [polypeptide binding]; other site 768493009360 putative invasin; Provisional; Region: PRK10177 768493009361 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 768493009362 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 768493009363 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 768493009364 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 768493009365 substrate binding site [chemical binding]; other site 768493009366 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 768493009367 active site 768493009368 SAM binding site [chemical binding]; other site 768493009369 homodimer interface [polypeptide binding]; other site 768493009370 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 768493009371 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 768493009372 [4Fe-4S] binding site [ion binding]; other site 768493009373 molybdopterin cofactor binding site; other site 768493009374 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 768493009375 molybdopterin cofactor binding site; other site 768493009376 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 768493009377 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 768493009378 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768493009379 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768493009380 nitrite reductase subunit NirD; Provisional; Region: PRK14989 768493009381 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768493009382 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 768493009383 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 768493009384 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 768493009385 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 768493009386 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 768493009387 Walker A/P-loop; other site 768493009388 ATP binding site [chemical binding]; other site 768493009389 Q-loop/lid; other site 768493009390 ABC transporter signature motif; other site 768493009391 Walker B; other site 768493009392 D-loop; other site 768493009393 H-loop/switch region; other site 768493009394 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 768493009395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493009396 dimer interface [polypeptide binding]; other site 768493009397 conserved gate region; other site 768493009398 putative PBP binding loops; other site 768493009399 ABC-ATPase subunit interface; other site 768493009400 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 768493009401 NMT1-like family; Region: NMT1_2; pfam13379 768493009402 Nitrate and nitrite sensing; Region: NIT; pfam08376 768493009403 ANTAR domain; Region: ANTAR; pfam03861 768493009404 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 768493009405 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 768493009406 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768493009407 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768493009408 Walker A/P-loop; other site 768493009409 ATP binding site [chemical binding]; other site 768493009410 Q-loop/lid; other site 768493009411 ABC transporter signature motif; other site 768493009412 Walker B; other site 768493009413 D-loop; other site 768493009414 H-loop/switch region; other site 768493009415 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768493009416 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 768493009417 Walker A/P-loop; other site 768493009418 ATP binding site [chemical binding]; other site 768493009419 Q-loop/lid; other site 768493009420 ABC transporter signature motif; other site 768493009421 Walker B; other site 768493009422 D-loop; other site 768493009423 H-loop/switch region; other site 768493009424 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 768493009425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493009426 dimer interface [polypeptide binding]; other site 768493009427 conserved gate region; other site 768493009428 putative PBP binding loops; other site 768493009429 ABC-ATPase subunit interface; other site 768493009430 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 768493009431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493009432 dimer interface [polypeptide binding]; other site 768493009433 conserved gate region; other site 768493009434 putative PBP binding loops; other site 768493009435 ABC-ATPase subunit interface; other site 768493009436 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 768493009437 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 768493009438 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 768493009439 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 768493009440 substrate binding site [chemical binding]; other site 768493009441 dimerization interface [polypeptide binding]; other site 768493009442 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 768493009443 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 768493009444 putative active site pocket [active] 768493009445 dimerization interface [polypeptide binding]; other site 768493009446 putative catalytic residue [active] 768493009447 cation transport regulator; Reviewed; Region: chaB; PRK09582 768493009448 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 768493009449 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 768493009450 FAD binding pocket [chemical binding]; other site 768493009451 FAD binding motif [chemical binding]; other site 768493009452 phosphate binding motif [ion binding]; other site 768493009453 NAD binding pocket [chemical binding]; other site 768493009454 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 768493009455 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 768493009456 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 768493009457 hypothetical protein; Provisional; Region: PRK10536 768493009458 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 768493009459 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 768493009460 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768493009461 N-terminal plug; other site 768493009462 ligand-binding site [chemical binding]; other site 768493009463 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 768493009464 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 768493009465 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 768493009466 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 768493009467 Imelysin; Region: Peptidase_M75; pfam09375 768493009468 Iron permease FTR1 family; Region: FTR1; cl00475 768493009469 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 768493009470 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 768493009471 Na binding site [ion binding]; other site 768493009472 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 768493009473 Predicted transcriptional regulator [Transcription]; Region: COG3905 768493009474 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 768493009475 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 768493009476 Glutamate binding site [chemical binding]; other site 768493009477 NAD binding site [chemical binding]; other site 768493009478 catalytic residues [active] 768493009479 YcfA-like protein; Region: YcfA; pfam07927 768493009480 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 768493009481 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 768493009482 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 768493009483 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 768493009484 Walker A/P-loop; other site 768493009485 ATP binding site [chemical binding]; other site 768493009486 Q-loop/lid; other site 768493009487 ABC transporter signature motif; other site 768493009488 Walker B; other site 768493009489 D-loop; other site 768493009490 H-loop/switch region; other site 768493009491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493009492 dimer interface [polypeptide binding]; other site 768493009493 conserved gate region; other site 768493009494 putative PBP binding loops; other site 768493009495 ABC-ATPase subunit interface; other site 768493009496 cystine transporter subunit; Provisional; Region: PRK11260 768493009497 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768493009498 substrate binding pocket [chemical binding]; other site 768493009499 membrane-bound complex binding site; other site 768493009500 hinge residues; other site 768493009501 D-cysteine desulfhydrase; Validated; Region: PRK03910 768493009502 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 768493009503 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493009504 catalytic residue [active] 768493009505 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 768493009506 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 768493009507 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768493009508 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 768493009509 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768493009510 DNA binding residues [nucleotide binding] 768493009511 flagellin; Validated; Region: PRK06819 768493009512 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 768493009513 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 768493009514 flagellar capping protein; Reviewed; Region: fliD; PRK08032 768493009515 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 768493009516 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 768493009517 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 768493009518 flagellar protein FliS; Validated; Region: fliS; PRK05685 768493009519 Flagellar protein FliT; Region: FliT; cl05125 768493009520 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768493009521 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493009522 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 768493009523 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 768493009524 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 768493009525 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 768493009526 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 768493009527 FliG C-terminal domain; Region: FliG_C; pfam01706 768493009528 flagellar assembly protein H; Validated; Region: fliH; PRK05687 768493009529 Flagellar assembly protein FliH; Region: FliH; pfam02108 768493009530 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 768493009531 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 768493009532 Walker A motif/ATP binding site; other site 768493009533 Walker B motif; other site 768493009534 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 768493009535 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 768493009536 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 768493009537 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 768493009538 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 768493009539 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 768493009540 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 768493009541 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 768493009542 Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190 768493009543 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 768493009544 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 768493009545 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 768493009546 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 768493009547 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 768493009548 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 768493009549 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 768493009550 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 768493009551 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 768493009552 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 768493009553 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 768493009554 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 768493009555 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 768493009556 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 768493009557 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 768493009558 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 768493009559 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 768493009560 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 768493009561 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 768493009562 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 768493009563 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 768493009564 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 768493009565 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 768493009566 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 768493009567 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 768493009568 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 768493009569 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 768493009570 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 768493009571 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 768493009572 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 768493009573 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 768493009574 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 768493009575 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 768493009576 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 768493009577 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 768493009578 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 768493009579 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 768493009580 FlgN protein; Region: FlgN; cl09176 768493009581 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 768493009582 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 768493009583 Predicted transcriptional regulator [Transcription]; Region: COG2944 768493009584 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768493009585 non-specific DNA binding site [nucleotide binding]; other site 768493009586 salt bridge; other site 768493009587 sequence-specific DNA binding site [nucleotide binding]; other site 768493009588 Flagellar protein FlhE; Region: FlhE; pfam06366 768493009589 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 768493009590 FHIPEP family; Region: FHIPEP; pfam00771 768493009591 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK12468 768493009592 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 768493009593 chemotaxis regulator CheZ; Provisional; Region: PRK11166 768493009594 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 768493009595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493009596 active site 768493009597 phosphorylation site [posttranslational modification] 768493009598 intermolecular recognition site; other site 768493009599 dimerization interface [polypeptide binding]; other site 768493009600 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 768493009601 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493009602 active site 768493009603 phosphorylation site [posttranslational modification] 768493009604 intermolecular recognition site; other site 768493009605 dimerization interface [polypeptide binding]; other site 768493009606 CheB methylesterase; Region: CheB_methylest; pfam01339 768493009607 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 768493009608 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 768493009609 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493009610 methyl-accepting protein IV; Provisional; Region: PRK09793 768493009611 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 768493009612 dimer interface [polypeptide binding]; other site 768493009613 ligand binding site [chemical binding]; other site 768493009614 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768493009615 dimerization interface [polypeptide binding]; other site 768493009616 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768493009617 dimer interface [polypeptide binding]; other site 768493009618 putative CheW interface [polypeptide binding]; other site 768493009619 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 768493009620 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 768493009621 dimer interface [polypeptide binding]; other site 768493009622 ligand binding site [chemical binding]; other site 768493009623 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768493009624 dimerization interface [polypeptide binding]; other site 768493009625 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768493009626 dimer interface [polypeptide binding]; other site 768493009627 putative CheW interface [polypeptide binding]; other site 768493009628 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 768493009629 putative CheA interaction surface; other site 768493009630 chemotaxis protein CheA; Provisional; Region: PRK10547 768493009631 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 768493009632 putative binding surface; other site 768493009633 active site 768493009634 CheY binding; Region: CheY-binding; pfam09078 768493009635 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 768493009636 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493009637 ATP binding site [chemical binding]; other site 768493009638 Mg2+ binding site [ion binding]; other site 768493009639 G-X-G motif; other site 768493009640 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 768493009641 flagellar motor protein MotB; Validated; Region: motB; PRK09041 768493009642 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 768493009643 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 768493009644 ligand binding site [chemical binding]; other site 768493009645 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 768493009646 flagellar motor protein MotA; Validated; Region: PRK09110 768493009647 transcriptional activator FlhC; Provisional; Region: PRK12722 768493009648 transcriptional activator FlhD; Provisional; Region: PRK02909 768493009649 Haemolysin expression modulating protein; Region: HHA; cl11501 768493009650 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 768493009651 Ligand Binding Site [chemical binding]; other site 768493009652 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 768493009653 Prostaglandin dehydrogenases; Region: PGDH; cd05288 768493009654 NAD(P) binding site [chemical binding]; other site 768493009655 substrate binding site [chemical binding]; other site 768493009656 dimer interface [polypeptide binding]; other site 768493009657 DNA gyrase inhibitor; Provisional; Region: PRK10016 768493009658 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 768493009659 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 768493009660 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 768493009661 active site 768493009662 DNA binding site [nucleotide binding] 768493009663 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 768493009664 Fungal chitosanase of glycosyl hydrolase group 75; Region: Glyco_hydro_75; pfam07335 768493009665 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 768493009666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493009667 putative substrate translocation pore; other site 768493009668 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 768493009669 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 768493009670 dimerization domain [polypeptide binding]; other site 768493009671 dimer interface [polypeptide binding]; other site 768493009672 catalytic residues [active] 768493009673 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 768493009674 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 768493009675 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 768493009676 Catalytic site [active] 768493009677 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 768493009678 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493009679 active site 768493009680 phosphorylation site [posttranslational modification] 768493009681 intermolecular recognition site; other site 768493009682 dimerization interface [polypeptide binding]; other site 768493009683 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768493009684 DNA binding residues [nucleotide binding] 768493009685 dimerization interface [polypeptide binding]; other site 768493009686 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 768493009687 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 768493009688 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 768493009689 Transmembrane secretion effector; Region: MFS_3; pfam05977 768493009690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493009691 putative substrate translocation pore; other site 768493009692 DoxX; Region: DoxX; pfam07681 768493009693 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 768493009694 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 768493009695 active site 768493009696 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 768493009697 Isochorismatase family; Region: Isochorismatase; pfam00857 768493009698 catalytic triad [active] 768493009699 dimer interface [polypeptide binding]; other site 768493009700 conserved cis-peptide bond; other site 768493009701 Protein of unknown function (DUF1427); Region: DUF1427; cl01771 768493009702 Response regulator receiver domain; Region: Response_reg; pfam00072 768493009703 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493009704 active site 768493009705 phosphorylation site [posttranslational modification] 768493009706 intermolecular recognition site; other site 768493009707 dimerization interface [polypeptide binding]; other site 768493009708 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 768493009709 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 768493009710 substrate binding site [chemical binding]; other site 768493009711 activation loop (A-loop); other site 768493009712 Predicted ATPase [General function prediction only]; Region: COG3899 768493009713 AAA ATPase domain; Region: AAA_16; pfam13191 768493009714 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 768493009715 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 768493009716 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768493009717 PAS fold; Region: PAS_3; pfam08447 768493009718 putative active site [active] 768493009719 heme pocket [chemical binding]; other site 768493009720 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768493009721 dimer interface [polypeptide binding]; other site 768493009722 phosphorylation site [posttranslational modification] 768493009723 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493009724 ATP binding site [chemical binding]; other site 768493009725 Mg2+ binding site [ion binding]; other site 768493009726 G-X-G motif; other site 768493009727 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 768493009728 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 768493009729 Bacterial transcriptional regulator; Region: IclR; pfam01614 768493009730 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 768493009731 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 768493009732 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 768493009733 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 768493009734 dimer interface [polypeptide binding]; other site 768493009735 active site 768493009736 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 768493009737 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 768493009738 ArsC family; Region: ArsC; pfam03960 768493009739 catalytic residues [active] 768493009740 arsenical pump membrane protein; Provisional; Region: PRK15445 768493009741 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 768493009742 transmembrane helices; other site 768493009743 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768493009744 dimerization interface [polypeptide binding]; other site 768493009745 putative DNA binding site [nucleotide binding]; other site 768493009746 putative Zn2+ binding site [ion binding]; other site 768493009747 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 768493009748 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 768493009749 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493009750 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493009751 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768493009752 putative effector binding pocket; other site 768493009753 dimerization interface [polypeptide binding]; other site 768493009754 Protein of unknown function, DUF606; Region: DUF606; pfam04657 768493009755 Protein of unknown function, DUF606; Region: DUF606; pfam04657 768493009756 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 768493009757 magnesium-transporting ATPase; Provisional; Region: PRK15122 768493009758 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 768493009759 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768493009760 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 768493009761 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768493009762 motif II; other site 768493009763 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 768493009764 magnesium transport protein MgtC; Provisional; Region: PRK15385 768493009765 MgtC family; Region: MgtC; pfam02308 768493009766 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 768493009767 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 768493009768 CoA-transferase family III; Region: CoA_transf_3; pfam02515 768493009769 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768493009770 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493009771 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 768493009772 dimerization interface [polypeptide binding]; other site 768493009773 substrate binding pocket [chemical binding]; other site 768493009774 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 768493009775 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768493009776 catalytic residue [active] 768493009777 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 768493009778 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768493009779 DNA binding residues [nucleotide binding] 768493009780 dimerization interface [polypeptide binding]; other site 768493009781 hypothetical protein; Provisional; Region: PRK10708 768493009782 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768493009783 DNA-binding site [nucleotide binding]; DNA binding site 768493009784 RNA-binding motif; other site 768493009785 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 768493009786 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 768493009787 NAD(P) binding site [chemical binding]; other site 768493009788 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 768493009789 putative catalytic site [active] 768493009790 putative metal binding site [ion binding]; other site 768493009791 putative phosphate binding site [ion binding]; other site 768493009792 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 768493009793 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768493009794 NAD(P) binding site [chemical binding]; other site 768493009795 active site 768493009796 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493009797 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493009798 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768493009799 putative effector binding pocket; other site 768493009800 dimerization interface [polypeptide binding]; other site 768493009801 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 768493009802 hypothetical protein; Provisional; Region: PRK10457 768493009803 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493009804 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493009805 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 768493009806 putative effector binding pocket; other site 768493009807 putative dimerization interface [polypeptide binding]; other site 768493009808 short chain dehydrogenase; Provisional; Region: PRK12744 768493009809 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 768493009810 NADP binding site [chemical binding]; other site 768493009811 homodimer interface [polypeptide binding]; other site 768493009812 active site 768493009813 substrate binding site [chemical binding]; other site 768493009814 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 768493009815 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768493009816 dimer interface [polypeptide binding]; other site 768493009817 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768493009818 metal binding site [ion binding]; metal-binding site 768493009819 active site 768493009820 I-site; other site 768493009821 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 768493009822 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 768493009823 substrate binding site [chemical binding]; other site 768493009824 dimer interface [polypeptide binding]; other site 768493009825 NADP binding site [chemical binding]; other site 768493009826 catalytic residues [active] 768493009827 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 768493009828 substrate binding site [chemical binding]; other site 768493009829 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 768493009830 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 768493009831 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 768493009832 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 768493009833 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 768493009834 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 768493009835 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 768493009836 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 768493009837 FAD binding pocket [chemical binding]; other site 768493009838 FAD binding motif [chemical binding]; other site 768493009839 phosphate binding motif [ion binding]; other site 768493009840 beta-alpha-beta structure motif; other site 768493009841 NAD(p) ribose binding residues [chemical binding]; other site 768493009842 NAD binding pocket [chemical binding]; other site 768493009843 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 768493009844 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768493009845 catalytic loop [active] 768493009846 iron binding site [ion binding]; other site 768493009847 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 768493009848 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768493009849 substrate binding site [chemical binding]; other site 768493009850 oxyanion hole (OAH) forming residues; other site 768493009851 trimer interface [polypeptide binding]; other site 768493009852 enoyl-CoA hydratase; Provisional; Region: PRK08140 768493009853 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768493009854 substrate binding site [chemical binding]; other site 768493009855 oxyanion hole (OAH) forming residues; other site 768493009856 trimer interface [polypeptide binding]; other site 768493009857 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 768493009858 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 768493009859 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768493009860 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768493009861 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 768493009862 CoenzymeA binding site [chemical binding]; other site 768493009863 subunit interaction site [polypeptide binding]; other site 768493009864 PHB binding site; other site 768493009865 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 768493009866 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 768493009867 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 768493009868 active site 768493009869 AMP binding site [chemical binding]; other site 768493009870 homodimer interface [polypeptide binding]; other site 768493009871 acyl-activating enzyme (AAE) consensus motif; other site 768493009872 CoA binding site [chemical binding]; other site 768493009873 PaaX-like protein; Region: PaaX; pfam07848 768493009874 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 768493009875 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 768493009876 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 768493009877 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 768493009878 putative trimer interface [polypeptide binding]; other site 768493009879 putative metal binding site [ion binding]; other site 768493009880 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768493009881 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768493009882 DNA-binding site [nucleotide binding]; DNA binding site 768493009883 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768493009884 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493009885 homodimer interface [polypeptide binding]; other site 768493009886 catalytic residue [active] 768493009887 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 768493009888 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 768493009889 conserved cys residue [active] 768493009890 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493009891 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 768493009892 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 768493009893 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 768493009894 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 768493009895 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768493009896 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493009897 homodimer interface [polypeptide binding]; other site 768493009898 catalytic residue [active] 768493009899 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 768493009900 homotrimer interaction site [polypeptide binding]; other site 768493009901 putative active site [active] 768493009902 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768493009903 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 768493009904 LysR family transcriptional regulator; Provisional; Region: PRK14997 768493009905 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493009906 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 768493009907 putative effector binding pocket; other site 768493009908 putative dimerization interface [polypeptide binding]; other site 768493009909 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 768493009910 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 768493009911 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 768493009912 putative N-terminal domain interface [polypeptide binding]; other site 768493009913 putative dimer interface [polypeptide binding]; other site 768493009914 putative substrate binding pocket (H-site) [chemical binding]; other site 768493009915 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 768493009916 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 768493009917 Glycogen synthesis protein; Region: GlgS; cl11663 768493009918 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 768493009919 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 768493009920 tetramerization interface [polypeptide binding]; other site 768493009921 NAD(P) binding site [chemical binding]; other site 768493009922 catalytic residues [active] 768493009923 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 768493009924 dimer interface [polypeptide binding]; other site 768493009925 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768493009926 ligand binding site [chemical binding]; other site 768493009927 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 768493009928 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493009929 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493009930 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 768493009931 putative effector binding pocket; other site 768493009932 putative dimerization interface [polypeptide binding]; other site 768493009933 Condensation domain; Region: Condensation; pfam00668 768493009934 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 768493009935 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 768493009936 acyl-activating enzyme (AAE) consensus motif; other site 768493009937 AMP binding site [chemical binding]; other site 768493009938 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768493009939 Condensation domain; Region: Condensation; pfam00668 768493009940 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 768493009941 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 768493009942 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 768493009943 acyl-activating enzyme (AAE) consensus motif; other site 768493009944 AMP binding site [chemical binding]; other site 768493009945 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768493009946 Condensation domain; Region: Condensation; pfam00668 768493009947 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 768493009948 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 768493009949 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 768493009950 acyl-activating enzyme (AAE) consensus motif; other site 768493009951 AMP binding site [chemical binding]; other site 768493009952 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768493009953 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 768493009954 Uncharacterized membrane protein [Function unknown]; Region: COG5427; cl02250 768493009955 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 768493009956 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 768493009957 Trp docking motif [polypeptide binding]; other site 768493009958 putative active site [active] 768493009959 galactoside permease; Reviewed; Region: lacY; PRK09528 768493009960 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493009961 putative substrate translocation pore; other site 768493009962 alpha-galactosidase; Provisional; Region: PRK15076 768493009963 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 768493009964 NAD binding site [chemical binding]; other site 768493009965 sugar binding site [chemical binding]; other site 768493009966 divalent metal binding site [ion binding]; other site 768493009967 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 768493009968 dimer interface [polypeptide binding]; other site 768493009969 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768493009970 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768493009971 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493009972 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493009973 MATE family multidrug exporter; Provisional; Region: PRK10189 768493009974 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 768493009975 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 768493009976 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 768493009977 ligand binding site [chemical binding]; other site 768493009978 flexible hinge region; other site 768493009979 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 768493009980 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 768493009981 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 768493009982 ligand binding site [chemical binding]; other site 768493009983 flexible hinge region; other site 768493009984 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 768493009985 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 768493009986 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 768493009987 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 768493009988 putative NAD(P) binding site [chemical binding]; other site 768493009989 short chain dehydrogenase; Provisional; Region: PRK06179 768493009990 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 768493009991 NADP binding site [chemical binding]; other site 768493009992 active site 768493009993 steroid binding site; other site 768493009994 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 768493009995 classical (c) SDRs; Region: SDR_c; cd05233 768493009996 NAD(P) binding site [chemical binding]; other site 768493009997 active site 768493009998 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 768493009999 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 768493010000 FMN binding site [chemical binding]; other site 768493010001 active site 768493010002 substrate binding site [chemical binding]; other site 768493010003 catalytic residue [active] 768493010004 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768493010005 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768493010006 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768493010007 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768493010008 metal binding site [ion binding]; metal-binding site 768493010009 active site 768493010010 I-site; other site 768493010011 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 768493010012 active site 768493010013 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 768493010014 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 768493010015 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 768493010016 Uncharacterized conserved protein [Function unknown]; Region: COG5361 768493010017 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 768493010018 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 768493010019 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 768493010020 putative NAD(P) binding site [chemical binding]; other site 768493010021 catalytic Zn binding site [ion binding]; other site 768493010022 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 768493010023 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 768493010024 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768493010025 Walker A motif; other site 768493010026 ATP binding site [chemical binding]; other site 768493010027 Walker B motif; other site 768493010028 arginine finger; other site 768493010029 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 768493010030 DNA-binding interface [nucleotide binding]; DNA binding site 768493010031 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768493010032 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768493010033 DNA binding site [nucleotide binding] 768493010034 domain linker motif; other site 768493010035 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 768493010036 putative dimerization interface [polypeptide binding]; other site 768493010037 putative ligand binding site [chemical binding]; other site 768493010038 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 768493010039 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 768493010040 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 768493010041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493010042 dimer interface [polypeptide binding]; other site 768493010043 conserved gate region; other site 768493010044 putative PBP binding loops; other site 768493010045 ABC-ATPase subunit interface; other site 768493010046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493010047 dimer interface [polypeptide binding]; other site 768493010048 conserved gate region; other site 768493010049 putative PBP binding loops; other site 768493010050 ABC-ATPase subunit interface; other site 768493010051 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 768493010052 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768493010053 Walker A/P-loop; other site 768493010054 ATP binding site [chemical binding]; other site 768493010055 Q-loop/lid; other site 768493010056 ABC transporter signature motif; other site 768493010057 Walker B; other site 768493010058 D-loop; other site 768493010059 H-loop/switch region; other site 768493010060 TOBE domain; Region: TOBE_2; pfam08402 768493010061 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 768493010062 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 768493010063 active site 768493010064 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 768493010065 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 768493010066 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 768493010067 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 768493010068 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 768493010069 conserved cys residue [active] 768493010070 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493010071 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768493010072 short chain dehydrogenase; Provisional; Region: PRK06197 768493010073 NAD(P) binding site [chemical binding]; other site 768493010074 active site 768493010075 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 768493010076 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 768493010077 Putative transcription activator [Transcription]; Region: TenA; COG0819 768493010078 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 768493010079 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 768493010080 Walker A/P-loop; other site 768493010081 ATP binding site [chemical binding]; other site 768493010082 Q-loop/lid; other site 768493010083 ABC transporter signature motif; other site 768493010084 Walker B; other site 768493010085 D-loop; other site 768493010086 H-loop/switch region; other site 768493010087 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 768493010088 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493010089 dimer interface [polypeptide binding]; other site 768493010090 conserved gate region; other site 768493010091 putative PBP binding loops; other site 768493010092 ABC-ATPase subunit interface; other site 768493010093 NMT1/THI5 like; Region: NMT1; pfam09084 768493010094 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 768493010095 substrate binding pocket [chemical binding]; other site 768493010096 membrane-bound complex binding site; other site 768493010097 hinge residues; other site 768493010098 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 768493010099 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768493010100 substrate binding pocket [chemical binding]; other site 768493010101 membrane-bound complex binding site; other site 768493010102 hinge residues; other site 768493010103 phosphoglycerol transferase I; Provisional; Region: PRK03776 768493010104 AMP nucleosidase; Provisional; Region: PRK08292 768493010105 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 768493010106 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 768493010107 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 768493010108 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493010109 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 768493010110 putative dimerization interface [polypeptide binding]; other site 768493010111 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 768493010112 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768493010113 NAD(P) binding site [chemical binding]; other site 768493010114 active site 768493010115 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768493010116 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768493010117 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493010118 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 768493010119 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 768493010120 TMP-binding site; other site 768493010121 ATP-binding site [chemical binding]; other site 768493010122 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493010123 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493010124 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 768493010125 putative effector binding pocket; other site 768493010126 putative dimerization interface [polypeptide binding]; other site 768493010127 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768493010128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493010129 putative substrate translocation pore; other site 768493010130 Predicted transcriptional regulators [Transcription]; Region: COG1733 768493010131 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 768493010132 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 768493010133 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 768493010134 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768493010135 putative NAD(P) binding site [chemical binding]; other site 768493010136 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 768493010137 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 768493010138 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 768493010139 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 768493010140 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768493010141 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768493010142 catalytic residue [active] 768493010143 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 768493010144 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 768493010145 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 768493010146 active site residue [active] 768493010147 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 768493010148 active site residue [active] 768493010149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493010150 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768493010151 putative substrate translocation pore; other site 768493010152 Serine hydrolase; Region: Ser_hydrolase; pfam06821 768493010153 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768493010154 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768493010155 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768493010156 putative DNA binding site [nucleotide binding]; other site 768493010157 putative Zn2+ binding site [ion binding]; other site 768493010158 AsnC family; Region: AsnC_trans_reg; pfam01037 768493010159 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 768493010160 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 768493010161 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 768493010162 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 768493010163 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 768493010164 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 768493010165 methionine synthase; Provisional; Region: PRK01207 768493010166 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 768493010167 substrate binding site [chemical binding]; other site 768493010168 THF binding site; other site 768493010169 zinc-binding site [ion binding]; other site 768493010170 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 768493010171 substrate binding site [chemical binding]; other site 768493010172 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768493010173 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493010174 citrate-proton symporter; Provisional; Region: PRK15075 768493010175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493010176 putative substrate translocation pore; other site 768493010177 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 768493010178 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 768493010179 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493010180 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493010181 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 768493010182 putative dimerization interface [polypeptide binding]; other site 768493010183 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 768493010184 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 768493010185 intersubunit interface [polypeptide binding]; other site 768493010186 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493010187 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493010188 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 768493010189 putative effector binding pocket; other site 768493010190 putative dimerization interface [polypeptide binding]; other site 768493010191 Restriction endonuclease; Region: Mrr_cat; pfam04471 768493010192 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 768493010193 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768493010194 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768493010195 putative active site [active] 768493010196 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 768493010197 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768493010198 N-terminal plug; other site 768493010199 ligand-binding site [chemical binding]; other site 768493010200 galactoside permease; Reviewed; Region: lacY; PRK09528 768493010201 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493010202 putative substrate translocation pore; other site 768493010203 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 768493010204 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 768493010205 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 768493010206 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 768493010207 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 768493010208 lac repressor; Reviewed; Region: lacI; PRK09526 768493010209 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768493010210 DNA binding site [nucleotide binding] 768493010211 domain linker motif; other site 768493010212 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 768493010213 ligand binding site [chemical binding]; other site 768493010214 dimerization interface (open form) [polypeptide binding]; other site 768493010215 dimerization interface (closed form) [polypeptide binding]; other site 768493010216 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768493010217 HAMP domain; Region: HAMP; pfam00672 768493010218 dimerization interface [polypeptide binding]; other site 768493010219 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768493010220 dimer interface [polypeptide binding]; other site 768493010221 phosphorylation site [posttranslational modification] 768493010222 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493010223 ATP binding site [chemical binding]; other site 768493010224 Mg2+ binding site [ion binding]; other site 768493010225 G-X-G motif; other site 768493010226 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768493010227 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768493010228 DNA binding residues [nucleotide binding] 768493010229 dimerization interface [polypeptide binding]; other site 768493010230 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768493010231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493010232 active site 768493010233 phosphorylation site [posttranslational modification] 768493010234 intermolecular recognition site; other site 768493010235 dimerization interface [polypeptide binding]; other site 768493010236 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768493010237 DNA binding site [nucleotide binding] 768493010238 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 768493010239 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 768493010240 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493010241 Coenzyme A binding pocket [chemical binding]; other site 768493010242 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768493010243 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768493010244 sequence-specific DNA binding site [nucleotide binding]; other site 768493010245 salt bridge; other site 768493010246 Cupin domain; Region: Cupin_2; pfam07883 768493010247 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 768493010248 putative FMN binding site [chemical binding]; other site 768493010249 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768493010250 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493010251 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768493010252 dimerization interface [polypeptide binding]; other site 768493010253 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 768493010254 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768493010255 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 768493010256 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 768493010257 putative active site [active] 768493010258 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 768493010259 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 768493010260 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 768493010261 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 768493010262 active site 768493010263 dimer interface [polypeptide binding]; other site 768493010264 non-prolyl cis peptide bond; other site 768493010265 insertion regions; other site 768493010266 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 768493010267 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768493010268 Walker A motif; other site 768493010269 ATP binding site [chemical binding]; other site 768493010270 Walker B motif; other site 768493010271 arginine finger; other site 768493010272 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 768493010273 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 768493010274 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768493010275 substrate binding pocket [chemical binding]; other site 768493010276 membrane-bound complex binding site; other site 768493010277 hinge residues; other site 768493010278 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 768493010279 alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030 768493010280 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 768493010281 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 768493010282 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 768493010283 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 768493010284 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768493010285 Walker A/P-loop; other site 768493010286 ATP binding site [chemical binding]; other site 768493010287 Q-loop/lid; other site 768493010288 ABC transporter signature motif; other site 768493010289 Walker B; other site 768493010290 D-loop; other site 768493010291 H-loop/switch region; other site 768493010292 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768493010293 Walker A/P-loop; other site 768493010294 ATP binding site [chemical binding]; other site 768493010295 Q-loop/lid; other site 768493010296 ABC transporter signature motif; other site 768493010297 Walker B; other site 768493010298 D-loop; other site 768493010299 H-loop/switch region; other site 768493010300 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 768493010301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493010302 putative PBP binding loops; other site 768493010303 ABC-ATPase subunit interface; other site 768493010304 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 768493010305 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 768493010306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493010307 dimer interface [polypeptide binding]; other site 768493010308 conserved gate region; other site 768493010309 putative PBP binding loops; other site 768493010310 ABC-ATPase subunit interface; other site 768493010311 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 768493010312 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 768493010313 alanine-tRNA ligase; Region: PLN02961 768493010314 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 768493010315 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493010316 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493010317 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768493010318 putative effector binding pocket; other site 768493010319 dimerization interface [polypeptide binding]; other site 768493010320 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 768493010321 Predicted permeases [General function prediction only]; Region: RarD; COG2962 768493010322 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 768493010323 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 768493010324 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 768493010325 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 768493010326 catalytic core [active] 768493010327 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 768493010328 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 768493010329 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 768493010330 transmembrane helices; other site 768493010331 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 768493010332 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 768493010333 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 768493010334 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 768493010335 citrate lyase subunit gamma; Provisional; Region: PRK13253 768493010336 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 768493010337 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 768493010338 putative active site [active] 768493010339 (T/H)XGH motif; other site 768493010340 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 768493010341 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493010342 active site 768493010343 phosphorylation site [posttranslational modification] 768493010344 intermolecular recognition site; other site 768493010345 dimerization interface [polypeptide binding]; other site 768493010346 Transcriptional regulator; Region: CitT; pfam12431 768493010347 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 768493010348 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 768493010349 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824 768493010350 putative hydrophobic ligand binding site [chemical binding]; other site 768493010351 acetoin reductases; Region: 23BDH; TIGR02415 768493010352 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768493010353 NAD(P) binding site [chemical binding]; other site 768493010354 active site 768493010355 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 768493010356 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 768493010357 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768493010358 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768493010359 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768493010360 E3 interaction surface; other site 768493010361 lipoyl attachment site [posttranslational modification]; other site 768493010362 dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843 768493010363 e3 binding domain; Region: E3_binding; pfam02817 768493010364 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 768493010365 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 768493010366 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 768493010367 alpha subunit interface [polypeptide binding]; other site 768493010368 TPP binding site [chemical binding]; other site 768493010369 heterodimer interface [polypeptide binding]; other site 768493010370 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768493010371 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 768493010372 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 768493010373 tetramer interface [polypeptide binding]; other site 768493010374 TPP-binding site [chemical binding]; other site 768493010375 heterodimer interface [polypeptide binding]; other site 768493010376 phosphorylation loop region [posttranslational modification] 768493010377 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 768493010378 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 768493010379 Walker A motif; other site 768493010380 ATP binding site [chemical binding]; other site 768493010381 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768493010382 DNA binding residues [nucleotide binding] 768493010383 dimerization interface [polypeptide binding]; other site 768493010384 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 768493010385 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 768493010386 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 768493010387 dimer interface [polypeptide binding]; other site 768493010388 active site 768493010389 heme binding site [chemical binding]; other site 768493010390 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 768493010391 HipA N-terminal domain; Region: Couple_hipA; pfam13657 768493010392 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 768493010393 HipA-like N-terminal domain; Region: HipA_N; pfam07805 768493010394 HipA-like C-terminal domain; Region: HipA_C; pfam07804 768493010395 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768493010396 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768493010397 non-specific DNA binding site [nucleotide binding]; other site 768493010398 salt bridge; other site 768493010399 sequence-specific DNA binding site [nucleotide binding]; other site 768493010400 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 768493010401 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768493010402 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493010403 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 768493010404 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493010405 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493010406 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 768493010407 putative effector binding pocket; other site 768493010408 putative dimerization interface [polypeptide binding]; other site 768493010409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493010410 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768493010411 putative substrate translocation pore; other site 768493010412 putative arabinose transporter; Provisional; Region: PRK03545 768493010413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493010414 putative substrate translocation pore; other site 768493010415 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 768493010416 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 768493010417 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 768493010418 Walker A/P-loop; other site 768493010419 ATP binding site [chemical binding]; other site 768493010420 Q-loop/lid; other site 768493010421 ABC transporter signature motif; other site 768493010422 Walker B; other site 768493010423 D-loop; other site 768493010424 H-loop/switch region; other site 768493010425 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 768493010426 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 768493010427 Walker A/P-loop; other site 768493010428 ATP binding site [chemical binding]; other site 768493010429 Q-loop/lid; other site 768493010430 ABC transporter signature motif; other site 768493010431 Walker B; other site 768493010432 D-loop; other site 768493010433 H-loop/switch region; other site 768493010434 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 768493010435 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 768493010436 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 768493010437 TM-ABC transporter signature motif; other site 768493010438 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768493010439 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 768493010440 TM-ABC transporter signature motif; other site 768493010441 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 768493010442 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 768493010443 dimerization interface [polypeptide binding]; other site 768493010444 ligand binding site [chemical binding]; other site 768493010445 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493010446 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493010447 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 768493010448 putative effector binding pocket; other site 768493010449 putative dimerization interface [polypeptide binding]; other site 768493010450 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 768493010451 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768493010452 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493010453 putative substrate translocation pore; other site 768493010454 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493010455 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493010456 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768493010457 putative effector binding pocket; other site 768493010458 dimerization interface [polypeptide binding]; other site 768493010459 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 768493010460 active sites [active] 768493010461 tetramer interface [polypeptide binding]; other site 768493010462 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 768493010463 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 768493010464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493010465 dimer interface [polypeptide binding]; other site 768493010466 conserved gate region; other site 768493010467 ABC-ATPase subunit interface; other site 768493010468 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 768493010469 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768493010470 Walker A/P-loop; other site 768493010471 ATP binding site [chemical binding]; other site 768493010472 Q-loop/lid; other site 768493010473 ABC transporter signature motif; other site 768493010474 Walker B; other site 768493010475 D-loop; other site 768493010476 H-loop/switch region; other site 768493010477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493010478 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768493010479 putative substrate translocation pore; other site 768493010480 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 768493010481 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 768493010482 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768493010483 HlyD family secretion protein; Region: HlyD_3; pfam13437 768493010484 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768493010485 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768493010486 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 768493010487 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 768493010488 Predicted transcriptional regulators [Transcription]; Region: COG1733 768493010489 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 768493010490 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 768493010491 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 768493010492 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 768493010493 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493010494 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768493010495 dimerization interface [polypeptide binding]; other site 768493010496 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 768493010497 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 768493010498 metal binding site [ion binding]; metal-binding site 768493010499 putative dimer interface [polypeptide binding]; other site 768493010500 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 768493010501 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768493010502 substrate binding pocket [chemical binding]; other site 768493010503 membrane-bound complex binding site; other site 768493010504 hinge residues; other site 768493010505 hypothetical protein; Provisional; Region: PRK05423 768493010506 Predicted membrane protein [Function unknown]; Region: COG1289 768493010507 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 768493010508 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 768493010509 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 768493010510 amidase catalytic site [active] 768493010511 Zn binding residues [ion binding]; other site 768493010512 substrate binding site [chemical binding]; other site 768493010513 Predicted transcriptional regulator [Transcription]; Region: COG2932 768493010514 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 768493010515 Catalytic site [active] 768493010516 Male sterility protein; Region: NAD_binding_4; pfam07993 768493010517 NAD(P) binding site [chemical binding]; other site 768493010518 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 768493010519 active site 768493010520 DNA polymerase III, theta subunit; Region: DNA_pol3_theta; cl11635 768493010521 exonuclease I; Provisional; Region: sbcB; PRK11779 768493010522 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 768493010523 active site 768493010524 catalytic site [active] 768493010525 substrate binding site [chemical binding]; other site 768493010526 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 768493010527 amino acid transporter; Region: 2A0306; TIGR00909 768493010528 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 768493010529 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 768493010530 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 768493010531 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768493010532 non-specific DNA binding site [nucleotide binding]; other site 768493010533 salt bridge; other site 768493010534 sequence-specific DNA binding site [nucleotide binding]; other site 768493010535 Cupin domain; Region: Cupin_2; pfam07883 768493010536 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 768493010537 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 768493010538 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 768493010539 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768493010540 Walker A/P-loop; other site 768493010541 ATP binding site [chemical binding]; other site 768493010542 Q-loop/lid; other site 768493010543 ABC transporter signature motif; other site 768493010544 Walker B; other site 768493010545 D-loop; other site 768493010546 H-loop/switch region; other site 768493010547 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768493010548 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768493010549 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768493010550 TM-ABC transporter signature motif; other site 768493010551 putative outer membrane receptor; Provisional; Region: PRK13513 768493010552 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768493010553 N-terminal plug; other site 768493010554 ligand-binding site [chemical binding]; other site 768493010555 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 768493010556 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768493010557 Walker A/P-loop; other site 768493010558 ATP binding site [chemical binding]; other site 768493010559 Q-loop/lid; other site 768493010560 ABC transporter signature motif; other site 768493010561 Walker B; other site 768493010562 D-loop; other site 768493010563 H-loop/switch region; other site 768493010564 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 768493010565 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 768493010566 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768493010567 ABC-ATPase subunit interface; other site 768493010568 dimer interface [polypeptide binding]; other site 768493010569 putative PBP binding regions; other site 768493010570 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768493010571 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768493010572 metal binding site [ion binding]; metal-binding site 768493010573 active site 768493010574 I-site; other site 768493010575 lysine transporter; Provisional; Region: PRK10836 768493010576 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 768493010577 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493010578 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 768493010579 putative dimerization interface [polypeptide binding]; other site 768493010580 Predicted membrane protein [Function unknown]; Region: COG2855 768493010581 endonuclease IV; Provisional; Region: PRK01060 768493010582 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 768493010583 AP (apurinic/apyrimidinic) site pocket; other site 768493010584 DNA interaction; other site 768493010585 Metal-binding active site; metal-binding site 768493010586 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 768493010587 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 768493010588 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 768493010589 active site 768493010590 P-loop; other site 768493010591 phosphorylation site [posttranslational modification] 768493010592 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 768493010593 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 768493010594 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 768493010595 putative substrate binding site [chemical binding]; other site 768493010596 putative ATP binding site [chemical binding]; other site 768493010597 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 768493010598 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 768493010599 active site 768493010600 phosphorylation site [posttranslational modification] 768493010601 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 768493010602 dimerization domain swap beta strand [polypeptide binding]; other site 768493010603 regulatory protein interface [polypeptide binding]; other site 768493010604 active site 768493010605 regulatory phosphorylation site [posttranslational modification]; other site 768493010606 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_19; cd04678 768493010607 nudix motif; other site 768493010608 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 768493010609 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 768493010610 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 768493010611 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 768493010612 molybdopterin cofactor binding site [chemical binding]; other site 768493010613 substrate binding site [chemical binding]; other site 768493010614 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 768493010615 molybdopterin cofactor binding site; other site 768493010616 sugar efflux transporter B; Provisional; Region: PRK15011 768493010617 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493010618 putative substrate translocation pore; other site 768493010619 Flagellin N-methylase; Region: FliB; cl00497 768493010620 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 768493010621 aromatic amino acid transport protein; Region: araaP; TIGR00837 768493010622 elongation factor P; Provisional; Region: PRK04542 768493010623 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 768493010624 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 768493010625 RNA binding site [nucleotide binding]; other site 768493010626 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 768493010627 RNA binding site [nucleotide binding]; other site 768493010628 mannonate dehydratase; Provisional; Region: PRK03906 768493010629 mannonate dehydratase; Region: uxuA; TIGR00695 768493010630 D-mannonate oxidoreductase; Provisional; Region: PRK15037 768493010631 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 768493010632 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 768493010633 Fimbrial protein; Region: Fimbrial; cl01416 768493010634 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 768493010635 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 768493010636 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 768493010637 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 768493010638 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 768493010639 active site 768493010640 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 768493010641 NlpC/P60 family; Region: NLPC_P60; pfam00877 768493010642 phage resistance protein; Provisional; Region: PRK10551 768493010643 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 768493010644 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768493010645 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 768493010646 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 768493010647 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 768493010648 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493010649 dimer interface [polypeptide binding]; other site 768493010650 conserved gate region; other site 768493010651 putative PBP binding loops; other site 768493010652 ABC-ATPase subunit interface; other site 768493010653 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 768493010654 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 768493010655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493010656 dimer interface [polypeptide binding]; other site 768493010657 conserved gate region; other site 768493010658 putative PBP binding loops; other site 768493010659 ABC-ATPase subunit interface; other site 768493010660 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 768493010661 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768493010662 Walker A/P-loop; other site 768493010663 ATP binding site [chemical binding]; other site 768493010664 Q-loop/lid; other site 768493010665 ABC transporter signature motif; other site 768493010666 Walker B; other site 768493010667 D-loop; other site 768493010668 H-loop/switch region; other site 768493010669 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768493010670 Walker A/P-loop; other site 768493010671 ATP binding site [chemical binding]; other site 768493010672 Q-loop/lid; other site 768493010673 ABC transporter signature motif; other site 768493010674 Walker B; other site 768493010675 D-loop; other site 768493010676 H-loop/switch region; other site 768493010677 hypothetical protein; Provisional; Region: PRK11835 768493010678 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493010679 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 768493010680 putative substrate translocation pore; other site 768493010681 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 768493010682 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768493010683 RNA binding surface [nucleotide binding]; other site 768493010684 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 768493010685 active site 768493010686 uracil binding [chemical binding]; other site 768493010687 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 768493010688 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768493010689 ATP binding site [chemical binding]; other site 768493010690 putative Mg++ binding site [ion binding]; other site 768493010691 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768493010692 nucleotide binding region [chemical binding]; other site 768493010693 ATP-binding site [chemical binding]; other site 768493010694 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 768493010695 5S rRNA interface [nucleotide binding]; other site 768493010696 CTC domain interface [polypeptide binding]; other site 768493010697 L16 interface [polypeptide binding]; other site 768493010698 Nucleoid-associated protein [General function prediction only]; Region: COG3081 768493010699 nucleoid-associated protein NdpA; Validated; Region: PRK00378 768493010700 hypothetical protein; Provisional; Region: PRK13689 768493010701 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 768493010702 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 768493010703 Sulfatase; Region: Sulfatase; cl17466 768493010704 DinI-like family; Region: DinI; cl11630 768493010705 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 768493010706 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 768493010707 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 768493010708 active site 768493010709 oxyanion hole [active] 768493010710 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 768493010711 Phage-related protein, tail component [Function unknown]; Region: COG4733 768493010712 Putative phage tail protein; Region: Phage-tail_3; pfam13550 768493010713 Fibronectin type 3 domain; Region: FN3; smart00060 768493010714 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 768493010715 Fibronectin type III protein; Region: DUF3672; pfam12421 768493010716 Phage-related protein, tail component [Function unknown]; Region: COG4723 768493010717 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 768493010718 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 768493010719 MPN+ (JAMM) motif; other site 768493010720 Zinc-binding site [ion binding]; other site 768493010721 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 768493010722 NlpC/P60 family; Region: NLPC_P60; cl17555 768493010723 Phage-related protein [Function unknown]; Region: gp18; COG4672 768493010724 Phage minor tail protein; Region: Phage_min_tail; pfam05939 768493010725 Phage-related minor tail protein [Function unknown]; Region: COG5281 768493010726 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 768493010727 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 768493010728 Minor tail protein T; Region: Phage_tail_T; cl05636 768493010729 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; cl06106 768493010730 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 768493010731 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 768493010732 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 768493010733 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 768493010734 Uncharacterized conserved protein (DUF2190); Region: DUF2190; cl02289 768493010735 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 768493010736 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 768493010737 oligomer interface [polypeptide binding]; other site 768493010738 active site residues [active] 768493010739 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 768493010740 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 768493010741 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 768493010742 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 768493010743 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 768493010744 Protein of unknown function (DUF2560); Region: DUF2560; cl10280 768493010745 DNA polymerase III, theta subunit; Region: DNA_pol3_theta; pfam06440 768493010746 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 768493010747 Protein of unknown function (DUF754); Region: DUF754; pfam05449 768493010748 Antitermination protein; Region: Antiterm; pfam03589 768493010749 Antitermination protein; Region: Antiterm; pfam03589 768493010750 Protein of unknown function (DUF968); Region: DUF968; pfam06147 768493010751 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 768493010752 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 768493010753 cofactor binding site; other site 768493010754 DNA binding site [nucleotide binding] 768493010755 substrate interaction site [chemical binding]; other site 768493010756 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 768493010757 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 768493010758 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 768493010759 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 768493010760 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 768493010761 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 768493010762 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768493010763 non-specific DNA binding site [nucleotide binding]; other site 768493010764 salt bridge; other site 768493010765 sequence-specific DNA binding site [nucleotide binding]; other site 768493010766 tellurite resistance protein terB; Region: terB; cd07176 768493010767 putative metal binding site [ion binding]; other site 768493010768 Uncharacterized conserved protein (DUF2303); Region: DUF2303; pfam10065 768493010769 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 768493010770 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 768493010771 DNA-binding interface [nucleotide binding]; DNA binding site 768493010772 Protein of unknown function (DUF551); Region: DUF551; pfam04448 768493010773 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 768493010774 active site 768493010775 catalytic site [active] 768493010776 substrate binding site [chemical binding]; other site 768493010777 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 768493010778 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768493010779 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768493010780 active site 768493010781 DNA binding site [nucleotide binding] 768493010782 Int/Topo IB signature motif; other site 768493010783 Acyltransferase family; Region: Acyl_transf_3; pfam01757 768493010784 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 768493010785 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 768493010786 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 768493010787 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 768493010788 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 768493010789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 768493010790 SnoaL-like domain; Region: SnoaL_2; pfam12680 768493010791 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768493010792 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768493010793 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768493010794 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 768493010795 putative metal binding site [ion binding]; other site 768493010796 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 768493010797 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 768493010798 trimer interface [polypeptide binding]; other site 768493010799 eyelet of channel; other site 768493010800 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493010801 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768493010802 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 768493010803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493010804 ATP binding site [chemical binding]; other site 768493010805 Mg2+ binding site [ion binding]; other site 768493010806 G-X-G motif; other site 768493010807 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 768493010808 putative binding surface; other site 768493010809 active site 768493010810 transcriptional regulator RcsB; Provisional; Region: PRK10840 768493010811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493010812 active site 768493010813 phosphorylation site [posttranslational modification] 768493010814 intermolecular recognition site; other site 768493010815 dimerization interface [polypeptide binding]; other site 768493010816 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768493010817 DNA binding residues [nucleotide binding] 768493010818 dimerization interface [polypeptide binding]; other site 768493010819 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 768493010820 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768493010821 dimer interface [polypeptide binding]; other site 768493010822 phosphorylation site [posttranslational modification] 768493010823 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493010824 ATP binding site [chemical binding]; other site 768493010825 Mg2+ binding site [ion binding]; other site 768493010826 G-X-G motif; other site 768493010827 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 768493010828 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493010829 active site 768493010830 phosphorylation site [posttranslational modification] 768493010831 intermolecular recognition site; other site 768493010832 dimerization interface [polypeptide binding]; other site 768493010833 DNA gyrase subunit A; Validated; Region: PRK05560 768493010834 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 768493010835 CAP-like domain; other site 768493010836 active site 768493010837 primary dimer interface [polypeptide binding]; other site 768493010838 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768493010839 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768493010840 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768493010841 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768493010842 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768493010843 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768493010844 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 768493010845 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493010846 S-adenosylmethionine binding site [chemical binding]; other site 768493010847 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 768493010848 ATP cone domain; Region: ATP-cone; pfam03477 768493010849 Class I ribonucleotide reductase; Region: RNR_I; cd01679 768493010850 active site 768493010851 dimer interface [polypeptide binding]; other site 768493010852 catalytic residues [active] 768493010853 effector binding site; other site 768493010854 R2 peptide binding site; other site 768493010855 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 768493010856 dimer interface [polypeptide binding]; other site 768493010857 putative radical transfer pathway; other site 768493010858 diiron center [ion binding]; other site 768493010859 tyrosyl radical; other site 768493010860 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768493010861 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 768493010862 catalytic loop [active] 768493010863 iron binding site [ion binding]; other site 768493010864 Hok/gef family; Region: HOK_GEF; cl11494 768493010865 hypothetical protein; Provisional; Region: PRK03673 768493010866 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 768493010867 putative MPT binding site; other site 768493010868 tyrosine transporter TyrP; Provisional; Region: PRK15132 768493010869 aromatic amino acid transport protein; Region: araaP; TIGR00837 768493010870 YfaZ precursor; Region: YfaZ; pfam07437 768493010871 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 768493010872 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 768493010873 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 768493010874 tetramer interface [polypeptide binding]; other site 768493010875 heme binding pocket [chemical binding]; other site 768493010876 NADPH binding site [chemical binding]; other site 768493010877 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 768493010878 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 768493010879 acyl-activating enzyme (AAE) consensus motif; other site 768493010880 putative AMP binding site [chemical binding]; other site 768493010881 putative active site [active] 768493010882 putative CoA binding site [chemical binding]; other site 768493010883 O-succinylbenzoate synthase; Provisional; Region: PRK05105 768493010884 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 768493010885 active site 768493010886 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768493010887 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 768493010888 substrate binding site [chemical binding]; other site 768493010889 oxyanion hole (OAH) forming residues; other site 768493010890 trimer interface [polypeptide binding]; other site 768493010891 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 768493010892 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 768493010893 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 768493010894 dimer interface [polypeptide binding]; other site 768493010895 tetramer interface [polypeptide binding]; other site 768493010896 PYR/PP interface [polypeptide binding]; other site 768493010897 TPP binding site [chemical binding]; other site 768493010898 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 768493010899 TPP-binding site; other site 768493010900 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 768493010901 chorismate binding enzyme; Region: Chorismate_bind; cl10555 768493010902 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 768493010903 Putative glucoamylase; Region: Glycoamylase; pfam10091 768493010904 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 768493010905 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 768493010906 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 768493010907 hypothetical protein; Provisional; Region: PRK10404 768493010908 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 768493010909 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 768493010910 putative NAD(P) binding site [chemical binding]; other site 768493010911 catalytic Zn binding site [ion binding]; other site 768493010912 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 768493010913 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 768493010914 NADP binding site [chemical binding]; other site 768493010915 homodimer interface [polypeptide binding]; other site 768493010916 active site 768493010917 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 768493010918 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768493010919 DNA binding site [nucleotide binding] 768493010920 domain linker motif; other site 768493010921 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 768493010922 putative ligand binding site [chemical binding]; other site 768493010923 putative dimerization interface [polypeptide binding]; other site 768493010924 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 768493010925 Transmembrane secretion effector; Region: MFS_3; pfam05977 768493010926 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 768493010927 Cupin domain; Region: Cupin_2; cl17218 768493010928 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 768493010929 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768493010930 PYR/PP interface [polypeptide binding]; other site 768493010931 dimer interface [polypeptide binding]; other site 768493010932 TPP binding site [chemical binding]; other site 768493010933 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768493010934 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 768493010935 TPP-binding site [chemical binding]; other site 768493010936 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493010937 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493010938 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768493010939 dimerization interface [polypeptide binding]; other site 768493010940 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 768493010941 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 768493010942 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 768493010943 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 768493010944 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 768493010945 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 768493010946 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 768493010947 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 768493010948 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 768493010949 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 768493010950 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 768493010951 4Fe-4S binding domain; Region: Fer4; pfam00037 768493010952 4Fe-4S binding domain; Region: Fer4; pfam00037 768493010953 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 768493010954 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 768493010955 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768493010956 catalytic loop [active] 768493010957 iron binding site [ion binding]; other site 768493010958 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 768493010959 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 768493010960 [4Fe-4S] binding site [ion binding]; other site 768493010961 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 768493010962 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 768493010963 SLBB domain; Region: SLBB; pfam10531 768493010964 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 768493010965 NADH dehydrogenase subunit E; Validated; Region: PRK07539 768493010966 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 768493010967 putative dimer interface [polypeptide binding]; other site 768493010968 [2Fe-2S] cluster binding site [ion binding]; other site 768493010969 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 768493010970 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 768493010971 NADH dehydrogenase subunit D; Validated; Region: PRK06075 768493010972 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 768493010973 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 768493010974 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 768493010975 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493010976 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 768493010977 putative dimerization interface [polypeptide binding]; other site 768493010978 aminotransferase AlaT; Validated; Region: PRK09265 768493010979 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768493010980 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493010981 homodimer interface [polypeptide binding]; other site 768493010982 catalytic residue [active] 768493010983 5'-nucleotidase; Provisional; Region: PRK03826 768493010984 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 768493010985 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 768493010986 TrkA-C domain; Region: TrkA_C; pfam02080 768493010987 TrkA-C domain; Region: TrkA_C; pfam02080 768493010988 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 768493010989 putative phosphatase; Provisional; Region: PRK11587 768493010990 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768493010991 motif II; other site 768493010992 hypothetical protein; Validated; Region: PRK05445 768493010993 hypothetical protein; Provisional; Region: PRK01816 768493010994 propionate/acetate kinase; Provisional; Region: PRK12379 768493010995 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 768493010996 phosphate acetyltransferase; Reviewed; Region: PRK05632 768493010997 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 768493010998 DRTGG domain; Region: DRTGG; pfam07085 768493010999 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 768493011000 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 768493011001 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 768493011002 nudix motif; other site 768493011003 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 768493011004 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 768493011005 active site 768493011006 metal binding site [ion binding]; metal-binding site 768493011007 homotetramer interface [polypeptide binding]; other site 768493011008 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 768493011009 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 768493011010 C-terminal domain interface [polypeptide binding]; other site 768493011011 GSH binding site (G-site) [chemical binding]; other site 768493011012 dimer interface [polypeptide binding]; other site 768493011013 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 768493011014 N-terminal domain interface [polypeptide binding]; other site 768493011015 putative dimer interface [polypeptide binding]; other site 768493011016 active site 768493011017 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 768493011018 homooctamer interface [polypeptide binding]; other site 768493011019 active site 768493011020 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 768493011021 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 768493011022 putative NAD(P) binding site [chemical binding]; other site 768493011023 putative active site [active] 768493011024 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 768493011025 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 768493011026 Walker A/P-loop; other site 768493011027 ATP binding site [chemical binding]; other site 768493011028 Q-loop/lid; other site 768493011029 ABC transporter signature motif; other site 768493011030 Walker B; other site 768493011031 D-loop; other site 768493011032 H-loop/switch region; other site 768493011033 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768493011034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493011035 dimer interface [polypeptide binding]; other site 768493011036 conserved gate region; other site 768493011037 putative PBP binding loops; other site 768493011038 ABC-ATPase subunit interface; other site 768493011039 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768493011040 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493011041 dimer interface [polypeptide binding]; other site 768493011042 conserved gate region; other site 768493011043 putative PBP binding loops; other site 768493011044 ABC-ATPase subunit interface; other site 768493011045 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768493011046 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768493011047 substrate binding pocket [chemical binding]; other site 768493011048 membrane-bound complex binding site; other site 768493011049 hinge residues; other site 768493011050 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 768493011051 Flavoprotein; Region: Flavoprotein; pfam02441 768493011052 amidophosphoribosyltransferase; Provisional; Region: PRK09246 768493011053 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 768493011054 active site 768493011055 tetramer interface [polypeptide binding]; other site 768493011056 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768493011057 active site 768493011058 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 768493011059 colicin V production protein; Provisional; Region: PRK10845 768493011060 cell division protein DedD; Provisional; Region: PRK11633 768493011061 Sporulation related domain; Region: SPOR; pfam05036 768493011062 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 768493011063 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768493011064 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768493011065 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 768493011066 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 768493011067 hypothetical protein; Provisional; Region: PRK10847 768493011068 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 768493011069 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 768493011070 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 768493011071 dimerization interface 3.5A [polypeptide binding]; other site 768493011072 active site 768493011073 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 768493011074 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 768493011075 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 768493011076 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 768493011077 ligand binding site [chemical binding]; other site 768493011078 NAD binding site [chemical binding]; other site 768493011079 catalytic site [active] 768493011080 homodimer interface [polypeptide binding]; other site 768493011081 Cupin domain; Region: Cupin_2; cl17218 768493011082 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768493011083 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493011084 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493011085 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768493011086 EamA-like transporter family; Region: EamA; pfam00892 768493011087 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 768493011088 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768493011089 HAMP domain; Region: HAMP; pfam00672 768493011090 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768493011091 dimer interface [polypeptide binding]; other site 768493011092 phosphorylation site [posttranslational modification] 768493011093 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493011094 ATP binding site [chemical binding]; other site 768493011095 Mg2+ binding site [ion binding]; other site 768493011096 G-X-G motif; other site 768493011097 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 768493011098 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493011099 active site 768493011100 phosphorylation site [posttranslational modification] 768493011101 intermolecular recognition site; other site 768493011102 dimerization interface [polypeptide binding]; other site 768493011103 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768493011104 DNA binding site [nucleotide binding] 768493011105 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 768493011106 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 768493011107 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 768493011108 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 768493011109 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 768493011110 trimer interface [polypeptide binding]; other site 768493011111 active site 768493011112 CoA binding site [chemical binding]; other site 768493011113 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 768493011114 EamA-like transporter family; Region: EamA; pfam00892 768493011115 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768493011116 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768493011117 DNA-binding site [nucleotide binding]; DNA binding site 768493011118 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768493011119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493011120 homodimer interface [polypeptide binding]; other site 768493011121 catalytic residue [active] 768493011122 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 768493011123 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 768493011124 catalytic residues [active] 768493011125 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 768493011126 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 768493011127 catalytic residues [active] 768493011128 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 768493011129 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 768493011130 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 768493011131 DsbD alpha interface [polypeptide binding]; other site 768493011132 catalytic residues [active] 768493011133 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 768493011134 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 768493011135 active site residue [active] 768493011136 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768493011137 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768493011138 DNA-binding site [nucleotide binding]; DNA binding site 768493011139 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768493011140 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493011141 homodimer interface [polypeptide binding]; other site 768493011142 catalytic residue [active] 768493011143 putative transporter; Provisional; Region: PRK12382 768493011144 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493011145 putative substrate translocation pore; other site 768493011146 putative catalytic site [active] 768493011147 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 768493011148 putative metal binding site [ion binding]; other site 768493011149 putative phosphate binding site [ion binding]; other site 768493011150 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 768493011151 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 768493011152 metal binding site [ion binding]; metal-binding site 768493011153 dimer interface [polypeptide binding]; other site 768493011154 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 768493011155 transmembrane helices; other site 768493011156 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 768493011157 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 768493011158 ApbE family; Region: ApbE; pfam02424 768493011159 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 768493011160 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 768493011161 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 768493011162 dimer interface [polypeptide binding]; other site 768493011163 active site 768493011164 Uncharacterized conserved protein [Function unknown]; Region: COG4121 768493011165 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 768493011166 YfcL protein; Region: YfcL; pfam08891 768493011167 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 768493011168 hypothetical protein; Provisional; Region: PRK10621 768493011169 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 768493011170 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 768493011171 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 768493011172 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 768493011173 Tetramer interface [polypeptide binding]; other site 768493011174 active site 768493011175 FMN-binding site [chemical binding]; other site 768493011176 HemK family putative methylases; Region: hemK_fam; TIGR00536 768493011177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493011178 S-adenosylmethionine binding site [chemical binding]; other site 768493011179 hypothetical protein; Provisional; Region: PRK04946 768493011180 Smr domain; Region: Smr; pfam01713 768493011181 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768493011182 catalytic core [active] 768493011183 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 768493011184 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768493011185 substrate binding site [chemical binding]; other site 768493011186 oxyanion hole (OAH) forming residues; other site 768493011187 trimer interface [polypeptide binding]; other site 768493011188 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 768493011189 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768493011190 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768493011191 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 768493011192 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 768493011193 dimer interface [polypeptide binding]; other site 768493011194 active site 768493011195 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 768493011196 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 768493011197 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 768493011198 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 768493011199 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 768493011200 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768493011201 binding surface 768493011202 TPR motif; other site 768493011203 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 768493011204 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 768493011205 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 768493011206 catalytic residues [active] 768493011207 central insert; other site 768493011208 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 768493011209 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 768493011210 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 768493011211 heme exporter protein CcmC; Region: ccmC; TIGR01191 768493011212 heme exporter protein CcmB; Region: ccmB; TIGR01190 768493011213 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 768493011214 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 768493011215 Walker A/P-loop; other site 768493011216 ATP binding site [chemical binding]; other site 768493011217 Q-loop/lid; other site 768493011218 ABC transporter signature motif; other site 768493011219 Walker B; other site 768493011220 D-loop; other site 768493011221 H-loop/switch region; other site 768493011222 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 768493011223 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 768493011224 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493011225 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 768493011226 dimerization interface [polypeptide binding]; other site 768493011227 substrate binding pocket [chemical binding]; other site 768493011228 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768493011229 EamA-like transporter family; Region: EamA; pfam00892 768493011230 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 768493011231 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 768493011232 Transglycosylase SLT domain; Region: SLT_2; pfam13406 768493011233 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768493011234 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768493011235 catalytic residue [active] 768493011236 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 768493011237 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 768493011238 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 768493011239 aminotransferase; Validated; Region: PRK08175 768493011240 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768493011241 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493011242 homodimer interface [polypeptide binding]; other site 768493011243 catalytic residue [active] 768493011244 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 768493011245 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768493011246 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 768493011247 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 768493011248 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 768493011249 GAF domain; Region: GAF; pfam01590 768493011250 Histidine kinase; Region: His_kinase; pfam06580 768493011251 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493011252 ATP binding site [chemical binding]; other site 768493011253 Mg2+ binding site [ion binding]; other site 768493011254 G-X-G motif; other site 768493011255 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 768493011256 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493011257 active site 768493011258 phosphorylation site [posttranslational modification] 768493011259 intermolecular recognition site; other site 768493011260 dimerization interface [polypeptide binding]; other site 768493011261 LytTr DNA-binding domain; Region: LytTR; pfam04397 768493011262 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 768493011263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493011264 putative substrate translocation pore; other site 768493011265 glucokinase, proteobacterial type; Region: glk; TIGR00749 768493011266 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768493011267 nucleotide binding site [chemical binding]; other site 768493011268 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 768493011269 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 768493011270 Cl- selectivity filter; other site 768493011271 Cl- binding residues [ion binding]; other site 768493011272 pore gating glutamate residue; other site 768493011273 dimer interface [polypeptide binding]; other site 768493011274 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 768493011275 aspartate racemase; Region: asp_race; TIGR00035 768493011276 Predicted membrane protein [Function unknown]; Region: COG4125 768493011277 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 768493011278 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 768493011279 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493011280 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493011281 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768493011282 dimerization interface [polypeptide binding]; other site 768493011283 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 768493011284 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 768493011285 dimer interface [polypeptide binding]; other site 768493011286 PYR/PP interface [polypeptide binding]; other site 768493011287 TPP binding site [chemical binding]; other site 768493011288 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768493011289 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 768493011290 TPP-binding site [chemical binding]; other site 768493011291 dimer interface [polypeptide binding]; other site 768493011292 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768493011293 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768493011294 active site 768493011295 catalytic tetrad [active] 768493011296 manganese transport protein MntH; Reviewed; Region: PRK00701 768493011297 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 768493011298 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 768493011299 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 768493011300 Nucleoside recognition; Region: Gate; pfam07670 768493011301 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 768493011302 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 768493011303 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 768493011304 HIGH motif; other site 768493011305 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 768493011306 active site 768493011307 KMSKS motif; other site 768493011308 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 768493011309 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 768493011310 putative NAD(P) binding site [chemical binding]; other site 768493011311 active site 768493011312 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 768493011313 hydrophobic substrate binding pocket; other site 768493011314 Isochorismatase family; Region: Isochorismatase; pfam00857 768493011315 active site 768493011316 conserved cis-peptide bond; other site 768493011317 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 768493011318 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 768493011319 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 768493011320 acyl-activating enzyme (AAE) consensus motif; other site 768493011321 active site 768493011322 AMP binding site [chemical binding]; other site 768493011323 substrate binding site [chemical binding]; other site 768493011324 isochorismate synthase EntC; Provisional; Region: PRK15016 768493011325 chorismate binding enzyme; Region: Chorismate_bind; cl10555 768493011326 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 768493011327 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 768493011328 siderophore binding site; other site 768493011329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493011330 H+ Antiporter protein; Region: 2A0121; TIGR00900 768493011331 putative substrate translocation pore; other site 768493011332 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 768493011333 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 768493011334 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768493011335 ABC-ATPase subunit interface; other site 768493011336 dimer interface [polypeptide binding]; other site 768493011337 putative PBP binding regions; other site 768493011338 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 768493011339 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768493011340 ABC-ATPase subunit interface; other site 768493011341 dimer interface [polypeptide binding]; other site 768493011342 putative PBP binding regions; other site 768493011343 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 768493011344 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768493011345 Walker A/P-loop; other site 768493011346 ATP binding site [chemical binding]; other site 768493011347 Q-loop/lid; other site 768493011348 ABC transporter signature motif; other site 768493011349 Walker B; other site 768493011350 D-loop; other site 768493011351 H-loop/switch region; other site 768493011352 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 768493011353 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 768493011354 acyl-activating enzyme (AAE) consensus motif; other site 768493011355 AMP binding site [chemical binding]; other site 768493011356 MbtH-like protein; Region: MbtH; cl01279 768493011357 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 768493011358 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 768493011359 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 768493011360 outer membrane receptor FepA; Provisional; Region: PRK13524 768493011361 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768493011362 N-terminal plug; other site 768493011363 ligand-binding site [chemical binding]; other site 768493011364 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 768493011365 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 768493011366 peptide binding site [polypeptide binding]; other site 768493011367 acetolactate synthase; Reviewed; Region: PRK08617 768493011368 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768493011369 PYR/PP interface [polypeptide binding]; other site 768493011370 dimer interface [polypeptide binding]; other site 768493011371 TPP binding site [chemical binding]; other site 768493011372 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768493011373 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 768493011374 TPP-binding site [chemical binding]; other site 768493011375 dimer interface [polypeptide binding]; other site 768493011376 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 768493011377 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493011378 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493011379 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768493011380 putative effector binding pocket; other site 768493011381 dimerization interface [polypeptide binding]; other site 768493011382 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 768493011383 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 768493011384 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 768493011385 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 768493011386 FlxA-like protein; Region: FlxA; pfam14282 768493011387 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493011388 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493011389 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 768493011390 putative dimerization interface [polypeptide binding]; other site 768493011391 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 768493011392 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 768493011393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 768493011394 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 768493011395 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 768493011396 nucleotide binding pocket [chemical binding]; other site 768493011397 K-X-D-G motif; other site 768493011398 catalytic site [active] 768493011399 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 768493011400 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 768493011401 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 768493011402 Dimer interface [polypeptide binding]; other site 768493011403 BRCT sequence motif; other site 768493011404 cell division protein ZipA; Provisional; Region: PRK03427 768493011405 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 768493011406 FtsZ protein binding site [polypeptide binding]; other site 768493011407 putative sulfate transport protein CysZ; Validated; Region: PRK04949 768493011408 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 768493011409 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 768493011410 dimer interface [polypeptide binding]; other site 768493011411 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493011412 catalytic residue [active] 768493011413 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 768493011414 dimerization domain swap beta strand [polypeptide binding]; other site 768493011415 regulatory protein interface [polypeptide binding]; other site 768493011416 active site 768493011417 regulatory phosphorylation site [posttranslational modification]; other site 768493011418 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 768493011419 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 768493011420 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 768493011421 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 768493011422 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 768493011423 HPr interaction site; other site 768493011424 glycerol kinase (GK) interaction site [polypeptide binding]; other site 768493011425 active site 768493011426 phosphorylation site [posttranslational modification] 768493011427 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 768493011428 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768493011429 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768493011430 dimerization interface [polypeptide binding]; other site 768493011431 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768493011432 dimer interface [polypeptide binding]; other site 768493011433 phosphorylation site [posttranslational modification] 768493011434 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493011435 ATP binding site [chemical binding]; other site 768493011436 Mg2+ binding site [ion binding]; other site 768493011437 G-X-G motif; other site 768493011438 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768493011439 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493011440 active site 768493011441 phosphorylation site [posttranslational modification] 768493011442 intermolecular recognition site; other site 768493011443 dimerization interface [polypeptide binding]; other site 768493011444 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768493011445 DNA binding site [nucleotide binding] 768493011446 macrolide transporter subunit MacA; Provisional; Region: PRK11578 768493011447 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768493011448 HlyD family secretion protein; Region: HlyD_3; pfam13437 768493011449 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 768493011450 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768493011451 Walker A/P-loop; other site 768493011452 ATP binding site [chemical binding]; other site 768493011453 Q-loop/lid; other site 768493011454 ABC transporter signature motif; other site 768493011455 Walker B; other site 768493011456 D-loop; other site 768493011457 H-loop/switch region; other site 768493011458 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768493011459 FtsX-like permease family; Region: FtsX; pfam02687 768493011460 cysteine synthase B; Region: cysM; TIGR01138 768493011461 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 768493011462 dimer interface [polypeptide binding]; other site 768493011463 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493011464 catalytic residue [active] 768493011465 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 768493011466 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 768493011467 Walker A/P-loop; other site 768493011468 ATP binding site [chemical binding]; other site 768493011469 Q-loop/lid; other site 768493011470 ABC transporter signature motif; other site 768493011471 Walker B; other site 768493011472 D-loop; other site 768493011473 H-loop/switch region; other site 768493011474 TOBE-like domain; Region: TOBE_3; pfam12857 768493011475 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 768493011476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493011477 dimer interface [polypeptide binding]; other site 768493011478 conserved gate region; other site 768493011479 putative PBP binding loops; other site 768493011480 ABC-ATPase subunit interface; other site 768493011481 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 768493011482 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493011483 dimer interface [polypeptide binding]; other site 768493011484 conserved gate region; other site 768493011485 putative PBP binding loops; other site 768493011486 ABC-ATPase subunit interface; other site 768493011487 thiosulfate transporter subunit; Provisional; Region: PRK10852 768493011488 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 768493011489 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 768493011490 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 768493011491 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 768493011492 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 768493011493 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 768493011494 putative acetyltransferase; Provisional; Region: PRK03624 768493011495 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493011496 Coenzyme A binding pocket [chemical binding]; other site 768493011497 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 768493011498 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 768493011499 active site 768493011500 metal binding site [ion binding]; metal-binding site 768493011501 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 768493011502 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 768493011503 hypothetical protein; Validated; Region: PRK00124 768493011504 Protein of unknown function, DUF399; Region: DUF399; pfam04187 768493011505 S-methylmethionine transporter; Provisional; Region: PRK11387 768493011506 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 768493011507 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 768493011508 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 768493011509 Malic enzyme, N-terminal domain; Region: malic; pfam00390 768493011510 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 768493011511 putative NAD(P) binding site [chemical binding]; other site 768493011512 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 768493011513 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 768493011514 Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106 768493011515 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 768493011516 Glyco_18 domain; Region: Glyco_18; smart00636 768493011517 active site 768493011518 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 768493011519 transcriptional regulator, ArgP family; Region: argP; TIGR03298 768493011520 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493011521 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768493011522 dimerization interface [polypeptide binding]; other site 768493011523 Chitin binding domain; Region: Chitin_bind_3; pfam03067 768493011524 transaldolase-like protein; Provisional; Region: PTZ00411 768493011525 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 768493011526 active site 768493011527 dimer interface [polypeptide binding]; other site 768493011528 catalytic residue [active] 768493011529 transketolase; Reviewed; Region: PRK12753 768493011530 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 768493011531 TPP-binding site [chemical binding]; other site 768493011532 dimer interface [polypeptide binding]; other site 768493011533 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 768493011534 PYR/PP interface [polypeptide binding]; other site 768493011535 dimer interface [polypeptide binding]; other site 768493011536 TPP binding site [chemical binding]; other site 768493011537 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768493011538 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 768493011539 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 768493011540 dimer interface [polypeptide binding]; other site 768493011541 ADP-ribose binding site [chemical binding]; other site 768493011542 active site 768493011543 nudix motif; other site 768493011544 metal binding site [ion binding]; metal-binding site 768493011545 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 768493011546 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 768493011547 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 768493011548 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 768493011549 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 768493011550 [4Fe-4S] binding site [ion binding]; other site 768493011551 molybdopterin cofactor binding site; other site 768493011552 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 768493011553 molybdopterin cofactor binding site; other site 768493011554 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 768493011555 ferredoxin-type protein NapF; Region: napF; TIGR00402 768493011556 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768493011557 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 768493011558 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 768493011559 HAMP domain; Region: HAMP; pfam00672 768493011560 dimerization interface [polypeptide binding]; other site 768493011561 Histidine kinase; Region: HisKA_3; pfam07730 768493011562 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493011563 ATP binding site [chemical binding]; other site 768493011564 Mg2+ binding site [ion binding]; other site 768493011565 G-X-G motif; other site 768493011566 transcriptional regulator NarP; Provisional; Region: PRK10403 768493011567 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493011568 active site 768493011569 phosphorylation site [posttranslational modification] 768493011570 intermolecular recognition site; other site 768493011571 dimerization interface [polypeptide binding]; other site 768493011572 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768493011573 DNA binding residues [nucleotide binding] 768493011574 dimerization interface [polypeptide binding]; other site 768493011575 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4519 768493011576 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 768493011577 Protein export membrane protein; Region: SecD_SecF; cl14618 768493011578 putative outer membrane receptor; Provisional; Region: PRK13513 768493011579 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768493011580 N-terminal plug; other site 768493011581 ligand-binding site [chemical binding]; other site 768493011582 Uncharacterized conserved protein [Function unknown]; Region: COG3391 768493011583 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 768493011584 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768493011585 N-terminal plug; other site 768493011586 ligand-binding site [chemical binding]; other site 768493011587 Tetratrico peptide repeat; Region: TPR_5; pfam12688 768493011588 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768493011589 binding surface 768493011590 TPR motif; other site 768493011591 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493011592 Coenzyme A binding pocket [chemical binding]; other site 768493011593 Chorismate mutase type II; Region: CM_2; cl00693 768493011594 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768493011595 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 768493011596 ArsC family; Region: ArsC; pfam03960 768493011597 putative catalytic residues [active] 768493011598 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 768493011599 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 768493011600 metal binding site [ion binding]; metal-binding site 768493011601 dimer interface [polypeptide binding]; other site 768493011602 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 768493011603 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 768493011604 Uncharacterized protein family (UPF0370); Region: UPF0370; pfam13980 768493011605 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 768493011606 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 768493011607 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 768493011608 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 768493011609 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 768493011610 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 768493011611 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 768493011612 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 768493011613 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 768493011614 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 768493011615 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 768493011616 putative hydrolase; Provisional; Region: PRK11460 768493011617 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 768493011618 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 768493011619 Helicase; Region: Helicase_RecD; pfam05127 768493011620 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 768493011621 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 768493011622 Predicted metalloprotease [General function prediction only]; Region: COG2321 768493011623 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 768493011624 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 768493011625 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 768493011626 ATP binding site [chemical binding]; other site 768493011627 active site 768493011628 substrate binding site [chemical binding]; other site 768493011629 lipoprotein; Provisional; Region: PRK11679 768493011630 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 768493011631 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 768493011632 dihydrodipicolinate synthase; Region: dapA; TIGR00674 768493011633 dimer interface [polypeptide binding]; other site 768493011634 active site 768493011635 catalytic residue [active] 768493011636 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 768493011637 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 768493011638 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 768493011639 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 768493011640 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 768493011641 catalytic triad [active] 768493011642 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 768493011643 Domain of unknown function DUF20; Region: UPF0118; pfam01594 768493011644 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 768493011645 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 768493011646 MoaE homodimer interface [polypeptide binding]; other site 768493011647 MoaD interaction [polypeptide binding]; other site 768493011648 active site residues [active] 768493011649 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 768493011650 MoaE interaction surface [polypeptide binding]; other site 768493011651 MoeB interaction surface [polypeptide binding]; other site 768493011652 thiocarboxylated glycine; other site 768493011653 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 768493011654 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768493011655 FeS/SAM binding site; other site 768493011656 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 768493011657 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 768493011658 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 768493011659 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 768493011660 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 768493011661 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 768493011662 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 768493011663 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 768493011664 putative molybdopterin cofactor binding site [chemical binding]; other site 768493011665 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 768493011666 putative molybdopterin cofactor binding site; other site 768493011667 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 768493011668 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768493011669 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768493011670 putative DNA binding site [nucleotide binding]; other site 768493011671 putative Zn2+ binding site [ion binding]; other site 768493011672 AsnC family; Region: AsnC_trans_reg; pfam01037 768493011673 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 768493011674 Predicted transcriptional regulator [Transcription]; Region: COG1959 768493011675 Transcriptional regulator; Region: Rrf2; pfam02082 768493011676 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 768493011677 Peptidase family M48; Region: Peptidase_M48; pfam01435 768493011678 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 768493011679 ArsC family; Region: ArsC; pfam03960 768493011680 catalytic residues [active] 768493011681 DNA replication initiation factor; Provisional; Region: PRK08084 768493011682 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 768493011683 hypothetical protein; Provisional; Region: PRK10457 768493011684 uracil transporter; Provisional; Region: PRK10720 768493011685 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768493011686 active site 768493011687 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 768493011688 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 768493011689 dimerization interface [polypeptide binding]; other site 768493011690 putative ATP binding site [chemical binding]; other site 768493011691 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 768493011692 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 768493011693 active site 768493011694 substrate binding site [chemical binding]; other site 768493011695 cosubstrate binding site; other site 768493011696 catalytic site [active] 768493011697 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 768493011698 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 768493011699 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493011700 Coenzyme A binding pocket [chemical binding]; other site 768493011701 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3792 768493011702 haemagglutination activity domain; Region: Haemagg_act; pfam05860 768493011703 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 768493011704 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 768493011705 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 768493011706 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 768493011707 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 768493011708 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 768493011709 Walker A/P-loop; other site 768493011710 ATP binding site [chemical binding]; other site 768493011711 Q-loop/lid; other site 768493011712 ABC transporter signature motif; other site 768493011713 Walker B; other site 768493011714 D-loop; other site 768493011715 H-loop/switch region; other site 768493011716 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 768493011717 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 768493011718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493011719 dimer interface [polypeptide binding]; other site 768493011720 conserved gate region; other site 768493011721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 768493011722 ABC-ATPase subunit interface; other site 768493011723 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 768493011724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493011725 conserved gate region; other site 768493011726 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493011727 conserved gate region; other site 768493011728 putative PBP binding loops; other site 768493011729 ABC-ATPase subunit interface; other site 768493011730 polyphosphate kinase; Provisional; Region: PRK05443 768493011731 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 768493011732 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 768493011733 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 768493011734 domain interface [polypeptide binding]; other site 768493011735 active site 768493011736 catalytic site [active] 768493011737 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 768493011738 domain interface [polypeptide binding]; other site 768493011739 active site 768493011740 catalytic site [active] 768493011741 exopolyphosphatase; Provisional; Region: PRK10854 768493011742 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 768493011743 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 768493011744 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 768493011745 MgtE intracellular N domain; Region: MgtE_N; smart00924 768493011746 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 768493011747 Divalent cation transporter; Region: MgtE; pfam01769 768493011748 putative diguanylate cyclase; Provisional; Region: PRK09776 768493011749 MASE1; Region: MASE1; cl17823 768493011750 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768493011751 putative active site [active] 768493011752 heme pocket [chemical binding]; other site 768493011753 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768493011754 putative active site [active] 768493011755 heme pocket [chemical binding]; other site 768493011756 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768493011757 putative active site [active] 768493011758 heme pocket [chemical binding]; other site 768493011759 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768493011760 metal binding site [ion binding]; metal-binding site 768493011761 active site 768493011762 I-site; other site 768493011763 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768493011764 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 768493011765 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 768493011766 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 768493011767 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493011768 AlkA N-terminal domain; Region: AlkA_N; pfam06029 768493011769 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 768493011770 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 768493011771 minor groove reading motif; other site 768493011772 helix-hairpin-helix signature motif; other site 768493011773 substrate binding pocket [chemical binding]; other site 768493011774 active site 768493011775 putative chaperone; Provisional; Region: PRK11678 768493011776 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 768493011777 nucleotide binding site [chemical binding]; other site 768493011778 putative NEF/HSP70 interaction site [polypeptide binding]; other site 768493011779 SBD interface [polypeptide binding]; other site 768493011780 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768493011781 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768493011782 Predicted kinase [General function prediction only]; Region: COG0645 768493011783 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 768493011784 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768493011785 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768493011786 active site 768493011787 catalytic tetrad [active] 768493011788 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 768493011789 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768493011790 HlyD family secretion protein; Region: HlyD_3; pfam13437 768493011791 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 768493011792 Protein export membrane protein; Region: SecD_SecF; cl14618 768493011793 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 768493011794 putative transporter; Provisional; Region: PRK10504 768493011795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493011796 putative substrate translocation pore; other site 768493011797 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 768493011798 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768493011799 dimerization interface [polypeptide binding]; other site 768493011800 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768493011801 dimer interface [polypeptide binding]; other site 768493011802 phosphorylation site [posttranslational modification] 768493011803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493011804 ATP binding site [chemical binding]; other site 768493011805 Mg2+ binding site [ion binding]; other site 768493011806 G-X-G motif; other site 768493011807 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 768493011808 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493011809 active site 768493011810 phosphorylation site [posttranslational modification] 768493011811 intermolecular recognition site; other site 768493011812 dimerization interface [polypeptide binding]; other site 768493011813 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768493011814 DNA binding site [nucleotide binding] 768493011815 Uncharacterized conserved protein [Function unknown]; Region: COG3422 768493011816 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 768493011817 putative protease; Provisional; Region: PRK15452 768493011818 Peptidase family U32; Region: Peptidase_U32; pfam01136 768493011819 lipid kinase; Reviewed; Region: PRK13054 768493011820 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 768493011821 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 768493011822 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 768493011823 putative active site pocket [active] 768493011824 putative metal binding site [ion binding]; other site 768493011825 putative oxidoreductase; Provisional; Region: PRK10083 768493011826 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 768493011827 putative NAD(P) binding site [chemical binding]; other site 768493011828 catalytic Zn binding site [ion binding]; other site 768493011829 structural Zn binding site [ion binding]; other site 768493011830 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493011831 D-galactonate transporter; Region: 2A0114; TIGR00893 768493011832 putative substrate translocation pore; other site 768493011833 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 768493011834 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 768493011835 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 768493011836 Transcriptional regulators [Transcription]; Region: GntR; COG1802 768493011837 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768493011838 DNA-binding site [nucleotide binding]; DNA binding site 768493011839 FCD domain; Region: FCD; pfam07729 768493011840 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 768493011841 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 768493011842 putative active site; other site 768493011843 catalytic residue [active] 768493011844 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 768493011845 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 768493011846 putative active site [active] 768493011847 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 768493011848 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816 768493011849 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 768493011850 dimer interface [polypeptide binding]; other site 768493011851 substrate binding site [chemical binding]; other site 768493011852 ATP binding site [chemical binding]; other site 768493011853 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 768493011854 substrate binding site [chemical binding]; other site 768493011855 multimerization interface [polypeptide binding]; other site 768493011856 ATP binding site [chemical binding]; other site 768493011857 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 768493011858 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493011859 Coenzyme A binding pocket [chemical binding]; other site 768493011860 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493011861 S-adenosylmethionine binding site [chemical binding]; other site 768493011862 Predicted transcriptional regulators [Transcription]; Region: COG1733 768493011863 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 768493011864 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 768493011865 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768493011866 RNA binding surface [nucleotide binding]; other site 768493011867 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 768493011868 probable active site [active] 768493011869 Autotransporter beta-domain; Region: Autotransporter; pfam03797 768493011870 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768493011871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493011872 active site 768493011873 phosphorylation site [posttranslational modification] 768493011874 intermolecular recognition site; other site 768493011875 dimerization interface [polypeptide binding]; other site 768493011876 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768493011877 DNA binding residues [nucleotide binding] 768493011878 dimerization interface [polypeptide binding]; other site 768493011879 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768493011880 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768493011881 dimer interface [polypeptide binding]; other site 768493011882 phosphorylation site [posttranslational modification] 768493011883 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493011884 ATP binding site [chemical binding]; other site 768493011885 Mg2+ binding site [ion binding]; other site 768493011886 G-X-G motif; other site 768493011887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493011888 Response regulator receiver domain; Region: Response_reg; pfam00072 768493011889 active site 768493011890 phosphorylation site [posttranslational modification] 768493011891 intermolecular recognition site; other site 768493011892 dimerization interface [polypeptide binding]; other site 768493011893 enoyl-CoA hydratase; Provisional; Region: PRK06688 768493011894 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768493011895 substrate binding site [chemical binding]; other site 768493011896 oxyanion hole (OAH) forming residues; other site 768493011897 trimer interface [polypeptide binding]; other site 768493011898 Predicted transcriptional regulators [Transcription]; Region: COG1733 768493011899 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 768493011900 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768493011901 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493011902 Coenzyme A binding pocket [chemical binding]; other site 768493011903 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768493011904 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768493011905 putative DNA binding site [nucleotide binding]; other site 768493011906 putative Zn2+ binding site [ion binding]; other site 768493011907 AsnC family; Region: AsnC_trans_reg; pfam01037 768493011908 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 768493011909 Bacterial sugar transferase; Region: Bac_transf; pfam02397 768493011910 Protein of unknown function (DUF342); Region: DUF342; pfam03961 768493011911 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 768493011912 GMP synthase; Reviewed; Region: guaA; PRK00074 768493011913 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 768493011914 AMP/PPi binding site [chemical binding]; other site 768493011915 candidate oxyanion hole; other site 768493011916 catalytic triad [active] 768493011917 potential glutamine specificity residues [chemical binding]; other site 768493011918 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 768493011919 ATP Binding subdomain [chemical binding]; other site 768493011920 Ligand Binding sites [chemical binding]; other site 768493011921 Dimerization subdomain; other site 768493011922 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 768493011923 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 768493011924 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 768493011925 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 768493011926 active site 768493011927 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 768493011928 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 768493011929 generic binding surface II; other site 768493011930 generic binding surface I; other site 768493011931 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 768493011932 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 768493011933 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 768493011934 putative active site [active] 768493011935 putative catalytic site [active] 768493011936 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493011937 D-galactonate transporter; Region: 2A0114; TIGR00893 768493011938 putative substrate translocation pore; other site 768493011939 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768493011940 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768493011941 DNA binding site [nucleotide binding] 768493011942 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 768493011943 ligand binding site [chemical binding]; other site 768493011944 dimerization interface [polypeptide binding]; other site 768493011945 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 768493011946 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 768493011947 active site 768493011948 Zn binding site [ion binding]; other site 768493011949 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 768493011950 Predicted permeases [General function prediction only]; Region: COG0679 768493011951 GTP-binding protein Der; Reviewed; Region: PRK00093 768493011952 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 768493011953 G1 box; other site 768493011954 GTP/Mg2+ binding site [chemical binding]; other site 768493011955 Switch I region; other site 768493011956 G2 box; other site 768493011957 Switch II region; other site 768493011958 G3 box; other site 768493011959 G4 box; other site 768493011960 G5 box; other site 768493011961 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 768493011962 G1 box; other site 768493011963 GTP/Mg2+ binding site [chemical binding]; other site 768493011964 Switch I region; other site 768493011965 G2 box; other site 768493011966 G3 box; other site 768493011967 Switch II region; other site 768493011968 G4 box; other site 768493011969 G5 box; other site 768493011970 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 768493011971 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 768493011972 Trp docking motif [polypeptide binding]; other site 768493011973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 768493011974 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 768493011975 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 768493011976 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 768493011977 dimer interface [polypeptide binding]; other site 768493011978 motif 1; other site 768493011979 active site 768493011980 motif 2; other site 768493011981 motif 3; other site 768493011982 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 768493011983 anticodon binding site; other site 768493011984 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 768493011985 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 768493011986 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 768493011987 cytoskeletal protein RodZ; Provisional; Region: PRK10856 768493011988 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768493011989 non-specific DNA binding site [nucleotide binding]; other site 768493011990 salt bridge; other site 768493011991 sequence-specific DNA binding site [nucleotide binding]; other site 768493011992 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 768493011993 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 768493011994 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768493011995 binding surface 768493011996 TPR motif; other site 768493011997 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 768493011998 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768493011999 FeS/SAM binding site; other site 768493012000 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 768493012001 active site 768493012002 multimer interface [polypeptide binding]; other site 768493012003 penicillin-binding protein 1C; Provisional; Region: PRK11240 768493012004 Transglycosylase; Region: Transgly; pfam00912 768493012005 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 768493012006 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 768493012007 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 768493012008 MG2 domain; Region: A2M_N; pfam01835 768493012009 Alpha-2-macroglobulin family; Region: A2M; pfam00207 768493012010 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 768493012011 surface patch; other site 768493012012 thioester region; other site 768493012013 specificity defining residues; other site 768493012014 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 768493012015 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768493012016 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768493012017 active site turn [active] 768493012018 phosphorylation site [posttranslational modification] 768493012019 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 768493012020 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 768493012021 NAD binding site [chemical binding]; other site 768493012022 sugar binding site [chemical binding]; other site 768493012023 divalent metal binding site [ion binding]; other site 768493012024 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 768493012025 dimer interface [polypeptide binding]; other site 768493012026 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 768493012027 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768493012028 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768493012029 putative active site [active] 768493012030 SseB protein; Region: SseB; pfam07179 768493012031 aminopeptidase B; Provisional; Region: PRK05015 768493012032 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 768493012033 interface (dimer of trimers) [polypeptide binding]; other site 768493012034 Substrate-binding/catalytic site; other site 768493012035 Zn-binding sites [ion binding]; other site 768493012036 hypothetical protein; Provisional; Region: PRK10721 768493012037 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 768493012038 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768493012039 catalytic loop [active] 768493012040 iron binding site [ion binding]; other site 768493012041 chaperone protein HscA; Provisional; Region: hscA; PRK05183 768493012042 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 768493012043 nucleotide binding site [chemical binding]; other site 768493012044 putative NEF/HSP70 interaction site [polypeptide binding]; other site 768493012045 SBD interface [polypeptide binding]; other site 768493012046 co-chaperone HscB; Provisional; Region: hscB; PRK05014 768493012047 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 768493012048 HSP70 interaction site [polypeptide binding]; other site 768493012049 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 768493012050 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 768493012051 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 768493012052 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 768493012053 trimerization site [polypeptide binding]; other site 768493012054 active site 768493012055 cysteine desulfurase; Provisional; Region: PRK14012 768493012056 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 768493012057 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768493012058 catalytic residue [active] 768493012059 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 768493012060 Rrf2 family protein; Region: rrf2_super; TIGR00738 768493012061 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 768493012062 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 768493012063 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 768493012064 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 768493012065 active site 768493012066 dimerization interface [polypeptide binding]; other site 768493012067 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 768493012068 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 768493012069 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 768493012070 PRD domain; Region: PRD; pfam00874 768493012071 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 768493012072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493012073 putative substrate translocation pore; other site 768493012074 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 768493012075 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 768493012076 dimer interface [polypeptide binding]; other site 768493012077 active site 768493012078 glycine-pyridoxal phosphate binding site [chemical binding]; other site 768493012079 folate binding site [chemical binding]; other site 768493012080 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 768493012081 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 768493012082 heme-binding site [chemical binding]; other site 768493012083 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 768493012084 FAD binding pocket [chemical binding]; other site 768493012085 FAD binding motif [chemical binding]; other site 768493012086 phosphate binding motif [ion binding]; other site 768493012087 beta-alpha-beta structure motif; other site 768493012088 NAD binding pocket [chemical binding]; other site 768493012089 Heme binding pocket [chemical binding]; other site 768493012090 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 768493012091 Nitrogen regulatory protein P-II; Region: P-II; smart00938 768493012092 NAD synthetase; Provisional; Region: PRK13981 768493012093 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 768493012094 multimer interface [polypeptide binding]; other site 768493012095 active site 768493012096 catalytic triad [active] 768493012097 protein interface 1 [polypeptide binding]; other site 768493012098 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 768493012099 homodimer interface [polypeptide binding]; other site 768493012100 NAD binding pocket [chemical binding]; other site 768493012101 ATP binding pocket [chemical binding]; other site 768493012102 Mg binding site [ion binding]; other site 768493012103 active-site loop [active] 768493012104 response regulator GlrR; Provisional; Region: PRK15115 768493012105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493012106 active site 768493012107 phosphorylation site [posttranslational modification] 768493012108 intermolecular recognition site; other site 768493012109 dimerization interface [polypeptide binding]; other site 768493012110 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768493012111 Walker A motif; other site 768493012112 ATP binding site [chemical binding]; other site 768493012113 Walker B motif; other site 768493012114 arginine finger; other site 768493012115 hypothetical protein; Provisional; Region: PRK10722 768493012116 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768493012117 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768493012118 dimer interface [polypeptide binding]; other site 768493012119 phosphorylation site [posttranslational modification] 768493012120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493012121 ATP binding site [chemical binding]; other site 768493012122 Mg2+ binding site [ion binding]; other site 768493012123 G-X-G motif; other site 768493012124 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 768493012125 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 768493012126 dimerization interface [polypeptide binding]; other site 768493012127 ATP binding site [chemical binding]; other site 768493012128 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 768493012129 dimerization interface [polypeptide binding]; other site 768493012130 ATP binding site [chemical binding]; other site 768493012131 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 768493012132 putative active site [active] 768493012133 catalytic triad [active] 768493012134 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 768493012135 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768493012136 substrate binding pocket [chemical binding]; other site 768493012137 membrane-bound complex binding site; other site 768493012138 hinge residues; other site 768493012139 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768493012140 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768493012141 catalytic residue [active] 768493012142 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 768493012143 nucleoside/Zn binding site; other site 768493012144 dimer interface [polypeptide binding]; other site 768493012145 catalytic motif [active] 768493012146 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 768493012147 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768493012148 active site turn [active] 768493012149 phosphorylation site [posttranslational modification] 768493012150 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768493012151 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 768493012152 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 768493012153 putative active site [active] 768493012154 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768493012155 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 768493012156 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768493012157 putative active site [active] 768493012158 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 768493012159 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 768493012160 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 768493012161 active site 768493012162 hydrophilic channel; other site 768493012163 dimerization interface [polypeptide binding]; other site 768493012164 catalytic residues [active] 768493012165 active site lid [active] 768493012166 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 768493012167 Recombination protein O N terminal; Region: RecO_N; pfam11967 768493012168 Recombination protein O C terminal; Region: RecO_C; pfam02565 768493012169 GTPase Era; Reviewed; Region: era; PRK00089 768493012170 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 768493012171 G1 box; other site 768493012172 GTP/Mg2+ binding site [chemical binding]; other site 768493012173 Switch I region; other site 768493012174 G2 box; other site 768493012175 Switch II region; other site 768493012176 G3 box; other site 768493012177 G4 box; other site 768493012178 G5 box; other site 768493012179 KH domain; Region: KH_2; pfam07650 768493012180 ribonuclease III; Reviewed; Region: rnc; PRK00102 768493012181 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 768493012182 dimerization interface [polypeptide binding]; other site 768493012183 active site 768493012184 metal binding site [ion binding]; metal-binding site 768493012185 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 768493012186 dsRNA binding site [nucleotide binding]; other site 768493012187 signal peptidase I; Provisional; Region: PRK10861 768493012188 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 768493012189 Catalytic site [active] 768493012190 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 768493012191 GTP-binding protein LepA; Provisional; Region: PRK05433 768493012192 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 768493012193 G1 box; other site 768493012194 putative GEF interaction site [polypeptide binding]; other site 768493012195 GTP/Mg2+ binding site [chemical binding]; other site 768493012196 Switch I region; other site 768493012197 G2 box; other site 768493012198 G3 box; other site 768493012199 Switch II region; other site 768493012200 G4 box; other site 768493012201 G5 box; other site 768493012202 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 768493012203 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 768493012204 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 768493012205 SoxR reducing system protein RseC; Provisional; Region: PRK10862 768493012206 anti-sigma E factor; Provisional; Region: rseB; PRK09455 768493012207 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 768493012208 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 768493012209 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 768493012210 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 768493012211 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 768493012212 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768493012213 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768493012214 DNA binding residues [nucleotide binding] 768493012215 L-aspartate oxidase; Provisional; Region: PRK09077 768493012216 L-aspartate oxidase; Provisional; Region: PRK06175 768493012217 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 768493012218 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 768493012219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493012220 S-adenosylmethionine binding site [chemical binding]; other site 768493012221 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 768493012222 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 768493012223 ATP binding site [chemical binding]; other site 768493012224 Mg++ binding site [ion binding]; other site 768493012225 motif III; other site 768493012226 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768493012227 nucleotide binding region [chemical binding]; other site 768493012228 ATP-binding site [chemical binding]; other site 768493012229 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 768493012230 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 768493012231 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 768493012232 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 768493012233 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 768493012234 ligand binding site [chemical binding]; other site 768493012235 active site 768493012236 UGI interface [polypeptide binding]; other site 768493012237 catalytic site [active] 768493012238 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 768493012239 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 768493012240 dimer interface [polypeptide binding]; other site 768493012241 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 768493012242 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 768493012243 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 768493012244 recombination and repair protein; Provisional; Region: PRK10869 768493012245 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 768493012246 Walker A/P-loop; other site 768493012247 ATP binding site [chemical binding]; other site 768493012248 Q-loop/lid; other site 768493012249 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 768493012250 ABC transporter signature motif; other site 768493012251 Walker B; other site 768493012252 D-loop; other site 768493012253 H-loop/switch region; other site 768493012254 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 768493012255 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 768493012256 hypothetical protein; Validated; Region: PRK01777 768493012257 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 768493012258 putative coenzyme Q binding site [chemical binding]; other site 768493012259 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 768493012260 SmpB-tmRNA interface; other site 768493012261 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493012262 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493012263 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768493012264 dimerization interface [polypeptide binding]; other site 768493012265 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 768493012266 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 768493012267 potential catalytic triad [active] 768493012268 conserved cys residue [active] 768493012269 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768493012270 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768493012271 active site 768493012272 catalytic tetrad [active] 768493012273 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 768493012274 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 768493012275 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 768493012276 Uncharacterized conserved protein [Function unknown]; Region: COG1359 768493012277 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 768493012278 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 768493012279 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 768493012280 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 768493012281 putative NAD(P) binding site [chemical binding]; other site 768493012282 Predicted transcriptional regulator [Transcription]; Region: COG2378 768493012283 HTH domain; Region: HTH_11; pfam08279 768493012284 WYL domain; Region: WYL; cl14852 768493012285 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493012286 Coenzyme A binding pocket [chemical binding]; other site 768493012287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493012288 S-adenosylmethionine binding site [chemical binding]; other site 768493012289 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 768493012290 Predicted acetyltransferase [General function prediction only]; Region: COG2388 768493012291 Predicted membrane protein [Function unknown]; Region: COG2259 768493012292 MbeD/MobD like; Region: MbeD_MobD; pfam04899 768493012293 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 768493012294 hypothetical protein; Provisional; Region: PRK10556 768493012295 major facilitator superfamily transporter; Provisional; Region: PRK05122 768493012296 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493012297 putative substrate translocation pore; other site 768493012298 Helix-turn-helix domain; Region: HTH_18; pfam12833 768493012299 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493012300 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 768493012301 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493012302 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493012303 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768493012304 putative effector binding pocket; other site 768493012305 dimerization interface [polypeptide binding]; other site 768493012306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493012307 putative substrate translocation pore; other site 768493012308 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493012309 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 768493012310 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 768493012311 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768493012312 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768493012313 DNA-binding site [nucleotide binding]; DNA binding site 768493012314 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768493012315 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493012316 homodimer interface [polypeptide binding]; other site 768493012317 catalytic residue [active] 768493012318 Uncharacterized conserved protein [Function unknown]; Region: COG2128 768493012319 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 768493012320 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 768493012321 catalytic residues [active] 768493012322 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 768493012323 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 768493012324 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 768493012325 Class I ribonucleotide reductase; Region: RNR_I; cd01679 768493012326 active site 768493012327 dimer interface [polypeptide binding]; other site 768493012328 catalytic residues [active] 768493012329 effector binding site; other site 768493012330 R2 peptide binding site; other site 768493012331 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 768493012332 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 768493012333 dimer interface [polypeptide binding]; other site 768493012334 putative radical transfer pathway; other site 768493012335 diiron center [ion binding]; other site 768493012336 tyrosyl radical; other site 768493012337 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 768493012338 HicB family; Region: HicB; pfam05534 768493012339 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 768493012340 short chain dehydrogenase; Provisional; Region: PRK12937 768493012341 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 768493012342 NADP binding site [chemical binding]; other site 768493012343 homodimer interface [polypeptide binding]; other site 768493012344 active site 768493012345 substrate binding site [chemical binding]; other site 768493012346 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493012347 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493012348 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 768493012349 putative effector binding pocket; other site 768493012350 putative dimerization interface [polypeptide binding]; other site 768493012351 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 768493012352 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 768493012353 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 768493012354 active site 768493012355 nucleophile elbow; other site 768493012356 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 768493012357 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 768493012358 PAS domain; Region: PAS; smart00091 768493012359 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493012360 ATP binding site [chemical binding]; other site 768493012361 Mg2+ binding site [ion binding]; other site 768493012362 G-X-G motif; other site 768493012363 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 768493012364 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493012365 active site 768493012366 phosphorylation site [posttranslational modification] 768493012367 intermolecular recognition site; other site 768493012368 dimerization interface [polypeptide binding]; other site 768493012369 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 768493012370 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 768493012371 Walker A/P-loop; other site 768493012372 ATP binding site [chemical binding]; other site 768493012373 Q-loop/lid; other site 768493012374 ABC transporter signature motif; other site 768493012375 Walker B; other site 768493012376 D-loop; other site 768493012377 H-loop/switch region; other site 768493012378 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 768493012379 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 768493012380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493012381 dimer interface [polypeptide binding]; other site 768493012382 conserved gate region; other site 768493012383 putative PBP binding loops; other site 768493012384 ABC-ATPase subunit interface; other site 768493012385 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 768493012386 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 768493012387 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 768493012388 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 768493012389 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493012390 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493012391 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 768493012392 putative dimerization interface [polypeptide binding]; other site 768493012393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493012394 putative substrate translocation pore; other site 768493012395 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768493012396 transcriptional repressor MprA; Provisional; Region: PRK10870 768493012397 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768493012398 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 768493012399 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 768493012400 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768493012401 HlyD family secretion protein; Region: HlyD_3; pfam13437 768493012402 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 768493012403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493012404 putative substrate translocation pore; other site 768493012405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493012406 putative methyltransferase; Provisional; Region: PRK10864 768493012407 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 768493012408 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 768493012409 thioredoxin 2; Provisional; Region: PRK10996 768493012410 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 768493012411 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 768493012412 catalytic residues [active] 768493012413 Uncharacterized conserved protein [Function unknown]; Region: COG3148 768493012414 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 768493012415 CoA binding domain; Region: CoA_binding_2; pfam13380 768493012416 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 768493012417 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 768493012418 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768493012419 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493012420 Coenzyme A binding pocket [chemical binding]; other site 768493012421 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 768493012422 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 768493012423 domain interface [polypeptide binding]; other site 768493012424 putative active site [active] 768493012425 catalytic site [active] 768493012426 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 768493012427 domain interface [polypeptide binding]; other site 768493012428 putative active site [active] 768493012429 catalytic site [active] 768493012430 lipoprotein; Provisional; Region: PRK10759 768493012431 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 768493012432 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493012433 putative substrate translocation pore; other site 768493012434 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 768493012435 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768493012436 active site 768493012437 motif I; other site 768493012438 motif II; other site 768493012439 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 768493012440 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 768493012441 Walker A/P-loop; other site 768493012442 ATP binding site [chemical binding]; other site 768493012443 Q-loop/lid; other site 768493012444 ABC transporter signature motif; other site 768493012445 Walker B; other site 768493012446 D-loop; other site 768493012447 H-loop/switch region; other site 768493012448 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 768493012449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493012450 dimer interface [polypeptide binding]; other site 768493012451 conserved gate region; other site 768493012452 ABC-ATPase subunit interface; other site 768493012453 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 768493012454 lipoprotein, YaeC family; Region: TIGR00363 768493012455 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 768493012456 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 768493012457 homodimer interaction site [polypeptide binding]; other site 768493012458 cofactor binding site; other site 768493012459 prolyl-tRNA synthetase; Provisional; Region: PRK09194 768493012460 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 768493012461 dimer interface [polypeptide binding]; other site 768493012462 motif 1; other site 768493012463 active site 768493012464 motif 2; other site 768493012465 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 768493012466 putative deacylase active site [active] 768493012467 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 768493012468 active site 768493012469 motif 3; other site 768493012470 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 768493012471 anticodon binding site; other site 768493012472 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 768493012473 NlpE N-terminal domain; Region: NlpE; pfam04170 768493012474 hypothetical protein; Provisional; Region: PRK09256 768493012475 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 768493012476 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 768493012477 hypothetical protein; Provisional; Region: PRK04964 768493012478 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 768493012479 Cytochrome c; Region: Cytochrom_C; cl11414 768493012480 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 768493012481 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 768493012482 Ligand Binding Site [chemical binding]; other site 768493012483 TilS substrate binding domain; Region: TilS; pfam09179 768493012484 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 768493012485 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 768493012486 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768493012487 putative metal binding site [ion binding]; other site 768493012488 lysine decarboxylase LdcC; Provisional; Region: PRK15399 768493012489 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 768493012490 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 768493012491 homodimer interface [polypeptide binding]; other site 768493012492 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493012493 catalytic residue [active] 768493012494 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 768493012495 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 768493012496 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 768493012497 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 768493012498 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 768493012499 putative active site [active] 768493012500 putative PHP Thumb interface [polypeptide binding]; other site 768493012501 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 768493012502 generic binding surface II; other site 768493012503 generic binding surface I; other site 768493012504 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 768493012505 RNA/DNA hybrid binding site [nucleotide binding]; other site 768493012506 active site 768493012507 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 768493012508 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 768493012509 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 768493012510 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 768493012511 active site 768493012512 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 768493012513 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 768493012514 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 768493012515 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 768493012516 trimer interface [polypeptide binding]; other site 768493012517 active site 768493012518 UDP-GlcNAc binding site [chemical binding]; other site 768493012519 lipid binding site [chemical binding]; lipid-binding site 768493012520 periplasmic chaperone; Provisional; Region: PRK10780 768493012521 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 768493012522 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 768493012523 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768493012524 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768493012525 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768493012526 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768493012527 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768493012528 Surface antigen; Region: Bac_surface_Ag; pfam01103 768493012529 zinc metallopeptidase RseP; Provisional; Region: PRK10779 768493012530 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 768493012531 active site 768493012532 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 768493012533 protein binding site [polypeptide binding]; other site 768493012534 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 768493012535 protein binding site [polypeptide binding]; other site 768493012536 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 768493012537 putative substrate binding region [chemical binding]; other site 768493012538 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 768493012539 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 768493012540 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 768493012541 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 768493012542 catalytic residue [active] 768493012543 putative FPP diphosphate binding site; other site 768493012544 putative FPP binding hydrophobic cleft; other site 768493012545 dimer interface [polypeptide binding]; other site 768493012546 putative IPP diphosphate binding site; other site 768493012547 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 768493012548 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 768493012549 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 768493012550 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 768493012551 ribosome recycling factor; Reviewed; Region: frr; PRK00083 768493012552 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 768493012553 hinge region; other site 768493012554 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 768493012555 putative nucleotide binding site [chemical binding]; other site 768493012556 uridine monophosphate binding site [chemical binding]; other site 768493012557 homohexameric interface [polypeptide binding]; other site 768493012558 elongation factor Ts; Provisional; Region: tsf; PRK09377 768493012559 UBA/TS-N domain; Region: UBA; pfam00627 768493012560 Elongation factor TS; Region: EF_TS; pfam00889 768493012561 Elongation factor TS; Region: EF_TS; pfam00889 768493012562 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 768493012563 rRNA interaction site [nucleotide binding]; other site 768493012564 S8 interaction site; other site 768493012565 putative laminin-1 binding site; other site 768493012566 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 768493012567 active site 768493012568 PII uridylyl-transferase; Provisional; Region: PRK05007 768493012569 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 768493012570 metal binding triad; other site 768493012571 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 768493012572 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768493012573 Zn2+ binding site [ion binding]; other site 768493012574 Mg2+ binding site [ion binding]; other site 768493012575 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 768493012576 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 768493012577 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 768493012578 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 768493012579 trimer interface [polypeptide binding]; other site 768493012580 active site 768493012581 substrate binding site [chemical binding]; other site 768493012582 CoA binding site [chemical binding]; other site 768493012583 hypothetical protein; Provisional; Region: PRK13677 768493012584 flavodoxin; Provisional; Region: PRK08105 768493012585 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 768493012586 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 768493012587 probable active site [active] 768493012588 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 768493012589 benzoate transport; Region: 2A0115; TIGR00895 768493012590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493012591 putative substrate translocation pore; other site 768493012592 SecY interacting protein Syd; Provisional; Region: PRK04968 768493012593 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 768493012594 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 768493012595 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 768493012596 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 768493012597 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 768493012598 flap endonuclease-like protein; Provisional; Region: PRK09482 768493012599 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 768493012600 active site 768493012601 metal binding site 1 [ion binding]; metal-binding site 768493012602 putative 5' ssDNA interaction site; other site 768493012603 metal binding site 3; metal-binding site 768493012604 metal binding site 2 [ion binding]; metal-binding site 768493012605 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 768493012606 putative DNA binding site [nucleotide binding]; other site 768493012607 putative metal binding site [ion binding]; other site 768493012608 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 768493012609 FtsJ-like methyltransferase; Region: FtsJ; cl17430 768493012610 hypothetical protein; Provisional; Region: PRK10873 768493012611 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768493012612 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493012613 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 768493012614 dimerization interface [polypeptide binding]; other site 768493012615 substrate binding pocket [chemical binding]; other site 768493012616 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 768493012617 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 768493012618 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 768493012619 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768493012620 catalytic residue [active] 768493012621 cysteine desulfurase, sulfur acceptor subunit CsdE; Region: FeS_syn_CsdE; TIGR03391 768493012622 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 768493012623 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 768493012624 putative ATP binding site [chemical binding]; other site 768493012625 putative substrate interface [chemical binding]; other site 768493012626 murein transglycosylase A; Provisional; Region: mltA; PRK11162 768493012627 MltA specific insert domain; Region: MltA; smart00925 768493012628 3D domain; Region: 3D; pfam06725 768493012629 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 768493012630 AMIN domain; Region: AMIN; pfam11741 768493012631 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 768493012632 active site 768493012633 metal binding site [ion binding]; metal-binding site 768493012634 N-acetylglutamate synthase; Validated; Region: PRK05279 768493012635 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 768493012636 putative feedback inhibition sensing region; other site 768493012637 putative nucleotide binding site [chemical binding]; other site 768493012638 putative substrate binding site [chemical binding]; other site 768493012639 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493012640 Coenzyme A binding pocket [chemical binding]; other site 768493012641 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 768493012642 AAA domain; Region: AAA_30; pfam13604 768493012643 Family description; Region: UvrD_C_2; pfam13538 768493012644 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 768493012645 protease3; Provisional; Region: PRK15101 768493012646 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 768493012647 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 768493012648 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 768493012649 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 768493012650 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 768493012651 hypothetical protein; Provisional; Region: PRK10332 768493012652 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 768493012653 Protein of unknown function (DUF2509); Region: DUF2509; cl11672 768493012654 hypothetical protein; Provisional; Region: PRK10557 768493012655 hypothetical protein; Provisional; Region: PRK10506 768493012656 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 768493012657 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 768493012658 thymidylate synthase; Reviewed; Region: thyA; PRK01827 768493012659 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 768493012660 dimerization interface [polypeptide binding]; other site 768493012661 active site 768493012662 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 768493012663 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 768493012664 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 768493012665 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 768493012666 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 768493012667 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 768493012668 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 768493012669 putative active site [active] 768493012670 Ap4A binding site [chemical binding]; other site 768493012671 nudix motif; other site 768493012672 putative metal binding site [ion binding]; other site 768493012673 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 768493012674 putative DNA-binding cleft [nucleotide binding]; other site 768493012675 putative DNA clevage site; other site 768493012676 molecular lever; other site 768493012677 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 768493012678 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 768493012679 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768493012680 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768493012681 active site 768493012682 catalytic tetrad [active] 768493012683 lysophospholipid transporter LplT; Provisional; Region: PRK11195 768493012684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493012685 putative substrate translocation pore; other site 768493012686 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 768493012687 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 768493012688 putative acyl-acceptor binding pocket; other site 768493012689 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 768493012690 acyl-activating enzyme (AAE) consensus motif; other site 768493012691 putative AMP binding site [chemical binding]; other site 768493012692 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 768493012693 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 768493012694 molybdopterin cofactor binding site [chemical binding]; other site 768493012695 substrate binding site [chemical binding]; other site 768493012696 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 768493012697 molybdopterin cofactor binding site; other site 768493012698 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 768493012699 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768493012700 DNA binding site [nucleotide binding] 768493012701 domain linker motif; other site 768493012702 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 768493012703 dimerization interface (closed form) [polypeptide binding]; other site 768493012704 ligand binding site [chemical binding]; other site 768493012705 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493012706 Coenzyme A binding pocket [chemical binding]; other site 768493012707 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768493012708 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768493012709 DNA binding site [nucleotide binding] 768493012710 domain linker motif; other site 768493012711 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 768493012712 dimerization interface (closed form) [polypeptide binding]; other site 768493012713 ligand binding site [chemical binding]; other site 768493012714 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768493012715 sequence-specific DNA binding site [nucleotide binding]; other site 768493012716 salt bridge; other site 768493012717 diaminopimelate decarboxylase; Provisional; Region: PRK11165 768493012718 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 768493012719 active site 768493012720 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768493012721 substrate binding site [chemical binding]; other site 768493012722 catalytic residues [active] 768493012723 dimer interface [polypeptide binding]; other site 768493012724 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 768493012725 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493012726 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768493012727 dimerization interface [polypeptide binding]; other site 768493012728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493012729 putative substrate translocation pore; other site 768493012730 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768493012731 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493012732 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493012733 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768493012734 putative effector binding pocket; other site 768493012735 dimerization interface [polypeptide binding]; other site 768493012736 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 768493012737 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 768493012738 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 768493012739 catalytic residues [active] 768493012740 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 768493012741 TPR motif; other site 768493012742 binding surface 768493012743 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 768493012744 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 768493012745 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 768493012746 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 768493012747 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 768493012748 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 768493012749 Walker A/P-loop; other site 768493012750 ATP binding site [chemical binding]; other site 768493012751 Q-loop/lid; other site 768493012752 ABC transporter signature motif; other site 768493012753 Walker B; other site 768493012754 D-loop; other site 768493012755 H-loop/switch region; other site 768493012756 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768493012757 active site 768493012758 DNA binding site [nucleotide binding] 768493012759 Int/Topo IB signature motif; other site 768493012760 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768493012761 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768493012762 DNA binding residues [nucleotide binding] 768493012763 dimerization interface [polypeptide binding]; other site 768493012764 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768493012765 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 768493012766 intermolecular recognition site; other site 768493012767 active site 768493012768 dimerization interface [polypeptide binding]; other site 768493012769 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768493012770 DNA binding residues [nucleotide binding] 768493012771 dimerization interface [polypeptide binding]; other site 768493012772 Fimbrial protein; Region: Fimbrial; cl01416 768493012773 Fimbrial protein; Region: Fimbrial; cl01416 768493012774 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 768493012775 PapC N-terminal domain; Region: PapC_N; pfam13954 768493012776 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 768493012777 PapC C-terminal domain; Region: PapC_C; pfam13953 768493012778 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 768493012779 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 768493012780 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 768493012781 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 768493012782 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768493012783 active site 768493012784 DNA binding site [nucleotide binding] 768493012785 Int/Topo IB signature motif; other site 768493012786 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768493012787 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 768493012788 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 768493012789 dimer interface [polypeptide binding]; other site 768493012790 active site 768493012791 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 768493012792 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 768493012793 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768493012794 Walker A/P-loop; other site 768493012795 ATP binding site [chemical binding]; other site 768493012796 Q-loop/lid; other site 768493012797 ABC transporter signature motif; other site 768493012798 Walker B; other site 768493012799 D-loop; other site 768493012800 H-loop/switch region; other site 768493012801 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768493012802 FtsX-like permease family; Region: FtsX; pfam02687 768493012803 macrolide transporter subunit MacA; Provisional; Region: PRK11578 768493012804 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768493012805 HlyD family secretion protein; Region: HlyD_3; pfam13437 768493012806 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 768493012807 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 768493012808 putative active site [active] 768493012809 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768493012810 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768493012811 Walker A/P-loop; other site 768493012812 ATP binding site [chemical binding]; other site 768493012813 Q-loop/lid; other site 768493012814 ABC transporter signature motif; other site 768493012815 Walker B; other site 768493012816 D-loop; other site 768493012817 H-loop/switch region; other site 768493012818 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 768493012819 catalytic residues [active] 768493012820 hinge region; other site 768493012821 alpha helical domain; other site 768493012822 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493012823 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493012824 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768493012825 putative effector binding pocket; other site 768493012826 dimerization interface [polypeptide binding]; other site 768493012827 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 768493012828 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 768493012829 phosphate binding site [ion binding]; other site 768493012830 BCCT family transporter; Region: BCCT; pfam02028 768493012831 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 768493012832 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768493012833 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 768493012834 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493012835 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493012836 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768493012837 putative effector binding pocket; other site 768493012838 dimerization interface [polypeptide binding]; other site 768493012839 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 768493012840 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768493012841 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 768493012842 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 768493012843 Walker A/P-loop; other site 768493012844 ATP binding site [chemical binding]; other site 768493012845 Q-loop/lid; other site 768493012846 ABC transporter signature motif; other site 768493012847 Walker B; other site 768493012848 D-loop; other site 768493012849 H-loop/switch region; other site 768493012850 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 768493012851 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 768493012852 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 768493012853 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768493012854 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768493012855 Cytochrome c; Region: Cytochrom_C; pfam00034 768493012856 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 768493012857 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768493012858 Peptidase family M23; Region: Peptidase_M23; pfam01551 768493012859 acid-resistance membrane protein; Provisional; Region: PRK10209 768493012860 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 768493012861 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 768493012862 HSP70 interaction site [polypeptide binding]; other site 768493012863 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 768493012864 substrate binding site [polypeptide binding]; other site 768493012865 dimer interface [polypeptide binding]; other site 768493012866 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 768493012867 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 768493012868 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493012869 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493012870 LysR substrate binding domain; Region: LysR_substrate; pfam03466 768493012871 dimerization interface [polypeptide binding]; other site 768493012872 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 768493012873 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 768493012874 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 768493012875 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768493012876 DNA-binding site [nucleotide binding]; DNA binding site 768493012877 RNA-binding motif; other site 768493012878 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 768493012879 Excisionase-like protein; Region: Exc; pfam07825 768493012880 Excisionase-like protein; Region: Exc; pfam07825 768493012881 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 768493012882 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 768493012883 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 768493012884 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 768493012885 AntA/AntB antirepressor; Region: AntA; pfam08346 768493012886 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 768493012887 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 768493012888 integrase; Provisional; Region: PRK09692 768493012889 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 768493012890 active site 768493012891 Int/Topo IB signature motif; other site 768493012892 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 768493012893 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 768493012894 dimer interface [polypeptide binding]; other site 768493012895 putative anticodon binding site; other site 768493012896 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 768493012897 motif 1; other site 768493012898 active site 768493012899 motif 2; other site 768493012900 motif 3; other site 768493012901 peptide chain release factor 2; Validated; Region: prfB; PRK00578 768493012902 This domain is found in peptide chain release factors; Region: PCRF; smart00937 768493012903 RF-1 domain; Region: RF-1; pfam00472 768493012904 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 768493012905 DHH family; Region: DHH; pfam01368 768493012906 DHHA1 domain; Region: DHHA1; pfam02272 768493012907 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 768493012908 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 768493012909 dimerization domain [polypeptide binding]; other site 768493012910 dimer interface [polypeptide binding]; other site 768493012911 catalytic residues [active] 768493012912 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 768493012913 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 768493012914 active site 768493012915 Int/Topo IB signature motif; other site 768493012916 flavodoxin FldB; Provisional; Region: PRK12359 768493012917 Inner membrane protein CreD; Region: CreD; pfam06123 768493012918 sensory histidine kinase CreC; Provisional; Region: PRK11100 768493012919 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768493012920 dimerization interface [polypeptide binding]; other site 768493012921 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768493012922 dimer interface [polypeptide binding]; other site 768493012923 phosphorylation site [posttranslational modification] 768493012924 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493012925 ATP binding site [chemical binding]; other site 768493012926 Mg2+ binding site [ion binding]; other site 768493012927 G-X-G motif; other site 768493012928 DNA-binding response regulator CreB; Provisional; Region: PRK11083 768493012929 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493012930 active site 768493012931 phosphorylation site [posttranslational modification] 768493012932 intermolecular recognition site; other site 768493012933 dimerization interface [polypeptide binding]; other site 768493012934 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768493012935 DNA binding site [nucleotide binding] 768493012936 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 768493012937 hypothetical protein; Provisional; Region: PRK10878 768493012938 putative global regulator; Reviewed; Region: PRK09559 768493012939 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 768493012940 hemolysin; Provisional; Region: PRK15087 768493012941 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 768493012942 HD domain; Region: HD_3; pfam13023 768493012943 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493012944 metabolite-proton symporter; Region: 2A0106; TIGR00883 768493012945 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493012946 amidase; Provisional; Region: PRK07056 768493012947 Amidase; Region: Amidase; cl11426 768493012948 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 768493012949 Transcriptional regulators [Transcription]; Region: GntR; COG1802 768493012950 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768493012951 DNA-binding site [nucleotide binding]; DNA binding site 768493012952 FCD domain; Region: FCD; pfam07729 768493012953 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 768493012954 classical (c) SDRs; Region: SDR_c; cd05233 768493012955 NAD(P) binding site [chemical binding]; other site 768493012956 active site 768493012957 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 768493012958 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 768493012959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493012960 active site 768493012961 phosphorylation site [posttranslational modification] 768493012962 intermolecular recognition site; other site 768493012963 dimerization interface [polypeptide binding]; other site 768493012964 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768493012965 DNA binding site [nucleotide binding] 768493012966 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768493012967 dimer interface [polypeptide binding]; other site 768493012968 phosphorylation site [posttranslational modification] 768493012969 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493012970 ATP binding site [chemical binding]; other site 768493012971 Mg2+ binding site [ion binding]; other site 768493012972 G-X-G motif; other site 768493012973 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 768493012974 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 768493012975 NAD(P) binding site [chemical binding]; other site 768493012976 glycine dehydrogenase; Provisional; Region: PRK05367 768493012977 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 768493012978 tetramer interface [polypeptide binding]; other site 768493012979 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493012980 catalytic residue [active] 768493012981 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 768493012982 tetramer interface [polypeptide binding]; other site 768493012983 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493012984 catalytic residue [active] 768493012985 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 768493012986 lipoyl attachment site [posttranslational modification]; other site 768493012987 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 768493012988 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 768493012989 oxidoreductase; Provisional; Region: PRK08013 768493012990 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 768493012991 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 768493012992 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 768493012993 proline aminopeptidase P II; Provisional; Region: PRK10879 768493012994 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 768493012995 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 768493012996 active site 768493012997 hypothetical protein; Reviewed; Region: PRK01736 768493012998 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 768493012999 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 768493013000 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 768493013001 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 768493013002 ligand binding site [chemical binding]; other site 768493013003 NAD binding site [chemical binding]; other site 768493013004 tetramer interface [polypeptide binding]; other site 768493013005 catalytic site [active] 768493013006 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 768493013007 L-serine binding site [chemical binding]; other site 768493013008 ACT domain interface; other site 768493013009 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 768493013010 tetramer (dimer of dimers) interface [polypeptide binding]; other site 768493013011 active site 768493013012 dimer interface [polypeptide binding]; other site 768493013013 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 768493013014 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493013015 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 768493013016 putative dimerization interface [polypeptide binding]; other site 768493013017 oxidative stress defense protein; Provisional; Region: PRK11087 768493013018 Uncharacterized conserved protein [Function unknown]; Region: COG2968 768493013019 arginine exporter protein; Provisional; Region: PRK09304 768493013020 Transcriptional regulator [Transcription]; Region: IclR; COG1414 768493013021 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 768493013022 Bacterial transcriptional regulator; Region: IclR; pfam01614 768493013023 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 768493013024 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768493013025 Walker A/P-loop; other site 768493013026 ATP binding site [chemical binding]; other site 768493013027 Q-loop/lid; other site 768493013028 ABC transporter signature motif; other site 768493013029 Walker B; other site 768493013030 D-loop; other site 768493013031 H-loop/switch region; other site 768493013032 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768493013033 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768493013034 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768493013035 TM-ABC transporter signature motif; other site 768493013036 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_6; cd06315 768493013037 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 768493013038 putative ligand binding site [chemical binding]; other site 768493013039 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 768493013040 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 768493013041 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 768493013042 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493013043 D-galactonate transporter; Region: 2A0114; TIGR00893 768493013044 putative substrate translocation pore; other site 768493013045 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 768493013046 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 768493013047 putative N- and C-terminal domain interface [polypeptide binding]; other site 768493013048 putative active site [active] 768493013049 MgATP binding site [chemical binding]; other site 768493013050 catalytic site [active] 768493013051 metal binding site [ion binding]; metal-binding site 768493013052 putative xylulose binding site [chemical binding]; other site 768493013053 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 768493013054 active site 768493013055 dimer interface [polypeptide binding]; other site 768493013056 magnesium binding site [ion binding]; other site 768493013057 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 768493013058 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 768493013059 AP (apurinic/apyrimidinic) site pocket; other site 768493013060 DNA interaction; other site 768493013061 Metal-binding active site; metal-binding site 768493013062 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 768493013063 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 768493013064 intersubunit interface [polypeptide binding]; other site 768493013065 active site 768493013066 Zn2+ binding site [ion binding]; other site 768493013067 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 768493013068 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 768493013069 active site 768493013070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 768493013071 mechanosensitive channel MscS; Provisional; Region: PRK10334 768493013072 Mechanosensitive ion channel; Region: MS_channel; pfam00924 768493013073 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 768493013074 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 768493013075 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 768493013076 active site 768493013077 intersubunit interface [polypeptide binding]; other site 768493013078 zinc binding site [ion binding]; other site 768493013079 Na+ binding site [ion binding]; other site 768493013080 Phosphoglycerate kinase; Region: PGK; pfam00162 768493013081 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 768493013082 substrate binding site [chemical binding]; other site 768493013083 hinge regions; other site 768493013084 ADP binding site [chemical binding]; other site 768493013085 catalytic site [active] 768493013086 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 768493013087 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 768493013088 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 768493013089 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 768493013090 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768493013091 Walker A/P-loop; other site 768493013092 ATP binding site [chemical binding]; other site 768493013093 Q-loop/lid; other site 768493013094 ABC transporter signature motif; other site 768493013095 Walker B; other site 768493013096 D-loop; other site 768493013097 H-loop/switch region; other site 768493013098 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 768493013099 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493013100 dimer interface [polypeptide binding]; other site 768493013101 conserved gate region; other site 768493013102 ABC-ATPase subunit interface; other site 768493013103 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493013104 dimer interface [polypeptide binding]; other site 768493013105 conserved gate region; other site 768493013106 putative PBP binding loops; other site 768493013107 ABC-ATPase subunit interface; other site 768493013108 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 768493013109 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 768493013110 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768493013111 catalytic core [active] 768493013112 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 768493013113 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 768493013114 transmembrane helices; other site 768493013115 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493013116 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493013117 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 768493013118 putative dimerization interface [polypeptide binding]; other site 768493013119 transketolase; Reviewed; Region: PRK12753 768493013120 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 768493013121 TPP-binding site [chemical binding]; other site 768493013122 dimer interface [polypeptide binding]; other site 768493013123 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 768493013124 PYR/PP interface [polypeptide binding]; other site 768493013125 dimer interface [polypeptide binding]; other site 768493013126 TPP binding site [chemical binding]; other site 768493013127 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768493013128 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 768493013129 hypothetical protein; Provisional; Region: PRK07064 768493013130 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768493013131 PYR/PP interface [polypeptide binding]; other site 768493013132 dimer interface [polypeptide binding]; other site 768493013133 TPP binding site [chemical binding]; other site 768493013134 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768493013135 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 768493013136 TPP-binding site [chemical binding]; other site 768493013137 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 768493013138 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 768493013139 NAD(P) binding site [chemical binding]; other site 768493013140 catalytic residues [active] 768493013141 L-aspartate dehydrogenase; Provisional; Region: PRK13303 768493013142 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 768493013143 Domain of unknown function DUF108; Region: DUF108; pfam01958 768493013144 short chain dehydrogenase; Provisional; Region: PRK07062 768493013145 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768493013146 NAD(P) binding site [chemical binding]; other site 768493013147 active site 768493013148 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 768493013149 Cupin domain; Region: Cupin_2; pfam07883 768493013150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493013151 D-galactonate transporter; Region: 2A0114; TIGR00893 768493013152 putative substrate translocation pore; other site 768493013153 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 768493013154 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768493013155 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 768493013156 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768493013157 putative active site [active] 768493013158 putative metal binding site [ion binding]; other site 768493013159 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 768493013160 Transcriptional regulator [Transcription]; Region: IclR; COG1414 768493013161 Bacterial transcriptional regulator; Region: IclR; pfam01614 768493013162 short chain dehydrogenase; Provisional; Region: PRK12939 768493013163 classical (c) SDRs; Region: SDR_c; cd05233 768493013164 NAD(P) binding site [chemical binding]; other site 768493013165 active site 768493013166 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 768493013167 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 768493013168 [2Fe-2S] cluster binding site [ion binding]; other site 768493013169 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 768493013170 hydrophobic ligand binding site; other site 768493013171 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 768493013172 [2Fe-2S] cluster binding site [ion binding]; other site 768493013173 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 768493013174 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768493013175 RNA binding surface [nucleotide binding]; other site 768493013176 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 768493013177 probable active site [active] 768493013178 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 768493013179 agmatinase; Region: agmatinase; TIGR01230 768493013180 oligomer interface [polypeptide binding]; other site 768493013181 putative active site [active] 768493013182 Mn binding site [ion binding]; other site 768493013183 arginine decarboxylase; Provisional; Region: PRK05354 768493013184 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 768493013185 dimer interface [polypeptide binding]; other site 768493013186 active site 768493013187 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768493013188 catalytic residues [active] 768493013189 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 768493013190 S-adenosylmethionine synthetase; Validated; Region: PRK05250 768493013191 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 768493013192 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 768493013193 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 768493013194 Hok/gef family; Region: HOK_GEF; pfam01848 768493013195 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 768493013196 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768493013197 ABC-ATPase subunit interface; other site 768493013198 dimer interface [polypeptide binding]; other site 768493013199 putative PBP binding regions; other site 768493013200 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768493013201 ABC-ATPase subunit interface; other site 768493013202 dimer interface [polypeptide binding]; other site 768493013203 putative PBP binding regions; other site 768493013204 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 768493013205 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 768493013206 siderophore binding site; other site 768493013207 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 768493013208 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768493013209 Walker A/P-loop; other site 768493013210 ATP binding site [chemical binding]; other site 768493013211 Q-loop/lid; other site 768493013212 ABC transporter signature motif; other site 768493013213 Walker B; other site 768493013214 D-loop; other site 768493013215 H-loop/switch region; other site 768493013216 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 768493013217 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768493013218 N-terminal plug; other site 768493013219 ligand-binding site [chemical binding]; other site 768493013220 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 768493013221 Transglycosylase; Region: Transgly; pfam00912 768493013222 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 768493013223 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 768493013224 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768493013225 ATP binding site [chemical binding]; other site 768493013226 putative Mg++ binding site [ion binding]; other site 768493013227 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768493013228 nucleotide binding region [chemical binding]; other site 768493013229 ATP-binding site [chemical binding]; other site 768493013230 Helicase associated domain (HA2); Region: HA2; pfam04408 768493013231 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 768493013232 2'-5' RNA ligase; Provisional; Region: PRK15124 768493013233 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 768493013234 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 768493013235 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 768493013236 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 768493013237 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 768493013238 active site 768493013239 nucleotide binding site [chemical binding]; other site 768493013240 HIGH motif; other site 768493013241 KMSKS motif; other site 768493013242 poly(A) polymerase; Region: pcnB; TIGR01942 768493013243 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 768493013244 active site 768493013245 NTP binding site [chemical binding]; other site 768493013246 metal binding triad [ion binding]; metal-binding site 768493013247 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 768493013248 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 768493013249 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 768493013250 catalytic center binding site [active] 768493013251 ATP binding site [chemical binding]; other site 768493013252 sensor protein QseC; Provisional; Region: PRK10337 768493013253 HAMP domain; Region: HAMP; pfam00672 768493013254 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768493013255 dimer interface [polypeptide binding]; other site 768493013256 phosphorylation site [posttranslational modification] 768493013257 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493013258 ATP binding site [chemical binding]; other site 768493013259 Mg2+ binding site [ion binding]; other site 768493013260 G-X-G motif; other site 768493013261 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 768493013262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493013263 active site 768493013264 phosphorylation site [posttranslational modification] 768493013265 intermolecular recognition site; other site 768493013266 dimerization interface [polypeptide binding]; other site 768493013267 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768493013268 DNA binding site [nucleotide binding] 768493013269 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 768493013270 oligomerization interface [polypeptide binding]; other site 768493013271 active site 768493013272 metal binding site [ion binding]; metal-binding site 768493013273 Pantoate-beta-alanine ligase; Region: PanC; cd00560 768493013274 pantoate--beta-alanine ligase; Region: panC; TIGR00018 768493013275 active site 768493013276 ATP-binding site [chemical binding]; other site 768493013277 pantoate-binding site; other site 768493013278 HXXH motif; other site 768493013279 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 768493013280 tetramerization interface [polypeptide binding]; other site 768493013281 active site 768493013282 Bacterial SH3 domain; Region: SH3_3; cl17532 768493013283 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 768493013284 putative active site [active] 768493013285 putative metal binding site [ion binding]; other site 768493013286 inner membrane transport permease; Provisional; Region: PRK15066 768493013287 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 768493013288 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 768493013289 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 768493013290 Walker A/P-loop; other site 768493013291 ATP binding site [chemical binding]; other site 768493013292 Q-loop/lid; other site 768493013293 ABC transporter signature motif; other site 768493013294 Walker B; other site 768493013295 D-loop; other site 768493013296 H-loop/switch region; other site 768493013297 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 768493013298 active site clefts [active] 768493013299 zinc binding site [ion binding]; other site 768493013300 dimer interface [polypeptide binding]; other site 768493013301 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768493013302 active site 768493013303 multicopper oxidase; Provisional; Region: PRK10965 768493013304 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 768493013305 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 768493013306 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 768493013307 spermidine synthase; Provisional; Region: PRK00811 768493013308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493013309 S-adenosylmethionine binding site [chemical binding]; other site 768493013310 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 768493013311 hypothetical protein; Provisional; Region: PRK05248 768493013312 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 768493013313 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 768493013314 substrate binding site [chemical binding]; other site 768493013315 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 768493013316 substrate binding site [chemical binding]; other site 768493013317 ligand binding site [chemical binding]; other site 768493013318 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 768493013319 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768493013320 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768493013321 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768493013322 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 768493013323 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768493013324 E3 interaction surface; other site 768493013325 lipoyl attachment site [posttranslational modification]; other site 768493013326 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768493013327 E3 interaction surface; other site 768493013328 lipoyl attachment site [posttranslational modification]; other site 768493013329 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768493013330 E3 interaction surface; other site 768493013331 lipoyl attachment site [posttranslational modification]; other site 768493013332 e3 binding domain; Region: E3_binding; pfam02817 768493013333 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 768493013334 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 768493013335 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 768493013336 dimer interface [polypeptide binding]; other site 768493013337 TPP-binding site [chemical binding]; other site 768493013338 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 768493013339 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768493013340 DNA-binding site [nucleotide binding]; DNA binding site 768493013341 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 768493013342 aromatic amino acid transporter; Provisional; Region: PRK10238 768493013343 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 768493013344 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493013345 putative substrate translocation pore; other site 768493013346 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 768493013347 active site 768493013348 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768493013349 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768493013350 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 768493013351 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 768493013352 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 768493013353 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 768493013354 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 768493013355 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768493013356 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 768493013357 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768493013358 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 768493013359 Ligand binding site; other site 768493013360 metal-binding site 768493013361 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 768493013362 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 768493013363 XdhC Rossmann domain; Region: XdhC_C; pfam13478 768493013364 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 768493013365 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493013366 fumarate hydratase; Provisional; Region: PRK15389 768493013367 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 768493013368 Fumarase C-terminus; Region: Fumerase_C; pfam05683 768493013369 hypothetical protein; Provisional; Region: PRK04860 768493013370 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 768493013371 DNA-specific endonuclease I; Provisional; Region: PRK15137 768493013372 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 768493013373 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 768493013374 RNA methyltransferase, RsmE family; Region: TIGR00046 768493013375 glutathione synthetase; Provisional; Region: PRK05246 768493013376 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 768493013377 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 768493013378 hypothetical protein; Validated; Region: PRK00228 768493013379 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 768493013380 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 768493013381 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 768493013382 Walker A motif; other site 768493013383 ATP binding site [chemical binding]; other site 768493013384 Walker B motif; other site 768493013385 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 768493013386 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768493013387 catalytic residue [active] 768493013388 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 768493013389 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 768493013390 YGGT family; Region: YGGT; pfam02325 768493013391 YGGT family; Region: YGGT; pfam02325 768493013392 hypothetical protein; Validated; Region: PRK05090 768493013393 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 768493013394 active site 768493013395 dimerization interface [polypeptide binding]; other site 768493013396 HemN family oxidoreductase; Provisional; Region: PRK05660 768493013397 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768493013398 FeS/SAM binding site; other site 768493013399 HemN C-terminal domain; Region: HemN_C; pfam06969 768493013400 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 768493013401 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 768493013402 hypothetical protein; Provisional; Region: PRK10626 768493013403 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 768493013404 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 768493013405 glutaminase; Provisional; Region: PRK00971 768493013406 hypothetical protein; Provisional; Region: PRK11702 768493013407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493013408 S-adenosylmethionine binding site [chemical binding]; other site 768493013409 adenine DNA glycosylase; Provisional; Region: PRK10880 768493013410 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 768493013411 minor groove reading motif; other site 768493013412 helix-hairpin-helix signature motif; other site 768493013413 substrate binding pocket [chemical binding]; other site 768493013414 active site 768493013415 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 768493013416 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 768493013417 DNA binding and oxoG recognition site [nucleotide binding] 768493013418 oxidative damage protection protein; Provisional; Region: PRK05408 768493013419 murein transglycosylase C; Provisional; Region: mltC; PRK11671 768493013420 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 768493013421 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768493013422 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768493013423 catalytic residue [active] 768493013424 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 768493013425 2-methylcitrate dehydratase; Region: prpD; TIGR02330 768493013426 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 768493013427 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 768493013428 dimer interface [polypeptide binding]; other site 768493013429 active site 768493013430 citrylCoA binding site [chemical binding]; other site 768493013431 oxalacetate/citrate binding site [chemical binding]; other site 768493013432 coenzyme A binding site [chemical binding]; other site 768493013433 catalytic triad [active] 768493013434 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 768493013435 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 768493013436 tetramer interface [polypeptide binding]; other site 768493013437 active site 768493013438 Mg2+/Mn2+ binding site [ion binding]; other site 768493013439 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 768493013440 Propionate catabolism activator; Region: PrpR_N; pfam06506 768493013441 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768493013442 Walker A motif; other site 768493013443 ATP binding site [chemical binding]; other site 768493013444 Walker B motif; other site 768493013445 arginine finger; other site 768493013446 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768493013447 ornithine decarboxylase; Provisional; Region: PRK13578 768493013448 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 768493013449 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 768493013450 homodimer interface [polypeptide binding]; other site 768493013451 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493013452 catalytic residue [active] 768493013453 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 768493013454 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 768493013455 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 768493013456 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493013457 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493013458 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768493013459 dimerization interface [polypeptide binding]; other site 768493013460 Predicted transcriptional regulators [Transcription]; Region: COG1733 768493013461 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768493013462 dimerization interface [polypeptide binding]; other site 768493013463 putative DNA binding site [nucleotide binding]; other site 768493013464 putative Zn2+ binding site [ion binding]; other site 768493013465 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 768493013466 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 768493013467 classical (c) SDRs; Region: SDR_c; cd05233 768493013468 NAD(P) binding site [chemical binding]; other site 768493013469 active site 768493013470 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 768493013471 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 768493013472 Flavin Reductases; Region: FlaRed; cl00801 768493013473 This alignment model represents the N-terminal rieske domain of the oxygenase alpha subunit of aminopyrrolnitrin oxygenase (PrnD). PrnD is a novel Rieske N-oxygenase that catalyzes the final step in the pyrrolnitrin biosynthetic pathway, the oxidation...; Region: Rieske_RO_Alpha_PrnD; cd03537 768493013474 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 768493013475 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 768493013476 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 768493013477 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768493013478 Domain of unknown function (DUF1864); Region: DUF1864; pfam08933 768493013479 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 768493013480 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 768493013481 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 768493013482 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 768493013483 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 768493013484 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 768493013485 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 768493013486 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 768493013487 Walker A/P-loop; other site 768493013488 ATP binding site [chemical binding]; other site 768493013489 Q-loop/lid; other site 768493013490 ABC transporter signature motif; other site 768493013491 Walker B; other site 768493013492 D-loop; other site 768493013493 H-loop/switch region; other site 768493013494 Condensation domain; Region: Condensation; pfam00668 768493013495 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 768493013496 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 768493013497 active site 768493013498 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 768493013499 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 768493013500 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 768493013501 putative NADP binding site [chemical binding]; other site 768493013502 active site 768493013503 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768493013504 Condensation domain; Region: Condensation; pfam00668 768493013505 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 768493013506 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 768493013507 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 768493013508 acyl-activating enzyme (AAE) consensus motif; other site 768493013509 AMP binding site [chemical binding]; other site 768493013510 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768493013511 Condensation domain; Region: Condensation; pfam00668 768493013512 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 768493013513 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 768493013514 acyl-activating enzyme (AAE) consensus motif; other site 768493013515 AMP binding site [chemical binding]; other site 768493013516 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768493013517 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 768493013518 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 768493013519 acyl-activating enzyme (AAE) consensus motif; other site 768493013520 AMP binding site [chemical binding]; other site 768493013521 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768493013522 peptide synthase; Provisional; Region: PRK12467 768493013523 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 768493013524 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 768493013525 acyl-activating enzyme (AAE) consensus motif; other site 768493013526 AMP binding site [chemical binding]; other site 768493013527 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768493013528 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 768493013529 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 768493013530 acyl-activating enzyme (AAE) consensus motif; other site 768493013531 AMP binding site [chemical binding]; other site 768493013532 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768493013533 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 768493013534 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 768493013535 acyl-activating enzyme (AAE) consensus motif; other site 768493013536 AMP binding site [chemical binding]; other site 768493013537 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768493013538 C-N hydrolase family amidase; Provisional; Region: PRK10438 768493013539 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 768493013540 putative active site [active] 768493013541 catalytic triad [active] 768493013542 dimer interface [polypeptide binding]; other site 768493013543 multimer interface [polypeptide binding]; other site 768493013544 thioester reductase domain; Region: Thioester-redct; TIGR01746 768493013545 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 768493013546 putative NAD(P) binding site [chemical binding]; other site 768493013547 active site 768493013548 putative substrate binding site [chemical binding]; other site 768493013549 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 768493013550 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768493013551 NAD(P) binding site [chemical binding]; other site 768493013552 active site 768493013553 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 768493013554 FMN binding site [chemical binding]; other site 768493013555 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 768493013556 substrate binding site [chemical binding]; other site 768493013557 putative catalytic residue [active] 768493013558 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768493013559 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 768493013560 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768493013561 catalytic residue [active] 768493013562 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 768493013563 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 768493013564 active site 768493013565 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 768493013566 active site 768493013567 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 768493013568 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 768493013569 active site 2 [active] 768493013570 active site 1 [active] 768493013571 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 768493013572 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 768493013573 active site 768493013574 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 768493013575 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 768493013576 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 768493013577 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 768493013578 putative NADP binding site [chemical binding]; other site 768493013579 active site 768493013580 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 768493013581 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768493013582 FtsX-like permease family; Region: FtsX; pfam02687 768493013583 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768493013584 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768493013585 Walker A/P-loop; other site 768493013586 ATP binding site [chemical binding]; other site 768493013587 Q-loop/lid; other site 768493013588 ABC transporter signature motif; other site 768493013589 Walker B; other site 768493013590 D-loop; other site 768493013591 H-loop/switch region; other site 768493013592 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 768493013593 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 768493013594 HlyD family secretion protein; Region: HlyD_3; pfam13437 768493013595 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 768493013596 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 768493013597 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 768493013598 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 768493013599 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768493013600 catalytic residue [active] 768493013601 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 768493013602 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768493013603 PYR/PP interface [polypeptide binding]; other site 768493013604 dimer interface [polypeptide binding]; other site 768493013605 TPP binding site [chemical binding]; other site 768493013606 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768493013607 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 768493013608 TPP-binding site [chemical binding]; other site 768493013609 dimer interface [polypeptide binding]; other site 768493013610 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 768493013611 putative active site pocket [active] 768493013612 dimerization interface [polypeptide binding]; other site 768493013613 putative catalytic residue [active] 768493013614 Phosphopantetheine attachment site; Region: PP-binding; cl09936 768493013615 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 768493013616 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 768493013617 C-terminal domain interface [polypeptide binding]; other site 768493013618 GSH binding site (G-site) [chemical binding]; other site 768493013619 dimer interface [polypeptide binding]; other site 768493013620 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 768493013621 dimer interface [polypeptide binding]; other site 768493013622 N-terminal domain interface [polypeptide binding]; other site 768493013623 substrate binding pocket (H-site) [chemical binding]; other site 768493013624 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 768493013625 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 768493013626 homodimer interface [polypeptide binding]; other site 768493013627 substrate-cofactor binding pocket; other site 768493013628 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493013629 catalytic residue [active] 768493013630 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 768493013631 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 768493013632 active site pocket [active] 768493013633 Benzoate membrane transport protein; Region: BenE; pfam03594 768493013634 benzoate transporter; Region: benE; TIGR00843 768493013635 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 768493013636 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 768493013637 active site 768493013638 non-prolyl cis peptide bond; other site 768493013639 cystathionine beta-lyase; Provisional; Region: PRK05967 768493013640 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768493013641 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768493013642 catalytic residue [active] 768493013643 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 768493013644 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493013645 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493013646 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768493013647 dimerization interface [polypeptide binding]; other site 768493013648 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 768493013649 GAF domain; Region: GAF; cl17456 768493013650 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 768493013651 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768493013652 Walker A motif; other site 768493013653 ATP binding site [chemical binding]; other site 768493013654 Walker B motif; other site 768493013655 arginine finger; other site 768493013656 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 768493013657 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 768493013658 dimerization interface [polypeptide binding]; other site 768493013659 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 768493013660 ATP binding site [chemical binding]; other site 768493013661 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 768493013662 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 768493013663 HupF/HypC family; Region: HupF_HypC; cl00394 768493013664 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 768493013665 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 768493013666 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 768493013667 Transcriptional repressor of hyc and hyp operons; Region: HycA_repressor; cl08095 768493013668 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 768493013669 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 768493013670 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 768493013671 NADH dehydrogenase; Region: NADHdh; cl00469 768493013672 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 768493013673 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 768493013674 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 768493013675 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 768493013676 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768493013677 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 768493013678 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 768493013679 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 768493013680 nickel binding site [ion binding]; other site 768493013681 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 768493013682 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 768493013683 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 768493013684 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 768493013685 [4Fe-4S] binding site [ion binding]; other site 768493013686 molybdopterin cofactor binding site; other site 768493013687 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 768493013688 molybdopterin cofactor binding site; other site 768493013689 Acylphosphatase; Region: Acylphosphatase; pfam00708 768493013690 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 768493013691 HypF finger; Region: zf-HYPF; pfam07503 768493013692 HypF finger; Region: zf-HYPF; pfam07503 768493013693 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 768493013694 High-affinity nickel-transport protein; Region: NicO; cl00964 768493013695 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493013696 Coenzyme A binding pocket [chemical binding]; other site 768493013697 PAS fold; Region: PAS_4; pfam08448 768493013698 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768493013699 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768493013700 DNA binding residues [nucleotide binding] 768493013701 dimerization interface [polypeptide binding]; other site 768493013702 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 768493013703 Na binding site [ion binding]; other site 768493013704 NIPSNAP; Region: NIPSNAP; pfam07978 768493013705 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768493013706 non-specific DNA binding site [nucleotide binding]; other site 768493013707 salt bridge; other site 768493013708 sequence-specific DNA binding site [nucleotide binding]; other site 768493013709 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 768493013710 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 768493013711 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 768493013712 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 768493013713 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 768493013714 Phosphoesterase family; Region: Phosphoesterase; pfam04185 768493013715 Domain of unknown function (DUF756); Region: DUF756; pfam05506 768493013716 Domain of unknown function (DUF756); Region: DUF756; pfam05506 768493013717 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 768493013718 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768493013719 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768493013720 salt bridge; other site 768493013721 non-specific DNA binding site [nucleotide binding]; other site 768493013722 sequence-specific DNA binding site [nucleotide binding]; other site 768493013723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493013724 putative substrate translocation pore; other site 768493013725 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 768493013726 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 768493013727 Protein of unknown function, DUF596; Region: DUF596; cl10492 768493013728 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768493013729 anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154 768493013730 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 768493013731 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 768493013732 haemagglutination activity domain; Region: Haemagg_act; pfam05860 768493013733 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 768493013734 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768493013735 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768493013736 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768493013737 RTX toxin acyltransferase family; Region: HlyC; pfam02794 768493013738 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 768493013739 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 768493013740 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 768493013741 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768493013742 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 768493013743 putative substrate binding site [chemical binding]; other site 768493013744 putative ATP binding site [chemical binding]; other site 768493013745 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768493013746 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 768493013747 active site turn [active] 768493013748 phosphorylation site [posttranslational modification] 768493013749 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768493013750 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 768493013751 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 768493013752 substrate binding [chemical binding]; other site 768493013753 active site 768493013754 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 768493013755 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 768493013756 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768493013757 DNA binding site [nucleotide binding] 768493013758 domain linker motif; other site 768493013759 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 768493013760 dimerization interface [polypeptide binding]; other site 768493013761 ligand binding site [chemical binding]; other site 768493013762 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 768493013763 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 768493013764 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 768493013765 shikimate binding site; other site 768493013766 NAD(P) binding site [chemical binding]; other site 768493013767 biopolymer transport protein ExbD; Provisional; Region: PRK11267 768493013768 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 768493013769 biopolymer transport protein ExbB; Provisional; Region: PRK10414 768493013770 cystathionine beta-lyase; Provisional; Region: PRK08114 768493013771 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 768493013772 homodimer interface [polypeptide binding]; other site 768493013773 substrate-cofactor binding pocket; other site 768493013774 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493013775 catalytic residue [active] 768493013776 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 768493013777 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 768493013778 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493013779 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493013780 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 768493013781 putative effector binding pocket; other site 768493013782 putative dimerization interface [polypeptide binding]; other site 768493013783 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 768493013784 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 768493013785 putative NAD(P) binding site [chemical binding]; other site 768493013786 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 768493013787 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768493013788 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493013789 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493013790 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 768493013791 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 768493013792 dimer interface [polypeptide binding]; other site 768493013793 active site 768493013794 metal binding site [ion binding]; metal-binding site 768493013795 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768493013796 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768493013797 active site 768493013798 catalytic tetrad [active] 768493013799 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 768493013800 beta-galactosidase; Region: BGL; TIGR03356 768493013801 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 768493013802 methionine cluster; other site 768493013803 active site 768493013804 phosphorylation site [posttranslational modification] 768493013805 metal binding site [ion binding]; metal-binding site 768493013806 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 768493013807 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 768493013808 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 768493013809 active site 768493013810 P-loop; other site 768493013811 phosphorylation site [posttranslational modification] 768493013812 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 768493013813 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768493013814 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768493013815 catalytic residue [active] 768493013816 hypothetical protein; Provisional; Region: PRK01254 768493013817 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 768493013818 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 768493013819 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 768493013820 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768493013821 substrate binding site [chemical binding]; other site 768493013822 ATP binding site [chemical binding]; other site 768493013823 nucleoside transporter; Region: 2A0110; TIGR00889 768493013824 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493013825 purine nucleoside phosphorylase; Provisional; Region: PRK08202 768493013826 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 768493013827 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493013828 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 768493013829 putative dimerization interface [polypeptide binding]; other site 768493013830 putative substrate binding pocket [chemical binding]; other site 768493013831 FtsI repressor; Provisional; Region: PRK10883 768493013832 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 768493013833 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 768493013834 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 768493013835 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 768493013836 putative acyl-acceptor binding pocket; other site 768493013837 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 768493013838 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 768493013839 CAP-like domain; other site 768493013840 active site 768493013841 primary dimer interface [polypeptide binding]; other site 768493013842 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 768493013843 Uncharacterized conserved protein [Function unknown]; Region: COG1359 768493013844 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493013845 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493013846 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768493013847 dimerization interface [polypeptide binding]; other site 768493013848 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 768493013849 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493013850 ATP binding site [chemical binding]; other site 768493013851 Mg2+ binding site [ion binding]; other site 768493013852 G-X-G motif; other site 768493013853 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 768493013854 anchoring element; other site 768493013855 dimer interface [polypeptide binding]; other site 768493013856 ATP binding site [chemical binding]; other site 768493013857 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 768493013858 active site 768493013859 metal binding site [ion binding]; metal-binding site 768493013860 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 768493013861 esterase YqiA; Provisional; Region: PRK11071 768493013862 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768493013863 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 768493013864 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 768493013865 active site 768493013866 metal binding site [ion binding]; metal-binding site 768493013867 hexamer interface [polypeptide binding]; other site 768493013868 putative dehydrogenase; Provisional; Region: PRK11039 768493013869 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 768493013870 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 768493013871 dimer interface [polypeptide binding]; other site 768493013872 ADP-ribose binding site [chemical binding]; other site 768493013873 active site 768493013874 nudix motif; other site 768493013875 metal binding site [ion binding]; metal-binding site 768493013876 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 768493013877 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 768493013878 GAF domain; Region: GAF; pfam01590 768493013879 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 768493013880 putative active site [active] 768493013881 heme pocket [chemical binding]; other site 768493013882 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768493013883 Walker A motif; other site 768493013884 ATP binding site [chemical binding]; other site 768493013885 Walker B motif; other site 768493013886 arginine finger; other site 768493013887 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768493013888 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 768493013889 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 768493013890 active pocket/dimerization site; other site 768493013891 active site 768493013892 phosphorylation site [posttranslational modification] 768493013893 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 768493013894 dimerization domain swap beta strand [polypeptide binding]; other site 768493013895 regulatory protein interface [polypeptide binding]; other site 768493013896 active site 768493013897 regulatory phosphorylation site [posttranslational modification]; other site 768493013898 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 768493013899 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 768493013900 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 768493013901 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 768493013902 Dak1 domain; Region: Dak1; pfam02733 768493013903 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 768493013904 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 768493013905 dimer interface [polypeptide binding]; other site 768493013906 active site 768493013907 metal binding site [ion binding]; metal-binding site 768493013908 hypothetical protein; Provisional; Region: PRK11653 768493013909 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 768493013910 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 768493013911 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 768493013912 putative active site [active] 768493013913 metal binding site [ion binding]; metal-binding site 768493013914 zinc transporter ZupT; Provisional; Region: PRK04201 768493013915 ZIP Zinc transporter; Region: Zip; pfam02535 768493013916 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 768493013917 dimer interface [polypeptide binding]; other site 768493013918 Alkaline phosphatase homologues; Region: alkPPc; smart00098 768493013919 active site 768493013920 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 768493013921 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 768493013922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 768493013923 putative transporter; Provisional; Region: PRK11021 768493013924 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 768493013925 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 768493013926 putative ribose interaction site [chemical binding]; other site 768493013927 putative ADP binding site [chemical binding]; other site 768493013928 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 768493013929 active site 768493013930 nucleotide binding site [chemical binding]; other site 768493013931 HIGH motif; other site 768493013932 KMSKS motif; other site 768493013933 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 768493013934 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 768493013935 metal binding triad; other site 768493013936 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 768493013937 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 768493013938 metal binding triad; other site 768493013939 Uncharacterized conserved protein [Function unknown]; Region: COG3025 768493013940 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 768493013941 putative active site [active] 768493013942 putative metal binding residues [ion binding]; other site 768493013943 signature motif; other site 768493013944 putative triphosphate binding site [ion binding]; other site 768493013945 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 768493013946 SH3 domain-containing protein; Provisional; Region: PRK10884 768493013947 Bacterial SH3 domain homologues; Region: SH3b; smart00287 768493013948 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 768493013949 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 768493013950 active site 768493013951 NTP binding site [chemical binding]; other site 768493013952 metal binding triad [ion binding]; metal-binding site 768493013953 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 768493013954 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768493013955 Zn2+ binding site [ion binding]; other site 768493013956 Mg2+ binding site [ion binding]; other site 768493013957 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 768493013958 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 768493013959 homooctamer interface [polypeptide binding]; other site 768493013960 active site 768493013961 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 768493013962 UGMP family protein; Validated; Region: PRK09604 768493013963 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 768493013964 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 768493013965 DNA primase; Validated; Region: dnaG; PRK05667 768493013966 CHC2 zinc finger; Region: zf-CHC2; pfam01807 768493013967 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 768493013968 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 768493013969 active site 768493013970 metal binding site [ion binding]; metal-binding site 768493013971 interdomain interaction site; other site 768493013972 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 768493013973 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 768493013974 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 768493013975 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 768493013976 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 768493013977 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 768493013978 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768493013979 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 768493013980 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768493013981 DNA binding residues [nucleotide binding] 768493013982 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 768493013983 active site 768493013984 SUMO-1 interface [polypeptide binding]; other site 768493013985 HPP family; Region: HPP; pfam04982 768493013986 glutathione S-transferase; Provisional; Region: PRK15113 768493013987 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 768493013988 C-terminal domain interface [polypeptide binding]; other site 768493013989 GSH binding site (G-site) [chemical binding]; other site 768493013990 dimer interface [polypeptide binding]; other site 768493013991 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 768493013992 N-terminal domain interface [polypeptide binding]; other site 768493013993 putative dimer interface [polypeptide binding]; other site 768493013994 putative substrate binding pocket (H-site) [chemical binding]; other site 768493013995 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 768493013996 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 768493013997 succinic semialdehyde dehydrogenase; Region: PLN02278 768493013998 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 768493013999 tetramerization interface [polypeptide binding]; other site 768493014000 NAD(P) binding site [chemical binding]; other site 768493014001 catalytic residues [active] 768493014002 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 768493014003 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768493014004 inhibitor-cofactor binding pocket; inhibition site 768493014005 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493014006 catalytic residue [active] 768493014007 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768493014008 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768493014009 DNA-binding site [nucleotide binding]; DNA binding site 768493014010 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768493014011 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493014012 homodimer interface [polypeptide binding]; other site 768493014013 catalytic residue [active] 768493014014 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 768493014015 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768493014016 Walker A/P-loop; other site 768493014017 ATP binding site [chemical binding]; other site 768493014018 Q-loop/lid; other site 768493014019 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768493014020 ABC transporter signature motif; other site 768493014021 Walker B; other site 768493014022 D-loop; other site 768493014023 ABC transporter; Region: ABC_tran_2; pfam12848 768493014024 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768493014025 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 768493014026 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 768493014027 active site 768493014028 FMN binding site [chemical binding]; other site 768493014029 2,4-decadienoyl-CoA binding site; other site 768493014030 catalytic residue [active] 768493014031 4Fe-4S cluster binding site [ion binding]; other site 768493014032 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 768493014033 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768493014034 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 768493014035 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493014036 S-adenosylmethionine binding site [chemical binding]; other site 768493014037 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 768493014038 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768493014039 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768493014040 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 768493014041 catalytic triad [active] 768493014042 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 768493014043 serine/threonine transporter SstT; Provisional; Region: PRK13628 768493014044 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 768493014045 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 768493014046 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 768493014047 galactarate dehydratase; Region: galactar-dH20; TIGR03248 768493014048 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 768493014049 Glucuronate isomerase; Region: UxaC; pfam02614 768493014050 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 768493014051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493014052 D-galactonate transporter; Region: 2A0114; TIGR00893 768493014053 putative substrate translocation pore; other site 768493014054 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 768493014055 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768493014056 DNA-binding site [nucleotide binding]; DNA binding site 768493014057 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 768493014058 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 768493014059 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 768493014060 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 768493014061 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 768493014062 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 768493014063 Predicted membrane protein [Function unknown]; Region: COG5393 768493014064 YqjK-like protein; Region: YqjK; pfam13997 768493014065 Predicted membrane protein [Function unknown]; Region: COG2259 768493014066 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 768493014067 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 768493014068 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 768493014069 putative dimer interface [polypeptide binding]; other site 768493014070 N-terminal domain interface [polypeptide binding]; other site 768493014071 putative substrate binding pocket (H-site) [chemical binding]; other site 768493014072 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493014073 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 768493014074 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768493014075 dimerization interface [polypeptide binding]; other site 768493014076 Pirin-related protein [General function prediction only]; Region: COG1741 768493014077 Pirin; Region: Pirin; pfam02678 768493014078 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 768493014079 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 768493014080 putative SAM binding site [chemical binding]; other site 768493014081 putative homodimer interface [polypeptide binding]; other site 768493014082 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 768493014083 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 768493014084 putative ligand binding site [chemical binding]; other site 768493014085 hypothetical protein; Reviewed; Region: PRK12497 768493014086 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 768493014087 dimer interface [polypeptide binding]; other site 768493014088 active site 768493014089 outer membrane lipoprotein; Provisional; Region: PRK11023 768493014090 bacterial OsmY and nodulation domain; Region: BON; smart00749 768493014091 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 768493014092 Transglycosylase; Region: Transgly; cl17702 768493014093 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 768493014094 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 768493014095 conserved cys residue [active] 768493014096 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 768493014097 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768493014098 putative active site [active] 768493014099 heme pocket [chemical binding]; other site 768493014100 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768493014101 dimer interface [polypeptide binding]; other site 768493014102 phosphorylation site [posttranslational modification] 768493014103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493014104 ATP binding site [chemical binding]; other site 768493014105 Mg2+ binding site [ion binding]; other site 768493014106 G-X-G motif; other site 768493014107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493014108 active site 768493014109 phosphorylation site [posttranslational modification] 768493014110 intermolecular recognition site; other site 768493014111 dimerization interface [polypeptide binding]; other site 768493014112 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 768493014113 putative binding surface; other site 768493014114 active site 768493014115 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 768493014116 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768493014117 FeS/SAM binding site; other site 768493014118 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 768493014119 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 768493014120 active site 768493014121 dimer interface [polypeptide binding]; other site 768493014122 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 768493014123 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 768493014124 active site 768493014125 FMN binding site [chemical binding]; other site 768493014126 substrate binding site [chemical binding]; other site 768493014127 3Fe-4S cluster binding site [ion binding]; other site 768493014128 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 768493014129 domain interface; other site 768493014130 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 768493014131 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768493014132 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 768493014133 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768493014134 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 768493014135 stringent starvation protein A; Provisional; Region: sspA; PRK09481 768493014136 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 768493014137 C-terminal domain interface [polypeptide binding]; other site 768493014138 putative GSH binding site (G-site) [chemical binding]; other site 768493014139 dimer interface [polypeptide binding]; other site 768493014140 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 768493014141 dimer interface [polypeptide binding]; other site 768493014142 N-terminal domain interface [polypeptide binding]; other site 768493014143 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 768493014144 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 768493014145 23S rRNA interface [nucleotide binding]; other site 768493014146 L3 interface [polypeptide binding]; other site 768493014147 Predicted ATPase [General function prediction only]; Region: COG1485 768493014148 hypothetical protein; Provisional; Region: PRK11677 768493014149 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 768493014150 serine endoprotease; Provisional; Region: PRK10139 768493014151 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 768493014152 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 768493014153 protein binding site [polypeptide binding]; other site 768493014154 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 768493014155 serine endoprotease; Provisional; Region: PRK10898 768493014156 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 768493014157 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 768493014158 protein binding site [polypeptide binding]; other site 768493014159 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 768493014160 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 768493014161 hinge; other site 768493014162 active site 768493014163 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 768493014164 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 768493014165 anti sigma factor interaction site; other site 768493014166 regulatory phosphorylation site [posttranslational modification]; other site 768493014167 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 768493014168 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 768493014169 mce related protein; Region: MCE; pfam02470 768493014170 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 768493014171 conserved hypothetical integral membrane protein; Region: TIGR00056 768493014172 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 768493014173 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 768493014174 Walker A/P-loop; other site 768493014175 ATP binding site [chemical binding]; other site 768493014176 Q-loop/lid; other site 768493014177 ABC transporter signature motif; other site 768493014178 Walker B; other site 768493014179 D-loop; other site 768493014180 H-loop/switch region; other site 768493014181 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 768493014182 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 768493014183 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 768493014184 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 768493014185 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 768493014186 putative active site [active] 768493014187 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 768493014188 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 768493014189 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 768493014190 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 768493014191 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 768493014192 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 768493014193 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 768493014194 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 768493014195 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 768493014196 Walker A/P-loop; other site 768493014197 ATP binding site [chemical binding]; other site 768493014198 Q-loop/lid; other site 768493014199 ABC transporter signature motif; other site 768493014200 Walker B; other site 768493014201 D-loop; other site 768493014202 H-loop/switch region; other site 768493014203 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 768493014204 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 768493014205 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 768493014206 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 768493014207 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 768493014208 30S subunit binding site; other site 768493014209 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 768493014210 active site 768493014211 phosphorylation site [posttranslational modification] 768493014212 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 768493014213 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 768493014214 dimerization domain swap beta strand [polypeptide binding]; other site 768493014215 regulatory protein interface [polypeptide binding]; other site 768493014216 active site 768493014217 regulatory phosphorylation site [posttranslational modification]; other site 768493014218 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 768493014219 HTH domain; Region: HTH_11; pfam08279 768493014220 Mga helix-turn-helix domain; Region: Mga; pfam05043 768493014221 PRD domain; Region: PRD; pfam00874 768493014222 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 768493014223 active site 768493014224 P-loop; other site 768493014225 phosphorylation site [posttranslational modification] 768493014226 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 768493014227 active site 768493014228 phosphorylation site [posttranslational modification] 768493014229 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 768493014230 Protein of unknown function (DUF1341); Region: DUF1341; pfam07071 768493014231 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 768493014232 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768493014233 catalytic residue [active] 768493014234 dihydroorotase; Provisional; Region: PRK09237 768493014235 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 768493014236 active site 768493014237 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 768493014238 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 768493014239 Domain of unknown function (DUF4312); Region: DUF4312; pfam14189 768493014240 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272 768493014241 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 768493014242 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 768493014243 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 768493014244 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 768493014245 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 768493014246 active site 768493014247 cosubstrate binding site; other site 768493014248 substrate binding site [chemical binding]; other site 768493014249 catalytic site [active] 768493014250 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 768493014251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 768493014252 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768493014253 Helix-turn-helix domain; Region: HTH_18; pfam12833 768493014254 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493014255 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493014256 Cytochrome b562; Region: Cytochrom_B562; cl01546 768493014257 peptidase PmbA; Provisional; Region: PRK11040 768493014258 hypothetical protein; Provisional; Region: PRK05255 768493014259 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 768493014260 RNAase interaction site [polypeptide binding]; other site 768493014261 Barnase, a member of the family of homologous microbial ribonucleases, catalyses the cleavage of single-stranded RNA via a two-step mechanism thought to be similar to that of pancreatic ribonuclease. The mechanism involves a transesterification to give a...; Region: barnase; cd00933 768493014262 active site 768493014263 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 768493014264 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 768493014265 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 768493014266 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768493014267 HlyD family secretion protein; Region: HlyD_3; pfam13437 768493014268 efflux system membrane protein; Provisional; Region: PRK11594 768493014269 transcriptional regulator; Provisional; Region: PRK10632 768493014270 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493014271 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768493014272 putative effector binding pocket; other site 768493014273 dimerization interface [polypeptide binding]; other site 768493014274 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 768493014275 active site 768493014276 tetramer interface [polypeptide binding]; other site 768493014277 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 768493014278 haemagglutination activity domain; Region: Haemagg_act; pfam05860 768493014279 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768493014280 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768493014281 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768493014282 MafB19-like deaminase; Region: MafB19-deam; pfam14437 768493014283 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 768493014284 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 768493014285 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 768493014286 protease TldD; Provisional; Region: tldD; PRK10735 768493014287 nitrilase; Region: PLN02798 768493014288 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 768493014289 putative active site [active] 768493014290 catalytic triad [active] 768493014291 dimer interface [polypeptide binding]; other site 768493014292 hypothetical protein; Provisional; Region: PRK10899 768493014293 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 768493014294 ribonuclease G; Provisional; Region: PRK11712 768493014295 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 768493014296 homodimer interface [polypeptide binding]; other site 768493014297 oligonucleotide binding site [chemical binding]; other site 768493014298 Maf-like protein; Region: Maf; pfam02545 768493014299 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 768493014300 active site 768493014301 dimer interface [polypeptide binding]; other site 768493014302 rod shape-determining protein MreD; Provisional; Region: PRK11060 768493014303 rod shape-determining protein MreC; Region: mreC; TIGR00219 768493014304 rod shape-determining protein MreC; Region: MreC; pfam04085 768493014305 rod shape-determining protein MreB; Provisional; Region: PRK13927 768493014306 MreB and similar proteins; Region: MreB_like; cd10225 768493014307 nucleotide binding site [chemical binding]; other site 768493014308 Mg binding site [ion binding]; other site 768493014309 putative protofilament interaction site [polypeptide binding]; other site 768493014310 RodZ interaction site [polypeptide binding]; other site 768493014311 regulatory protein CsrD; Provisional; Region: PRK11059 768493014312 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768493014313 metal binding site [ion binding]; metal-binding site 768493014314 active site 768493014315 I-site; other site 768493014316 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768493014317 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 768493014318 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 768493014319 NADP binding site [chemical binding]; other site 768493014320 dimer interface [polypeptide binding]; other site 768493014321 TMAO/DMSO reductase; Reviewed; Region: PRK05363 768493014322 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 768493014323 Moco binding site; other site 768493014324 metal coordination site [ion binding]; other site 768493014325 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 768493014326 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 768493014327 Dehydroquinase class II; Region: DHquinase_II; pfam01220 768493014328 active site 768493014329 trimer interface [polypeptide binding]; other site 768493014330 dimer interface [polypeptide binding]; other site 768493014331 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 768493014332 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 768493014333 carboxyltransferase (CT) interaction site; other site 768493014334 biotinylation site [posttranslational modification]; other site 768493014335 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 768493014336 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 768493014337 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 768493014338 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 768493014339 hypothetical protein; Provisional; Region: PRK10633 768493014340 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 768493014341 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 768493014342 Na binding site [ion binding]; other site 768493014343 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 768493014344 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 768493014345 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 768493014346 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 768493014347 active site 768493014348 zinc binding site [ion binding]; other site 768493014349 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 768493014350 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 768493014351 FMN binding site [chemical binding]; other site 768493014352 active site 768493014353 catalytic residues [active] 768493014354 substrate binding site [chemical binding]; other site 768493014355 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 768493014356 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 768493014357 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 768493014358 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 768493014359 putative acyl-acceptor binding pocket; other site 768493014360 hypothetical protein; Validated; Region: PRK06186 768493014361 conserved cys residue [active] 768493014362 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 768493014363 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 768493014364 acyl-activating enzyme (AAE) consensus motif; other site 768493014365 AMP binding site [chemical binding]; other site 768493014366 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768493014367 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 768493014368 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 768493014369 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493014370 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493014371 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 768493014372 putative dimerization interface [polypeptide binding]; other site 768493014373 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 768493014374 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 768493014375 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 768493014376 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768493014377 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 768493014378 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 768493014379 putative C-terminal domain interface [polypeptide binding]; other site 768493014380 putative GSH binding site (G-site) [chemical binding]; other site 768493014381 putative dimer interface [polypeptide binding]; other site 768493014382 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 768493014383 putative N-terminal domain interface [polypeptide binding]; other site 768493014384 putative dimer interface [polypeptide binding]; other site 768493014385 putative substrate binding pocket (H-site) [chemical binding]; other site 768493014386 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 768493014387 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493014388 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493014389 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768493014390 putative effector binding pocket; other site 768493014391 dimerization interface [polypeptide binding]; other site 768493014392 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 768493014393 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768493014394 NAD(P) binding site [chemical binding]; other site 768493014395 active site 768493014396 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 768493014397 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 768493014398 dimer interface [polypeptide binding]; other site 768493014399 ssDNA binding site [nucleotide binding]; other site 768493014400 tetramer (dimer of dimers) interface [polypeptide binding]; other site 768493014401 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 768493014402 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 768493014403 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 768493014404 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 768493014405 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 768493014406 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 768493014407 putative NAD(P) binding site [chemical binding]; other site 768493014408 putative substrate binding site [chemical binding]; other site 768493014409 catalytic Zn binding site [ion binding]; other site 768493014410 structural Zn binding site [ion binding]; other site 768493014411 dimer interface [polypeptide binding]; other site 768493014412 maltose O-acetyltransferase; Provisional; Region: PRK10092 768493014413 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 768493014414 active site 768493014415 substrate binding site [chemical binding]; other site 768493014416 trimer interface [polypeptide binding]; other site 768493014417 CoA binding site [chemical binding]; other site 768493014418 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 768493014419 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 768493014420 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 768493014421 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768493014422 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493014423 homodimer interface [polypeptide binding]; other site 768493014424 catalytic residue [active] 768493014425 Uncharacterized conserved protein [Function unknown]; Region: COG1284 768493014426 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 768493014427 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768493014428 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 768493014429 putative DNA binding site [nucleotide binding]; other site 768493014430 putative Zn2+ binding site [ion binding]; other site 768493014431 AsnC family; Region: AsnC_trans_reg; pfam01037 768493014432 aromatic amino acid transporter; Provisional; Region: PRK10238 768493014433 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768493014434 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768493014435 substrate binding pocket [chemical binding]; other site 768493014436 membrane-bound complex binding site; other site 768493014437 hinge residues; other site 768493014438 alanine racemase; Reviewed; Region: alr; PRK00053 768493014439 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 768493014440 active site 768493014441 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768493014442 substrate binding site [chemical binding]; other site 768493014443 catalytic residues [active] 768493014444 dimer interface [polypeptide binding]; other site 768493014445 replicative DNA helicase; Provisional; Region: PRK08006 768493014446 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 768493014447 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 768493014448 Walker A motif; other site 768493014449 ATP binding site [chemical binding]; other site 768493014450 Walker B motif; other site 768493014451 DNA binding loops [nucleotide binding] 768493014452 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 768493014453 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 768493014454 NADP binding site [chemical binding]; other site 768493014455 dimer interface [polypeptide binding]; other site 768493014456 phage shock protein G; Reviewed; Region: pspG; PRK09459 768493014457 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 768493014458 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 768493014459 FMN binding site [chemical binding]; other site 768493014460 active site 768493014461 catalytic residues [active] 768493014462 substrate binding site [chemical binding]; other site 768493014463 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768493014464 binding surface 768493014465 TPR motif; other site 768493014466 Tetratricopeptide repeat; Region: TPR_16; pfam13432 768493014467 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 768493014468 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768493014469 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768493014470 DNA binding residues [nucleotide binding] 768493014471 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 768493014472 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 768493014473 metal binding site 2 [ion binding]; metal-binding site 768493014474 putative DNA binding helix; other site 768493014475 metal binding site 1 [ion binding]; metal-binding site 768493014476 dimer interface [polypeptide binding]; other site 768493014477 structural Zn2+ binding site [ion binding]; other site 768493014478 hypothetical protein; Provisional; Region: PRK10428 768493014479 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 768493014480 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 768493014481 LexA repressor; Validated; Region: PRK00215 768493014482 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 768493014483 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 768493014484 Catalytic site [active] 768493014485 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 768493014486 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 768493014487 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 768493014488 putative acyl-acceptor binding pocket; other site 768493014489 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 768493014490 UbiA prenyltransferase family; Region: UbiA; pfam01040 768493014491 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 768493014492 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 768493014493 active site 768493014494 maltose regulon periplasmic protein; Provisional; Region: PRK10564 768493014495 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 768493014496 trimer interface; other site 768493014497 sugar binding site [chemical binding]; other site 768493014498 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 768493014499 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 768493014500 Walker A/P-loop; other site 768493014501 ATP binding site [chemical binding]; other site 768493014502 Q-loop/lid; other site 768493014503 ABC transporter signature motif; other site 768493014504 Walker B; other site 768493014505 D-loop; other site 768493014506 H-loop/switch region; other site 768493014507 TOBE domain; Region: TOBE_2; pfam08402 768493014508 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 768493014509 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 768493014510 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 768493014511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493014512 dimer interface [polypeptide binding]; other site 768493014513 conserved gate region; other site 768493014514 putative PBP binding loops; other site 768493014515 ABC-ATPase subunit interface; other site 768493014516 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 768493014517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493014518 dimer interface [polypeptide binding]; other site 768493014519 conserved gate region; other site 768493014520 putative PBP binding loops; other site 768493014521 ABC-ATPase subunit interface; other site 768493014522 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 768493014523 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 768493014524 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 768493014525 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 768493014526 active site 768493014527 dimer interface [polypeptide binding]; other site 768493014528 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 768493014529 dimer interface [polypeptide binding]; other site 768493014530 active site 768493014531 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 768493014532 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 768493014533 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 768493014534 TrkA-N domain; Region: TrkA_N; pfam02254 768493014535 aspartate kinase III; Validated; Region: PRK09084 768493014536 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 768493014537 nucleotide binding site [chemical binding]; other site 768493014538 substrate binding site [chemical binding]; other site 768493014539 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 768493014540 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 768493014541 dimer interface [polypeptide binding]; other site 768493014542 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 768493014543 Sodium Bile acid symporter family; Region: SBF; pfam01758 768493014544 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 768493014545 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 768493014546 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 768493014547 haemagglutination activity domain; Region: Haemagg_act; pfam05860 768493014548 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768493014549 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768493014550 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768493014551 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768493014552 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768493014553 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 768493014554 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 768493014555 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 768493014556 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768493014557 Walker A/P-loop; other site 768493014558 ATP binding site [chemical binding]; other site 768493014559 Q-loop/lid; other site 768493014560 ABC transporter signature motif; other site 768493014561 Walker B; other site 768493014562 D-loop; other site 768493014563 H-loop/switch region; other site 768493014564 TOBE domain; Region: TOBE_2; pfam08402 768493014565 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 768493014566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493014567 dimer interface [polypeptide binding]; other site 768493014568 conserved gate region; other site 768493014569 putative PBP binding loops; other site 768493014570 ABC-ATPase subunit interface; other site 768493014571 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 768493014572 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493014573 putative PBP binding loops; other site 768493014574 ABC-ATPase subunit interface; other site 768493014575 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 768493014576 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 768493014577 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 768493014578 transcriptional regulator protein; Region: phnR; TIGR03337 768493014579 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768493014580 DNA-binding site [nucleotide binding]; DNA binding site 768493014581 UTRA domain; Region: UTRA; pfam07702 768493014582 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 768493014583 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 768493014584 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 768493014585 substrate binding pocket [chemical binding]; other site 768493014586 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 768493014587 B12 binding site [chemical binding]; other site 768493014588 cobalt ligand [ion binding]; other site 768493014589 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 768493014590 transcriptional repressor IclR; Provisional; Region: PRK11569 768493014591 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 768493014592 Bacterial transcriptional regulator; Region: IclR; pfam01614 768493014593 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 768493014594 ATP-binding site [chemical binding]; other site 768493014595 Gluconate-6-phosphate binding site [chemical binding]; other site 768493014596 low affinity gluconate transporter; Provisional; Region: PRK10472 768493014597 GntP family permease; Region: GntP_permease; pfam02447 768493014598 phosphogluconate dehydratase; Validated; Region: PRK09054 768493014599 6-phosphogluconate dehydratase; Region: edd; TIGR01196 768493014600 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 768493014601 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 768493014602 active site 768493014603 intersubunit interface [polypeptide binding]; other site 768493014604 catalytic residue [active] 768493014605 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 768493014606 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 768493014607 isocitrate lyase; Provisional; Region: PRK15063 768493014608 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 768493014609 tetramer interface [polypeptide binding]; other site 768493014610 active site 768493014611 Mg2+/Mn2+ binding site [ion binding]; other site 768493014612 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 768493014613 malate synthase A; Region: malate_syn_A; TIGR01344 768493014614 active site 768493014615 homoserine O-succinyltransferase; Provisional; Region: PRK05368 768493014616 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 768493014617 proposed active site lysine [active] 768493014618 conserved cys residue [active] 768493014619 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 768493014620 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 768493014621 trimer interface [polypeptide binding]; other site 768493014622 putative metal binding site [ion binding]; other site 768493014623 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 768493014624 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 768493014625 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 768493014626 shikimate binding site; other site 768493014627 NAD(P) binding site [chemical binding]; other site 768493014628 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 768493014629 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 768493014630 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 768493014631 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 768493014632 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 768493014633 hypothetical protein; Validated; Region: PRK03430 768493014634 hypothetical protein; Provisional; Region: PRK10736 768493014635 DNA protecting protein DprA; Region: dprA; TIGR00732 768493014636 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 768493014637 active site 768493014638 catalytic residues [active] 768493014639 metal binding site [ion binding]; metal-binding site 768493014640 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 768493014641 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 768493014642 putative active site [active] 768493014643 substrate binding site [chemical binding]; other site 768493014644 putative cosubstrate binding site; other site 768493014645 catalytic site [active] 768493014646 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 768493014647 substrate binding site [chemical binding]; other site 768493014648 16S rRNA methyltransferase B; Provisional; Region: PRK10901 768493014649 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 768493014650 putative RNA binding site [nucleotide binding]; other site 768493014651 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493014652 S-adenosylmethionine binding site [chemical binding]; other site 768493014653 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 768493014654 TrkA-N domain; Region: TrkA_N; pfam02254 768493014655 TrkA-C domain; Region: TrkA_C; pfam02080 768493014656 TrkA-N domain; Region: TrkA_N; pfam02254 768493014657 TrkA-C domain; Region: TrkA_C; pfam02080 768493014658 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 768493014659 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 768493014660 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 768493014661 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 768493014662 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 768493014663 DNA binding residues [nucleotide binding] 768493014664 dimer interface [polypeptide binding]; other site 768493014665 metal binding site [ion binding]; metal-binding site 768493014666 hypothetical protein; Provisional; Region: PRK10203 768493014667 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 768493014668 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 768493014669 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 768493014670 alphaNTD homodimer interface [polypeptide binding]; other site 768493014671 alphaNTD - beta interaction site [polypeptide binding]; other site 768493014672 alphaNTD - beta' interaction site [polypeptide binding]; other site 768493014673 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 768493014674 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 768493014675 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 768493014676 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768493014677 RNA binding surface [nucleotide binding]; other site 768493014678 30S ribosomal protein S11; Validated; Region: PRK05309 768493014679 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 768493014680 30S ribosomal protein S13; Region: bact_S13; TIGR03631 768493014681 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 768493014682 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 768493014683 SecY translocase; Region: SecY; pfam00344 768493014684 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 768493014685 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 768493014686 23S rRNA binding site [nucleotide binding]; other site 768493014687 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 768493014688 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 768493014689 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 768493014690 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 768493014691 5S rRNA interface [nucleotide binding]; other site 768493014692 23S rRNA interface [nucleotide binding]; other site 768493014693 L5 interface [polypeptide binding]; other site 768493014694 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 768493014695 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 768493014696 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 768493014697 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 768493014698 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 768493014699 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 768493014700 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 768493014701 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 768493014702 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 768493014703 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 768493014704 RNA binding site [nucleotide binding]; other site 768493014705 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 768493014706 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 768493014707 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 768493014708 23S rRNA interface [nucleotide binding]; other site 768493014709 putative translocon interaction site; other site 768493014710 signal recognition particle (SRP54) interaction site; other site 768493014711 L23 interface [polypeptide binding]; other site 768493014712 trigger factor interaction site; other site 768493014713 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 768493014714 23S rRNA interface [nucleotide binding]; other site 768493014715 5S rRNA interface [nucleotide binding]; other site 768493014716 putative antibiotic binding site [chemical binding]; other site 768493014717 L25 interface [polypeptide binding]; other site 768493014718 L27 interface [polypeptide binding]; other site 768493014719 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 768493014720 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 768493014721 G-X-X-G motif; other site 768493014722 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 768493014723 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 768493014724 protein-rRNA interface [nucleotide binding]; other site 768493014725 putative translocon binding site; other site 768493014726 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 768493014727 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 768493014728 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 768493014729 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 768493014730 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 768493014731 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 768493014732 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 768493014733 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 768493014734 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 768493014735 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 768493014736 heme binding site [chemical binding]; other site 768493014737 ferroxidase pore; other site 768493014738 ferroxidase diiron center [ion binding]; other site 768493014739 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 768493014740 elongation factor Tu; Reviewed; Region: PRK00049 768493014741 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 768493014742 G1 box; other site 768493014743 GEF interaction site [polypeptide binding]; other site 768493014744 GTP/Mg2+ binding site [chemical binding]; other site 768493014745 Switch I region; other site 768493014746 G2 box; other site 768493014747 G3 box; other site 768493014748 Switch II region; other site 768493014749 G4 box; other site 768493014750 G5 box; other site 768493014751 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 768493014752 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 768493014753 Antibiotic Binding Site [chemical binding]; other site 768493014754 elongation factor G; Reviewed; Region: PRK00007 768493014755 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 768493014756 G1 box; other site 768493014757 putative GEF interaction site [polypeptide binding]; other site 768493014758 GTP/Mg2+ binding site [chemical binding]; other site 768493014759 Switch I region; other site 768493014760 G2 box; other site 768493014761 G3 box; other site 768493014762 Switch II region; other site 768493014763 G4 box; other site 768493014764 G5 box; other site 768493014765 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 768493014766 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 768493014767 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 768493014768 30S ribosomal protein S7; Validated; Region: PRK05302 768493014769 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 768493014770 S17 interaction site [polypeptide binding]; other site 768493014771 S8 interaction site; other site 768493014772 16S rRNA interaction site [nucleotide binding]; other site 768493014773 streptomycin interaction site [chemical binding]; other site 768493014774 23S rRNA interaction site [nucleotide binding]; other site 768493014775 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 768493014776 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 768493014777 sulfur relay protein TusC; Validated; Region: PRK00211 768493014778 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 768493014779 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 768493014780 YheO-like PAS domain; Region: PAS_6; pfam08348 768493014781 HTH domain; Region: HTH_22; pfam13309 768493014782 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 768493014783 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 768493014784 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 768493014785 phi X174 lysis protein; Provisional; Region: PRK02793 768493014786 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737 768493014787 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 768493014788 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 768493014789 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 768493014790 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 768493014791 TrkA-N domain; Region: TrkA_N; pfam02254 768493014792 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 768493014793 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 768493014794 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768493014795 Walker A/P-loop; other site 768493014796 ATP binding site [chemical binding]; other site 768493014797 Q-loop/lid; other site 768493014798 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768493014799 ABC transporter; Region: ABC_tran_2; pfam12848 768493014800 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768493014801 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 768493014802 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 768493014803 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 768493014804 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493014805 dimer interface [polypeptide binding]; other site 768493014806 conserved gate region; other site 768493014807 putative PBP binding loops; other site 768493014808 ABC-ATPase subunit interface; other site 768493014809 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 768493014810 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 768493014811 Walker A/P-loop; other site 768493014812 ATP binding site [chemical binding]; other site 768493014813 Q-loop/lid; other site 768493014814 ABC transporter signature motif; other site 768493014815 Walker B; other site 768493014816 D-loop; other site 768493014817 H-loop/switch region; other site 768493014818 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 768493014819 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768493014820 substrate binding pocket [chemical binding]; other site 768493014821 membrane-bound complex binding site; other site 768493014822 hinge residues; other site 768493014823 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 768493014824 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 768493014825 putative hydrolase; Provisional; Region: PRK10985 768493014826 hypothetical protein; Provisional; Region: PRK04966 768493014827 phosphoribulokinase; Provisional; Region: PRK15453 768493014828 hypothetical protein; Provisional; Region: PRK10738 768493014829 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 768493014830 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 768493014831 ligand binding site [chemical binding]; other site 768493014832 flexible hinge region; other site 768493014833 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 768493014834 putative switch regulator; other site 768493014835 non-specific DNA interactions [nucleotide binding]; other site 768493014836 DNA binding site [nucleotide binding] 768493014837 sequence specific DNA binding site [nucleotide binding]; other site 768493014838 putative cAMP binding site [chemical binding]; other site 768493014839 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 768493014840 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 768493014841 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 768493014842 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 768493014843 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768493014844 inhibitor-cofactor binding pocket; inhibition site 768493014845 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493014846 catalytic residue [active] 768493014847 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 768493014848 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 768493014849 glutamine binding [chemical binding]; other site 768493014850 catalytic triad [active] 768493014851 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 768493014852 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 768493014853 Walker A motif; other site 768493014854 ATP binding site [chemical binding]; other site 768493014855 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 768493014856 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 768493014857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493014858 active site 768493014859 phosphorylation site [posttranslational modification] 768493014860 intermolecular recognition site; other site 768493014861 dimerization interface [polypeptide binding]; other site 768493014862 LytTr DNA-binding domain; Region: LytTR; pfam04397 768493014863 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 768493014864 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 768493014865 GAF domain; Region: GAF; pfam01590 768493014866 Histidine kinase; Region: His_kinase; pfam06580 768493014867 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493014868 ATP binding site [chemical binding]; other site 768493014869 Mg2+ binding site [ion binding]; other site 768493014870 G-X-G motif; other site 768493014871 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 768493014872 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 768493014873 active site 768493014874 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 768493014875 active site 768493014876 methionine cluster; other site 768493014877 phosphorylation site [posttranslational modification] 768493014878 metal binding site [ion binding]; metal-binding site 768493014879 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 768493014880 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 768493014881 NAD binding site [chemical binding]; other site 768493014882 sugar binding site [chemical binding]; other site 768493014883 divalent metal binding site [ion binding]; other site 768493014884 tetramer (dimer of dimers) interface [polypeptide binding]; other site 768493014885 dimer interface [polypeptide binding]; other site 768493014886 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768493014887 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768493014888 DNA binding site [nucleotide binding] 768493014889 domain linker motif; other site 768493014890 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 768493014891 dimerization interface (closed form) [polypeptide binding]; other site 768493014892 ligand binding site [chemical binding]; other site 768493014893 putative transporter; Provisional; Region: PRK03699 768493014894 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493014895 putative substrate translocation pore; other site 768493014896 cytosine deaminase; Provisional; Region: PRK09230 768493014897 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 768493014898 active site 768493014899 nitrite reductase subunit NirD; Provisional; Region: PRK14989 768493014900 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768493014901 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 768493014902 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 768493014903 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 768493014904 nitrite transporter NirC; Provisional; Region: PRK11562 768493014905 siroheme synthase; Provisional; Region: cysG; PRK10637 768493014906 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 768493014907 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 768493014908 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 768493014909 active site 768493014910 SAM binding site [chemical binding]; other site 768493014911 homodimer interface [polypeptide binding]; other site 768493014912 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 768493014913 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 768493014914 active site 768493014915 HIGH motif; other site 768493014916 dimer interface [polypeptide binding]; other site 768493014917 KMSKS motif; other site 768493014918 phosphoglycolate phosphatase; Provisional; Region: PRK13222 768493014919 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 768493014920 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768493014921 motif II; other site 768493014922 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 768493014923 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 768493014924 substrate binding site [chemical binding]; other site 768493014925 hexamer interface [polypeptide binding]; other site 768493014926 metal binding site [ion binding]; metal-binding site 768493014927 DNA adenine methylase; Provisional; Region: PRK10904 768493014928 hypothetical protein; Reviewed; Region: PRK11901 768493014929 cell division protein DamX; Validated; Region: PRK10905 768493014930 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 768493014931 active site 768493014932 dimer interface [polypeptide binding]; other site 768493014933 metal binding site [ion binding]; metal-binding site 768493014934 shikimate kinase; Reviewed; Region: aroK; PRK00131 768493014935 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 768493014936 ADP binding site [chemical binding]; other site 768493014937 magnesium binding site [ion binding]; other site 768493014938 putative shikimate binding site; other site 768493014939 putative outer membrane porin HofQ; Provisional; Region: hofQ; PRK13568 768493014940 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 768493014941 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 768493014942 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 768493014943 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 768493014944 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 768493014945 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 768493014946 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 768493014947 Transglycosylase; Region: Transgly; pfam00912 768493014948 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 768493014949 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 768493014950 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 768493014951 ADP-ribose binding site [chemical binding]; other site 768493014952 dimer interface [polypeptide binding]; other site 768493014953 active site 768493014954 nudix motif; other site 768493014955 metal binding site [ion binding]; metal-binding site 768493014956 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 768493014957 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 768493014958 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768493014959 motif II; other site 768493014960 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768493014961 RNA binding surface [nucleotide binding]; other site 768493014962 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 768493014963 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 768493014964 dimerization interface [polypeptide binding]; other site 768493014965 domain crossover interface; other site 768493014966 redox-dependent activation switch; other site 768493014967 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 768493014968 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 768493014969 active site 768493014970 substrate-binding site [chemical binding]; other site 768493014971 metal-binding site [ion binding] 768493014972 ATP binding site [chemical binding]; other site 768493014973 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 768493014974 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 768493014975 oligomeric interface; other site 768493014976 putative active site [active] 768493014977 homodimer interface [polypeptide binding]; other site 768493014978 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 768493014979 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768493014980 dimerization interface [polypeptide binding]; other site 768493014981 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768493014982 dimer interface [polypeptide binding]; other site 768493014983 phosphorylation site [posttranslational modification] 768493014984 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493014985 ATP binding site [chemical binding]; other site 768493014986 G-X-G motif; other site 768493014987 osmolarity response regulator; Provisional; Region: ompR; PRK09468 768493014988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493014989 active site 768493014990 phosphorylation site [posttranslational modification] 768493014991 intermolecular recognition site; other site 768493014992 dimerization interface [polypeptide binding]; other site 768493014993 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768493014994 DNA binding site [nucleotide binding] 768493014995 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 768493014996 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 768493014997 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 768493014998 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 768493014999 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 768493015000 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 768493015001 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 768493015002 RNA binding site [nucleotide binding]; other site 768493015003 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 768493015004 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 768493015005 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 768493015006 G1 box; other site 768493015007 GTP/Mg2+ binding site [chemical binding]; other site 768493015008 Switch I region; other site 768493015009 G2 box; other site 768493015010 G3 box; other site 768493015011 Switch II region; other site 768493015012 G4 box; other site 768493015013 G5 box; other site 768493015014 Nucleoside recognition; Region: Gate; pfam07670 768493015015 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 768493015016 Nucleoside recognition; Region: Gate; pfam07670 768493015017 FeoC like transcriptional regulator; Region: FeoC; cl17677 768493015018 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 768493015019 carboxylesterase BioH; Provisional; Region: PRK10349 768493015020 DNA utilization protein GntX; Provisional; Region: PRK11595 768493015021 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768493015022 active site 768493015023 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 768493015024 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 768493015025 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 768493015026 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 768493015027 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 768493015028 maltodextrin phosphorylase; Provisional; Region: PRK14985 768493015029 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 768493015030 active site pocket [active] 768493015031 transcriptional regulator MalT; Provisional; Region: PRK04841 768493015032 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768493015033 DNA binding residues [nucleotide binding] 768493015034 dimerization interface [polypeptide binding]; other site 768493015035 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 768493015036 active site residue [active] 768493015037 D-galactonate transporter; Region: 2A0114; TIGR00893 768493015038 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493015039 putative substrate translocation pore; other site 768493015040 Domain of unknown function (DUF386); Region: DUF386; cl01047 768493015041 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 768493015042 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 768493015043 inhibitor site; inhibition site 768493015044 active site 768493015045 dimer interface [polypeptide binding]; other site 768493015046 catalytic residue [active] 768493015047 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 768493015048 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 768493015049 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 768493015050 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768493015051 substrate binding site [chemical binding]; other site 768493015052 dimer interface [polypeptide binding]; other site 768493015053 ATP binding site [chemical binding]; other site 768493015054 intramembrane serine protease GlpG; Provisional; Region: PRK10907 768493015055 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 768493015056 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 768493015057 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 768493015058 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 768493015059 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 768493015060 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 768493015061 glycogen phosphorylase; Provisional; Region: PRK14986 768493015062 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 768493015063 homodimer interface [polypeptide binding]; other site 768493015064 active site pocket [active] 768493015065 glycogen synthase; Provisional; Region: glgA; PRK00654 768493015066 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 768493015067 ADP-binding pocket [chemical binding]; other site 768493015068 homodimer interface [polypeptide binding]; other site 768493015069 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 768493015070 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 768493015071 ligand binding site; other site 768493015072 oligomer interface; other site 768493015073 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 768493015074 sulfate 1 binding site; other site 768493015075 glycogen debranching enzyme; Provisional; Region: PRK03705 768493015076 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 768493015077 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 768493015078 active site 768493015079 catalytic site [active] 768493015080 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 768493015081 glycogen branching enzyme; Provisional; Region: PRK05402 768493015082 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 768493015083 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 768493015084 active site 768493015085 catalytic site [active] 768493015086 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 768493015087 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 768493015088 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 768493015089 putative antibiotic transporter; Provisional; Region: PRK10739 768493015090 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 768493015091 ATP-binding site [chemical binding]; other site 768493015092 Gluconate-6-phosphate binding site [chemical binding]; other site 768493015093 high-affinity gluconate transporter; Provisional; Region: PRK14984 768493015094 gluconate transporter; Region: gntP; TIGR00791 768493015095 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 768493015096 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768493015097 DNA binding site [nucleotide binding] 768493015098 domain linker motif; other site 768493015099 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 768493015100 putative ligand binding site [chemical binding]; other site 768493015101 putative dimerization interface [polypeptide binding]; other site 768493015102 Pirin-related protein [General function prediction only]; Region: COG1741 768493015103 Pirin; Region: Pirin; pfam02678 768493015104 putative acetyltransferase YhhY; Provisional; Region: PRK10140 768493015105 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493015106 Coenzyme A binding pocket [chemical binding]; other site 768493015107 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 768493015108 putative active site pocket [active] 768493015109 cleavage site 768493015110 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 768493015111 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 768493015112 Metal-binding active site; metal-binding site 768493015113 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 768493015114 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768493015115 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768493015116 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 768493015117 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 768493015118 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768493015119 PYR/PP interface [polypeptide binding]; other site 768493015120 dimer interface [polypeptide binding]; other site 768493015121 TPP binding site [chemical binding]; other site 768493015122 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768493015123 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 768493015124 TPP-binding site; other site 768493015125 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768493015126 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 768493015127 substrate binding site [chemical binding]; other site 768493015128 ATP binding site [chemical binding]; other site 768493015129 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 768493015130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 768493015131 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 768493015132 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768493015133 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768493015134 putative active site [active] 768493015135 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 768493015136 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 768493015137 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 768493015138 tetrameric interface [polypeptide binding]; other site 768493015139 NAD binding site [chemical binding]; other site 768493015140 catalytic residues [active] 768493015141 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 768493015142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493015143 putative substrate translocation pore; other site 768493015144 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493015145 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 768493015146 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 768493015147 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 768493015148 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768493015149 Walker A/P-loop; other site 768493015150 ATP binding site [chemical binding]; other site 768493015151 Q-loop/lid; other site 768493015152 ABC transporter signature motif; other site 768493015153 Walker B; other site 768493015154 D-loop; other site 768493015155 H-loop/switch region; other site 768493015156 FaeA-like protein; Region: FaeA; pfam04703 768493015157 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 768493015158 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 768493015159 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 768493015160 Fimbrial protein; Region: Fimbrial; cl01416 768493015161 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 768493015162 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 768493015163 PapC N-terminal domain; Region: PapC_N; pfam13954 768493015164 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 768493015165 PapC C-terminal domain; Region: PapC_C; pfam13953 768493015166 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 768493015167 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 768493015168 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 768493015169 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 768493015170 Fimbrial protein; Region: Fimbrial; cl01416 768493015171 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 768493015172 O-Antigen ligase; Region: Wzy_C; pfam04932 768493015173 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 768493015174 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768493015175 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768493015176 DNA binding residues [nucleotide binding] 768493015177 dimerization interface [polypeptide binding]; other site 768493015178 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 768493015179 Amidinotransferase; Region: Amidinotransf; pfam02274 768493015180 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768493015181 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768493015182 putative DNA binding site [nucleotide binding]; other site 768493015183 putative Zn2+ binding site [ion binding]; other site 768493015184 AsnC family; Region: AsnC_trans_reg; pfam01037 768493015185 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 768493015186 active site 768493015187 Mn binding site [ion binding]; other site 768493015188 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502 768493015189 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 768493015190 Protein of unknown function (DUF330); Region: DUF330; pfam03886 768493015191 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 768493015192 mce related protein; Region: MCE; pfam02470 768493015193 mce related protein; Region: MCE; pfam02470 768493015194 mce related protein; Region: MCE; pfam02470 768493015195 Paraquat-inducible protein A; Region: PqiA; pfam04403 768493015196 Paraquat-inducible protein A; Region: PqiA; pfam04403 768493015197 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 768493015198 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768493015199 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768493015200 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 768493015201 Predicted flavoproteins [General function prediction only]; Region: COG2081 768493015202 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 768493015203 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 768493015204 universal stress protein UspB; Provisional; Region: PRK04960 768493015205 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 768493015206 Ligand Binding Site [chemical binding]; other site 768493015207 glutamate dehydrogenase; Provisional; Region: PRK09414 768493015208 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 768493015209 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 768493015210 NAD(P) binding site [chemical binding]; other site 768493015211 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 768493015212 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 768493015213 ligand binding site [chemical binding]; other site 768493015214 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 768493015215 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768493015216 Walker A/P-loop; other site 768493015217 ATP binding site [chemical binding]; other site 768493015218 Q-loop/lid; other site 768493015219 ABC transporter signature motif; other site 768493015220 Walker B; other site 768493015221 D-loop; other site 768493015222 H-loop/switch region; other site 768493015223 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768493015224 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768493015225 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768493015226 TM-ABC transporter signature motif; other site 768493015227 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768493015228 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768493015229 TM-ABC transporter signature motif; other site 768493015230 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 768493015231 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 768493015232 N- and C-terminal domain interface [polypeptide binding]; other site 768493015233 active site 768493015234 MgATP binding site [chemical binding]; other site 768493015235 catalytic site [active] 768493015236 metal binding site [ion binding]; metal-binding site 768493015237 carbohydrate binding site [chemical binding]; other site 768493015238 putative homodimer interface [polypeptide binding]; other site 768493015239 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 768493015240 putative active site [active] 768493015241 putative methyltransferase; Provisional; Region: PRK10742 768493015242 oligopeptidase A; Provisional; Region: PRK10911 768493015243 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 768493015244 active site 768493015245 Zn binding site [ion binding]; other site 768493015246 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 768493015247 nucleotide binding site/active site [active] 768493015248 HIT family signature motif; other site 768493015249 catalytic residue [active] 768493015250 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 768493015251 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 768493015252 glutathione reductase; Validated; Region: PRK06116 768493015253 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768493015254 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768493015255 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768493015256 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 768493015257 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 768493015258 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 768493015259 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 768493015260 haemagglutination activity domain; Region: Haemagg_act; pfam05860 768493015261 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768493015262 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768493015263 DNA binding residues [nucleotide binding] 768493015264 dimerization interface [polypeptide binding]; other site 768493015265 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 768493015266 O-Antigen ligase; Region: Wzy_C; pfam04932 768493015267 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 768493015268 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 768493015269 Fimbrial protein; Region: Fimbrial; pfam00419 768493015270 Fimbrial protein; Region: Fimbrial; pfam00419 768493015271 Fimbrial protein; Region: Fimbrial; cl01416 768493015272 fimbrial assembly chaperone StbE; Provisional; Region: PRK15246 768493015273 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 768493015274 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 768493015275 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 768493015276 PapC N-terminal domain; Region: PapC_N; pfam13954 768493015277 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 768493015278 PapC C-terminal domain; Region: PapC_C; pfam13953 768493015279 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 768493015280 Fimbrial protein; Region: Fimbrial; cl01416 768493015281 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 768493015282 DNA binding site [nucleotide binding] 768493015283 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 768493015284 DNA binding site [nucleotide binding] 768493015285 haemagglutination activity domain; Region: Haemagg_act; pfam05860 768493015286 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 768493015287 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 768493015288 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 768493015289 DinB family; Region: DinB; cl17821 768493015290 DinB superfamily; Region: DinB_2; pfam12867 768493015291 Cupin; Region: Cupin_6; pfam12852 768493015292 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493015293 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768493015294 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493015295 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 768493015296 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768493015297 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768493015298 dimer interface [polypeptide binding]; other site 768493015299 phosphorylation site [posttranslational modification] 768493015300 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493015301 ATP binding site [chemical binding]; other site 768493015302 Mg2+ binding site [ion binding]; other site 768493015303 G-X-G motif; other site 768493015304 Response regulator receiver domain; Region: Response_reg; pfam00072 768493015305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493015306 active site 768493015307 phosphorylation site [posttranslational modification] 768493015308 intermolecular recognition site; other site 768493015309 dimerization interface [polypeptide binding]; other site 768493015310 BetR domain; Region: BetR; pfam08667 768493015311 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 768493015312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 768493015313 active site 768493015314 phosphorylation site [posttranslational modification] 768493015315 intermolecular recognition site; other site 768493015316 dimerization interface [polypeptide binding]; other site 768493015317 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 768493015318 catalytic triad [active] 768493015319 putative active site [active] 768493015320 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 768493015321 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 768493015322 Autotransporter beta-domain; Region: Autotransporter; pfam03797 768493015323 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 768493015324 catalytic triad [active] 768493015325 putative active site [active] 768493015326 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 768493015327 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 768493015328 Autotransporter beta-domain; Region: Autotransporter; pfam03797 768493015329 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768493015330 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768493015331 hypothetical protein; Provisional; Region: PRK02399 768493015332 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 768493015333 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 768493015334 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 768493015335 dimer interface [polypeptide binding]; other site 768493015336 RNase II stability modulator; Provisional; Region: PRK10060 768493015337 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768493015338 putative active site [active] 768493015339 heme pocket [chemical binding]; other site 768493015340 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768493015341 metal binding site [ion binding]; metal-binding site 768493015342 active site 768493015343 I-site; other site 768493015344 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768493015345 enoyl-CoA hydratase; Validated; Region: PRK08788 768493015346 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768493015347 substrate binding site [chemical binding]; other site 768493015348 oxyanion hole (OAH) forming residues; other site 768493015349 trimer interface [polypeptide binding]; other site 768493015350 inner membrane protein YhjD; Region: TIGR00766 768493015351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493015352 metabolite-proton symporter; Region: 2A0106; TIGR00883 768493015353 putative substrate translocation pore; other site 768493015354 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 768493015355 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 768493015356 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 768493015357 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768493015358 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 768493015359 active site 1 [active] 768493015360 dimer interface [polypeptide binding]; other site 768493015361 hexamer interface [polypeptide binding]; other site 768493015362 active site 2 [active] 768493015363 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768493015364 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 768493015365 substrate binding site [chemical binding]; other site 768493015366 ATP binding site [chemical binding]; other site 768493015367 ketol-acid reductoisomerase; Validated; Region: PRK05225 768493015368 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 768493015369 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 768493015370 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 768493015371 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493015372 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 768493015373 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 768493015374 putative dimerization interface [polypeptide binding]; other site 768493015375 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 768493015376 threonine dehydratase; Reviewed; Region: PRK09224 768493015377 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 768493015378 tetramer interface [polypeptide binding]; other site 768493015379 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493015380 catalytic residue [active] 768493015381 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 768493015382 putative Ile/Val binding site [chemical binding]; other site 768493015383 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 768493015384 putative Ile/Val binding site [chemical binding]; other site 768493015385 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 768493015386 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 768493015387 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 768493015388 homodimer interface [polypeptide binding]; other site 768493015389 substrate-cofactor binding pocket; other site 768493015390 catalytic residue [active] 768493015391 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 768493015392 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 768493015393 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768493015394 PYR/PP interface [polypeptide binding]; other site 768493015395 dimer interface [polypeptide binding]; other site 768493015396 TPP binding site [chemical binding]; other site 768493015397 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768493015398 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 768493015399 TPP-binding site [chemical binding]; other site 768493015400 dimer interface [polypeptide binding]; other site 768493015401 ilvG operon leader peptide; Provisional; Region: PRK10424 768493015402 putative sialic acid transporter; Region: 2A0112; TIGR00891 768493015403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493015404 putative substrate translocation pore; other site 768493015405 putative ATP-dependent protease; Provisional; Region: PRK09862 768493015406 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 768493015407 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768493015408 Walker A motif; other site 768493015409 ATP binding site [chemical binding]; other site 768493015410 Walker B motif; other site 768493015411 arginine finger; other site 768493015412 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 768493015413 hypothetical protein; Provisional; Region: PRK11027 768493015414 transcriptional regulator HdfR; Provisional; Region: PRK03601 768493015415 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493015416 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768493015417 dimerization interface [polypeptide binding]; other site 768493015418 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768493015419 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768493015420 TM-ABC transporter signature motif; other site 768493015421 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768493015422 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768493015423 TM-ABC transporter signature motif; other site 768493015424 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 768493015425 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768493015426 Walker A/P-loop; other site 768493015427 ATP binding site [chemical binding]; other site 768493015428 Q-loop/lid; other site 768493015429 ABC transporter signature motif; other site 768493015430 Walker B; other site 768493015431 D-loop; other site 768493015432 H-loop/switch region; other site 768493015433 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768493015434 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 768493015435 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 768493015436 putative ligand binding site [chemical binding]; other site 768493015437 glutamate racemase; Provisional; Region: PRK00865 768493015438 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 768493015439 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768493015440 N-terminal plug; other site 768493015441 ligand-binding site [chemical binding]; other site 768493015442 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 768493015443 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493015444 S-adenosylmethionine binding site [chemical binding]; other site 768493015445 hypothetical protein; Provisional; Region: PRK11056 768493015446 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 768493015447 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768493015448 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 768493015449 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768493015450 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768493015451 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 768493015452 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493015453 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 768493015454 dimerization interface [polypeptide binding]; other site 768493015455 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 768493015456 catalytic triad [active] 768493015457 dimer interface [polypeptide binding]; other site 768493015458 Glutaredoxin (GRX) family, PRX5 hybrid subfamily; composed of hybrid proteins containing peroxiredoxin (PRX) and GRX domains, which is found in some pathogenic bacteria and cyanobacteria. PRXs are thiol-specific antioxidant (TSA) proteins that confer a...; Region: GRX_hybridPRX5; cd03029 768493015459 GSH binding site [chemical binding]; other site 768493015460 catalytic residues [active] 768493015461 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 768493015462 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768493015463 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768493015464 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768493015465 argininosuccinate lyase; Provisional; Region: PRK04833 768493015466 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 768493015467 active sites [active] 768493015468 tetramer interface [polypeptide binding]; other site 768493015469 argininosuccinate synthase; Provisional; Region: PRK13820 768493015470 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 768493015471 ANP binding site [chemical binding]; other site 768493015472 Substrate Binding Site II [chemical binding]; other site 768493015473 Substrate Binding Site I [chemical binding]; other site 768493015474 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 768493015475 nucleotide binding site [chemical binding]; other site 768493015476 N-acetyl-L-glutamate binding site [chemical binding]; other site 768493015477 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 768493015478 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 768493015479 acetylornithine deacetylase; Provisional; Region: PRK05111 768493015480 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 768493015481 metal binding site [ion binding]; metal-binding site 768493015482 putative dimer interface [polypeptide binding]; other site 768493015483 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 768493015484 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 768493015485 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768493015486 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493015487 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768493015488 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768493015489 LysE type translocator; Region: LysE; pfam01810 768493015490 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 768493015491 FAD binding site [chemical binding]; other site 768493015492 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 768493015493 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 768493015494 putative catalytic residues [active] 768493015495 putative nucleotide binding site [chemical binding]; other site 768493015496 putative aspartate binding site [chemical binding]; other site 768493015497 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 768493015498 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 768493015499 cystathionine gamma-synthase; Provisional; Region: PRK08045 768493015500 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 768493015501 homodimer interface [polypeptide binding]; other site 768493015502 substrate-cofactor binding pocket; other site 768493015503 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493015504 catalytic residue [active] 768493015505 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 768493015506 dimerization interface [polypeptide binding]; other site 768493015507 DNA binding site [nucleotide binding] 768493015508 corepressor binding sites; other site 768493015509 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 768493015510 primosome assembly protein PriA; Validated; Region: PRK05580 768493015511 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768493015512 ATP binding site [chemical binding]; other site 768493015513 putative Mg++ binding site [ion binding]; other site 768493015514 DAN domain; Region: DAN; cl17734 768493015515 helicase superfamily c-terminal domain; Region: HELICc; smart00490 768493015516 ATP-binding site [chemical binding]; other site 768493015517 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768493015518 DNA binding site [nucleotide binding] 768493015519 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 768493015520 domain linker motif; other site 768493015521 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 768493015522 dimerization interface [polypeptide binding]; other site 768493015523 ligand binding site [chemical binding]; other site 768493015524 Sporulation related domain; Region: SPOR; cl10051 768493015525 cell division protein FtsN; Provisional; Region: PRK12757 768493015526 Sporulation related domain; Region: SPOR; cl10051 768493015527 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 768493015528 active site 768493015529 HslU subunit interaction site [polypeptide binding]; other site 768493015530 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 768493015531 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768493015532 Walker A motif; other site 768493015533 ATP binding site [chemical binding]; other site 768493015534 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 768493015535 Walker B motif; other site 768493015536 arginine finger; other site 768493015537 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 768493015538 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 768493015539 UbiA prenyltransferase family; Region: UbiA; pfam01040 768493015540 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 768493015541 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3074 768493015542 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 768493015543 amphipathic channel; other site 768493015544 Asn-Pro-Ala signature motifs; other site 768493015545 glycerol kinase; Provisional; Region: glpK; PRK00047 768493015546 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 768493015547 N- and C-terminal domain interface [polypeptide binding]; other site 768493015548 active site 768493015549 MgATP binding site [chemical binding]; other site 768493015550 catalytic site [active] 768493015551 metal binding site [ion binding]; metal-binding site 768493015552 glycerol binding site [chemical binding]; other site 768493015553 homotetramer interface [polypeptide binding]; other site 768493015554 homodimer interface [polypeptide binding]; other site 768493015555 FBP binding site [chemical binding]; other site 768493015556 protein IIAGlc interface [polypeptide binding]; other site 768493015557 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 768493015558 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 768493015559 putative active site [active] 768493015560 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 768493015561 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493015562 putative substrate translocation pore; other site 768493015563 Predicted transcriptional regulator [Transcription]; Region: COG2345 768493015564 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 768493015565 ferredoxin-NADP reductase; Provisional; Region: PRK10926 768493015566 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 768493015567 FAD binding pocket [chemical binding]; other site 768493015568 FAD binding motif [chemical binding]; other site 768493015569 phosphate binding motif [ion binding]; other site 768493015570 beta-alpha-beta structure motif; other site 768493015571 NAD binding pocket [chemical binding]; other site 768493015572 Predicted membrane protein [Function unknown]; Region: COG3152 768493015573 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 768493015574 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 768493015575 triosephosphate isomerase; Provisional; Region: PRK14567 768493015576 substrate binding site [chemical binding]; other site 768493015577 dimer interface [polypeptide binding]; other site 768493015578 catalytic triad [active] 768493015579 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768493015580 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 768493015581 substrate binding pocket [chemical binding]; other site 768493015582 membrane-bound complex binding site; other site 768493015583 hinge residues; other site 768493015584 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 768493015585 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 768493015586 active site 768493015587 ADP/pyrophosphate binding site [chemical binding]; other site 768493015588 dimerization interface [polypeptide binding]; other site 768493015589 allosteric effector site; other site 768493015590 fructose-1,6-bisphosphate binding site; other site 768493015591 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 768493015592 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 768493015593 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 768493015594 dimer interface [polypeptide binding]; other site 768493015595 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 768493015596 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493015597 active site 768493015598 phosphorylation site [posttranslational modification] 768493015599 intermolecular recognition site; other site 768493015600 dimerization interface [polypeptide binding]; other site 768493015601 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768493015602 DNA binding site [nucleotide binding] 768493015603 two-component sensor protein; Provisional; Region: cpxA; PRK09470 768493015604 HAMP domain; Region: HAMP; pfam00672 768493015605 dimerization interface [polypeptide binding]; other site 768493015606 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768493015607 dimer interface [polypeptide binding]; other site 768493015608 phosphorylation site [posttranslational modification] 768493015609 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493015610 ATP binding site [chemical binding]; other site 768493015611 Mg2+ binding site [ion binding]; other site 768493015612 G-X-G motif; other site 768493015613 putative rRNA methylase; Provisional; Region: PRK10358 768493015614 CHAD domain; Region: CHAD; pfam05235 768493015615 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 768493015616 serine acetyltransferase; Provisional; Region: cysE; PRK11132 768493015617 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 768493015618 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 768493015619 trimer interface [polypeptide binding]; other site 768493015620 active site 768493015621 substrate binding site [chemical binding]; other site 768493015622 CoA binding site [chemical binding]; other site 768493015623 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 768493015624 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 768493015625 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 768493015626 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 768493015627 SecA binding site; other site 768493015628 Preprotein binding site; other site 768493015629 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 768493015630 GSH binding site [chemical binding]; other site 768493015631 catalytic residues [active] 768493015632 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 768493015633 active site residue [active] 768493015634 phosphoglyceromutase; Provisional; Region: PRK05434 768493015635 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 768493015636 AmiB activator; Provisional; Region: PRK11637 768493015637 Peptidase family M23; Region: Peptidase_M23; pfam01551 768493015638 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 768493015639 NodB motif; other site 768493015640 putative active site [active] 768493015641 putative catalytic site [active] 768493015642 Zn binding site [ion binding]; other site 768493015643 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 768493015644 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 768493015645 NAD(P) binding site [chemical binding]; other site 768493015646 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 768493015647 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 768493015648 substrate-cofactor binding pocket; other site 768493015649 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768493015650 catalytic residue [active] 768493015651 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 768493015652 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 768493015653 NADP binding site [chemical binding]; other site 768493015654 homopentamer interface [polypeptide binding]; other site 768493015655 substrate binding site [chemical binding]; other site 768493015656 active site 768493015657 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 768493015658 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 768493015659 putative active site [active] 768493015660 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 768493015661 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 768493015662 putative active site [active] 768493015663 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768493015664 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 768493015665 putative glycosyl transferase; Provisional; Region: PRK10073 768493015666 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 768493015667 active site 768493015668 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 768493015669 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 768493015670 putative active site [active] 768493015671 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 768493015672 putative active site [active] 768493015673 putative catalytic site [active] 768493015674 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 768493015675 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 768493015676 putative active site [active] 768493015677 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768493015678 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 768493015679 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768493015680 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 768493015681 putative ADP-binding pocket [chemical binding]; other site 768493015682 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 768493015683 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 768493015684 putative active site [active] 768493015685 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 768493015686 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 768493015687 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 768493015688 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 768493015689 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 768493015690 putative metal binding site; other site 768493015691 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 768493015692 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 768493015693 active site 768493015694 (T/H)XGH motif; other site 768493015695 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 768493015696 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 768493015697 DNA binding site [nucleotide binding] 768493015698 catalytic residue [active] 768493015699 H2TH interface [polypeptide binding]; other site 768493015700 putative catalytic residues [active] 768493015701 turnover-facilitating residue; other site 768493015702 intercalation triad [nucleotide binding]; other site 768493015703 8OG recognition residue [nucleotide binding]; other site 768493015704 putative reading head residues; other site 768493015705 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 768493015706 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 768493015707 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 768493015708 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 768493015709 hypothetical protein; Reviewed; Region: PRK00024 768493015710 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 768493015711 MPN+ (JAMM) motif; other site 768493015712 Zinc-binding site [ion binding]; other site 768493015713 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 768493015714 Flavoprotein; Region: Flavoprotein; pfam02441 768493015715 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 768493015716 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 768493015717 trimer interface [polypeptide binding]; other site 768493015718 active site 768493015719 division inhibitor protein; Provisional; Region: slmA; PRK09480 768493015720 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768493015721 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768493015722 active site 768493015723 ribonuclease PH; Reviewed; Region: rph; PRK00173 768493015724 Ribonuclease PH; Region: RNase_PH_bact; cd11362 768493015725 hexamer interface [polypeptide binding]; other site 768493015726 active site 768493015727 hypothetical protein; Provisional; Region: PRK11820 768493015728 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 768493015729 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 768493015730 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 768493015731 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 768493015732 Nucleoside recognition; Region: Gate; pfam07670 768493015733 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 768493015734 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 768493015735 Predicted membrane protein [Function unknown]; Region: COG2860 768493015736 UPF0126 domain; Region: UPF0126; pfam03458 768493015737 UPF0126 domain; Region: UPF0126; pfam03458 768493015738 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768493015739 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768493015740 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 768493015741 putative effector binding pocket; other site 768493015742 putative dimerization interface [polypeptide binding]; other site 768493015743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493015744 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768493015745 putative substrate translocation pore; other site 768493015746 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 768493015747 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 768493015748 catalytic site [active] 768493015749 G-X2-G-X-G-K; other site 768493015750 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 768493015751 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 768493015752 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768493015753 Zn2+ binding site [ion binding]; other site 768493015754 Mg2+ binding site [ion binding]; other site 768493015755 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 768493015756 synthetase active site [active] 768493015757 NTP binding site [chemical binding]; other site 768493015758 metal binding site [ion binding]; metal-binding site 768493015759 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 768493015760 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 768493015761 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 768493015762 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 768493015763 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 768493015764 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 768493015765 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 768493015766 generic binding surface II; other site 768493015767 ssDNA binding site; other site 768493015768 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768493015769 ATP binding site [chemical binding]; other site 768493015770 putative Mg++ binding site [ion binding]; other site 768493015771 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768493015772 nucleotide binding region [chemical binding]; other site 768493015773 ATP-binding site [chemical binding]; other site 768493015774 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 768493015775 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 768493015776 AsmA family; Region: AsmA; pfam05170 768493015777 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768493015778 Coenzyme A binding pocket [chemical binding]; other site 768493015779 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 768493015780 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 768493015781 putative active site [active] 768493015782 dimerization interface [polypeptide binding]; other site 768493015783 putative tRNAtyr binding site [nucleotide binding]; other site 768493015784 hypothetical protein; Reviewed; Region: PRK01637 768493015785 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 768493015786 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768493015787 motif II; other site 768493015788 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 768493015789 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 768493015790 G1 box; other site 768493015791 putative GEF interaction site [polypeptide binding]; other site 768493015792 GTP/Mg2+ binding site [chemical binding]; other site 768493015793 Switch I region; other site 768493015794 G2 box; other site 768493015795 G3 box; other site 768493015796 Switch II region; other site 768493015797 G4 box; other site 768493015798 G5 box; other site 768493015799 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 768493015800 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 768493015801 glutamine synthetase; Provisional; Region: glnA; PRK09469 768493015802 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 768493015803 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 768493015804 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 768493015805 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768493015806 dimer interface [polypeptide binding]; other site 768493015807 phosphorylation site [posttranslational modification] 768493015808 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768493015809 ATP binding site [chemical binding]; other site 768493015810 Mg2+ binding site [ion binding]; other site 768493015811 G-X-G motif; other site 768493015812 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 768493015813 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768493015814 active site 768493015815 phosphorylation site [posttranslational modification] 768493015816 intermolecular recognition site; other site 768493015817 dimerization interface [polypeptide binding]; other site 768493015818 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768493015819 Walker A motif; other site 768493015820 ATP binding site [chemical binding]; other site 768493015821 Walker B motif; other site 768493015822 arginine finger; other site 768493015823 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768493015824 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 768493015825 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768493015826 FeS/SAM binding site; other site 768493015827 HemN C-terminal domain; Region: HemN_C; pfam06969 768493015828 Der GTPase activator; Provisional; Region: PRK05244 768493015829 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 768493015830 G1 box; other site 768493015831 GTP/Mg2+ binding site [chemical binding]; other site 768493015832 Switch I region; other site 768493015833 G2 box; other site 768493015834 G3 box; other site 768493015835 Switch II region; other site 768493015836 G4 box; other site 768493015837 G5 box; other site 768493015838 DNA polymerase I; Provisional; Region: PRK05755 768493015839 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 768493015840 active site 768493015841 metal binding site 1 [ion binding]; metal-binding site 768493015842 putative 5' ssDNA interaction site; other site 768493015843 metal binding site 3; metal-binding site 768493015844 metal binding site 2 [ion binding]; metal-binding site 768493015845 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 768493015846 putative DNA binding site [nucleotide binding]; other site 768493015847 putative metal binding site [ion binding]; other site 768493015848 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 768493015849 active site 768493015850 catalytic site [active] 768493015851 substrate binding site [chemical binding]; other site 768493015852 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 768493015853 active site 768493015854 DNA binding site [nucleotide binding] 768493015855 catalytic site [active] 768493015856 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 768493015857 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 768493015858 putative acyl-acceptor binding pocket; other site 768493015859 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 768493015860 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 768493015861 catalytic residues [active] 768493015862 hinge region; other site 768493015863 alpha helical domain; other site 768493015864 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 768493015865 serine/threonine protein kinase; Provisional; Region: PRK11768 768493015866 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 768493015867 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 768493015868 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 768493015869 GTP binding site; other site 768493015870 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 768493015871 Walker A motif; other site 768493015872 Transcriptional regulators [Transcription]; Region: FadR; COG2186 768493015873 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768493015874 DNA-binding site [nucleotide binding]; DNA binding site 768493015875 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 768493015876 putative transporter; Provisional; Region: PRK10504 768493015877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768493015878 putative substrate translocation pore; other site 768493015879 transcriptional repressor RbsR; Provisional; Region: PRK10423 768493015880 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768493015881 DNA binding site [nucleotide binding] 768493015882 domain linker motif; other site 768493015883 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 768493015884 dimerization interface [polypeptide binding]; other site 768493015885 ligand binding site [chemical binding]; other site 768493015886 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768493015887 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 768493015888 substrate binding site [chemical binding]; other site 768493015889 dimer interface [polypeptide binding]; other site 768493015890 ATP binding site [chemical binding]; other site 768493015891 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 768493015892 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 768493015893 ligand binding site [chemical binding]; other site 768493015894 dimerization interface [polypeptide binding]; other site 768493015895 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768493015896 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768493015897 TM-ABC transporter signature motif; other site 768493015898 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 768493015899 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768493015900 Walker A/P-loop; other site 768493015901 ATP binding site [chemical binding]; other site 768493015902 Q-loop/lid; other site 768493015903 ABC transporter signature motif; other site 768493015904 Walker B; other site 768493015905 D-loop; other site 768493015906 H-loop/switch region; other site 768493015907 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768493015908 D-ribose pyranase; Provisional; Region: PRK11797 768493015909 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 768493015910 potassium uptake protein; Region: kup; TIGR00794 768493015911 regulatory ATPase RavA; Provisional; Region: PRK13531 768493015912 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768493015913 Walker A motif; other site 768493015914 ATP binding site [chemical binding]; other site 768493015915 Walker B motif; other site 768493015916 arginine finger; other site 768493015917 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 768493015918 hypothetical protein; Provisional; Region: yieM; PRK10997 768493015919 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 768493015920 metal ion-dependent adhesion site (MIDAS); other site 768493015921 Asparagine synthetase A [Amino acid transport and metabolism]; Region: AsnA; COG2502 768493015922 motif 1; other site 768493015923 dimer interface [polypeptide binding]; other site 768493015924 active site 768493015925 motif 2; other site 768493015926 motif 3; other site 768493015927 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 768493015928 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768493015929 dimerization interface [polypeptide binding]; other site 768493015930 putative DNA binding site [nucleotide binding]; other site 768493015931 putative Zn2+ binding site [ion binding]; other site 768493015932 AsnC family; Region: AsnC_trans_reg; pfam01037 768493015933 FMN-binding protein MioC; Provisional; Region: PRK09004 768493015934 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 768493015935 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 768493015936 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 768493015937 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 768493015938 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768493015939 S-adenosylmethionine binding site [chemical binding]; other site 768493015940 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 768493015941 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 768493015942 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 768493015943 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 768493015944 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 768493015945 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 768493015946 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 768493015947 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 768493015948 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 768493015949 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 768493015950 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 768493015951 beta subunit interaction interface [polypeptide binding]; other site 768493015952 Walker A motif; other site 768493015953 ATP binding site [chemical binding]; other site 768493015954 Walker B motif; other site 768493015955 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 768493015956 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 768493015957 core domain interface [polypeptide binding]; other site 768493015958 delta subunit interface [polypeptide binding]; other site 768493015959 epsilon subunit interface [polypeptide binding]; other site 768493015960 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 768493015961 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 768493015962 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 768493015963 alpha subunit interaction interface [polypeptide binding]; other site 768493015964 Walker A motif; other site 768493015965 ATP binding site [chemical binding]; other site 768493015966 Walker B motif; other site 768493015967 inhibitor binding site; inhibition site 768493015968 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 768493015969 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 768493015970 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 768493015971 gamma subunit interface [polypeptide binding]; other site 768493015972 epsilon subunit interface [polypeptide binding]; other site 768493015973 LBP interface [polypeptide binding]; other site 768493015974 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 768493015975 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 768493015976 Substrate binding site; other site 768493015977 Mg++ binding site; other site 768493015978 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 768493015979 active site 768493015980 substrate binding site [chemical binding]; other site 768493015981 CoA binding site [chemical binding]; other site 768493015982 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 768493015983 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 768493015984 glutaminase active site [active] 768493015985 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 768493015986 dimer interface [polypeptide binding]; other site 768493015987 active site 768493015988 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 768493015989 dimer interface [polypeptide binding]; other site 768493015990 active site 768493015991 AAA domain; Region: AAA_13; pfam13166 768493015992 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768493015993 substrate binding pocket [chemical binding]; other site 768493015994 membrane-bound complex binding site; other site 768493015995 hinge residues; other site 768493015996 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 768493015997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493015998 dimer interface [polypeptide binding]; other site 768493015999 conserved gate region; other site 768493016000 putative PBP binding loops; other site 768493016001 ABC-ATPase subunit interface; other site 768493016002 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 768493016003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493016004 dimer interface [polypeptide binding]; other site 768493016005 conserved gate region; other site 768493016006 putative PBP binding loops; other site 768493016007 ABC-ATPase subunit interface; other site 768493016008 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 768493016009 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 768493016010 Walker A/P-loop; other site 768493016011 ATP binding site [chemical binding]; other site 768493016012 Q-loop/lid; other site 768493016013 ABC transporter signature motif; other site 768493016014 Walker B; other site 768493016015 D-loop; other site 768493016016 H-loop/switch region; other site 768493016017 transcriptional regulator PhoU; Provisional; Region: PRK11115 768493016018 PhoU domain; Region: PhoU; pfam01895 768493016019 PhoU domain; Region: PhoU; pfam01895 768493016020 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768493016021 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768493016022 substrate binding pocket [chemical binding]; other site 768493016023 membrane-bound complex binding site; other site 768493016024 hinge residues; other site 768493016025 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493016026 dimer interface [polypeptide binding]; other site 768493016027 conserved gate region; other site 768493016028 putative PBP binding loops; other site 768493016029 ABC-ATPase subunit interface; other site 768493016030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768493016031 dimer interface [polypeptide binding]; other site 768493016032 conserved gate region; other site 768493016033 putative PBP binding loops; other site 768493016034 ABC-ATPase subunit interface; other site 768493016035 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 768493016036 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768493016037 motif II; other site 768493016038 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 768493016039 Predicted esterase [General function prediction only]; Region: COG0400 768493016040 Predicted flavoprotein [General function prediction only]; Region: COG0431 768493016041 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768493016042 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 768493016043 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 768493016044 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 768493016045 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 768493016046 trmE is a tRNA modification GTPase; Region: trmE; cd04164 768493016047 G1 box; other site 768493016048 GTP/Mg2+ binding site [chemical binding]; other site 768493016049 Switch I region; other site 768493016050 G2 box; other site 768493016051 Switch II region; other site 768493016052 G3 box; other site 768493016053 G4 box; other site 768493016054 G5 box; other site 768493016055 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 768493016056 membrane protein insertase; Provisional; Region: PRK01318 768493016057 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 768493016058 hypothetical protein; Validated; Region: PRK00041 768493016059 ribonuclease P; Reviewed; Region: rnpA; PRK01732 768493016060 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399