-- dump date 20120504_161412 -- class Genbank::misc_feature -- table misc_feature_note -- id note 768492000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 768492000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 768492000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492000004 Walker A motif; other site 768492000005 ATP binding site [chemical binding]; other site 768492000006 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492000007 Walker B motif; other site 768492000008 arginine finger; other site 768492000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 768492000010 DnaA box-binding interface [nucleotide binding]; other site 768492000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 768492000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 768492000013 putative DNA binding surface [nucleotide binding]; other site 768492000014 dimer interface [polypeptide binding]; other site 768492000015 beta-clamp/clamp loader binding surface; other site 768492000016 beta-clamp/translesion DNA polymerase binding surface; other site 768492000017 recF protein; Region: recf; TIGR00611 768492000018 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492000019 Walker A/P-loop; other site 768492000020 ATP binding site [chemical binding]; other site 768492000021 Q-loop/lid; other site 768492000022 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492000023 ABC transporter signature motif; other site 768492000024 Walker B; other site 768492000025 D-loop; other site 768492000026 H-loop/switch region; other site 768492000027 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 768492000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 768492000029 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 768492000030 anchoring element; other site 768492000031 dimer interface [polypeptide binding]; other site 768492000032 ATP binding site [chemical binding]; other site 768492000033 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 768492000034 active site 768492000035 putative metal-binding site [ion binding]; other site 768492000036 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 768492000037 sugar phosphate phosphatase; Provisional; Region: PRK10513 768492000038 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492000039 active site 768492000040 motif I; other site 768492000041 motif II; other site 768492000042 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492000043 motif I; other site 768492000044 active site 768492000045 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 768492000046 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 768492000047 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492000048 hypothetical protein; Provisional; Region: PRK06815 768492000049 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 768492000050 tetramer interface [polypeptide binding]; other site 768492000051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492000052 catalytic residue [active] 768492000053 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 768492000054 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 768492000055 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 768492000056 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 768492000057 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 768492000058 putative dimer interface [polypeptide binding]; other site 768492000059 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 768492000060 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 768492000061 putative dimer interface [polypeptide binding]; other site 768492000062 putative transporter; Validated; Region: PRK03818 768492000063 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 768492000064 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 768492000065 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 768492000066 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 768492000067 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 768492000068 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492000069 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492000070 homodimer interface [polypeptide binding]; other site 768492000071 catalytic residue [active] 768492000072 alpha-amylase; Reviewed; Region: malS; PRK09505 768492000073 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 768492000074 active site 768492000075 catalytic site [active] 768492000076 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 768492000077 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 768492000078 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 768492000079 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492000080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492000081 D-galactonate transporter; Region: 2A0114; TIGR00893 768492000082 putative substrate translocation pore; other site 768492000083 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768492000084 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 768492000085 substrate binding site [chemical binding]; other site 768492000086 ATP binding site [chemical binding]; other site 768492000087 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 768492000088 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768492000089 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492000090 DNA binding site [nucleotide binding] 768492000091 domain linker motif; other site 768492000092 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 768492000093 putative dimerization interface [polypeptide binding]; other site 768492000094 putative ligand binding site [chemical binding]; other site 768492000095 putative outer membrane lipoprotein; Provisional; Region: PRK10510 768492000096 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 768492000097 ligand binding site [chemical binding]; other site 768492000098 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768492000099 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492000100 Coenzyme A binding pocket [chemical binding]; other site 768492000101 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 768492000102 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 768492000103 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 768492000104 active site 768492000105 catalytic triad [active] 768492000106 oxyanion hole [active] 768492000107 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 768492000108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492000109 D-galactonate transporter; Region: 2A0114; TIGR00893 768492000110 putative substrate translocation pore; other site 768492000111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492000112 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 768492000113 dimer interface [polypeptide binding]; other site 768492000114 motif 1; other site 768492000115 active site 768492000116 motif 2; other site 768492000117 motif 3; other site 768492000118 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 768492000119 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 768492000120 Fic family protein [Function unknown]; Region: COG3177 768492000121 Fic/DOC family; Region: Fic; cl00960 768492000122 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 768492000123 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 768492000124 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 768492000125 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 768492000126 active site 768492000127 P-loop; other site 768492000128 phosphorylation site [posttranslational modification] 768492000129 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 768492000130 active site 768492000131 phosphorylation site [posttranslational modification] 768492000132 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 768492000133 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 768492000134 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 768492000135 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 768492000136 Mannitol repressor; Region: MtlR; cl11450 768492000137 LysE type translocator; Region: LysE; cl00565 768492000138 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768492000139 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492000140 DNA-binding site [nucleotide binding]; DNA binding site 768492000141 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492000142 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492000143 homodimer interface [polypeptide binding]; other site 768492000144 catalytic residue [active] 768492000145 Protein of unknown function (DUF2810); Region: DUF2810; cl08159 768492000146 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492000147 S-adenosylmethionine binding site [chemical binding]; other site 768492000148 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 768492000149 MOSC domain; Region: MOSC; pfam03473 768492000150 3-alpha domain; Region: 3-alpha; pfam03475 768492000151 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768492000152 dimerization interface [polypeptide binding]; other site 768492000153 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 768492000154 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768492000155 dimer interface [polypeptide binding]; other site 768492000156 putative CheW interface [polypeptide binding]; other site 768492000157 superoxide dismutase; Provisional; Region: PRK10925 768492000158 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 768492000159 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 768492000160 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 768492000161 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 768492000162 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 768492000163 [4Fe-4S] binding site [ion binding]; other site 768492000164 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 768492000165 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 768492000166 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 768492000167 molybdopterin cofactor binding site; other site 768492000168 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 768492000169 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 768492000170 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 768492000171 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 768492000172 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 768492000173 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 768492000174 hypothetical protein; Provisional; Region: PRK11615 768492000175 putative glutathione S-transferase; Provisional; Region: PRK10357 768492000176 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 768492000177 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 768492000178 dimer interface [polypeptide binding]; other site 768492000179 N-terminal domain interface [polypeptide binding]; other site 768492000180 putative substrate binding pocket (H-site) [chemical binding]; other site 768492000181 selenocysteine synthase; Provisional; Region: PRK04311 768492000182 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 768492000183 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768492000184 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 768492000185 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 768492000186 G1 box; other site 768492000187 putative GEF interaction site [polypeptide binding]; other site 768492000188 GTP/Mg2+ binding site [chemical binding]; other site 768492000189 Switch I region; other site 768492000190 G2 box; other site 768492000191 G3 box; other site 768492000192 Switch II region; other site 768492000193 G4 box; other site 768492000194 G5 box; other site 768492000195 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 768492000196 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 768492000197 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 768492000198 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 768492000199 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 768492000200 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 768492000201 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 768492000202 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492000203 putative substrate translocation pore; other site 768492000204 OpgC protein; Region: OpgC_C; cl00792 768492000205 Acyltransferase family; Region: Acyl_transf_3; pfam01757 768492000206 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 768492000207 conserved cys residue [active] 768492000208 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492000209 Helix-turn-helix domain; Region: HTH_18; pfam12833 768492000210 Isochorismatase family; Region: Isochorismatase; pfam00857 768492000211 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 768492000212 catalytic triad [active] 768492000213 conserved cis-peptide bond; other site 768492000214 putative deaminase; Validated; Region: PRK06846 768492000215 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 768492000216 active site 768492000217 xylulokinase; Provisional; Region: PRK15027 768492000218 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 768492000219 N- and C-terminal domain interface [polypeptide binding]; other site 768492000220 active site 768492000221 catalytic site [active] 768492000222 metal binding site [ion binding]; metal-binding site 768492000223 xylulose binding site [chemical binding]; other site 768492000224 putative ATP binding site [chemical binding]; other site 768492000225 homodimer interface [polypeptide binding]; other site 768492000226 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 768492000227 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 768492000228 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 768492000229 putative ligand binding site [chemical binding]; other site 768492000230 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 768492000231 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 768492000232 Walker A/P-loop; other site 768492000233 ATP binding site [chemical binding]; other site 768492000234 Q-loop/lid; other site 768492000235 ABC transporter signature motif; other site 768492000236 Walker B; other site 768492000237 D-loop; other site 768492000238 H-loop/switch region; other site 768492000239 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 768492000240 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 768492000241 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768492000242 TM-ABC transporter signature motif; other site 768492000243 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 768492000244 putative dimerization interface [polypeptide binding]; other site 768492000245 putative ligand binding site [chemical binding]; other site 768492000246 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492000247 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768492000248 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492000249 Helix-turn-helix domains; Region: HTH; cl00088 768492000250 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492000251 dimerization interface [polypeptide binding]; other site 768492000252 putative cyanate transporter; Provisional; Region: cynX; PRK09705 768492000253 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492000254 putative substrate translocation pore; other site 768492000255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 768492000256 TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919 768492000257 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 768492000258 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 768492000259 active site 768492000260 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 768492000261 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39C; cd02419 768492000262 putative active site [active] 768492000263 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 768492000264 This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export...; Region: ABCC_Protease_Secretion; cd03246 768492000265 Walker A/P-loop; other site 768492000266 ATP binding site [chemical binding]; other site 768492000267 Q-loop/lid; other site 768492000268 ABC transporter signature motif; other site 768492000269 Walker B; other site 768492000270 D-loop; other site 768492000271 H-loop/switch region; other site 768492000272 HlyD family secretion protein; Region: HlyD; pfam00529 768492000273 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 768492000274 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 768492000275 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 768492000276 active site 768492000277 NTP binding site [chemical binding]; other site 768492000278 metal binding triad [ion binding]; metal-binding site 768492000279 Autoinducer binding domain; Region: Autoind_bind; pfam03472 768492000280 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492000281 DNA binding residues [nucleotide binding] 768492000282 dimerization interface [polypeptide binding]; other site 768492000283 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 768492000284 catalytic core [active] 768492000285 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 768492000286 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768492000287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492000288 putative substrate translocation pore; other site 768492000289 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492000290 Helix-turn-helix domains; Region: HTH; cl00088 768492000291 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492000292 putative effector binding pocket; other site 768492000293 dimerization interface [polypeptide binding]; other site 768492000294 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 768492000295 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492000296 NAD(P) binding site [chemical binding]; other site 768492000297 active site 768492000298 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492000299 Helix-turn-helix domains; Region: HTH; cl00088 768492000300 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768492000301 dimerization interface [polypeptide binding]; other site 768492000302 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 768492000303 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492000304 NAD(P) binding site [chemical binding]; other site 768492000305 active site 768492000306 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 768492000307 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768492000308 active site turn [active] 768492000309 phosphorylation site [posttranslational modification] 768492000310 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 768492000311 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 768492000312 HPr interaction site; other site 768492000313 glycerol kinase (GK) interaction site [polypeptide binding]; other site 768492000314 active site 768492000315 phosphorylation site [posttranslational modification] 768492000316 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 768492000317 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 768492000318 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 768492000319 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 768492000320 Transcriptional regulators [Transcription]; Region: MarR; COG1846 768492000321 Helix-turn-helix domains; Region: HTH; cl00088 768492000322 OsmC-like protein; Region: OsmC; cl00767 768492000323 phosphoethanolamine transferase; Provisional; Region: PRK11560 768492000324 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 768492000325 Sulfatase; Region: Sulfatase; cl10460 768492000326 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 768492000327 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492000328 active site 768492000329 phosphorylation site [posttranslational modification] 768492000330 intermolecular recognition site; other site 768492000331 dimerization interface [polypeptide binding]; other site 768492000332 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492000333 DNA binding residues [nucleotide binding] 768492000334 dimerization interface [polypeptide binding]; other site 768492000335 sensory histidine kinase UhpB; Provisional; Region: PRK11644 768492000336 MASE1; Region: MASE1; pfam05231 768492000337 MASE1; Region: MASE1; pfam05231 768492000338 Histidine kinase; Region: HisKA_3; pfam07730 768492000339 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492000340 ATP binding site [chemical binding]; other site 768492000341 Mg2+ binding site [ion binding]; other site 768492000342 G-X-G motif; other site 768492000343 regulatory protein UhpC; Provisional; Region: PRK11663 768492000344 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492000345 putative substrate translocation pore; other site 768492000346 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492000347 Predicted transcriptional regulator [Transcription]; Region: COG4190 768492000348 N-terminal Early set domain associated with the catalytic domain of chitinase; Region: E_set_Chitinase_N; cd02848 768492000349 Glyco_18 domain; Region: Glyco_18; smart00636 768492000350 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 768492000351 active site 768492000352 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 768492000353 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 768492000354 peptide binding site [polypeptide binding]; other site 768492000355 dipeptide transporter permease DppB; Provisional; Region: PRK10914 768492000356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492000357 dimer interface [polypeptide binding]; other site 768492000358 conserved gate region; other site 768492000359 putative PBP binding loops; other site 768492000360 ABC-ATPase subunit interface; other site 768492000361 dipeptide transporter; Provisional; Region: PRK10913 768492000362 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 768492000363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492000364 dimer interface [polypeptide binding]; other site 768492000365 conserved gate region; other site 768492000366 putative PBP binding loops; other site 768492000367 ABC-ATPase subunit interface; other site 768492000368 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 768492000369 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 768492000370 Walker A/P-loop; other site 768492000371 ATP binding site [chemical binding]; other site 768492000372 Q-loop/lid; other site 768492000373 ABC transporter signature motif; other site 768492000374 Walker B; other site 768492000375 D-loop; other site 768492000376 H-loop/switch region; other site 768492000377 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768492000378 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 768492000379 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 768492000380 Walker A/P-loop; other site 768492000381 ATP binding site [chemical binding]; other site 768492000382 Q-loop/lid; other site 768492000383 ABC transporter signature motif; other site 768492000384 Walker B; other site 768492000385 D-loop; other site 768492000386 H-loop/switch region; other site 768492000387 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768492000388 Protein of unknown function (DUF3260); Region: DUF3260; cl11881 768492000389 Protein of unknown function (DUF2636); Region: DUF2636; cl11897 768492000390 cellulose biosynthesis protein BcsE; Region: cellulose_bcsE; TIGR03369 768492000391 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 768492000392 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 768492000393 YhjQ protein; Region: YhjQ; pfam06564 768492000394 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492000395 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492000396 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 768492000397 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 768492000398 DXD motif; other site 768492000399 PilZ domain; Region: PilZ; cl01260 768492000400 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 768492000401 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 768492000402 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 768492000403 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768492000404 TPR motif; other site 768492000405 binding surface 768492000406 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768492000407 binding surface 768492000408 TPR motif; other site 768492000409 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768492000410 binding surface 768492000411 TPR motif; other site 768492000412 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 768492000413 binding surface 768492000414 TPR motif; other site 768492000415 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 768492000416 putative diguanylate cyclase; Provisional; Region: PRK13561 768492000417 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768492000418 metal binding site [ion binding]; metal-binding site 768492000419 active site 768492000420 I-site; other site 768492000421 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768492000422 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 768492000423 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 768492000424 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 768492000425 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 768492000426 PPIC-type PPIASE domain; Region: Rotamase; cl08278 768492000427 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 768492000428 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492000429 Family description; Region: UvrD_C_2; cl15862 768492000430 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 768492000431 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 768492000432 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 768492000433 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 768492000434 ATP binding site [chemical binding]; other site 768492000435 Mg++ binding site [ion binding]; other site 768492000436 motif III; other site 768492000437 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768492000438 nucleotide binding region [chemical binding]; other site 768492000439 ATP-binding site [chemical binding]; other site 768492000440 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 768492000441 catalytic residues [active] 768492000442 transcription termination factor Rho; Provisional; Region: rho; PRK09376 768492000443 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 768492000444 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 768492000445 RNA binding site [nucleotide binding]; other site 768492000446 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 768492000447 multimer interface [polypeptide binding]; other site 768492000448 Walker A motif; other site 768492000449 ATP binding site [chemical binding]; other site 768492000450 Walker B motif; other site 768492000451 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 768492000452 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 768492000453 Mg++ binding site [ion binding]; other site 768492000454 putative catalytic motif [active] 768492000455 substrate binding site [chemical binding]; other site 768492000456 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 768492000457 Chain length determinant protein; Region: Wzz; cl15801 768492000458 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 768492000459 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 768492000460 active site 768492000461 homodimer interface [polypeptide binding]; other site 768492000462 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 768492000463 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492000464 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 768492000465 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492000466 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 768492000467 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 768492000468 NAD binding site [chemical binding]; other site 768492000469 substrate binding site [chemical binding]; other site 768492000470 homodimer interface [polypeptide binding]; other site 768492000471 active site 768492000472 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 768492000473 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 768492000474 substrate binding site; other site 768492000475 tetramer interface; other site 768492000476 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 768492000477 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 768492000478 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 768492000479 inhibitor-cofactor binding pocket; inhibition site 768492000480 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492000481 catalytic residue [active] 768492000482 MatE; Region: MatE; cl10513 768492000483 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; cl07929 768492000484 WzyE protein; Region: WzyE; cl11643 768492000485 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 768492000486 putative transport protein YifK; Provisional; Region: PRK10746 768492000487 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 768492000488 HemY protein N-terminus; Region: HemY_N; pfam07219 768492000489 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 768492000490 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 768492000491 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 768492000492 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 768492000493 active site 768492000494 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 768492000495 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 768492000496 domain interfaces; other site 768492000497 active site 768492000498 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 768492000499 adenylate cyclase; Provisional; Region: cyaA; PRK09450 768492000500 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 768492000501 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in...; Region: Frataxin; cd00503 768492000502 putative iron binding site [ion binding]; other site 768492000503 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 768492000504 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 768492000505 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 768492000506 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 768492000507 GAF domain; Region: GAF; cl15785 768492000508 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 768492000509 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768492000510 active site 768492000511 DNA binding site [nucleotide binding] 768492000512 Int/Topo IB signature motif; other site 768492000513 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 768492000514 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492000515 motif II; other site 768492000516 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 768492000517 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492000518 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 768492000519 Family description; Region: UvrD_C_2; cl15862 768492000520 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 768492000521 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 768492000522 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 768492000523 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 768492000524 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 768492000525 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 768492000526 EamA-like transporter family; Region: EamA; cl01037 768492000527 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 768492000528 CoenzymeA binding site [chemical binding]; other site 768492000529 subunit interaction site [polypeptide binding]; other site 768492000530 PHB binding site; other site 768492000531 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 768492000532 dimerization interface [polypeptide binding]; other site 768492000533 substrate binding site [chemical binding]; other site 768492000534 active site 768492000535 calcium binding site [ion binding]; other site 768492000536 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 768492000537 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768492000538 ATP binding site [chemical binding]; other site 768492000539 putative Mg++ binding site [ion binding]; other site 768492000540 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768492000541 nucleotide binding region [chemical binding]; other site 768492000542 ATP-binding site [chemical binding]; other site 768492000543 RQC domain; Region: RQC; cl09632 768492000544 HRDC domain; Region: HRDC; cl02578 768492000545 LysE type translocator; Region: LysE; cl00565 768492000546 LysE type translocator; Region: LysE; cl00565 768492000547 lysophospholipase L2; Provisional; Region: PRK10749 768492000548 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 768492000549 putative hydrolase; Provisional; Region: PRK10976 768492000550 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492000551 active site 768492000552 motif I; other site 768492000553 motif II; other site 768492000554 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 768492000555 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 768492000556 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 768492000557 active site 768492000558 catalytic site [active] 768492000559 metal binding site [ion binding]; metal-binding site 768492000560 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 768492000561 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492000562 putative substrate translocation pore; other site 768492000563 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 768492000564 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 768492000565 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 768492000566 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492000567 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 768492000568 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768492000569 Cysteine-rich domain; Region: CCG; pfam02754 768492000570 Cysteine-rich domain; Region: CCG; pfam02754 768492000571 hypothetical protein; Provisional; Region: PRK11615 768492000572 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492000573 Coenzyme A binding pocket [chemical binding]; other site 768492000574 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 768492000575 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 768492000576 CPxP motif; other site 768492000577 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 768492000578 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 768492000579 metal-binding site [ion binding] 768492000580 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768492000581 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 768492000582 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 768492000583 active site 768492000584 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 768492000585 Protease inhibitor Inh; Region: Inh; pfam02974 768492000586 YhhN-like protein; Region: YhhN; cl01505 768492000587 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 768492000588 Protein of unknown function (DUF1145); Region: DUF1145; cl11481 768492000589 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492000590 S-adenosylmethionine binding site [chemical binding]; other site 768492000591 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 768492000592 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 768492000593 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 768492000594 P loop; other site 768492000595 GTP binding site [chemical binding]; other site 768492000596 cell division protein FtsE; Provisional; Region: PRK10908 768492000597 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492000598 Walker A/P-loop; other site 768492000599 ATP binding site [chemical binding]; other site 768492000600 Q-loop/lid; other site 768492000601 ABC transporter signature motif; other site 768492000602 Walker B; other site 768492000603 D-loop; other site 768492000604 H-loop/switch region; other site 768492000605 FtsX-like permease family; Region: FtsX; cl15850 768492000606 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 768492000607 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 768492000608 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768492000609 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768492000610 DNA binding residues [nucleotide binding] 768492000611 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 768492000612 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 768492000613 leucine ABC transporter subunit substrate-binding protein LivK; Provisional; Region: PRK15404 768492000614 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 768492000615 dimerization interface [polypeptide binding]; other site 768492000616 ligand binding site [chemical binding]; other site 768492000617 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 768492000618 TM-ABC transporter signature motif; other site 768492000619 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 768492000620 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 768492000621 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 768492000622 TM-ABC transporter signature motif; other site 768492000623 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 768492000624 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 768492000625 Walker A/P-loop; other site 768492000626 ATP binding site [chemical binding]; other site 768492000627 Q-loop/lid; other site 768492000628 ABC transporter signature motif; other site 768492000629 Walker B; other site 768492000630 D-loop; other site 768492000631 H-loop/switch region; other site 768492000632 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 768492000633 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 768492000634 Walker A/P-loop; other site 768492000635 ATP binding site [chemical binding]; other site 768492000636 Q-loop/lid; other site 768492000637 ABC transporter signature motif; other site 768492000638 Walker B; other site 768492000639 D-loop; other site 768492000640 H-loop/switch region; other site 768492000641 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 768492000642 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492000643 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492000644 homodimer interface [polypeptide binding]; other site 768492000645 catalytic residue [active] 768492000646 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 768492000647 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492000648 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 768492000649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492000650 dimer interface [polypeptide binding]; other site 768492000651 conserved gate region; other site 768492000652 putative PBP binding loops; other site 768492000653 ABC-ATPase subunit interface; other site 768492000654 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 768492000655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492000656 dimer interface [polypeptide binding]; other site 768492000657 conserved gate region; other site 768492000658 putative PBP binding loops; other site 768492000659 ABC-ATPase subunit interface; other site 768492000660 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 768492000661 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 768492000662 Walker A/P-loop; other site 768492000663 ATP binding site [chemical binding]; other site 768492000664 Q-loop/lid; other site 768492000665 ABC transporter signature motif; other site 768492000666 Walker B; other site 768492000667 D-loop; other site 768492000668 H-loop/switch region; other site 768492000669 TOBE domain; Region: TOBE_2; cl01440 768492000670 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 768492000671 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 768492000672 putative active site [active] 768492000673 catalytic site [active] 768492000674 putative metal binding site [ion binding]; other site 768492000675 Membrane transport protein; Region: Mem_trans; cl09117 768492000676 EamA-like transporter family; Region: EamA; cl01037 768492000677 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 768492000678 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 768492000679 Helix-turn-helix domains; Region: HTH; cl00088 768492000680 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 768492000681 putative dimerization interface [polypeptide binding]; other site 768492000682 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 768492000683 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 768492000684 THF binding site; other site 768492000685 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 768492000686 substrate binding site [chemical binding]; other site 768492000687 THF binding site; other site 768492000688 zinc-binding site [ion binding]; other site 768492000689 Dienelactone hydrolase family; Region: DLH; pfam01738 768492000690 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 768492000691 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 768492000692 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 768492000693 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 768492000694 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 768492000695 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 768492000696 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 768492000697 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 768492000698 DNA recombination protein RmuC; Provisional; Region: PRK10361 768492000699 RmuC family; Region: RmuC; pfam02646 768492000700 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 768492000701 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492000702 S-adenosylmethionine binding site [chemical binding]; other site 768492000703 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 768492000704 SCP-2 sterol transfer family; Region: SCP2; cl01225 768492000705 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 768492000706 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 768492000707 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 768492000708 twin arginine translocase protein A; Validated; Region: tatE; PRK01614 768492000709 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 768492000710 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 768492000711 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 768492000712 active site 768492000713 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 768492000714 dimer interface [polypeptide binding]; other site 768492000715 active site 768492000716 aspartate-rich active site metal binding site; other site 768492000717 allosteric magnesium binding site [ion binding]; other site 768492000718 Schiff base residues; other site 768492000719 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 768492000720 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 768492000721 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 768492000722 active site pocket [active] 768492000723 oxyanion hole [active] 768492000724 catalytic triad [active] 768492000725 active site nucleophile [active] 768492000726 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 768492000727 FMN reductase; Validated; Region: fre; PRK08051 768492000728 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 768492000729 FAD binding pocket [chemical binding]; other site 768492000730 FAD binding motif [chemical binding]; other site 768492000731 phosphate binding motif [ion binding]; other site 768492000732 beta-alpha-beta structure motif; other site 768492000733 NAD binding pocket [chemical binding]; other site 768492000734 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 768492000735 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 768492000736 dimer interface [polypeptide binding]; other site 768492000737 active site 768492000738 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 768492000739 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768492000740 substrate binding site [chemical binding]; other site 768492000741 oxyanion hole (OAH) forming residues; other site 768492000742 trimer interface [polypeptide binding]; other site 768492000743 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492000744 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768492000745 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768492000746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492000747 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768492000748 putative substrate translocation pore; other site 768492000749 proline dipeptidase; Provisional; Region: PRK13607 768492000750 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 768492000751 active site 768492000752 hypothetical protein; Provisional; Region: PRK11568 768492000753 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 768492000754 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 768492000755 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 768492000756 Cation transport protein; Region: TrkH; cl10514 768492000757 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 768492000758 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 768492000759 FAD binding domain; Region: FAD_binding_4; pfam01565 768492000760 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 768492000761 Helix-turn-helix domains; Region: HTH; cl00088 768492000762 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 768492000763 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 768492000764 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 768492000765 pantothenate kinase; Provisional; Region: PRK05439 768492000766 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 768492000767 ATP-binding site [chemical binding]; other site 768492000768 CoA-binding site [chemical binding]; other site 768492000769 Mg2+-binding site [ion binding]; other site 768492000770 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768492000771 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492000772 Coenzyme A binding pocket [chemical binding]; other site 768492000773 elongation factor Tu; Reviewed; Region: PRK00049 768492000774 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 768492000775 G1 box; other site 768492000776 GEF interaction site [polypeptide binding]; other site 768492000777 GTP/Mg2+ binding site [chemical binding]; other site 768492000778 Switch I region; other site 768492000779 G2 box; other site 768492000780 G3 box; other site 768492000781 Switch II region; other site 768492000782 G4 box; other site 768492000783 G5 box; other site 768492000784 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 768492000785 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 768492000786 Antibiotic Binding Site [chemical binding]; other site 768492000787 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 768492000788 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 768492000789 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 768492000790 putative homodimer interface [polypeptide binding]; other site 768492000791 KOW motif; Region: KOW; cl00354 768492000792 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 768492000793 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 768492000794 23S rRNA interface [nucleotide binding]; other site 768492000795 L7/L12 interface [polypeptide binding]; other site 768492000796 putative thiostrepton binding site; other site 768492000797 L25 interface [polypeptide binding]; other site 768492000798 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 768492000799 mRNA/rRNA interface [nucleotide binding]; other site 768492000800 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 768492000801 23S rRNA interface [nucleotide binding]; other site 768492000802 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 768492000803 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 768492000804 core dimer interface [polypeptide binding]; other site 768492000805 peripheral dimer interface [polypeptide binding]; other site 768492000806 L10 interface [polypeptide binding]; other site 768492000807 L11 interface [polypeptide binding]; other site 768492000808 putative EF-Tu interaction site [polypeptide binding]; other site 768492000809 putative EF-G interaction site [polypeptide binding]; other site 768492000810 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 768492000811 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 768492000812 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 768492000813 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 768492000814 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 768492000815 RPB11 interaction site [polypeptide binding]; other site 768492000816 RPB12 interaction site [polypeptide binding]; other site 768492000817 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 768492000818 RPB3 interaction site [polypeptide binding]; other site 768492000819 RPB1 interaction site [polypeptide binding]; other site 768492000820 RPB11 interaction site [polypeptide binding]; other site 768492000821 RPB10 interaction site [polypeptide binding]; other site 768492000822 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 768492000823 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 768492000824 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 768492000825 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 768492000826 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 768492000827 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 768492000828 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 768492000829 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 768492000830 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 768492000831 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 768492000832 DNA binding site [nucleotide binding] 768492000833 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 768492000834 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768492000835 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492000836 Coenzyme A binding pocket [chemical binding]; other site 768492000837 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 768492000838 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768492000839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492000840 ATP binding site [chemical binding]; other site 768492000841 Mg2+ binding site [ion binding]; other site 768492000842 G-X-G motif; other site 768492000843 BetR domain; Region: BetR; pfam08667 768492000844 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 768492000845 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 768492000846 active site 768492000847 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 768492000848 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768492000849 FeS/SAM binding site; other site 768492000850 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 768492000851 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 768492000852 ThiS interaction site; other site 768492000853 putative active site [active] 768492000854 tetramer interface [polypeptide binding]; other site 768492000855 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 768492000856 thiS-thiF/thiG interaction site; other site 768492000857 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 768492000858 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 768492000859 ATP binding site [chemical binding]; other site 768492000860 substrate interface [chemical binding]; other site 768492000861 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 768492000862 thiamine phosphate binding site [chemical binding]; other site 768492000863 active site 768492000864 pyrophosphate binding site [ion binding]; other site 768492000865 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 768492000866 ThiC-associated domain; Region: ThiC-associated; pfam13667 768492000867 ThiC family; Region: ThiC; cl08031 768492000868 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ; Region: Rsd_AlgQ; cl11478 768492000869 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 768492000870 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 768492000871 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 768492000872 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 768492000873 putative NADH binding site [chemical binding]; other site 768492000874 putative active site [active] 768492000875 nudix motif; other site 768492000876 putative metal binding site [ion binding]; other site 768492000877 methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463 768492000878 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 768492000879 substrate binding site [chemical binding]; other site 768492000880 active site 768492000881 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 768492000882 Active_site [active] 768492000883 Protein of unknown function (DUF416); Region: DUF416; cl01166 768492000884 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 768492000885 IHF dimer interface [polypeptide binding]; other site 768492000886 IHF - DNA interface [nucleotide binding]; other site 768492000887 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 768492000888 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 768492000889 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 768492000890 ATP-grasp domain; Region: ATP-grasp_4; cl03087 768492000891 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 768492000892 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 768492000893 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 768492000894 purine monophosphate binding site [chemical binding]; other site 768492000895 dimer interface [polypeptide binding]; other site 768492000896 putative catalytic residues [active] 768492000897 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 768492000898 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 768492000899 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 768492000900 Sodium:solute symporter family; Region: SSF; cl00456 768492000901 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 768492000902 Protein of unknown function, DUF485; Region: DUF485; cl01231 768492000903 acetyl-CoA synthetase; Provisional; Region: PRK00174 768492000904 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 768492000905 AMP-binding enzyme; Region: AMP-binding; cl15778 768492000906 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 768492000907 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 768492000908 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 768492000909 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 768492000910 active site clefts [active] 768492000911 zinc binding site [ion binding]; other site 768492000912 dimer interface [polypeptide binding]; other site 768492000913 Sulfate transporter family; Region: Sulfate_transp; cl15842 768492000914 Sulfate transporter family; Region: Sulfate_transp; cl15842 768492000915 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 768492000916 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 768492000917 P-loop; other site 768492000918 Magnesium ion binding site [ion binding]; other site 768492000919 replicative DNA helicase; Region: DnaB; TIGR00665 768492000920 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 768492000921 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 768492000922 Walker A motif; other site 768492000923 ATP binding site [chemical binding]; other site 768492000924 Walker B motif; other site 768492000925 DNA binding loops [nucleotide binding] 768492000926 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 768492000927 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 768492000928 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 768492000929 Domain of unknown function (DUF1845); Region: DUF1845; cl07481 768492000930 DNA topoisomerase III; Provisional; Region: PRK07726 768492000931 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 768492000932 active site 768492000933 putative interdomain interaction site [polypeptide binding]; other site 768492000934 putative metal-binding site [ion binding]; other site 768492000935 putative nucleotide binding site [chemical binding]; other site 768492000936 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 768492000937 domain I; other site 768492000938 DNA binding groove [nucleotide binding] 768492000939 phosphate binding site [ion binding]; other site 768492000940 domain II; other site 768492000941 domain III; other site 768492000942 nucleotide binding site [chemical binding]; other site 768492000943 catalytic site [active] 768492000944 domain IV; other site 768492000945 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 768492000946 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 768492000947 substrate binding pocket [chemical binding]; other site 768492000948 active site 768492000949 iron coordination sites [ion binding]; other site 768492000950 Domain of unknown function (DUF955); Region: DUF955; cl01076 768492000951 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 768492000952 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492000953 Family description; Region: UvrD_C_2; cl15862 768492000954 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 768492000955 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 768492000956 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 768492000957 Protein of unknown function (DUF2859); Region: DUF2859; cl12633 768492000958 Restriction endonuclease; Region: Mrr_cat; cl00516 768492000959 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 768492000960 Domain of unknown function DUF87; Region: DUF87; pfam01935 768492000961 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 768492000962 Domain of unknown function (DUF4400); Region: DUF4400; cl14023 768492000963 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 768492000964 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 768492000965 Protein of unknown function (DUF3262); Region: DUF3262; cl13160 768492000966 Protein of unknown function (DUF2976); Region: DUF2976; cl12739 768492000967 Protein of unknown function (DUF3487); Region: DUF3487; cl13432 768492000968 Protein of unknown function (DUF2895); Region: DUF2895; cl12968 768492000969 Protein of unknown function (DUF3438); Region: DUF3438; cl13372 768492000970 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 768492000971 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 768492000972 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 768492000973 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 768492000974 Protein of unknown function (DUF1525); Region: DUF1525; cl06515 768492000975 TraU protein; Region: TraU; cl06067 768492000976 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 768492000977 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 768492000978 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768492000979 AAA ATPase domain; Region: AAA_15; pfam13175 768492000980 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492000981 Walker A/P-loop; other site 768492000982 ATP binding site [chemical binding]; other site 768492000983 AAA ATPase domain; Region: AAA_15; pfam13175 768492000984 RES domain; Region: RES; cl02411 768492000985 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768492000986 active site 768492000987 Int/Topo IB signature motif; other site 768492000988 DNA binding site [nucleotide binding] 768492000989 Protein of unknown function (DUF3085); Region: DUF3085; pfam11284 768492000990 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 768492000991 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 768492000992 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 768492000993 HlyD family secretion protein; Region: HlyD; pfam00529 768492000994 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 768492000995 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 768492000996 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 768492000997 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39C; cd02419 768492000998 putative active site [active] 768492000999 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 768492001000 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492001001 Walker A/P-loop; other site 768492001002 ATP binding site [chemical binding]; other site 768492001003 Q-loop/lid; other site 768492001004 ABC transporter signature motif; other site 768492001005 Walker B; other site 768492001006 D-loop; other site 768492001007 H-loop/switch region; other site 768492001008 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 768492001009 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492001010 ATP binding site [chemical binding]; other site 768492001011 Mg2+ binding site [ion binding]; other site 768492001012 G-X-G motif; other site 768492001013 Response regulator receiver domain; Region: Response_reg; pfam00072 768492001014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492001015 active site 768492001016 phosphorylation site [posttranslational modification] 768492001017 intermolecular recognition site; other site 768492001018 dimerization interface [polypeptide binding]; other site 768492001019 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 768492001020 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 768492001021 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 768492001022 BetR domain; Region: BetR; pfam08667 768492001023 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 768492001024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492001025 active site 768492001026 phosphorylation site [posttranslational modification] 768492001027 intermolecular recognition site; other site 768492001028 dimerization interface [polypeptide binding]; other site 768492001029 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 768492001030 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 768492001031 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 768492001032 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 768492001033 active site 768492001034 catalytic residues [active] 768492001035 DNA binding site [nucleotide binding] 768492001036 Int/Topo IB signature motif; other site 768492001037 putative transcriptional regulator; Provisional; Region: PRK11640 768492001038 Helix-turn-helix domains; Region: HTH; cl00088 768492001039 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 768492001040 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 768492001041 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 768492001042 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 768492001043 DsbD alpha interface [polypeptide binding]; other site 768492001044 catalytic residues [active] 768492001045 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 768492001046 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 768492001047 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 768492001048 Aspartase; Region: Aspartase; cd01357 768492001049 active sites [active] 768492001050 tetramer interface [polypeptide binding]; other site 768492001051 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 768492001052 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 768492001053 oligomerisation interface [polypeptide binding]; other site 768492001054 mobile loop; other site 768492001055 roof hairpin; other site 768492001056 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 768492001057 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 768492001058 ring oligomerisation interface [polypeptide binding]; other site 768492001059 ATP/Mg binding site [chemical binding]; other site 768492001060 stacking interactions; other site 768492001061 hinge regions; other site 768492001062 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 768492001063 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 768492001064 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768492001065 FeS/SAM binding site; other site 768492001066 elongation factor P; Validated; Region: PRK00529 768492001067 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 768492001068 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 768492001069 RNA binding site [nucleotide binding]; other site 768492001070 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 768492001071 RNA binding site [nucleotide binding]; other site 768492001072 Entericidin EcnA/B family; Region: Entericidin; cl02322 768492001073 Entericidin EcnA/B family; Region: Entericidin; cl02322 768492001074 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 768492001075 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 768492001076 Iron-sulfur protein interface; other site 768492001077 proximal quinone binding site [chemical binding]; other site 768492001078 C-subunit interface; other site 768492001079 distal quinone binding site; other site 768492001080 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 768492001081 D-subunit interface [polypeptide binding]; other site 768492001082 Iron-sulfur protein interface; other site 768492001083 proximal quinone binding site [chemical binding]; other site 768492001084 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 768492001085 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 768492001086 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 768492001087 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492001088 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 768492001089 poxB regulator PoxA; Provisional; Region: PRK09350 768492001090 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 768492001091 motif 1; other site 768492001092 dimer interface [polypeptide binding]; other site 768492001093 active site 768492001094 motif 2; other site 768492001095 motif 3; other site 768492001096 putative mechanosensitive channel protein; Provisional; Region: PRK10929 768492001097 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 768492001098 Mechanosensitive ion channel; Region: MS_channel; pfam00924 768492001099 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 768492001100 GTPase RsgA; Reviewed; Region: PRK12288 768492001101 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 768492001102 RNA binding site [nucleotide binding]; other site 768492001103 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 768492001104 GTPase/Zn-binding domain interface [polypeptide binding]; other site 768492001105 GTP/Mg2+ binding site [chemical binding]; other site 768492001106 G4 box; other site 768492001107 G5 box; other site 768492001108 G1 box; other site 768492001109 Switch I region; other site 768492001110 G2 box; other site 768492001111 G3 box; other site 768492001112 Switch II region; other site 768492001113 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 768492001114 catalytic site [active] 768492001115 putative active site [active] 768492001116 putative substrate binding site [chemical binding]; other site 768492001117 dimer interface [polypeptide binding]; other site 768492001118 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 768492001119 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 768492001120 putative carbohydrate kinase; Provisional; Region: PRK10565 768492001121 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 768492001122 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 768492001123 putative substrate binding site [chemical binding]; other site 768492001124 putative ATP binding site [chemical binding]; other site 768492001125 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 768492001126 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 768492001127 AMIN domain; Region: AMIN; pfam11741 768492001128 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 768492001129 active site 768492001130 metal binding site [ion binding]; metal-binding site 768492001131 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 768492001132 putative peptidoglycan binding site; other site 768492001133 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 768492001134 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492001135 ATP binding site [chemical binding]; other site 768492001136 Mg2+ binding site [ion binding]; other site 768492001137 G-X-G motif; other site 768492001138 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 768492001139 ATP binding site [chemical binding]; other site 768492001140 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 768492001141 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492001142 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 768492001143 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 768492001144 Sm1 motif; other site 768492001145 intra - hexamer interaction site; other site 768492001146 inter - hexamer interaction site [polypeptide binding]; other site 768492001147 nucleotide binding pocket [chemical binding]; other site 768492001148 Sm2 motif; other site 768492001149 GTPase HflX; Provisional; Region: PRK11058 768492001150 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 768492001151 HflX GTPase family; Region: HflX; cd01878 768492001152 G1 box; other site 768492001153 GTP/Mg2+ binding site [chemical binding]; other site 768492001154 Switch I region; other site 768492001155 G2 box; other site 768492001156 G3 box; other site 768492001157 Switch II region; other site 768492001158 G4 box; other site 768492001159 G5 box; other site 768492001160 FtsH protease regulator HflK; Provisional; Region: PRK10930 768492001161 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 768492001162 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 768492001163 FtsH protease regulator HflC; Provisional; Region: PRK11029 768492001164 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 768492001165 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; cl01275 768492001166 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 768492001167 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 768492001168 GDP-binding site [chemical binding]; other site 768492001169 ACT binding site; other site 768492001170 IMP binding site; other site 768492001171 Helix-turn-helix domains; Region: HTH; cl00088 768492001172 Rrf2 family protein; Region: rrf2_super; TIGR00738 768492001173 exoribonuclease R; Provisional; Region: PRK11642 768492001174 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 768492001175 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 768492001176 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 768492001177 RNB domain; Region: RNB; pfam00773 768492001178 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 768492001179 RNA binding site [nucleotide binding]; other site 768492001180 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 768492001181 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 768492001182 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 768492001183 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 768492001184 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 768492001185 FAD binding site [chemical binding]; other site 768492001186 substrate binding site [chemical binding]; other site 768492001187 catalytic residues [active] 768492001188 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 768492001189 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 768492001190 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 768492001191 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 768492001192 esterase; Provisional; Region: PRK10566 768492001193 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 768492001194 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 768492001195 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 768492001196 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 768492001197 dimer interface [polypeptide binding]; other site 768492001198 ssDNA binding site [nucleotide binding]; other site 768492001199 tetramer (dimer of dimers) interface [polypeptide binding]; other site 768492001200 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 768492001201 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 768492001202 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 768492001203 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 768492001204 Protein of unknown function, DUF488; Region: DUF488; cl01246 768492001205 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 768492001206 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 768492001207 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 768492001208 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 768492001209 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 768492001210 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 768492001211 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 768492001212 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 768492001213 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 768492001214 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 768492001215 active site 768492001216 metal binding site [ion binding]; metal-binding site 768492001217 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 768492001218 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 768492001219 active site 768492001220 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl01158 768492001221 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 768492001222 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 768492001223 Domain of unknown function DUF21; Region: DUF21; pfam01595 768492001224 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 768492001225 Transporter associated domain; Region: CorC_HlyC; cl08393 768492001226 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 768492001227 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 768492001228 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 768492001229 Surface antigen; Region: Bac_surface_Ag; cl03097 768492001230 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 768492001231 AsmA-like C-terminal region; Region: AsmA_2; cl15864 768492001232 Family of unknown function (DUF490); Region: DUF490; pfam04357 768492001233 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 768492001234 putative active site pocket [active] 768492001235 dimerization interface [polypeptide binding]; other site 768492001236 putative catalytic residue [active] 768492001237 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 768492001238 dimer interface [polypeptide binding]; other site 768492001239 substrate binding site [chemical binding]; other site 768492001240 metal binding sites [ion binding]; metal-binding site 768492001241 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 768492001242 ligand binding site [chemical binding]; other site 768492001243 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 768492001244 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768492001245 dimerization interface [polypeptide binding]; other site 768492001246 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768492001247 dimer interface [polypeptide binding]; other site 768492001248 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 768492001249 putative CheW interface [polypeptide binding]; other site 768492001250 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 768492001251 AMP binding site [chemical binding]; other site 768492001252 metal binding site [ion binding]; metal-binding site 768492001253 active site 768492001254 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 768492001255 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 768492001256 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768492001257 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768492001258 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 768492001259 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 768492001260 arginine repressor; Provisional; Region: PRK05066 768492001261 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 768492001262 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 768492001263 malate dehydrogenase; Provisional; Region: PRK05086 768492001264 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 768492001265 NAD binding site [chemical binding]; other site 768492001266 dimerization interface [polypeptide binding]; other site 768492001267 Substrate binding site [chemical binding]; other site 768492001268 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 768492001269 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 768492001270 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 768492001271 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 768492001272 substrate binding pocket [chemical binding]; other site 768492001273 chain length determination region; other site 768492001274 substrate-Mg2+ binding site; other site 768492001275 catalytic residues [active] 768492001276 aspartate-rich region 1; other site 768492001277 active site lid residues [active] 768492001278 aspartate-rich region 2; other site 768492001279 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 768492001280 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 768492001281 EamA-like transporter family; Region: EamA; cl01037 768492001282 GTPase CgtA; Reviewed; Region: obgE; PRK12298 768492001283 GTP1/OBG; Region: GTP1_OBG; pfam01018 768492001284 Obg GTPase; Region: Obg; cd01898 768492001285 G1 box; other site 768492001286 GTP/Mg2+ binding site [chemical binding]; other site 768492001287 Switch I region; other site 768492001288 G2 box; other site 768492001289 G3 box; other site 768492001290 Switch II region; other site 768492001291 G4 box; other site 768492001292 G5 box; other site 768492001293 sensor protein BasS/PmrB; Provisional; Region: PRK10755 768492001294 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 768492001295 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492001296 dimer interface [polypeptide binding]; other site 768492001297 phosphorylation site [posttranslational modification] 768492001298 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492001299 ATP binding site [chemical binding]; other site 768492001300 Mg2+ binding site [ion binding]; other site 768492001301 G-X-G motif; other site 768492001302 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 768492001303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492001304 active site 768492001305 phosphorylation site [posttranslational modification] 768492001306 intermolecular recognition site; other site 768492001307 dimerization interface [polypeptide binding]; other site 768492001308 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768492001309 DNA binding site [nucleotide binding] 768492001310 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 768492001311 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 768492001312 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 768492001313 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 768492001314 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 768492001315 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 768492001316 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 768492001317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492001318 S-adenosylmethionine binding site [chemical binding]; other site 768492001319 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 768492001320 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492001321 Walker A motif; other site 768492001322 ATP binding site [chemical binding]; other site 768492001323 Walker B motif; other site 768492001324 arginine finger; other site 768492001325 Peptidase family M41; Region: Peptidase_M41; pfam01434 768492001326 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 768492001327 dihydropteroate synthase; Region: DHPS; TIGR01496 768492001328 substrate binding pocket [chemical binding]; other site 768492001329 dimer interface [polypeptide binding]; other site 768492001330 inhibitor binding site; inhibition site 768492001331 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 768492001332 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 768492001333 active site 768492001334 substrate binding site [chemical binding]; other site 768492001335 metal binding site [ion binding]; metal-binding site 768492001336 Preprotein translocase SecG subunit; Region: SecG; cl09123 768492001337 ribosome maturation protein RimP; Reviewed; Region: PRK00092 768492001338 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 768492001339 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 768492001340 Sm1 motif; other site 768492001341 predicted subunit interaction site [polypeptide binding]; other site 768492001342 RNA binding pocket [nucleotide binding]; other site 768492001343 Sm2 motif; other site 768492001344 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 768492001345 NusA N-terminal domain; Region: NusA_N; pfam08529 768492001346 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 768492001347 RNA binding site [nucleotide binding]; other site 768492001348 homodimer interface [polypeptide binding]; other site 768492001349 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 768492001350 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 768492001351 G-X-X-G motif; other site 768492001352 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 768492001353 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 768492001354 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 768492001355 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 768492001356 translation initiation factor IF-2; Region: IF-2; TIGR00487 768492001357 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 768492001358 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 768492001359 G1 box; other site 768492001360 putative GEF interaction site [polypeptide binding]; other site 768492001361 GTP/Mg2+ binding site [chemical binding]; other site 768492001362 Switch I region; other site 768492001363 G2 box; other site 768492001364 G3 box; other site 768492001365 Switch II region; other site 768492001366 G4 box; other site 768492001367 G5 box; other site 768492001368 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 768492001369 Translation-initiation factor 2; Region: IF-2; pfam11987 768492001370 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 768492001371 Ribosome-binding factor A; Region: RBFA; cl00542 768492001372 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 768492001373 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 768492001374 RNA binding site [nucleotide binding]; other site 768492001375 active site 768492001376 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 768492001377 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 768492001378 16S/18S rRNA binding site [nucleotide binding]; other site 768492001379 S13e-L30e interaction site [polypeptide binding]; other site 768492001380 25S rRNA binding site [nucleotide binding]; other site 768492001381 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 768492001382 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 768492001383 RNase E interface [polypeptide binding]; other site 768492001384 trimer interface [polypeptide binding]; other site 768492001385 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 768492001386 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 768492001387 RNase E interface [polypeptide binding]; other site 768492001388 trimer interface [polypeptide binding]; other site 768492001389 active site 768492001390 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 768492001391 putative nucleic acid binding region [nucleotide binding]; other site 768492001392 G-X-X-G motif; other site 768492001393 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 768492001394 RNA binding site [nucleotide binding]; other site 768492001395 domain interface; other site 768492001396 lipoprotein NlpI; Provisional; Region: PRK11189 768492001397 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768492001398 binding surface 768492001399 TPR motif; other site 768492001400 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 768492001401 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 768492001402 ATP binding site [chemical binding]; other site 768492001403 Mg++ binding site [ion binding]; other site 768492001404 motif III; other site 768492001405 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768492001406 nucleotide binding region [chemical binding]; other site 768492001407 ATP-binding site [chemical binding]; other site 768492001408 DbpA RNA binding domain; Region: DbpA; pfam03880 768492001409 putative inner membrane protein; Provisional; Region: PRK11099 768492001410 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 768492001411 CPxP motif; other site 768492001412 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 768492001413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492001414 putative substrate translocation pore; other site 768492001415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492001416 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 768492001417 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 768492001418 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 768492001419 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 768492001420 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 768492001421 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 768492001422 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 768492001423 ABC-2 type transporter; Region: ABC2_membrane; cl11417 768492001424 ABC-2 type transporter; Region: ABC2_membrane; cl11417 768492001425 Helix-turn-helix domains; Region: HTH; cl00088 768492001426 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 768492001427 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 768492001428 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 768492001429 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 768492001430 active site 768492001431 Peptidase family U32; Region: Peptidase_U32; cl03113 768492001432 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 768492001433 Peptidase family U32; Region: Peptidase_U32; cl03113 768492001434 SCP-2 sterol transfer family; Region: SCP2; cl01225 768492001435 Predicted acetyltransferase [General function prediction only]; Region: COG3153 768492001436 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 768492001437 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 768492001438 GIY-YIG motif/motif A; other site 768492001439 putative active site [active] 768492001440 putative metal binding site [ion binding]; other site 768492001441 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 768492001442 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 768492001443 NADH(P)-binding; Region: NAD_binding_10; pfam13460 768492001444 NAD binding site [chemical binding]; other site 768492001445 active site 768492001446 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 768492001447 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 768492001448 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 768492001449 trimer interface [polypeptide binding]; other site 768492001450 active site 768492001451 substrate binding site [chemical binding]; other site 768492001452 CoA binding site [chemical binding]; other site 768492001453 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492001454 AAA domain; Region: AAA_18; pfam13238 768492001455 active site 768492001456 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 768492001457 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 768492001458 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 768492001459 active site 768492001460 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 768492001461 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 768492001462 Walker A/P-loop; other site 768492001463 ATP binding site [chemical binding]; other site 768492001464 Q-loop/lid; other site 768492001465 ABC transporter signature motif; other site 768492001466 Walker B; other site 768492001467 D-loop; other site 768492001468 H-loop/switch region; other site 768492001469 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 768492001470 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 768492001471 Walker A/P-loop; other site 768492001472 ATP binding site [chemical binding]; other site 768492001473 Q-loop/lid; other site 768492001474 ABC transporter signature motif; other site 768492001475 Walker B; other site 768492001476 D-loop; other site 768492001477 H-loop/switch region; other site 768492001478 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768492001479 Phosphonate metabolism protein PhnJ; Region: PhnJ; cl01457 768492001480 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; cl01456 768492001481 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; cl01455 768492001482 Phosphonate metabolism protein PhnG; Region: PhnG; cl01454 768492001483 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 768492001484 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492001485 DNA-binding site [nucleotide binding]; DNA binding site 768492001486 UTRA domain; Region: UTRA; cl01230 768492001487 Predicted permease; Region: DUF318; pfam03773 768492001488 Predicted permeases [General function prediction only]; Region: COG0701 768492001489 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 768492001490 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 768492001491 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 768492001492 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 768492001493 ATP cone domain; Region: ATP-cone; pfam03477 768492001494 Class III ribonucleotide reductase; Region: RNR_III; cd01675 768492001495 effector binding site; other site 768492001496 active site 768492001497 Zn binding site [ion binding]; other site 768492001498 glycine loop; other site 768492001499 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492001500 Helix-turn-helix domains; Region: HTH; cl00088 768492001501 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492001502 putative effector binding pocket; other site 768492001503 dimerization interface [polypeptide binding]; other site 768492001504 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 768492001505 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 768492001506 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 768492001507 Ca binding site [ion binding]; other site 768492001508 active site 768492001509 catalytic site [active] 768492001510 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 768492001511 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 768492001512 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768492001513 active site turn [active] 768492001514 phosphorylation site [posttranslational modification] 768492001515 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 768492001516 trehalose repressor; Provisional; Region: treR; PRK09492 768492001517 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492001518 DNA binding site [nucleotide binding] 768492001519 domain linker motif; other site 768492001520 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 768492001521 dimerization interface [polypeptide binding]; other site 768492001522 ligand binding site [chemical binding]; other site 768492001523 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 768492001524 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 768492001525 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768492001526 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 768492001527 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 768492001528 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 768492001529 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 768492001530 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 768492001531 active site 768492001532 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 768492001533 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 768492001534 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 768492001535 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 768492001536 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 768492001537 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 768492001538 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 768492001539 Uncharacterized conserved protein [Function unknown]; Region: COG2308 768492001540 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174 768492001541 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 768492001542 homotrimer interaction site [polypeptide binding]; other site 768492001543 putative active site [active] 768492001544 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 768492001545 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 768492001546 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 768492001547 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 768492001548 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 768492001549 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492001550 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 768492001551 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 768492001552 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 768492001553 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 768492001554 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492001555 RNase E inhibitor protein; Provisional; Region: PRK11191 768492001556 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 768492001557 active site 768492001558 dinuclear metal binding site [ion binding]; other site 768492001559 dimerization interface [polypeptide binding]; other site 768492001560 choline dehydrogenase; Validated; Region: PRK02106 768492001561 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492001562 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 768492001563 Acyltransferase family; Region: Acyl_transf_3; pfam01757 768492001564 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768492001565 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492001566 Coenzyme A binding pocket [chemical binding]; other site 768492001567 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 768492001568 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 768492001569 HIGH motif; other site 768492001570 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 768492001571 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 768492001572 active site 768492001573 KMSKS motif; other site 768492001574 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 768492001575 tRNA binding surface [nucleotide binding]; other site 768492001576 anticodon binding site; other site 768492001577 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 768492001578 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 768492001579 multifunctional aminopeptidase A; Provisional; Region: PRK00913 768492001580 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 768492001581 interface (dimer of trimers) [polypeptide binding]; other site 768492001582 Substrate-binding/catalytic site; other site 768492001583 Zn-binding sites [ion binding]; other site 768492001584 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 768492001585 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 768492001586 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 768492001587 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 768492001588 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 768492001589 active site clefts [active] 768492001590 zinc binding site [ion binding]; other site 768492001591 dimer interface [polypeptide binding]; other site 768492001592 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 768492001593 HipA N-terminal domain; Region: Couple_hipA; cl11853 768492001594 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 768492001595 HipA-like N-terminal domain; Region: HipA_N; pfam07805 768492001596 HipA-like C-terminal domain; Region: HipA_C; pfam07804 768492001597 Z1 domain; Region: Z1; pfam10593 768492001598 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 768492001599 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 768492001600 DNA binding site [nucleotide binding] 768492001601 substrate interaction site [chemical binding]; other site 768492001602 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 768492001603 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 768492001604 additional DNA contacts [nucleotide binding]; other site 768492001605 mismatch recognition site; other site 768492001606 active site 768492001607 zinc binding site [ion binding]; other site 768492001608 DNA intercalation site [nucleotide binding]; other site 768492001609 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 768492001610 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 768492001611 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768492001612 active site turn [active] 768492001613 phosphorylation site [posttranslational modification] 768492001614 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 768492001615 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768492001616 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492001617 DNA binding site [nucleotide binding] 768492001618 domain linker motif; other site 768492001619 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 768492001620 dimerization interface (closed form) [polypeptide binding]; other site 768492001621 ligand binding site [chemical binding]; other site 768492001622 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 768492001623 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 768492001624 P-loop, Walker A motif; other site 768492001625 Base recognition motif; other site 768492001626 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 768492001627 Protein of unknown function (DUF466); Region: DUF466; cl01082 768492001628 carbon starvation protein A; Provisional; Region: PRK15015 768492001629 Carbon starvation protein CstA; Region: CstA; pfam02554 768492001630 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 768492001631 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 768492001632 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 768492001633 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 768492001634 active site 768492001635 dimer interface [polypeptide binding]; other site 768492001636 non-prolyl cis peptide bond; other site 768492001637 insertion regions; other site 768492001638 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 768492001639 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 768492001640 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492001641 Coenzyme A binding pocket [chemical binding]; other site 768492001642 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 768492001643 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 768492001644 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 768492001645 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492001646 non-specific DNA binding site [nucleotide binding]; other site 768492001647 salt bridge; other site 768492001648 sequence-specific DNA binding site [nucleotide binding]; other site 768492001649 Uncharacterized conserved protein [Function unknown]; Region: COG3391 768492001650 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 768492001651 putative transporter; Provisional; Region: PRK11043 768492001652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492001653 putative substrate translocation pore; other site 768492001654 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 768492001655 Phosphopantetheine attachment site; Region: PP-binding; cl09936 768492001656 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 768492001657 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 768492001658 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 768492001659 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 768492001660 active site 768492001661 acyl-CoA synthetase; Validated; Region: PRK05850 768492001662 AMP-binding enzyme; Region: AMP-binding; cl15778 768492001663 peptide synthase; Provisional; Region: PRK12467 768492001664 Phosphopantetheine attachment site; Region: PP-binding; cl09936 768492001665 thioester reductase domain; Region: Thioester-redct; TIGR01746 768492001666 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 768492001667 putative NAD(P) binding site [chemical binding]; other site 768492001668 active site 768492001669 putative substrate binding site [chemical binding]; other site 768492001670 peptide synthase; Provisional; Region: PRK12467 768492001671 AMP-binding enzyme; Region: AMP-binding; cl15778 768492001672 Phosphopantetheine attachment site; Region: PP-binding; cl09936 768492001673 AMP-binding enzyme; Region: AMP-binding; cl15778 768492001674 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 768492001675 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 768492001676 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 768492001677 AMP-binding enzyme; Region: AMP-binding; cl15778 768492001678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492001679 S-adenosylmethionine binding site [chemical binding]; other site 768492001680 Cupin domain; Region: Cupin_2; cl09118 768492001681 Helix-turn-helix domain; Region: HTH_18; pfam12833 768492001682 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 768492001683 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492001684 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 768492001685 L,D-transpeptidase; Provisional; Region: PRK10260 768492001686 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 768492001687 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 768492001688 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 768492001689 Gram-negative bacterial tonB protein; Region: TonB; cl10048 768492001690 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 768492001691 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 768492001692 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 768492001693 Putative catalytic domain, repeat 1, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_1; cd09106 768492001694 PLD-like domain; Region: PLDc_2; pfam13091 768492001695 putative active site [active] 768492001696 putative catalytic site [active] 768492001697 Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_2; cd09107 768492001698 putative active site [active] 768492001699 putative catalytic site [active] 768492001700 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 768492001701 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768492001702 inhibitor-cofactor binding pocket; inhibition site 768492001703 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492001704 catalytic residue [active] 768492001705 Helix-turn-helix domains; Region: HTH; cl00088 768492001706 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768492001707 dimerization interface [polypeptide binding]; other site 768492001708 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 768492001709 active site 768492001710 NAD binding site [chemical binding]; other site 768492001711 metal binding site [ion binding]; metal-binding site 768492001712 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492001713 DNA binding residues [nucleotide binding] 768492001714 dimerization interface [polypeptide binding]; other site 768492001715 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 768492001716 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492001717 Cupin domain; Region: Cupin_2; cl09118 768492001718 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 768492001719 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 768492001720 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 768492001721 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 768492001722 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 768492001723 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 768492001724 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768492001725 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768492001726 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492001727 DNA binding residues [nucleotide binding] 768492001728 dimerization interface [polypeptide binding]; other site 768492001729 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 768492001730 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 768492001731 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 768492001732 classical (c) SDRs; Region: SDR_c; cd05233 768492001733 NAD(P) binding site [chemical binding]; other site 768492001734 active site 768492001735 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 768492001736 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 768492001737 classical (c) SDRs; Region: SDR_c; cd05233 768492001738 NAD(P) binding site [chemical binding]; other site 768492001739 active site 768492001740 Helix-turn-helix domains; Region: HTH; cl00088 768492001741 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768492001742 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 768492001743 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 768492001744 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 768492001745 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 768492001746 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 768492001747 NAD binding site [chemical binding]; other site 768492001748 catalytic residues [active] 768492001749 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 768492001750 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 768492001751 tetramer interface [polypeptide binding]; other site 768492001752 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 768492001753 tetramer interface [polypeptide binding]; other site 768492001754 active site 768492001755 metal binding site [ion binding]; metal-binding site 768492001756 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 768492001757 putative substrate binding pocket [chemical binding]; other site 768492001758 trimer interface [polypeptide binding]; other site 768492001759 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 768492001760 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 768492001761 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 768492001762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492001763 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 768492001764 putative substrate translocation pore; other site 768492001765 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 768492001766 Cupin domain; Region: Cupin_2; cl09118 768492001767 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 768492001768 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 768492001769 Flavin Reductases; Region: FlaRed; cl00801 768492001770 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 768492001771 Transcriptional regulators [Transcription]; Region: FadR; COG2186 768492001772 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492001773 DNA-binding site [nucleotide binding]; DNA binding site 768492001774 FCD domain; Region: FCD; cl11656 768492001775 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 768492001776 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 768492001777 NAD binding site [chemical binding]; other site 768492001778 homotetramer interface [polypeptide binding]; other site 768492001779 homodimer interface [polypeptide binding]; other site 768492001780 active site 768492001781 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 768492001782 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 768492001783 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 768492001784 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 768492001785 putative active site pocket [active] 768492001786 metal binding site [ion binding]; metal-binding site 768492001787 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 768492001788 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 768492001789 short chain dehydrogenase; Provisional; Region: PRK08628 768492001790 classical (c) SDRs; Region: SDR_c; cd05233 768492001791 NAD(P) binding site [chemical binding]; other site 768492001792 active site 768492001793 Domain of unknown function (DUF718); Region: DUF718; cl01281 768492001794 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 768492001795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492001796 putative substrate translocation pore; other site 768492001797 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768492001798 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492001799 putative substrate translocation pore; other site 768492001800 LysR family transcriptional regulator; Provisional; Region: PRK14997 768492001801 Helix-turn-helix domains; Region: HTH; cl00088 768492001802 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492001803 putative effector binding pocket; other site 768492001804 dimerization interface [polypeptide binding]; other site 768492001805 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768492001806 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492001807 Helix-turn-helix domains; Region: HTH; cl00088 768492001808 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768492001809 metal binding site [ion binding]; metal-binding site 768492001810 active site 768492001811 I-site; other site 768492001812 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 768492001813 Helix-turn-helix domains; Region: HTH; cl00088 768492001814 LysR family transcriptional regulator; Provisional; Region: PRK14997 768492001815 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 768492001816 putative effector binding pocket; other site 768492001817 putative dimerization interface [polypeptide binding]; other site 768492001818 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768492001819 active site 768492001820 catalytic tetrad [active] 768492001821 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 768492001822 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 768492001823 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492001824 S-adenosylmethionine binding site [chemical binding]; other site 768492001825 DNA polymerase III psi subunit; Region: DNA_III_psi; cl11436 768492001826 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 768492001827 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492001828 Coenzyme A binding pocket [chemical binding]; other site 768492001829 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 768492001830 HipA N-terminal domain; Region: Couple_hipA; cl11853 768492001831 HipA-like N-terminal domain; Region: HipA_N; pfam07805 768492001832 HipA-like C-terminal domain; Region: HipA_C; pfam07804 768492001833 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 768492001834 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 768492001835 G1 box; other site 768492001836 putative GEF interaction site [polypeptide binding]; other site 768492001837 GTP/Mg2+ binding site [chemical binding]; other site 768492001838 Switch I region; other site 768492001839 G2 box; other site 768492001840 G3 box; other site 768492001841 Switch II region; other site 768492001842 G4 box; other site 768492001843 G5 box; other site 768492001844 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 768492001845 periplasmic protein; Provisional; Region: PRK10568 768492001846 BON domain; Region: BON; cl02771 768492001847 BON domain; Region: BON; cl02771 768492001848 CsbD-like; Region: CsbD; cl15799 768492001849 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 768492001850 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 768492001851 active site 768492001852 nucleophile elbow; other site 768492001853 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 768492001854 active site 768492001855 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 768492001856 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 768492001857 Nucleoside recognition; Region: Gate; cl00486 768492001858 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 768492001859 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 768492001860 intersubunit interface [polypeptide binding]; other site 768492001861 active site 768492001862 catalytic residue [active] 768492001863 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 768492001864 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 768492001865 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 768492001866 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 768492001867 Sulfatase; Region: Sulfatase; cl10460 768492001868 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 768492001869 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 768492001870 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 768492001871 Bacterial virulence factor haemolysin; Region: SMP_2; cl11479 768492001872 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 768492001873 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492001874 motif II; other site 768492001875 DNA repair protein RadA; Provisional; Region: PRK11823 768492001876 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 768492001877 Walker A motif/ATP binding site; other site 768492001878 ATP binding site [chemical binding]; other site 768492001879 Walker B motif; other site 768492001880 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 768492001881 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492001882 non-specific DNA binding site [nucleotide binding]; other site 768492001883 salt bridge; other site 768492001884 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 768492001885 sequence-specific DNA binding site [nucleotide binding]; other site 768492001886 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768492001887 active site 768492001888 nucleotide binding site [chemical binding]; other site 768492001889 HIGH motif; other site 768492001890 KMSKS motif; other site 768492001891 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492001892 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 768492001893 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 768492001894 putative NAD(P) binding site [chemical binding]; other site 768492001895 dimer interface [polypeptide binding]; other site 768492001896 LysR family transcriptional regulator; Provisional; Region: PRK14997 768492001897 Helix-turn-helix domains; Region: HTH; cl00088 768492001898 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492001899 putative effector binding pocket; other site 768492001900 dimerization interface [polypeptide binding]; other site 768492001901 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 768492001902 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 768492001903 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 768492001904 ABC transporter; Region: ABC_tran_2; pfam12848 768492001905 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 768492001906 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 768492001907 ligand binding site [chemical binding]; other site 768492001908 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 768492001909 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 768492001910 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768492001911 metal binding site [ion binding]; metal-binding site 768492001912 active site 768492001913 I-site; other site 768492001914 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 768492001915 lytic murein transglycosylase; Provisional; Region: PRK11619 768492001916 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 768492001917 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768492001918 catalytic residue [active] 768492001919 Helix-turn-helix domains; Region: HTH; cl00088 768492001920 Protein of unknown function DUF84; Region: NTPase_I-T; cl00866 768492001921 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768492001922 catalytic core [active] 768492001923 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 768492001924 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492001925 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 768492001926 hypothetical protein; Provisional; Region: PRK10756 768492001927 CreA protein; Region: CreA; pfam05981 768492001928 two-component response regulator; Provisional; Region: PRK11173 768492001929 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492001930 active site 768492001931 phosphorylation site [posttranslational modification] 768492001932 intermolecular recognition site; other site 768492001933 dimerization interface [polypeptide binding]; other site 768492001934 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768492001935 DNA binding site [nucleotide binding] 768492001936 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 768492001937 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 768492001938 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 768492001939 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 768492001940 putative catalytic residues [active] 768492001941 putative nucleotide binding site [chemical binding]; other site 768492001942 putative aspartate binding site [chemical binding]; other site 768492001943 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 768492001944 dimer interface [polypeptide binding]; other site 768492001945 putative threonine allosteric regulatory site; other site 768492001946 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 768492001947 putative threonine allosteric regulatory site; other site 768492001948 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492001949 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 768492001950 homoserine kinase; Provisional; Region: PRK01212 768492001951 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 768492001952 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 768492001953 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 768492001954 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 768492001955 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492001956 catalytic residue [active] 768492001957 Protein of unknown function (DUF328); Region: DUF328; cl01143 768492001958 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 768492001959 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 768492001960 transaldolase-like protein; Provisional; Region: PTZ00411 768492001961 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 768492001962 active site 768492001963 dimer interface [polypeptide binding]; other site 768492001964 catalytic residue [active] 768492001965 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 768492001966 MPT binding site; other site 768492001967 trimer interface [polypeptide binding]; other site 768492001968 metabolite-proton symporter; Region: 2A0106; TIGR00883 768492001969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492001970 putative substrate translocation pore; other site 768492001971 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 768492001972 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 768492001973 chaperone protein DnaJ; Provisional; Region: PRK10767 768492001974 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 768492001975 HSP70 interaction site [polypeptide binding]; other site 768492001976 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 768492001977 substrate binding site [polypeptide binding]; other site 768492001978 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 768492001979 Zn binding sites [ion binding]; other site 768492001980 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 768492001981 dimer interface [polypeptide binding]; other site 768492001982 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 768492001983 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 768492001984 Helix-turn-helix domains; Region: HTH; cl00088 768492001985 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 768492001986 putative dimerization interface [polypeptide binding]; other site 768492001987 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 768492001988 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 768492001989 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 768492001990 active site 768492001991 Riboflavin kinase; Region: Flavokinase; cl03312 768492001992 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 768492001993 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768492001994 active site 768492001995 HIGH motif; other site 768492001996 nucleotide binding site [chemical binding]; other site 768492001997 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 768492001998 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 768492001999 active site 768492002000 KMSKS motif; other site 768492002001 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 768492002002 tRNA binding surface [nucleotide binding]; other site 768492002003 anticodon binding site; other site 768492002004 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 768492002005 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 768492002006 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 768492002007 LytB protein; Region: LYTB; cl00507 768492002008 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 768492002009 transcriptional regulator; Provisional; Region: PRK10632 768492002010 Helix-turn-helix domains; Region: HTH; cl00088 768492002011 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492002012 putative effector binding pocket; other site 768492002013 dimerization interface [polypeptide binding]; other site 768492002014 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 768492002015 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 768492002016 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 768492002017 substrate binding pocket [chemical binding]; other site 768492002018 active site 768492002019 iron coordination sites [ion binding]; other site 768492002020 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 768492002021 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 768492002022 active site 768492002023 TDP-binding site; other site 768492002024 acceptor substrate-binding pocket; other site 768492002025 dihydrodipicolinate reductase; Provisional; Region: PRK00048 768492002026 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492002027 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 768492002028 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 768492002029 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 768492002030 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 768492002031 catalytic site [active] 768492002032 subunit interface [polypeptide binding]; other site 768492002033 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 768492002034 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 768492002035 ATP-grasp domain; Region: ATP-grasp_4; cl03087 768492002036 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 768492002037 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 768492002038 ATP-grasp domain; Region: ATP-grasp_4; cl03087 768492002039 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 768492002040 IMP binding site; other site 768492002041 dimer interface [polypeptide binding]; other site 768492002042 interdomain contacts; other site 768492002043 partial ornithine binding site; other site 768492002044 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 768492002045 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 768492002046 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 768492002047 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492002048 LysE type translocator; Region: LysE; cl00565 768492002049 Uncharacterized conserved protein [Function unknown]; Region: COG2966 768492002050 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 768492002051 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 768492002052 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 768492002053 folate binding site [chemical binding]; other site 768492002054 NADP+ binding site [chemical binding]; other site 768492002055 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 768492002056 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 768492002057 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 768492002058 active site 768492002059 metal binding site [ion binding]; metal-binding site 768492002060 Protein of unknown function (DUF525); Region: DUF525; cl01119 768492002061 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 768492002062 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 768492002063 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 768492002064 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 768492002065 SurA N-terminal domain; Region: SurA_N_3; cl07813 768492002066 PPIC-type PPIASE domain; Region: Rotamase; cl08278 768492002067 PPIC-type PPIASE domain; Region: Rotamase; cl08278 768492002068 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 768492002069 OstA-like protein; Region: OstA; cl00844 768492002070 Organic solvent tolerance protein; Region: OstA_C; pfam04453 768492002071 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 768492002072 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 768492002073 putative metal binding site [ion binding]; other site 768492002074 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 768492002075 HSP70 interaction site [polypeptide binding]; other site 768492002076 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 768492002077 active site 768492002078 ATP-dependent helicase HepA; Validated; Region: PRK04914 768492002079 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768492002080 ATP binding site [chemical binding]; other site 768492002081 putative Mg++ binding site [ion binding]; other site 768492002082 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768492002083 nucleotide binding region [chemical binding]; other site 768492002084 ATP-binding site [chemical binding]; other site 768492002085 DNA polymerase II; Reviewed; Region: PRK05762 768492002086 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 768492002087 active site 768492002088 catalytic site [active] 768492002089 substrate binding site [chemical binding]; other site 768492002090 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 768492002091 active site 768492002092 metal-binding site 768492002093 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 768492002094 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 768492002095 putative valine binding site [chemical binding]; other site 768492002096 dimer interface [polypeptide binding]; other site 768492002097 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 768492002098 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768492002099 PYR/PP interface [polypeptide binding]; other site 768492002100 dimer interface [polypeptide binding]; other site 768492002101 TPP binding site [chemical binding]; other site 768492002102 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 768492002103 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 768492002104 TPP-binding site [chemical binding]; other site 768492002105 dimer interface [polypeptide binding]; other site 768492002106 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 768492002107 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492002108 Walker A/P-loop; other site 768492002109 ATP binding site [chemical binding]; other site 768492002110 Q-loop/lid; other site 768492002111 ABC transporter signature motif; other site 768492002112 Walker B; other site 768492002113 D-loop; other site 768492002114 H-loop/switch region; other site 768492002115 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 768492002116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492002117 putative PBP binding loops; other site 768492002118 ABC-ATPase subunit interface; other site 768492002119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492002120 dimer interface [polypeptide binding]; other site 768492002121 conserved gate region; other site 768492002122 putative PBP binding loops; other site 768492002123 ABC-ATPase subunit interface; other site 768492002124 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492002125 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 768492002126 transcriptional regulator SgrR; Provisional; Region: PRK13626 768492002127 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 768492002128 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 768492002129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492002130 sugar efflux transporter; Region: 2A0120; TIGR00899 768492002131 putative substrate translocation pore; other site 768492002132 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 768492002133 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 768492002134 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 768492002135 substrate binding site [chemical binding]; other site 768492002136 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 768492002137 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 768492002138 substrate binding site [chemical binding]; other site 768492002139 ligand binding site [chemical binding]; other site 768492002140 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 768492002141 tartrate dehydrogenase; Provisional; Region: PRK08194 768492002142 2-isopropylmalate synthase; Validated; Region: PRK00915 768492002143 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 768492002144 active site 768492002145 catalytic residues [active] 768492002146 metal binding site [ion binding]; metal-binding site 768492002147 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 768492002148 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 768492002149 Helix-turn-helix domains; Region: HTH; cl00088 768492002150 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 768492002151 putative substrate binding pocket [chemical binding]; other site 768492002152 putative dimerization interface [polypeptide binding]; other site 768492002153 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 768492002154 AMP-binding enzyme; Region: AMP-binding; cl15778 768492002155 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 768492002156 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768492002157 PYR/PP interface [polypeptide binding]; other site 768492002158 dimer interface [polypeptide binding]; other site 768492002159 TPP binding site [chemical binding]; other site 768492002160 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 768492002161 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 768492002162 TPP-binding site [chemical binding]; other site 768492002163 dimer interface [polypeptide binding]; other site 768492002164 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 768492002165 putative valine binding site [chemical binding]; other site 768492002166 dimer interface [polypeptide binding]; other site 768492002167 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 768492002168 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 768492002169 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492002170 DNA binding site [nucleotide binding] 768492002171 domain linker motif; other site 768492002172 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 768492002173 dimerization interface [polypeptide binding]; other site 768492002174 ligand binding site [chemical binding]; other site 768492002175 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 768492002176 cell division protein MraZ; Reviewed; Region: PRK00326 768492002177 MraZ protein; Region: MraZ; pfam02381 768492002178 MraZ protein; Region: MraZ; pfam02381 768492002179 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 768492002180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 768492002181 Septum formation initiator; Region: DivIC; cl11433 768492002182 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 768492002183 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 768492002184 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 768492002185 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 768492002186 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 768492002187 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768492002188 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768492002189 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 768492002190 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 768492002191 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768492002192 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768492002193 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 768492002194 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 768492002195 Mg++ binding site [ion binding]; other site 768492002196 putative catalytic motif [active] 768492002197 putative substrate binding site [chemical binding]; other site 768492002198 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 768492002199 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768492002200 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768492002201 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 768492002202 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 768492002203 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 768492002204 active site 768492002205 homodimer interface [polypeptide binding]; other site 768492002206 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 768492002207 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 768492002208 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768492002209 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768492002210 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 768492002211 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 768492002212 ATP-grasp domain; Region: ATP-grasp_4; cl03087 768492002213 cell division protein FtsQ; Provisional; Region: PRK10775 768492002214 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 768492002215 Cell division protein FtsQ; Region: FtsQ; pfam03799 768492002216 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 768492002217 Cell division protein FtsA; Region: FtsA; cl11496 768492002218 Cell division protein FtsA; Region: FtsA; cl11496 768492002219 cell division protein FtsZ; Validated; Region: PRK09330 768492002220 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 768492002221 nucleotide binding site [chemical binding]; other site 768492002222 SulA interaction site; other site 768492002223 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 768492002224 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 768492002225 Protein of unknown function (DUF721); Region: DUF721; cl02324 768492002226 Secretion monitor precursor protein (SecM); Region: SecM; cl11636 768492002227 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 768492002228 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 768492002229 SEC-C motif; Region: SEC-C; pfam02810 768492002230 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 768492002231 active site 768492002232 8-oxo-dGMP binding site [chemical binding]; other site 768492002233 nudix motif; other site 768492002234 metal binding site [ion binding]; metal-binding site 768492002235 Domain of unknown function (DUF329); Region: DUF329; cl01144 768492002236 Protein of unknown function (DUF1342); Region: DUF1342; cl01892 768492002237 dephospho-CoA kinase; Region: TIGR00152 768492002238 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 768492002239 CoA-binding site [chemical binding]; other site 768492002240 ATP-binding [chemical binding]; other site 768492002241 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 768492002242 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 768492002243 active site 768492002244 type IV pilin biogenesis protein; Provisional; Region: PRK10573 768492002245 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 768492002246 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 768492002247 hypothetical protein; Provisional; Region: PRK10436 768492002248 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 768492002249 Walker A motif; other site 768492002250 ATP binding site [chemical binding]; other site 768492002251 Walker B motif; other site 768492002252 putative major pilin subunit; Provisional; Region: PRK10574 768492002253 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 768492002254 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 768492002255 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 768492002256 dimerization interface [polypeptide binding]; other site 768492002257 active site 768492002258 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 768492002259 amidase catalytic site [active] 768492002260 Zn binding residues [ion binding]; other site 768492002261 substrate binding site [chemical binding]; other site 768492002262 CobD/Cbib protein; Region: CobD_Cbib; cl00561 768492002263 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 768492002264 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768492002265 inhibitor-cofactor binding pocket; inhibition site 768492002266 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492002267 catalytic residue [active] 768492002268 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 768492002269 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 768492002270 Cl- selectivity filter; other site 768492002271 Cl- binding residues [ion binding]; other site 768492002272 pore gating glutamate residue; other site 768492002273 dimer interface [polypeptide binding]; other site 768492002274 H+/Cl- coupling transport residue; other site 768492002275 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 768492002276 hypothetical protein; Provisional; Region: PRK10578 768492002277 UPF0126 domain; Region: UPF0126; pfam03458 768492002278 UPF0126 domain; Region: UPF0126; pfam03458 768492002279 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 768492002280 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 768492002281 cobalamin binding residues [chemical binding]; other site 768492002282 putative BtuC binding residues; other site 768492002283 dimer interface [polypeptide binding]; other site 768492002284 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 768492002285 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 768492002286 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 768492002287 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 768492002288 serine endoprotease; Provisional; Region: PRK10942 768492002289 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 768492002290 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 768492002291 protein binding site [polypeptide binding]; other site 768492002292 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 768492002293 protein binding site [polypeptide binding]; other site 768492002294 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 768492002295 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 768492002296 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 768492002297 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492002298 dimer interface [polypeptide binding]; other site 768492002299 phosphorylation site [posttranslational modification] 768492002300 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492002301 ATP binding site [chemical binding]; other site 768492002302 Mg2+ binding site [ion binding]; other site 768492002303 G-X-G motif; other site 768492002304 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 768492002305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492002306 active site 768492002307 phosphorylation site [posttranslational modification] 768492002308 intermolecular recognition site; other site 768492002309 dimerization interface [polypeptide binding]; other site 768492002310 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 768492002311 putative binding surface; other site 768492002312 active site 768492002313 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 768492002314 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 768492002315 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 768492002316 synthetase active site [active] 768492002317 NTP binding site [chemical binding]; other site 768492002318 metal binding site [ion binding]; metal-binding site 768492002319 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 768492002320 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 768492002321 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 768492002322 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 768492002323 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 768492002324 CTP synthetase; Validated; Region: pyrG; PRK05380 768492002325 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 768492002326 Catalytic site [active] 768492002327 active site 768492002328 UTP binding site [chemical binding]; other site 768492002329 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 768492002330 active site 768492002331 putative oxyanion hole; other site 768492002332 catalytic triad [active] 768492002333 enolase; Provisional; Region: eno; PRK00077 768492002334 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 768492002335 dimer interface [polypeptide binding]; other site 768492002336 metal binding site [ion binding]; metal-binding site 768492002337 substrate binding pocket [chemical binding]; other site 768492002338 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 768492002339 methionine gamma-lyase; Provisional; Region: PRK07503 768492002340 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 768492002341 homodimer interface [polypeptide binding]; other site 768492002342 substrate-cofactor binding pocket; other site 768492002343 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492002344 catalytic residue [active] 768492002345 putative proline-specific permease; Provisional; Region: proY; PRK10580 768492002346 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 768492002347 active sites [active] 768492002348 tetramer interface [polypeptide binding]; other site 768492002349 urocanate hydratase; Provisional; Region: PRK05414 768492002350 benzoate transport; Region: 2A0115; TIGR00895 768492002351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492002352 putative substrate translocation pore; other site 768492002353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492002354 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 768492002355 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 768492002356 active site 768492002357 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 768492002358 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 768492002359 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 768492002360 FAD binding pocket [chemical binding]; other site 768492002361 FAD binding motif [chemical binding]; other site 768492002362 catalytic residues [active] 768492002363 NAD binding pocket [chemical binding]; other site 768492002364 phosphate binding motif [ion binding]; other site 768492002365 beta-alpha-beta structure motif; other site 768492002366 sulfite reductase subunit beta; Provisional; Region: PRK13504 768492002367 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 768492002368 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 768492002369 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 768492002370 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 768492002371 Active Sites [active] 768492002372 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 768492002373 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 768492002374 metal binding site [ion binding]; metal-binding site 768492002375 siroheme synthase; Provisional; Region: cysG; PRK10637 768492002376 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492002377 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 768492002378 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 768492002379 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 768492002380 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 768492002381 Active Sites [active] 768492002382 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 768492002383 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 768492002384 CysD dimerization site [polypeptide binding]; other site 768492002385 G1 box; other site 768492002386 putative GEF interaction site [polypeptide binding]; other site 768492002387 GTP/Mg2+ binding site [chemical binding]; other site 768492002388 Switch I region; other site 768492002389 G2 box; other site 768492002390 G3 box; other site 768492002391 Switch II region; other site 768492002392 G4 box; other site 768492002393 G5 box; other site 768492002394 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 768492002395 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 768492002396 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 768492002397 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 768492002398 ligand-binding site [chemical binding]; other site 768492002399 Protein of unknown function (DUF3561); Region: DUF3561; cl08142 768492002400 Septum formation initiator; Region: DivIC; cl11433 768492002401 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 768492002402 substrate binding site; other site 768492002403 dimer interface; other site 768492002404 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 768492002405 homotrimer interaction site [polypeptide binding]; other site 768492002406 zinc binding site [ion binding]; other site 768492002407 CDP-binding sites; other site 768492002408 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 768492002409 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 768492002410 Permutation of conserved domain; other site 768492002411 active site 768492002412 Survival protein SurE; Region: SurE; cl00448 768492002413 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 768492002414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492002415 S-adenosylmethionine binding site [chemical binding]; other site 768492002416 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 768492002417 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 768492002418 putative peptidoglycan binding site; other site 768492002419 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 768492002420 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 768492002421 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768492002422 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 768492002423 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768492002424 DNA binding residues [nucleotide binding] 768492002425 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 768492002426 MutS domain I; Region: MutS_I; pfam01624 768492002427 MutS domain II; Region: MutS_II; pfam05188 768492002428 MutS family domain IV; Region: MutS_IV; pfam05190 768492002429 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 768492002430 Walker A/P-loop; other site 768492002431 ATP binding site [chemical binding]; other site 768492002432 Q-loop/lid; other site 768492002433 ABC transporter signature motif; other site 768492002434 Walker B; other site 768492002435 D-loop; other site 768492002436 H-loop/switch region; other site 768492002437 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 768492002438 active site 768492002439 P-loop; other site 768492002440 phosphorylation site [posttranslational modification] 768492002441 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 768492002442 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 768492002443 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 768492002444 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 768492002445 Cupin domain; Region: Cupin_2; cl09118 768492002446 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492002447 YdjC-like protein; Region: YdjC; cl01344 768492002448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492002449 putative substrate translocation pore; other site 768492002450 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768492002451 Competence-damaged protein; Region: CinA; cl00666 768492002452 recombinase A; Provisional; Region: recA; PRK09354 768492002453 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 768492002454 hexamer interface [polypeptide binding]; other site 768492002455 Walker A motif; other site 768492002456 ATP binding site [chemical binding]; other site 768492002457 Walker B motif; other site 768492002458 RecX family; Region: RecX; cl00936 768492002459 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 768492002460 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 768492002461 motif 1; other site 768492002462 active site 768492002463 motif 2; other site 768492002464 motif 3; other site 768492002465 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 768492002466 DHHA1 domain; Region: DHHA1; pfam02272 768492002467 Global regulator protein family; Region: CsrA; cl00670 768492002468 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 768492002469 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492002470 motif II; other site 768492002471 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 768492002472 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 768492002473 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 768492002474 hypothetical protein; Provisional; Region: PRK11573 768492002475 Domain of unknown function DUF21; Region: DUF21; pfam01595 768492002476 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 768492002477 Transporter associated domain; Region: CorC_HlyC; cl08393 768492002478 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 768492002479 signal recognition particle protein; Provisional; Region: PRK10867 768492002480 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 768492002481 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 768492002482 P loop; other site 768492002483 GTP binding site [chemical binding]; other site 768492002484 Signal peptide binding domain; Region: SRP_SPB; pfam02978 768492002485 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 768492002486 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 768492002487 RimM N-terminal domain; Region: RimM; pfam01782 768492002488 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 768492002489 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 768492002490 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 768492002491 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 768492002492 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 768492002493 Phage P2 GpU; Region: Phage_P2_GpU; cl01391 768492002494 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 768492002495 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 768492002496 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 768492002497 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 768492002498 Phage tail tube protein FII; Region: Phage_tube; cl01390 768492002499 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 768492002500 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; cl05448 768492002501 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 768492002502 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 768492002503 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 768492002504 Baseplate J-like protein; Region: Baseplate_J; cl01294 768492002505 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 768492002506 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 768492002507 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 768492002508 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 768492002509 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 768492002510 catalytic residues [active] 768492002511 Phage Tail Protein X; Region: Phage_tail_X; cl02088 768492002512 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 768492002513 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 768492002514 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 768492002515 Protein of unknown function, DUF481; Region: DUF481; cl01213 768492002516 NeuB family; Region: NeuB; cl00496 768492002517 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 768492002518 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 768492002519 Chorismate mutase type II; Region: CM_2; cl00693 768492002520 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492002521 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 768492002522 Chorismate mutase type II; Region: CM_2; cl00693 768492002523 Prephenate dehydratase; Region: PDT; pfam00800 768492002524 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 768492002525 putative L-Phe binding site [chemical binding]; other site 768492002526 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 768492002527 30S subunit binding site; other site 768492002528 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 768492002529 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 768492002530 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768492002531 RNA binding surface [nucleotide binding]; other site 768492002532 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 768492002533 active site 768492002534 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 768492002535 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 768492002536 protein disaggregation chaperone; Provisional; Region: PRK10865 768492002537 Clp amino terminal domain; Region: Clp_N; pfam02861 768492002538 Clp amino terminal domain; Region: Clp_N; pfam02861 768492002539 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492002540 Walker A motif; other site 768492002541 ATP binding site [chemical binding]; other site 768492002542 Walker B motif; other site 768492002543 arginine finger; other site 768492002544 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492002545 Walker A motif; other site 768492002546 ATP binding site [chemical binding]; other site 768492002547 Walker B motif; other site 768492002548 arginine finger; other site 768492002549 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 768492002550 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 768492002551 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 768492002552 putative acyl-acceptor binding pocket; other site 768492002553 Phosphopantetheine attachment site; Region: PP-binding; cl09936 768492002554 Phosphopantetheine attachment site; Region: PP-binding; cl09936 768492002555 Predicted membrane protein [Function unknown]; Region: COG4648 768492002556 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 768492002557 AMP-binding enzyme; Region: AMP-binding; cl15778 768492002558 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 768492002559 active site 2 [active] 768492002560 active site 1 [active] 768492002561 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 768492002562 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 768492002563 Ligand binding site; other site 768492002564 Putative Catalytic site; other site 768492002565 DXD motif; other site 768492002566 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 768492002567 putative acyl-acceptor binding pocket; other site 768492002568 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 768492002569 active site 768492002570 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 768492002571 Predicted exporter [General function prediction only]; Region: COG4258 768492002572 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 768492002573 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 768492002574 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 768492002575 dimer interface [polypeptide binding]; other site 768492002576 active site 768492002577 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 768492002578 putative active site 1 [active] 768492002579 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 768492002580 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 768492002581 NAD(P) binding site [chemical binding]; other site 768492002582 homotetramer interface [polypeptide binding]; other site 768492002583 homodimer interface [polypeptide binding]; other site 768492002584 active site 768492002585 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 768492002586 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 768492002587 dimer interface [polypeptide binding]; other site 768492002588 active site 768492002589 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768492002590 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768492002591 active site 768492002592 catalytic tetrad [active] 768492002593 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492002594 Helix-turn-helix domains; Region: HTH; cl00088 768492002595 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492002596 dimerization interface [polypeptide binding]; other site 768492002597 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768492002598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492002599 putative substrate translocation pore; other site 768492002600 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 768492002601 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 768492002602 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 768492002603 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768492002604 catalytic residue [active] 768492002605 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 768492002606 putative peptidoglycan binding site; other site 768492002607 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 768492002608 putative peptidoglycan binding site; other site 768492002609 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 768492002610 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 768492002611 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 768492002612 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 768492002613 RNA/DNA hybrid binding site [nucleotide binding]; other site 768492002614 active site 768492002615 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 768492002616 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 768492002617 active site 768492002618 catalytic site [active] 768492002619 substrate binding site [chemical binding]; other site 768492002620 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 768492002621 Na binding site [ion binding]; other site 768492002622 putative substrate binding site [chemical binding]; other site 768492002623 Transcriptional regulators [Transcription]; Region: FadR; COG2186 768492002624 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492002625 DNA-binding site [nucleotide binding]; DNA binding site 768492002626 FCD domain; Region: FCD; cl11656 768492002627 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 768492002628 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 768492002629 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 768492002630 active site 768492002631 catalytic site [active] 768492002632 tetramer interface [polypeptide binding]; other site 768492002633 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 768492002634 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 768492002635 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 768492002636 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768492002637 N-terminal plug; other site 768492002638 ligand-binding site [chemical binding]; other site 768492002639 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 768492002640 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 768492002641 IucA / IucC family; Region: IucA_IucC; pfam04183 768492002642 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 768492002643 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 768492002644 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 768492002645 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 768492002646 IucA / IucC family; Region: IucA_IucC; pfam04183 768492002647 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 768492002648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492002649 putative substrate translocation pore; other site 768492002650 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 768492002651 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 768492002652 FAD binding pocket [chemical binding]; other site 768492002653 FAD binding motif [chemical binding]; other site 768492002654 phosphate binding motif [ion binding]; other site 768492002655 NAD binding pocket [chemical binding]; other site 768492002656 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 768492002657 amidase; Provisional; Region: PRK09201 768492002658 Amidase; Region: Amidase; cl11426 768492002659 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 768492002660 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 768492002661 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 768492002662 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768492002663 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768492002664 putative active site [active] 768492002665 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768492002666 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492002667 substrate binding pocket [chemical binding]; other site 768492002668 membrane-bound complex binding site; other site 768492002669 hinge residues; other site 768492002670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492002671 dimer interface [polypeptide binding]; other site 768492002672 conserved gate region; other site 768492002673 putative PBP binding loops; other site 768492002674 ABC-ATPase subunit interface; other site 768492002675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 768492002676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492002677 ABC-ATPase subunit interface; other site 768492002678 putative PBP binding loops; other site 768492002679 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 768492002680 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 768492002681 Walker A/P-loop; other site 768492002682 ATP binding site [chemical binding]; other site 768492002683 Q-loop/lid; other site 768492002684 ABC transporter signature motif; other site 768492002685 Walker B; other site 768492002686 D-loop; other site 768492002687 H-loop/switch region; other site 768492002688 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 768492002689 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768492002690 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492002691 catalytic residue [active] 768492002692 allantoate amidohydrolase; Reviewed; Region: PRK09290 768492002693 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 768492002694 active site 768492002695 metal binding site [ion binding]; metal-binding site 768492002696 dimer interface [polypeptide binding]; other site 768492002697 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 768492002698 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 768492002699 active site 768492002700 homotetramer interface [polypeptide binding]; other site 768492002701 xanthine permease; Region: pbuX; TIGR03173 768492002702 Predicted amidohydrolase [General function prediction only]; Region: COG0388 768492002703 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 768492002704 putative active site [active] 768492002705 catalytic triad [active] 768492002706 dimer interface [polypeptide binding]; other site 768492002707 multimer interface [polypeptide binding]; other site 768492002708 methionine aminotransferase; Validated; Region: PRK09082 768492002709 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492002710 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492002711 homodimer interface [polypeptide binding]; other site 768492002712 catalytic residue [active] 768492002713 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 768492002714 intersubunit interface [polypeptide binding]; other site 768492002715 active site 768492002716 Zn2+ binding site [ion binding]; other site 768492002717 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 768492002718 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 768492002719 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 768492002720 Cupin domain; Region: Cupin_2; cl09118 768492002721 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 768492002722 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 768492002723 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 768492002724 Hok/gef family; Region: HOK_GEF; cl11494 768492002725 Hok/gef family; Region: HOK_GEF; cl11494 768492002726 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 768492002727 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 768492002728 active site 768492002729 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 768492002730 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 768492002731 dimer interface [polypeptide binding]; other site 768492002732 active site 768492002733 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 768492002734 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 768492002735 putative active site [active] 768492002736 putative dimer interface [polypeptide binding]; other site 768492002737 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 768492002738 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 768492002739 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 768492002740 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 768492002741 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 768492002742 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 768492002743 FMN-binding domain; Region: FMN_bind; cl01081 768492002744 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 768492002745 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 768492002746 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 768492002747 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 768492002748 FAD binding pocket [chemical binding]; other site 768492002749 FAD binding motif [chemical binding]; other site 768492002750 phosphate binding motif [ion binding]; other site 768492002751 beta-alpha-beta structure motif; other site 768492002752 NAD binding pocket [chemical binding]; other site 768492002753 ApbE family; Region: ApbE; cl00643 768492002754 Protein of unknown function (DUF539); Region: DUF539; cl01129 768492002755 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 768492002756 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 768492002757 active site 768492002758 catalytic site [active] 768492002759 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 768492002760 active site 768492002761 DNA polymerase IV; Validated; Region: PRK02406 768492002762 DNA binding site [nucleotide binding] 768492002763 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 768492002764 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 768492002765 metal binding site [ion binding]; metal-binding site 768492002766 dimer interface [polypeptide binding]; other site 768492002767 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768492002768 active site 768492002769 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 768492002770 Transcriptional regulator Crl; Region: Crl; cl11653 768492002771 gamma-glutamyl kinase; Provisional; Region: PRK05429 768492002772 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 768492002773 nucleotide binding site [chemical binding]; other site 768492002774 homotetrameric interface [polypeptide binding]; other site 768492002775 putative phosphate binding site [ion binding]; other site 768492002776 putative allosteric binding site; other site 768492002777 PUA domain; Region: PUA; cl00607 768492002778 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 768492002779 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 768492002780 putative catalytic cysteine [active] 768492002781 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318 768492002782 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 768492002783 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 768492002784 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492002785 non-specific DNA binding site [nucleotide binding]; other site 768492002786 salt bridge; other site 768492002787 sequence-specific DNA binding site [nucleotide binding]; other site 768492002788 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 768492002789 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 768492002790 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 768492002791 peptide binding site [polypeptide binding]; other site 768492002792 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 768492002793 Condensation domain; Region: Condensation; pfam00668 768492002794 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 768492002795 Nonribosomal peptide synthase; Region: NRPS; pfam08415 768492002796 AMP-binding enzyme; Region: AMP-binding; cl15778 768492002797 acyl-CoA synthetase; Validated; Region: PRK08308 768492002798 Condensation domain; Region: Condensation; pfam00668 768492002799 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 768492002800 Nonribosomal peptide synthase; Region: NRPS; pfam08415 768492002801 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 768492002802 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768492002803 N-terminal plug; other site 768492002804 ligand-binding site [chemical binding]; other site 768492002805 peptide synthase; Provisional; Region: PRK12467 768492002806 peptide synthase; Validated; Region: PRK05691 768492002807 Phosphopantetheine attachment site; Region: PP-binding; cl09936 768492002808 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 768492002809 Uncharacterized conserved protein [Function unknown]; Region: COG3391 768492002810 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 768492002811 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 768492002812 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 768492002813 catalytic residues [active] 768492002814 hinge region; other site 768492002815 alpha helical domain; other site 768492002816 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 768492002817 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492002818 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 768492002819 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 768492002820 NAD(P) binding site [chemical binding]; other site 768492002821 catalytic residues [active] 768492002822 LysE type translocator; Region: LysE; cl00565 768492002823 tellurite resistance protein TehB; Provisional; Region: PRK12335 768492002824 Domain of unknown function (DUF1971); Region: DUF1971; cl01451 768492002825 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 768492002826 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 768492002827 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 768492002828 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 768492002829 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 768492002830 C-terminal domain interface [polypeptide binding]; other site 768492002831 GSH binding site (G-site) [chemical binding]; other site 768492002832 dimer interface [polypeptide binding]; other site 768492002833 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 768492002834 N-terminal domain interface [polypeptide binding]; other site 768492002835 dimer interface [polypeptide binding]; other site 768492002836 substrate binding pocket (H-site) [chemical binding]; other site 768492002837 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768492002838 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 768492002839 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492002840 Helix-turn-helix domains; Region: HTH; cl00088 768492002841 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492002842 dimerization interface [polypeptide binding]; other site 768492002843 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 768492002844 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 768492002845 dimer interface [polypeptide binding]; other site 768492002846 PYR/PP interface [polypeptide binding]; other site 768492002847 TPP binding site [chemical binding]; other site 768492002848 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 768492002849 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 768492002850 TPP-binding site [chemical binding]; other site 768492002851 dimer interface [polypeptide binding]; other site 768492002852 Antimicrobial peptide resistance and lipid A acylation protein PagP; Region: PagP; cl06181 768492002853 Protein of unknown function (DUF2501); Region: DUF2501; cl08197 768492002854 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 768492002855 Domain of unknown function (DUF333); Region: DUF333; pfam03891 768492002856 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 768492002857 Helix-turn-helix domains; Region: HTH; cl00088 768492002858 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 768492002859 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 768492002860 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768492002861 active site 768492002862 metal binding site [ion binding]; metal-binding site 768492002863 LysR family transcriptional regulator; Provisional; Region: PRK14997 768492002864 Helix-turn-helix domains; Region: HTH; cl00088 768492002865 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 768492002866 putative effector binding pocket; other site 768492002867 putative dimerization interface [polypeptide binding]; other site 768492002868 Pirin-related protein [General function prediction only]; Region: COG1741 768492002869 Cupin domain; Region: Cupin_2; cl09118 768492002870 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 768492002871 Isochorismatase family; Region: Isochorismatase; pfam00857 768492002872 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 768492002873 catalytic triad [active] 768492002874 dimer interface [polypeptide binding]; other site 768492002875 conserved cis-peptide bond; other site 768492002876 aconitate hydratase, mitochondrial; Region: aconitase_mito; TIGR01340 768492002877 Protein of unknown function, DUF393; Region: DUF393; cl01136 768492002878 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768492002879 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 768492002880 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; cl01353 768492002881 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; cl01353 768492002882 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492002883 salt bridge; other site 768492002884 non-specific DNA binding site [nucleotide binding]; other site 768492002885 sequence-specific DNA binding site [nucleotide binding]; other site 768492002886 Methyltransferase domain; Region: Methyltransf_31; pfam13847 768492002887 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492002888 S-adenosylmethionine binding site [chemical binding]; other site 768492002889 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 768492002890 amphipathic channel; other site 768492002891 Asn-Pro-Ala signature motifs; other site 768492002892 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 768492002893 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 768492002894 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 768492002895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 768492002896 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492002897 Coenzyme A binding pocket [chemical binding]; other site 768492002898 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 768492002899 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 768492002900 putative ligand binding residues [chemical binding]; other site 768492002901 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768492002902 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492002903 Coenzyme A binding pocket [chemical binding]; other site 768492002904 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 768492002905 Shikimate kinase; Region: SKI; pfam01202 768492002906 ADP binding site [chemical binding]; other site 768492002907 magnesium binding site [ion binding]; other site 768492002908 putative shikimate binding site; other site 768492002909 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 768492002910 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768492002911 active site 768492002912 catalytic tetrad [active] 768492002913 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492002914 Helix-turn-helix domains; Region: HTH; cl00088 768492002915 Cupin domain; Region: Cupin_2; cl09118 768492002916 Helix-turn-helix domain; Region: HTH_18; pfam12833 768492002917 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492002918 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 768492002919 hypothetical protein; Provisional; Region: PRK10380 768492002920 Protein of unknown function (DUF1255); Region: DUF1255; cl01202 768492002921 Putative exonuclease, RdgC; Region: RdgC; cl01122 768492002922 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 768492002923 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 768492002924 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 768492002925 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768492002926 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 768492002927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492002928 ATP binding site [chemical binding]; other site 768492002929 Mg2+ binding site [ion binding]; other site 768492002930 G-X-G motif; other site 768492002931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492002932 active site 768492002933 phosphorylation site [posttranslational modification] 768492002934 intermolecular recognition site; other site 768492002935 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 768492002936 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 768492002937 Walker A/P-loop; other site 768492002938 ATP binding site [chemical binding]; other site 768492002939 Q-loop/lid; other site 768492002940 ABC transporter signature motif; other site 768492002941 Walker B; other site 768492002942 D-loop; other site 768492002943 H-loop/switch region; other site 768492002944 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 768492002945 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768492002946 TM-ABC transporter signature motif; other site 768492002947 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 768492002948 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 768492002949 putative ligand binding site [chemical binding]; other site 768492002950 Cupin domain; Region: Cupin_2; cl09118 768492002951 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 768492002952 intersubunit interface [polypeptide binding]; other site 768492002953 active site 768492002954 zinc binding site [ion binding]; other site 768492002955 Na+ binding site [ion binding]; other site 768492002956 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 768492002957 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768492002958 substrate binding site [chemical binding]; other site 768492002959 ATP binding site [chemical binding]; other site 768492002960 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768492002961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492002962 active site 768492002963 phosphorylation site [posttranslational modification] 768492002964 intermolecular recognition site; other site 768492002965 dimerization interface [polypeptide binding]; other site 768492002966 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768492002967 DNA binding site [nucleotide binding] 768492002968 fructokinase; Reviewed; Region: PRK09557 768492002969 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 768492002970 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 768492002971 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 768492002972 putative active site [active] 768492002973 transcriptional antiterminator BglG; Provisional; Region: PRK09772 768492002974 CAT RNA binding domain; Region: CAT_RBD; cl03904 768492002975 PRD domain; Region: PRD; cl15445 768492002976 PRD domain; Region: PRD; cl15445 768492002977 ethanolamine permease; Region: 2A0305; TIGR00908 768492002978 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492002979 AAA domain; Region: AAA_23; pfam13476 768492002980 Walker A/P-loop; other site 768492002981 ATP binding site [chemical binding]; other site 768492002982 Q-loop/lid; other site 768492002983 exonuclease subunit SbcC; Provisional; Region: PRK10246 768492002984 exonuclease subunit SbcC; Provisional; Region: PRK10246 768492002985 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492002986 ABC transporter signature motif; other site 768492002987 Walker B; other site 768492002988 D-loop; other site 768492002989 H-loop/switch region; other site 768492002990 exonuclease subunit SbcD; Provisional; Region: PRK10966 768492002991 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 768492002992 active site 768492002993 metal binding site [ion binding]; metal-binding site 768492002994 DNA binding site [nucleotide binding] 768492002995 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 768492002996 transcriptional regulator PhoB; Provisional; Region: PRK10161 768492002997 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492002998 active site 768492002999 phosphorylation site [posttranslational modification] 768492003000 intermolecular recognition site; other site 768492003001 dimerization interface [polypeptide binding]; other site 768492003002 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768492003003 DNA binding site [nucleotide binding] 768492003004 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 768492003005 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 768492003006 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 768492003007 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492003008 dimer interface [polypeptide binding]; other site 768492003009 phosphorylation site [posttranslational modification] 768492003010 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492003011 ATP binding site [chemical binding]; other site 768492003012 Mg2+ binding site [ion binding]; other site 768492003013 G-X-G motif; other site 768492003014 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492003015 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 768492003016 substrate binding site [chemical binding]; other site 768492003017 THF binding site; other site 768492003018 zinc-binding site [ion binding]; other site 768492003019 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 768492003020 putative proline-specific permease; Provisional; Region: proY; PRK10580 768492003021 Spore germination protein; Region: Spore_permease; cl15802 768492003022 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 768492003023 Mechanosensitive ion channel; Region: MS_channel; pfam00924 768492003024 maltodextrin glucosidase; Provisional; Region: PRK10785 768492003025 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 768492003026 homodimer interface [polypeptide binding]; other site 768492003027 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 768492003028 active site 768492003029 homodimer interface [polypeptide binding]; other site 768492003030 catalytic site [active] 768492003031 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 768492003032 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 768492003033 peroxidase; Provisional; Region: PRK15000 768492003034 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 768492003035 dimer interface [polypeptide binding]; other site 768492003036 decamer (pentamer of dimers) interface [polypeptide binding]; other site 768492003037 catalytic triad [active] 768492003038 peroxidatic and resolving cysteines [active] 768492003039 Protein of unknown function, DUF479; Region: DUF479; cl01203 768492003040 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 768492003041 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 768492003042 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 768492003043 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 768492003044 Preprotein translocase subunit; Region: YajC; cl00806 768492003045 SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136 768492003046 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 768492003047 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 768492003048 Protein export membrane protein; Region: SecD_SecF; cl14618 768492003049 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 768492003050 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 768492003051 Protein export membrane protein; Region: SecD_SecF; cl14618 768492003052 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 768492003053 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 768492003054 ATP cone domain; Region: ATP-cone; pfam03477 768492003055 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 768492003056 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 768492003057 catalytic motif [active] 768492003058 Zn binding site [ion binding]; other site 768492003059 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 768492003060 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 768492003061 homopentamer interface [polypeptide binding]; other site 768492003062 active site 768492003063 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 768492003064 putative RNA binding site [nucleotide binding]; other site 768492003065 thiamine monophosphate kinase; Provisional; Region: PRK05731 768492003066 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 768492003067 ATP binding site [chemical binding]; other site 768492003068 dimerization interface [polypeptide binding]; other site 768492003069 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 768492003070 tetramer interfaces [polypeptide binding]; other site 768492003071 binuclear metal-binding site [ion binding]; other site 768492003072 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 768492003073 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768492003074 active site 768492003075 catalytic tetrad [active] 768492003076 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 768492003077 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 768492003078 TPP-binding site; other site 768492003079 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 768492003080 PYR/PP interface [polypeptide binding]; other site 768492003081 dimer interface [polypeptide binding]; other site 768492003082 TPP binding site [chemical binding]; other site 768492003083 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768492003084 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 768492003085 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 768492003086 substrate binding pocket [chemical binding]; other site 768492003087 chain length determination region; other site 768492003088 substrate-Mg2+ binding site; other site 768492003089 catalytic residues [active] 768492003090 aspartate-rich region 1; other site 768492003091 active site lid residues [active] 768492003092 aspartate-rich region 2; other site 768492003093 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 768492003094 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 768492003095 THUMP domain; Region: THUMP; cl12076 768492003096 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 768492003097 Ligand Binding Site [chemical binding]; other site 768492003098 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 768492003099 active site residue [active] 768492003100 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 768492003101 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 768492003102 conserved cys residue [active] 768492003103 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 768492003104 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492003105 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 768492003106 Protein of unknown function (DUF520); Region: DUF520; cl00723 768492003107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492003108 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768492003109 putative substrate translocation pore; other site 768492003110 UbiA prenyltransferase family; Region: UbiA; cl00337 768492003111 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 768492003112 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 768492003113 Subunit I/III interface [polypeptide binding]; other site 768492003114 Subunit III/IV interface [polypeptide binding]; other site 768492003115 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 768492003116 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 768492003117 D-pathway; other site 768492003118 Putative ubiquinol binding site [chemical binding]; other site 768492003119 Low-spin heme (heme b) binding site [chemical binding]; other site 768492003120 Putative water exit pathway; other site 768492003121 Binuclear center (heme o3/CuB) [ion binding]; other site 768492003122 K-pathway; other site 768492003123 Putative proton exit pathway; other site 768492003124 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 768492003125 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 768492003126 AmpG-related permease; Region: 2A0125; TIGR00901 768492003127 Acetyl-coenzyme A transporter 1; Region: Acatn; pfam13000 768492003128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492003129 putative substrate translocation pore; other site 768492003130 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 768492003131 BolA-like protein; Region: BolA; cl00386 768492003132 trigger factor; Provisional; Region: tig; PRK01490 768492003133 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 768492003134 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 768492003135 Clp protease; Region: CLP_protease; pfam00574 768492003136 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 768492003137 oligomer interface [polypeptide binding]; other site 768492003138 active site residues [active] 768492003139 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 768492003140 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 768492003141 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492003142 Walker A motif; other site 768492003143 ATP binding site [chemical binding]; other site 768492003144 Walker B motif; other site 768492003145 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 768492003146 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 768492003147 Found in ATP-dependent protease La (LON); Region: LON; smart00464 768492003148 Found in ATP-dependent protease La (LON); Region: LON; smart00464 768492003149 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492003150 Walker A motif; other site 768492003151 ATP binding site [chemical binding]; other site 768492003152 Walker B motif; other site 768492003153 arginine finger; other site 768492003154 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 768492003155 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 768492003156 IHF dimer interface [polypeptide binding]; other site 768492003157 IHF - DNA interface [nucleotide binding]; other site 768492003158 periplasmic folding chaperone; Provisional; Region: PRK10788 768492003159 SurA N-terminal domain; Region: SurA_N_3; cl07813 768492003160 PPIC-type PPIASE domain; Region: Rotamase; cl08278 768492003161 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 768492003162 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 768492003163 active site 768492003164 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 768492003165 Ligand Binding Site [chemical binding]; other site 768492003166 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 768492003167 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 768492003168 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 768492003169 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 768492003170 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492003171 active site 768492003172 motif I; other site 768492003173 motif II; other site 768492003174 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 768492003175 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 768492003176 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 768492003177 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492003178 catalytic residue [active] 768492003179 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768492003180 Helix-turn-helix domains; Region: HTH; cl00088 768492003181 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 768492003182 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 768492003183 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492003184 Walker A/P-loop; other site 768492003185 ATP binding site [chemical binding]; other site 768492003186 Q-loop/lid; other site 768492003187 ABC transporter signature motif; other site 768492003188 Walker B; other site 768492003189 D-loop; other site 768492003190 H-loop/switch region; other site 768492003191 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 768492003192 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 768492003193 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 768492003194 Walker A/P-loop; other site 768492003195 ATP binding site [chemical binding]; other site 768492003196 Q-loop/lid; other site 768492003197 ABC transporter signature motif; other site 768492003198 Walker B; other site 768492003199 D-loop; other site 768492003200 H-loop/switch region; other site 768492003201 Nitrogen regulatory protein P-II; Region: P-II; cl00412 768492003202 Nitrogen regulatory protein P-II; Region: P-II; smart00938 768492003203 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 768492003204 acyl-CoA thioesterase II; Provisional; Region: PRK10526 768492003205 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 768492003206 active site 768492003207 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 768492003208 catalytic triad [active] 768492003209 dimer interface [polypeptide binding]; other site 768492003210 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 768492003211 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 768492003212 DNA binding site [nucleotide binding] 768492003213 active site 768492003214 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768492003215 active site 768492003216 DNA binding site [nucleotide binding] 768492003217 Int/Topo IB signature motif; other site 768492003218 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 768492003219 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768492003220 active site 768492003221 DNA binding site [nucleotide binding] 768492003222 Int/Topo IB signature motif; other site 768492003223 Helix-turn-helix domains; Region: HTH; cl00088 768492003224 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 768492003225 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442 768492003226 Helix-turn-helix domains; Region: HTH; cl00088 768492003227 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 768492003228 Right handed beta helix region; Region: Beta_helix; pfam13229 768492003229 Haemolysin expression modulating protein; Region: HHA; cl11501 768492003230 Biofilm formation regulator YbaJ; Region: YbaJ; cl11675 768492003231 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 768492003232 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 768492003233 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768492003234 ABC-ATPase subunit interface; other site 768492003235 dimer interface [polypeptide binding]; other site 768492003236 putative PBP binding regions; other site 768492003237 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 768492003238 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 768492003239 metal binding site [ion binding]; metal-binding site 768492003240 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 768492003241 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 768492003242 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 768492003243 Protein export membrane protein; Region: SecD_SecF; cl14618 768492003244 Protein export membrane protein; Region: SecD_SecF; cl14618 768492003245 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 768492003246 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 768492003247 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 768492003248 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 768492003249 Helix-turn-helix domains; Region: HTH; cl00088 768492003250 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 768492003251 DsrE/DsrF-like family; Region: DrsE; cl00672 768492003252 hypothetical protein; Provisional; Region: PRK11281 768492003253 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 768492003254 Mechanosensitive ion channel; Region: MS_channel; pfam00924 768492003255 Protein of unknown function (DUF2496); Region: DUF2496; cl11670 768492003256 Primosomal replication protein priB and priC; Region: priB_priC; cl11483 768492003257 Protein of unknown function (DUF454); Region: DUF454; cl01063 768492003258 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 768492003259 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768492003260 active site 768492003261 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 768492003262 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492003263 Walker A motif; other site 768492003264 ATP binding site [chemical binding]; other site 768492003265 Walker B motif; other site 768492003266 arginine finger; other site 768492003267 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 768492003268 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 768492003269 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 768492003270 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 768492003271 recombination protein RecR; Reviewed; Region: recR; PRK00076 768492003272 RecR protein; Region: RecR; pfam02132 768492003273 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 768492003274 putative active site [active] 768492003275 putative metal-binding site [ion binding]; other site 768492003276 tetramer interface [polypeptide binding]; other site 768492003277 heat shock protein 90; Provisional; Region: PRK05218 768492003278 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492003279 ATP binding site [chemical binding]; other site 768492003280 Mg2+ binding site [ion binding]; other site 768492003281 G-X-G motif; other site 768492003282 adenylate kinase; Reviewed; Region: adk; PRK00279 768492003283 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 768492003284 AMP-binding site [chemical binding]; other site 768492003285 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 768492003286 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 768492003287 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 768492003288 Helix-turn-helix domains; Region: HTH; cl00088 768492003289 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 768492003290 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 768492003291 Glycerate kinase family; Region: Gly_kinase; cl00841 768492003292 ferrochelatase; Reviewed; Region: hemH; PRK00035 768492003293 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 768492003294 C-terminal domain interface [polypeptide binding]; other site 768492003295 active site 768492003296 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 768492003297 active site 768492003298 N-terminal domain interface [polypeptide binding]; other site 768492003299 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768492003300 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 768492003301 substrate binding site [chemical binding]; other site 768492003302 ATP binding site [chemical binding]; other site 768492003303 putative cation:proton antiport protein; Provisional; Region: PRK10669 768492003304 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 768492003305 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492003306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492003307 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768492003308 putative substrate translocation pore; other site 768492003309 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 768492003310 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 768492003311 active site 768492003312 metal binding site [ion binding]; metal-binding site 768492003313 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 768492003314 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 768492003315 putative deacylase active site [active] 768492003316 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 768492003317 TraB family; Region: TraB; cl12050 768492003318 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 768492003319 metal-binding site [ion binding] 768492003320 copper exporting ATPase; Provisional; Region: copA; PRK10671 768492003321 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 768492003322 metal-binding site [ion binding] 768492003323 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 768492003324 metal-binding site [ion binding] 768492003325 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768492003326 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492003327 motif II; other site 768492003328 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 768492003329 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 768492003330 DNA binding residues [nucleotide binding] 768492003331 dimer interface [polypeptide binding]; other site 768492003332 copper binding site [ion binding]; other site 768492003333 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 768492003334 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 768492003335 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 768492003336 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 768492003337 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492003338 S-adenosylmethionine binding site [chemical binding]; other site 768492003339 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 768492003340 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 768492003341 short chain dehydrogenase; Validated; Region: PRK06182 768492003342 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 768492003343 NADP binding site [chemical binding]; other site 768492003344 active site 768492003345 steroid binding site; other site 768492003346 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 768492003347 active site 768492003348 catalytic triad [active] 768492003349 oxyanion hole [active] 768492003350 switch loop; other site 768492003351 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 768492003352 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 768492003353 Walker A/P-loop; other site 768492003354 ATP binding site [chemical binding]; other site 768492003355 Q-loop/lid; other site 768492003356 ABC transporter signature motif; other site 768492003357 Walker B; other site 768492003358 D-loop; other site 768492003359 H-loop/switch region; other site 768492003360 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 768492003361 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768492003362 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 768492003363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492003364 putative substrate translocation pore; other site 768492003365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492003366 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 768492003367 ATP-grasp domain; Region: ATP-grasp_4; cl03087 768492003368 AIR carboxylase; Region: AIRC; cl00310 768492003369 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 768492003370 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 768492003371 putative active site [active] 768492003372 putative metal binding site [ion binding]; other site 768492003373 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 768492003374 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 768492003375 substrate binding site [chemical binding]; other site 768492003376 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 768492003377 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 768492003378 active site 768492003379 HIGH motif; other site 768492003380 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 768492003381 KMSKS motif; other site 768492003382 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 768492003383 tRNA binding surface [nucleotide binding]; other site 768492003384 anticodon binding site; other site 768492003385 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 768492003386 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 768492003387 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 768492003388 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 768492003389 homodimer interface [polypeptide binding]; other site 768492003390 NADP binding site [chemical binding]; other site 768492003391 substrate binding site [chemical binding]; other site 768492003392 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 768492003393 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 768492003394 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 768492003395 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492003396 Helix-turn-helix domains; Region: HTH; cl00088 768492003397 Fimbrial protein; Region: Fimbrial; cl01416 768492003398 Fimbrial protein; Region: Fimbrial; cl01416 768492003399 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 768492003400 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 768492003401 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 768492003402 outer membrane usher protein; Provisional; Region: PRK15193 768492003403 PapC N-terminal domain; Region: PapC_N; pfam13954 768492003404 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 768492003405 PapC C-terminal domain; Region: PapC_C; pfam13953 768492003406 Fimbrial protein; Region: Fimbrial; cl01416 768492003407 Fimbrial protein; Region: Fimbrial; cl01416 768492003408 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 768492003409 mannosyl binding site [chemical binding]; other site 768492003410 Fimbrial protein; Region: Fimbrial; cl01416 768492003411 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 768492003412 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 768492003413 Active Sites [active] 768492003414 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 768492003415 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 768492003416 ParB-like nuclease domain; Region: ParBc; cl02129 768492003417 L-lactate permease; Region: Lactate_perm; cl00701 768492003418 Cysteine-rich domain; Region: CCG; pfam02754 768492003419 Cysteine-rich domain; Region: CCG; pfam02754 768492003420 iron-sulfur cluster-binding protein; Region: TIGR00273 768492003421 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 768492003422 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768492003423 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 768492003424 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 768492003425 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 768492003426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492003427 active site 768492003428 phosphorylation site [posttranslational modification] 768492003429 intermolecular recognition site; other site 768492003430 dimerization interface [polypeptide binding]; other site 768492003431 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492003432 Walker A motif; other site 768492003433 ATP binding site [chemical binding]; other site 768492003434 Walker B motif; other site 768492003435 arginine finger; other site 768492003436 Helix-turn-helix domains; Region: HTH; cl00088 768492003437 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492003438 phosphorylation site [posttranslational modification] 768492003439 dimer interface [polypeptide binding]; other site 768492003440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492003441 ATP binding site [chemical binding]; other site 768492003442 Mg2+ binding site [ion binding]; other site 768492003443 G-X-G motif; other site 768492003444 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 768492003445 conserved cys residue [active] 768492003446 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768492003447 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492003448 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492003449 'elongating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP) thioesters as...; Region: elong_cond_enzymes; cd00828 768492003450 3-oxoacyl-acyl carrier protein synthase; Provisional; Region: PTZ00050 768492003451 active site 768492003452 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 768492003453 acyl-CoA synthetase; Validated; Region: PRK05850 768492003454 AMP-binding enzyme; Region: AMP-binding; cl15778 768492003455 Phosphopantetheine attachment site; Region: PP-binding; cl09936 768492003456 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 768492003457 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 768492003458 active site 768492003459 Acyl transferase domain; Region: Acyl_transf_1; cl08282 768492003460 Phosphopantetheine attachment site; Region: PP-binding; cl09936 768492003461 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 768492003462 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768492003463 inhibitor-cofactor binding pocket; inhibition site 768492003464 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492003465 catalytic residue [active] 768492003466 Condensation domain; Region: Condensation; pfam00668 768492003467 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 768492003468 Arylesterase; Region: Arylesterase; pfam01731 768492003469 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 768492003470 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768492003471 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 768492003472 catalytic loop [active] 768492003473 iron binding site [ion binding]; other site 768492003474 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 768492003475 FAD binding pocket [chemical binding]; other site 768492003476 conserved FAD binding motif [chemical binding]; other site 768492003477 phosphate binding motif [ion binding]; other site 768492003478 beta-alpha-beta structure motif; other site 768492003479 NAD binding pocket [chemical binding]; other site 768492003480 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 768492003481 putative di-iron ligands [ion binding]; other site 768492003482 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 768492003483 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768492003484 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 768492003485 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 768492003486 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 768492003487 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 768492003488 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 768492003489 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768492003490 active site 768492003491 catalytic tetrad [active] 768492003492 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492003493 Helix-turn-helix domains; Region: HTH; cl00088 768492003494 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 768492003495 putative effector binding pocket; other site 768492003496 putative dimerization interface [polypeptide binding]; other site 768492003497 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 768492003498 MASE1; Region: MASE1; pfam05231 768492003499 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768492003500 metal binding site [ion binding]; metal-binding site 768492003501 active site 768492003502 I-site; other site 768492003503 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 768492003504 DNA-binding site [nucleotide binding]; DNA binding site 768492003505 RNA-binding motif; other site 768492003506 The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6, and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348 768492003507 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768492003508 putative active site [active] 768492003509 putative metal binding site [ion binding]; other site 768492003510 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 768492003511 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492003512 Walker A/P-loop; other site 768492003513 ATP binding site [chemical binding]; other site 768492003514 Q-loop/lid; other site 768492003515 ABC transporter signature motif; other site 768492003516 Walker B; other site 768492003517 D-loop; other site 768492003518 H-loop/switch region; other site 768492003519 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492003520 dimer interface [polypeptide binding]; other site 768492003521 conserved gate region; other site 768492003522 putative PBP binding loops; other site 768492003523 ABC-ATPase subunit interface; other site 768492003524 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768492003525 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492003526 Coenzyme A binding pocket [chemical binding]; other site 768492003527 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 768492003528 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 768492003529 active site 768492003530 non-prolyl cis peptide bond; other site 768492003531 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 768492003532 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 768492003533 metal binding site [ion binding]; metal-binding site 768492003534 dimer interface [polypeptide binding]; other site 768492003535 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 768492003536 DNA-binding site [nucleotide binding]; DNA binding site 768492003537 RNA-binding motif; other site 768492003538 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 768492003539 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492003540 putative substrate translocation pore; other site 768492003541 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492003542 Helix-turn-helix domains; Region: HTH; cl00088 768492003543 CrcB-like protein; Region: CRCB; cl09114 768492003544 putative acetyltransferase; Provisional; Region: PRK03624 768492003545 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492003546 Coenzyme A binding pocket [chemical binding]; other site 768492003547 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 768492003548 MASE2 domain; Region: MASE2; pfam05230 768492003549 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768492003550 metal binding site [ion binding]; metal-binding site 768492003551 active site 768492003552 I-site; other site 768492003553 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 768492003554 lipoyl synthase; Provisional; Region: PRK05481 768492003555 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768492003556 FeS/SAM binding site; other site 768492003557 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 768492003558 Protein of unknown function (DUF493); Region: DUF493; cl01102 768492003559 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 768492003560 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 768492003561 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 768492003562 rare lipoprotein A; Provisional; Region: PRK10672 768492003563 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 768492003564 Sporulation related domain; Region: SPOR; cl10051 768492003565 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 768492003566 penicillin-binding protein 2; Provisional; Region: PRK10795 768492003567 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 768492003568 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 768492003569 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 768492003570 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 768492003571 Oligomerisation domain; Region: Oligomerisation; cl00519 768492003572 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 768492003573 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 768492003574 active site 768492003575 (T/H)XGH motif; other site 768492003576 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 768492003577 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 768492003578 Lipopolysaccharide-assembly; Region: LptE; cl01125 768492003579 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 768492003580 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 768492003581 HIGH motif; other site 768492003582 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 768492003583 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768492003584 active site 768492003585 KMSKS motif; other site 768492003586 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 768492003587 tRNA binding surface [nucleotide binding]; other site 768492003588 hypothetical protein; Provisional; Region: PRK11032 768492003589 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 768492003590 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 768492003591 active site 768492003592 tetramer interface [polypeptide binding]; other site 768492003593 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 768492003594 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 768492003595 Walker A/P-loop; other site 768492003596 ATP binding site [chemical binding]; other site 768492003597 Q-loop/lid; other site 768492003598 ABC transporter signature motif; other site 768492003599 Walker B; other site 768492003600 D-loop; other site 768492003601 H-loop/switch region; other site 768492003602 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768492003603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492003604 dimer interface [polypeptide binding]; other site 768492003605 conserved gate region; other site 768492003606 putative PBP binding loops; other site 768492003607 ABC-ATPase subunit interface; other site 768492003608 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768492003609 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492003610 dimer interface [polypeptide binding]; other site 768492003611 conserved gate region; other site 768492003612 putative PBP binding loops; other site 768492003613 ABC-ATPase subunit interface; other site 768492003614 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 768492003615 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492003616 substrate binding pocket [chemical binding]; other site 768492003617 membrane-bound complex binding site; other site 768492003618 hinge residues; other site 768492003619 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 768492003620 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 768492003621 putative active site [active] 768492003622 catalytic triad [active] 768492003623 putative dimer interface [polypeptide binding]; other site 768492003624 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 768492003625 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 768492003626 Transporter associated domain; Region: CorC_HlyC; cl08393 768492003627 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 768492003628 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 768492003629 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492003630 hypothetical protein; Provisional; Region: PRK10220 768492003631 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 768492003632 PhnA protein; Region: PhnA; pfam03831 768492003633 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 768492003634 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 768492003635 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768492003636 FeS/SAM binding site; other site 768492003637 TRAM domain; Region: TRAM; cl01282 768492003638 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 768492003639 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492003640 asparagine synthetase B; Provisional; Region: asnB; PRK09431 768492003641 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 768492003642 active site 768492003643 dimer interface [polypeptide binding]; other site 768492003644 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 768492003645 Ligand Binding Site [chemical binding]; other site 768492003646 Molecular Tunnel; other site 768492003647 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 768492003648 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 768492003649 putative active site [active] 768492003650 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 768492003651 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 768492003652 UMP phosphatase; Provisional; Region: PRK10444 768492003653 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492003654 active site 768492003655 motif I; other site 768492003656 motif II; other site 768492003657 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492003658 Helix-turn-helix domains; Region: HTH; cl00088 768492003659 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 768492003660 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 768492003661 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 768492003662 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 768492003663 active site 768492003664 dimer interface [polypeptide binding]; other site 768492003665 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 768492003666 active site 768492003667 trimer interface [polypeptide binding]; other site 768492003668 allosteric site; other site 768492003669 active site lid [active] 768492003670 hexamer (dimer of trimers) interface [polypeptide binding]; other site 768492003671 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 768492003672 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 768492003673 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768492003674 active site turn [active] 768492003675 phosphorylation site [posttranslational modification] 768492003676 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 768492003677 HPr interaction site; other site 768492003678 glycerol kinase (GK) interaction site [polypeptide binding]; other site 768492003679 active site 768492003680 phosphorylation site [posttranslational modification] 768492003681 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 768492003682 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768492003683 active site 768492003684 HIGH motif; other site 768492003685 nucleotide binding site [chemical binding]; other site 768492003686 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 768492003687 KMSKS motif; other site 768492003688 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 768492003689 outer membrane porin, OprD family; Region: OprD; pfam03573 768492003690 YbfN-like lipoprotein; Region: YbfN; pfam13982 768492003691 Putative carbohydrate binding domain; Region: CHB_HEX; cl03918 768492003692 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 768492003693 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 768492003694 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a...; Region: GH20_Sm-chitobiase-like; cd06569 768492003695 active site 768492003696 C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847 768492003697 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492003698 sugar efflux transporter; Region: 2A0120; TIGR00899 768492003699 putative substrate translocation pore; other site 768492003700 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 768492003701 UDP-glucose 4-epimerase; Region: PLN02240 768492003702 NAD binding site [chemical binding]; other site 768492003703 homodimer interface [polypeptide binding]; other site 768492003704 active site 768492003705 substrate binding site [chemical binding]; other site 768492003706 TcdB toxin N-terminal helical domain; Region: TcdB_N; pfam12918 768492003707 TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919 768492003708 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 768492003709 ferric uptake regulator; Provisional; Region: fur; PRK09462 768492003710 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 768492003711 metal binding site 2 [ion binding]; metal-binding site 768492003712 putative DNA binding helix; other site 768492003713 metal binding site 1 [ion binding]; metal-binding site 768492003714 dimer interface [polypeptide binding]; other site 768492003715 structural Zn2+ binding site [ion binding]; other site 768492003716 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 768492003717 LexA regulated protein; Provisional; Region: PRK11675 768492003718 acyl-CoA esterase; Provisional; Region: PRK10673 768492003719 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 768492003720 SeqA protein; Region: SeqA; cl11470 768492003721 phosphoglucomutase; Validated; Region: PRK07564 768492003722 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 768492003723 active site 768492003724 substrate binding site [chemical binding]; other site 768492003725 metal binding site [ion binding]; metal-binding site 768492003726 Helix-turn-helix domains; Region: HTH; cl00088 768492003727 Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977 768492003728 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 768492003729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492003730 active site 768492003731 phosphorylation site [posttranslational modification] 768492003732 intermolecular recognition site; other site 768492003733 dimerization interface [polypeptide binding]; other site 768492003734 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768492003735 DNA binding site [nucleotide binding] 768492003736 sensor protein KdpD; Provisional; Region: PRK10490 768492003737 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 768492003738 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 768492003739 Ligand Binding Site [chemical binding]; other site 768492003740 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 768492003741 GAF domain; Region: GAF; cl15785 768492003742 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492003743 dimer interface [polypeptide binding]; other site 768492003744 phosphorylation site [posttranslational modification] 768492003745 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492003746 ATP binding site [chemical binding]; other site 768492003747 Mg2+ binding site [ion binding]; other site 768492003748 G-X-G motif; other site 768492003749 K+-transporting ATPase, c chain; Region: KdpC; cl00944 768492003750 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 768492003751 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768492003752 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 768492003753 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 768492003754 Protein of unknown function (DUF523); Region: DUF523; cl00733 768492003755 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 768492003756 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 768492003757 DNA photolyase; Region: DNA_photolyase; pfam00875 768492003758 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 768492003759 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 768492003760 Uncharacterized conserved protein [Function unknown]; Region: COG0327 768492003761 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 768492003762 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 768492003763 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 768492003764 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 768492003765 LamB/YcsF family; Region: LamB_YcsF; cl00664 768492003766 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 768492003767 putative substrate binding pocket [chemical binding]; other site 768492003768 AC domain interface; other site 768492003769 catalytic triad [active] 768492003770 AB domain interface; other site 768492003771 interchain disulfide; other site 768492003772 endonuclease VIII; Provisional; Region: PRK10445 768492003773 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 768492003774 DNA binding site [nucleotide binding] 768492003775 catalytic residue [active] 768492003776 H2TH interface [polypeptide binding]; other site 768492003777 putative catalytic residues [active] 768492003778 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 768492003779 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 768492003780 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 768492003781 dimer interface [polypeptide binding]; other site 768492003782 Citrate synthase; Region: Citrate_synt; pfam00285 768492003783 active site 768492003784 citrylCoA binding site [chemical binding]; other site 768492003785 NADH binding [chemical binding]; other site 768492003786 cationic pore residues; other site 768492003787 oxalacetate/citrate binding site [chemical binding]; other site 768492003788 coenzyme A binding site [chemical binding]; other site 768492003789 catalytic triad [active] 768492003790 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 768492003791 Iron-sulfur protein interface; other site 768492003792 proximal quinone binding site [chemical binding]; other site 768492003793 SdhD (CybS) interface [polypeptide binding]; other site 768492003794 proximal heme binding site [chemical binding]; other site 768492003795 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 768492003796 SdhC subunit interface [polypeptide binding]; other site 768492003797 proximal heme binding site [chemical binding]; other site 768492003798 cardiolipin binding site; other site 768492003799 Iron-sulfur protein interface; other site 768492003800 proximal quinone binding site [chemical binding]; other site 768492003801 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 768492003802 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492003803 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 768492003804 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 768492003805 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 768492003806 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 768492003807 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 768492003808 TPP-binding site [chemical binding]; other site 768492003809 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 768492003810 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 768492003811 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768492003812 E3 interaction surface; other site 768492003813 lipoyl attachment site [posttranslational modification]; other site 768492003814 e3 binding domain; Region: E3_binding; pfam02817 768492003815 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 768492003816 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 768492003817 ATP-grasp domain; Region: ATP-grasp_4; cl03087 768492003818 CoA-ligase; Region: Ligase_CoA; cl02894 768492003819 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 768492003820 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492003821 CoA-ligase; Region: Ligase_CoA; cl02894 768492003822 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 768492003823 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 768492003824 active site 768492003825 metal binding site [ion binding]; metal-binding site 768492003826 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 768492003827 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 768492003828 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 768492003829 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 768492003830 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 768492003831 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 768492003832 Cyd operon protein YbgE (Cyd_oper_YbgE); Region: Cyd_oper_YbgE; cl11451 768492003833 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 768492003834 active site 768492003835 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 768492003836 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 768492003837 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 768492003838 Gram-negative bacterial tonB protein; Region: TonB; cl10048 768492003839 translocation protein TolB; Provisional; Region: tolB; PRK03629 768492003840 TolB amino-terminal domain; Region: TolB_N; cl00639 768492003841 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 768492003842 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 768492003843 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 768492003844 Serglycin; Region: Serglycin; pfam04360 768492003845 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 768492003846 ligand binding site [chemical binding]; other site 768492003847 tol-pal system protein YbgF; Provisional; Region: PRK10803 768492003848 Tetratricopeptide repeat; Region: TPR_6; pfam13174 768492003849 Tetratricopeptide repeat; Region: TPR_6; pfam13174 768492003850 Quinolinate synthetase A protein; Region: NadA; cl00420 768492003851 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 768492003852 Cation efflux family; Region: Cation_efflux; cl00316 768492003853 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492003854 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768492003855 substrate binding pocket [chemical binding]; other site 768492003856 membrane-bound complex binding site; other site 768492003857 hinge residues; other site 768492003858 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768492003859 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492003860 substrate binding pocket [chemical binding]; other site 768492003861 membrane-bound complex binding site; other site 768492003862 hinge residues; other site 768492003863 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492003864 dimer interface [polypeptide binding]; other site 768492003865 phosphorylation site [posttranslational modification] 768492003866 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492003867 ATP binding site [chemical binding]; other site 768492003868 Mg2+ binding site [ion binding]; other site 768492003869 G-X-G motif; other site 768492003870 Response regulator receiver domain; Region: Response_reg; pfam00072 768492003871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492003872 active site 768492003873 phosphorylation site [posttranslational modification] 768492003874 intermolecular recognition site; other site 768492003875 dimerization interface [polypeptide binding]; other site 768492003876 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 768492003877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492003878 active site 768492003879 phosphorylation site [posttranslational modification] 768492003880 intermolecular recognition site; other site 768492003881 dimerization interface [polypeptide binding]; other site 768492003882 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492003883 DNA binding residues [nucleotide binding] 768492003884 dimerization interface [polypeptide binding]; other site 768492003885 NeuB family; Region: NeuB; cl00496 768492003886 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 768492003887 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768492003888 catalytic core [active] 768492003889 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768492003890 psiF repeat; Region: PsiF_repeat; pfam07769 768492003891 psiF repeat; Region: PsiF_repeat; pfam07769 768492003892 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 768492003893 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 768492003894 active site 768492003895 catalytic residues [active] 768492003896 galactokinase; Provisional; Region: PRK05101 768492003897 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 768492003898 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 768492003899 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 768492003900 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 768492003901 dimer interface [polypeptide binding]; other site 768492003902 active site 768492003903 CAAX protease self-immunity; Region: Abi; cl00558 768492003904 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 768492003905 catalytic triad [active] 768492003906 conserved cis-peptide bond; other site 768492003907 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 768492003908 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492003909 Walker A/P-loop; other site 768492003910 ATP binding site [chemical binding]; other site 768492003911 Q-loop/lid; other site 768492003912 ABC transporter signature motif; other site 768492003913 Walker B; other site 768492003914 D-loop; other site 768492003915 H-loop/switch region; other site 768492003916 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492003917 Walker A/P-loop; other site 768492003918 ATP binding site [chemical binding]; other site 768492003919 Q-loop/lid; other site 768492003920 ABC transporter signature motif; other site 768492003921 Walker B; other site 768492003922 D-loop; other site 768492003923 H-loop/switch region; other site 768492003924 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 768492003925 Helix-turn-helix domains; Region: HTH; cl00088 768492003926 TOBE domain; Region: TOBE_2; cl01440 768492003927 TOBE domain; Region: TOBE_2; cl01440 768492003928 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 768492003929 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492003930 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 768492003931 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492003932 dimer interface [polypeptide binding]; other site 768492003933 conserved gate region; other site 768492003934 putative PBP binding loops; other site 768492003935 ABC-ATPase subunit interface; other site 768492003936 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 768492003937 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492003938 Walker A/P-loop; other site 768492003939 ATP binding site [chemical binding]; other site 768492003940 Q-loop/lid; other site 768492003941 ABC transporter signature motif; other site 768492003942 Walker B; other site 768492003943 D-loop; other site 768492003944 H-loop/switch region; other site 768492003945 TOBE domain; Region: TOBE_2; cl01440 768492003946 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 768492003947 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492003948 active site 768492003949 motif I; other site 768492003950 motif II; other site 768492003951 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492003952 6-phosphogluconolactonase; Provisional; Region: PRK11028 768492003953 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 768492003954 substrate binding site [chemical binding]; other site 768492003955 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 768492003956 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 768492003957 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768492003958 inhibitor-cofactor binding pocket; inhibition site 768492003959 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492003960 catalytic residue [active] 768492003961 biotin synthase; Provisional; Region: PRK15108 768492003962 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768492003963 FeS/SAM binding site; other site 768492003964 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 768492003965 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 768492003966 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768492003967 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492003968 catalytic residue [active] 768492003969 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 768492003970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492003971 S-adenosylmethionine binding site [chemical binding]; other site 768492003972 AAA domain; Region: AAA_26; pfam13500 768492003973 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 768492003974 ADP binding site [chemical binding]; other site 768492003975 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 768492003976 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 768492003977 Walker A/P-loop; other site 768492003978 ATP binding site [chemical binding]; other site 768492003979 Q-loop/lid; other site 768492003980 ABC transporter signature motif; other site 768492003981 Walker B; other site 768492003982 D-loop; other site 768492003983 H-loop/switch region; other site 768492003984 excinuclease ABC subunit B; Provisional; Region: PRK05298 768492003985 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768492003986 ATP binding site [chemical binding]; other site 768492003987 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768492003988 nucleotide binding region [chemical binding]; other site 768492003989 ATP-binding site [chemical binding]; other site 768492003990 Ultra-violet resistance protein B; Region: UvrB; pfam12344 768492003991 UvrB/uvrC motif; Region: UVR; pfam02151 768492003992 Uncharacterized conserved protein (DUF2132); Region: DUF2132; cl01894 768492003993 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 768492003994 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 768492003995 phosphate binding site [ion binding]; other site 768492003996 putative substrate binding pocket [chemical binding]; other site 768492003997 dimer interface [polypeptide binding]; other site 768492003998 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 768492003999 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768492004000 FeS/SAM binding site; other site 768492004001 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 768492004002 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 768492004003 MPT binding site; other site 768492004004 trimer interface [polypeptide binding]; other site 768492004005 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 768492004006 trimer interface [polypeptide binding]; other site 768492004007 dimer interface [polypeptide binding]; other site 768492004008 putative active site [active] 768492004009 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 768492004010 MoaE interaction surface [polypeptide binding]; other site 768492004011 MoeB interaction surface [polypeptide binding]; other site 768492004012 thiocarboxylated glycine; other site 768492004013 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 768492004014 MoaE homodimer interface [polypeptide binding]; other site 768492004015 MoaD interaction [polypeptide binding]; other site 768492004016 active site residues [active] 768492004017 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 768492004018 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 768492004019 ABC-2 type transporter; Region: ABC2_membrane; cl11417 768492004020 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 768492004021 ABC-2 type transporter; Region: ABC2_membrane; cl11417 768492004022 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 768492004023 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 768492004024 Walker A/P-loop; other site 768492004025 ATP binding site [chemical binding]; other site 768492004026 Q-loop/lid; other site 768492004027 ABC transporter signature motif; other site 768492004028 Walker B; other site 768492004029 D-loop; other site 768492004030 H-loop/switch region; other site 768492004031 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 768492004032 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 768492004033 Walker A/P-loop; other site 768492004034 ATP binding site [chemical binding]; other site 768492004035 Q-loop/lid; other site 768492004036 ABC transporter signature motif; other site 768492004037 Walker B; other site 768492004038 D-loop; other site 768492004039 H-loop/switch region; other site 768492004040 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 768492004041 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 768492004042 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 768492004043 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 768492004044 Helix-turn-helix domains; Region: HTH; cl00088 768492004045 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 768492004046 helicase 45; Provisional; Region: PTZ00424 768492004047 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 768492004048 ATP binding site [chemical binding]; other site 768492004049 Mg++ binding site [ion binding]; other site 768492004050 motif III; other site 768492004051 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768492004052 nucleotide binding region [chemical binding]; other site 768492004053 ATP-binding site [chemical binding]; other site 768492004054 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 768492004055 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492004056 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 768492004057 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 768492004058 FMN binding site [chemical binding]; other site 768492004059 active site 768492004060 catalytic residues [active] 768492004061 substrate binding site [chemical binding]; other site 768492004062 N-acetyltransferase; Region: Acetyltransf_2; cl00949 768492004063 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492004064 Helix-turn-helix domains; Region: HTH; cl00088 768492004065 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492004066 dimerization interface [polypeptide binding]; other site 768492004067 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 768492004068 MatE; Region: MatE; cl10513 768492004069 ATP-grasp domain; Region: ATP-grasp_4; cl03087 768492004070 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768492004071 Helix-turn-helix domains; Region: HTH; cl00088 768492004072 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 768492004073 dimerization interface [polypeptide binding]; other site 768492004074 substrate binding pocket [chemical binding]; other site 768492004075 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 768492004076 L-asparagine permease; Provisional; Region: PRK15049 768492004077 Predicted membrane protein [Function unknown]; Region: COG4125 768492004078 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 768492004079 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 768492004080 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492004081 Helix-turn-helix domains; Region: HTH; cl00088 768492004082 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768492004083 dimerization interface [polypeptide binding]; other site 768492004084 LysE type translocator; Region: LysE; cl00565 768492004085 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 768492004086 DJ-1 family protein; Region: not_thiJ; TIGR01383 768492004087 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 768492004088 conserved cys residue [active] 768492004089 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 768492004090 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 768492004091 conserved cys residue [active] 768492004092 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492004093 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492004094 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492004095 oligomerization interface [polypeptide binding]; other site 768492004096 active site 768492004097 NAD+ binding site [chemical binding]; other site 768492004098 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 768492004099 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 768492004100 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768492004101 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492004102 Coenzyme A binding pocket [chemical binding]; other site 768492004103 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 768492004104 dimer interface [polypeptide binding]; other site 768492004105 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768492004106 Protein of unknown function (DUF808); Region: DUF808; cl01002 768492004107 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 768492004108 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492004109 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 768492004110 Coenzyme A binding pocket [chemical binding]; other site 768492004111 EamA-like transporter family; Region: EamA; cl01037 768492004112 EamA-like transporter family; Region: EamA; cl01037 768492004113 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492004114 Helix-turn-helix domains; Region: HTH; cl00088 768492004115 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492004116 dimerization interface [polypeptide binding]; other site 768492004117 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 768492004118 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 768492004119 DNA binding residues [nucleotide binding] 768492004120 putative dimer interface [polypeptide binding]; other site 768492004121 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 768492004122 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 768492004123 NMT1-like family; Region: NMT1_2; cl15260 768492004124 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 768492004125 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492004126 Coenzyme A binding pocket [chemical binding]; other site 768492004127 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 768492004128 putative trimer interface [polypeptide binding]; other site 768492004129 putative active site [active] 768492004130 putative substrate binding site [chemical binding]; other site 768492004131 putative CoA binding site [chemical binding]; other site 768492004132 Yip1 domain; Region: Yip1; cl12048 768492004133 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 768492004134 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 768492004135 NAD(P) binding site [chemical binding]; other site 768492004136 catalytic residues [active] 768492004137 D-lactate dehydrogenase; Provisional; Region: PRK11183 768492004138 FAD binding domain; Region: FAD_binding_4; pfam01565 768492004139 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 768492004140 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 768492004141 active site 768492004142 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 768492004143 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 768492004144 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 768492004145 ATP-grasp domain; Region: ATP-grasp_4; cl03087 768492004146 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 768492004147 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492004148 substrate binding pocket [chemical binding]; other site 768492004149 membrane-bound complex binding site; other site 768492004150 hinge residues; other site 768492004151 putative aminotransferase; Provisional; Region: PRK12414 768492004152 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492004153 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492004154 homodimer interface [polypeptide binding]; other site 768492004155 catalytic residue [active] 768492004156 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768492004157 Helix-turn-helix domains; Region: HTH; cl00088 768492004158 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 768492004159 dimerization interface [polypeptide binding]; other site 768492004160 substrate binding pocket [chemical binding]; other site 768492004161 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 768492004162 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 768492004163 Fibronectin type III-like domain; Region: Fn3-like; cl15273 768492004164 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 768492004165 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492004166 DNA-binding site [nucleotide binding]; DNA binding site 768492004167 UTRA domain; Region: UTRA; cl01230 768492004168 Uncharacterized protein conserved in archaea (DUF2099); Region: DUF2099; cl01645 768492004169 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 768492004170 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 768492004171 putative ligand binding residues [chemical binding]; other site 768492004172 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768492004173 ABC-ATPase subunit interface; other site 768492004174 dimer interface [polypeptide binding]; other site 768492004175 putative PBP binding regions; other site 768492004176 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 768492004177 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492004178 Walker A/P-loop; other site 768492004179 ATP binding site [chemical binding]; other site 768492004180 Q-loop/lid; other site 768492004181 ABC transporter signature motif; other site 768492004182 Walker B; other site 768492004183 D-loop; other site 768492004184 H-loop/switch region; other site 768492004185 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 768492004186 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492004187 ParA-like protein; Provisional; Region: PHA02518 768492004188 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 768492004189 P-loop; other site 768492004190 Magnesium ion binding site [ion binding]; other site 768492004191 hypothetical protein; Provisional; Region: PRK11295 768492004192 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 768492004193 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492004194 Coenzyme A binding pocket [chemical binding]; other site 768492004195 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492004196 Helix-turn-helix domains; Region: HTH; cl00088 768492004197 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 768492004198 putative effector binding pocket; other site 768492004199 putative dimerization interface [polypeptide binding]; other site 768492004200 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768492004201 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 768492004202 Autoinducer-2 kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 768492004203 putative N- and C-terminal domain interface [polypeptide binding]; other site 768492004204 putative active site [active] 768492004205 putative MgATP binding site [chemical binding]; other site 768492004206 catalytic site [active] 768492004207 metal binding site [ion binding]; metal-binding site 768492004208 putative carbohydrate binding site [chemical binding]; other site 768492004209 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 768492004210 LysE type translocator; Region: LysE; cl00565 768492004211 Cupin domain; Region: Cupin_2; cl09118 768492004212 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492004213 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768492004214 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492004215 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 768492004216 ATP binding site [chemical binding]; other site 768492004217 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 768492004218 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 768492004219 active site 768492004220 Na/Ca binding site [ion binding]; other site 768492004221 catalytic site [active] 768492004222 Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813 768492004223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 768492004224 TolB amino-terminal domain; Region: TolB_N; cl00639 768492004225 diaminopimelate epimerase; Provisional; Region: PRK13577 768492004226 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 768492004227 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 768492004228 putative transposase OrfB; Reviewed; Region: PHA02517 768492004229 Integrase core domain; Region: rve; cl01316 768492004230 Integrase core domain; Region: rve_3; cl15866 768492004231 Helix-turn-helix domains; Region: HTH; cl00088 768492004232 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 768492004233 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 768492004234 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492004235 Helix-turn-helix domains; Region: HTH; cl00088 768492004236 NMT1-like family; Region: NMT1_2; cl15260 768492004237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492004238 dimer interface [polypeptide binding]; other site 768492004239 conserved gate region; other site 768492004240 putative PBP binding loops; other site 768492004241 ABC-ATPase subunit interface; other site 768492004242 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 768492004243 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 768492004244 Walker A/P-loop; other site 768492004245 ATP binding site [chemical binding]; other site 768492004246 Q-loop/lid; other site 768492004247 ABC transporter signature motif; other site 768492004248 Walker B; other site 768492004249 D-loop; other site 768492004250 H-loop/switch region; other site 768492004251 NIL domain; Region: NIL; cl09633 768492004252 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 768492004253 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768492004254 LysR family transcriptional regulator; Provisional; Region: PRK14997 768492004255 Helix-turn-helix domains; Region: HTH; cl00088 768492004256 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 768492004257 putative effector binding pocket; other site 768492004258 putative dimerization interface [polypeptide binding]; other site 768492004259 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 768492004260 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 768492004261 NADP binding site [chemical binding]; other site 768492004262 dimer interface [polypeptide binding]; other site 768492004263 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 768492004264 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 768492004265 Isochorismatase family; Region: Isochorismatase; pfam00857 768492004266 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 768492004267 catalytic triad [active] 768492004268 conserved cis-peptide bond; other site 768492004269 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492004270 NAD(P) binding site [chemical binding]; other site 768492004271 active site 768492004272 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 768492004273 Helix-turn-helix domains; Region: HTH; cl00088 768492004274 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 768492004275 dimerization interface [polypeptide binding]; other site 768492004276 substrate binding pocket [chemical binding]; other site 768492004277 Helix-turn-helix domains; Region: HTH; cl00088 768492004278 WYL domain; Region: WYL; cl14852 768492004279 D-galactonate transporter; Region: 2A0114; TIGR00893 768492004280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492004281 putative substrate translocation pore; other site 768492004282 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492004283 DNA-binding site [nucleotide binding]; DNA binding site 768492004284 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 768492004285 Transcriptional regulators [Transcription]; Region: GntR; COG1802 768492004286 FCD domain; Region: FCD; cl11656 768492004287 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 768492004288 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 768492004289 putative NAD(P) binding site [chemical binding]; other site 768492004290 catalytic Zn binding site [ion binding]; other site 768492004291 structural Zn binding site [ion binding]; other site 768492004292 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 768492004293 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 768492004294 Walker A/P-loop; other site 768492004295 ATP binding site [chemical binding]; other site 768492004296 Q-loop/lid; other site 768492004297 ABC transporter signature motif; other site 768492004298 Walker B; other site 768492004299 D-loop; other site 768492004300 H-loop/switch region; other site 768492004301 NMT1-like family; Region: NMT1_2; cl15260 768492004302 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 768492004303 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 768492004304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492004305 dimer interface [polypeptide binding]; other site 768492004306 conserved gate region; other site 768492004307 putative PBP binding loops; other site 768492004308 ABC-ATPase subunit interface; other site 768492004309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492004310 dimer interface [polypeptide binding]; other site 768492004311 conserved gate region; other site 768492004312 putative PBP binding loops; other site 768492004313 ABC-ATPase subunit interface; other site 768492004314 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 768492004315 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 768492004316 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 768492004317 allophanate hydrolase; Provisional; Region: PRK08186 768492004318 Amidase; Region: Amidase; cl11426 768492004319 urea carboxylase; Region: urea_carbox; TIGR02712 768492004320 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 768492004321 ATP-grasp domain; Region: ATP-grasp_4; cl03087 768492004322 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 768492004323 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 768492004324 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 768492004325 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 768492004326 carboxyltransferase (CT) interaction site; other site 768492004327 biotinylation site [posttranslational modification]; other site 768492004328 Transcriptional regulators [Transcription]; Region: GntR; COG1802 768492004329 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492004330 DNA-binding site [nucleotide binding]; DNA binding site 768492004331 FCD domain; Region: FCD; cl11656 768492004332 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 768492004333 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 768492004334 putative ligand binding site [chemical binding]; other site 768492004335 HEAT repeats; Region: HEAT_2; pfam13646 768492004336 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 768492004337 TM-ABC transporter signature motif; other site 768492004338 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 768492004339 TM-ABC transporter signature motif; other site 768492004340 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 768492004341 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 768492004342 Walker A/P-loop; other site 768492004343 ATP binding site [chemical binding]; other site 768492004344 Q-loop/lid; other site 768492004345 ABC transporter signature motif; other site 768492004346 Walker B; other site 768492004347 D-loop; other site 768492004348 H-loop/switch region; other site 768492004349 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 768492004350 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 768492004351 Walker A/P-loop; other site 768492004352 ATP binding site [chemical binding]; other site 768492004353 Q-loop/lid; other site 768492004354 ABC transporter signature motif; other site 768492004355 Walker B; other site 768492004356 D-loop; other site 768492004357 H-loop/switch region; other site 768492004358 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 768492004359 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 768492004360 Predicted small integral membrane protein (DUF2165); Region: DUF2165; cl02290 768492004361 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 768492004362 Phosphoesterase family; Region: Phosphoesterase; cl15450 768492004363 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768492004364 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 768492004365 hypothetical protein; Provisional; Region: PRK06185 768492004366 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492004367 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492004368 Helix-turn-helix domains; Region: HTH; cl00088 768492004369 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492004370 dimerization interface [polypeptide binding]; other site 768492004371 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 768492004372 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 768492004373 active site residue [active] 768492004374 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 768492004375 active site residue [active] 768492004376 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 768492004377 nudix motif; other site 768492004378 Protein of unknown function (DUF523); Region: DUF523; cl00733 768492004379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492004380 NAD(P) binding site [chemical binding]; other site 768492004381 active site 768492004382 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 768492004383 Helix-turn-helix domain; Region: HTH_18; pfam12833 768492004384 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768492004385 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492004386 DNA-binding site [nucleotide binding]; DNA binding site 768492004387 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492004388 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492004389 homodimer interface [polypeptide binding]; other site 768492004390 catalytic residue [active] 768492004391 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 768492004392 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 768492004393 putative C-terminal domain interface [polypeptide binding]; other site 768492004394 putative GSH binding site (G-site) [chemical binding]; other site 768492004395 putative dimer interface [polypeptide binding]; other site 768492004396 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 768492004397 putative N-terminal domain interface [polypeptide binding]; other site 768492004398 putative dimer interface [polypeptide binding]; other site 768492004399 putative substrate binding pocket (H-site) [chemical binding]; other site 768492004400 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768492004401 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492004402 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 768492004403 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 768492004404 Isochorismatase family; Region: Isochorismatase; pfam00857 768492004405 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 768492004406 catalytic triad [active] 768492004407 dimer interface [polypeptide binding]; other site 768492004408 conserved cis-peptide bond; other site 768492004409 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492004410 Helix-turn-helix domains; Region: HTH; cl00088 768492004411 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492004412 dimerization interface [polypeptide binding]; other site 768492004413 OsmC-like protein; Region: OsmC; cl00767 768492004414 Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509 768492004415 Fatty acid desaturase; Region: FA_desaturase; pfam00487 768492004416 putative di-iron ligands [ion binding]; other site 768492004417 NMT1-like family; Region: NMT1_2; cl15260 768492004418 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 768492004419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 768492004420 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 768492004421 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 768492004422 Walker A/P-loop; other site 768492004423 ATP binding site [chemical binding]; other site 768492004424 Q-loop/lid; other site 768492004425 ABC transporter signature motif; other site 768492004426 Walker B; other site 768492004427 D-loop; other site 768492004428 H-loop/switch region; other site 768492004429 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 768492004430 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492004431 putative PBP binding loops; other site 768492004432 dimer interface [polypeptide binding]; other site 768492004433 ABC-ATPase subunit interface; other site 768492004434 NMT1-like family; Region: NMT1_2; cl15260 768492004435 short chain dehydrogenase; Provisional; Region: PRK07041 768492004436 classical (c) SDRs; Region: SDR_c; cd05233 768492004437 NAD(P) binding site [chemical binding]; other site 768492004438 active site 768492004439 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492004440 Helix-turn-helix domains; Region: HTH; cl00088 768492004441 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492004442 putative effector binding pocket; other site 768492004443 dimerization interface [polypeptide binding]; other site 768492004444 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 768492004445 EamA-like transporter family; Region: EamA; cl01037 768492004446 EamA-like transporter family; Region: EamA; cl01037 768492004447 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 768492004448 Predicted transcriptional regulator [Transcription]; Region: COG2345 768492004449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492004450 putative substrate translocation pore; other site 768492004451 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768492004452 Cupin domain; Region: Cupin_2; cl09118 768492004453 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768492004454 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492004455 AzlC protein; Region: AzlC; cl00570 768492004456 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 768492004457 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492004458 non-specific DNA binding site [nucleotide binding]; other site 768492004459 salt bridge; other site 768492004460 sequence-specific DNA binding site [nucleotide binding]; other site 768492004461 putative acetyltransferase; Provisional; Region: PRK03624 768492004462 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492004463 Coenzyme A binding pocket [chemical binding]; other site 768492004464 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 768492004465 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 768492004466 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492004467 Coenzyme A binding pocket [chemical binding]; other site 768492004468 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 768492004469 trimer interface [polypeptide binding]; other site 768492004470 eyelet of channel; other site 768492004471 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 768492004472 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 768492004473 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 768492004474 DEAD_2; Region: DEAD_2; pfam06733 768492004475 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492004476 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768492004477 Helix-turn-helix domains; Region: HTH; cl00088 768492004478 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 768492004479 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 768492004480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492004481 putative substrate translocation pore; other site 768492004482 transcriptional regulator; Provisional; Region: PRK10632 768492004483 Helix-turn-helix domains; Region: HTH; cl00088 768492004484 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 768492004485 putative effector binding pocket; other site 768492004486 putative dimerization interface [polypeptide binding]; other site 768492004487 LysE type translocator; Region: LysE; cl00565 768492004488 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 768492004489 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 768492004490 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 768492004491 glycosyl transferase family protein; Provisional; Region: PRK08136 768492004492 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 768492004493 Peptidase M3-like family, a zincin metallopeptidase, includes M3 and M32 families; Region: M3_like; cd06258 768492004494 active site 768492004495 Zn binding site [ion binding]; other site 768492004496 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 768492004497 Flavin Reductases; Region: FlaRed; cl00801 768492004498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 768492004499 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 768492004500 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 768492004501 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 768492004502 Walker A/P-loop; other site 768492004503 ATP binding site [chemical binding]; other site 768492004504 Q-loop/lid; other site 768492004505 ABC transporter signature motif; other site 768492004506 Walker B; other site 768492004507 D-loop; other site 768492004508 H-loop/switch region; other site 768492004509 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768492004510 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492004511 dimer interface [polypeptide binding]; other site 768492004512 conserved gate region; other site 768492004513 putative PBP binding loops; other site 768492004514 ABC-ATPase subunit interface; other site 768492004515 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 768492004516 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492004517 substrate binding pocket [chemical binding]; other site 768492004518 membrane-bound complex binding site; other site 768492004519 hinge residues; other site 768492004520 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 768492004521 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 768492004522 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 768492004523 dimerization interface [polypeptide binding]; other site 768492004524 DPS ferroxidase diiron center [ion binding]; other site 768492004525 ion pore; other site 768492004526 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492004527 Domain of unknown function (DUF386); Region: DUF386; cl01047 768492004528 threonine and homoserine efflux system; Provisional; Region: PRK10532 768492004529 EamA-like transporter family; Region: EamA; cl01037 768492004530 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 768492004531 Predicted amidohydrolase [General function prediction only]; Region: COG0388 768492004532 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_7; cd07585 768492004533 putative active site [active] 768492004534 catalytic triad [active] 768492004535 putative dimer interface [polypeptide binding]; other site 768492004536 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 768492004537 Helix-turn-helix domains; Region: HTH; cl00088 768492004538 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 768492004539 dimerization interface [polypeptide binding]; other site 768492004540 substrate binding pocket [chemical binding]; other site 768492004541 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768492004542 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 768492004543 hypothetical protein; Provisional; Region: PRK09989 768492004544 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 768492004545 Moco binding site; other site 768492004546 metal coordination site [ion binding]; other site 768492004547 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 768492004548 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768492004549 dimerization interface [polypeptide binding]; other site 768492004550 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492004551 dimer interface [polypeptide binding]; other site 768492004552 phosphorylation site [posttranslational modification] 768492004553 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492004554 ATP binding site [chemical binding]; other site 768492004555 Mg2+ binding site [ion binding]; other site 768492004556 G-X-G motif; other site 768492004557 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768492004558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492004559 active site 768492004560 phosphorylation site [posttranslational modification] 768492004561 intermolecular recognition site; other site 768492004562 dimerization interface [polypeptide binding]; other site 768492004563 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768492004564 DNA binding site [nucleotide binding] 768492004565 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 768492004566 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 768492004567 Moco binding site; other site 768492004568 metal coordination site [ion binding]; other site 768492004569 BCCT family transporter; Region: BCCT; cl00569 768492004570 transcriptional regulator BetI; Validated; Region: PRK00767 768492004571 Helix-turn-helix domains; Region: HTH; cl00088 768492004572 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 768492004573 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 768492004574 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 768492004575 tetrameric interface [polypeptide binding]; other site 768492004576 NAD binding site [chemical binding]; other site 768492004577 catalytic residues [active] 768492004578 choline dehydrogenase; Validated; Region: PRK02106 768492004579 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 768492004580 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 768492004581 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 768492004582 active site 768492004583 FMN binding site [chemical binding]; other site 768492004584 substrate binding site [chemical binding]; other site 768492004585 3Fe-4S cluster binding site [ion binding]; other site 768492004586 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 768492004587 Helix-turn-helix domains; Region: HTH; cl00088 768492004588 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768492004589 Fimbrial protein; Region: Fimbrial; cl01416 768492004590 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 768492004591 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 768492004592 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 768492004593 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 768492004594 PapC N-terminal domain; Region: PapC_N; pfam13954 768492004595 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 768492004596 PapC C-terminal domain; Region: PapC_C; pfam13953 768492004597 putative major fimbrial protein SthE; Provisional; Region: PRK15292 768492004598 Fimbrial protein; Region: Fimbrial; cl01416 768492004599 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 768492004600 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492004601 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492004602 Predicted dehydrogenase [General function prediction only]; Region: COG0579 768492004603 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492004604 NAD(P) binding site [chemical binding]; other site 768492004605 active site 768492004606 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492004607 Helix-turn-helix domains; Region: HTH; cl00088 768492004608 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 768492004609 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 768492004610 alkaline phosphatase; Provisional; Region: PRK10518 768492004611 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 768492004612 dimer interface [polypeptide binding]; other site 768492004613 active site 768492004614 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 768492004615 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 768492004616 C-terminal domain interface [polypeptide binding]; other site 768492004617 GSH binding site (G-site) [chemical binding]; other site 768492004618 dimer interface [polypeptide binding]; other site 768492004619 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 768492004620 dimer interface [polypeptide binding]; other site 768492004621 N-terminal domain interface [polypeptide binding]; other site 768492004622 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768492004623 dimerization interface [polypeptide binding]; other site 768492004624 putative DNA binding site [nucleotide binding]; other site 768492004625 putative Zn2+ binding site [ion binding]; other site 768492004626 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 768492004627 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 768492004628 Isochorismatase family; Region: Isochorismatase; pfam00857 768492004629 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 768492004630 catalytic triad [active] 768492004631 dimer interface [polypeptide binding]; other site 768492004632 conserved cis-peptide bond; other site 768492004633 transcriptional regulator; Provisional; Region: PRK10632 768492004634 Helix-turn-helix domains; Region: HTH; cl00088 768492004635 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492004636 putative effector binding pocket; other site 768492004637 dimerization interface [polypeptide binding]; other site 768492004638 AAA domain; Region: AAA_33; pfam13671 768492004639 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492004640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492004641 metabolite-proton symporter; Region: 2A0106; TIGR00883 768492004642 putative substrate translocation pore; other site 768492004643 transcriptional activator TtdR; Provisional; Region: PRK09801 768492004644 Helix-turn-helix domains; Region: HTH; cl00088 768492004645 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492004646 putative effector binding pocket; other site 768492004647 dimerization interface [polypeptide binding]; other site 768492004648 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 768492004649 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492004650 Walker A/P-loop; other site 768492004651 ATP binding site [chemical binding]; other site 768492004652 Q-loop/lid; other site 768492004653 ABC transporter signature motif; other site 768492004654 Walker B; other site 768492004655 D-loop; other site 768492004656 H-loop/switch region; other site 768492004657 ABC transporter; Region: ABC_tran_2; pfam12848 768492004658 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 768492004659 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 768492004660 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 768492004661 ATP binding site [chemical binding]; other site 768492004662 substrate interface [chemical binding]; other site 768492004663 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 768492004664 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 768492004665 dimer interface [polypeptide binding]; other site 768492004666 putative functional site; other site 768492004667 putative MPT binding site; other site 768492004668 Bacterial protein of unknown function (DUF924); Region: DUF924; cl01561 768492004669 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 768492004670 catalytic nucleophile [active] 768492004671 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 768492004672 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 768492004673 Walker A/P-loop; other site 768492004674 ATP binding site [chemical binding]; other site 768492004675 Q-loop/lid; other site 768492004676 ABC transporter signature motif; other site 768492004677 Walker B; other site 768492004678 D-loop; other site 768492004679 H-loop/switch region; other site 768492004680 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768492004681 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 768492004682 Walker A/P-loop; other site 768492004683 ATP binding site [chemical binding]; other site 768492004684 Q-loop/lid; other site 768492004685 ABC transporter signature motif; other site 768492004686 Walker B; other site 768492004687 D-loop; other site 768492004688 H-loop/switch region; other site 768492004689 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768492004690 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 768492004691 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 768492004692 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 768492004693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492004694 dimer interface [polypeptide binding]; other site 768492004695 conserved gate region; other site 768492004696 putative PBP binding loops; other site 768492004697 ABC-ATPase subunit interface; other site 768492004698 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 768492004699 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492004700 dimer interface [polypeptide binding]; other site 768492004701 conserved gate region; other site 768492004702 putative PBP binding loops; other site 768492004703 ABC-ATPase subunit interface; other site 768492004704 Post-segregation antitoxin CcdA; Region: CcdA; cl02188 768492004705 CcdB protein; Region: CcdB; cl03380 768492004706 Predicted esterase [General function prediction only]; Region: COG0627 768492004707 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 768492004708 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 768492004709 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 768492004710 substrate binding site [chemical binding]; other site 768492004711 catalytic Zn binding site [ion binding]; other site 768492004712 NAD binding site [chemical binding]; other site 768492004713 structural Zn binding site [ion binding]; other site 768492004714 dimer interface [polypeptide binding]; other site 768492004715 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492004716 Helix-turn-helix domains; Region: HTH; cl00088 768492004717 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 768492004718 putative dimerization interface [polypeptide binding]; other site 768492004719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492004720 putative substrate translocation pore; other site 768492004721 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 768492004722 active site 768492004723 Predicted membrane protein [Function unknown]; Region: COG2311 768492004724 Protein of unknown function (DUF418); Region: DUF418; cl12135 768492004725 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 768492004726 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492004727 DNA binding site [nucleotide binding] 768492004728 domain linker motif; other site 768492004729 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 768492004730 dimerization interface (closed form) [polypeptide binding]; other site 768492004731 ligand binding site [chemical binding]; other site 768492004732 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 768492004733 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 768492004734 ligand binding site [chemical binding]; other site 768492004735 calcium binding site [ion binding]; other site 768492004736 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 768492004737 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 768492004738 Walker A/P-loop; other site 768492004739 ATP binding site [chemical binding]; other site 768492004740 Q-loop/lid; other site 768492004741 ABC transporter signature motif; other site 768492004742 Walker B; other site 768492004743 D-loop; other site 768492004744 H-loop/switch region; other site 768492004745 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 768492004746 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768492004747 TM-ABC transporter signature motif; other site 768492004748 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 768492004749 putative active site [active] 768492004750 malate dehydrogenase; Provisional; Region: PRK13529 768492004751 Malic enzyme, N-terminal domain; Region: malic; pfam00390 768492004752 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 768492004753 NAD(P) binding site [chemical binding]; other site 768492004754 cytidine deaminase; Provisional; Region: PRK09027 768492004755 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 768492004756 active site 768492004757 catalytic motif [active] 768492004758 Zn binding site [ion binding]; other site 768492004759 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 768492004760 active site 768492004761 catalytic motif [active] 768492004762 Zn binding site [ion binding]; other site 768492004763 LrgB-like family; Region: LrgB; cl00596 768492004764 LrgA family; Region: LrgA; cl00608 768492004765 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768492004766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492004767 putative substrate translocation pore; other site 768492004768 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 768492004769 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 768492004770 putative ligand binding site [chemical binding]; other site 768492004771 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 768492004772 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 768492004773 active site 768492004774 HIGH motif; other site 768492004775 KMSKS motif; other site 768492004776 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 768492004777 tRNA binding surface [nucleotide binding]; other site 768492004778 anticodon binding site; other site 768492004779 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 768492004780 dimer interface [polypeptide binding]; other site 768492004781 putative tRNA-binding site [nucleotide binding]; other site 768492004782 antiporter inner membrane protein; Provisional; Region: PRK11670 768492004783 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 768492004784 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 768492004785 active site 768492004786 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 768492004787 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 768492004788 ATP-binding site [chemical binding]; other site 768492004789 Sugar specificity; other site 768492004790 Pyrimidine base specificity; other site 768492004791 2'-deoxycytidine 5'-triphosphate deaminase (DCD); Region: DCD; pfam06559 768492004792 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 768492004793 trimer interface [polypeptide binding]; other site 768492004794 active site 768492004795 putative assembly protein; Provisional; Region: PRK10833 768492004796 AsmA-like C-terminal region; Region: AsmA_2; cl15864 768492004797 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 768492004798 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 768492004799 Integral membrane protein TerC family; Region: TerC; cl10468 768492004800 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 768492004801 Transporter associated domain; Region: CorC_HlyC; cl08393 768492004802 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 768492004803 active site 768492004804 tetramer interface; other site 768492004805 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 768492004806 active site 768492004807 tetramer interface; other site 768492004808 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 768492004809 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 768492004810 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 768492004811 polysaccharide export protein Wza; Provisional; Region: PRK15078 768492004812 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 768492004813 SLBB domain; Region: SLBB; pfam10531 768492004814 Low molecular weight phosphatase family; Region: LMWPc; cd00115 768492004815 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 768492004816 active site 768492004817 tyrosine kinase; Provisional; Region: PRK11519 768492004818 Chain length determinant protein; Region: Wzz; cl15801 768492004819 Chain length determinant protein; Region: Wzz; cl15801 768492004820 Chain length determinant protein; Region: Wzz; cl15801 768492004821 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492004822 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 768492004823 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 768492004824 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 768492004825 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768492004826 putative ADP-binding pocket [chemical binding]; other site 768492004827 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 768492004828 Bacterial sugar transferase; Region: Bac_transf; cl00939 768492004829 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 768492004830 This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export...; Region: ABCC_Protease_Secretion; cd03246 768492004831 Walker A/P-loop; other site 768492004832 ATP binding site [chemical binding]; other site 768492004833 Q-loop/lid; other site 768492004834 ABC transporter signature motif; other site 768492004835 Walker B; other site 768492004836 D-loop; other site 768492004837 H-loop/switch region; other site 768492004838 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 768492004839 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768492004840 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 768492004841 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 768492004842 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 768492004843 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 768492004844 Substrate binding site; other site 768492004845 Cupin domain; Region: Cupin_2; cl09118 768492004846 phosphomannomutase CpsG; Provisional; Region: PRK15414 768492004847 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 768492004848 active site 768492004849 substrate binding site [chemical binding]; other site 768492004850 metal binding site [ion binding]; metal-binding site 768492004851 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 768492004852 UDP-glucose 4-epimerase; Region: PLN02240 768492004853 NAD binding site [chemical binding]; other site 768492004854 homodimer interface [polypeptide binding]; other site 768492004855 active site 768492004856 substrate binding site [chemical binding]; other site 768492004857 Cupin domain; Region: Cupin_2; cl09118 768492004858 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 768492004859 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 768492004860 NADP binding site [chemical binding]; other site 768492004861 active site 768492004862 putative substrate binding site [chemical binding]; other site 768492004863 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 768492004864 active site 768492004865 ABC-2 type transporter; Region: ABC2_membrane; cl11417 768492004866 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 768492004867 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 768492004868 Walker A/P-loop; other site 768492004869 ATP binding site [chemical binding]; other site 768492004870 Q-loop/lid; other site 768492004871 ABC transporter signature motif; other site 768492004872 Walker B; other site 768492004873 D-loop; other site 768492004874 H-loop/switch region; other site 768492004875 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 768492004876 putative carbohydrate binding site [chemical binding]; other site 768492004877 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 768492004878 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 768492004879 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 768492004880 active site 768492004881 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 768492004882 OpgC protein; Region: OpgC_C; cl00792 768492004883 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492004884 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 768492004885 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 768492004886 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 768492004887 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 768492004888 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 768492004889 metal binding site [ion binding]; metal-binding site 768492004890 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 768492004891 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 768492004892 substrate binding site [chemical binding]; other site 768492004893 glutamase interaction surface [polypeptide binding]; other site 768492004894 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 768492004895 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 768492004896 catalytic residues [active] 768492004897 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 768492004898 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 768492004899 putative active site [active] 768492004900 oxyanion strand; other site 768492004901 catalytic triad [active] 768492004902 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 768492004903 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492004904 active site 768492004905 motif I; other site 768492004906 motif II; other site 768492004907 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 768492004908 putative active site pocket [active] 768492004909 4-fold oligomerization interface [polypeptide binding]; other site 768492004910 metal binding residues [ion binding]; metal-binding site 768492004911 3-fold/trimer interface [polypeptide binding]; other site 768492004912 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 768492004913 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492004914 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492004915 homodimer interface [polypeptide binding]; other site 768492004916 catalytic residue [active] 768492004917 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 768492004918 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 768492004919 NAD binding site [chemical binding]; other site 768492004920 dimerization interface [polypeptide binding]; other site 768492004921 product binding site; other site 768492004922 substrate binding site [chemical binding]; other site 768492004923 zinc binding site [ion binding]; other site 768492004924 catalytic residues [active] 768492004925 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 768492004926 ATP phosphoribosyltransferase; Region: HisG; cl15266 768492004927 HisG, C-terminal domain; Region: HisG_C; cl06867 768492004928 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768492004929 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 768492004930 putative NAD(P) binding site [chemical binding]; other site 768492004931 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492004932 Helix-turn-helix domains; Region: HTH; cl00088 768492004933 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768492004934 dimerization interface [polypeptide binding]; other site 768492004935 Arginase family; Region: Arginase; cl00306 768492004936 Sodium:solute symporter family; Region: SSF; cl00456 768492004937 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 768492004938 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 768492004939 putative acetyltransferase; Provisional; Region: PRK03624 768492004940 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492004941 Coenzyme A binding pocket [chemical binding]; other site 768492004942 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 768492004943 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 768492004944 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 768492004945 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 768492004946 putative C-terminal domain interface [polypeptide binding]; other site 768492004947 putative GSH binding site (G-site) [chemical binding]; other site 768492004948 putative dimer interface [polypeptide binding]; other site 768492004949 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 768492004950 putative N-terminal domain interface [polypeptide binding]; other site 768492004951 putative dimer interface [polypeptide binding]; other site 768492004952 putative substrate binding pocket (H-site) [chemical binding]; other site 768492004953 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 768492004954 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 768492004955 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; cl14733 768492004956 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 768492004957 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 768492004958 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 768492004959 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 768492004960 homodimer interface [polypeptide binding]; other site 768492004961 substrate-cofactor binding pocket; other site 768492004962 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492004963 catalytic residue [active] 768492004964 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 768492004965 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 768492004966 dimer interface [polypeptide binding]; other site 768492004967 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492004968 catalytic residue [active] 768492004969 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 768492004970 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 768492004971 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 768492004972 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 768492004973 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 768492004974 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 768492004975 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 768492004976 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 768492004977 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 768492004978 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 768492004979 Helix-turn-helix domains; Region: HTH; cl00088 768492004980 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 768492004981 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 768492004982 intersubunit interface [polypeptide binding]; other site 768492004983 active site 768492004984 catalytic residue [active] 768492004985 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 768492004986 active site 768492004987 catalytic residues [active] 768492004988 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 768492004989 active site 768492004990 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 768492004991 active site 768492004992 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 768492004993 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 768492004994 secondary substrate binding site; other site 768492004995 primary substrate binding site; other site 768492004996 inhibition loop; other site 768492004997 dimerization interface [polypeptide binding]; other site 768492004998 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 768492004999 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 768492005000 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492005001 catalytic residue [active] 768492005002 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 768492005003 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 768492005004 Fucose-binding lectin II (PA-IIL); Region: PA-IIL; pfam07472 768492005005 putative transporter; Provisional; Region: PRK04972 768492005006 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 768492005007 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 768492005008 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 768492005009 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 768492005010 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 768492005011 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 768492005012 GSH binding site [chemical binding]; other site 768492005013 catalytic residues [active] 768492005014 Protein of unknown function (DUF1418); Region: DUF1418; cl11648 768492005015 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 768492005016 ATP-grasp domain; Region: ATP-grasp_4; cl03087 768492005017 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 768492005018 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 768492005019 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492005020 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 768492005021 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 768492005022 Walker A/P-loop; other site 768492005023 ATP binding site [chemical binding]; other site 768492005024 Q-loop/lid; other site 768492005025 ABC transporter signature motif; other site 768492005026 Walker B; other site 768492005027 D-loop; other site 768492005028 H-loop/switch region; other site 768492005029 TOBE domain; Region: TOBE_2; cl01440 768492005030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492005031 dimer interface [polypeptide binding]; other site 768492005032 conserved gate region; other site 768492005033 putative PBP binding loops; other site 768492005034 ABC-ATPase subunit interface; other site 768492005035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492005036 dimer interface [polypeptide binding]; other site 768492005037 conserved gate region; other site 768492005038 putative PBP binding loops; other site 768492005039 ABC-ATPase subunit interface; other site 768492005040 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 768492005041 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 768492005042 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 768492005043 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492005044 S-adenosylmethionine binding site [chemical binding]; other site 768492005045 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 768492005046 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492005047 substrate binding pocket [chemical binding]; other site 768492005048 membrane-bound complex binding site; other site 768492005049 hinge residues; other site 768492005050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492005051 dimer interface [polypeptide binding]; other site 768492005052 conserved gate region; other site 768492005053 putative PBP binding loops; other site 768492005054 ABC-ATPase subunit interface; other site 768492005055 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768492005056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492005057 dimer interface [polypeptide binding]; other site 768492005058 conserved gate region; other site 768492005059 putative PBP binding loops; other site 768492005060 ABC-ATPase subunit interface; other site 768492005061 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 768492005062 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492005063 substrate binding pocket [chemical binding]; other site 768492005064 membrane-bound complex binding site; other site 768492005065 hinge residues; other site 768492005066 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 768492005067 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492005068 Walker A/P-loop; other site 768492005069 ATP binding site [chemical binding]; other site 768492005070 Q-loop/lid; other site 768492005071 ABC transporter signature motif; other site 768492005072 Walker B; other site 768492005073 D-loop; other site 768492005074 H-loop/switch region; other site 768492005075 putative lipoprotein; Provisional; Region: PRK10533 768492005076 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768492005077 Helix-turn-helix domains; Region: HTH; cl00088 768492005078 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 768492005079 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 768492005080 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 768492005081 Topoisomerase II-associated protein PAT1; Region: PAT1; pfam09770 768492005082 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 768492005083 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 768492005084 amidase catalytic site [active] 768492005085 Zn binding residues [ion binding]; other site 768492005086 substrate binding site [chemical binding]; other site 768492005087 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768492005088 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492005089 NAD(P) binding site [chemical binding]; other site 768492005090 active site 768492005091 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 768492005092 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 768492005093 putative NAD(P) binding site [chemical binding]; other site 768492005094 putative active site [active] 768492005095 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 768492005096 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 768492005097 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 768492005098 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 768492005099 tetramer interface [polypeptide binding]; other site 768492005100 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492005101 catalytic residue [active] 768492005102 pyruvate dehydrogenase; Provisional; Region: PRK09124 768492005103 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 768492005104 PYR/PP interface [polypeptide binding]; other site 768492005105 dimer interface [polypeptide binding]; other site 768492005106 tetramer interface [polypeptide binding]; other site 768492005107 TPP binding site [chemical binding]; other site 768492005108 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 768492005109 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 768492005110 TPP-binding site [chemical binding]; other site 768492005111 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 768492005112 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 768492005113 FAD binding pocket [chemical binding]; other site 768492005114 FAD binding motif [chemical binding]; other site 768492005115 phosphate binding motif [ion binding]; other site 768492005116 beta-alpha-beta structure motif; other site 768492005117 NAD binding pocket [chemical binding]; other site 768492005118 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768492005119 catalytic loop [active] 768492005120 iron binding site [ion binding]; other site 768492005121 hybrid cluster protein; Provisional; Region: PRK05290 768492005122 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768492005123 ACS interaction site; other site 768492005124 CODH interaction site; other site 768492005125 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 768492005126 hybrid metal cluster; other site 768492005127 Membrane protein of unknown function (DUF340); Region: DUF340; cl01028 768492005128 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 768492005129 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 768492005130 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 768492005131 putative active site [active] 768492005132 putative metal-binding site [ion binding]; other site 768492005133 Protein of unknown function (DUF535); Region: DUF535; cl01128 768492005134 macrolide transporter subunit MacA; Provisional; Region: PRK11578 768492005135 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 768492005136 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 768492005137 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 768492005138 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 768492005139 Walker A/P-loop; other site 768492005140 ATP binding site [chemical binding]; other site 768492005141 Q-loop/lid; other site 768492005142 ABC transporter signature motif; other site 768492005143 Walker B; other site 768492005144 D-loop; other site 768492005145 H-loop/switch region; other site 768492005146 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768492005147 FtsX-like permease family; Region: FtsX; cl15850 768492005148 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 768492005149 DNA-binding site [nucleotide binding]; DNA binding site 768492005150 RNA-binding motif; other site 768492005151 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 768492005152 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 768492005153 Clp amino terminal domain; Region: Clp_N; pfam02861 768492005154 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492005155 Walker A motif; other site 768492005156 ATP binding site [chemical binding]; other site 768492005157 Walker B motif; other site 768492005158 arginine finger; other site 768492005159 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492005160 Walker A motif; other site 768492005161 ATP binding site [chemical binding]; other site 768492005162 Walker B motif; other site 768492005163 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 768492005164 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 768492005165 rRNA binding site [nucleotide binding]; other site 768492005166 predicted 30S ribosome binding site; other site 768492005167 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 768492005168 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 768492005169 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492005170 Walker A/P-loop; other site 768492005171 ATP binding site [chemical binding]; other site 768492005172 Q-loop/lid; other site 768492005173 ABC transporter signature motif; other site 768492005174 Walker B; other site 768492005175 D-loop; other site 768492005176 H-loop/switch region; other site 768492005177 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 768492005178 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 768492005179 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492005180 Q-loop/lid; other site 768492005181 ABC transporter signature motif; other site 768492005182 Walker B; other site 768492005183 D-loop; other site 768492005184 H-loop/switch region; other site 768492005185 glutathionine S-transferase; Provisional; Region: PRK10542 768492005186 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 768492005187 C-terminal domain interface [polypeptide binding]; other site 768492005188 GSH binding site (G-site) [chemical binding]; other site 768492005189 dimer interface [polypeptide binding]; other site 768492005190 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 768492005191 dimer interface [polypeptide binding]; other site 768492005192 N-terminal domain interface [polypeptide binding]; other site 768492005193 substrate binding pocket (H-site) [chemical binding]; other site 768492005194 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492005195 Helix-turn-helix domains; Region: HTH; cl00088 768492005196 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768492005197 dimerization interface [polypeptide binding]; other site 768492005198 thioredoxin reductase; Provisional; Region: PRK10262 768492005199 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768492005200 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 768492005201 Helix-turn-helix domains; Region: HTH; cl00088 768492005202 AsnC family; Region: AsnC_trans_reg; pfam01037 768492005203 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 768492005204 DNA translocase FtsK; Provisional; Region: PRK10263 768492005205 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492005206 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 768492005207 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 768492005208 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 768492005209 recombination factor protein RarA; Reviewed; Region: PRK13342 768492005210 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492005211 Walker A motif; other site 768492005212 ATP binding site [chemical binding]; other site 768492005213 Walker B motif; other site 768492005214 arginine finger; other site 768492005215 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 768492005216 seryl-tRNA synthetase; Provisional; Region: PRK05431 768492005217 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 768492005218 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 768492005219 dimer interface [polypeptide binding]; other site 768492005220 active site 768492005221 motif 1; other site 768492005222 motif 2; other site 768492005223 motif 3; other site 768492005224 LysE type translocator; Region: LysE; cl00565 768492005225 Cupin domain; Region: Cupin_2; cl09118 768492005226 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768492005227 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492005228 Protein of unknown function (DUF419); Region: DUF419; cl15265 768492005229 putative MFS family transporter protein; Provisional; Region: PRK03633 768492005230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492005231 putative substrate translocation pore; other site 768492005232 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 768492005233 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768492005234 FeS/SAM binding site; other site 768492005235 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 768492005236 Pyruvate formate lyase 1; Region: PFL1; cd01678 768492005237 coenzyme A binding site [chemical binding]; other site 768492005238 active site 768492005239 catalytic residues [active] 768492005240 glycine loop; other site 768492005241 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 768492005242 Uncharacterized conserved protein [Function unknown]; Region: COG1944 768492005243 bacteriocin biosynthesis docking scaffold, SagD family; Region: docking_ocin; cl09146 768492005244 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 768492005245 homodimer interface [polypeptide binding]; other site 768492005246 active site 768492005247 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 768492005248 homodimer interface [polypeptide binding]; other site 768492005249 substrate-cofactor binding pocket; other site 768492005250 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492005251 catalytic residue [active] 768492005252 3-phosphoshikimate 1-carboxyvinyltransferase; Region: PLN02338 768492005253 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 768492005254 hinge; other site 768492005255 active site 768492005256 cytidylate kinase; Provisional; Region: cmk; PRK00023 768492005257 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 768492005258 CMP-binding site; other site 768492005259 The sites determining sugar specificity; other site 768492005260 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 768492005261 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 768492005262 RNA binding site [nucleotide binding]; other site 768492005263 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 768492005264 RNA binding site [nucleotide binding]; other site 768492005265 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec4; cd05689 768492005266 RNA binding site [nucleotide binding]; other site 768492005267 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec5; cd05690 768492005268 RNA binding site [nucleotide binding]; other site 768492005269 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691 768492005270 RNA binding site [nucleotide binding]; other site 768492005271 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 768492005272 IHF dimer interface [polypeptide binding]; other site 768492005273 IHF - DNA interface [nucleotide binding]; other site 768492005274 ComEC family competence protein; Provisional; Region: PRK11539 768492005275 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 768492005276 Competence protein; Region: Competence; cl00471 768492005277 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 768492005278 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 768492005279 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 768492005280 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 768492005281 Walker A/P-loop; other site 768492005282 ATP binding site [chemical binding]; other site 768492005283 Q-loop/lid; other site 768492005284 ABC transporter signature motif; other site 768492005285 Walker B; other site 768492005286 D-loop; other site 768492005287 H-loop/switch region; other site 768492005288 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 768492005289 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 768492005290 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 768492005291 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 768492005292 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 768492005293 DNA-binding site [nucleotide binding]; DNA binding site 768492005294 RNA-binding motif; other site 768492005295 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 768492005296 DNA-binding site [nucleotide binding]; DNA binding site 768492005297 RNA-binding motif; other site 768492005298 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 768492005299 Trm112p-like protein; Region: Trm112p; cl01066 768492005300 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 768492005301 Ligand binding site; other site 768492005302 oligomer interface; other site 768492005303 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 768492005304 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 768492005305 putative active site [active] 768492005306 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 768492005307 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492005308 S-adenosylmethionine binding site [chemical binding]; other site 768492005309 KicB killing factor; Region: KicB; cl11468 768492005310 MukE-like family; Region: MukE; cl11471 768492005311 cell division protein MukB; Provisional; Region: mukB; PRK04863 768492005312 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492005313 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 768492005314 murein L,D-transpeptidase; Provisional; Region: PRK10594 768492005315 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 768492005316 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 768492005317 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 768492005318 Peptidase M15; Region: Peptidase_M15_3; cl01194 768492005319 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 768492005320 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 768492005321 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 768492005322 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492005323 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492005324 homodimer interface [polypeptide binding]; other site 768492005325 catalytic residue [active] 768492005326 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 768492005327 trimer interface [polypeptide binding]; other site 768492005328 eyelet of channel; other site 768492005329 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 768492005330 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 768492005331 putative dimer interface [polypeptide binding]; other site 768492005332 putative anticodon binding site; other site 768492005333 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 768492005334 homodimer interface [polypeptide binding]; other site 768492005335 motif 1; other site 768492005336 motif 2; other site 768492005337 active site 768492005338 motif 3; other site 768492005339 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 768492005340 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 768492005341 active site 768492005342 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768492005343 metal binding site [ion binding]; metal-binding site 768492005344 active site 768492005345 I-site; other site 768492005346 aminopeptidase N; Provisional; Region: pepN; PRK14015 768492005347 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 768492005348 active site 768492005349 Zn binding site [ion binding]; other site 768492005350 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 768492005351 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 768492005352 Walker A/P-loop; other site 768492005353 ATP binding site [chemical binding]; other site 768492005354 Q-loop/lid; other site 768492005355 ABC transporter signature motif; other site 768492005356 Walker B; other site 768492005357 D-loop; other site 768492005358 H-loop/switch region; other site 768492005359 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 768492005360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492005361 dimer interface [polypeptide binding]; other site 768492005362 conserved gate region; other site 768492005363 putative PBP binding loops; other site 768492005364 ABC-ATPase subunit interface; other site 768492005365 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 768492005366 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 768492005367 active site 768492005368 dimer interface [polypeptide binding]; other site 768492005369 non-prolyl cis peptide bond; other site 768492005370 insertion regions; other site 768492005371 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492005372 substrate binding pocket [chemical binding]; other site 768492005373 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 768492005374 membrane-bound complex binding site; other site 768492005375 hinge residues; other site 768492005376 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 768492005377 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 768492005378 quinone interaction residues [chemical binding]; other site 768492005379 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 768492005380 active site 768492005381 catalytic residues [active] 768492005382 FMN binding site [chemical binding]; other site 768492005383 substrate binding site [chemical binding]; other site 768492005384 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 768492005385 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 768492005386 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 768492005387 MOSC domain; Region: MOSC; pfam03473 768492005388 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768492005389 catalytic loop [active] 768492005390 iron binding site [ion binding]; other site 768492005391 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 768492005392 THUMP domain; Region: THUMP; cl12076 768492005393 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 768492005394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492005395 S-adenosylmethionine binding site [chemical binding]; other site 768492005396 ABC transporter ATPase component; Reviewed; Region: PRK11147 768492005397 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492005398 Walker A/P-loop; other site 768492005399 ATP binding site [chemical binding]; other site 768492005400 Q-loop/lid; other site 768492005401 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 768492005402 ABC transporter; Region: ABC_tran_2; pfam12848 768492005403 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 768492005404 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 768492005405 Paraquat-inducible protein A; Region: PqiA; pfam04403 768492005406 Paraquat-inducible protein A; Region: PqiA; pfam04403 768492005407 paraquat-inducible protein B; Provisional; Region: PRK10807 768492005408 mce related protein; Region: MCE; pfam02470 768492005409 mce related protein; Region: MCE; pfam02470 768492005410 mce related protein; Region: MCE; pfam02470 768492005411 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 768492005412 Protein of unknown function (DUF330); Region: DUF330; cl01135 768492005413 Ribosome modulation factor; Region: RMF; cl01207 768492005414 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 768492005415 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 768492005416 dimer interface [polypeptide binding]; other site 768492005417 active site 768492005418 Helix-turn-helix domains; Region: HTH; cl00088 768492005419 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 768492005420 active site 2 [active] 768492005421 dimer interface [polypeptide binding]; other site 768492005422 active site 1 [active] 768492005423 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 768492005424 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 768492005425 Organiser of macrodomain of Terminus of chromosome; Region: MatP; cl11476 768492005426 outer membrane protein A; Reviewed; Region: PRK10808 768492005427 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 768492005428 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 768492005429 ligand binding site [chemical binding]; other site 768492005430 Cell division inhibitor SulA; Region: SulA; cl01880 768492005431 TfoX N-terminal domain; Region: TfoX_N; cl01167 768492005432 TfoX N-terminal domain; Region: TfoX_N; cl01167 768492005433 hypothetical membrane protein, TIGR01666; Region: YCCS 768492005434 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 768492005435 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 768492005436 hypothetical protein; Provisional; Region: PRK11770 768492005437 Domain of unknown function (DUF307); Region: DUF307; pfam03733 768492005438 Domain of unknown function (DUF307); Region: DUF307; pfam03733 768492005439 DNA helicase IV; Provisional; Region: helD; PRK11054 768492005440 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 768492005441 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492005442 Family description; Region: UvrD_C_2; cl15862 768492005443 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 768492005444 active site 768492005445 dimer interfaces [polypeptide binding]; other site 768492005446 catalytic residues [active] 768492005447 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 768492005448 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492005449 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; cl01548 768492005450 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 768492005451 PUA domain; Region: PUA; cl00607 768492005452 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 768492005453 putative RNA binding site [nucleotide binding]; other site 768492005454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492005455 S-adenosylmethionine binding site [chemical binding]; other site 768492005456 Acylphosphatase; Region: Acylphosphatase; cl00551 768492005457 DsrC like protein; Region: DsrC; cl01101 768492005458 YccA-like proteins; Region: YccA_like; cd10433 768492005459 Phospholipid methyltransferase; Region: PEMT; cl00763 768492005460 hypothetical protein; Provisional; Region: PRK14851 768492005461 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 768492005462 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 768492005463 REDY-like protein HapK; Region: HapK; pfam11639 768492005464 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 768492005465 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 768492005466 active site 768492005467 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 768492005468 AMP-binding enzyme; Region: AMP-binding; cl15778 768492005469 AMP-binding enzyme; Region: AMP-binding; cl15778 768492005470 polyketide-type polyunsaturated fatty acid synthase PfaA; Region: omega_3_PfaA; TIGR02813 768492005471 Phosphopantetheine attachment site; Region: PP-binding; cl09936 768492005472 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 768492005473 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768492005474 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492005475 catalytic residue [active] 768492005476 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 768492005477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492005478 S-adenosylmethionine binding site [chemical binding]; other site 768492005479 Predicted dehydrogenase [General function prediction only]; Region: COG5322 768492005480 acetylornithine aminotransferase; Provisional; Region: PRK02627 768492005481 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768492005482 inhibitor-cofactor binding pocket; inhibition site 768492005483 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492005484 catalytic residue [active] 768492005485 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 768492005486 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 768492005487 TPP-binding site [chemical binding]; other site 768492005488 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 768492005489 phosphoenolpyruvate synthase; Validated; Region: PRK06241 768492005490 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 768492005491 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 768492005492 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492005493 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 768492005494 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 768492005495 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 768492005496 active site 768492005497 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 768492005498 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 768492005499 active site 768492005500 substrate binding site [chemical binding]; other site 768492005501 Mg2+ binding site [ion binding]; other site 768492005502 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 768492005503 LysE type translocator; Region: LysE; cl00565 768492005504 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 768492005505 Helix-turn-helix domains; Region: HTH; cl00088 768492005506 The C-terminal substrate binding domain of LysR-type transcriptional regulator TrpI, which is involved in control of tryptophan synthesis, contains type 2 periplasmic binding fold; Region: PBP2_TrpI; cd08482 768492005507 putative dimerization interface [polypeptide binding]; other site 768492005508 putative substrate binding pocket [chemical binding]; other site 768492005509 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492005510 non-specific DNA binding site [nucleotide binding]; other site 768492005511 salt bridge; other site 768492005512 sequence-specific DNA binding site [nucleotide binding]; other site 768492005513 Cupin domain; Region: Cupin_2; cl09118 768492005514 EamA-like transporter family; Region: EamA; cl01037 768492005515 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 768492005516 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 768492005517 Flavin Reductases; Region: FlaRed; cl00801 768492005518 pyrimidine utilization protein D; Region: RutD; TIGR03611 768492005519 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 768492005520 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 768492005521 homotrimer interaction site [polypeptide binding]; other site 768492005522 putative active site [active] 768492005523 Isochorismatase family; Region: Isochorismatase; pfam00857 768492005524 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 768492005525 catalytic triad [active] 768492005526 conserved cis-peptide bond; other site 768492005527 pyrimidine utilization protein A; Region: RutA; TIGR03612 768492005528 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 768492005529 active site 768492005530 dimer interface [polypeptide binding]; other site 768492005531 non-prolyl cis peptide bond; other site 768492005532 insertion regions; other site 768492005533 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 768492005534 Helix-turn-helix domains; Region: HTH; cl00088 768492005535 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 768492005536 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 768492005537 Gram-negative bacterial tonB protein; Region: TonB; cl10048 768492005538 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 768492005539 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 768492005540 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768492005541 substrate binding site [chemical binding]; other site 768492005542 oxyanion hole (OAH) forming residues; other site 768492005543 trimer interface [polypeptide binding]; other site 768492005544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492005545 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768492005546 putative substrate translocation pore; other site 768492005547 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 768492005548 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768492005549 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492005550 catalytic residue [active] 768492005551 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 768492005552 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 768492005553 dimer interface [polypeptide binding]; other site 768492005554 active site 768492005555 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 768492005556 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492005557 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768492005558 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768492005559 transcriptional regulator TraR; Provisional; Region: PRK13870 768492005560 Autoinducer binding domain; Region: Autoind_bind; pfam03472 768492005561 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492005562 DNA binding residues [nucleotide binding] 768492005563 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 768492005564 Ligand Binding Site [chemical binding]; other site 768492005565 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 768492005566 amino acid transporter; Region: 2A0306; TIGR00909 768492005567 Spore germination protein; Region: Spore_permease; cl15802 768492005568 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 768492005569 dimer interface [polypeptide binding]; other site 768492005570 NADP binding site [chemical binding]; other site 768492005571 catalytic residues [active] 768492005572 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 768492005573 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 768492005574 inhibitor site; inhibition site 768492005575 active site 768492005576 dimer interface [polypeptide binding]; other site 768492005577 catalytic residue [active] 768492005578 PAS fold; Region: PAS_4; pfam08448 768492005579 Helix-turn-helix domain; Region: HTH_18; pfam12833 768492005580 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492005581 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 768492005582 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 768492005583 FAD dependent oxidoreductase; Region: DAO; pfam01266 768492005584 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 768492005585 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 768492005586 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 768492005587 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 768492005588 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 768492005589 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 768492005590 GlpM protein; Region: GlpM; cl01212 768492005591 Protein of unknown function (DUF2594); Region: DUF2594; cl11678 768492005592 response regulator; Provisional; Region: PRK09483 768492005593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492005594 active site 768492005595 phosphorylation site [posttranslational modification] 768492005596 intermolecular recognition site; other site 768492005597 dimerization interface [polypeptide binding]; other site 768492005598 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492005599 DNA binding residues [nucleotide binding] 768492005600 dimerization interface [polypeptide binding]; other site 768492005601 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 768492005602 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 768492005603 GIY-YIG motif/motif A; other site 768492005604 active site 768492005605 catalytic site [active] 768492005606 putative DNA binding site [nucleotide binding]; other site 768492005607 metal binding site [ion binding]; metal-binding site 768492005608 UvrB/uvrC motif; Region: UVR; pfam02151 768492005609 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 768492005610 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 768492005611 phosphoethanolamine transferase; Provisional; Region: PRK11560 768492005612 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 768492005613 Sulfatase; Region: Sulfatase; cl10460 768492005614 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 768492005615 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 768492005616 proline/glycine betaine transporter; Provisional; Region: PRK10642 768492005617 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492005618 putative substrate translocation pore; other site 768492005619 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 768492005620 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 768492005621 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 768492005622 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 768492005623 Walker A/P-loop; other site 768492005624 ATP binding site [chemical binding]; other site 768492005625 Q-loop/lid; other site 768492005626 ABC transporter signature motif; other site 768492005627 Walker B; other site 768492005628 D-loop; other site 768492005629 H-loop/switch region; other site 768492005630 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768492005631 FtsX-like permease family; Region: FtsX; cl15850 768492005632 macrolide transporter subunit MacA; Provisional; Region: PRK11578 768492005633 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 768492005634 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 768492005635 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 768492005636 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 768492005637 GIY-YIG motif/motif A; other site 768492005638 active site 768492005639 catalytic site [active] 768492005640 putative DNA binding site [nucleotide binding]; other site 768492005641 metal binding site [ion binding]; metal-binding site 768492005642 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 768492005643 potassium/proton antiporter; Reviewed; Region: PRK05326 768492005644 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 768492005645 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 768492005646 Transporter associated domain; Region: CorC_HlyC; cl08393 768492005647 OpgC protein; Region: OpgC_C; cl00792 768492005648 Acyltransferase family; Region: Acyl_transf_3; pfam01757 768492005649 OpgC protein; Region: OpgC_C; cl00792 768492005650 Acyltransferase family; Region: Acyl_transf_3; pfam01757 768492005651 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 768492005652 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 768492005653 Membrane glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: MdoH; COG2943 768492005654 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 768492005655 Ligand binding site; other site 768492005656 DXD motif; other site 768492005657 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 768492005658 MsyB protein; Region: MsyB; cl08181 768492005659 2-isopropylmalate synthase; Validated; Region: PRK03739 768492005660 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 768492005661 active site 768492005662 catalytic residues [active] 768492005663 metal binding site [ion binding]; metal-binding site 768492005664 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 768492005665 Cupin domain; Region: Cupin_2; cl09118 768492005666 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768492005667 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492005668 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768492005669 dimerization interface [polypeptide binding]; other site 768492005670 putative DNA binding site [nucleotide binding]; other site 768492005671 putative Zn2+ binding site [ion binding]; other site 768492005672 Predicted transporter component [General function prediction only]; Region: COG2391 768492005673 Sulphur transport; Region: Sulf_transp; cl01018 768492005674 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768492005675 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 768492005676 active site 768492005677 metal binding site [ion binding]; metal-binding site 768492005678 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 768492005679 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 768492005680 drug efflux system protein MdtG; Provisional; Region: PRK09874 768492005681 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492005682 putative substrate translocation pore; other site 768492005683 YCII-related domain; Region: YCII; cl00999 768492005684 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 768492005685 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 768492005686 putative acyl-acceptor binding pocket; other site 768492005687 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 768492005688 active site 768492005689 FMN binding site [chemical binding]; other site 768492005690 substrate binding site [chemical binding]; other site 768492005691 homotetramer interface [polypeptide binding]; other site 768492005692 catalytic residue [active] 768492005693 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 768492005694 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 768492005695 active site residue [active] 768492005696 YceI-like domain; Region: YceI; cl01001 768492005697 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 768492005698 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 768492005699 Domain of unknown function DUF20; Region: UPF0118; pfam01594 768492005700 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 768492005701 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492005702 DNA binding residues [nucleotide binding] 768492005703 dimerization interface [polypeptide binding]; other site 768492005704 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 768492005705 BssS protein family; Region: BssS; cl08210 768492005706 DinI-like family; Region: DinI; cl11630 768492005707 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 768492005708 active site 768492005709 substrate binding pocket [chemical binding]; other site 768492005710 dimer interface [polypeptide binding]; other site 768492005711 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 768492005712 ribonuclease E; Reviewed; Region: rne; PRK10811 768492005713 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 768492005714 homodimer interface [polypeptide binding]; other site 768492005715 oligonucleotide binding site [chemical binding]; other site 768492005716 ribonuclease E; Reviewed; Region: rne; PRK10811 768492005717 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 768492005718 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 768492005719 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 768492005720 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 768492005721 active site 768492005722 Maf-like protein; Region: Maf; pfam02545 768492005723 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 768492005724 active site 768492005725 dimer interface [polypeptide binding]; other site 768492005726 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 768492005727 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 768492005728 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 768492005729 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 768492005730 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 768492005731 dimer interface [polypeptide binding]; other site 768492005732 active site 768492005733 CoA binding pocket [chemical binding]; other site 768492005734 Acyl transferase domain; Region: Acyl_transf_1; cl08282 768492005735 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 768492005736 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 768492005737 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 768492005738 NAD(P) binding site [chemical binding]; other site 768492005739 homotetramer interface [polypeptide binding]; other site 768492005740 homodimer interface [polypeptide binding]; other site 768492005741 active site 768492005742 Phosphopantetheine attachment site; Region: PP-binding; cl09936 768492005743 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 768492005744 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 768492005745 dimer interface [polypeptide binding]; other site 768492005746 active site 768492005747 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 768492005748 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492005749 catalytic residue [active] 768492005750 YceG-like family; Region: YceG; pfam02618 768492005751 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 768492005752 dimerization interface [polypeptide binding]; other site 768492005753 thymidylate kinase; Validated; Region: tmk; PRK00698 768492005754 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 768492005755 TMP-binding site; other site 768492005756 ATP-binding site [chemical binding]; other site 768492005757 DNA polymerase III subunit delta'; Validated; Region: PRK07993 768492005758 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 768492005759 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 768492005760 active site 768492005761 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 768492005762 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 768492005763 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768492005764 active site turn [active] 768492005765 phosphorylation site [posttranslational modification] 768492005766 manganese transport regulator MntR; Provisional; Region: PRK11050 768492005767 Helix-turn-helix domains; Region: HTH; cl00088 768492005768 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 768492005769 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 768492005770 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 768492005771 Bacterial SH3 domain; Region: SH3_3; cl02551 768492005772 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 768492005773 classical (c) SDRs; Region: SDR_c; cd05233 768492005774 NAD(P) binding site [chemical binding]; other site 768492005775 active site 768492005776 Helix-turn-helix domains; Region: HTH; cl00088 768492005777 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768492005778 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492005779 substrate binding pocket [chemical binding]; other site 768492005780 membrane-bound complex binding site; other site 768492005781 hinge residues; other site 768492005782 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 768492005783 nucleotide binding site/active site [active] 768492005784 HIT family signature motif; other site 768492005785 catalytic residue [active] 768492005786 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 768492005787 putative dimer interface [polypeptide binding]; other site 768492005788 TolB amino-terminal domain; Region: TolB_N; cl00639 768492005789 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 768492005790 active site 768492005791 substrate binding site [chemical binding]; other site 768492005792 ATP binding site [chemical binding]; other site 768492005793 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 768492005794 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 768492005795 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 768492005796 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768492005797 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 768492005798 Predicted transcriptional regulator [Transcription]; Region: COG1959 768492005799 Helix-turn-helix domains; Region: HTH; cl00088 768492005800 Helix-turn-helix domains; Region: HTH; cl00088 768492005801 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 768492005802 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 768492005803 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 768492005804 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 768492005805 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 768492005806 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492005807 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492005808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492005809 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 768492005810 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 768492005811 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 768492005812 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492005813 putative hydrolase; Validated; Region: PRK09248 768492005814 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 768492005815 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 768492005816 putative metal binding site [ion binding]; other site 768492005817 protease 2; Provisional; Region: PRK10115 768492005818 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 768492005819 exodeoxyribonuclease X; Provisional; Region: PRK07983 768492005820 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 768492005821 active site 768492005822 catalytic site [active] 768492005823 substrate binding site [chemical binding]; other site 768492005824 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 768492005825 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 768492005826 DNA polymerase III, theta subunit; Region: DNA_pol3_theta; cl11635 768492005827 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 768492005828 Ferritin-like domain; Region: Ferritin; pfam00210 768492005829 ferroxidase diiron center [ion binding]; other site 768492005830 Bacterial Ig-like domain; Region: Big_5; cl01012 768492005831 Copper resistance protein D; Region: CopD; cl00563 768492005832 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 768492005833 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768492005834 Isochorismatase family; Region: Isochorismatase; pfam00857 768492005835 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 768492005836 catalytic triad [active] 768492005837 conserved cis-peptide bond; other site 768492005838 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 768492005839 putative transposase OrfB; Reviewed; Region: PHA02517 768492005840 Integrase core domain; Region: rve; cl01316 768492005841 Integrase core domain; Region: rve_3; cl15866 768492005842 Helix-turn-helix domains; Region: HTH; cl00088 768492005843 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 768492005844 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 768492005845 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492005846 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 768492005847 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 768492005848 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 768492005849 transcriptional regulator; Provisional; Region: PRK10632 768492005850 Helix-turn-helix domains; Region: HTH; cl00088 768492005851 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492005852 dimerization interface [polypeptide binding]; other site 768492005853 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 768492005854 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 768492005855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492005856 active site 768492005857 phosphorylation site [posttranslational modification] 768492005858 intermolecular recognition site; other site 768492005859 dimerization interface [polypeptide binding]; other site 768492005860 sensory histidine kinase DcuS; Provisional; Region: PRK11086 768492005861 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492005862 ATP binding site [chemical binding]; other site 768492005863 Mg2+ binding site [ion binding]; other site 768492005864 G-X-G motif; other site 768492005865 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 768492005866 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 768492005867 putative active site; other site 768492005868 catalytic residue [active] 768492005869 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 768492005870 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 768492005871 putative ligand binding site [chemical binding]; other site 768492005872 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 768492005873 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 768492005874 Walker A/P-loop; other site 768492005875 ATP binding site [chemical binding]; other site 768492005876 Q-loop/lid; other site 768492005877 ABC transporter signature motif; other site 768492005878 Walker B; other site 768492005879 D-loop; other site 768492005880 H-loop/switch region; other site 768492005881 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 768492005882 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768492005883 TM-ABC transporter signature motif; other site 768492005884 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 768492005885 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 768492005886 putative ligand binding site [chemical binding]; other site 768492005887 Right handed beta helix region; Region: Beta_helix; pfam13229 768492005888 Right handed beta helix region; Region: Beta_helix; pfam13229 768492005889 NMT1-like family; Region: NMT1_2; cl15260 768492005890 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 768492005891 putative kinase; Provisional; Region: PRK09954 768492005892 Helix-turn-helix domains; Region: HTH; cl00088 768492005893 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 768492005894 substrate binding site [chemical binding]; other site 768492005895 ATP binding site [chemical binding]; other site 768492005896 Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983 768492005897 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 768492005898 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 768492005899 Nucleoside recognition; Region: Gate; cl00486 768492005900 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 768492005901 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 768492005902 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768492005903 dimerization interface [polypeptide binding]; other site 768492005904 putative DNA binding site [nucleotide binding]; other site 768492005905 putative Zn2+ binding site [ion binding]; other site 768492005906 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 768492005907 Clp protease; Region: CLP_protease; pfam00574 768492005908 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 768492005909 oligomer interface [polypeptide binding]; other site 768492005910 active site residues [active] 768492005911 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768492005912 PAS domain; Region: PAS_9; pfam13426 768492005913 putative active site [active] 768492005914 heme pocket [chemical binding]; other site 768492005915 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768492005916 metal binding site [ion binding]; metal-binding site 768492005917 active site 768492005918 I-site; other site 768492005919 GTP-binding protein YchF; Reviewed; Region: PRK09601 768492005920 YchF GTPase; Region: YchF; cd01900 768492005921 G1 box; other site 768492005922 GTP/Mg2+ binding site [chemical binding]; other site 768492005923 Switch I region; other site 768492005924 G2 box; other site 768492005925 Switch II region; other site 768492005926 G3 box; other site 768492005927 G4 box; other site 768492005928 G5 box; other site 768492005929 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 768492005930 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 768492005931 Sulfate transporter family; Region: Sulfate_transp; cl15842 768492005932 Sulfate transporter family; Region: Sulfate_transp; cl15842 768492005933 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 768492005934 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 768492005935 putative active site [active] 768492005936 catalytic residue [active] 768492005937 Protein of unknown function (DUF2583); Region: DUF2583; cl11676 768492005938 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 768492005939 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 768492005940 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768492005941 active site 768492005942 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 768492005943 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 768492005944 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 768492005945 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 768492005946 Chitin binding domain; Region: Chitin_bind_3; cl03871 768492005947 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 768492005948 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 768492005949 tRNA; other site 768492005950 putative tRNA binding site [nucleotide binding]; other site 768492005951 putative NADP binding site [chemical binding]; other site 768492005952 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 768492005953 peptide chain release factor 1; Validated; Region: prfA; PRK00591 768492005954 RF-1 domain; Region: RF-1; cl02875 768492005955 RF-1 domain; Region: RF-1; cl02875 768492005956 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 768492005957 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492005958 Invasion gene expression up-regulator, SirB; Region: SirB; cl01184 768492005959 hypothetical protein; Provisional; Region: PRK10941 768492005960 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 768492005961 NeuB family; Region: NeuB; cl00496 768492005962 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 768492005963 putative transporter; Provisional; Region: PRK11660 768492005964 Sulfate transporter family; Region: Sulfate_transp; cl15842 768492005965 Sulfate transporter family; Region: Sulfate_transp; cl15842 768492005966 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 768492005967 Domain of unknown function (DUF336); Region: DUF336; cl01249 768492005968 transcription-repair coupling factor; Provisional; Region: PRK10689 768492005969 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 768492005970 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768492005971 ATP binding site [chemical binding]; other site 768492005972 putative Mg++ binding site [ion binding]; other site 768492005973 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768492005974 nucleotide binding region [chemical binding]; other site 768492005975 ATP-binding site [chemical binding]; other site 768492005976 TRCF domain; Region: TRCF; cl04088 768492005977 serine racemase; Region: PLN02970 768492005978 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 768492005979 tetramer interface [polypeptide binding]; other site 768492005980 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492005981 catalytic residue [active] 768492005982 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 768492005983 YheO-like PAS domain; Region: PAS_6; pfam08348 768492005984 Helix-turn-helix domains; Region: HTH; cl00088 768492005985 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 768492005986 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768492005987 FtsX-like permease family; Region: FtsX; cl15850 768492005988 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 768492005989 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 768492005990 Walker A/P-loop; other site 768492005991 ATP binding site [chemical binding]; other site 768492005992 Q-loop/lid; other site 768492005993 ABC transporter signature motif; other site 768492005994 Walker B; other site 768492005995 D-loop; other site 768492005996 H-loop/switch region; other site 768492005997 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 768492005998 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768492005999 FtsX-like permease family; Region: FtsX; cl15850 768492006000 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 768492006001 fructokinase; Reviewed; Region: PRK09557 768492006002 NAD-dependent deacetylase; Provisional; Region: PRK00481 768492006003 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 768492006004 NAD+ binding site [chemical binding]; other site 768492006005 substrate binding site [chemical binding]; other site 768492006006 Zn binding site [ion binding]; other site 768492006007 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 768492006008 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768492006009 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768492006010 putative active site [active] 768492006011 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 768492006012 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492006013 NAD(P) binding site [chemical binding]; other site 768492006014 LDH/MDH dimer interface [polypeptide binding]; other site 768492006015 substrate binding site [chemical binding]; other site 768492006016 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 768492006017 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 768492006018 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768492006019 active site turn [active] 768492006020 phosphorylation site [posttranslational modification] 768492006021 peptidase T; Region: peptidase-T; TIGR01882 768492006022 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 768492006023 metal binding site [ion binding]; metal-binding site 768492006024 dimer interface [polypeptide binding]; other site 768492006025 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 768492006026 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 768492006027 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768492006028 Helix-turn-helix domains; Region: HTH; cl00088 768492006029 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492006030 dimerization interface [polypeptide binding]; other site 768492006031 Uncharacterized conserved protein [Function unknown]; Region: COG2850 768492006032 sensor protein PhoQ; Provisional; Region: PRK10815 768492006033 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 768492006034 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 768492006035 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492006036 ATP binding site [chemical binding]; other site 768492006037 Mg2+ binding site [ion binding]; other site 768492006038 G-X-G motif; other site 768492006039 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 768492006040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492006041 active site 768492006042 phosphorylation site [posttranslational modification] 768492006043 intermolecular recognition site; other site 768492006044 dimerization interface [polypeptide binding]; other site 768492006045 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768492006046 DNA binding site [nucleotide binding] 768492006047 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768492006048 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492006049 DNA-binding site [nucleotide binding]; DNA binding site 768492006050 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492006051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492006052 homodimer interface [polypeptide binding]; other site 768492006053 catalytic residue [active] 768492006054 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492006055 Coenzyme A binding pocket [chemical binding]; other site 768492006056 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 768492006057 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 768492006058 adenylosuccinate lyase; Provisional; Region: PRK09285 768492006059 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 768492006060 tetramer interface [polypeptide binding]; other site 768492006061 active site 768492006062 Protein of unknown function (DUF489); Region: DUF489; cl01097 768492006063 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 768492006064 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 768492006065 Ligand Binding Site [chemical binding]; other site 768492006066 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 768492006067 nudix motif; other site 768492006068 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 768492006069 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 768492006070 probable active site [active] 768492006071 isocitrate dehydrogenase; Validated; Region: PRK07362 768492006072 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 768492006073 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 768492006074 Autoinducer binding domain; Region: Autoind_bind; pfam03472 768492006075 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492006076 DNA binding residues [nucleotide binding] 768492006077 dimerization interface [polypeptide binding]; other site 768492006078 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 768492006079 Gram-negative bacterial tonB protein; Region: TonB; cl10048 768492006080 Domain of unknown function DUF20; Region: UPF0118; pfam01594 768492006081 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 768492006082 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492006083 Coenzyme A binding pocket [chemical binding]; other site 768492006084 putative acetyltransferase; Provisional; Region: PRK03624 768492006085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492006086 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768492006087 putative substrate translocation pore; other site 768492006088 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 768492006089 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492006090 DNA binding site [nucleotide binding] 768492006091 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 768492006092 putative ligand binding site [chemical binding]; other site 768492006093 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 768492006094 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492006095 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 768492006096 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 768492006097 Protein of unknown function; Region: DUF3658; pfam12395 768492006098 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 768492006099 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 768492006100 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 768492006101 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 768492006102 LysE type translocator; Region: LysE; cl00565 768492006103 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 768492006104 DNA-binding site [nucleotide binding]; DNA binding site 768492006105 RNA-binding motif; other site 768492006106 short chain dehydrogenase; Provisional; Region: PRK06138 768492006107 classical (c) SDRs; Region: SDR_c; cd05233 768492006108 NAD(P) binding site [chemical binding]; other site 768492006109 active site 768492006110 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492006111 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 768492006112 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 768492006113 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 768492006114 NAD(P) binding site [chemical binding]; other site 768492006115 catalytic residues [active] 768492006116 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 768492006117 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492006118 non-specific DNA binding site [nucleotide binding]; other site 768492006119 salt bridge; other site 768492006120 sequence-specific DNA binding site [nucleotide binding]; other site 768492006121 Cupin domain; Region: Cupin_2; cl09118 768492006122 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 768492006123 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 768492006124 catalytic triad [active] 768492006125 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 768492006126 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 768492006127 Spore germination protein; Region: Spore_permease; cl15802 768492006128 amino acid transporter; Region: 2A0306; TIGR00909 768492006129 aromatic amino acid exporter; Provisional; Region: PRK11689 768492006130 EamA-like transporter family; Region: EamA; cl01037 768492006131 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 768492006132 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 768492006133 Chorismate mutase type II; Region: CM_2; cl00693 768492006134 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 768492006135 N-formylglutamate amidohydrolase; Region: FGase; cl01522 768492006136 imidazolonepropionase; Validated; Region: PRK09356 768492006137 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 768492006138 active site 768492006139 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 768492006140 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492006141 DNA-binding site [nucleotide binding]; DNA binding site 768492006142 UTRA domain; Region: UTRA; cl01230 768492006143 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 768492006144 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 768492006145 active site 768492006146 HutD; Region: HutD; cl01532 768492006147 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 768492006148 NMT1-like family; Region: NMT1_2; cl15260 768492006149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492006150 dimer interface [polypeptide binding]; other site 768492006151 conserved gate region; other site 768492006152 putative PBP binding loops; other site 768492006153 ABC-ATPase subunit interface; other site 768492006154 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 768492006155 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 768492006156 Walker A/P-loop; other site 768492006157 ATP binding site [chemical binding]; other site 768492006158 Q-loop/lid; other site 768492006159 ABC transporter signature motif; other site 768492006160 Walker B; other site 768492006161 D-loop; other site 768492006162 H-loop/switch region; other site 768492006163 histidinol-phosphate aminotransferase; Provisional; Region: PRK05166 768492006164 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492006165 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492006166 homodimer interface [polypeptide binding]; other site 768492006167 catalytic residue [active] 768492006168 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 768492006169 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 768492006170 phosphate binding site [ion binding]; other site 768492006171 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768492006172 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492006173 DNA binding site [nucleotide binding] 768492006174 domain linker motif; other site 768492006175 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 768492006176 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 768492006177 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 768492006178 substrate binding [chemical binding]; other site 768492006179 active site 768492006180 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 768492006181 galactoside permease; Reviewed; Region: lacY; PRK09528 768492006182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492006183 putative substrate translocation pore; other site 768492006184 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492006185 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 768492006186 NAD(P) binding site [chemical binding]; other site 768492006187 active site 768492006188 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 768492006189 histidinol dehydrogenase; Region: hisD; TIGR00069 768492006190 NAD binding site [chemical binding]; other site 768492006191 dimerization interface [polypeptide binding]; other site 768492006192 product binding site; other site 768492006193 substrate binding site [chemical binding]; other site 768492006194 zinc binding site [ion binding]; other site 768492006195 catalytic residues [active] 768492006196 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 768492006197 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 768492006198 Walker A/P-loop; other site 768492006199 ATP binding site [chemical binding]; other site 768492006200 Q-loop/lid; other site 768492006201 ABC transporter signature motif; other site 768492006202 Walker B; other site 768492006203 D-loop; other site 768492006204 H-loop/switch region; other site 768492006205 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 768492006206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492006207 dimer interface [polypeptide binding]; other site 768492006208 conserved gate region; other site 768492006209 putative PBP binding loops; other site 768492006210 ABC-ATPase subunit interface; other site 768492006211 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 768492006212 NMT1-like family; Region: NMT1_2; cl15260 768492006213 metabolite-proton symporter; Region: 2A0106; TIGR00883 768492006214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492006215 putative substrate translocation pore; other site 768492006216 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492006217 Helix-turn-helix domains; Region: HTH; cl00088 768492006218 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492006219 Helix-turn-helix domains; Region: HTH; cl00088 768492006220 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 768492006221 putative effector binding pocket; other site 768492006222 putative dimerization interface [polypeptide binding]; other site 768492006223 hypothetical protein; Provisional; Region: PRK08204 768492006224 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 768492006225 active site 768492006226 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 768492006227 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 768492006228 active site 768492006229 substrate-binding site [chemical binding]; other site 768492006230 metal-binding site [ion binding] 768492006231 ATP binding site [chemical binding]; other site 768492006232 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 768492006233 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 768492006234 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 768492006235 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 768492006236 Spore Coat Protein U domain; Region: SCPU; cl02253 768492006237 Spore Coat Protein U domain; Region: SCPU; cl02253 768492006238 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 768492006239 PapC N-terminal domain; Region: PapC_N; pfam13954 768492006240 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 768492006241 PapC C-terminal domain; Region: PapC_C; pfam13953 768492006242 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 768492006243 Spore Coat Protein U domain; Region: SCPU; cl02253 768492006244 Spore Coat Protein U domain; Region: SCPU; cl02253 768492006245 Spore Coat Protein U domain; Region: SCPU; cl02253 768492006246 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 768492006247 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492006248 S-adenosylmethionine binding site [chemical binding]; other site 768492006249 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; cl01283 768492006250 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 768492006251 mce related protein; Region: MCE; pfam02470 768492006252 mce related protein; Region: MCE; pfam02470 768492006253 mce related protein; Region: MCE; pfam02470 768492006254 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 768492006255 mce related protein; Region: MCE; pfam02470 768492006256 mce related protein; Region: MCE; pfam02470 768492006257 mce related protein; Region: MCE; pfam02470 768492006258 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 768492006259 Paraquat-inducible protein A; Region: PqiA; pfam04403 768492006260 Paraquat-inducible protein A; Region: PqiA; pfam04403 768492006261 GAF domain; Region: GAF; cl15785 768492006262 ProP expression regulator; Provisional; Region: PRK04950 768492006263 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270 768492006264 putative RNA binding sites [nucleotide binding]; other site 768492006265 carboxy-terminal protease; Provisional; Region: PRK11186 768492006266 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 768492006267 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 768492006268 protein binding site [polypeptide binding]; other site 768492006269 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 768492006270 Catalytic dyad [active] 768492006271 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 768492006272 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 768492006273 Peptidase family M48; Region: Peptidase_M48; cl12018 768492006274 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 768492006275 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492006276 putative substrate translocation pore; other site 768492006277 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 768492006278 Helix-turn-helix domains; Region: HTH; cl00088 768492006279 Bacterial transcriptional regulator; Region: IclR; pfam01614 768492006280 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 768492006281 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 768492006282 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 768492006283 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 768492006284 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 768492006285 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492006286 motif II; other site 768492006287 YniB-like protein; Region: YniB; pfam14002 768492006288 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 768492006289 Phosphotransferase enzyme family; Region: APH; pfam01636 768492006290 Predicted acetyltransferase [General function prediction only]; Region: COG3393 768492006291 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492006292 Coenzyme A binding pocket [chemical binding]; other site 768492006293 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768492006294 ABC-ATPase subunit interface; other site 768492006295 dimer interface [polypeptide binding]; other site 768492006296 putative PBP binding regions; other site 768492006297 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768492006298 ABC-ATPase subunit interface; other site 768492006299 dimer interface [polypeptide binding]; other site 768492006300 putative PBP binding regions; other site 768492006301 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 768492006302 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 768492006303 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 768492006304 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 768492006305 metal binding site [ion binding]; metal-binding site 768492006306 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 768492006307 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 768492006308 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 768492006309 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768492006310 catalytic residue [active] 768492006311 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 768492006312 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 768492006313 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492006314 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 768492006315 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768492006316 Cytochrome c [Energy production and conversion]; Region: COG3258 768492006317 Cytochrome c; Region: Cytochrom_C; cl11414 768492006318 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 768492006319 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 768492006320 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 768492006321 intersubunit interface [polypeptide binding]; other site 768492006322 MarC family integral membrane protein; Region: MarC; cl00919 768492006323 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 768492006324 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 768492006325 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 768492006326 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 768492006327 active site 768492006328 dimer interface [polypeptide binding]; other site 768492006329 motif 1; other site 768492006330 motif 2; other site 768492006331 motif 3; other site 768492006332 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 768492006333 anticodon binding site; other site 768492006334 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 768492006335 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 768492006336 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 768492006337 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 768492006338 ribosomal protein L20; Region: rpl20; CHL00068 768492006339 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 768492006340 23S rRNA binding site [nucleotide binding]; other site 768492006341 L21 binding site [polypeptide binding]; other site 768492006342 L13 binding site [polypeptide binding]; other site 768492006343 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 768492006344 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 768492006345 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 768492006346 dimer interface [polypeptide binding]; other site 768492006347 motif 1; other site 768492006348 active site 768492006349 motif 2; other site 768492006350 motif 3; other site 768492006351 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 768492006352 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 768492006353 putative tRNA-binding site [nucleotide binding]; other site 768492006354 B3/4 domain; Region: B3_4; cl11458 768492006355 tRNA synthetase B5 domain; Region: B5; cl08394 768492006356 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 768492006357 dimer interface [polypeptide binding]; other site 768492006358 motif 1; other site 768492006359 motif 3; other site 768492006360 motif 2; other site 768492006361 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 768492006362 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 768492006363 IHF dimer interface [polypeptide binding]; other site 768492006364 IHF - DNA interface [nucleotide binding]; other site 768492006365 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 768492006366 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768492006367 dimer interface [polypeptide binding]; other site 768492006368 putative PBP binding regions; other site 768492006369 ABC-ATPase subunit interface; other site 768492006370 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 768492006371 catalytic residues [active] 768492006372 dimer interface [polypeptide binding]; other site 768492006373 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 768492006374 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768492006375 Walker A/P-loop; other site 768492006376 ATP binding site [chemical binding]; other site 768492006377 Q-loop/lid; other site 768492006378 ABC transporter signature motif; other site 768492006379 Walker B; other site 768492006380 D-loop; other site 768492006381 H-loop/switch region; other site 768492006382 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 768492006383 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 768492006384 inhibitor-cofactor binding pocket; inhibition site 768492006385 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492006386 catalytic residue [active] 768492006387 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 768492006388 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 768492006389 Ligand binding site; other site 768492006390 Putative Catalytic site; other site 768492006391 DXD motif; other site 768492006392 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 768492006393 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 768492006394 active site 768492006395 substrate binding site [chemical binding]; other site 768492006396 cosubstrate binding site; other site 768492006397 catalytic site [active] 768492006398 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 768492006399 active site 768492006400 hexamer interface [polypeptide binding]; other site 768492006401 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 768492006402 NAD binding site [chemical binding]; other site 768492006403 substrate binding site [chemical binding]; other site 768492006404 active site 768492006405 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 768492006406 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 768492006407 putative active site [active] 768492006408 putative catalytic site [active] 768492006409 putative Zn binding site [ion binding]; other site 768492006410 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 768492006411 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 768492006412 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 768492006413 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 768492006414 NlpC/P60 family; Region: NLPC_P60; cl11438 768492006415 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 768492006416 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 768492006417 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 768492006418 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768492006419 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 768492006420 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 768492006421 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 768492006422 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768492006423 Walker A/P-loop; other site 768492006424 ATP binding site [chemical binding]; other site 768492006425 Q-loop/lid; other site 768492006426 ABC transporter signature motif; other site 768492006427 Walker B; other site 768492006428 D-loop; other site 768492006429 H-loop/switch region; other site 768492006430 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768492006431 ABC-ATPase subunit interface; other site 768492006432 dimer interface [polypeptide binding]; other site 768492006433 putative PBP binding regions; other site 768492006434 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 768492006435 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 768492006436 putative hemin binding site; other site 768492006437 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 768492006438 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 768492006439 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 768492006440 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 768492006441 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768492006442 N-terminal plug; other site 768492006443 ligand-binding site [chemical binding]; other site 768492006444 Hemin uptake protein hemP; Region: hemP; cl10043 768492006445 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 768492006446 catalytic residues [active] 768492006447 dimer interface [polypeptide binding]; other site 768492006448 NeuB family; Region: NeuB; cl00496 768492006449 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 768492006450 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 768492006451 phosphoenolpyruvate synthase; Validated; Region: PRK06464 768492006452 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 768492006453 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 768492006454 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 768492006455 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 768492006456 Domain of unknown function DUF20; Region: UPF0118; pfam01594 768492006457 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 768492006458 FAD binding domain; Region: FAD_binding_4; pfam01565 768492006459 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 768492006460 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 768492006461 CoenzymeA binding site [chemical binding]; other site 768492006462 subunit interaction site [polypeptide binding]; other site 768492006463 PHB binding site; other site 768492006464 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 768492006465 putative ABC transporter; Region: ycf24; CHL00085 768492006466 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 768492006467 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 768492006468 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 768492006469 Walker A/P-loop; other site 768492006470 ATP binding site [chemical binding]; other site 768492006471 Q-loop/lid; other site 768492006472 ABC transporter signature motif; other site 768492006473 Walker B; other site 768492006474 D-loop; other site 768492006475 H-loop/switch region; other site 768492006476 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 768492006477 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 768492006478 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 768492006479 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 768492006480 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492006481 catalytic residue [active] 768492006482 Fe-S metabolism associated domain; Region: SufE; cl00951 768492006483 L,D-transpeptidase; Provisional; Region: PRK10190 768492006484 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 768492006485 putative peptidoglycan binding site; other site 768492006486 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 768492006487 Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539 768492006488 pyruvate kinase; Provisional; Region: PRK09206 768492006489 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 768492006490 domain interfaces; other site 768492006491 active site 768492006492 Cupin domain; Region: Cupin_2; cl09118 768492006493 multidrug efflux protein; Reviewed; Region: PRK01766 768492006494 MatE; Region: MatE; cl10513 768492006495 MatE; Region: MatE; cl10513 768492006496 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 768492006497 Lumazine binding domain; Region: Lum_binding; pfam00677 768492006498 Lumazine binding domain; Region: Lum_binding; pfam00677 768492006499 Potato inhibitor I family; Region: potato_inhibit; cl15459 768492006500 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 768492006501 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 768492006502 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492006503 S-adenosylmethionine binding site [chemical binding]; other site 768492006504 putative transporter; Provisional; Region: PRK11043 768492006505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492006506 putative substrate translocation pore; other site 768492006507 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 768492006508 Helix-turn-helix domains; Region: HTH; cl00088 768492006509 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492006510 dimerization interface [polypeptide binding]; other site 768492006511 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 768492006512 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492006513 DNA binding site [nucleotide binding] 768492006514 domain linker motif; other site 768492006515 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 768492006516 dimerization interface [polypeptide binding]; other site 768492006517 ligand binding site [chemical binding]; other site 768492006518 NlpC/P60 family; Region: NLPC_P60; cl11438 768492006519 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 768492006520 putative GSH binding site [chemical binding]; other site 768492006521 catalytic residues [active] 768492006522 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 768492006523 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 768492006524 dimer interface [polypeptide binding]; other site 768492006525 catalytic site [active] 768492006526 putative active site [active] 768492006527 putative substrate binding site [chemical binding]; other site 768492006528 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768492006529 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 768492006530 dimer interface [polypeptide binding]; other site 768492006531 active site 768492006532 metal binding site [ion binding]; metal-binding site 768492006533 glutathione binding site [chemical binding]; other site 768492006534 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 768492006535 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 768492006536 active site 768492006537 metal binding site [ion binding]; metal-binding site 768492006538 nudix motif; other site 768492006539 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 768492006540 FMN binding site [chemical binding]; other site 768492006541 active site 768492006542 substrate binding site [chemical binding]; other site 768492006543 catalytic residue [active] 768492006544 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492006545 Helix-turn-helix domains; Region: HTH; cl00088 768492006546 putative metal dependent hydrolase; Provisional; Region: PRK11598 768492006547 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 768492006548 Sulfatase; Region: Sulfatase; cl10460 768492006549 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 768492006550 NADH(P)-binding; Region: NAD_binding_10; pfam13460 768492006551 NAD binding site [chemical binding]; other site 768492006552 substrate binding site [chemical binding]; other site 768492006553 putative active site [active] 768492006554 transcriptional regulator; Provisional; Region: PRK10632 768492006555 Helix-turn-helix domains; Region: HTH; cl00088 768492006556 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492006557 putative effector binding pocket; other site 768492006558 dimerization interface [polypeptide binding]; other site 768492006559 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 768492006560 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768492006561 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768492006562 active site 768492006563 catalytic tetrad [active] 768492006564 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 768492006565 nucleophilic elbow; other site 768492006566 catalytic triad; other site 768492006567 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 768492006568 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 768492006569 E-class dimer interface [polypeptide binding]; other site 768492006570 P-class dimer interface [polypeptide binding]; other site 768492006571 active site 768492006572 Cu2+ binding site [ion binding]; other site 768492006573 Zn2+ binding site [ion binding]; other site 768492006574 Fusaric acid resistance protein family; Region: FUSC; pfam04632 768492006575 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 768492006576 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 768492006577 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 768492006578 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 768492006579 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 768492006580 transcriptional regulator SlyA; Provisional; Region: PRK03573 768492006581 Helix-turn-helix domains; Region: HTH; cl00088 768492006582 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 768492006583 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 768492006584 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604 768492006585 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 768492006586 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 768492006587 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 768492006588 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 768492006589 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 768492006590 active site 768492006591 HIGH motif; other site 768492006592 dimer interface [polypeptide binding]; other site 768492006593 KMSKS motif; other site 768492006594 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768492006595 RNA binding surface [nucleotide binding]; other site 768492006596 pyridoxamine kinase; Validated; Region: PRK05756 768492006597 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 768492006598 dimer interface [polypeptide binding]; other site 768492006599 pyridoxal binding site [chemical binding]; other site 768492006600 ATP binding site [chemical binding]; other site 768492006601 glutathionine S-transferase; Provisional; Region: PRK10542 768492006602 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 768492006603 C-terminal domain interface [polypeptide binding]; other site 768492006604 GSH binding site (G-site) [chemical binding]; other site 768492006605 dimer interface [polypeptide binding]; other site 768492006606 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 768492006607 dimer interface [polypeptide binding]; other site 768492006608 N-terminal domain interface [polypeptide binding]; other site 768492006609 substrate binding pocket (H-site) [chemical binding]; other site 768492006610 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 768492006611 dihydrodipicolinate synthase; Region: dapA; TIGR00674 768492006612 dimer interface [polypeptide binding]; other site 768492006613 active site 768492006614 catalytic residue [active] 768492006615 YjbD family (DUF3811); Region: DUF3811; cl08125 768492006616 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 768492006617 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 768492006618 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 768492006619 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 768492006620 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 768492006621 homotrimer interaction site [polypeptide binding]; other site 768492006622 putative active site [active] 768492006623 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 768492006624 Cupin domain; Region: Cupin_2; cl09118 768492006625 MEKHLA domain; Region: MEKHLA; pfam08670 768492006626 benzoate transporter; Region: benE; TIGR00843 768492006627 Benzoate membrane transport protein; Region: BenE; pfam03594 768492006628 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 768492006629 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492006630 non-specific DNA binding site [nucleotide binding]; other site 768492006631 salt bridge; other site 768492006632 sequence-specific DNA binding site [nucleotide binding]; other site 768492006633 Cupin domain; Region: Cupin_2; cl09118 768492006634 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 768492006635 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 768492006636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 768492006637 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 768492006638 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 768492006639 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 768492006640 putative symporter YagG; Provisional; Region: PRK09669 768492006641 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768492006642 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492006643 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492006644 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768492006645 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492006646 putative symporter YagG; Provisional; Region: PRK09669 768492006647 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 768492006648 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 768492006649 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 768492006650 inhibitor binding site; inhibition site 768492006651 active site 768492006652 endonuclease III; Provisional; Region: PRK10702 768492006653 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 768492006654 minor groove reading motif; other site 768492006655 helix-hairpin-helix signature motif; other site 768492006656 substrate binding pocket [chemical binding]; other site 768492006657 active site 768492006658 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 768492006659 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 768492006660 FMN-binding domain; Region: FMN_bind; cl01081 768492006661 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 768492006662 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 768492006663 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492006664 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 768492006665 electron transport complex protein RnfC; Provisional; Region: PRK05035 768492006666 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 768492006667 SLBB domain; Region: SLBB; pfam10531 768492006668 4Fe-4S binding domain; Region: Fer4; cl02805 768492006669 electron transport complex protein RnfB; Provisional; Region: PRK05113 768492006670 Putative Fe-S cluster; Region: FeS; pfam04060 768492006671 4Fe-4S binding domain; Region: Fer4; cl02805 768492006672 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 768492006673 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 768492006674 L-arabinose isomerase; Provisional; Region: PRK02929 768492006675 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 768492006676 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 768492006677 trimer interface [polypeptide binding]; other site 768492006678 putative substrate binding site [chemical binding]; other site 768492006679 putative metal binding site [ion binding]; other site 768492006680 ribulokinase; Provisional; Region: PRK04123 768492006681 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 768492006682 putative N- and C-terminal domain interface [polypeptide binding]; other site 768492006683 putative active site [active] 768492006684 putative MgATP binding site [chemical binding]; other site 768492006685 catalytic site [active] 768492006686 metal binding site [ion binding]; metal-binding site 768492006687 carbohydrate binding site [chemical binding]; other site 768492006688 homodimer interface [polypeptide binding]; other site 768492006689 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 768492006690 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 768492006691 ligand binding site [chemical binding]; other site 768492006692 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 768492006693 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 768492006694 Walker A/P-loop; other site 768492006695 ATP binding site [chemical binding]; other site 768492006696 Q-loop/lid; other site 768492006697 ABC transporter signature motif; other site 768492006698 Walker B; other site 768492006699 D-loop; other site 768492006700 H-loop/switch region; other site 768492006701 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 768492006702 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768492006703 TM-ABC transporter signature motif; other site 768492006704 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 768492006705 Cupin domain; Region: Cupin_2; cl09118 768492006706 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492006707 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492006708 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 768492006709 substrate binding pocket [chemical binding]; other site 768492006710 substrate-Mg2+ binding site; other site 768492006711 aspartate-rich region 1; other site 768492006712 aspartate-rich region 2; other site 768492006713 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492006714 S-adenosylmethionine binding site [chemical binding]; other site 768492006715 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 768492006716 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 768492006717 TPP-binding site; other site 768492006718 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 768492006719 PYR/PP interface [polypeptide binding]; other site 768492006720 dimer interface [polypeptide binding]; other site 768492006721 TPP binding site [chemical binding]; other site 768492006722 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768492006723 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 768492006724 active site 768492006725 metal binding site [ion binding]; metal-binding site 768492006726 nudix motif; other site 768492006727 putative oxidoreductase; Provisional; Region: PRK11579 768492006728 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492006729 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 768492006730 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 768492006731 Membrane transport protein; Region: Mem_trans; cl09117 768492006732 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 768492006733 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 768492006734 active site 768492006735 purine riboside binding site [chemical binding]; other site 768492006736 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492006737 AAA domain; Region: AAA_18; pfam13238 768492006738 active site 768492006739 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 768492006740 active site 768492006741 phosphorylation site [posttranslational modification] 768492006742 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 768492006743 hypothetical protein; Provisional; Region: PRK08185 768492006744 intersubunit interface [polypeptide binding]; other site 768492006745 active site 768492006746 zinc binding site [ion binding]; other site 768492006747 Na+ binding site [ion binding]; other site 768492006748 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 768492006749 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 768492006750 active site 768492006751 P-loop; other site 768492006752 phosphorylation site [posttranslational modification] 768492006753 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 768492006754 active site 768492006755 ADP/pyrophosphate binding site [chemical binding]; other site 768492006756 dimerization interface [polypeptide binding]; other site 768492006757 allosteric effector site; other site 768492006758 fructose-1,6-bisphosphate binding site; other site 768492006759 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 768492006760 Helix-turn-helix domains; Region: HTH; cl00088 768492006761 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 768492006762 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 768492006763 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 768492006764 dimer interface [polypeptide binding]; other site 768492006765 ADP-ribose binding site [chemical binding]; other site 768492006766 active site 768492006767 nudix motif; other site 768492006768 metal binding site [ion binding]; metal-binding site 768492006769 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl16920 768492006770 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 768492006771 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492006772 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492006773 homodimer interface [polypeptide binding]; other site 768492006774 catalytic residue [active] 768492006775 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 768492006776 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 768492006777 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768492006778 active site turn [active] 768492006779 phosphorylation site [posttranslational modification] 768492006780 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 768492006781 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492006782 DNA binding site [nucleotide binding] 768492006783 domain linker motif; other site 768492006784 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 768492006785 putative dimerization interface [polypeptide binding]; other site 768492006786 putative ligand binding site [chemical binding]; other site 768492006787 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768492006788 Helix-turn-helix domains; Region: HTH; cl00088 768492006789 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492006790 dimerization interface [polypeptide binding]; other site 768492006791 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 768492006792 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492006793 Helix-turn-helix domains; Region: HTH; cl00088 768492006794 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 768492006795 putative effector binding pocket; other site 768492006796 putative dimerization interface [polypeptide binding]; other site 768492006797 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 768492006798 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 768492006799 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339; cl15420 768492006800 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 768492006801 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 768492006802 fumarate hydratase; Reviewed; Region: fumC; PRK00485 768492006803 Class II fumarases; Region: Fumarase_classII; cd01362 768492006804 active site 768492006805 tetramer interface [polypeptide binding]; other site 768492006806 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 768492006807 putative catalytic residues [active] 768492006808 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492006809 Helix-turn-helix domains; Region: HTH; cl00088 768492006810 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492006811 putative effector binding pocket; other site 768492006812 dimerization interface [polypeptide binding]; other site 768492006813 Helix-turn-helix domains; Region: HTH; cl00088 768492006814 WYL domain; Region: WYL; cl14852 768492006815 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768492006816 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 768492006817 putative dimer interface [polypeptide binding]; other site 768492006818 DNA replication terminus site-binding protein (Ter protein); Region: Ter; cl11502 768492006819 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768492006820 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492006821 putative substrate translocation pore; other site 768492006822 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 768492006823 Helix-turn-helix domains; Region: HTH; cl00088 768492006824 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 768492006825 dimerization interface [polypeptide binding]; other site 768492006826 substrate binding pocket [chemical binding]; other site 768492006827 Helix-turn-helix domains; Region: HTH; cl00088 768492006828 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 768492006829 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 768492006830 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492006831 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 768492006832 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 768492006833 Cl- selectivity filter; other site 768492006834 Cl- binding residues [ion binding]; other site 768492006835 pore gating glutamate residue; other site 768492006836 dimer interface [polypeptide binding]; other site 768492006837 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492006838 putative substrate translocation pore; other site 768492006839 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 768492006840 Protein of unknown function (DUF1283); Region: DUF1283; cl11644 768492006841 Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 768492006842 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 768492006843 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 768492006844 putative NAD(P) binding site [chemical binding]; other site 768492006845 homodimer interface [polypeptide binding]; other site 768492006846 homotetramer interface [polypeptide binding]; other site 768492006847 active site 768492006848 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768492006849 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 768492006850 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 768492006851 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768492006852 active site 768492006853 catalytic tetrad [active] 768492006854 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492006855 putative transporter; Provisional; Region: PRK10504 768492006856 putative substrate translocation pore; other site 768492006857 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 768492006858 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492006859 Walker A/P-loop; other site 768492006860 ATP binding site [chemical binding]; other site 768492006861 Q-loop/lid; other site 768492006862 ABC transporter signature motif; other site 768492006863 Walker B; other site 768492006864 D-loop; other site 768492006865 H-loop/switch region; other site 768492006866 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 768492006867 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768492006868 substrate binding site [chemical binding]; other site 768492006869 ATP binding site [chemical binding]; other site 768492006870 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 768492006871 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492006872 dimer interface [polypeptide binding]; other site 768492006873 conserved gate region; other site 768492006874 putative PBP binding loops; other site 768492006875 ABC-ATPase subunit interface; other site 768492006876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492006877 dimer interface [polypeptide binding]; other site 768492006878 conserved gate region; other site 768492006879 putative PBP binding loops; other site 768492006880 ABC-ATPase subunit interface; other site 768492006881 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 768492006882 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492006883 Helix-turn-helix domains; Region: HTH; cl00088 768492006884 non-specific DNA interactions [nucleotide binding]; other site 768492006885 DNA binding site [nucleotide binding] 768492006886 sequence specific DNA binding site [nucleotide binding]; other site 768492006887 putative cAMP binding site [chemical binding]; other site 768492006888 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 768492006889 Chitin binding domain; Region: Chitin_bind_3; cl03871 768492006890 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 768492006891 Interdomain contacts; other site 768492006892 Cytokine receptor motif; other site 768492006893 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 768492006894 Interdomain contacts; other site 768492006895 Cytokine receptor motif; other site 768492006896 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 768492006897 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 768492006898 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 768492006899 putative active site [active] 768492006900 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 768492006901 Interdomain contacts; other site 768492006902 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 768492006903 guanine deaminase; Provisional; Region: PRK09228 768492006904 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 768492006905 active site 768492006906 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 768492006907 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 768492006908 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 768492006909 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 768492006910 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 768492006911 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 768492006912 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768492006913 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 768492006914 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 768492006915 XdhC Rossmann domain; Region: XdhC_C; pfam13478 768492006916 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 768492006917 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 768492006918 NAD binding site [chemical binding]; other site 768492006919 sugar binding site [chemical binding]; other site 768492006920 divalent metal binding site [ion binding]; other site 768492006921 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 768492006922 dimer interface [polypeptide binding]; other site 768492006923 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 768492006924 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 768492006925 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768492006926 active site turn [active] 768492006927 phosphorylation site [posttranslational modification] 768492006928 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 768492006929 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492006930 DNA-binding site [nucleotide binding]; DNA binding site 768492006931 UTRA domain; Region: UTRA; cl01230 768492006932 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 768492006933 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 768492006934 Ca binding site [ion binding]; other site 768492006935 active site 768492006936 catalytic site [active] 768492006937 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 768492006938 Cytochrome c; Region: Cytochrom_C; cl11414 768492006939 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 768492006940 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 768492006941 active site 768492006942 Zn binding site [ion binding]; other site 768492006943 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 768492006944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492006945 putative substrate translocation pore; other site 768492006946 Isochorismatase family; Region: Isochorismatase; pfam00857 768492006947 N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015 768492006948 catalytic triad [active] 768492006949 substrate binding site [chemical binding]; other site 768492006950 domain interfaces; other site 768492006951 conserved cis-peptide bond; other site 768492006952 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 768492006953 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768492006954 hypothetical protein; Provisional; Region: PRK06847 768492006955 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492006956 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 768492006957 Transcriptional regulators [Transcription]; Region: MarR; COG1846 768492006958 Helix-turn-helix domains; Region: HTH; cl00088 768492006959 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 768492006960 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 768492006961 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 768492006962 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768492006963 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 768492006964 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 768492006965 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768492006966 Cytochrome c; Region: Cytochrom_C; cl11414 768492006967 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768492006968 Cytochrome c; Region: Cytochrom_C; cl11414 768492006969 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 768492006970 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 768492006971 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 768492006972 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 768492006973 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39C; cd02419 768492006974 putative active site [active] 768492006975 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 768492006976 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492006977 Walker A/P-loop; other site 768492006978 ATP binding site [chemical binding]; other site 768492006979 Q-loop/lid; other site 768492006980 ABC transporter signature motif; other site 768492006981 Walker B; other site 768492006982 D-loop; other site 768492006983 H-loop/switch region; other site 768492006984 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492006985 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 768492006986 homodimer interface [polypeptide binding]; other site 768492006987 homotetramer interface [polypeptide binding]; other site 768492006988 active site pocket [active] 768492006989 cleavage site 768492006990 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 768492006991 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 768492006992 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768492006993 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 768492006994 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768492006995 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768492006996 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 768492006997 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 768492006998 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 768492006999 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768492007000 Cytochrome c; Region: Cytochrom_C; cl11414 768492007001 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 768492007002 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768492007003 active site turn [active] 768492007004 phosphorylation site [posttranslational modification] 768492007005 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 768492007006 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 768492007007 HPr interaction site; other site 768492007008 glycerol kinase (GK) interaction site [polypeptide binding]; other site 768492007009 active site 768492007010 phosphorylation site [posttranslational modification] 768492007011 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 768492007012 transcriptional antiterminator BglG; Provisional; Region: PRK09772 768492007013 CAT RNA binding domain; Region: CAT_RBD; cl03904 768492007014 PRD domain; Region: PRD; cl15445 768492007015 PRD domain; Region: PRD; cl15445 768492007016 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 768492007017 Helix-turn-helix domains; Region: HTH; cl00088 768492007018 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 768492007019 putative dimerization interface [polypeptide binding]; other site 768492007020 putative substrate binding pocket [chemical binding]; other site 768492007021 Chromate transporter; Region: Chromate_transp; pfam02417 768492007022 Chromate transporter; Region: Chromate_transp; pfam02417 768492007023 Protease inhibitor Inh; Region: Inh; pfam02974 768492007024 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 768492007025 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 768492007026 classical (c) SDRs; Region: SDR_c; cd05233 768492007027 flagellin modification protein A; Provisional; Region: PRK09186 768492007028 NAD(P) binding site [chemical binding]; other site 768492007029 active site 768492007030 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492007031 DNA binding site [nucleotide binding] 768492007032 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 768492007033 putative ligand binding site [chemical binding]; other site 768492007034 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 768492007035 putative active site [active] 768492007036 EamA-like transporter family; Region: EamA; cl01037 768492007037 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768492007038 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492007039 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 768492007040 active site 768492007041 metal binding site [ion binding]; metal-binding site 768492007042 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 768492007043 NIPSNAP; Region: NIPSNAP; pfam07978 768492007044 drug efflux system protein MdtG; Provisional; Region: PRK09874 768492007045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007046 putative substrate translocation pore; other site 768492007047 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 768492007048 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 768492007049 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492007050 active site 768492007051 motif I; other site 768492007052 motif II; other site 768492007053 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 768492007054 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 768492007055 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 768492007056 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768492007057 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 768492007058 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 768492007059 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 768492007060 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 768492007061 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 768492007062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492007063 dimer interface [polypeptide binding]; other site 768492007064 conserved gate region; other site 768492007065 putative PBP binding loops; other site 768492007066 ABC-ATPase subunit interface; other site 768492007067 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 768492007068 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 768492007069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492007070 dimer interface [polypeptide binding]; other site 768492007071 conserved gate region; other site 768492007072 putative PBP binding loops; other site 768492007073 ABC-ATPase subunit interface; other site 768492007074 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 768492007075 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 768492007076 Walker A/P-loop; other site 768492007077 ATP binding site [chemical binding]; other site 768492007078 Q-loop/lid; other site 768492007079 ABC transporter signature motif; other site 768492007080 Walker B; other site 768492007081 D-loop; other site 768492007082 H-loop/switch region; other site 768492007083 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768492007084 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 768492007085 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 768492007086 Walker A/P-loop; other site 768492007087 ATP binding site [chemical binding]; other site 768492007088 Q-loop/lid; other site 768492007089 ABC transporter signature motif; other site 768492007090 Walker B; other site 768492007091 D-loop; other site 768492007092 H-loop/switch region; other site 768492007093 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768492007094 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 768492007095 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 768492007096 active site 768492007097 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 768492007098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007099 putative substrate translocation pore; other site 768492007100 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492007101 Helix-turn-helix domains; Region: HTH; cl00088 768492007102 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492007103 dimerization interface [polypeptide binding]; other site 768492007104 penicillin-binding protein 2; Provisional; Region: PRK10795 768492007105 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 768492007106 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 768492007107 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 768492007108 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 768492007109 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 768492007110 lipoprotein; Provisional; Region: PRK10540 768492007111 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768492007112 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492007113 Coenzyme A binding pocket [chemical binding]; other site 768492007114 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 768492007115 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 768492007116 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 768492007117 Walker A/P-loop; other site 768492007118 ATP binding site [chemical binding]; other site 768492007119 Q-loop/lid; other site 768492007120 ABC transporter signature motif; other site 768492007121 Walker B; other site 768492007122 D-loop; other site 768492007123 H-loop/switch region; other site 768492007124 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768492007125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492007126 dimer interface [polypeptide binding]; other site 768492007127 conserved gate region; other site 768492007128 putative PBP binding loops; other site 768492007129 ABC-ATPase subunit interface; other site 768492007130 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492007131 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768492007132 substrate binding pocket [chemical binding]; other site 768492007133 membrane-bound complex binding site; other site 768492007134 hinge residues; other site 768492007135 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 768492007136 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 768492007137 active site 768492007138 non-prolyl cis peptide bond; other site 768492007139 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 768492007140 LysR family transcriptional regulator; Provisional; Region: PRK14997 768492007141 Helix-turn-helix domains; Region: HTH; cl00088 768492007142 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 768492007143 putative effector binding pocket; other site 768492007144 putative dimerization interface [polypeptide binding]; other site 768492007145 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 768492007146 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768492007147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007148 putative substrate translocation pore; other site 768492007149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007151 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 768492007152 folate binding site [chemical binding]; other site 768492007153 NADP+ binding site [chemical binding]; other site 768492007154 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 768492007155 Uncharacterized conserved protein [Function unknown]; Region: COG5276 768492007156 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 768492007157 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 768492007158 putative ligand binding site [chemical binding]; other site 768492007159 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 768492007160 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 768492007161 putative active site [active] 768492007162 metal binding site [ion binding]; metal-binding site 768492007163 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 768492007164 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 768492007165 putative NADP binding site [chemical binding]; other site 768492007166 putative substrate binding site [chemical binding]; other site 768492007167 active site 768492007168 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492007169 Helix-turn-helix domains; Region: HTH; cl00088 768492007170 Cupin domain; Region: Cupin_2; cl09118 768492007171 Pirin-related protein [General function prediction only]; Region: COG1741 768492007172 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 768492007173 Helix-turn-helix domains; Region: HTH; cl00088 768492007174 NmrA-like family; Region: NmrA; pfam05368 768492007175 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 768492007176 NADP binding site [chemical binding]; other site 768492007177 active site 768492007178 regulatory binding site [polypeptide binding]; other site 768492007179 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 768492007180 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 768492007181 putative NAD(P) binding site [chemical binding]; other site 768492007182 LysR family transcriptional regulator; Provisional; Region: PRK14997 768492007183 Helix-turn-helix domains; Region: HTH; cl00088 768492007184 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492007185 putative effector binding pocket; other site 768492007186 dimerization interface [polypeptide binding]; other site 768492007187 Protein of unknown function (DUF419); Region: DUF419; cl15265 768492007188 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 768492007189 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 768492007190 Walker A/P-loop; other site 768492007191 ATP binding site [chemical binding]; other site 768492007192 Q-loop/lid; other site 768492007193 ABC transporter signature motif; other site 768492007194 Walker B; other site 768492007195 D-loop; other site 768492007196 H-loop/switch region; other site 768492007197 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 768492007198 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492007199 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 768492007200 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492007201 dimer interface [polypeptide binding]; other site 768492007202 conserved gate region; other site 768492007203 ABC-ATPase subunit interface; other site 768492007204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492007205 dimer interface [polypeptide binding]; other site 768492007206 conserved gate region; other site 768492007207 putative PBP binding loops; other site 768492007208 ABC-ATPase subunit interface; other site 768492007209 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 768492007210 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 768492007211 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 768492007212 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 768492007213 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 768492007214 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768492007215 active site turn [active] 768492007216 phosphorylation site [posttranslational modification] 768492007217 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 768492007218 trimer interface; other site 768492007219 sugar binding site [chemical binding]; other site 768492007220 lac repressor; Reviewed; Region: lacI; PRK09526 768492007221 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492007222 DNA binding site [nucleotide binding] 768492007223 domain linker motif; other site 768492007224 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 768492007225 ligand binding site [chemical binding]; other site 768492007226 dimerization interface (open form) [polypeptide binding]; other site 768492007227 dimerization interface (closed form) [polypeptide binding]; other site 768492007228 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492007229 Helix-turn-helix domains; Region: HTH; cl00088 768492007230 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768492007231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007232 putative substrate translocation pore; other site 768492007233 Alcaligenes xylosoxidans NreA and related domains; this domain family was previously known as part of DUF156; Region: NreA-like_DUF156; cd10154 768492007234 putative homodimer interface [polypeptide binding]; other site 768492007235 putative homotetramer interface [polypeptide binding]; other site 768492007236 putative metal binding site [ion binding]; other site 768492007237 putative homodimer-homodimer interface [polypeptide binding]; other site 768492007238 putative allosteric switch controlling residues; other site 768492007239 High-affinity nickel-transport protein; Region: NicO; cl00964 768492007240 High-affinity nickel-transport protein; Region: NicO; cl00964 768492007241 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 768492007242 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 768492007243 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 768492007244 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 768492007245 Rdx family; Region: Rdx; cl01407 768492007246 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 768492007247 Bacterial transcriptional regulator; Region: IclR; pfam01614 768492007248 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 768492007249 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492007250 Walker A motif; other site 768492007251 ATP binding site [chemical binding]; other site 768492007252 Walker B motif; other site 768492007253 arginine finger; other site 768492007254 Helix-turn-helix domains; Region: HTH; cl00088 768492007255 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768492007256 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492007257 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 768492007258 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 768492007259 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 768492007260 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 768492007261 putative ligand binding site [chemical binding]; other site 768492007262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007263 transcriptional regulator, ArgP family; Region: argP; TIGR03298 768492007264 Helix-turn-helix domains; Region: HTH; cl00088 768492007265 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492007266 putative effector binding pocket; other site 768492007267 dimerization interface [polypeptide binding]; other site 768492007268 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 768492007269 Amidinotransferase; Region: Amidinotransf; cl12043 768492007270 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 768492007271 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492007272 substrate binding pocket [chemical binding]; other site 768492007273 membrane-bound complex binding site; other site 768492007274 hinge residues; other site 768492007275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492007276 dimer interface [polypeptide binding]; other site 768492007277 conserved gate region; other site 768492007278 putative PBP binding loops; other site 768492007279 ABC-ATPase subunit interface; other site 768492007280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492007281 dimer interface [polypeptide binding]; other site 768492007282 conserved gate region; other site 768492007283 putative PBP binding loops; other site 768492007284 ABC-ATPase subunit interface; other site 768492007285 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768492007286 Helix-turn-helix domains; Region: HTH; cl00088 768492007287 AsnC family; Region: AsnC_trans_reg; pfam01037 768492007288 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 768492007289 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 768492007290 active site 768492007291 Zn binding site [ion binding]; other site 768492007292 Fic family protein [Function unknown]; Region: COG3177 768492007293 Fic/DOC family; Region: Fic; cl00960 768492007294 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 768492007295 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 768492007296 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492007297 Walker A/P-loop; other site 768492007298 ATP binding site [chemical binding]; other site 768492007299 Q-loop/lid; other site 768492007300 ABC transporter signature motif; other site 768492007301 Walker B; other site 768492007302 D-loop; other site 768492007303 H-loop/switch region; other site 768492007304 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 768492007305 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 768492007306 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 768492007307 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 768492007308 NAD binding site [chemical binding]; other site 768492007309 substrate binding site [chemical binding]; other site 768492007310 catalytic Zn binding site [ion binding]; other site 768492007311 tetramer interface [polypeptide binding]; other site 768492007312 structural Zn binding site [ion binding]; other site 768492007313 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Region: ALDH_ACDHII_AcoD-like; cd07559 768492007314 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 768492007315 NAD(P) binding site [chemical binding]; other site 768492007316 catalytic residues [active] 768492007317 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 768492007318 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492007319 Walker A motif; other site 768492007320 ATP binding site [chemical binding]; other site 768492007321 Walker B motif; other site 768492007322 arginine finger; other site 768492007323 Helix-turn-helix domains; Region: HTH; cl00088 768492007324 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492007325 Helix-turn-helix domains; Region: HTH; cl00088 768492007326 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 768492007327 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 768492007328 NAD(P) binding site [chemical binding]; other site 768492007329 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768492007330 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492007331 substrate binding pocket [chemical binding]; other site 768492007332 membrane-bound complex binding site; other site 768492007333 hinge residues; other site 768492007334 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492007335 Helix-turn-helix domains; Region: HTH; cl00088 768492007336 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492007337 putative effector binding pocket; other site 768492007338 dimerization interface [polypeptide binding]; other site 768492007339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007340 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768492007341 putative substrate translocation pore; other site 768492007342 PAS fold; Region: PAS_4; pfam08448 768492007343 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768492007344 putative active site [active] 768492007345 heme pocket [chemical binding]; other site 768492007346 PAS fold; Region: PAS_4; pfam08448 768492007347 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768492007348 putative active site [active] 768492007349 heme pocket [chemical binding]; other site 768492007350 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768492007351 metal binding site [ion binding]; metal-binding site 768492007352 active site 768492007353 I-site; other site 768492007354 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768492007355 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 768492007356 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 768492007357 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 768492007358 Trp docking motif [polypeptide binding]; other site 768492007359 putative active site [active] 768492007360 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 768492007361 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 768492007362 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 768492007363 putative substrate binding pocket [chemical binding]; other site 768492007364 putative dimerization interface [polypeptide binding]; other site 768492007365 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 768492007366 NADP binding site [chemical binding]; other site 768492007367 homodimer interface [polypeptide binding]; other site 768492007368 active site 768492007369 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 768492007370 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 768492007371 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492007372 catalytic residue [active] 768492007373 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 768492007374 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768492007375 inhibitor-cofactor binding pocket; inhibition site 768492007376 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492007377 catalytic residue [active] 768492007378 Fucose-binding lectin II (PA-IIL); Region: PA-IIL; pfam07472 768492007379 RHS Repeat; Region: RHS_repeat; cl11982 768492007380 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 768492007381 RHS Repeat; Region: RHS_repeat; cl11982 768492007382 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 768492007383 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 768492007384 MltA-interacting protein MipA; Region: MipA; cl01504 768492007385 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 768492007386 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 768492007387 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 768492007388 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 768492007389 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 768492007390 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 768492007391 Surface antigen; Region: Bac_surface_Ag; cl03097 768492007392 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 768492007393 active site 768492007394 catalytic residues [active] 768492007395 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768492007396 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492007397 DNA binding site [nucleotide binding] 768492007398 domain linker motif; other site 768492007399 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 768492007400 ligand binding site [chemical binding]; other site 768492007401 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 768492007402 active site 768492007403 P-loop; other site 768492007404 phosphorylation site [posttranslational modification] 768492007405 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 768492007406 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 768492007407 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 768492007408 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 768492007409 methionine cluster; other site 768492007410 active site 768492007411 phosphorylation site [posttranslational modification] 768492007412 metal binding site [ion binding]; metal-binding site 768492007413 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 768492007414 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492007415 Helix-turn-helix domains; Region: HTH; cl00088 768492007416 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 768492007417 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 768492007418 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 768492007419 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768492007420 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 768492007421 E3 interaction surface; other site 768492007422 lipoyl attachment site [posttranslational modification]; other site 768492007423 e3 binding domain; Region: E3_binding; pfam02817 768492007424 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 768492007425 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 768492007426 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 768492007427 dimer interface [polypeptide binding]; other site 768492007428 TPP-binding site [chemical binding]; other site 768492007429 Helix-turn-helix domains; Region: HTH; cl00088 768492007430 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768492007431 FAD dependent oxidoreductase; Region: DAO; pfam01266 768492007432 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492007433 Helix-turn-helix domains; Region: HTH; cl00088 768492007434 short chain dehydrogenase; Provisional; Region: PRK06179 768492007435 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 768492007436 NADP binding site [chemical binding]; other site 768492007437 active site 768492007438 steroid binding site; other site 768492007439 YCII-related domain; Region: YCII; cl00999 768492007440 Helix-turn-helix domains; Region: HTH; cl00088 768492007441 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 768492007442 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 768492007443 NADP binding site [chemical binding]; other site 768492007444 Helix-turn-helix domains; Region: HTH; cl00088 768492007445 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768492007446 EamA-like transporter family; Region: EamA; cl01037 768492007447 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 768492007448 EamA-like transporter family; Region: EamA; cl01037 768492007449 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 768492007450 dimer interface [polypeptide binding]; other site 768492007451 FMN binding site [chemical binding]; other site 768492007452 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 768492007453 Winged helix-turn helix; Region: HTH_29; pfam13551 768492007454 Helix-turn-helix domains; Region: HTH; cl00088 768492007455 Helix-turn-helix domains; Region: HTH; cl00088 768492007456 Integrase core domain; Region: rve; cl01316 768492007457 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768492007458 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 768492007459 Helix-turn-helix domains; Region: HTH; cl00088 768492007460 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 768492007461 dimerization interface [polypeptide binding]; other site 768492007462 substrate binding pocket [chemical binding]; other site 768492007463 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 768492007464 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 768492007465 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 768492007466 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 768492007467 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492007468 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492007469 Helix-turn-helix domains; Region: HTH; cl00088 768492007470 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 768492007471 putative substrate binding pocket [chemical binding]; other site 768492007472 putative dimerization interface [polypeptide binding]; other site 768492007473 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 768492007474 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 768492007475 Helix-turn-helix domains; Region: HTH; cl00088 768492007476 Helix-turn-helix domains; Region: HTH; cl00088 768492007477 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492007478 Coenzyme A binding pocket [chemical binding]; other site 768492007479 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 768492007480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007481 putative substrate translocation pore; other site 768492007482 Cyclophilin-like; Region: Cyclophil_like; cl00950 768492007483 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 768492007484 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 768492007485 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492007486 Helix-turn-helix domains; Region: HTH; cl00088 768492007487 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 768492007488 putative effector binding pocket; other site 768492007489 putative dimerization interface [polypeptide binding]; other site 768492007490 Helix-turn-helix domains; Region: HTH; cl00088 768492007491 transcriptional activator TtdR; Provisional; Region: PRK09801 768492007492 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492007493 dimerization interface [polypeptide binding]; other site 768492007494 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 768492007495 active site 768492007496 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 768492007497 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 768492007498 YheO-like PAS domain; Region: PAS_6; pfam08348 768492007499 Helix-turn-helix domains; Region: HTH; cl00088 768492007500 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 768492007501 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 768492007502 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 768492007503 NAD(P) binding site [chemical binding]; other site 768492007504 intracellular protease, PfpI family; Region: PfpI; TIGR01382 768492007505 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 768492007506 conserved cys residue [active] 768492007507 Phosphopantetheine attachment site; Region: PP-binding; cl09936 768492007508 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 768492007509 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 768492007510 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 768492007511 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 768492007512 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 768492007513 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 768492007514 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007515 putative substrate translocation pore; other site 768492007516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007517 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492007518 Helix-turn-helix domains; Region: HTH; cl00088 768492007519 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 768492007520 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 768492007521 active site 768492007522 homotetramer interface [polypeptide binding]; other site 768492007523 homodimer interface [polypeptide binding]; other site 768492007524 benzoate transporter; Region: benE; TIGR00843 768492007525 Benzoate membrane transport protein; Region: BenE; pfam03594 768492007526 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768492007527 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492007528 DNA-binding site [nucleotide binding]; DNA binding site 768492007529 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492007530 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492007531 homodimer interface [polypeptide binding]; other site 768492007532 catalytic residue [active] 768492007533 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492007534 non-specific DNA binding site [nucleotide binding]; other site 768492007535 salt bridge; other site 768492007536 sequence-specific DNA binding site [nucleotide binding]; other site 768492007537 Cupin domain; Region: Cupin_2; cl09118 768492007538 EamA-like transporter family; Region: EamA; cl01037 768492007539 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492007540 Helix-turn-helix domains; Region: HTH; cl00088 768492007541 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768492007542 dimerization interface [polypeptide binding]; other site 768492007543 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 768492007544 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 768492007545 active site 768492007546 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 768492007547 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 768492007548 Flavin binding site [chemical binding]; other site 768492007549 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 768492007550 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 768492007551 active site 768492007552 non-prolyl cis peptide bond; other site 768492007553 NMT1-like family; Region: NMT1_2; cl15260 768492007554 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 768492007555 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 768492007556 Walker A/P-loop; other site 768492007557 ATP binding site [chemical binding]; other site 768492007558 Q-loop/lid; other site 768492007559 ABC transporter signature motif; other site 768492007560 Walker B; other site 768492007561 D-loop; other site 768492007562 H-loop/switch region; other site 768492007563 NIL domain; Region: NIL; cl09633 768492007564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492007565 dimer interface [polypeptide binding]; other site 768492007566 conserved gate region; other site 768492007567 ABC-ATPase subunit interface; other site 768492007568 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 768492007569 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492007570 substrate binding pocket [chemical binding]; other site 768492007571 membrane-bound complex binding site; other site 768492007572 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 768492007573 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 768492007574 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492007575 catalytic residue [active] 768492007576 serine O-acetyltransferase; Region: cysE; TIGR01172 768492007577 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 768492007578 trimer interface [polypeptide binding]; other site 768492007579 active site 768492007580 substrate binding site [chemical binding]; other site 768492007581 CoA binding site [chemical binding]; other site 768492007582 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 768492007583 active site residue [active] 768492007584 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 768492007585 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492007586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007587 D-galactonate transporter; Region: 2A0114; TIGR00893 768492007588 putative substrate translocation pore; other site 768492007589 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007590 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768492007591 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768492007592 putative active site [active] 768492007593 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 768492007594 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 768492007595 heterodimer interface [polypeptide binding]; other site 768492007596 multimer interface [polypeptide binding]; other site 768492007597 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 768492007598 active site 768492007599 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 768492007600 heterodimer interface [polypeptide binding]; other site 768492007601 active site 768492007602 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 768492007603 Helix-turn-helix domains; Region: HTH; cl00088 768492007604 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492007605 dimerization interface [polypeptide binding]; other site 768492007606 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 768492007607 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 768492007608 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 768492007609 tetramer interface [polypeptide binding]; other site 768492007610 active site 768492007611 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 768492007612 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492007613 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492007614 benzoate transport; Region: 2A0115; TIGR00895 768492007615 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007616 putative substrate translocation pore; other site 768492007617 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007618 benzoate transport; Region: 2A0115; TIGR00895 768492007619 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007620 putative substrate translocation pore; other site 768492007621 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007622 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 768492007623 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 768492007624 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 768492007625 shikimate binding site; other site 768492007626 NAD(P) binding site [chemical binding]; other site 768492007627 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 768492007628 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 768492007629 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 768492007630 dimer interface [polypeptide binding]; other site 768492007631 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 768492007632 active site 768492007633 Fe binding site [ion binding]; other site 768492007634 ATP-grasp domain; Region: ATP-grasp_4; cl03087 768492007635 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 768492007636 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 768492007637 Helix-turn-helix domains; Region: HTH; cl00088 768492007638 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 768492007639 Helix-turn-helix domains; Region: HTH; cl00088 768492007640 Bacterial transcriptional regulator; Region: IclR; pfam01614 768492007641 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 768492007642 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 768492007643 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492007644 catalytic residue [active] 768492007645 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 768492007646 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 768492007647 dimer interface [polypeptide binding]; other site 768492007648 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 768492007649 MASE1; Region: MASE1; pfam05231 768492007650 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 768492007651 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768492007652 metal binding site [ion binding]; metal-binding site 768492007653 active site 768492007654 I-site; other site 768492007655 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768492007656 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492007657 Coenzyme A binding pocket [chemical binding]; other site 768492007658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 768492007659 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 768492007660 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 768492007661 Walker A/P-loop; other site 768492007662 ATP binding site [chemical binding]; other site 768492007663 Q-loop/lid; other site 768492007664 ABC transporter signature motif; other site 768492007665 Walker B; other site 768492007666 D-loop; other site 768492007667 H-loop/switch region; other site 768492007668 NIL domain; Region: NIL; cl09633 768492007669 NMT1-like family; Region: NMT1_2; cl15260 768492007670 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 768492007671 L-xylulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 768492007672 putative N- and C-terminal domain interface [polypeptide binding]; other site 768492007673 putative active site [active] 768492007674 putative MgATP binding site [chemical binding]; other site 768492007675 catalytic site [active] 768492007676 metal binding site [ion binding]; metal-binding site 768492007677 putative xylulose binding site [chemical binding]; other site 768492007678 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 768492007679 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492007680 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 768492007681 substrate binding site [chemical binding]; other site 768492007682 ATP binding site [chemical binding]; other site 768492007683 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768492007684 TM-ABC transporter signature motif; other site 768492007685 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768492007686 TM-ABC transporter signature motif; other site 768492007687 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 768492007688 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 768492007689 Walker A/P-loop; other site 768492007690 ATP binding site [chemical binding]; other site 768492007691 Q-loop/lid; other site 768492007692 ABC transporter signature motif; other site 768492007693 Walker B; other site 768492007694 D-loop; other site 768492007695 H-loop/switch region; other site 768492007696 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 768492007697 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 768492007698 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 768492007699 putative ligand binding site [chemical binding]; other site 768492007700 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 768492007701 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 768492007702 Ca binding site [ion binding]; other site 768492007703 active site 768492007704 catalytic site [active] 768492007705 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 768492007706 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 768492007707 Walker A/P-loop; other site 768492007708 ATP binding site [chemical binding]; other site 768492007709 Q-loop/lid; other site 768492007710 ABC transporter signature motif; other site 768492007711 Walker B; other site 768492007712 D-loop; other site 768492007713 H-loop/switch region; other site 768492007714 TOBE domain; Region: TOBE_2; cl01440 768492007715 alpha-galactosidase; Provisional; Region: PRK15076 768492007716 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492007717 NAD(P) binding site [chemical binding]; other site 768492007718 LDH/MDH dimer interface [polypeptide binding]; other site 768492007719 substrate binding site [chemical binding]; other site 768492007720 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 768492007721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492007722 dimer interface [polypeptide binding]; other site 768492007723 conserved gate region; other site 768492007724 putative PBP binding loops; other site 768492007725 ABC-ATPase subunit interface; other site 768492007726 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 768492007727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492007728 dimer interface [polypeptide binding]; other site 768492007729 conserved gate region; other site 768492007730 putative PBP binding loops; other site 768492007731 ABC-ATPase subunit interface; other site 768492007732 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 768492007733 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492007734 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492007735 Helix-turn-helix domains; Region: HTH; cl00088 768492007736 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492007737 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768492007738 active site turn [active] 768492007739 phosphorylation site [posttranslational modification] 768492007740 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 768492007741 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 768492007742 Mechanosensitive ion channel; Region: MS_channel; pfam00924 768492007743 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 768492007744 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 768492007745 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 768492007746 Cupin domain; Region: Cupin_2; cl09118 768492007747 Cupin domain; Region: Cupin_2; cl09118 768492007748 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768492007749 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492007750 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 768492007751 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 768492007752 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 768492007753 active site 768492007754 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 768492007755 Cation efflux family; Region: Cation_efflux; cl00316 768492007756 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 768492007757 Cation efflux family; Region: Cation_efflux; cl00316 768492007758 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 768492007759 Divalent cation transporter; Region: MgtE; cl00786 768492007760 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 768492007761 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 768492007762 peptide binding site [polypeptide binding]; other site 768492007763 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768492007764 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 768492007765 active site 768492007766 metal binding site [ion binding]; metal-binding site 768492007767 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768492007768 Helix-turn-helix domains; Region: HTH; cl00088 768492007769 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492007770 dimerization interface [polypeptide binding]; other site 768492007771 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 768492007772 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492007773 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 768492007774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492007775 dimer interface [polypeptide binding]; other site 768492007776 conserved gate region; other site 768492007777 putative PBP binding loops; other site 768492007778 ABC-ATPase subunit interface; other site 768492007779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492007780 dimer interface [polypeptide binding]; other site 768492007781 conserved gate region; other site 768492007782 putative PBP binding loops; other site 768492007783 ABC-ATPase subunit interface; other site 768492007784 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 768492007785 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 768492007786 Walker A/P-loop; other site 768492007787 ATP binding site [chemical binding]; other site 768492007788 Q-loop/lid; other site 768492007789 ABC transporter signature motif; other site 768492007790 Walker B; other site 768492007791 D-loop; other site 768492007792 H-loop/switch region; other site 768492007793 elongation factor G; Reviewed; Region: PRK00007 768492007794 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 768492007795 G1 box; other site 768492007796 putative GEF interaction site [polypeptide binding]; other site 768492007797 GTP/Mg2+ binding site [chemical binding]; other site 768492007798 Switch I region; other site 768492007799 G2 box; other site 768492007800 G3 box; other site 768492007801 Switch II region; other site 768492007802 G4 box; other site 768492007803 G5 box; other site 768492007804 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 768492007805 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 768492007806 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 768492007807 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; cl01461 768492007808 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 768492007809 GIY-YIG motif/motif A; other site 768492007810 Helix-turn-helix domains; Region: HTH; cl00088 768492007811 Cupin domain; Region: Cupin_2; cl09118 768492007812 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492007813 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768492007814 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 768492007815 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 768492007816 tetramerization interface [polypeptide binding]; other site 768492007817 NAD(P) binding site [chemical binding]; other site 768492007818 catalytic residues [active] 768492007819 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 768492007820 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768492007821 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 768492007822 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 768492007823 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492007824 Helix-turn-helix domains; Region: HTH; cl00088 768492007825 Cupin domain; Region: Cupin_2; cl09118 768492007826 K+ potassium transporter; Region: K_trans; cl15781 768492007827 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768492007828 Helix-turn-helix domains; Region: HTH; cl00088 768492007829 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 768492007830 dimerization interface [polypeptide binding]; other site 768492007831 substrate binding pocket [chemical binding]; other site 768492007832 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 768492007833 TM-ABC transporter signature motif; other site 768492007834 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 768492007835 TM-ABC transporter signature motif; other site 768492007836 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 768492007837 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 768492007838 Walker A/P-loop; other site 768492007839 ATP binding site [chemical binding]; other site 768492007840 Q-loop/lid; other site 768492007841 ABC transporter signature motif; other site 768492007842 Walker B; other site 768492007843 D-loop; other site 768492007844 H-loop/switch region; other site 768492007845 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 768492007846 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 768492007847 Walker A/P-loop; other site 768492007848 ATP binding site [chemical binding]; other site 768492007849 Q-loop/lid; other site 768492007850 ABC transporter signature motif; other site 768492007851 Walker B; other site 768492007852 D-loop; other site 768492007853 H-loop/switch region; other site 768492007854 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 768492007855 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 768492007856 dimerization interface [polypeptide binding]; other site 768492007857 ligand binding site [chemical binding]; other site 768492007858 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 768492007859 allantoate amidohydrolase; Reviewed; Region: PRK09290 768492007860 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 768492007861 active site 768492007862 metal binding site [ion binding]; metal-binding site 768492007863 dimer interface [polypeptide binding]; other site 768492007864 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768492007865 dimerization interface [polypeptide binding]; other site 768492007866 putative DNA binding site [nucleotide binding]; other site 768492007867 putative Zn2+ binding site [ion binding]; other site 768492007868 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 768492007869 putative hydrophobic ligand binding site [chemical binding]; other site 768492007870 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 768492007871 Phosphate transporter family; Region: PHO4; cl00396 768492007872 Phosphate transporter family; Region: PHO4; cl00396 768492007873 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 768492007874 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 768492007875 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 768492007876 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 768492007877 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 768492007878 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492007879 DNA-binding site [nucleotide binding]; DNA binding site 768492007880 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768492007881 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492007882 catalytic residue [active] 768492007883 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 768492007884 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 768492007885 catalytic triad [active] 768492007886 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 768492007887 dimer interface [polypeptide binding]; other site 768492007888 pyridoxamine kinase; Validated; Region: PRK05756 768492007889 pyridoxal binding site [chemical binding]; other site 768492007890 ATP binding site [chemical binding]; other site 768492007891 Flagellar regulator YcgR; Region: YcgR; pfam07317 768492007892 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 768492007893 PilZ domain; Region: PilZ; cl01260 768492007894 N-formylglutamate amidohydrolase; Region: FGase; cl01522 768492007895 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 768492007896 putative acyl-acceptor binding pocket; other site 768492007897 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 768492007898 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 768492007899 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 768492007900 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 768492007901 DNA binding site [nucleotide binding] 768492007902 active site 768492007903 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 768492007904 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 768492007905 ligand binding site [chemical binding]; other site 768492007906 flexible hinge region; other site 768492007907 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 768492007908 putative switch regulator; other site 768492007909 non-specific DNA interactions [nucleotide binding]; other site 768492007910 DNA binding site [nucleotide binding] 768492007911 sequence specific DNA binding site [nucleotide binding]; other site 768492007912 putative cAMP binding site [chemical binding]; other site 768492007913 universal stress protein UspE; Provisional; Region: PRK11175 768492007914 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 768492007915 Ligand Binding Site [chemical binding]; other site 768492007916 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 768492007917 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 768492007918 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 768492007919 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 768492007920 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 768492007921 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492007922 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 768492007923 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 768492007924 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 768492007925 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 768492007926 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 768492007927 dihydromonapterin reductase; Provisional; Region: PRK06483 768492007928 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492007929 NAD(P) binding site [chemical binding]; other site 768492007930 active site 768492007931 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 768492007932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492007933 active site 768492007934 phosphorylation site [posttranslational modification] 768492007935 intermolecular recognition site; other site 768492007936 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768492007937 DNA binding site [nucleotide binding] 768492007938 sensor protein RstB; Provisional; Region: PRK10604 768492007939 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 768492007940 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492007941 dimer interface [polypeptide binding]; other site 768492007942 phosphorylation site [posttranslational modification] 768492007943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492007944 ATP binding site [chemical binding]; other site 768492007945 Mg2+ binding site [ion binding]; other site 768492007946 G-X-G motif; other site 768492007947 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 768492007948 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 768492007949 active site 768492007950 Zn binding site [ion binding]; other site 768492007951 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 768492007952 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 768492007953 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 768492007954 active site 768492007955 substrate binding sites [chemical binding]; other site 768492007956 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 768492007957 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768492007958 ATP binding site [chemical binding]; other site 768492007959 putative Mg++ binding site [ion binding]; other site 768492007960 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768492007961 nucleotide binding region [chemical binding]; other site 768492007962 ATP-binding site [chemical binding]; other site 768492007963 Helicase associated domain (HA2); Region: HA2; cl04503 768492007964 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 768492007965 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 768492007966 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 768492007967 Protein of unknown function (DUF1318); Region: DUF1318; cl01547 768492007968 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 768492007969 Dicarboxylate transport; Region: DctA-YdbH; cl14674 768492007970 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 768492007971 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492007972 META domain; Region: META; cl01245 768492007973 Domain of unknown function (DUF333); Region: DUF333; pfam03891 768492007974 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 768492007975 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 768492007976 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 768492007977 dimer interface [polypeptide binding]; other site 768492007978 PYR/PP interface [polypeptide binding]; other site 768492007979 TPP binding site [chemical binding]; other site 768492007980 substrate binding site [chemical binding]; other site 768492007981 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 768492007982 Domain of unknown function; Region: EKR; cl11037 768492007983 4Fe-4S binding domain; Region: Fer4; cl02805 768492007984 4Fe-4S binding domain; Region: Fer4; cl02805 768492007985 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 768492007986 TPP-binding site [chemical binding]; other site 768492007987 dimer interface [polypeptide binding]; other site 768492007988 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 768492007989 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492007990 non-specific DNA binding site [nucleotide binding]; other site 768492007991 salt bridge; other site 768492007992 sequence-specific DNA binding site [nucleotide binding]; other site 768492007993 Cupin domain; Region: Cupin_2; cl09118 768492007994 B3/4 domain; Region: B3_4; cl11458 768492007995 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 768492007996 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 768492007997 Ligand Binding Site [chemical binding]; other site 768492007998 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 768492007999 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768492008000 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 768492008001 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 768492008002 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 768492008003 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 768492008004 peptide binding site [polypeptide binding]; other site 768492008005 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 768492008006 active site 768492008007 Zn binding site [ion binding]; other site 768492008008 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 768492008009 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 768492008010 active site 768492008011 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 768492008012 dimer interface [polypeptide binding]; other site 768492008013 catalytic triad [active] 768492008014 peroxidatic and resolving cysteines [active] 768492008015 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 768492008016 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 768492008017 putative aromatic amino acid binding site; other site 768492008018 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 768492008019 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492008020 Walker A motif; other site 768492008021 ATP binding site [chemical binding]; other site 768492008022 Walker B motif; other site 768492008023 arginine finger; other site 768492008024 hypothetical protein; Provisional; Region: PRK05415 768492008025 Domain of unknown function (DUF697); Region: DUF697; cl12064 768492008026 YcjX-like family, DUF463; Region: DUF463; cl01193 768492008027 Phage shock protein PspD (Phageshock_PspD); Region: Phageshock_PspD; cl11512 768492008028 PspC domain; Region: PspC; cl00864 768492008029 phage shock protein C; Region: phageshock_pspC; TIGR02978 768492008030 Phage shock protein B; Region: PspB; cl05946 768492008031 phage shock protein PspA; Provisional; Region: PRK10698 768492008032 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 768492008033 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492008034 Walker A motif; other site 768492008035 ATP binding site [chemical binding]; other site 768492008036 Walker B motif; other site 768492008037 arginine finger; other site 768492008038 Helix-turn-helix domains; Region: HTH; cl00088 768492008039 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 768492008040 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492008041 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 768492008042 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 768492008043 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 768492008044 trimer interface [polypeptide binding]; other site 768492008045 active site 768492008046 Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642 768492008047 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 768492008048 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 768492008049 peptide binding site [polypeptide binding]; other site 768492008050 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 768492008051 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492008052 dimer interface [polypeptide binding]; other site 768492008053 conserved gate region; other site 768492008054 putative PBP binding loops; other site 768492008055 ABC-ATPase subunit interface; other site 768492008056 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 768492008057 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 768492008058 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492008059 dimer interface [polypeptide binding]; other site 768492008060 conserved gate region; other site 768492008061 putative PBP binding loops; other site 768492008062 ABC-ATPase subunit interface; other site 768492008063 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 768492008064 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 768492008065 Walker A/P-loop; other site 768492008066 ATP binding site [chemical binding]; other site 768492008067 Q-loop/lid; other site 768492008068 ABC transporter signature motif; other site 768492008069 Walker B; other site 768492008070 D-loop; other site 768492008071 H-loop/switch region; other site 768492008072 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768492008073 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 768492008074 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 768492008075 Walker A/P-loop; other site 768492008076 ATP binding site [chemical binding]; other site 768492008077 Q-loop/lid; other site 768492008078 ABC transporter signature motif; other site 768492008079 Walker B; other site 768492008080 D-loop; other site 768492008081 H-loop/switch region; other site 768492008082 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 768492008083 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 768492008084 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 768492008085 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492008086 Helix-turn-helix domains; Region: HTH; cl00088 768492008087 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768492008088 dimerization interface [polypeptide binding]; other site 768492008089 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 768492008090 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 768492008091 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 768492008092 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 768492008093 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 768492008094 putative molybdopterin cofactor binding site [chemical binding]; other site 768492008095 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 768492008096 putative molybdopterin cofactor binding site; other site 768492008097 exoribonuclease II; Provisional; Region: PRK05054 768492008098 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 768492008099 RNB domain; Region: RNB; pfam00773 768492008100 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 768492008101 carbon starvation protein A; Provisional; Region: PRK15015 768492008102 Carbon starvation protein CstA; Region: CstA; pfam02554 768492008103 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 768492008104 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 768492008105 active site 768492008106 intersubunit interactions; other site 768492008107 catalytic residue [active] 768492008108 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 768492008109 Helix-turn-helix domains; Region: HTH; cl00088 768492008110 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 768492008111 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 768492008112 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 768492008113 intersubunit interface [polypeptide binding]; other site 768492008114 active site 768492008115 Zn2+ binding site [ion binding]; other site 768492008116 lipoprotein; Provisional; Region: PRK10540 768492008117 translation initiation factor Sui1; Validated; Region: PRK06824 768492008118 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 768492008119 putative rRNA binding site [nucleotide binding]; other site 768492008120 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 768492008121 active site 768492008122 dimer interface [polypeptide binding]; other site 768492008123 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 768492008124 tetratricopeptide repeat protein; Provisional; Region: PRK11788 768492008125 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 768492008126 TPR motif; other site 768492008127 binding surface 768492008128 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 768492008129 binding surface 768492008130 TPR motif; other site 768492008131 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 768492008132 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 768492008133 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 768492008134 active site 768492008135 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 768492008136 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 768492008137 dimerization interface [polypeptide binding]; other site 768492008138 active site 768492008139 aconitate hydratase; Validated; Region: PRK09277 768492008140 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 768492008141 substrate binding site [chemical binding]; other site 768492008142 ligand binding site [chemical binding]; other site 768492008143 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 768492008144 substrate binding site [chemical binding]; other site 768492008145 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 768492008146 Helix-turn-helix domains; Region: HTH; cl00088 768492008147 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 768492008148 substrate binding site [chemical binding]; other site 768492008149 putative dimerization interface [polypeptide binding]; other site 768492008150 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 768492008151 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 768492008152 active site 768492008153 interdomain interaction site; other site 768492008154 putative metal-binding site [ion binding]; other site 768492008155 nucleotide binding site [chemical binding]; other site 768492008156 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 768492008157 domain I; other site 768492008158 DNA binding groove [nucleotide binding] 768492008159 phosphate binding site [ion binding]; other site 768492008160 domain II; other site 768492008161 domain III; other site 768492008162 nucleotide binding site [chemical binding]; other site 768492008163 catalytic site [active] 768492008164 domain IV; other site 768492008165 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 768492008166 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 768492008167 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 768492008168 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 768492008169 Protein of unknown function (DUF2498); Region: DUF2498; cl11671 768492008170 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 768492008171 putative inner membrane peptidase; Provisional; Region: PRK11778 768492008172 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 768492008173 tandem repeat interface [polypeptide binding]; other site 768492008174 oligomer interface [polypeptide binding]; other site 768492008175 active site residues [active] 768492008176 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 768492008177 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 768492008178 NADP binding site [chemical binding]; other site 768492008179 homodimer interface [polypeptide binding]; other site 768492008180 active site 768492008181 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 768492008182 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492008183 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 768492008184 homodimer interface [polypeptide binding]; other site 768492008185 Walker A motif; other site 768492008186 ATP binding site [chemical binding]; other site 768492008187 hydroxycobalamin binding site [chemical binding]; other site 768492008188 Walker B motif; other site 768492008189 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 768492008190 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768492008191 RNA binding surface [nucleotide binding]; other site 768492008192 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 768492008193 probable active site [active] 768492008194 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768492008195 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 768492008196 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 768492008197 anthranilate synthase component I; Provisional; Region: PRK13564 768492008198 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 768492008199 chorismate binding enzyme; Region: Chorismate_bind; cl10555 768492008200 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 768492008201 Glutamine amidotransferase class-I; Region: GATase; pfam00117 768492008202 glutamine binding [chemical binding]; other site 768492008203 catalytic triad [active] 768492008204 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 768492008205 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 768492008206 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 768492008207 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 768492008208 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 768492008209 active site 768492008210 ribulose/triose binding site [chemical binding]; other site 768492008211 phosphate binding site [ion binding]; other site 768492008212 substrate (anthranilate) binding pocket [chemical binding]; other site 768492008213 product (indole) binding pocket [chemical binding]; other site 768492008214 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 768492008215 active site 768492008216 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 768492008217 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 768492008218 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492008219 catalytic residue [active] 768492008220 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 768492008221 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 768492008222 substrate binding site [chemical binding]; other site 768492008223 active site 768492008224 catalytic residues [active] 768492008225 heterodimer interface [polypeptide binding]; other site 768492008226 BON domain; Region: BON; cl02771 768492008227 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 768492008228 Flagellin N-methylase; Region: FliB; cl00497 768492008229 Uncharacterized protein family (UPF0259); Region: UPF0259; cl11642 768492008230 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 768492008231 Sulfate transporter family; Region: Sulfate_transp; cl15842 768492008232 Sulfate transporter family; Region: Sulfate_transp; cl15842 768492008233 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 768492008234 Intracellular septation protein A; Region: IspA; cl01098 768492008235 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 768492008236 transport protein TonB; Provisional; Region: PRK10819 768492008237 Gram-negative bacterial tonB protein; Region: TonB; cl10048 768492008238 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 768492008239 YCII-related domain; Region: YCII; cl00999 768492008240 Head binding; Region: Head_binding; pfam09008 768492008241 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 768492008242 active site 768492008243 Mnt; Region: mnt; PHA01513 768492008244 Arc-like DNA binding domain; Region: Arc; pfam03869 768492008245 Regulatory protein Mnt; Region: Repressor_Mnt; pfam11423 768492008246 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 768492008247 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 768492008248 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768492008249 catalytic residue [active] 768492008250 Protein of unknown function (DUF2824); Region: DUF2824; cl10279 768492008251 Phage stabilisation protein; Region: Phage_stabilise; pfam11134 768492008252 P22 tail accessory factor; Region: P22_Tail-4; pfam11650 768492008253 P22 coat protein - gene protein 5; Region: P22_CoatProtein; cl10302 768492008254 Bacteriophage, scaffolding protein; Region: Phage-scaffold; pfam09306 768492008255 Terminase-like family; Region: Terminase_6; pfam03237 768492008256 Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565 768492008257 Terminase small subunit; Region: Terminase_2; cl01513 768492008258 Protein of unknown function (DUF2560); Region: DUF2560; cl10280 768492008259 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 768492008260 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 768492008261 catalytic residue [active] 768492008262 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 768492008263 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 768492008264 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 768492008265 polymerase nucleotide-binding site; other site 768492008266 DNA-binding residues [nucleotide binding]; DNA binding site 768492008267 nucleotide binding site [chemical binding]; other site 768492008268 primase nucleotide-binding site [nucleotide binding]; other site 768492008269 Virulence-associated protein E; Region: VirE; pfam05272 768492008270 putative Cro-like protein; Region: PHA00542 768492008271 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 768492008272 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 768492008273 Catalytic site [active] 768492008274 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 768492008275 hypothetical protein; Provisional; Region: PRK09946 768492008276 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 768492008277 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 768492008278 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 768492008279 active site 768492008280 substrate binding site [chemical binding]; other site 768492008281 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 768492008282 active site 768492008283 DNA binding site [nucleotide binding] 768492008284 catalytic site [active] 768492008285 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 768492008286 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 768492008287 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492008288 ATP binding site [chemical binding]; other site 768492008289 putative Mg++ binding site [ion binding]; other site 768492008290 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768492008291 nucleotide binding region [chemical binding]; other site 768492008292 ATP-binding site [chemical binding]; other site 768492008293 integrase; Provisional; Region: PRK09692 768492008294 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 768492008295 active site 768492008296 Int/Topo IB signature motif; other site 768492008297 KTSC domain; Region: KTSC; pfam13619 768492008298 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492008299 Helix-turn-helix domains; Region: HTH; cl00088 768492008300 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 768492008301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492008302 putative substrate translocation pore; other site 768492008303 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 768492008304 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 768492008305 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 768492008306 putative active site [active] 768492008307 catalytic site [active] 768492008308 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 768492008309 putative active site [active] 768492008310 catalytic site [active] 768492008311 Protein of unknown function, DUF440; Region: DUF440; cl11472 768492008312 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 768492008313 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 768492008314 Walker A/P-loop; other site 768492008315 ATP binding site [chemical binding]; other site 768492008316 Q-loop/lid; other site 768492008317 ABC transporter signature motif; other site 768492008318 Walker B; other site 768492008319 D-loop; other site 768492008320 H-loop/switch region; other site 768492008321 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768492008322 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 768492008323 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 768492008324 Walker A/P-loop; other site 768492008325 ATP binding site [chemical binding]; other site 768492008326 Q-loop/lid; other site 768492008327 ABC transporter signature motif; other site 768492008328 Walker B; other site 768492008329 D-loop; other site 768492008330 H-loop/switch region; other site 768492008331 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768492008332 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 768492008333 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 768492008334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492008335 dimer interface [polypeptide binding]; other site 768492008336 conserved gate region; other site 768492008337 ABC-ATPase subunit interface; other site 768492008338 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 768492008339 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492008340 dimer interface [polypeptide binding]; other site 768492008341 conserved gate region; other site 768492008342 putative PBP binding loops; other site 768492008343 ABC-ATPase subunit interface; other site 768492008344 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 768492008345 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 768492008346 peptide binding site [polypeptide binding]; other site 768492008347 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 768492008348 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 768492008349 peptide binding site [polypeptide binding]; other site 768492008350 MarC family integral membrane protein; Region: MarC; cl00919 768492008351 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 768492008352 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 768492008353 putative catalytic cysteine [active] 768492008354 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 768492008355 putative active site [active] 768492008356 metal binding site [ion binding]; metal-binding site 768492008357 thymidine kinase; Provisional; Region: PRK04296 768492008358 Uncharacterized conserved protein (DUF2217); Region: DUF2217; pfam10265 768492008359 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 768492008360 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 768492008361 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768492008362 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 768492008363 putative NAD(P) binding site [chemical binding]; other site 768492008364 active site 768492008365 putative substrate binding site [chemical binding]; other site 768492008366 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 768492008367 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492008368 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 768492008369 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492008370 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 768492008371 active site 768492008372 tetramer interface; other site 768492008373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492008374 active site 768492008375 response regulator of RpoS; Provisional; Region: PRK10693 768492008376 phosphorylation site [posttranslational modification] 768492008377 intermolecular recognition site; other site 768492008378 dimerization interface [polypeptide binding]; other site 768492008379 hypothetical protein; Provisional; Region: PRK10279 768492008380 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 768492008381 nucleophile elbow; other site 768492008382 hypothetical protein; Provisional; Region: PRK01617 768492008383 SEC-C motif; Region: SEC-C; pfam02810 768492008384 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 768492008385 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 768492008386 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 768492008387 putative active site [active] 768492008388 putative substrate binding site [chemical binding]; other site 768492008389 putative cosubstrate binding site; other site 768492008390 catalytic site [active] 768492008391 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 768492008392 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 768492008393 putative catalytic site [active] 768492008394 putative phosphate binding site [ion binding]; other site 768492008395 active site 768492008396 metal binding site A [ion binding]; metal-binding site 768492008397 DNA binding site [nucleotide binding] 768492008398 putative AP binding site [nucleotide binding]; other site 768492008399 putative metal binding site B [ion binding]; other site 768492008400 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 768492008401 active site 768492008402 8-oxo-dGMP binding site [chemical binding]; other site 768492008403 nudix motif; other site 768492008404 metal binding site [ion binding]; metal-binding site 768492008405 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 768492008406 DNA topoisomerase III; Provisional; Region: PRK07726 768492008407 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 768492008408 active site 768492008409 putative interdomain interaction site [polypeptide binding]; other site 768492008410 putative metal-binding site [ion binding]; other site 768492008411 putative nucleotide binding site [chemical binding]; other site 768492008412 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 768492008413 domain I; other site 768492008414 DNA binding groove [nucleotide binding] 768492008415 phosphate binding site [ion binding]; other site 768492008416 domain II; other site 768492008417 domain III; other site 768492008418 nucleotide binding site [chemical binding]; other site 768492008419 catalytic site [active] 768492008420 domain IV; other site 768492008421 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 768492008422 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 768492008423 active site residue [active] 768492008424 selenophosphate synthetase; Provisional; Region: PRK00943 768492008425 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 768492008426 dimerization interface [polypeptide binding]; other site 768492008427 putative ATP binding site [chemical binding]; other site 768492008428 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 768492008429 putative FMN binding site [chemical binding]; other site 768492008430 protease 4; Provisional; Region: PRK10949 768492008431 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 768492008432 tandem repeat interface [polypeptide binding]; other site 768492008433 oligomer interface [polypeptide binding]; other site 768492008434 active site residues [active] 768492008435 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 768492008436 tandem repeat interface [polypeptide binding]; other site 768492008437 oligomer interface [polypeptide binding]; other site 768492008438 active site residues [active] 768492008439 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 768492008440 active site 768492008441 homodimer interface [polypeptide binding]; other site 768492008442 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 768492008443 Isochorismatase family; Region: Isochorismatase; pfam00857 768492008444 catalytic triad [active] 768492008445 metal binding site [ion binding]; metal-binding site 768492008446 conserved cis-peptide bond; other site 768492008447 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 768492008448 Glyco_18 domain; Region: Glyco_18; smart00636 768492008449 active site 768492008450 Protein of unknown function (DUF1315); Region: DUF1315; cl01215 768492008451 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 768492008452 SelR domain; Region: SelR; pfam01641 768492008453 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 768492008454 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492008455 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 768492008456 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 768492008457 active site 768492008458 phosphate binding residues; other site 768492008459 catalytic residues [active] 768492008460 MltA-interacting protein MipA; Region: MipA; cl01504 768492008461 PrkA family serine protein kinase; Provisional; Region: PRK15455 768492008462 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492008463 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 768492008464 Uncharacterized conserved protein [Function unknown]; Region: COG2718 768492008465 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 768492008466 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492008467 Coenzyme A binding pocket [chemical binding]; other site 768492008468 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 768492008469 intracellular protease, PfpI family; Region: PfpI; TIGR01382 768492008470 conserved cys residue [active] 768492008471 Proteolipid membrane potential modulator; Region: Pmp3; cl00431 768492008472 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 768492008473 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 768492008474 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768492008475 N-terminal plug; other site 768492008476 ligand-binding site [chemical binding]; other site 768492008477 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 768492008478 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 768492008479 Walker A/P-loop; other site 768492008480 ATP binding site [chemical binding]; other site 768492008481 Q-loop/lid; other site 768492008482 ABC transporter signature motif; other site 768492008483 Walker B; other site 768492008484 D-loop; other site 768492008485 H-loop/switch region; other site 768492008486 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 768492008487 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 768492008488 Walker A/P-loop; other site 768492008489 ATP binding site [chemical binding]; other site 768492008490 Q-loop/lid; other site 768492008491 ABC transporter signature motif; other site 768492008492 Walker B; other site 768492008493 D-loop; other site 768492008494 H-loop/switch region; other site 768492008495 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768492008496 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 768492008497 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 768492008498 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 768492008499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 768492008500 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 768492008501 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 768492008502 active site 768492008503 substrate binding site [chemical binding]; other site 768492008504 catalytic site [active] 768492008505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492008506 putative substrate translocation pore; other site 768492008507 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768492008508 alanine racemase; Reviewed; Region: dadX; PRK03646 768492008509 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 768492008510 active site 768492008511 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768492008512 substrate binding site [chemical binding]; other site 768492008513 catalytic residues [active] 768492008514 dimer interface [polypeptide binding]; other site 768492008515 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 768492008516 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492008517 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 768492008518 active site 768492008519 catalytic triad [active] 768492008520 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 768492008521 Baseplate J-like protein; Region: Baseplate_J; cl01294 768492008522 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 768492008523 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 768492008524 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768492008525 catalytic residue [active] 768492008526 Protein of unknown function (DUF3277); Region: DUF3277; pfam11681 768492008527 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 768492008528 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 768492008529 Encapsulating protein for peroxidase; Region: Linocin_M18; cl12047 768492008530 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 768492008531 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; cl15403 768492008532 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 768492008533 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567; cl12082 768492008534 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 768492008535 Terminase small subunit; Region: Terminase_2; cl01513 768492008536 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 768492008537 catalytic residue [active] 768492008538 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 768492008539 Poxvirus G5 protein; Region: Pox_G5; pfam04599 768492008540 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 768492008541 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 768492008542 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 768492008543 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 768492008544 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 768492008545 cofactor binding site; other site 768492008546 DNA binding site [nucleotide binding] 768492008547 substrate interaction site [chemical binding]; other site 768492008548 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 768492008549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 768492008550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 768492008551 replicative DNA helicase; Region: DnaB; TIGR00665 768492008552 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 768492008553 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 768492008554 Walker A motif; other site 768492008555 ATP binding site [chemical binding]; other site 768492008556 Walker B motif; other site 768492008557 DNA binding loops [nucleotide binding] 768492008558 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 768492008559 transcriptional repressor DicA; Reviewed; Region: PRK09706 768492008560 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492008561 non-specific DNA binding site [nucleotide binding]; other site 768492008562 salt bridge; other site 768492008563 sequence-specific DNA binding site [nucleotide binding]; other site 768492008564 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 768492008565 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 768492008566 Excisionase-like protein; Region: Exc; pfam07825 768492008567 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768492008568 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 768492008569 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 768492008570 dimer interface [polypeptide binding]; other site 768492008571 active site 768492008572 Int/Topo IB signature motif; other site 768492008573 SpoVR family protein; Provisional; Region: PRK11767 768492008574 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 768492008575 fatty acid metabolism regulator; Provisional; Region: PRK04984 768492008576 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492008577 DNA-binding site [nucleotide binding]; DNA binding site 768492008578 FCD domain; Region: FCD; cl11656 768492008579 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 768492008580 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 768492008581 Flagellin N-methylase; Region: FliB; cl00497 768492008582 CsbD-like; Region: CsbD; cl15799 768492008583 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 768492008584 Transglycosylase SLT domain; Region: SLT_2; pfam13406 768492008585 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 768492008586 YcgL domain; Region: YcgL; cl01189 768492008587 septum formation inhibitor; Reviewed; Region: minC; PRK03511 768492008588 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 768492008589 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 768492008590 cell division inhibitor MinD; Provisional; Region: PRK10818 768492008591 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 768492008592 Switch I; other site 768492008593 Switch II; other site 768492008594 Septum formation topological specificity factor MinE; Region: MinE; cl00538 768492008595 ribonuclease D; Provisional; Region: PRK10829 768492008596 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 768492008597 catalytic site [active] 768492008598 putative active site [active] 768492008599 putative substrate binding site [chemical binding]; other site 768492008600 HRDC domain; Region: HRDC; cl02578 768492008601 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 768492008602 AMP-binding enzyme; Region: AMP-binding; cl15778 768492008603 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 768492008604 Outer membrane lipoprotein Slp family; Region: Slp; cl01164 768492008605 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 768492008606 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 768492008607 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492008608 DEAD_2; Region: DEAD_2; pfam06733 768492008609 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492008610 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 768492008611 homotrimer interaction site [polypeptide binding]; other site 768492008612 putative active site [active] 768492008613 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 768492008614 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 768492008615 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 768492008616 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 768492008617 active site 768492008618 intersubunit interface [polypeptide binding]; other site 768492008619 catalytic residue [active] 768492008620 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 768492008621 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 768492008622 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 768492008623 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 768492008624 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768492008625 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768492008626 putative active site [active] 768492008627 pyruvate kinase; Provisional; Region: PRK05826 768492008628 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 768492008629 domain interfaces; other site 768492008630 active site 768492008631 leucine-rich repeat receptor-like protein kinase; Provisional; Region: PLN00113 768492008632 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 768492008633 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 768492008634 putative acyl-acceptor binding pocket; other site 768492008635 putative peptidase; Provisional; Region: PRK11649 768492008636 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 768492008637 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 768492008638 putative peptidoglycan binding site; other site 768492008639 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 768492008640 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 768492008641 metal binding site [ion binding]; metal-binding site 768492008642 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 768492008643 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 768492008644 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768492008645 ABC-ATPase subunit interface; other site 768492008646 dimer interface [polypeptide binding]; other site 768492008647 putative PBP binding regions; other site 768492008648 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 768492008649 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492008650 Walker A motif; other site 768492008651 ATP binding site [chemical binding]; other site 768492008652 Walker B motif; other site 768492008653 arginine finger; other site 768492008654 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 768492008655 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 768492008656 RuvA N terminal domain; Region: RuvA_N; pfam01330 768492008657 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 768492008658 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 768492008659 active site 768492008660 putative DNA-binding cleft [nucleotide binding]; other site 768492008661 dimer interface [polypeptide binding]; other site 768492008662 Transcriptional regulator; Region: Transcrip_reg; cl00361 768492008663 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 768492008664 nudix motif; other site 768492008665 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 768492008666 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 768492008667 dimer interface [polypeptide binding]; other site 768492008668 anticodon binding site; other site 768492008669 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 768492008670 homodimer interface [polypeptide binding]; other site 768492008671 motif 1; other site 768492008672 active site 768492008673 motif 2; other site 768492008674 GAD domain; Region: GAD; pfam02938 768492008675 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 768492008676 active site 768492008677 motif 3; other site 768492008678 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 768492008679 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 768492008680 Isochorismatase family; Region: Isochorismatase; pfam00857 768492008681 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 768492008682 catalytic triad [active] 768492008683 conserved cis-peptide bond; other site 768492008684 Protein of unknown function DUF72; Region: DUF72; cl00777 768492008685 MAPEG family; Region: MAPEG; cl09190 768492008686 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492008687 S-adenosylmethionine binding site [chemical binding]; other site 768492008688 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 768492008689 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 768492008690 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 768492008691 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 768492008692 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 768492008693 CutC family; Region: CutC; cl01218 768492008694 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 768492008695 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492008696 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492008697 homodimer interface [polypeptide binding]; other site 768492008698 catalytic residue [active] 768492008699 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 768492008700 putative metal binding site [ion binding]; other site 768492008701 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 768492008702 arginyl-tRNA synthetase; Region: argS; TIGR00456 768492008703 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 768492008704 active site 768492008705 HIGH motif; other site 768492008706 KMSK motif region; other site 768492008707 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 768492008708 tRNA binding surface [nucleotide binding]; other site 768492008709 anticodon binding site; other site 768492008710 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 768492008711 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768492008712 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492008713 hypothetical protein; Provisional; Region: PRK11239 768492008714 Protein of unknown function, DUF480; Region: DUF480; cl01209 768492008715 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 768492008716 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 768492008717 multidrug resistance protein MdtH; Provisional; Region: PRK11646 768492008718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492008719 putative substrate translocation pore; other site 768492008720 glutaredoxin 2; Provisional; Region: PRK10387 768492008721 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 768492008722 C-terminal domain interface [polypeptide binding]; other site 768492008723 GSH binding site (G-site) [chemical binding]; other site 768492008724 catalytic residues [active] 768492008725 putative dimer interface [polypeptide binding]; other site 768492008726 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 768492008727 N-terminal domain interface [polypeptide binding]; other site 768492008728 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 768492008729 Protein of unknown function (DUF1439); Region: DUF1439; cl06345 768492008730 YebF-like protein; Region: YebF; cl10126 768492008731 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 768492008732 YebG protein; Region: YebG; cl01217 768492008733 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 768492008734 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 768492008735 ATP binding site [chemical binding]; other site 768492008736 Mg++ binding site [ion binding]; other site 768492008737 motif III; other site 768492008738 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768492008739 nucleotide binding region [chemical binding]; other site 768492008740 ATP-binding site [chemical binding]; other site 768492008741 DbpA RNA binding domain; Region: DbpA; pfam03880 768492008742 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 768492008743 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 768492008744 ATP-grasp domain; Region: ATP-grasp_4; cl03087 768492008745 Uncharacterized protein family (UPF0181); Region: UPF0181; cl11477 768492008746 putative glycosyl transferase; Provisional; Region: PRK10073 768492008747 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 768492008748 active site 768492008749 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 768492008750 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 768492008751 chorismate binding enzyme; Region: Chorismate_bind; cl10555 768492008752 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 768492008753 putative active site [active] 768492008754 putative CoA binding site [chemical binding]; other site 768492008755 nudix motif; other site 768492008756 metal binding site [ion binding]; metal-binding site 768492008757 L-serine deaminase; Provisional; Region: PRK15023 768492008758 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 768492008759 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 768492008760 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 768492008761 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 768492008762 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768492008763 Integral membrane protein TerC family; Region: TerC; cl10468 768492008764 FOG: CBS domain [General function prediction only]; Region: COG0517 768492008765 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 768492008766 Transporter associated domain; Region: CorC_HlyC; cl08393 768492008767 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 768492008768 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 768492008769 active pocket/dimerization site; other site 768492008770 active site 768492008771 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 768492008772 active site 768492008773 phosphorylation site [posttranslational modification] 768492008774 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 768492008775 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 768492008776 Protein of unknown function (DUF986); Region: DUF986; cl01983 768492008777 Domain of unknown function DUF; Region: DUF204; pfam02659 768492008778 Domain of unknown function DUF; Region: DUF204; pfam02659 768492008779 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 768492008780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492008781 putative substrate translocation pore; other site 768492008782 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768492008783 dimerization interface [polypeptide binding]; other site 768492008784 putative DNA binding site [nucleotide binding]; other site 768492008785 putative Zn2+ binding site [ion binding]; other site 768492008786 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 768492008787 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492008788 S-adenosylmethionine binding site [chemical binding]; other site 768492008789 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 768492008790 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 768492008791 DNA-binding site [nucleotide binding]; DNA binding site 768492008792 RNA-binding motif; other site 768492008793 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 768492008794 aromatic amino acid transporter; Provisional; Region: PRK10238 768492008795 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 768492008796 Protein of unknown function (DUF2591); Region: DUF2591; cl11584 768492008797 FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244 768492008798 dimer interface [polypeptide binding]; other site 768492008799 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768492008800 Mn binding site [ion binding]; other site 768492008801 K binding site [ion binding]; other site 768492008802 YebO-like protein; Region: YebO; pfam13974 768492008803 YobH-like protein; Region: YobH; pfam13996 768492008804 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 768492008805 YccJ-like protein; Region: YccJ; cl08091 768492008806 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 768492008807 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492008808 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 768492008809 Cupin domain; Region: Cupin_2; cl09118 768492008810 Pirin-related protein [General function prediction only]; Region: COG1741 768492008811 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 768492008812 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 768492008813 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768492008814 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 768492008815 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 768492008816 trimer interface [polypeptide binding]; other site 768492008817 eyelet of channel; other site 768492008818 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 768492008819 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 768492008820 putative active site [active] 768492008821 Zn binding site [ion binding]; other site 768492008822 Succinylarginine dihydrolase; Region: AstB; cl01511 768492008823 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 768492008824 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 768492008825 NAD(P) binding site [chemical binding]; other site 768492008826 catalytic residues [active] 768492008827 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 768492008828 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 768492008829 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768492008830 inhibitor-cofactor binding pocket; inhibition site 768492008831 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492008832 catalytic residue [active] 768492008833 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 768492008834 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 768492008835 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 768492008836 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 768492008837 Walker A/P-loop; other site 768492008838 ATP binding site [chemical binding]; other site 768492008839 Q-loop/lid; other site 768492008840 ABC transporter signature motif; other site 768492008841 Walker B; other site 768492008842 D-loop; other site 768492008843 H-loop/switch region; other site 768492008844 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768492008845 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 768492008846 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 768492008847 Walker A/P-loop; other site 768492008848 ATP binding site [chemical binding]; other site 768492008849 Q-loop/lid; other site 768492008850 ABC transporter signature motif; other site 768492008851 Walker B; other site 768492008852 D-loop; other site 768492008853 H-loop/switch region; other site 768492008854 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768492008855 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 768492008856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492008857 dimer interface [polypeptide binding]; other site 768492008858 conserved gate region; other site 768492008859 putative PBP binding loops; other site 768492008860 ABC-ATPase subunit interface; other site 768492008861 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 768492008862 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492008863 dimer interface [polypeptide binding]; other site 768492008864 conserved gate region; other site 768492008865 putative PBP binding loops; other site 768492008866 ABC-ATPase subunit interface; other site 768492008867 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 768492008868 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 768492008869 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768492008870 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492008871 DNA-binding site [nucleotide binding]; DNA binding site 768492008872 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492008873 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492008874 homodimer interface [polypeptide binding]; other site 768492008875 catalytic residue [active] 768492008876 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 768492008877 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 768492008878 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 768492008879 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 768492008880 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 768492008881 Fatty acid desaturase; Region: FA_desaturase; pfam00487 768492008882 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 768492008883 putative di-iron ligands [ion binding]; other site 768492008884 Fatty acid desaturase; Region: FA_desaturase; pfam00487 768492008885 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 768492008886 putative di-iron ligands [ion binding]; other site 768492008887 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 768492008888 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 768492008889 active site 768492008890 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 768492008891 AMP-binding enzyme; Region: AMP-binding; cl15778 768492008892 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 768492008893 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768492008894 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492008895 NAD(P) binding site [chemical binding]; other site 768492008896 active site 768492008897 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 768492008898 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 768492008899 dimer interface [polypeptide binding]; other site 768492008900 active site 768492008901 CoA binding pocket [chemical binding]; other site 768492008902 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 768492008903 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 768492008904 nitrate reductase, beta subunit; Region: narH; TIGR01660 768492008905 4Fe-4S binding domain; Region: Fer4; cl02805 768492008906 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 768492008907 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 768492008908 [4Fe-4S] binding site [ion binding]; other site 768492008909 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 768492008910 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 768492008911 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 768492008912 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 768492008913 molybdopterin cofactor binding site; other site 768492008914 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 768492008915 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 768492008916 active site 768492008917 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 768492008918 active site 768492008919 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 768492008920 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 768492008921 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 768492008922 active site 768492008923 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 768492008924 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 768492008925 putative ADP-binding pocket [chemical binding]; other site 768492008926 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 768492008927 active site 768492008928 ATP-grasp domain; Region: ATP-grasp_4; cl03087 768492008929 MatE; Region: MatE; cl10513 768492008930 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 768492008931 tyrosine kinase; Provisional; Region: PRK11519 768492008932 Chain length determinant protein; Region: Wzz; cl15801 768492008933 Chain length determinant protein; Region: Wzz; cl15801 768492008934 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 768492008935 P loop; other site 768492008936 Nucleotide binding site [chemical binding]; other site 768492008937 DTAP/Switch II; other site 768492008938 Switch I; other site 768492008939 polysaccharide export protein Wza; Provisional; Region: PRK15078 768492008940 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 768492008941 SLBB domain; Region: SLBB; pfam10531 768492008942 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 768492008943 Mg++ binding site [ion binding]; other site 768492008944 putative catalytic motif [active] 768492008945 substrate binding site [chemical binding]; other site 768492008946 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492008947 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 768492008948 NAD(P) binding site [chemical binding]; other site 768492008949 active site 768492008950 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768492008951 DNA binding site [nucleotide binding] 768492008952 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 768492008953 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 768492008954 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 768492008955 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 768492008956 Histidine kinase; Region: HisKA_3; pfam07730 768492008957 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492008958 ATP binding site [chemical binding]; other site 768492008959 Mg2+ binding site [ion binding]; other site 768492008960 G-X-G motif; other site 768492008961 transcriptional regulator NarL; Provisional; Region: PRK10651 768492008962 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492008963 active site 768492008964 phosphorylation site [posttranslational modification] 768492008965 intermolecular recognition site; other site 768492008966 dimerization interface [polypeptide binding]; other site 768492008967 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492008968 DNA binding residues [nucleotide binding] 768492008969 dimerization interface [polypeptide binding]; other site 768492008970 putative invasin; Provisional; Region: PRK10177 768492008971 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 768492008972 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 768492008973 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 768492008974 substrate binding site [chemical binding]; other site 768492008975 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 768492008976 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 768492008977 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 768492008978 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 768492008979 [4Fe-4S] binding site [ion binding]; other site 768492008980 molybdopterin cofactor binding site; other site 768492008981 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 768492008982 molybdopterin cofactor binding site; other site 768492008983 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 768492008984 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 768492008985 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768492008986 nitrite reductase subunit NirD; Provisional; Region: PRK14989 768492008987 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768492008988 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 768492008989 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 768492008990 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 768492008991 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 768492008992 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 768492008993 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 768492008994 Walker A/P-loop; other site 768492008995 ATP binding site [chemical binding]; other site 768492008996 Q-loop/lid; other site 768492008997 ABC transporter signature motif; other site 768492008998 Walker B; other site 768492008999 D-loop; other site 768492009000 H-loop/switch region; other site 768492009001 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492009002 dimer interface [polypeptide binding]; other site 768492009003 conserved gate region; other site 768492009004 putative PBP binding loops; other site 768492009005 ABC-ATPase subunit interface; other site 768492009006 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 768492009007 NMT1-like family; Region: NMT1_2; cl15260 768492009008 Nitrate and nitrite sensing; Region: NIT; pfam08376 768492009009 ANTAR domain; Region: ANTAR; cl04297 768492009010 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 768492009011 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 768492009012 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 768492009013 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768492009014 Walker A/P-loop; other site 768492009015 ATP binding site [chemical binding]; other site 768492009016 Q-loop/lid; other site 768492009017 ABC transporter signature motif; other site 768492009018 Walker B; other site 768492009019 D-loop; other site 768492009020 H-loop/switch region; other site 768492009021 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 768492009022 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 768492009023 Walker A/P-loop; other site 768492009024 ATP binding site [chemical binding]; other site 768492009025 Q-loop/lid; other site 768492009026 ABC transporter signature motif; other site 768492009027 Walker B; other site 768492009028 D-loop; other site 768492009029 H-loop/switch region; other site 768492009030 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 768492009031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492009032 dimer interface [polypeptide binding]; other site 768492009033 conserved gate region; other site 768492009034 putative PBP binding loops; other site 768492009035 ABC-ATPase subunit interface; other site 768492009036 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 768492009037 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492009038 dimer interface [polypeptide binding]; other site 768492009039 conserved gate region; other site 768492009040 putative PBP binding loops; other site 768492009041 ABC-ATPase subunit interface; other site 768492009042 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 768492009043 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 768492009044 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 768492009045 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 768492009046 substrate binding site [chemical binding]; other site 768492009047 dimerization interface [polypeptide binding]; other site 768492009048 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 768492009049 putative active site pocket [active] 768492009050 dimerization interface [polypeptide binding]; other site 768492009051 putative catalytic residue [active] 768492009052 ChaB; Region: ChaB; cl01887 768492009053 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 768492009054 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 768492009055 FAD binding pocket [chemical binding]; other site 768492009056 FAD binding motif [chemical binding]; other site 768492009057 phosphate binding motif [ion binding]; other site 768492009058 NAD binding pocket [chemical binding]; other site 768492009059 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 768492009060 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 768492009061 Cupin domain; Region: Cupin_2; cl09118 768492009062 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492009063 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 768492009064 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768492009065 N-terminal plug; other site 768492009066 ligand-binding site [chemical binding]; other site 768492009067 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 768492009068 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 768492009069 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 768492009070 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 768492009071 Imelysin; Region: Peptidase_M75; cl09159 768492009072 Iron permease FTR1 family; Region: FTR1; cl00475 768492009073 Sodium:solute symporter family; Region: SSF; cl00456 768492009074 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 768492009075 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 768492009076 Proline dehydrogenase; Region: Pro_dh; cl03282 768492009077 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 768492009078 Glutamate binding site [chemical binding]; other site 768492009079 NAD binding site [chemical binding]; other site 768492009080 catalytic residues [active] 768492009081 YcfA-like protein; Region: YcfA; cl00752 768492009082 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 768492009083 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 768492009084 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 768492009085 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 768492009086 Walker A/P-loop; other site 768492009087 ATP binding site [chemical binding]; other site 768492009088 Q-loop/lid; other site 768492009089 ABC transporter signature motif; other site 768492009090 Walker B; other site 768492009091 D-loop; other site 768492009092 H-loop/switch region; other site 768492009093 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492009094 dimer interface [polypeptide binding]; other site 768492009095 conserved gate region; other site 768492009096 putative PBP binding loops; other site 768492009097 ABC-ATPase subunit interface; other site 768492009098 cystine transporter subunit; Provisional; Region: PRK11260 768492009099 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492009100 substrate binding pocket [chemical binding]; other site 768492009101 membrane-bound complex binding site; other site 768492009102 hinge residues; other site 768492009103 D-cysteine desulfhydrase; Validated; Region: PRK03910 768492009104 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 768492009105 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492009106 catalytic residue [active] 768492009107 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 768492009108 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 768492009109 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768492009110 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 768492009111 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768492009112 DNA binding residues [nucleotide binding] 768492009113 flagellin; Validated; Region: PRK06819 768492009114 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 768492009115 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 768492009116 flagellar capping protein; Reviewed; Region: fliD; PRK08032 768492009117 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 768492009118 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 768492009119 Flagellar protein FliS; Region: FliS; cl00654 768492009120 Flagellar protein FliT; Region: FliT; cl05125 768492009121 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768492009122 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492009123 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 768492009124 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 768492009125 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 768492009126 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 768492009127 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 768492009128 FliG C-terminal domain; Region: FliG_C; pfam01706 768492009129 flagellar assembly protein H; Validated; Region: fliH; PRK05687 768492009130 Flagellar assembly protein FliH; Region: FliH; pfam02108 768492009131 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 768492009132 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 768492009133 Walker A motif/ATP binding site; other site 768492009134 Walker B motif; other site 768492009135 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 768492009136 flagellar biosynthesis chaperone; Validated; Region: fliJ; cl09161 768492009137 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 768492009138 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 768492009139 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 768492009140 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 768492009141 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 768492009142 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 768492009143 FliP family; Region: FliP; cl00593 768492009144 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 768492009145 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 768492009146 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 768492009147 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 768492009148 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 768492009149 Flagella basal body rod protein; Region: Flg_bb_rod; cl16924 768492009150 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 768492009151 Rod binding protein; Region: Rod-binding; cl01626 768492009152 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 768492009153 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 768492009154 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 768492009155 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 768492009156 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 768492009157 Flagellar L-ring protein; Region: FlgH; cl00905 768492009158 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 768492009159 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 768492009160 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 768492009161 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 768492009162 Flagella basal body rod protein; Region: Flg_bb_rod; cl16924 768492009163 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 768492009164 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 768492009165 Flagella basal body rod protein; Region: Flg_bb_rod; cl16924 768492009166 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 768492009167 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 768492009168 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 768492009169 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 768492009170 FlgD Ig-like domain; Region: FlgD_ig; cl15790 768492009171 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 768492009172 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 768492009173 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 768492009174 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 768492009175 Flagella basal body rod protein; Region: Flg_bb_rod; cl16924 768492009176 SAF domain; Region: SAF; cl00555 768492009177 SAF-like; Region: SAF_2; pfam13144 768492009178 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 768492009179 FlgN protein; Region: FlgN; cl09176 768492009180 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 768492009181 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 768492009182 Predicted transcriptional regulator [Transcription]; Region: COG2944 768492009183 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 768492009184 Flagellar protein FlhE; Region: FlhE; pfam06366 768492009185 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 768492009186 FHIPEP family; Region: FHIPEP; pfam00771 768492009187 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK12468 768492009188 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 768492009189 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 768492009190 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 768492009191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492009192 active site 768492009193 phosphorylation site [posttranslational modification] 768492009194 intermolecular recognition site; other site 768492009195 dimerization interface [polypeptide binding]; other site 768492009196 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 768492009197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492009198 active site 768492009199 phosphorylation site [posttranslational modification] 768492009200 intermolecular recognition site; other site 768492009201 dimerization interface [polypeptide binding]; other site 768492009202 CheB methylesterase; Region: CheB_methylest; pfam01339 768492009203 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 768492009204 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 768492009205 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 768492009206 methyl-accepting protein IV; Provisional; Region: PRK09793 768492009207 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 768492009208 dimer interface [polypeptide binding]; other site 768492009209 ligand binding site [chemical binding]; other site 768492009210 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768492009211 dimerization interface [polypeptide binding]; other site 768492009212 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768492009213 dimer interface [polypeptide binding]; other site 768492009214 putative CheW interface [polypeptide binding]; other site 768492009215 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 768492009216 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 768492009217 dimer interface [polypeptide binding]; other site 768492009218 ligand binding site [chemical binding]; other site 768492009219 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768492009220 dimerization interface [polypeptide binding]; other site 768492009221 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768492009222 dimer interface [polypeptide binding]; other site 768492009223 putative CheW interface [polypeptide binding]; other site 768492009224 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 768492009225 putative CheA interaction surface; other site 768492009226 chemotaxis protein CheA; Provisional; Region: PRK10547 768492009227 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 768492009228 putative binding surface; other site 768492009229 active site 768492009230 CheY binding; Region: CheY-binding; pfam09078 768492009231 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 768492009232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492009233 ATP binding site [chemical binding]; other site 768492009234 Mg2+ binding site [ion binding]; other site 768492009235 G-X-G motif; other site 768492009236 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 768492009237 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 768492009238 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 768492009239 Flagellar transcriptional activator (FlhC); Region: FlhC; cl05036 768492009240 Flagellar transcriptional activator (FlhD); Region: FlhD; cl05012 768492009241 Haemolysin expression modulating protein; Region: HHA; cl11501 768492009242 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 768492009243 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 768492009244 Prostaglandin dehydrogenases; Region: PGDH; cd05288 768492009245 NAD(P) binding site [chemical binding]; other site 768492009246 substrate binding site [chemical binding]; other site 768492009247 dimer interface [polypeptide binding]; other site 768492009248 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 768492009249 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 768492009250 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 768492009251 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 768492009252 active site 768492009253 DNA binding site [nucleotide binding] 768492009254 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 768492009255 Fungal chitosanase of glycosyl hydrolase group 75; Region: Glyco_hydro_75; pfam07335 768492009256 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 768492009257 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492009258 putative substrate translocation pore; other site 768492009259 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 768492009260 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 768492009261 dimerization domain [polypeptide binding]; other site 768492009262 dimer interface [polypeptide binding]; other site 768492009263 catalytic residues [active] 768492009264 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 768492009265 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 768492009266 Catalytic site [active] 768492009267 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 768492009268 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492009269 active site 768492009270 phosphorylation site [posttranslational modification] 768492009271 intermolecular recognition site; other site 768492009272 dimerization interface [polypeptide binding]; other site 768492009273 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492009274 DNA binding residues [nucleotide binding] 768492009275 dimerization interface [polypeptide binding]; other site 768492009276 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 768492009277 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768492009278 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 768492009279 Transmembrane secretion effector; Region: MFS_3; pfam05977 768492009280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492009281 putative substrate translocation pore; other site 768492009282 DoxX; Region: DoxX; cl00976 768492009283 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 768492009284 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 768492009285 active site 768492009286 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 768492009287 Isochorismatase family; Region: Isochorismatase; pfam00857 768492009288 catalytic triad [active] 768492009289 dimer interface [polypeptide binding]; other site 768492009290 conserved cis-peptide bond; other site 768492009291 Protein of unknown function (DUF1427); Region: DUF1427; cl01771 768492009292 Response regulator receiver domain; Region: Response_reg; pfam00072 768492009293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492009294 active site 768492009295 phosphorylation site [posttranslational modification] 768492009296 intermolecular recognition site; other site 768492009297 dimerization interface [polypeptide binding]; other site 768492009298 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 768492009299 substrate binding site [chemical binding]; other site 768492009300 activation loop (A-loop); other site 768492009301 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492009302 Predicted ATPase [General function prediction only]; Region: COG3899 768492009303 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 768492009304 GAF domain; Region: GAF; cl15785 768492009305 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768492009306 PAS fold; Region: PAS_3; pfam08447 768492009307 putative active site [active] 768492009308 heme pocket [chemical binding]; other site 768492009309 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492009310 dimer interface [polypeptide binding]; other site 768492009311 phosphorylation site [posttranslational modification] 768492009312 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492009313 ATP binding site [chemical binding]; other site 768492009314 Mg2+ binding site [ion binding]; other site 768492009315 G-X-G motif; other site 768492009316 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 768492009317 Helix-turn-helix domains; Region: HTH; cl00088 768492009318 Bacterial transcriptional regulator; Region: IclR; pfam01614 768492009319 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 768492009320 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 768492009321 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 768492009322 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 768492009323 dimer interface [polypeptide binding]; other site 768492009324 active site 768492009325 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 768492009326 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 768492009327 ArsC family; Region: ArsC; pfam03960 768492009328 catalytic residues [active] 768492009329 arsenical pump membrane protein; Provisional; Region: PRK15445 768492009330 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 768492009331 transmembrane helices; other site 768492009332 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768492009333 dimerization interface [polypeptide binding]; other site 768492009334 putative DNA binding site [nucleotide binding]; other site 768492009335 putative Zn2+ binding site [ion binding]; other site 768492009336 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 768492009337 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 768492009338 Helix-turn-helix domains; Region: HTH; cl00088 768492009339 LysR family transcriptional regulator; Provisional; Region: PRK14997 768492009340 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492009341 putative effector binding pocket; other site 768492009342 dimerization interface [polypeptide binding]; other site 768492009343 Protein of unknown function, DUF606; Region: DUF606; cl01273 768492009344 Protein of unknown function, DUF606; Region: DUF606; cl01273 768492009345 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 768492009346 magnesium-transporting ATPase; Provisional; Region: PRK15122 768492009347 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 768492009348 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768492009349 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 768492009350 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 768492009351 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 768492009352 magnesium transport protein MgtC; Provisional; Region: PRK15385 768492009353 MgtC family; Region: MgtC; pfam02308 768492009354 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 768492009355 CoA-transferase family III; Region: CoA_transf_3; pfam02515 768492009356 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768492009357 Helix-turn-helix domains; Region: HTH; cl00088 768492009358 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 768492009359 dimerization interface [polypeptide binding]; other site 768492009360 substrate binding pocket [chemical binding]; other site 768492009361 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768492009362 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492009363 catalytic residue [active] 768492009364 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 768492009365 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492009366 DNA binding residues [nucleotide binding] 768492009367 dimerization interface [polypeptide binding]; other site 768492009368 Dextransucrase DSRB; Region: DSRB; cl11680 768492009369 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 768492009370 DNA-binding site [nucleotide binding]; DNA binding site 768492009371 RNA-binding motif; other site 768492009372 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 768492009373 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 768492009374 NAD(P) binding site [chemical binding]; other site 768492009375 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 768492009376 putative catalytic site [active] 768492009377 putative metal binding site [ion binding]; other site 768492009378 putative phosphate binding site [ion binding]; other site 768492009379 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 768492009380 NAD(P) binding site [chemical binding]; other site 768492009381 active site 768492009382 transcriptional regulator; Provisional; Region: PRK10632 768492009383 Helix-turn-helix domains; Region: HTH; cl00088 768492009384 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492009385 putative effector binding pocket; other site 768492009386 dimerization interface [polypeptide binding]; other site 768492009387 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 768492009388 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 768492009389 Helix-turn-helix domains; Region: HTH; cl00088 768492009390 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492009391 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 768492009392 putative effector binding pocket; other site 768492009393 putative dimerization interface [polypeptide binding]; other site 768492009394 short chain dehydrogenase; Provisional; Region: PRK12744 768492009395 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 768492009396 NADP binding site [chemical binding]; other site 768492009397 homodimer interface [polypeptide binding]; other site 768492009398 active site 768492009399 substrate binding site [chemical binding]; other site 768492009400 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 768492009401 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768492009402 dimer interface [polypeptide binding]; other site 768492009403 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768492009404 metal binding site [ion binding]; metal-binding site 768492009405 active site 768492009406 I-site; other site 768492009407 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 768492009408 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 768492009409 substrate binding site [chemical binding]; other site 768492009410 dimer interface [polypeptide binding]; other site 768492009411 NADP binding site [chemical binding]; other site 768492009412 catalytic residues [active] 768492009413 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 768492009414 substrate binding site [chemical binding]; other site 768492009415 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 768492009416 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 768492009417 Phenylacetic acid degradation B; Region: PaaB; cl01371 768492009418 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 768492009419 Domain of unknown function DUF59; Region: DUF59; cl00941 768492009420 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 768492009421 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 768492009422 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 768492009423 FAD binding pocket [chemical binding]; other site 768492009424 FAD binding motif [chemical binding]; other site 768492009425 phosphate binding motif [ion binding]; other site 768492009426 beta-alpha-beta structure motif; other site 768492009427 NAD(p) ribose binding residues [chemical binding]; other site 768492009428 NAD binding pocket [chemical binding]; other site 768492009429 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 768492009430 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768492009431 catalytic loop [active] 768492009432 iron binding site [ion binding]; other site 768492009433 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 768492009434 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768492009435 substrate binding site [chemical binding]; other site 768492009436 oxyanion hole (OAH) forming residues; other site 768492009437 trimer interface [polypeptide binding]; other site 768492009438 enoyl-CoA hydratase; Provisional; Region: PRK08140 768492009439 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768492009440 substrate binding site [chemical binding]; other site 768492009441 oxyanion hole (OAH) forming residues; other site 768492009442 trimer interface [polypeptide binding]; other site 768492009443 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 768492009444 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492009445 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768492009446 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768492009447 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 768492009448 CoenzymeA binding site [chemical binding]; other site 768492009449 subunit interaction site [polypeptide binding]; other site 768492009450 PHB binding site; other site 768492009451 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 768492009452 AMP-binding enzyme; Region: AMP-binding; cl15778 768492009453 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 768492009454 PaaX-like protein; Region: PaaX; pfam07848 768492009455 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 768492009456 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 768492009457 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 768492009458 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 768492009459 putative trimer interface [polypeptide binding]; other site 768492009460 putative metal binding site [ion binding]; other site 768492009461 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768492009462 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492009463 DNA-binding site [nucleotide binding]; DNA binding site 768492009464 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492009465 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492009466 homodimer interface [polypeptide binding]; other site 768492009467 catalytic residue [active] 768492009468 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 768492009469 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 768492009470 conserved cys residue [active] 768492009471 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492009472 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 768492009473 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 768492009474 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 768492009475 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492009476 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492009477 homodimer interface [polypeptide binding]; other site 768492009478 catalytic residue [active] 768492009479 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 768492009480 homotrimer interaction site [polypeptide binding]; other site 768492009481 putative active site [active] 768492009482 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 768492009483 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 768492009484 LysR family transcriptional regulator; Provisional; Region: PRK14997 768492009485 Helix-turn-helix domains; Region: HTH; cl00088 768492009486 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 768492009487 putative effector binding pocket; other site 768492009488 putative dimerization interface [polypeptide binding]; other site 768492009489 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 768492009490 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 768492009491 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 768492009492 putative N-terminal domain interface [polypeptide binding]; other site 768492009493 putative dimer interface [polypeptide binding]; other site 768492009494 putative substrate binding pocket (H-site) [chemical binding]; other site 768492009495 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 768492009496 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 768492009497 Glycogen synthesis protein; Region: GlgS; cl11663 768492009498 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 768492009499 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 768492009500 tetramerization interface [polypeptide binding]; other site 768492009501 NAD(P) binding site [chemical binding]; other site 768492009502 catalytic residues [active] 768492009503 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 768492009504 dimer interface [polypeptide binding]; other site 768492009505 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768492009506 ligand binding site [chemical binding]; other site 768492009507 Cupin domain; Region: Cupin_2; cl09118 768492009508 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492009509 Helix-turn-helix domains; Region: HTH; cl00088 768492009510 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 768492009511 putative effector binding pocket; other site 768492009512 putative dimerization interface [polypeptide binding]; other site 768492009513 peptide synthase; Provisional; Region: PRK12467 768492009514 AMP-binding enzyme; Region: AMP-binding; cl15778 768492009515 Phosphopantetheine attachment site; Region: PP-binding; cl09936 768492009516 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 768492009517 AMP-binding enzyme; Region: AMP-binding; cl15778 768492009518 Phosphopantetheine attachment site; Region: PP-binding; cl09936 768492009519 peptide synthase; Provisional; Region: PRK12467 768492009520 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 768492009521 AMP-binding enzyme; Region: AMP-binding; cl15778 768492009522 Phosphopantetheine attachment site; Region: PP-binding; cl09936 768492009523 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 768492009524 Uncharacterized membrane protein (DUF2298); Region: DUF2298; cl02250 768492009525 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 768492009526 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 768492009527 Trp docking motif [polypeptide binding]; other site 768492009528 putative active site [active] 768492009529 galactoside permease; Reviewed; Region: lacY; PRK09528 768492009530 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492009531 putative substrate translocation pore; other site 768492009532 alpha-galactosidase; Provisional; Region: PRK15076 768492009533 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 768492009534 NAD binding site [chemical binding]; other site 768492009535 sugar binding site [chemical binding]; other site 768492009536 divalent metal binding site [ion binding]; other site 768492009537 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 768492009538 dimer interface [polypeptide binding]; other site 768492009539 Cupin domain; Region: Cupin_2; cl09118 768492009540 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768492009541 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492009542 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492009543 MATE family multidrug exporter; Provisional; Region: PRK10189 768492009544 MatE; Region: MatE; cl10513 768492009545 MatE; Region: MatE; cl10513 768492009546 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 768492009547 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 768492009548 ligand binding site [chemical binding]; other site 768492009549 flexible hinge region; other site 768492009550 Helix-turn-helix domains; Region: HTH; cl00088 768492009551 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 768492009552 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 768492009553 ligand binding site [chemical binding]; other site 768492009554 flexible hinge region; other site 768492009555 Helix-turn-helix domains; Region: HTH; cl00088 768492009556 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 768492009557 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 768492009558 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 768492009559 putative NAD(P) binding site [chemical binding]; other site 768492009560 short chain dehydrogenase; Provisional; Region: PRK06179 768492009561 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 768492009562 NADP binding site [chemical binding]; other site 768492009563 active site 768492009564 steroid binding site; other site 768492009565 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 768492009566 classical (c) SDRs; Region: SDR_c; cd05233 768492009567 NAD(P) binding site [chemical binding]; other site 768492009568 active site 768492009569 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 768492009570 FMN binding site [chemical binding]; other site 768492009571 active site 768492009572 substrate binding site [chemical binding]; other site 768492009573 catalytic residue [active] 768492009574 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492009575 Helix-turn-helix domains; Region: HTH; cl00088 768492009576 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768492009577 metal binding site [ion binding]; metal-binding site 768492009578 active site 768492009579 I-site; other site 768492009580 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 768492009581 active site 768492009582 MltA-interacting protein MipA; Region: MipA; cl01504 768492009583 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 768492009584 Uncharacterized conserved protein [Function unknown]; Region: COG5361 768492009585 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 768492009586 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 768492009587 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 768492009588 putative NAD(P) binding site [chemical binding]; other site 768492009589 catalytic Zn binding site [ion binding]; other site 768492009590 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 768492009591 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 768492009592 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492009593 Walker A motif; other site 768492009594 ATP binding site [chemical binding]; other site 768492009595 Walker B motif; other site 768492009596 arginine finger; other site 768492009597 Helix-turn-helix domains; Region: HTH; cl00088 768492009598 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768492009599 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492009600 DNA binding site [nucleotide binding] 768492009601 domain linker motif; other site 768492009602 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 768492009603 putative dimerization interface [polypeptide binding]; other site 768492009604 putative ligand binding site [chemical binding]; other site 768492009605 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492009606 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 768492009607 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 768492009608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492009609 dimer interface [polypeptide binding]; other site 768492009610 conserved gate region; other site 768492009611 putative PBP binding loops; other site 768492009612 ABC-ATPase subunit interface; other site 768492009613 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492009614 dimer interface [polypeptide binding]; other site 768492009615 conserved gate region; other site 768492009616 putative PBP binding loops; other site 768492009617 ABC-ATPase subunit interface; other site 768492009618 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 768492009619 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492009620 Walker A/P-loop; other site 768492009621 ATP binding site [chemical binding]; other site 768492009622 Q-loop/lid; other site 768492009623 ABC transporter signature motif; other site 768492009624 Walker B; other site 768492009625 D-loop; other site 768492009626 H-loop/switch region; other site 768492009627 TOBE domain; Region: TOBE_2; cl01440 768492009628 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 768492009629 active site 768492009630 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 768492009631 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492009632 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 768492009633 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 768492009634 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 768492009635 conserved cys residue [active] 768492009636 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492009637 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492009638 short chain dehydrogenase; Provisional; Region: PRK06197 768492009639 NAD(P) binding site [chemical binding]; other site 768492009640 active site 768492009641 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 768492009642 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 768492009643 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 768492009644 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 768492009645 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 768492009646 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 768492009647 Walker A/P-loop; other site 768492009648 ATP binding site [chemical binding]; other site 768492009649 Q-loop/lid; other site 768492009650 ABC transporter signature motif; other site 768492009651 Walker B; other site 768492009652 D-loop; other site 768492009653 H-loop/switch region; other site 768492009654 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 768492009655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492009656 dimer interface [polypeptide binding]; other site 768492009657 conserved gate region; other site 768492009658 putative PBP binding loops; other site 768492009659 ABC-ATPase subunit interface; other site 768492009660 NMT1/THI5 like; Region: NMT1; pfam09084 768492009661 NMT1-like family; Region: NMT1_2; cl15260 768492009662 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 768492009663 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492009664 substrate binding pocket [chemical binding]; other site 768492009665 membrane-bound complex binding site; other site 768492009666 hinge residues; other site 768492009667 Sulfatase; Region: Sulfatase; cl10460 768492009668 AMP nucleosidase; Provisional; Region: PRK08292 768492009669 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 768492009670 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 768492009671 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 768492009672 Helix-turn-helix domains; Region: HTH; cl00088 768492009673 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 768492009674 putative dimerization interface [polypeptide binding]; other site 768492009675 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 768492009676 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492009677 NAD(P) binding site [chemical binding]; other site 768492009678 active site 768492009679 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492009680 Helix-turn-helix domains; Region: HTH; cl00088 768492009681 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492009682 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 768492009683 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 768492009684 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 768492009685 TMP-binding site; other site 768492009686 ATP-binding site [chemical binding]; other site 768492009687 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492009688 Helix-turn-helix domains; Region: HTH; cl00088 768492009689 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 768492009690 putative effector binding pocket; other site 768492009691 putative dimerization interface [polypeptide binding]; other site 768492009692 MFS transport protein AraJ; Provisional; Region: PRK10091 768492009693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492009694 putative substrate translocation pore; other site 768492009695 Helix-turn-helix domains; Region: HTH; cl00088 768492009696 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492009697 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 768492009698 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768492009699 putative NAD(P) binding site [chemical binding]; other site 768492009700 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 768492009701 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492009702 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492009703 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 768492009704 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768492009705 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492009706 catalytic residue [active] 768492009707 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 768492009708 ATP-grasp domain; Region: ATP-grasp_4; cl03087 768492009709 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 768492009710 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 768492009711 active site residue [active] 768492009712 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 768492009713 active site residue [active] 768492009714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492009715 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768492009716 putative substrate translocation pore; other site 768492009717 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 768492009718 Helix-turn-helix domains; Region: HTH; cl00088 768492009719 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 768492009720 LysE type translocator; Region: LysE; cl00565 768492009721 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 768492009722 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492009723 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 768492009724 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 768492009725 methionine synthase; Provisional; Region: PRK01207 768492009726 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 768492009727 substrate binding site [chemical binding]; other site 768492009728 THF binding site; other site 768492009729 zinc-binding site [ion binding]; other site 768492009730 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 768492009731 substrate binding site [chemical binding]; other site 768492009732 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768492009733 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492009734 citrate-proton symporter; Provisional; Region: PRK15075 768492009735 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492009736 putative substrate translocation pore; other site 768492009737 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 768492009738 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492009739 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492009740 Helix-turn-helix domains; Region: HTH; cl00088 768492009741 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 768492009742 putative dimerization interface [polypeptide binding]; other site 768492009743 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 768492009744 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 768492009745 intersubunit interface [polypeptide binding]; other site 768492009746 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492009747 Helix-turn-helix domains; Region: HTH; cl00088 768492009748 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 768492009749 putative effector binding pocket; other site 768492009750 putative dimerization interface [polypeptide binding]; other site 768492009751 Restriction endonuclease; Region: Mrr_cat; cl00516 768492009752 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 768492009753 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768492009754 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768492009755 putative active site [active] 768492009756 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 768492009757 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768492009758 N-terminal plug; other site 768492009759 ligand-binding site [chemical binding]; other site 768492009760 galactoside permease; Reviewed; Region: lacY; PRK09528 768492009761 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492009762 putative substrate translocation pore; other site 768492009763 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 768492009764 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 768492009765 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 768492009766 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 768492009767 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 768492009768 lac repressor; Reviewed; Region: lacI; PRK09526 768492009769 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492009770 DNA binding site [nucleotide binding] 768492009771 domain linker motif; other site 768492009772 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 768492009773 ligand binding site [chemical binding]; other site 768492009774 dimerization interface (open form) [polypeptide binding]; other site 768492009775 dimerization interface (closed form) [polypeptide binding]; other site 768492009776 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768492009777 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 768492009778 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492009779 dimer interface [polypeptide binding]; other site 768492009780 phosphorylation site [posttranslational modification] 768492009781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492009782 ATP binding site [chemical binding]; other site 768492009783 Mg2+ binding site [ion binding]; other site 768492009784 G-X-G motif; other site 768492009785 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 768492009786 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492009787 DNA binding residues [nucleotide binding] 768492009788 dimerization interface [polypeptide binding]; other site 768492009789 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768492009790 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492009791 active site 768492009792 phosphorylation site [posttranslational modification] 768492009793 intermolecular recognition site; other site 768492009794 dimerization interface [polypeptide binding]; other site 768492009795 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768492009796 DNA binding site [nucleotide binding] 768492009797 Protein of unknown function, DUF606; Region: DUF606; cl01273 768492009798 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 768492009799 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 768492009800 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492009801 sequence-specific DNA binding site [nucleotide binding]; other site 768492009802 salt bridge; other site 768492009803 Cupin domain; Region: Cupin_2; cl09118 768492009804 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 768492009805 putative FMN binding site [chemical binding]; other site 768492009806 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768492009807 Helix-turn-helix domains; Region: HTH; cl00088 768492009808 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492009809 dimerization interface [polypeptide binding]; other site 768492009810 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 768492009811 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 768492009812 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 768492009813 putative active site [active] 768492009814 O-Antigen ligase; Region: Wzy_C; cl04850 768492009815 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 768492009816 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 768492009817 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 768492009818 active site 768492009819 dimer interface [polypeptide binding]; other site 768492009820 non-prolyl cis peptide bond; other site 768492009821 insertion regions; other site 768492009822 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 768492009823 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492009824 Walker A motif; other site 768492009825 ATP binding site [chemical binding]; other site 768492009826 Walker B motif; other site 768492009827 arginine finger; other site 768492009828 Helix-turn-helix domains; Region: HTH; cl00088 768492009829 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 768492009830 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492009831 substrate binding pocket [chemical binding]; other site 768492009832 membrane-bound complex binding site; other site 768492009833 hinge residues; other site 768492009834 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 768492009835 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 768492009836 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 768492009837 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 768492009838 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 768492009839 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 768492009840 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 768492009841 Walker A/P-loop; other site 768492009842 ATP binding site [chemical binding]; other site 768492009843 Q-loop/lid; other site 768492009844 ABC transporter signature motif; other site 768492009845 Walker B; other site 768492009846 D-loop; other site 768492009847 H-loop/switch region; other site 768492009848 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 768492009849 Walker A/P-loop; other site 768492009850 ATP binding site [chemical binding]; other site 768492009851 Q-loop/lid; other site 768492009852 ABC transporter signature motif; other site 768492009853 Walker B; other site 768492009854 D-loop; other site 768492009855 H-loop/switch region; other site 768492009856 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 768492009857 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492009858 putative PBP binding loops; other site 768492009859 ABC-ATPase subunit interface; other site 768492009860 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 768492009861 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 768492009862 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492009863 dimer interface [polypeptide binding]; other site 768492009864 conserved gate region; other site 768492009865 putative PBP binding loops; other site 768492009866 ABC-ATPase subunit interface; other site 768492009867 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 768492009868 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 768492009869 tRNA synthetases class II (A); Region: tRNA-synt_2c; pfam01411 768492009870 alanine-tRNA ligase; Region: PLN02961 768492009871 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 768492009872 transcriptional regulator; Provisional; Region: PRK10632 768492009873 Helix-turn-helix domains; Region: HTH; cl00088 768492009874 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492009875 putative effector binding pocket; other site 768492009876 dimerization interface [polypeptide binding]; other site 768492009877 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 768492009878 Predicted permeases [General function prediction only]; Region: RarD; COG2962 768492009879 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 768492009880 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 768492009881 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 768492009882 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 768492009883 catalytic core [active] 768492009884 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 768492009885 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 768492009886 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 768492009887 transmembrane helices; other site 768492009888 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 768492009889 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498 768492009890 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 768492009891 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 768492009892 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 768492009893 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 768492009894 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 768492009895 putative active site [active] 768492009896 (T/H)XGH motif; other site 768492009897 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 768492009898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492009899 active site 768492009900 phosphorylation site [posttranslational modification] 768492009901 intermolecular recognition site; other site 768492009902 dimerization interface [polypeptide binding]; other site 768492009903 Transcriptional regulator; Region: CitT; pfam12431 768492009904 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 768492009905 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824 768492009906 putative hydrophobic ligand binding site [chemical binding]; other site 768492009907 acetoin reductases; Region: 23BDH; TIGR02415 768492009908 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492009909 NAD(P) binding site [chemical binding]; other site 768492009910 active site 768492009911 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 768492009912 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492009913 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768492009914 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768492009915 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 768492009916 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768492009917 E3 interaction surface; other site 768492009918 lipoyl attachment site [posttranslational modification]; other site 768492009919 dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843 768492009920 e3 binding domain; Region: E3_binding; pfam02817 768492009921 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 768492009922 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 768492009923 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 768492009924 alpha subunit interface [polypeptide binding]; other site 768492009925 TPP binding site [chemical binding]; other site 768492009926 heterodimer interface [polypeptide binding]; other site 768492009927 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768492009928 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 768492009929 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 768492009930 tetramer interface [polypeptide binding]; other site 768492009931 TPP-binding site [chemical binding]; other site 768492009932 heterodimer interface [polypeptide binding]; other site 768492009933 phosphorylation loop region [posttranslational modification] 768492009934 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 768492009935 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492009936 Walker A motif; other site 768492009937 ATP binding site [chemical binding]; other site 768492009938 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492009939 DNA binding residues [nucleotide binding] 768492009940 dimerization interface [polypeptide binding]; other site 768492009941 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 768492009942 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 768492009943 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 768492009944 dimer interface [polypeptide binding]; other site 768492009945 active site 768492009946 heme binding site [chemical binding]; other site 768492009947 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 768492009948 HipA N-terminal domain; Region: Couple_hipA; cl11853 768492009949 HipA-like N-terminal domain; Region: HipA_N; pfam07805 768492009950 HipA-like C-terminal domain; Region: HipA_C; pfam07804 768492009951 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 768492009952 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 768492009953 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768492009954 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492009955 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 768492009956 LysR family transcriptional regulator; Provisional; Region: PRK14997 768492009957 Helix-turn-helix domains; Region: HTH; cl00088 768492009958 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 768492009959 putative effector binding pocket; other site 768492009960 putative dimerization interface [polypeptide binding]; other site 768492009961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492009962 putative substrate translocation pore; other site 768492009963 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 768492009964 putative arabinose transporter; Provisional; Region: PRK03545 768492009965 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492009966 putative substrate translocation pore; other site 768492009967 Cupin domain; Region: Cupin_2; cl09118 768492009968 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 768492009969 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 768492009970 Walker A/P-loop; other site 768492009971 ATP binding site [chemical binding]; other site 768492009972 Q-loop/lid; other site 768492009973 ABC transporter signature motif; other site 768492009974 Walker B; other site 768492009975 D-loop; other site 768492009976 H-loop/switch region; other site 768492009977 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 768492009978 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 768492009979 Walker A/P-loop; other site 768492009980 ATP binding site [chemical binding]; other site 768492009981 Q-loop/lid; other site 768492009982 ABC transporter signature motif; other site 768492009983 Walker B; other site 768492009984 D-loop; other site 768492009985 H-loop/switch region; other site 768492009986 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 768492009987 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 768492009988 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 768492009989 TM-ABC transporter signature motif; other site 768492009990 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 768492009991 TM-ABC transporter signature motif; other site 768492009992 leucine ABC transporter subunit substrate-binding protein LivK; Provisional; Region: PRK15404 768492009993 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 768492009994 dimerization interface [polypeptide binding]; other site 768492009995 ligand binding site [chemical binding]; other site 768492009996 transcriptional regulator; Provisional; Region: PRK10632 768492009997 Helix-turn-helix domains; Region: HTH; cl00088 768492009998 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 768492009999 putative effector binding pocket; other site 768492010000 putative dimerization interface [polypeptide binding]; other site 768492010001 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 768492010002 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768492010003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492010004 putative substrate translocation pore; other site 768492010005 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492010006 Helix-turn-helix domains; Region: HTH; cl00088 768492010007 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492010008 putative effector binding pocket; other site 768492010009 dimerization interface [polypeptide binding]; other site 768492010010 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 768492010011 active sites [active] 768492010012 tetramer interface [polypeptide binding]; other site 768492010013 NMT1-like family; Region: NMT1_2; cl15260 768492010014 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 768492010015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 768492010016 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492010017 dimer interface [polypeptide binding]; other site 768492010018 conserved gate region; other site 768492010019 ABC-ATPase subunit interface; other site 768492010020 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 768492010021 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 768492010022 Walker A/P-loop; other site 768492010023 ATP binding site [chemical binding]; other site 768492010024 Q-loop/lid; other site 768492010025 ABC transporter signature motif; other site 768492010026 Walker B; other site 768492010027 D-loop; other site 768492010028 H-loop/switch region; other site 768492010029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492010030 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768492010031 putative substrate translocation pore; other site 768492010032 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 768492010033 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 768492010034 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 768492010035 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 768492010036 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492010037 Helix-turn-helix domains; Region: HTH; cl00088 768492010038 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 768492010039 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492010040 Helix-turn-helix domains; Region: HTH; cl00088 768492010041 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 768492010042 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492010043 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 768492010044 Helix-turn-helix domains; Region: HTH; cl00088 768492010045 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492010046 dimerization interface [polypeptide binding]; other site 768492010047 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 768492010048 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 768492010049 metal binding site [ion binding]; metal-binding site 768492010050 putative dimer interface [polypeptide binding]; other site 768492010051 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 768492010052 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492010053 substrate binding pocket [chemical binding]; other site 768492010054 membrane-bound complex binding site; other site 768492010055 hinge residues; other site 768492010056 Protein of unknown function (DUF496); Region: DUF496; cl09955 768492010057 Predicted membrane protein [Function unknown]; Region: COG1289 768492010058 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 768492010059 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 768492010060 amidase catalytic site [active] 768492010061 Zn binding residues [ion binding]; other site 768492010062 substrate binding site [chemical binding]; other site 768492010063 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 768492010064 Catalytic site [active] 768492010065 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492010066 NAD(P) binding site [chemical binding]; other site 768492010067 active site 768492010068 DNA polymerase III, theta subunit; Region: DNA_pol3_theta; cl11635 768492010069 exonuclease I; Provisional; Region: sbcB; PRK11779 768492010070 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 768492010071 active site 768492010072 catalytic site [active] 768492010073 substrate binding site [chemical binding]; other site 768492010074 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 768492010075 amino acid transporter; Region: 2A0306; TIGR00909 768492010076 Spore germination protein; Region: Spore_permease; cl15802 768492010077 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 768492010078 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 768492010079 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 768492010080 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492010081 non-specific DNA binding site [nucleotide binding]; other site 768492010082 salt bridge; other site 768492010083 sequence-specific DNA binding site [nucleotide binding]; other site 768492010084 Cupin domain; Region: Cupin_2; cl09118 768492010085 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492010086 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 768492010087 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 768492010088 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 768492010089 Walker A/P-loop; other site 768492010090 ATP binding site [chemical binding]; other site 768492010091 Q-loop/lid; other site 768492010092 ABC transporter signature motif; other site 768492010093 Walker B; other site 768492010094 D-loop; other site 768492010095 H-loop/switch region; other site 768492010096 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 768492010097 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768492010098 TM-ABC transporter signature motif; other site 768492010099 putative outer membrane receptor; Provisional; Region: PRK13513 768492010100 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768492010101 N-terminal plug; other site 768492010102 ligand-binding site [chemical binding]; other site 768492010103 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 768492010104 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768492010105 Walker A/P-loop; other site 768492010106 ATP binding site [chemical binding]; other site 768492010107 Q-loop/lid; other site 768492010108 ABC transporter signature motif; other site 768492010109 Walker B; other site 768492010110 D-loop; other site 768492010111 H-loop/switch region; other site 768492010112 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 768492010113 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 768492010114 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768492010115 ABC-ATPase subunit interface; other site 768492010116 dimer interface [polypeptide binding]; other site 768492010117 putative PBP binding regions; other site 768492010118 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768492010119 metal binding site [ion binding]; metal-binding site 768492010120 active site 768492010121 I-site; other site 768492010122 lysine transporter; Provisional; Region: PRK10836 768492010123 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 768492010124 Helix-turn-helix domains; Region: HTH; cl00088 768492010125 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 768492010126 putative dimerization interface [polypeptide binding]; other site 768492010127 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 768492010128 endonuclease IV; Provisional; Region: PRK01060 768492010129 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 768492010130 AP (apurinic/apyrimidinic) site pocket; other site 768492010131 DNA interaction; other site 768492010132 Metal-binding active site; metal-binding site 768492010133 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 768492010134 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 768492010135 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 768492010136 active site 768492010137 P-loop; other site 768492010138 phosphorylation site [posttranslational modification] 768492010139 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 768492010140 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 768492010141 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 768492010142 putative substrate binding site [chemical binding]; other site 768492010143 putative ATP binding site [chemical binding]; other site 768492010144 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 768492010145 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 768492010146 active site 768492010147 phosphorylation site [posttranslational modification] 768492010148 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 768492010149 dimerization domain swap beta strand [polypeptide binding]; other site 768492010150 regulatory protein interface [polypeptide binding]; other site 768492010151 active site 768492010152 regulatory phosphorylation site [posttranslational modification]; other site 768492010153 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_19; cd04678 768492010154 nudix motif; other site 768492010155 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 768492010156 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 768492010157 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 768492010158 molybdopterin cofactor binding site [chemical binding]; other site 768492010159 substrate binding site [chemical binding]; other site 768492010160 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 768492010161 molybdopterin cofactor binding site; other site 768492010162 sugar efflux transporter B; Provisional; Region: PRK15011 768492010163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492010164 putative substrate translocation pore; other site 768492010165 Flagellin N-methylase; Region: FliB; cl00497 768492010166 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 768492010167 aromatic amino acid transport protein; Region: araaP; TIGR00837 768492010168 elongation factor P; Provisional; Region: PRK04542 768492010169 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 768492010170 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 768492010171 RNA binding site [nucleotide binding]; other site 768492010172 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 768492010173 RNA binding site [nucleotide binding]; other site 768492010174 mannonate dehydratase; Provisional; Region: PRK03906 768492010175 mannonate dehydratase; Region: uxuA; TIGR00695 768492010176 D-mannonate oxidoreductase; Provisional; Region: PRK15037 768492010177 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 768492010178 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 768492010179 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 768492010180 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492010181 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 768492010182 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 768492010183 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 768492010184 NlpC/P60 family; Region: NLPC_P60; cl11438 768492010185 phage resistance protein; Provisional; Region: PRK10551 768492010186 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 768492010187 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768492010188 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 768492010189 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 768492010190 microcin C ABC transporter permease YejB; Provisional; Region: PRK15133 768492010191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492010192 dimer interface [polypeptide binding]; other site 768492010193 conserved gate region; other site 768492010194 putative PBP binding loops; other site 768492010195 ABC-ATPase subunit interface; other site 768492010196 microcin C ABC transporter permease; Provisional; Region: PRK15021 768492010197 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 768492010198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492010199 dimer interface [polypeptide binding]; other site 768492010200 conserved gate region; other site 768492010201 putative PBP binding loops; other site 768492010202 ABC-ATPase subunit interface; other site 768492010203 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 768492010204 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 768492010205 Walker A/P-loop; other site 768492010206 ATP binding site [chemical binding]; other site 768492010207 Q-loop/lid; other site 768492010208 ABC transporter signature motif; other site 768492010209 Walker B; other site 768492010210 D-loop; other site 768492010211 H-loop/switch region; other site 768492010212 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 768492010213 Walker A/P-loop; other site 768492010214 ATP binding site [chemical binding]; other site 768492010215 Q-loop/lid; other site 768492010216 ABC transporter signature motif; other site 768492010217 Walker B; other site 768492010218 D-loop; other site 768492010219 H-loop/switch region; other site 768492010220 YejG-like protein; Region: YejG; cl08201 768492010221 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492010222 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 768492010223 putative substrate translocation pore; other site 768492010224 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 768492010225 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768492010226 RNA binding surface [nucleotide binding]; other site 768492010227 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 768492010228 active site 768492010229 uracil binding [chemical binding]; other site 768492010230 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768492010231 ATP binding site [chemical binding]; other site 768492010232 putative Mg++ binding site [ion binding]; other site 768492010233 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768492010234 nucleotide binding region [chemical binding]; other site 768492010235 ATP-binding site [chemical binding]; other site 768492010236 Double zinc ribbon; Region: DZR; pfam12773 768492010237 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 768492010238 5S rRNA interface [nucleotide binding]; other site 768492010239 CTC domain interface [polypeptide binding]; other site 768492010240 L16 interface [polypeptide binding]; other site 768492010241 Nucleoid-associated protein [General function prediction only]; Region: COG3081 768492010242 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 768492010243 Protein of unknown function (DUF1414); Region: DUF1414; cl01175 768492010244 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 768492010245 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 768492010246 Sulfatase; Region: Sulfatase; cl10460 768492010247 DinI-like family; Region: DinI; cl11630 768492010248 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 768492010249 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 768492010250 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 768492010251 active site 768492010252 oxyanion hole [active] 768492010253 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 768492010254 Phage-related protein, tail component [Function unknown]; Region: COG4733 768492010255 Putative phage tail protein; Region: Phage-tail_3; pfam13550 768492010256 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 768492010257 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 768492010258 Fibronectin type III protein; Region: DUF3672; pfam12421 768492010259 Bacteriophage lambda tail assembly protein I; Region: Lambda_tail_I; cl01945 768492010260 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 768492010261 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 768492010262 MPN+ (JAMM) motif; other site 768492010263 Zinc-binding site [ion binding]; other site 768492010264 NlpC/P60 family; Region: NLPC_P60; cl11438 768492010265 Phage minor tail protein L; Region: Phage_tail_L; cl01908 768492010266 Phage minor tail protein; Region: Phage_min_tail; cl01940 768492010267 Phage-related minor tail protein [Function unknown]; Region: COG5281 768492010268 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 768492010269 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 768492010270 Minor tail protein T; Region: Phage_tail_T; cl05636 768492010271 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; cl06106 768492010272 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 768492010273 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 768492010274 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 768492010275 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; cl05094 768492010276 Uncharacterized conserved protein (DUF2190); Region: DUF2190; cl02289 768492010277 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 768492010278 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 768492010279 oligomer interface [polypeptide binding]; other site 768492010280 active site residues [active] 768492010281 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 768492010282 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 768492010283 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; cl05448 768492010284 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 768492010285 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 768492010286 Protein of unknown function (DUF2560); Region: DUF2560; cl10280 768492010287 DNA polymerase III, theta subunit; Region: DNA_pol3_theta; cl11635 768492010288 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 768492010289 Protein of unknown function (DUF754); Region: DUF754; pfam05449 768492010290 Antitermination protein; Region: Antiterm; pfam03589 768492010291 Antitermination protein; Region: Antiterm; pfam03589 768492010292 Protein of unknown function (DUF968); Region: DUF968; pfam06147 768492010293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 768492010294 cofactor binding site; other site 768492010295 DNA binding site [nucleotide binding] 768492010296 substrate interaction site [chemical binding]; other site 768492010297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 768492010298 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442 768492010299 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 768492010300 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 768492010301 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 768492010302 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 768492010303 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492010304 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 768492010305 non-specific DNA binding site [nucleotide binding]; other site 768492010306 salt bridge; other site 768492010307 sequence-specific DNA binding site [nucleotide binding]; other site 768492010308 tellurite resistance protein terB; Region: terB; cd07176 768492010309 putative metal binding site [ion binding]; other site 768492010310 Uncharacterized conserved protein (DUF2303); Region: DUF2303; cl02338 768492010311 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 768492010312 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 768492010313 DNA-binding interface [nucleotide binding]; DNA binding site 768492010314 Protein of unknown function (DUF551); Region: DUF551; pfam04448 768492010315 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 768492010316 active site 768492010317 catalytic site [active] 768492010318 substrate binding site [chemical binding]; other site 768492010319 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 768492010320 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768492010321 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768492010322 active site 768492010323 DNA binding site [nucleotide binding] 768492010324 Int/Topo IB signature motif; other site 768492010325 Acyltransferase family; Region: Acyl_transf_3; pfam01757 768492010326 OpgC protein; Region: OpgC_C; cl00792 768492010327 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 768492010328 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 768492010329 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 768492010330 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 768492010331 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 768492010332 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 768492010333 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 768492010334 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492010335 Helix-turn-helix domains; Region: HTH; cl00088 768492010336 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768492010337 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 768492010338 putative metal binding site [ion binding]; other site 768492010339 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 768492010340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492010341 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 768492010342 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 768492010343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492010344 ATP binding site [chemical binding]; other site 768492010345 Mg2+ binding site [ion binding]; other site 768492010346 G-X-G motif; other site 768492010347 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 768492010348 putative binding surface; other site 768492010349 active site 768492010350 transcriptional regulator RcsB; Provisional; Region: PRK10840 768492010351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492010352 active site 768492010353 phosphorylation site [posttranslational modification] 768492010354 intermolecular recognition site; other site 768492010355 dimerization interface [polypeptide binding]; other site 768492010356 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492010357 DNA binding residues [nucleotide binding] 768492010358 dimerization interface [polypeptide binding]; other site 768492010359 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 768492010360 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492010361 dimer interface [polypeptide binding]; other site 768492010362 phosphorylation site [posttranslational modification] 768492010363 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492010364 ATP binding site [chemical binding]; other site 768492010365 Mg2+ binding site [ion binding]; other site 768492010366 G-X-G motif; other site 768492010367 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 768492010368 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492010369 active site 768492010370 phosphorylation site [posttranslational modification] 768492010371 intermolecular recognition site; other site 768492010372 dimerization interface [polypeptide binding]; other site 768492010373 DNA gyrase subunit A; Validated; Region: PRK05560 768492010374 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 768492010375 CAP-like domain; other site 768492010376 active site 768492010377 primary dimer interface [polypeptide binding]; other site 768492010378 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768492010379 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768492010380 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768492010381 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768492010382 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768492010383 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768492010384 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 768492010385 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492010386 S-adenosylmethionine binding site [chemical binding]; other site 768492010387 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 768492010388 ATP cone domain; Region: ATP-cone; pfam03477 768492010389 Class I ribonucleotide reductase; Region: RNR_I; cd01679 768492010390 active site 768492010391 dimer interface [polypeptide binding]; other site 768492010392 catalytic residues [active] 768492010393 effector binding site; other site 768492010394 R2 peptide binding site; other site 768492010395 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 768492010396 dimer interface [polypeptide binding]; other site 768492010397 putative radical transfer pathway; other site 768492010398 diiron center [ion binding]; other site 768492010399 tyrosyl radical; other site 768492010400 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768492010401 catalytic loop [active] 768492010402 iron binding site [ion binding]; other site 768492010403 Hok/gef family; Region: HOK_GEF; cl11494 768492010404 hypothetical protein; Provisional; Region: PRK03673 768492010405 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 768492010406 putative MPT binding site; other site 768492010407 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 768492010408 aromatic amino acid transport protein; Region: araaP; TIGR00837 768492010409 YfaZ precursor; Region: YfaZ; pfam07437 768492010410 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 768492010411 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 768492010412 tetramer interface [polypeptide binding]; other site 768492010413 heme binding pocket [chemical binding]; other site 768492010414 NADPH binding site [chemical binding]; other site 768492010415 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 768492010416 AMP-binding enzyme; Region: AMP-binding; cl15778 768492010417 O-succinylbenzoate synthase; Provisional; Region: PRK05105 768492010418 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 768492010419 active site 768492010420 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768492010421 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 768492010422 substrate binding site [chemical binding]; other site 768492010423 oxyanion hole (OAH) forming residues; other site 768492010424 trimer interface [polypeptide binding]; other site 768492010425 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 768492010426 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 768492010427 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 768492010428 dimer interface [polypeptide binding]; other site 768492010429 tetramer interface [polypeptide binding]; other site 768492010430 PYR/PP interface [polypeptide binding]; other site 768492010431 TPP binding site [chemical binding]; other site 768492010432 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 768492010433 TPP-binding site; other site 768492010434 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 768492010435 chorismate binding enzyme; Region: Chorismate_bind; cl10555 768492010436 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 768492010437 Putative glucoamylase; Region: Glycoamylase; pfam10091 768492010438 Putative carbohydrate binding domain; Region: CBM_X; cl05621 768492010439 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 768492010440 Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205 768492010441 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 768492010442 Putative carbohydrate binding domain; Region: CBM_X; cl05621 768492010443 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 768492010444 Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205 768492010445 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 768492010446 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 768492010447 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 768492010448 putative NAD(P) binding site [chemical binding]; other site 768492010449 catalytic Zn binding site [ion binding]; other site 768492010450 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 768492010451 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 768492010452 NADP binding site [chemical binding]; other site 768492010453 homodimer interface [polypeptide binding]; other site 768492010454 active site 768492010455 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 768492010456 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492010457 DNA binding site [nucleotide binding] 768492010458 domain linker motif; other site 768492010459 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 768492010460 putative ligand binding site [chemical binding]; other site 768492010461 putative dimerization interface [polypeptide binding]; other site 768492010462 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 768492010463 Transmembrane secretion effector; Region: MFS_3; pfam05977 768492010464 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 768492010465 Cupin domain; Region: Cupin_2; cl09118 768492010466 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 768492010467 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768492010468 PYR/PP interface [polypeptide binding]; other site 768492010469 dimer interface [polypeptide binding]; other site 768492010470 TPP binding site [chemical binding]; other site 768492010471 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 768492010472 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 768492010473 TPP-binding site [chemical binding]; other site 768492010474 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492010475 Helix-turn-helix domains; Region: HTH; cl00088 768492010476 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492010477 dimerization interface [polypeptide binding]; other site 768492010478 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 768492010479 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 768492010480 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 768492010481 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 768492010482 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 768492010483 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 768492010484 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 768492010485 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 768492010486 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 768492010487 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 768492010488 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 768492010489 4Fe-4S binding domain; Region: Fer4; cl02805 768492010490 4Fe-4S binding domain; Region: Fer4; cl02805 768492010491 NADH dehydrogenase; Region: NADHdh; cl00469 768492010492 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 768492010493 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768492010494 catalytic loop [active] 768492010495 iron binding site [ion binding]; other site 768492010496 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 768492010497 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 768492010498 [4Fe-4S] binding site [ion binding]; other site 768492010499 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 768492010500 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 768492010501 SLBB domain; Region: SLBB; pfam10531 768492010502 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 768492010503 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 768492010504 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 768492010505 putative dimer interface [polypeptide binding]; other site 768492010506 [2Fe-2S] cluster binding site [ion binding]; other site 768492010507 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 768492010508 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 768492010509 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 768492010510 NADH dehydrogenase subunit B; Validated; Region: PRK06411 768492010511 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 768492010512 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 768492010513 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 768492010514 Helix-turn-helix domains; Region: HTH; cl00088 768492010515 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 768492010516 putative dimerization interface [polypeptide binding]; other site 768492010517 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 768492010518 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492010519 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492010520 homodimer interface [polypeptide binding]; other site 768492010521 catalytic residue [active] 768492010522 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 768492010523 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 768492010524 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 768492010525 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 768492010526 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 768492010527 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 768492010528 putative phosphatase; Provisional; Region: PRK11587 768492010529 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 768492010530 YfbU domain; Region: YfbU; cl01137 768492010531 Protein of unknown function, DUF412; Region: DUF412; cl01183 768492010532 acetate kinase; Region: ackA; TIGR00016 768492010533 Acetokinase family; Region: Acetate_kinase; cl01029 768492010534 phosphate acetyltransferase; Reviewed; Region: PRK05632 768492010535 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492010536 DRTGG domain; Region: DRTGG; cl12147 768492010537 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 768492010538 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 768492010539 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 768492010540 nudix motif; other site 768492010541 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 768492010542 active site 768492010543 metal binding site [ion binding]; metal-binding site 768492010544 homotetramer interface [polypeptide binding]; other site 768492010545 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 768492010546 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 768492010547 C-terminal domain interface [polypeptide binding]; other site 768492010548 GSH binding site (G-site) [chemical binding]; other site 768492010549 dimer interface [polypeptide binding]; other site 768492010550 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 768492010551 N-terminal domain interface [polypeptide binding]; other site 768492010552 putative dimer interface [polypeptide binding]; other site 768492010553 active site 768492010554 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 768492010555 homooctamer interface [polypeptide binding]; other site 768492010556 active site 768492010557 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 768492010558 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 768492010559 putative NAD(P) binding site [chemical binding]; other site 768492010560 putative active site [active] 768492010561 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 768492010562 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 768492010563 Walker A/P-loop; other site 768492010564 ATP binding site [chemical binding]; other site 768492010565 Q-loop/lid; other site 768492010566 ABC transporter signature motif; other site 768492010567 Walker B; other site 768492010568 D-loop; other site 768492010569 H-loop/switch region; other site 768492010570 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768492010571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492010572 dimer interface [polypeptide binding]; other site 768492010573 conserved gate region; other site 768492010574 putative PBP binding loops; other site 768492010575 ABC-ATPase subunit interface; other site 768492010576 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768492010577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492010578 dimer interface [polypeptide binding]; other site 768492010579 conserved gate region; other site 768492010580 putative PBP binding loops; other site 768492010581 ABC-ATPase subunit interface; other site 768492010582 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 768492010583 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492010584 substrate binding pocket [chemical binding]; other site 768492010585 membrane-bound complex binding site; other site 768492010586 hinge residues; other site 768492010587 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 768492010588 Flavoprotein; Region: Flavoprotein; cl08021 768492010589 amidophosphoribosyltransferase; Provisional; Region: PRK09246 768492010590 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 768492010591 active site 768492010592 tetramer interface [polypeptide binding]; other site 768492010593 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768492010594 active site 768492010595 Colicin V production protein; Region: Colicin_V; cl00567 768492010596 cell division protein DedD; Provisional; Region: PRK11633 768492010597 Sporulation related domain; Region: SPOR; cl10051 768492010598 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 768492010599 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768492010600 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768492010601 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 768492010602 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 768492010603 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 768492010604 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 768492010605 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 768492010606 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 768492010607 dimerization interface 3.5A [polypeptide binding]; other site 768492010608 active site 768492010609 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 768492010610 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492010611 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 768492010612 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 768492010613 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492010614 Domain of unknown function (DUF3410); Region: DUF3410; pfam11890 768492010615 Cupin domain; Region: Cupin_2; cl09118 768492010616 Helix-turn-helix domain; Region: HTH_18; pfam12833 768492010617 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492010618 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 768492010619 EamA-like transporter family; Region: EamA; cl01037 768492010620 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 768492010621 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768492010622 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 768492010623 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492010624 dimer interface [polypeptide binding]; other site 768492010625 phosphorylation site [posttranslational modification] 768492010626 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492010627 ATP binding site [chemical binding]; other site 768492010628 Mg2+ binding site [ion binding]; other site 768492010629 G-X-G motif; other site 768492010630 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 768492010631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492010632 active site 768492010633 phosphorylation site [posttranslational modification] 768492010634 intermolecular recognition site; other site 768492010635 dimerization interface [polypeptide binding]; other site 768492010636 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768492010637 DNA binding site [nucleotide binding] 768492010638 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 768492010639 NMT1-like family; Region: NMT1_2; cl15260 768492010640 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 768492010641 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 768492010642 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 768492010643 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 768492010644 trimer interface [polypeptide binding]; other site 768492010645 active site 768492010646 CoA binding site [chemical binding]; other site 768492010647 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 768492010648 EamA-like transporter family; Region: EamA; cl01037 768492010649 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768492010650 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492010651 DNA-binding site [nucleotide binding]; DNA binding site 768492010652 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492010653 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492010654 homodimer interface [polypeptide binding]; other site 768492010655 catalytic residue [active] 768492010656 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 768492010657 catalytic residues [active] 768492010658 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 768492010659 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 768492010660 catalytic residues [active] 768492010661 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 768492010662 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 768492010663 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 768492010664 DsbD alpha interface [polypeptide binding]; other site 768492010665 catalytic residues [active] 768492010666 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 768492010667 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 768492010668 active site residue [active] 768492010669 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768492010670 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492010671 DNA-binding site [nucleotide binding]; DNA binding site 768492010672 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492010673 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492010674 homodimer interface [polypeptide binding]; other site 768492010675 catalytic residue [active] 768492010676 putative transporter; Provisional; Region: PRK12382 768492010677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492010678 putative substrate translocation pore; other site 768492010679 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 768492010680 putative catalytic site [active] 768492010681 putative metal binding site [ion binding]; other site 768492010682 putative phosphate binding site [ion binding]; other site 768492010683 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 768492010684 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 768492010685 metal binding site [ion binding]; metal-binding site 768492010686 dimer interface [polypeptide binding]; other site 768492010687 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 768492010688 transmembrane helices; other site 768492010689 ApbE family; Region: ApbE; cl00643 768492010690 peptidyl-prolyl isomerase, gliding motility-associated; Region: ppisom_GldI; TIGR03516 768492010691 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 768492010692 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 768492010693 dimer interface [polypeptide binding]; other site 768492010694 active site 768492010695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 768492010696 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 768492010697 YfcL protein; Region: YfcL; pfam08891 768492010698 Protein of unknown function, DUF462; Region: DUF462; cl01190 768492010699 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 768492010700 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 768492010701 Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538 768492010702 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 768492010703 Tetramer interface [polypeptide binding]; other site 768492010704 active site 768492010705 FMN-binding site [chemical binding]; other site 768492010706 HemK family putative methylases; Region: hemK_fam; TIGR00536 768492010707 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492010708 S-adenosylmethionine binding site [chemical binding]; other site 768492010709 hypothetical protein; Provisional; Region: PRK04946 768492010710 Smr domain; Region: Smr; cl02619 768492010711 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768492010712 catalytic core [active] 768492010713 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 768492010714 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768492010715 substrate binding site [chemical binding]; other site 768492010716 oxyanion hole (OAH) forming residues; other site 768492010717 trimer interface [polypeptide binding]; other site 768492010718 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492010719 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768492010720 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768492010721 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 768492010722 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 768492010723 dimer interface [polypeptide binding]; other site 768492010724 active site 768492010725 Protein of unknown function (DUF406); Region: DUF406; cl11449 768492010726 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 768492010727 VacJ like lipoprotein; Region: VacJ; cl01073 768492010728 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 768492010729 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 768492010730 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768492010731 binding surface 768492010732 TPR motif; other site 768492010733 Cytochrome C biogenesis protein; Region: CcmH; cl01179 768492010734 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 768492010735 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 768492010736 catalytic residues [active] 768492010737 central insert; other site 768492010738 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 768492010739 CcmE; Region: CcmE; cl00994 768492010740 Heme exporter protein D (CcmD); Region: CcmD; cl11475 768492010741 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 768492010742 CcmB protein; Region: CcmB; cl01016 768492010743 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 768492010744 CcmA, the ATP-binding component of the bacterial CcmAB transporter. The CCM family is involved in bacterial cytochrome c biogenesis. Cytochrome c maturation in E. coli requires the ccm operon, which encodes eight membrane proteins (CcmABCDEFGH). CcmE...; Region: ABC_CcmA_heme_exporter; cd03231 768492010745 Walker A/P-loop; other site 768492010746 ATP binding site [chemical binding]; other site 768492010747 Q-loop/lid; other site 768492010748 ABC transporter signature motif; other site 768492010749 Walker B; other site 768492010750 D-loop; other site 768492010751 H-loop/switch region; other site 768492010752 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 768492010753 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 768492010754 Helix-turn-helix domains; Region: HTH; cl00088 768492010755 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 768492010756 dimerization interface [polypeptide binding]; other site 768492010757 substrate binding pocket [chemical binding]; other site 768492010758 EamA-like transporter family; Region: EamA; cl01037 768492010759 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 768492010760 eyelet of channel; other site 768492010761 trimer interface [polypeptide binding]; other site 768492010762 Transglycosylase SLT domain; Region: SLT_2; pfam13406 768492010763 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 768492010764 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768492010765 catalytic residue [active] 768492010766 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 768492010767 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 768492010768 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 768492010769 aminotransferase; Validated; Region: PRK08175 768492010770 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492010771 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492010772 homodimer interface [polypeptide binding]; other site 768492010773 catalytic residue [active] 768492010774 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768492010775 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 768492010776 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 768492010777 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 768492010778 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 768492010779 GAF domain; Region: GAF; cl15785 768492010780 Histidine kinase; Region: His_kinase; pfam06580 768492010781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492010782 ATP binding site [chemical binding]; other site 768492010783 Mg2+ binding site [ion binding]; other site 768492010784 G-X-G motif; other site 768492010785 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 768492010786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492010787 active site 768492010788 phosphorylation site [posttranslational modification] 768492010789 intermolecular recognition site; other site 768492010790 dimerization interface [polypeptide binding]; other site 768492010791 LytTr DNA-binding domain; Region: LytTR; cl04498 768492010792 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 768492010793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492010794 putative substrate translocation pore; other site 768492010795 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 768492010796 glucokinase, proteobacterial type; Region: glk; TIGR00749 768492010797 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 768492010798 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 768492010799 Cl- selectivity filter; other site 768492010800 Cl- binding residues [ion binding]; other site 768492010801 pore gating glutamate residue; other site 768492010802 dimer interface [polypeptide binding]; other site 768492010803 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 768492010804 aspartate racemase; Region: asp_race; TIGR00035 768492010805 Predicted membrane protein [Function unknown]; Region: COG4125 768492010806 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 768492010807 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 768492010808 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492010809 Helix-turn-helix domains; Region: HTH; cl00088 768492010810 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768492010811 dimerization interface [polypeptide binding]; other site 768492010812 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 768492010813 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 768492010814 dimer interface [polypeptide binding]; other site 768492010815 PYR/PP interface [polypeptide binding]; other site 768492010816 TPP binding site [chemical binding]; other site 768492010817 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 768492010818 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 768492010819 TPP-binding site [chemical binding]; other site 768492010820 dimer interface [polypeptide binding]; other site 768492010821 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 768492010822 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768492010823 active site 768492010824 catalytic tetrad [active] 768492010825 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 768492010826 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 768492010827 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 768492010828 nucleoside transporter; Region: nupC; TIGR00804 768492010829 Nucleoside recognition; Region: Gate; cl00486 768492010830 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 768492010831 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 768492010832 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 768492010833 HIGH motif; other site 768492010834 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 768492010835 active site 768492010836 KMSKS motif; other site 768492010837 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 768492010838 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 768492010839 putative NAD(P) binding site [chemical binding]; other site 768492010840 active site 768492010841 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 768492010842 hydrophobic substrate binding pocket; other site 768492010843 Isochorismatase family; Region: Isochorismatase; pfam00857 768492010844 active site 768492010845 conserved cis-peptide bond; other site 768492010846 Phosphopantetheine attachment site; Region: PP-binding; cl09936 768492010847 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 768492010848 AMP-binding enzyme; Region: AMP-binding; cl15778 768492010849 AMP-binding enzyme; Region: AMP-binding; cl15778 768492010850 isochorismate synthase EntC; Provisional; Region: PRK15016 768492010851 chorismate binding enzyme; Region: Chorismate_bind; cl10555 768492010852 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 768492010853 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 768492010854 siderophore binding site; other site 768492010855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492010856 H+ Antiporter protein; Region: 2A0121; TIGR00900 768492010857 putative substrate translocation pore; other site 768492010858 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 768492010859 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768492010860 ABC-ATPase subunit interface; other site 768492010861 dimer interface [polypeptide binding]; other site 768492010862 putative PBP binding regions; other site 768492010863 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 768492010864 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768492010865 ABC-ATPase subunit interface; other site 768492010866 dimer interface [polypeptide binding]; other site 768492010867 putative PBP binding regions; other site 768492010868 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 768492010869 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768492010870 Walker A/P-loop; other site 768492010871 ATP binding site [chemical binding]; other site 768492010872 Q-loop/lid; other site 768492010873 ABC transporter signature motif; other site 768492010874 Walker B; other site 768492010875 D-loop; other site 768492010876 H-loop/switch region; other site 768492010877 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 768492010878 AMP-binding enzyme; Region: AMP-binding; cl15778 768492010879 Phosphopantetheine attachment site; Region: PP-binding; cl09936 768492010880 MbtH-like protein; Region: MbtH; cl01279 768492010881 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 768492010882 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 768492010883 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 768492010884 outer membrane receptor FepA; Provisional; Region: PRK13524 768492010885 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768492010886 N-terminal plug; other site 768492010887 ligand-binding site [chemical binding]; other site 768492010888 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 768492010889 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 768492010890 peptide binding site [polypeptide binding]; other site 768492010891 acetolactate synthase; Reviewed; Region: PRK08617 768492010892 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768492010893 PYR/PP interface [polypeptide binding]; other site 768492010894 dimer interface [polypeptide binding]; other site 768492010895 TPP binding site [chemical binding]; other site 768492010896 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 768492010897 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 768492010898 TPP-binding site [chemical binding]; other site 768492010899 dimer interface [polypeptide binding]; other site 768492010900 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 768492010901 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492010902 Helix-turn-helix domains; Region: HTH; cl00088 768492010903 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492010904 putative effector binding pocket; other site 768492010905 dimerization interface [polypeptide binding]; other site 768492010906 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 768492010907 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 768492010908 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 768492010909 Bacterial protein of unknown function (DUF925); Region: DUF925; cl01435 768492010910 FlxA-like protein; Region: FlxA; pfam14282 768492010911 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492010912 Helix-turn-helix domains; Region: HTH; cl00088 768492010913 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 768492010914 putative dimerization interface [polypeptide binding]; other site 768492010915 Membrane transport protein; Region: Mem_trans; cl09117 768492010916 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 768492010917 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 768492010918 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 768492010919 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 768492010920 nucleotide binding pocket [chemical binding]; other site 768492010921 K-X-D-G motif; other site 768492010922 catalytic site [active] 768492010923 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 768492010924 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 768492010925 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 768492010926 Dimer interface [polypeptide binding]; other site 768492010927 BRCT sequence motif; other site 768492010928 cell division protein ZipA; Provisional; Region: PRK03427 768492010929 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 768492010930 FtsZ protein binding site [polypeptide binding]; other site 768492010931 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 768492010932 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 768492010933 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 768492010934 dimer interface [polypeptide binding]; other site 768492010935 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492010936 catalytic residue [active] 768492010937 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 768492010938 dimerization domain swap beta strand [polypeptide binding]; other site 768492010939 regulatory protein interface [polypeptide binding]; other site 768492010940 active site 768492010941 regulatory phosphorylation site [posttranslational modification]; other site 768492010942 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 768492010943 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 768492010944 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 768492010945 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 768492010946 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 768492010947 HPr interaction site; other site 768492010948 glycerol kinase (GK) interaction site [polypeptide binding]; other site 768492010949 active site 768492010950 phosphorylation site [posttranslational modification] 768492010951 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 768492010952 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768492010953 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768492010954 dimerization interface [polypeptide binding]; other site 768492010955 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492010956 dimer interface [polypeptide binding]; other site 768492010957 phosphorylation site [posttranslational modification] 768492010958 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492010959 ATP binding site [chemical binding]; other site 768492010960 Mg2+ binding site [ion binding]; other site 768492010961 G-X-G motif; other site 768492010962 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768492010963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492010964 active site 768492010965 phosphorylation site [posttranslational modification] 768492010966 intermolecular recognition site; other site 768492010967 dimerization interface [polypeptide binding]; other site 768492010968 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768492010969 DNA binding site [nucleotide binding] 768492010970 macrolide transporter subunit MacA; Provisional; Region: PRK11578 768492010971 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 768492010972 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 768492010973 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 768492010974 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 768492010975 Walker A/P-loop; other site 768492010976 ATP binding site [chemical binding]; other site 768492010977 Q-loop/lid; other site 768492010978 ABC transporter signature motif; other site 768492010979 Walker B; other site 768492010980 D-loop; other site 768492010981 H-loop/switch region; other site 768492010982 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768492010983 FtsX-like permease family; Region: FtsX; cl15850 768492010984 cysteine synthase B; Region: cysM; TIGR01138 768492010985 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 768492010986 dimer interface [polypeptide binding]; other site 768492010987 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492010988 catalytic residue [active] 768492010989 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 768492010990 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296 768492010991 Walker A/P-loop; other site 768492010992 ATP binding site [chemical binding]; other site 768492010993 Q-loop/lid; other site 768492010994 ABC transporter signature motif; other site 768492010995 Walker B; other site 768492010996 D-loop; other site 768492010997 H-loop/switch region; other site 768492010998 TOBE-like domain; Region: TOBE_3; pfam12857 768492010999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492011000 dimer interface [polypeptide binding]; other site 768492011001 conserved gate region; other site 768492011002 putative PBP binding loops; other site 768492011003 ABC-ATPase subunit interface; other site 768492011004 sulfate transport protein; Provisional; Region: cysT; CHL00187 768492011005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492011006 dimer interface [polypeptide binding]; other site 768492011007 conserved gate region; other site 768492011008 putative PBP binding loops; other site 768492011009 ABC-ATPase subunit interface; other site 768492011010 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492011011 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 768492011012 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 768492011013 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 768492011014 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 768492011015 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 768492011016 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 768492011017 putative acetyltransferase; Provisional; Region: PRK03624 768492011018 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492011019 Coenzyme A binding pocket [chemical binding]; other site 768492011020 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 768492011021 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 768492011022 active site 768492011023 metal binding site [ion binding]; metal-binding site 768492011024 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 768492011025 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 768492011026 Protein of unknown function, DUF399; Region: DUF399; cl01139 768492011027 S-methylmethionine transporter; Provisional; Region: PRK11387 768492011028 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 768492011029 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 768492011030 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 768492011031 Malic enzyme, N-terminal domain; Region: malic; pfam00390 768492011032 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 768492011033 putative NAD(P) binding site [chemical binding]; other site 768492011034 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 768492011035 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 768492011036 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 768492011037 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 768492011038 Glyco_18 domain; Region: Glyco_18; smart00636 768492011039 active site 768492011040 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 768492011041 transcriptional regulator, ArgP family; Region: argP; TIGR03298 768492011042 Helix-turn-helix domains; Region: HTH; cl00088 768492011043 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492011044 dimerization interface [polypeptide binding]; other site 768492011045 Chitin binding domain; Region: Chitin_bind_3; cl03871 768492011046 transaldolase-like protein; Provisional; Region: PTZ00411 768492011047 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 768492011048 active site 768492011049 dimer interface [polypeptide binding]; other site 768492011050 catalytic residue [active] 768492011051 transketolase; Reviewed; Region: PRK12753 768492011052 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 768492011053 TPP-binding site [chemical binding]; other site 768492011054 dimer interface [polypeptide binding]; other site 768492011055 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 768492011056 PYR/PP interface [polypeptide binding]; other site 768492011057 dimer interface [polypeptide binding]; other site 768492011058 TPP binding site [chemical binding]; other site 768492011059 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768492011060 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 768492011061 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 768492011062 dimer interface [polypeptide binding]; other site 768492011063 ADP-ribose binding site [chemical binding]; other site 768492011064 active site 768492011065 nudix motif; other site 768492011066 metal binding site [ion binding]; metal-binding site 768492011067 cytochrome c-type protein NapC; Provisional; Region: PRK10617 768492011068 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153 768492011069 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 768492011070 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 768492011071 [4Fe-4S] binding site [ion binding]; other site 768492011072 molybdopterin cofactor binding site; other site 768492011073 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 768492011074 molybdopterin cofactor binding site; other site 768492011075 NapD protein; Region: NapD; cl01163 768492011076 ferredoxin-type protein; Provisional; Region: PRK10194 768492011077 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768492011078 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 768492011079 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 768492011080 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 768492011081 Histidine kinase; Region: HisKA_3; pfam07730 768492011082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492011083 ATP binding site [chemical binding]; other site 768492011084 Mg2+ binding site [ion binding]; other site 768492011085 G-X-G motif; other site 768492011086 transcriptional regulator NarP; Provisional; Region: PRK10403 768492011087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492011088 active site 768492011089 phosphorylation site [posttranslational modification] 768492011090 intermolecular recognition site; other site 768492011091 dimerization interface [polypeptide binding]; other site 768492011092 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492011093 DNA binding residues [nucleotide binding] 768492011094 dimerization interface [polypeptide binding]; other site 768492011095 Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; cl11547 768492011096 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 768492011097 Protein export membrane protein; Region: SecD_SecF; cl14618 768492011098 putative outer membrane receptor; Provisional; Region: PRK13513 768492011099 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768492011100 N-terminal plug; other site 768492011101 ligand-binding site [chemical binding]; other site 768492011102 Uncharacterized conserved protein [Function unknown]; Region: COG3391 768492011103 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 768492011104 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768492011105 N-terminal plug; other site 768492011106 ligand-binding site [chemical binding]; other site 768492011107 Tetratrico peptide repeat; Region: TPR_5; pfam12688 768492011108 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492011109 Coenzyme A binding pocket [chemical binding]; other site 768492011110 Chorismate mutase type II; Region: CM_2; cl00693 768492011111 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 768492011112 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 768492011113 ArsC family; Region: ArsC; pfam03960 768492011114 putative catalytic residues [active] 768492011115 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 768492011116 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 768492011117 metal binding site [ion binding]; metal-binding site 768492011118 dimer interface [polypeptide binding]; other site 768492011119 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 768492011120 Uncharacterized protein family (UPF0370); Region: UPF0370; cl10119 768492011121 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 768492011122 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 768492011123 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 768492011124 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 768492011125 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 768492011126 Uncharacterized conserved protein [Function unknown]; Region: COG2308 768492011127 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174 768492011128 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 768492011129 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 768492011130 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 768492011131 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 768492011132 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 768492011133 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 768492011134 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492011135 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 768492011136 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 768492011137 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 768492011138 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 768492011139 ATP binding site [chemical binding]; other site 768492011140 active site 768492011141 substrate binding site [chemical binding]; other site 768492011142 lipoprotein; Provisional; Region: PRK11679 768492011143 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 768492011144 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 768492011145 dihydrodipicolinate synthase; Region: dapA; TIGR00674 768492011146 dimer interface [polypeptide binding]; other site 768492011147 active site 768492011148 catalytic residue [active] 768492011149 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 768492011150 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 768492011151 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 768492011152 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 768492011153 catalytic triad [active] 768492011154 Domain of unknown function DUF20; Region: UPF0118; pfam01594 768492011155 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 768492011156 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 768492011157 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 768492011158 MoaE homodimer interface [polypeptide binding]; other site 768492011159 MoaD interaction [polypeptide binding]; other site 768492011160 active site residues [active] 768492011161 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 768492011162 MoaE interaction surface [polypeptide binding]; other site 768492011163 MoeB interaction surface [polypeptide binding]; other site 768492011164 thiocarboxylated glycine; other site 768492011165 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 768492011166 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768492011167 FeS/SAM binding site; other site 768492011168 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 768492011169 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 768492011170 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 768492011171 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 768492011172 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 768492011173 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 768492011174 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 768492011175 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 768492011176 putative molybdopterin cofactor binding site [chemical binding]; other site 768492011177 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 768492011178 putative molybdopterin cofactor binding site; other site 768492011179 LysE type translocator; Region: LysE; cl00565 768492011180 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768492011181 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768492011182 putative DNA binding site [nucleotide binding]; other site 768492011183 putative Zn2+ binding site [ion binding]; other site 768492011184 Helix-turn-helix domains; Region: HTH; cl00088 768492011185 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 768492011186 Predicted transcriptional regulator [Transcription]; Region: COG1959 768492011187 Helix-turn-helix domains; Region: HTH; cl00088 768492011188 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 768492011189 Peptidase family M48; Region: Peptidase_M48; cl12018 768492011190 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 768492011191 ArsC family; Region: ArsC; pfam03960 768492011192 catalytic residues [active] 768492011193 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492011194 DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420 768492011195 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 768492011196 uracil transporter; Provisional; Region: PRK10720 768492011197 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768492011198 active site 768492011199 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 768492011200 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 768492011201 dimerization interface [polypeptide binding]; other site 768492011202 putative ATP binding site [chemical binding]; other site 768492011203 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 768492011204 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 768492011205 active site 768492011206 substrate binding site [chemical binding]; other site 768492011207 cosubstrate binding site; other site 768492011208 catalytic site [active] 768492011209 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 768492011210 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 768492011211 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 768492011212 Protein of unknown function, DUF596; Region: DUF596; cl10492 768492011213 haemagglutination activity domain; Region: Haemagg_act; cl05436 768492011214 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 768492011215 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 768492011216 Surface antigen; Region: Bac_surface_Ag; cl03097 768492011217 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 768492011218 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 768492011219 Walker A/P-loop; other site 768492011220 ATP binding site [chemical binding]; other site 768492011221 Q-loop/lid; other site 768492011222 ABC transporter signature motif; other site 768492011223 Walker B; other site 768492011224 D-loop; other site 768492011225 H-loop/switch region; other site 768492011226 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 768492011227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492011228 dimer interface [polypeptide binding]; other site 768492011229 conserved gate region; other site 768492011230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 768492011231 ABC-ATPase subunit interface; other site 768492011232 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 768492011233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492011234 conserved gate region; other site 768492011235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492011236 conserved gate region; other site 768492011237 putative PBP binding loops; other site 768492011238 ABC-ATPase subunit interface; other site 768492011239 polyphosphate kinase; Provisional; Region: PRK05443 768492011240 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 768492011241 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 768492011242 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 768492011243 domain interface [polypeptide binding]; other site 768492011244 active site 768492011245 catalytic site [active] 768492011246 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 768492011247 domain interface [polypeptide binding]; other site 768492011248 active site 768492011249 catalytic site [active] 768492011250 exopolyphosphatase; Provisional; Region: PRK10854 768492011251 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 768492011252 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 768492011253 MgtE intracellular N domain; Region: MgtE_N; cl15244 768492011254 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 768492011255 Divalent cation transporter; Region: MgtE; cl00786 768492011256 MASE1; Region: MASE1; pfam05231 768492011257 putative diguanylate cyclase; Provisional; Region: PRK09776 768492011258 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768492011259 putative active site [active] 768492011260 heme pocket [chemical binding]; other site 768492011261 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768492011262 putative active site [active] 768492011263 heme pocket [chemical binding]; other site 768492011264 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768492011265 putative active site [active] 768492011266 heme pocket [chemical binding]; other site 768492011267 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768492011268 metal binding site [ion binding]; metal-binding site 768492011269 active site 768492011270 I-site; other site 768492011271 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768492011272 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 768492011273 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 768492011274 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 768492011275 AlkA N-terminal domain; Region: AlkA_N; cl05528 768492011276 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 768492011277 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 768492011278 minor groove reading motif; other site 768492011279 helix-hairpin-helix signature motif; other site 768492011280 substrate binding pocket [chemical binding]; other site 768492011281 active site 768492011282 putative chaperone; Provisional; Region: PRK11678 768492011283 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768492011284 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 768492011285 AAA domain; Region: AAA_33; pfam13671 768492011286 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 768492011287 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 768492011288 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768492011289 active site 768492011290 catalytic tetrad [active] 768492011291 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 768492011292 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 768492011293 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 768492011294 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 768492011295 Protein export membrane protein; Region: SecD_SecF; cl14618 768492011296 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 768492011297 putative transporter; Provisional; Region: PRK10504 768492011298 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492011299 putative substrate translocation pore; other site 768492011300 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 768492011301 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768492011302 dimerization interface [polypeptide binding]; other site 768492011303 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492011304 dimer interface [polypeptide binding]; other site 768492011305 phosphorylation site [posttranslational modification] 768492011306 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492011307 ATP binding site [chemical binding]; other site 768492011308 Mg2+ binding site [ion binding]; other site 768492011309 G-X-G motif; other site 768492011310 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 768492011311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492011312 active site 768492011313 phosphorylation site [posttranslational modification] 768492011314 intermolecular recognition site; other site 768492011315 dimerization interface [polypeptide binding]; other site 768492011316 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768492011317 DNA binding site [nucleotide binding] 768492011318 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 768492011319 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 768492011320 putative protease; Provisional; Region: PRK15452 768492011321 Peptidase family U32; Region: Peptidase_U32; cl03113 768492011322 lipid kinase; Reviewed; Region: PRK13054 768492011323 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 768492011324 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 768492011325 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 768492011326 putative active site pocket [active] 768492011327 putative metal binding site [ion binding]; other site 768492011328 putative oxidoreductase; Provisional; Region: PRK10083 768492011329 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 768492011330 putative NAD(P) binding site [chemical binding]; other site 768492011331 catalytic Zn binding site [ion binding]; other site 768492011332 structural Zn binding site [ion binding]; other site 768492011333 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492011334 D-galactonate transporter; Region: 2A0114; TIGR00893 768492011335 putative substrate translocation pore; other site 768492011336 D-mannonate oxidoreductase; Provisional; Region: PRK15037 768492011337 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 768492011338 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 768492011339 Transcriptional regulators [Transcription]; Region: GntR; COG1802 768492011340 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492011341 DNA-binding site [nucleotide binding]; DNA binding site 768492011342 FCD domain; Region: FCD; cl11656 768492011343 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 768492011344 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 768492011345 putative active site; other site 768492011346 catalytic residue [active] 768492011347 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 768492011348 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 768492011349 putative active site [active] 768492011350 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 768492011351 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; cl07428 768492011352 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 768492011353 dimer interface [polypeptide binding]; other site 768492011354 substrate binding site [chemical binding]; other site 768492011355 ATP binding site [chemical binding]; other site 768492011356 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 768492011357 substrate binding site [chemical binding]; other site 768492011358 multimerization interface [polypeptide binding]; other site 768492011359 ATP binding site [chemical binding]; other site 768492011360 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 768492011361 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492011362 Coenzyme A binding pocket [chemical binding]; other site 768492011363 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492011364 S-adenosylmethionine binding site [chemical binding]; other site 768492011365 Helix-turn-helix domains; Region: HTH; cl00088 768492011366 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 768492011367 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768492011368 RNA binding surface [nucleotide binding]; other site 768492011369 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 768492011370 probable active site [active] 768492011371 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 768492011372 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768492011373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492011374 active site 768492011375 phosphorylation site [posttranslational modification] 768492011376 intermolecular recognition site; other site 768492011377 dimerization interface [polypeptide binding]; other site 768492011378 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492011379 DNA binding residues [nucleotide binding] 768492011380 dimerization interface [polypeptide binding]; other site 768492011381 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768492011382 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492011383 dimer interface [polypeptide binding]; other site 768492011384 phosphorylation site [posttranslational modification] 768492011385 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492011386 ATP binding site [chemical binding]; other site 768492011387 Mg2+ binding site [ion binding]; other site 768492011388 G-X-G motif; other site 768492011389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492011390 Response regulator receiver domain; Region: Response_reg; pfam00072 768492011391 active site 768492011392 phosphorylation site [posttranslational modification] 768492011393 intermolecular recognition site; other site 768492011394 dimerization interface [polypeptide binding]; other site 768492011395 enoyl-CoA hydratase; Provisional; Region: PRK06688 768492011396 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768492011397 substrate binding site [chemical binding]; other site 768492011398 oxyanion hole (OAH) forming residues; other site 768492011399 trimer interface [polypeptide binding]; other site 768492011400 Helix-turn-helix domains; Region: HTH; cl00088 768492011401 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 768492011402 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492011403 Coenzyme A binding pocket [chemical binding]; other site 768492011404 Helix-turn-helix domains; Region: HTH; cl00088 768492011405 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 768492011406 Bacterial sugar transferase; Region: Bac_transf; cl00939 768492011407 Protein of unknown function (DUF342); Region: DUF342; pfam03961 768492011408 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 768492011409 GMP synthase; Reviewed; Region: guaA; PRK00074 768492011410 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 768492011411 AMP/PPi binding site [chemical binding]; other site 768492011412 candidate oxyanion hole; other site 768492011413 catalytic triad [active] 768492011414 potential glutamine specificity residues [chemical binding]; other site 768492011415 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 768492011416 ATP Binding subdomain [chemical binding]; other site 768492011417 Ligand Binding sites [chemical binding]; other site 768492011418 Dimerization subdomain; other site 768492011419 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 768492011420 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 768492011421 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 768492011422 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 768492011423 active site 768492011424 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 768492011425 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 768492011426 generic binding surface II; other site 768492011427 generic binding surface I; other site 768492011428 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 768492011429 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 768492011430 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 768492011431 putative active site [active] 768492011432 putative catalytic site [active] 768492011433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492011434 D-galactonate transporter; Region: 2A0114; TIGR00893 768492011435 putative substrate translocation pore; other site 768492011436 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768492011437 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492011438 DNA binding site [nucleotide binding] 768492011439 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 768492011440 ligand binding site [chemical binding]; other site 768492011441 dimerization interface [polypeptide binding]; other site 768492011442 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 768492011443 active site 768492011444 Zn binding site [ion binding]; other site 768492011445 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 768492011446 Membrane transport protein; Region: Mem_trans; cl09117 768492011447 GTP-binding protein Der; Reviewed; Region: PRK00093 768492011448 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 768492011449 G1 box; other site 768492011450 GTP/Mg2+ binding site [chemical binding]; other site 768492011451 Switch I region; other site 768492011452 G2 box; other site 768492011453 Switch II region; other site 768492011454 G3 box; other site 768492011455 G4 box; other site 768492011456 G5 box; other site 768492011457 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 768492011458 G1 box; other site 768492011459 GTP/Mg2+ binding site [chemical binding]; other site 768492011460 Switch I region; other site 768492011461 G2 box; other site 768492011462 G3 box; other site 768492011463 Switch II region; other site 768492011464 G4 box; other site 768492011465 G5 box; other site 768492011466 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 768492011467 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 768492011468 Trp docking motif [polypeptide binding]; other site 768492011469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 768492011470 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 768492011471 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 768492011472 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 768492011473 dimer interface [polypeptide binding]; other site 768492011474 motif 1; other site 768492011475 active site 768492011476 motif 2; other site 768492011477 motif 3; other site 768492011478 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 768492011479 anticodon binding site; other site 768492011480 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 768492011481 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 768492011482 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 768492011483 cytoskeletal protein RodZ; Provisional; Region: PRK10856 768492011484 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492011485 non-specific DNA binding site [nucleotide binding]; other site 768492011486 salt bridge; other site 768492011487 sequence-specific DNA binding site [nucleotide binding]; other site 768492011488 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 768492011489 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 768492011490 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768492011491 binding surface 768492011492 TPR motif; other site 768492011493 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 768492011494 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768492011495 FeS/SAM binding site; other site 768492011496 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 768492011497 active site 768492011498 multimer interface [polypeptide binding]; other site 768492011499 penicillin-binding protein 1C; Provisional; Region: PRK11240 768492011500 Transglycosylase; Region: Transgly; cl07896 768492011501 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 768492011502 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 768492011503 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 768492011504 MG2 domain; Region: A2M_N; pfam01835 768492011505 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 768492011506 Alpha-2-macroglobulin family; Region: A2M; pfam00207 768492011507 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 768492011508 surface patch; other site 768492011509 thioester region; other site 768492011510 specificity defining residues; other site 768492011511 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 768492011512 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 768492011513 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768492011514 active site turn [active] 768492011515 phosphorylation site [posttranslational modification] 768492011516 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 768492011517 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 768492011518 NAD binding site [chemical binding]; other site 768492011519 sugar binding site [chemical binding]; other site 768492011520 divalent metal binding site [ion binding]; other site 768492011521 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 768492011522 dimer interface [polypeptide binding]; other site 768492011523 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768492011524 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768492011525 putative active site [active] 768492011526 SseB protein; Region: SseB; cl06279 768492011527 aminopeptidase B; Provisional; Region: PRK05015 768492011528 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 768492011529 interface (dimer of trimers) [polypeptide binding]; other site 768492011530 Substrate-binding/catalytic site; other site 768492011531 Zn-binding sites [ion binding]; other site 768492011532 Iron-sulphur cluster assembly; Region: Fe-S_assembly; cl01123 768492011533 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768492011534 catalytic loop [active] 768492011535 iron binding site [ion binding]; other site 768492011536 chaperone protein HscA; Provisional; Region: hscA; PRK05183 768492011537 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 768492011538 co-chaperone HscB; Provisional; Region: hscB; PRK05014 768492011539 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 768492011540 HSP70 interaction site [polypeptide binding]; other site 768492011541 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 768492011542 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 768492011543 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 768492011544 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 768492011545 trimerization site [polypeptide binding]; other site 768492011546 active site 768492011547 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768492011548 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 768492011549 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492011550 catalytic residue [active] 768492011551 Helix-turn-helix domains; Region: HTH; cl00088 768492011552 Rrf2 family protein; Region: rrf2_super; TIGR00738 768492011553 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 768492011554 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 768492011555 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 768492011556 active site 768492011557 dimerization interface [polypeptide binding]; other site 768492011558 High-affinity nickel-transport protein; Region: NicO; cl00964 768492011559 Protein of unknown function (DUF1007); Region: DUF1007; cl01487 768492011560 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 768492011561 PRD domain; Region: PRD; cl15445 768492011562 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 768492011563 MFS_1 like family; Region: MFS_1_like; pfam12832 768492011564 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 768492011565 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 768492011566 dimer interface [polypeptide binding]; other site 768492011567 active site 768492011568 glycine-pyridoxal phosphate binding site [chemical binding]; other site 768492011569 folate binding site [chemical binding]; other site 768492011570 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 768492011571 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 768492011572 heme-binding site [chemical binding]; other site 768492011573 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 768492011574 FAD binding pocket [chemical binding]; other site 768492011575 FAD binding motif [chemical binding]; other site 768492011576 phosphate binding motif [ion binding]; other site 768492011577 beta-alpha-beta structure motif; other site 768492011578 NAD binding pocket [chemical binding]; other site 768492011579 Heme binding pocket [chemical binding]; other site 768492011580 Nitrogen regulatory protein P-II; Region: P-II; cl00412 768492011581 Nitrogen regulatory protein P-II; Region: P-II; smart00938 768492011582 NAD synthetase; Provisional; Region: PRK13981 768492011583 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 768492011584 multimer interface [polypeptide binding]; other site 768492011585 active site 768492011586 catalytic triad [active] 768492011587 protein interface 1 [polypeptide binding]; other site 768492011588 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 768492011589 homodimer interface [polypeptide binding]; other site 768492011590 NAD binding pocket [chemical binding]; other site 768492011591 ATP binding pocket [chemical binding]; other site 768492011592 Mg binding site [ion binding]; other site 768492011593 active-site loop [active] 768492011594 response regulator GlrR; Provisional; Region: PRK15115 768492011595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492011596 active site 768492011597 phosphorylation site [posttranslational modification] 768492011598 intermolecular recognition site; other site 768492011599 dimerization interface [polypeptide binding]; other site 768492011600 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492011601 Walker A motif; other site 768492011602 ATP binding site [chemical binding]; other site 768492011603 Walker B motif; other site 768492011604 arginine finger; other site 768492011605 YfhG lipoprotein; Region: Lipoprotein_20; cl08141 768492011606 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492011607 dimer interface [polypeptide binding]; other site 768492011608 phosphorylation site [posttranslational modification] 768492011609 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492011610 ATP binding site [chemical binding]; other site 768492011611 Mg2+ binding site [ion binding]; other site 768492011612 G-X-G motif; other site 768492011613 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 768492011614 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 768492011615 dimerization interface [polypeptide binding]; other site 768492011616 ATP binding site [chemical binding]; other site 768492011617 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 768492011618 dimerization interface [polypeptide binding]; other site 768492011619 ATP binding site [chemical binding]; other site 768492011620 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 768492011621 putative active site [active] 768492011622 catalytic triad [active] 768492011623 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 768492011624 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492011625 substrate binding pocket [chemical binding]; other site 768492011626 membrane-bound complex binding site; other site 768492011627 hinge residues; other site 768492011628 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 768492011629 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768492011630 catalytic residue [active] 768492011631 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 768492011632 nucleoside/Zn binding site; other site 768492011633 dimer interface [polypeptide binding]; other site 768492011634 catalytic motif [active] 768492011635 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 768492011636 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768492011637 active site turn [active] 768492011638 phosphorylation site [posttranslational modification] 768492011639 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 768492011640 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 768492011641 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 768492011642 putative active site [active] 768492011643 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768492011644 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 768492011645 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768492011646 putative active site [active] 768492011647 ferredoxin; Validated; Region: PRK07118 768492011648 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 768492011649 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 768492011650 active site 768492011651 hydrophilic channel; other site 768492011652 dimerization interface [polypeptide binding]; other site 768492011653 catalytic residues [active] 768492011654 active site lid [active] 768492011655 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 768492011656 Recombination protein O N terminal; Region: RecO_N; cl15812 768492011657 Recombination protein O C terminal; Region: RecO_C; pfam02565 768492011658 GTPase Era; Reviewed; Region: era; PRK00089 768492011659 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 768492011660 G1 box; other site 768492011661 GTP/Mg2+ binding site [chemical binding]; other site 768492011662 Switch I region; other site 768492011663 G2 box; other site 768492011664 Switch II region; other site 768492011665 G3 box; other site 768492011666 G4 box; other site 768492011667 G5 box; other site 768492011668 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 768492011669 ribonuclease III; Reviewed; Region: rnc; PRK00102 768492011670 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 768492011671 dimerization interface [polypeptide binding]; other site 768492011672 active site 768492011673 metal binding site [ion binding]; metal-binding site 768492011674 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 768492011675 dsRNA binding site [nucleotide binding]; other site 768492011676 signal peptidase I; Provisional; Region: PRK10861 768492011677 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 768492011678 Catalytic site [active] 768492011679 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 768492011680 GTP-binding protein LepA; Provisional; Region: PRK05433 768492011681 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 768492011682 G1 box; other site 768492011683 putative GEF interaction site [polypeptide binding]; other site 768492011684 GTP/Mg2+ binding site [chemical binding]; other site 768492011685 Switch I region; other site 768492011686 G2 box; other site 768492011687 G3 box; other site 768492011688 Switch II region; other site 768492011689 G4 box; other site 768492011690 G5 box; other site 768492011691 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 768492011692 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 768492011693 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 768492011694 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 768492011695 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 768492011696 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 768492011697 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 768492011698 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 768492011699 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 768492011700 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 768492011701 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768492011702 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768492011703 DNA binding residues [nucleotide binding] 768492011704 L-aspartate oxidase; Provisional; Region: PRK09077 768492011705 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492011706 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 768492011707 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 768492011708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492011709 S-adenosylmethionine binding site [chemical binding]; other site 768492011710 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 768492011711 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 768492011712 ATP binding site [chemical binding]; other site 768492011713 Mg++ binding site [ion binding]; other site 768492011714 motif III; other site 768492011715 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768492011716 nucleotide binding region [chemical binding]; other site 768492011717 ATP-binding site [chemical binding]; other site 768492011718 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 768492011719 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 768492011720 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 768492011721 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 768492011722 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 768492011723 ligand binding site [chemical binding]; other site 768492011724 active site 768492011725 UGI interface [polypeptide binding]; other site 768492011726 catalytic site [active] 768492011727 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 768492011728 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 768492011729 dimer interface [polypeptide binding]; other site 768492011730 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 768492011731 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 768492011732 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 768492011733 recombination and repair protein; Provisional; Region: PRK10869 768492011734 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 768492011735 Walker A/P-loop; other site 768492011736 ATP binding site [chemical binding]; other site 768492011737 Q-loop/lid; other site 768492011738 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 768492011739 ABC transporter signature motif; other site 768492011740 Walker B; other site 768492011741 D-loop; other site 768492011742 H-loop/switch region; other site 768492011743 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 768492011744 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 768492011745 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 768492011746 putative coenzyme Q binding site [chemical binding]; other site 768492011747 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 768492011748 SmpB-tmRNA interface; other site 768492011749 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492011750 Helix-turn-helix domains; Region: HTH; cl00088 768492011751 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492011752 dimerization interface [polypeptide binding]; other site 768492011753 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 768492011754 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 768492011755 potential catalytic triad [active] 768492011756 conserved cys residue [active] 768492011757 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768492011758 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768492011759 active site 768492011760 catalytic tetrad [active] 768492011761 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 768492011762 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 768492011763 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 768492011764 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 768492011765 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 768492011766 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 768492011767 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 768492011768 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 768492011769 putative NAD(P) binding site [chemical binding]; other site 768492011770 Helix-turn-helix domains; Region: HTH; cl00088 768492011771 WYL domain; Region: WYL; cl14852 768492011772 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492011773 Coenzyme A binding pocket [chemical binding]; other site 768492011774 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492011775 S-adenosylmethionine binding site [chemical binding]; other site 768492011776 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 768492011777 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 768492011778 DoxX; Region: DoxX; cl00976 768492011779 MbeD/MobD like; Region: MbeD_MobD; pfam04899 768492011780 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 768492011781 Protein of unknown function (DUF2002); Region: DUF2002; cl11580 768492011782 major facilitator superfamily transporter; Provisional; Region: PRK05122 768492011783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492011784 putative substrate translocation pore; other site 768492011785 Helix-turn-helix domain; Region: HTH_18; pfam12833 768492011786 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492011787 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 768492011788 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492011789 Helix-turn-helix domains; Region: HTH; cl00088 768492011790 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492011791 putative effector binding pocket; other site 768492011792 dimerization interface [polypeptide binding]; other site 768492011793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492011794 putative substrate translocation pore; other site 768492011795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492011796 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 768492011797 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 768492011798 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768492011799 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492011800 DNA-binding site [nucleotide binding]; DNA binding site 768492011801 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492011802 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492011803 homodimer interface [polypeptide binding]; other site 768492011804 catalytic residue [active] 768492011805 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 768492011806 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 768492011807 catalytic residues [active] 768492011808 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 768492011809 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 768492011810 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 768492011811 Class I ribonucleotide reductase; Region: RNR_I; cd01679 768492011812 active site 768492011813 dimer interface [polypeptide binding]; other site 768492011814 catalytic residues [active] 768492011815 effector binding site; other site 768492011816 R2 peptide binding site; other site 768492011817 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 768492011818 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 768492011819 dimer interface [polypeptide binding]; other site 768492011820 putative radical transfer pathway; other site 768492011821 diiron center [ion binding]; other site 768492011822 tyrosyl radical; other site 768492011823 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 768492011824 HicB family; Region: HicB; pfam05534 768492011825 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 768492011826 short chain dehydrogenase; Provisional; Region: PRK12937 768492011827 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 768492011828 NADP binding site [chemical binding]; other site 768492011829 homodimer interface [polypeptide binding]; other site 768492011830 active site 768492011831 substrate binding site [chemical binding]; other site 768492011832 transcriptional regulator; Provisional; Region: PRK10632 768492011833 Helix-turn-helix domains; Region: HTH; cl00088 768492011834 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 768492011835 putative effector binding pocket; other site 768492011836 putative dimerization interface [polypeptide binding]; other site 768492011837 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 768492011838 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 768492011839 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 768492011840 active site 768492011841 nucleophile elbow; other site 768492011842 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 768492011843 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 768492011844 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 768492011845 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492011846 ATP binding site [chemical binding]; other site 768492011847 Mg2+ binding site [ion binding]; other site 768492011848 G-X-G motif; other site 768492011849 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 768492011850 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492011851 active site 768492011852 phosphorylation site [posttranslational modification] 768492011853 intermolecular recognition site; other site 768492011854 dimerization interface [polypeptide binding]; other site 768492011855 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 768492011856 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 768492011857 Walker A/P-loop; other site 768492011858 ATP binding site [chemical binding]; other site 768492011859 Q-loop/lid; other site 768492011860 ABC transporter signature motif; other site 768492011861 Walker B; other site 768492011862 D-loop; other site 768492011863 H-loop/switch region; other site 768492011864 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 768492011865 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492011866 dimer interface [polypeptide binding]; other site 768492011867 conserved gate region; other site 768492011868 putative PBP binding loops; other site 768492011869 ABC-ATPase subunit interface; other site 768492011870 NMT1-like family; Region: NMT1_2; cl15260 768492011871 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 768492011872 NMT1-like family; Region: NMT1_2; cl15260 768492011873 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 768492011874 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 768492011875 Helix-turn-helix domains; Region: HTH; cl00088 768492011876 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 768492011877 putative dimerization interface [polypeptide binding]; other site 768492011878 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492011879 putative substrate translocation pore; other site 768492011880 Helix-turn-helix domains; Region: HTH; cl00088 768492011881 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768492011882 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 768492011883 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 768492011884 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 768492011885 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 768492011886 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 768492011887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492011888 putative substrate translocation pore; other site 768492011889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492011890 putative methyltransferase; Provisional; Region: PRK10864 768492011891 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 768492011892 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 768492011893 thioredoxin 2; Provisional; Region: PRK10996 768492011894 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 768492011895 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 768492011896 catalytic residues [active] 768492011897 DTW domain; Region: DTW; cl01221 768492011898 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 768492011899 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492011900 CoA-ligase; Region: Ligase_CoA; cl02894 768492011901 ATP-grasp domain; Region: ATP-grasp_4; cl03087 768492011902 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768492011903 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492011904 Coenzyme A binding pocket [chemical binding]; other site 768492011905 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 768492011906 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 768492011907 domain interface [polypeptide binding]; other site 768492011908 putative active site [active] 768492011909 catalytic site [active] 768492011910 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 768492011911 domain interface [polypeptide binding]; other site 768492011912 putative active site [active] 768492011913 catalytic site [active] 768492011914 Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; cl11574 768492011915 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 768492011916 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492011917 putative substrate translocation pore; other site 768492011918 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 768492011919 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492011920 active site 768492011921 motif I; other site 768492011922 motif II; other site 768492011923 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 768492011924 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 768492011925 Walker A/P-loop; other site 768492011926 ATP binding site [chemical binding]; other site 768492011927 Q-loop/lid; other site 768492011928 ABC transporter signature motif; other site 768492011929 Walker B; other site 768492011930 D-loop; other site 768492011931 H-loop/switch region; other site 768492011932 NIL domain; Region: NIL; cl09633 768492011933 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492011934 dimer interface [polypeptide binding]; other site 768492011935 conserved gate region; other site 768492011936 ABC-ATPase subunit interface; other site 768492011937 NMT1-like family; Region: NMT1_2; cl15260 768492011938 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 768492011939 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 768492011940 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 768492011941 homodimer interaction site [polypeptide binding]; other site 768492011942 cofactor binding site; other site 768492011943 prolyl-tRNA synthetase; Provisional; Region: PRK09194 768492011944 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 768492011945 dimer interface [polypeptide binding]; other site 768492011946 motif 1; other site 768492011947 active site 768492011948 motif 2; other site 768492011949 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 768492011950 putative deacylase active site [active] 768492011951 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 768492011952 active site 768492011953 motif 3; other site 768492011954 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 768492011955 anticodon binding site; other site 768492011956 NlpE N-terminal domain; Region: NlpE; cl01138 768492011957 RF-1 domain; Region: RF-1; cl02875 768492011958 YaeQ protein; Region: YaeQ; cl01913 768492011959 Uncharacterized protein family (UPF0253); Region: UPF0253; cl11640 768492011960 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 768492011961 Cytochrome c; Region: Cytochrom_C; cl11414 768492011962 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 768492011963 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 768492011964 Ligand Binding Site [chemical binding]; other site 768492011965 TilS substrate binding domain; Region: TilS; pfam09179 768492011966 B3/4 domain; Region: B3_4; cl11458 768492011967 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 768492011968 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768492011969 putative metal binding site [ion binding]; other site 768492011970 lysine decarboxylase LdcC; Provisional; Region: PRK15399 768492011971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 768492011972 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 768492011973 homodimer interface [polypeptide binding]; other site 768492011974 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492011975 catalytic residue [active] 768492011976 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 768492011977 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 768492011978 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 768492011979 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 768492011980 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 768492011981 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 768492011982 generic binding surface II; other site 768492011983 generic binding surface I; other site 768492011984 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 768492011985 RNA/DNA hybrid binding site [nucleotide binding]; other site 768492011986 active site 768492011987 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 768492011988 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 768492011989 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 768492011990 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 768492011991 active site 768492011992 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 768492011993 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 768492011994 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 768492011995 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 768492011996 trimer interface [polypeptide binding]; other site 768492011997 active site 768492011998 UDP-GlcNAc binding site [chemical binding]; other site 768492011999 lipid binding site [chemical binding]; lipid-binding site 768492012000 periplasmic chaperone; Provisional; Region: PRK10780 768492012001 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 768492012002 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 768492012003 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 768492012004 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 768492012005 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 768492012006 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 768492012007 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 768492012008 Surface antigen; Region: Bac_surface_Ag; cl03097 768492012009 zinc metallopeptidase RseP; Provisional; Region: PRK10779 768492012010 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 768492012011 active site 768492012012 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 768492012013 protein binding site [polypeptide binding]; other site 768492012014 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 768492012015 protein binding site [polypeptide binding]; other site 768492012016 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 768492012017 putative substrate binding region [chemical binding]; other site 768492012018 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 768492012019 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 768492012020 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 768492012021 catalytic residue [active] 768492012022 putative FPP diphosphate binding site; other site 768492012023 putative FPP binding hydrophobic cleft; other site 768492012024 dimer interface [polypeptide binding]; other site 768492012025 putative IPP diphosphate binding site; other site 768492012026 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 768492012027 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 768492012028 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 768492012029 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 768492012030 ribosome recycling factor; Reviewed; Region: frr; PRK00083 768492012031 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 768492012032 hinge region; other site 768492012033 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 768492012034 putative nucleotide binding site [chemical binding]; other site 768492012035 uridine monophosphate binding site [chemical binding]; other site 768492012036 homohexameric interface [polypeptide binding]; other site 768492012037 elongation factor Ts; Provisional; Region: tsf; PRK09377 768492012038 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 768492012039 Elongation factor TS; Region: EF_TS; pfam00889 768492012040 Elongation factor TS; Region: EF_TS; pfam00889 768492012041 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 768492012042 rRNA interaction site [nucleotide binding]; other site 768492012043 S8 interaction site; other site 768492012044 putative laminin-1 binding site; other site 768492012045 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 768492012046 active site 768492012047 PII uridylyl-transferase; Provisional; Region: PRK05007 768492012048 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 768492012049 metal binding triad; other site 768492012050 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 768492012051 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 768492012052 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 768492012053 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 768492012054 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 768492012055 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 768492012056 trimer interface [polypeptide binding]; other site 768492012057 active site 768492012058 substrate binding site [chemical binding]; other site 768492012059 CoA binding site [chemical binding]; other site 768492012060 Protein of unknown function (DUF3461); Region: DUF3461; cl10125 768492012061 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 768492012062 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 768492012063 probable active site [active] 768492012064 tRNA pseudouridine synthase C; Region: DUF446; cl01187 768492012065 benzoate transport; Region: 2A0115; TIGR00895 768492012066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492012067 putative substrate translocation pore; other site 768492012068 Syd protein (SUKH-2); Region: Syd; cl06405 768492012069 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 768492012070 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 768492012071 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 768492012072 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 768492012073 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 768492012074 flap endonuclease-like protein; Provisional; Region: PRK09482 768492012075 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 768492012076 active site 768492012077 metal binding site 1 [ion binding]; metal-binding site 768492012078 putative 5' ssDNA interaction site; other site 768492012079 metal binding site 3; metal-binding site 768492012080 metal binding site 2 [ion binding]; metal-binding site 768492012081 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 768492012082 putative DNA binding site [nucleotide binding]; other site 768492012083 putative metal binding site [ion binding]; other site 768492012084 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 768492012085 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 768492012086 Protein of unknown function (DUF423); Region: DUF423; cl01008 768492012087 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768492012088 Helix-turn-helix domains; Region: HTH; cl00088 768492012089 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 768492012090 dimerization interface [polypeptide binding]; other site 768492012091 substrate binding pocket [chemical binding]; other site 768492012092 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 768492012093 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 768492012094 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 768492012095 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492012096 catalytic residue [active] 768492012097 Fe-S metabolism associated domain; Region: SufE; cl00951 768492012098 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 768492012099 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 768492012100 putative ATP binding site [chemical binding]; other site 768492012101 putative substrate interface [chemical binding]; other site 768492012102 murein transglycosylase A; Provisional; Region: mltA; PRK11162 768492012103 MltA specific insert domain; Region: MltA; cl08398 768492012104 3D domain; Region: 3D; cl01439 768492012105 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 768492012106 AMIN domain; Region: AMIN; pfam11741 768492012107 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 768492012108 active site 768492012109 metal binding site [ion binding]; metal-binding site 768492012110 N-acetylglutamate synthase; Validated; Region: PRK05279 768492012111 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 768492012112 putative feedback inhibition sensing region; other site 768492012113 putative nucleotide binding site [chemical binding]; other site 768492012114 putative substrate binding site [chemical binding]; other site 768492012115 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492012116 Coenzyme A binding pocket [chemical binding]; other site 768492012117 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 768492012118 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492012119 Family description; Region: UvrD_C_2; cl15862 768492012120 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 768492012121 protease3; Provisional; Region: PRK15101 768492012122 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 768492012123 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 768492012124 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 768492012125 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 768492012126 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 768492012127 hypothetical protein; Provisional; Region: PRK10332 768492012128 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 768492012129 Protein of unknown function (DUF2509); Region: DUF2509; cl11672 768492012130 hypothetical protein; Provisional; Region: PRK10557 768492012131 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 768492012132 hypothetical protein; Provisional; Region: PRK10506 768492012133 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 768492012134 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 768492012135 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 768492012136 dimerization interface [polypeptide binding]; other site 768492012137 active site 768492012138 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 768492012139 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 768492012140 GAF domain; Region: GAF; cl15785 768492012141 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 768492012142 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 768492012143 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 768492012144 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 768492012145 putative active site [active] 768492012146 Ap4A binding site [chemical binding]; other site 768492012147 nudix motif; other site 768492012148 putative metal binding site [ion binding]; other site 768492012149 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 768492012150 putative DNA-binding cleft [nucleotide binding]; other site 768492012151 putative DNA clevage site; other site 768492012152 molecular lever; other site 768492012153 Integral membrane protein TerC family; Region: TerC; cl10468 768492012154 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 768492012155 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 768492012156 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768492012157 active site 768492012158 catalytic tetrad [active] 768492012159 lysophospholipid transporter LplT; Provisional; Region: PRK11195 768492012160 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492012161 putative substrate translocation pore; other site 768492012162 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 768492012163 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 768492012164 putative acyl-acceptor binding pocket; other site 768492012165 AMP-binding enzyme; Region: AMP-binding; cl15778 768492012166 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 768492012167 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 768492012168 molybdopterin cofactor binding site [chemical binding]; other site 768492012169 substrate binding site [chemical binding]; other site 768492012170 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 768492012171 molybdopterin cofactor binding site; other site 768492012172 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 768492012173 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492012174 DNA binding site [nucleotide binding] 768492012175 domain linker motif; other site 768492012176 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 768492012177 dimerization interface (closed form) [polypeptide binding]; other site 768492012178 ligand binding site [chemical binding]; other site 768492012179 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492012180 Coenzyme A binding pocket [chemical binding]; other site 768492012181 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768492012182 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492012183 DNA binding site [nucleotide binding] 768492012184 domain linker motif; other site 768492012185 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 768492012186 dimerization interface (closed form) [polypeptide binding]; other site 768492012187 ligand binding site [chemical binding]; other site 768492012188 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 768492012189 diaminopimelate decarboxylase; Provisional; Region: PRK11165 768492012190 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 768492012191 active site 768492012192 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768492012193 substrate binding site [chemical binding]; other site 768492012194 catalytic residues [active] 768492012195 dimer interface [polypeptide binding]; other site 768492012196 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 768492012197 Helix-turn-helix domains; Region: HTH; cl00088 768492012198 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492012199 dimerization interface [polypeptide binding]; other site 768492012200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492012201 putative substrate translocation pore; other site 768492012202 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768492012203 transcriptional activator TtdR; Provisional; Region: PRK09801 768492012204 Helix-turn-helix domains; Region: HTH; cl00088 768492012205 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492012206 putative effector binding pocket; other site 768492012207 dimerization interface [polypeptide binding]; other site 768492012208 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 768492012209 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 768492012210 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 768492012211 catalytic residues [active] 768492012212 Tetratricopeptide repeat; Region: TPR_12; pfam13424 768492012213 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 768492012214 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 768492012215 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223 768492012216 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 768492012217 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 768492012218 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 768492012219 Walker A/P-loop; other site 768492012220 ATP binding site [chemical binding]; other site 768492012221 Q-loop/lid; other site 768492012222 ABC transporter signature motif; other site 768492012223 Walker B; other site 768492012224 D-loop; other site 768492012225 H-loop/switch region; other site 768492012226 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768492012227 active site 768492012228 DNA binding site [nucleotide binding] 768492012229 Int/Topo IB signature motif; other site 768492012230 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768492012231 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492012232 DNA binding residues [nucleotide binding] 768492012233 dimerization interface [polypeptide binding]; other site 768492012234 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768492012235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 768492012236 active site 768492012237 phosphorylation site [posttranslational modification] 768492012238 intermolecular recognition site; other site 768492012239 dimerization interface [polypeptide binding]; other site 768492012240 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492012241 DNA binding residues [nucleotide binding] 768492012242 dimerization interface [polypeptide binding]; other site 768492012243 Fimbrial protein; Region: Fimbrial; cl01416 768492012244 Fimbrial protein; Region: Fimbrial; cl01416 768492012245 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 768492012246 PapC N-terminal domain; Region: PapC_N; pfam13954 768492012247 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 768492012248 PapC C-terminal domain; Region: PapC_C; pfam13953 768492012249 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 768492012250 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 768492012251 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 768492012252 Fimbrial protein; Region: Fimbrial; cl01416 768492012253 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768492012254 active site 768492012255 DNA binding site [nucleotide binding] 768492012256 Int/Topo IB signature motif; other site 768492012257 Phosphopantetheine attachment site; Region: PP-binding; cl09936 768492012258 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 768492012259 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 768492012260 dimer interface [polypeptide binding]; other site 768492012261 active site 768492012262 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 768492012263 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 768492012264 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 768492012265 Walker A/P-loop; other site 768492012266 ATP binding site [chemical binding]; other site 768492012267 Q-loop/lid; other site 768492012268 ABC transporter signature motif; other site 768492012269 Walker B; other site 768492012270 D-loop; other site 768492012271 H-loop/switch region; other site 768492012272 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768492012273 FtsX-like permease family; Region: FtsX; cl15850 768492012274 macrolide transporter subunit MacA; Provisional; Region: PRK11578 768492012275 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 768492012276 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 768492012277 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 768492012278 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 768492012279 putative active site [active] 768492012280 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 768492012281 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492012282 Walker A/P-loop; other site 768492012283 ATP binding site [chemical binding]; other site 768492012284 Q-loop/lid; other site 768492012285 ABC transporter signature motif; other site 768492012286 Walker B; other site 768492012287 D-loop; other site 768492012288 H-loop/switch region; other site 768492012289 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 768492012290 catalytic residues [active] 768492012291 hinge region; other site 768492012292 alpha helical domain; other site 768492012293 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492012294 Helix-turn-helix domains; Region: HTH; cl00088 768492012295 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492012296 putative effector binding pocket; other site 768492012297 dimerization interface [polypeptide binding]; other site 768492012298 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 768492012299 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 768492012300 phosphate binding site [ion binding]; other site 768492012301 BCCT family transporter; Region: BCCT; cl00569 768492012302 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 768492012303 Helix-turn-helix domains; Region: HTH; cl00088 768492012304 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 768492012305 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492012306 Helix-turn-helix domains; Region: HTH; cl00088 768492012307 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492012308 putative effector binding pocket; other site 768492012309 dimerization interface [polypeptide binding]; other site 768492012310 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 768492012311 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 768492012312 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 768492012313 ATM1 is an ABC transporter that is expressed in the mitochondria. Although the specific function of ATM1 is unknown, its disruption results in the accumulation of excess mitochondrial iron, loss of mitochondrial cytochromes, oxidative damage to...; Region: ABCC_ATM1_transporter; cd03253 768492012314 Walker A/P-loop; other site 768492012315 ATP binding site [chemical binding]; other site 768492012316 Q-loop/lid; other site 768492012317 ABC transporter signature motif; other site 768492012318 Walker B; other site 768492012319 D-loop; other site 768492012320 H-loop/switch region; other site 768492012321 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 768492012322 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 768492012323 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 768492012324 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768492012325 Cytochrome c; Region: Cytochrom_C; cl11414 768492012326 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 768492012327 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 768492012328 putative peptidoglycan binding site; other site 768492012329 acid-resistance membrane protein; Provisional; Region: PRK10209 768492012330 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 768492012331 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 768492012332 HSP70 interaction site [polypeptide binding]; other site 768492012333 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 768492012334 substrate binding site [polypeptide binding]; other site 768492012335 dimer interface [polypeptide binding]; other site 768492012336 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 768492012337 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 768492012338 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492012339 Helix-turn-helix domains; Region: HTH; cl00088 768492012340 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492012341 dimerization interface [polypeptide binding]; other site 768492012342 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 768492012343 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 768492012344 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 768492012345 DNA-binding site [nucleotide binding]; DNA binding site 768492012346 RNA-binding motif; other site 768492012347 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 768492012348 Excisionase-like protein; Region: Exc; pfam07825 768492012349 Excisionase-like protein; Region: Exc; pfam07825 768492012350 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 768492012351 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 768492012352 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 768492012353 Domain of unknown function (DUF927); Region: DUF927; cl12098 768492012354 AntA/AntB antirepressor; Region: AntA; cl01430 768492012355 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 768492012356 integrase; Provisional; Region: PRK09692 768492012357 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 768492012358 active site 768492012359 Int/Topo IB signature motif; other site 768492012360 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 768492012361 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 768492012362 dimer interface [polypeptide binding]; other site 768492012363 putative anticodon binding site; other site 768492012364 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 768492012365 motif 1; other site 768492012366 active site 768492012367 motif 2; other site 768492012368 motif 3; other site 768492012369 peptide chain release factor 2; Validated; Region: prfB; PRK00578 768492012370 RF-1 domain; Region: RF-1; cl02875 768492012371 RF-1 domain; Region: RF-1; cl02875 768492012372 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 768492012373 DHH family; Region: DHH; pfam01368 768492012374 DHHA1 domain; Region: DHHA1; pfam02272 768492012375 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 768492012376 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 768492012377 dimerization domain [polypeptide binding]; other site 768492012378 dimer interface [polypeptide binding]; other site 768492012379 catalytic residues [active] 768492012380 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 768492012381 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 768492012382 active site 768492012383 Int/Topo IB signature motif; other site 768492012384 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 768492012385 Inner membrane protein CreD; Region: CreD; cl01844 768492012386 sensory histidine kinase CreC; Provisional; Region: PRK11100 768492012387 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768492012388 dimerization interface [polypeptide binding]; other site 768492012389 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492012390 dimer interface [polypeptide binding]; other site 768492012391 phosphorylation site [posttranslational modification] 768492012392 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492012393 ATP binding site [chemical binding]; other site 768492012394 Mg2+ binding site [ion binding]; other site 768492012395 G-X-G motif; other site 768492012396 DNA-binding response regulator CreB; Provisional; Region: PRK11083 768492012397 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492012398 active site 768492012399 phosphorylation site [posttranslational modification] 768492012400 intermolecular recognition site; other site 768492012401 dimerization interface [polypeptide binding]; other site 768492012402 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768492012403 DNA binding site [nucleotide binding] 768492012404 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 768492012405 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 768492012406 putative global regulator; Reviewed; Region: PRK09559 768492012407 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 768492012408 Haemolysin-III related; Region: HlyIII; cl03831 768492012409 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 768492012410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492012411 metabolite-proton symporter; Region: 2A0106; TIGR00883 768492012412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492012413 amidase; Provisional; Region: PRK07056 768492012414 Amidase; Region: Amidase; cl11426 768492012415 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 768492012416 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492012417 DNA-binding site [nucleotide binding]; DNA binding site 768492012418 FCD domain; Region: FCD; cl11656 768492012419 short chain dehydrogenase; Provisional; Region: PRK06123 768492012420 classical (c) SDRs; Region: SDR_c; cd05233 768492012421 NAD(P) binding site [chemical binding]; other site 768492012422 active site 768492012423 MltA-interacting protein MipA; Region: MipA; cl01504 768492012424 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 768492012425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492012426 active site 768492012427 phosphorylation site [posttranslational modification] 768492012428 intermolecular recognition site; other site 768492012429 dimerization interface [polypeptide binding]; other site 768492012430 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768492012431 DNA binding site [nucleotide binding] 768492012432 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 768492012433 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492012434 dimer interface [polypeptide binding]; other site 768492012435 phosphorylation site [posttranslational modification] 768492012436 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492012437 ATP binding site [chemical binding]; other site 768492012438 Mg2+ binding site [ion binding]; other site 768492012439 G-X-G motif; other site 768492012440 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 768492012441 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 768492012442 NAD(P) binding site [chemical binding]; other site 768492012443 glycine dehydrogenase; Provisional; Region: PRK05367 768492012444 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 768492012445 tetramer interface [polypeptide binding]; other site 768492012446 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492012447 catalytic residue [active] 768492012448 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 768492012449 tetramer interface [polypeptide binding]; other site 768492012450 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492012451 catalytic residue [active] 768492012452 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 768492012453 lipoyl attachment site [posttranslational modification]; other site 768492012454 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 768492012455 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 768492012456 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492012457 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 768492012458 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492012459 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 768492012460 proline aminopeptidase P II; Provisional; Region: PRK10879 768492012461 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 768492012462 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 768492012463 active site 768492012464 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 768492012465 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 768492012466 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 768492012467 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492012468 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 768492012469 L-serine binding site [chemical binding]; other site 768492012470 ACT domain interface; other site 768492012471 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 768492012472 tetramer (dimer of dimers) interface [polypeptide binding]; other site 768492012473 active site 768492012474 dimer interface [polypeptide binding]; other site 768492012475 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 768492012476 Helix-turn-helix domains; Region: HTH; cl00088 768492012477 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 768492012478 putative dimerization interface [polypeptide binding]; other site 768492012479 Protein of unknown function (DUF541); Region: SIMPL; cl01077 768492012480 LysE type translocator; Region: LysE; cl00565 768492012481 Transcriptional regulator [Transcription]; Region: IclR; COG1414 768492012482 Helix-turn-helix domains; Region: HTH; cl00088 768492012483 Bacterial transcriptional regulator; Region: IclR; pfam01614 768492012484 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 768492012485 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 768492012486 Walker A/P-loop; other site 768492012487 ATP binding site [chemical binding]; other site 768492012488 Q-loop/lid; other site 768492012489 ABC transporter signature motif; other site 768492012490 Walker B; other site 768492012491 D-loop; other site 768492012492 H-loop/switch region; other site 768492012493 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 768492012494 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768492012495 TM-ABC transporter signature motif; other site 768492012496 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 768492012497 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_6; cd06315 768492012498 putative ligand binding site [chemical binding]; other site 768492012499 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 768492012500 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 768492012501 Domain of unknown function (DUF386); Region: DUF386; cl01047 768492012502 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492012503 D-galactonate transporter; Region: 2A0114; TIGR00893 768492012504 putative substrate translocation pore; other site 768492012505 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 768492012506 L-xylulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 768492012507 putative N- and C-terminal domain interface [polypeptide binding]; other site 768492012508 putative active site [active] 768492012509 putative MgATP binding site [chemical binding]; other site 768492012510 catalytic site [active] 768492012511 metal binding site [ion binding]; metal-binding site 768492012512 putative xylulose binding site [chemical binding]; other site 768492012513 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 768492012514 active site 768492012515 dimer interface [polypeptide binding]; other site 768492012516 magnesium binding site [ion binding]; other site 768492012517 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 768492012518 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 768492012519 AP (apurinic/apyrimidinic) site pocket; other site 768492012520 DNA interaction; other site 768492012521 Metal-binding active site; metal-binding site 768492012522 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 768492012523 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 768492012524 intersubunit interface [polypeptide binding]; other site 768492012525 active site 768492012526 Zn2+ binding site [ion binding]; other site 768492012527 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 768492012528 active site 768492012529 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201 768492012530 mechanosensitive channel MscS; Provisional; Region: PRK10334 768492012531 Mechanosensitive ion channel; Region: MS_channel; pfam00924 768492012532 Protein of unknown function (DUF1345); Region: DUF1345; cl01753 768492012533 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 768492012534 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 768492012535 active site 768492012536 intersubunit interface [polypeptide binding]; other site 768492012537 zinc binding site [ion binding]; other site 768492012538 Na+ binding site [ion binding]; other site 768492012539 Phosphoglycerate kinase; Region: PGK; pfam00162 768492012540 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 768492012541 substrate binding site [chemical binding]; other site 768492012542 hinge regions; other site 768492012543 ADP binding site [chemical binding]; other site 768492012544 catalytic site [active] 768492012545 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 768492012546 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492012547 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 768492012548 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 768492012549 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492012550 Walker A/P-loop; other site 768492012551 ATP binding site [chemical binding]; other site 768492012552 Q-loop/lid; other site 768492012553 ABC transporter signature motif; other site 768492012554 Walker B; other site 768492012555 D-loop; other site 768492012556 H-loop/switch region; other site 768492012557 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 768492012558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492012559 dimer interface [polypeptide binding]; other site 768492012560 conserved gate region; other site 768492012561 ABC-ATPase subunit interface; other site 768492012562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492012563 dimer interface [polypeptide binding]; other site 768492012564 conserved gate region; other site 768492012565 putative PBP binding loops; other site 768492012566 ABC-ATPase subunit interface; other site 768492012567 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 768492012568 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492012569 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768492012570 catalytic core [active] 768492012571 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 768492012572 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 768492012573 transmembrane helices; other site 768492012574 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492012575 Helix-turn-helix domains; Region: HTH; cl00088 768492012576 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 768492012577 putative dimerization interface [polypeptide binding]; other site 768492012578 transketolase; Reviewed; Region: PRK12753 768492012579 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 768492012580 TPP-binding site [chemical binding]; other site 768492012581 dimer interface [polypeptide binding]; other site 768492012582 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 768492012583 PYR/PP interface [polypeptide binding]; other site 768492012584 dimer interface [polypeptide binding]; other site 768492012585 TPP binding site [chemical binding]; other site 768492012586 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768492012587 Peptidase family M48; Region: Peptidase_M48; cl12018 768492012588 hypothetical protein; Provisional; Region: PRK07064 768492012589 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768492012590 PYR/PP interface [polypeptide binding]; other site 768492012591 dimer interface [polypeptide binding]; other site 768492012592 TPP binding site [chemical binding]; other site 768492012593 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 768492012594 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 768492012595 TPP-binding site [chemical binding]; other site 768492012596 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 768492012597 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 768492012598 NAD(P) binding site [chemical binding]; other site 768492012599 catalytic residues [active] 768492012600 L-aspartate dehydrogenase; Provisional; Region: PRK13303 768492012601 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492012602 Domain of unknown function DUF108; Region: DUF108; pfam01958 768492012603 short chain dehydrogenase; Provisional; Region: PRK07062 768492012604 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492012605 NAD(P) binding site [chemical binding]; other site 768492012606 active site 768492012607 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768492012608 Cupin domain; Region: Cupin_2; cl09118 768492012609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492012610 D-galactonate transporter; Region: 2A0114; TIGR00893 768492012611 putative substrate translocation pore; other site 768492012612 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 768492012613 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768492012614 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 768492012615 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768492012616 putative active site [active] 768492012617 putative metal binding site [ion binding]; other site 768492012618 Transcriptional regulator [Transcription]; Region: IclR; COG1414 768492012619 Helix-turn-helix domains; Region: HTH; cl00088 768492012620 Bacterial transcriptional regulator; Region: IclR; pfam01614 768492012621 short chain dehydrogenase; Provisional; Region: PRK12939 768492012622 classical (c) SDRs; Region: SDR_c; cd05233 768492012623 NAD(P) binding site [chemical binding]; other site 768492012624 active site 768492012625 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 768492012626 [2Fe-2S] cluster binding site [ion binding]; other site 768492012627 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 768492012628 hydrophobic ligand binding site; other site 768492012629 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 768492012630 [2Fe-2S] cluster binding site [ion binding]; other site 768492012631 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 768492012632 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768492012633 RNA binding surface [nucleotide binding]; other site 768492012634 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 768492012635 probable active site [active] 768492012636 Arginase family; Region: Arginase; cl00306 768492012637 arginine decarboxylase; Provisional; Region: PRK05354 768492012638 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 768492012639 dimer interface [polypeptide binding]; other site 768492012640 active site 768492012641 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768492012642 catalytic residues [active] 768492012643 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 768492012644 S-adenosylmethionine synthetase; Validated; Region: PRK05250 768492012645 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 768492012646 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 768492012647 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 768492012648 Hok/gef family; Region: HOK_GEF; cl11494 768492012649 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 768492012650 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768492012651 ABC-ATPase subunit interface; other site 768492012652 dimer interface [polypeptide binding]; other site 768492012653 putative PBP binding regions; other site 768492012654 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768492012655 ABC-ATPase subunit interface; other site 768492012656 dimer interface [polypeptide binding]; other site 768492012657 putative PBP binding regions; other site 768492012658 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 768492012659 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 768492012660 siderophore binding site; other site 768492012661 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 768492012662 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768492012663 Walker A/P-loop; other site 768492012664 ATP binding site [chemical binding]; other site 768492012665 Q-loop/lid; other site 768492012666 ABC transporter signature motif; other site 768492012667 Walker B; other site 768492012668 D-loop; other site 768492012669 H-loop/switch region; other site 768492012670 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 768492012671 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768492012672 N-terminal plug; other site 768492012673 ligand-binding site [chemical binding]; other site 768492012674 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 768492012675 Transglycosylase; Region: Transgly; cl07896 768492012676 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 768492012677 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 768492012678 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768492012679 ATP binding site [chemical binding]; other site 768492012680 putative Mg++ binding site [ion binding]; other site 768492012681 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768492012682 nucleotide binding region [chemical binding]; other site 768492012683 ATP-binding site [chemical binding]; other site 768492012684 Helicase associated domain (HA2); Region: HA2; cl04503 768492012685 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 768492012686 2'-5' RNA ligase; Provisional; Region: PRK15124 768492012687 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 768492012688 Sugar fermentation stimulation protein; Region: SfsA; cl00647 768492012689 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 768492012690 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768492012691 active site 768492012692 nucleotide binding site [chemical binding]; other site 768492012693 HIGH motif; other site 768492012694 KMSKS motif; other site 768492012695 poly(A) polymerase; Region: pcnB; TIGR01942 768492012696 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 768492012697 active site 768492012698 NTP binding site [chemical binding]; other site 768492012699 metal binding triad [ion binding]; metal-binding site 768492012700 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 768492012701 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 768492012702 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 768492012703 catalytic center binding site [active] 768492012704 ATP binding site [chemical binding]; other site 768492012705 sensor protein QseC; Provisional; Region: PRK10337 768492012706 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 768492012707 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492012708 dimer interface [polypeptide binding]; other site 768492012709 phosphorylation site [posttranslational modification] 768492012710 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492012711 ATP binding site [chemical binding]; other site 768492012712 Mg2+ binding site [ion binding]; other site 768492012713 G-X-G motif; other site 768492012714 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 768492012715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492012716 active site 768492012717 phosphorylation site [posttranslational modification] 768492012718 intermolecular recognition site; other site 768492012719 dimerization interface [polypeptide binding]; other site 768492012720 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768492012721 DNA binding site [nucleotide binding] 768492012722 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 768492012723 oligomerization interface [polypeptide binding]; other site 768492012724 active site 768492012725 metal binding site [ion binding]; metal-binding site 768492012726 Pantoate-beta-alanine ligase; Region: PanC; cd00560 768492012727 pantoate--beta-alanine ligase; Region: panC; TIGR00018 768492012728 active site 768492012729 ATP-binding site [chemical binding]; other site 768492012730 pantoate-binding site; other site 768492012731 HXXH motif; other site 768492012732 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 768492012733 tetramerization interface [polypeptide binding]; other site 768492012734 active site 768492012735 Bacterial SH3 domain; Region: SH3_3; cl02551 768492012736 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 768492012737 putative active site [active] 768492012738 putative metal binding site [ion binding]; other site 768492012739 ABC-2 type transporter; Region: ABC2_membrane; cl11417 768492012740 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 768492012741 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 768492012742 Walker A/P-loop; other site 768492012743 ATP binding site [chemical binding]; other site 768492012744 Q-loop/lid; other site 768492012745 ABC transporter signature motif; other site 768492012746 Walker B; other site 768492012747 D-loop; other site 768492012748 H-loop/switch region; other site 768492012749 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 768492012750 active site clefts [active] 768492012751 zinc binding site [ion binding]; other site 768492012752 dimer interface [polypeptide binding]; other site 768492012753 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768492012754 active site 768492012755 multicopper oxidase; Provisional; Region: PRK10965 768492012756 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 768492012757 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 768492012758 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 768492012759 spermidine synthase; Provisional; Region: PRK00811 768492012760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492012761 S-adenosylmethionine binding site [chemical binding]; other site 768492012762 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 768492012763 Uncharacterized protein family (UPF0231); Region: UPF0231; cl11474 768492012764 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 768492012765 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 768492012766 substrate binding site [chemical binding]; other site 768492012767 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 768492012768 substrate binding site [chemical binding]; other site 768492012769 ligand binding site [chemical binding]; other site 768492012770 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 768492012771 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492012772 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768492012773 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768492012774 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 768492012775 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768492012776 E3 interaction surface; other site 768492012777 lipoyl attachment site [posttranslational modification]; other site 768492012778 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768492012779 E3 interaction surface; other site 768492012780 lipoyl attachment site [posttranslational modification]; other site 768492012781 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768492012782 E3 interaction surface; other site 768492012783 lipoyl attachment site [posttranslational modification]; other site 768492012784 e3 binding domain; Region: E3_binding; pfam02817 768492012785 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 768492012786 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 768492012787 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 768492012788 dimer interface [polypeptide binding]; other site 768492012789 TPP-binding site [chemical binding]; other site 768492012790 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 768492012791 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492012792 DNA-binding site [nucleotide binding]; DNA binding site 768492012793 FCD domain; Region: FCD; cl11656 768492012794 aromatic amino acid transporter; Provisional; Region: PRK10238 768492012795 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 768492012796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492012797 putative substrate translocation pore; other site 768492012798 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 768492012799 active site 768492012800 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768492012801 Cytochrome c; Region: Cytochrom_C; cl11414 768492012802 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 768492012803 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 768492012804 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 768492012805 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768492012806 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 768492012807 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768492012808 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 768492012809 Ligand binding site; other site 768492012810 metal-binding site 768492012811 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 768492012812 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 768492012813 XdhC Rossmann domain; Region: XdhC_C; pfam13478 768492012814 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 768492012815 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492012816 fumarate hydratase; Provisional; Region: PRK15389 768492012817 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 768492012818 Fumarase C-terminus; Region: Fumerase_C; cl00795 768492012819 hypothetical protein; Provisional; Region: PRK04860 768492012820 SprT homologues; Region: SprT; cl01182 768492012821 DNA-specific endonuclease I; Provisional; Region: PRK15137 768492012822 Endonuclease I; Region: Endonuclease_1; cl01003 768492012823 RNA methyltransferase, RsmE family; Region: TIGR00046 768492012824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 768492012825 glutathione synthetase; Provisional; Region: PRK05246 768492012826 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 768492012827 ATP-grasp domain; Region: ATP-grasp_4; cl03087 768492012828 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 768492012829 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 768492012830 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 768492012831 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 768492012832 Walker A motif; other site 768492012833 ATP binding site [chemical binding]; other site 768492012834 Walker B motif; other site 768492012835 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 768492012836 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768492012837 catalytic residue [active] 768492012838 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 768492012839 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492012840 YGGT family; Region: YGGT; cl00508 768492012841 YGGT family; Region: YGGT; cl00508 768492012842 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 768492012843 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 768492012844 active site 768492012845 dimerization interface [polypeptide binding]; other site 768492012846 HemN family oxidoreductase; Provisional; Region: PRK05660 768492012847 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768492012848 FeS/SAM binding site; other site 768492012849 HemN C-terminal domain; Region: HemN_C; pfam06969 768492012850 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 768492012851 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 768492012852 Protein of unknown function (DUF2884); Region: DUF2884; cl08135 768492012853 Glutaminase; Region: Glutaminase; cl00907 768492012854 Protein with unknown function (DUF469); Region: DUF469; cl01237 768492012855 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 768492012856 adenine DNA glycosylase; Provisional; Region: PRK10880 768492012857 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 768492012858 minor groove reading motif; other site 768492012859 helix-hairpin-helix signature motif; other site 768492012860 substrate binding pocket [chemical binding]; other site 768492012861 active site 768492012862 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 768492012863 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 768492012864 DNA binding and oxoG recognition site [nucleotide binding] 768492012865 Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104 768492012866 murein transglycosylase C; Provisional; Region: mltC; PRK11671 768492012867 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 768492012868 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 768492012869 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768492012870 catalytic residue [active] 768492012871 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 768492012872 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 768492012873 dimer interface [polypeptide binding]; other site 768492012874 Citrate synthase; Region: Citrate_synt; pfam00285 768492012875 active site 768492012876 citrylCoA binding site [chemical binding]; other site 768492012877 oxalacetate/citrate binding site [chemical binding]; other site 768492012878 coenzyme A binding site [chemical binding]; other site 768492012879 catalytic triad [active] 768492012880 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 768492012881 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 768492012882 tetramer interface [polypeptide binding]; other site 768492012883 active site 768492012884 Mg2+/Mn2+ binding site [ion binding]; other site 768492012885 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 768492012886 Propionate catabolism activator; Region: PrpR_N; pfam06506 768492012887 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492012888 Walker A motif; other site 768492012889 ATP binding site [chemical binding]; other site 768492012890 Walker B motif; other site 768492012891 arginine finger; other site 768492012892 Helix-turn-helix domains; Region: HTH; cl00088 768492012893 ornithine decarboxylase; Provisional; Region: PRK13578 768492012894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 768492012895 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 768492012896 homodimer interface [polypeptide binding]; other site 768492012897 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492012898 catalytic residue [active] 768492012899 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 768492012900 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768492012901 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 768492012902 transcriptional regulator; Provisional; Region: PRK10632 768492012903 Helix-turn-helix domains; Region: HTH; cl00088 768492012904 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492012905 dimerization interface [polypeptide binding]; other site 768492012906 Helix-turn-helix domains; Region: HTH; cl00088 768492012907 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768492012908 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 768492012909 classical (c) SDRs; Region: SDR_c; cd05233 768492012910 NAD(P) binding site [chemical binding]; other site 768492012911 active site 768492012912 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 768492012913 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 768492012914 Flavin Reductases; Region: FlaRed; cl00801 768492012915 This alignment model represents the N-terminal rieske domain of the oxygenase alpha subunit of aminopyrrolnitrin oxygenase (PrnD). PrnD is a novel Rieske N-oxygenase that catalyzes the final step in the pyrrolnitrin biosynthetic pathway, the oxidation...; Region: Rieske_RO_Alpha_PrnD; cd03537 768492012916 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 768492012917 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 768492012918 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492012919 Domain of unknown function (DUF1864); Region: DUF1864; pfam08933 768492012920 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492012921 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 768492012922 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768492012923 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 768492012924 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 768492012925 ABC-2 type transporter; Region: ABC2_membrane; cl11417 768492012926 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 768492012927 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492012928 Walker A/P-loop; other site 768492012929 ATP binding site [chemical binding]; other site 768492012930 Q-loop/lid; other site 768492012931 ABC transporter signature motif; other site 768492012932 Walker B; other site 768492012933 D-loop; other site 768492012934 H-loop/switch region; other site 768492012935 Condensation domain; Region: Condensation; pfam00668 768492012936 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 768492012937 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 768492012938 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 768492012939 active site 768492012940 Acyl transferase domain; Region: Acyl_transf_1; cl08282 768492012941 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 768492012942 putative NADP binding site [chemical binding]; other site 768492012943 active site 768492012944 Phosphopantetheine attachment site; Region: PP-binding; cl09936 768492012945 peptide synthase; Provisional; Region: PRK12467 768492012946 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 768492012947 AMP-binding enzyme; Region: AMP-binding; cl15778 768492012948 AMP-binding enzyme; Region: AMP-binding; cl15778 768492012949 Phosphopantetheine attachment site; Region: PP-binding; cl09936 768492012950 peptide synthase; Provisional; Region: PRK12467 768492012951 AMP-binding enzyme; Region: AMP-binding; cl15778 768492012952 AMP-binding enzyme; Region: AMP-binding; cl15778 768492012953 Phosphopantetheine attachment site; Region: PP-binding; cl09936 768492012954 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 768492012955 AMP-binding enzyme; Region: AMP-binding; cl15778 768492012956 Phosphopantetheine attachment site; Region: PP-binding; cl09936 768492012957 peptide synthase; Provisional; Region: PRK12467 768492012958 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 768492012959 AMP-binding enzyme; Region: AMP-binding; cl15778 768492012960 Phosphopantetheine attachment site; Region: PP-binding; cl09936 768492012961 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 768492012962 AMP-binding enzyme; Region: AMP-binding; cl15778 768492012963 Phosphopantetheine attachment site; Region: PP-binding; cl09936 768492012964 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 768492012965 AMP-binding enzyme; Region: AMP-binding; cl15778 768492012966 Phosphopantetheine attachment site; Region: PP-binding; cl09936 768492012967 Predicted amidohydrolase [General function prediction only]; Region: COG0388 768492012968 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 768492012969 putative active site [active] 768492012970 catalytic triad [active] 768492012971 dimer interface [polypeptide binding]; other site 768492012972 multimer interface [polypeptide binding]; other site 768492012973 thioester reductase domain; Region: Thioester-redct; TIGR01746 768492012974 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 768492012975 putative NAD(P) binding site [chemical binding]; other site 768492012976 active site 768492012977 putative substrate binding site [chemical binding]; other site 768492012978 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 768492012979 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492012980 NAD(P) binding site [chemical binding]; other site 768492012981 active site 768492012982 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 768492012983 FMN binding site [chemical binding]; other site 768492012984 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 768492012985 substrate binding site [chemical binding]; other site 768492012986 putative catalytic residue [active] 768492012987 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768492012988 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 768492012989 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492012990 catalytic residue [active] 768492012991 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 768492012992 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 768492012993 active site 768492012994 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 768492012995 active site 768492012996 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 768492012997 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 768492012998 active site 2 [active] 768492012999 active site 1 [active] 768492013000 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 768492013001 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 768492013002 active site 768492013003 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 768492013004 Acyl transferase domain; Region: Acyl_transf_1; cl08282 768492013005 polyketide-type polyunsaturated fatty acid synthase PfaA; Region: omega_3_PfaA; TIGR02813 768492013006 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 768492013007 putative NADP binding site [chemical binding]; other site 768492013008 active site 768492013009 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 768492013010 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768492013011 FtsX-like permease family; Region: FtsX; cl15850 768492013012 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768492013013 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 768492013014 Walker A/P-loop; other site 768492013015 ATP binding site [chemical binding]; other site 768492013016 Q-loop/lid; other site 768492013017 ABC transporter signature motif; other site 768492013018 Walker B; other site 768492013019 D-loop; other site 768492013020 H-loop/switch region; other site 768492013021 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 768492013022 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 768492013023 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 768492013024 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 768492013025 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 768492013026 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 768492013027 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768492013028 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492013029 catalytic residue [active] 768492013030 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 768492013031 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768492013032 PYR/PP interface [polypeptide binding]; other site 768492013033 dimer interface [polypeptide binding]; other site 768492013034 TPP binding site [chemical binding]; other site 768492013035 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 768492013036 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 768492013037 TPP-binding site [chemical binding]; other site 768492013038 dimer interface [polypeptide binding]; other site 768492013039 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 768492013040 putative active site pocket [active] 768492013041 dimerization interface [polypeptide binding]; other site 768492013042 putative catalytic residue [active] 768492013043 Phosphopantetheine attachment site; Region: PP-binding; cl09936 768492013044 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 768492013045 glutathionine S-transferase; Provisional; Region: PRK10542 768492013046 C-terminal domain interface [polypeptide binding]; other site 768492013047 GSH binding site (G-site) [chemical binding]; other site 768492013048 dimer interface [polypeptide binding]; other site 768492013049 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 768492013050 dimer interface [polypeptide binding]; other site 768492013051 N-terminal domain interface [polypeptide binding]; other site 768492013052 substrate binding pocket (H-site) [chemical binding]; other site 768492013053 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 768492013054 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 768492013055 homodimer interface [polypeptide binding]; other site 768492013056 substrate-cofactor binding pocket; other site 768492013057 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492013058 catalytic residue [active] 768492013059 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 768492013060 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 768492013061 active site pocket [active] 768492013062 Benzoate membrane transport protein; Region: BenE; pfam03594 768492013063 benzoate transporter; Region: benE; TIGR00843 768492013064 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 768492013065 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 768492013066 active site 768492013067 non-prolyl cis peptide bond; other site 768492013068 cystathionine beta-lyase; Provisional; Region: PRK05967 768492013069 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768492013070 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492013071 catalytic residue [active] 768492013072 Dehydratase family; Region: ILVD_EDD; cl00340 768492013073 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 768492013074 Helix-turn-helix domains; Region: HTH; cl00088 768492013075 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492013076 dimerization interface [polypeptide binding]; other site 768492013077 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 768492013078 GAF domain; Region: GAF; cl15785 768492013079 GAF domain; Region: GAF; cl15785 768492013080 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492013081 Walker A motif; other site 768492013082 ATP binding site [chemical binding]; other site 768492013083 Walker B motif; other site 768492013084 arginine finger; other site 768492013085 Helix-turn-helix domains; Region: HTH; cl00088 768492013086 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 768492013087 dimerization interface [polypeptide binding]; other site 768492013088 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 768492013089 ATP binding site [chemical binding]; other site 768492013090 Hydrogenase formation hypA family; Region: HypD; cl12072 768492013091 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 768492013092 HupF/HypC family; Region: HupF_HypC; cl00394 768492013093 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492013094 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 768492013095 hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418 768492013096 Transcriptional repressor of hyc and hyp operons; Region: HycA_repressor; cl08095 768492013097 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 768492013098 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 768492013099 hydrogenase membrane subunit; Validated; Region: PRK08667 768492013100 NADH dehydrogenase; Region: NADHdh; cl00469 768492013101 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16919 768492013102 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 768492013103 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 768492013104 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 768492013105 4Fe-4S binding domain; Region: Fer4; cl02805 768492013106 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 768492013107 Formate hydrogenlyase maturation protein HycH; Region: HycH; cl06472 768492013108 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 768492013109 nickel binding site [ion binding]; other site 768492013110 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 768492013111 4Fe-4S binding domain; Region: Fer4; cl02805 768492013112 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 768492013113 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 768492013114 [4Fe-4S] binding site [ion binding]; other site 768492013115 molybdopterin cofactor binding site; other site 768492013116 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 768492013117 molybdopterin cofactor binding site; other site 768492013118 Acylphosphatase; Region: Acylphosphatase; cl00551 768492013119 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 768492013120 HypF finger; Region: zf-HYPF; pfam07503 768492013121 HypF finger; Region: zf-HYPF; pfam07503 768492013122 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 768492013123 High-affinity nickel-transport protein; Region: NicO; cl00964 768492013124 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492013125 Coenzyme A binding pocket [chemical binding]; other site 768492013126 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 768492013127 PAS fold; Region: PAS_4; pfam08448 768492013128 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492013129 DNA binding residues [nucleotide binding] 768492013130 dimerization interface [polypeptide binding]; other site 768492013131 Sodium:solute symporter family; Region: SSF; cl00456 768492013132 NIPSNAP; Region: NIPSNAP; pfam07978 768492013133 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 768492013134 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 768492013135 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 768492013136 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 768492013137 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 768492013138 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 768492013139 Phosphoesterase family; Region: Phosphoesterase; cl15450 768492013140 Domain of unknown function (DUF756); Region: DUF756; pfam05506 768492013141 Domain of unknown function (DUF756); Region: DUF756; pfam05506 768492013142 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 768492013143 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 768492013144 PAS fold; Region: PAS; pfam00989 768492013145 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 768492013146 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 768492013147 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 768492013148 Protein of unknown function, DUF596; Region: DUF596; cl10492 768492013149 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768492013150 anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154 768492013151 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 768492013152 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 768492013153 haemagglutination activity domain; Region: Haemagg_act; cl05436 768492013154 adhesin HecA family 20-residue repeat (two copies); Region: fil_hemag_20aa; TIGR01731 768492013155 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 768492013156 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768492013157 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768492013158 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768492013159 RTX toxin acyltransferase family; Region: HlyC; cl01131 768492013160 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 768492013161 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 768492013162 Surface antigen; Region: Bac_surface_Ag; cl03097 768492013163 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768492013164 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 768492013165 putative substrate binding site [chemical binding]; other site 768492013166 putative ATP binding site [chemical binding]; other site 768492013167 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768492013168 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 768492013169 active site turn [active] 768492013170 phosphorylation site [posttranslational modification] 768492013171 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 768492013172 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 768492013173 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 768492013174 substrate binding [chemical binding]; other site 768492013175 active site 768492013176 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 768492013177 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 768492013178 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492013179 DNA binding site [nucleotide binding] 768492013180 domain linker motif; other site 768492013181 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 768492013182 dimerization interface [polypeptide binding]; other site 768492013183 ligand binding site [chemical binding]; other site 768492013184 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 768492013185 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 768492013186 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 768492013187 shikimate binding site; other site 768492013188 NAD(P) binding site [chemical binding]; other site 768492013189 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 768492013190 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 768492013191 cystathionine beta-lyase; Provisional; Region: PRK08114 768492013192 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 768492013193 homodimer interface [polypeptide binding]; other site 768492013194 substrate-cofactor binding pocket; other site 768492013195 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492013196 catalytic residue [active] 768492013197 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 768492013198 transcriptional regulator; Provisional; Region: PRK10632 768492013199 Helix-turn-helix domains; Region: HTH; cl00088 768492013200 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 768492013201 putative effector binding pocket; other site 768492013202 putative dimerization interface [polypeptide binding]; other site 768492013203 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 768492013204 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 768492013205 putative NAD(P) binding site [chemical binding]; other site 768492013206 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 768492013207 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768492013208 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492013209 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492013210 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 768492013211 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 768492013212 dimer interface [polypeptide binding]; other site 768492013213 active site 768492013214 metal binding site [ion binding]; metal-binding site 768492013215 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768492013216 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768492013217 active site 768492013218 catalytic tetrad [active] 768492013219 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 768492013220 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 768492013221 methionine cluster; other site 768492013222 active site 768492013223 phosphorylation site [posttranslational modification] 768492013224 metal binding site [ion binding]; metal-binding site 768492013225 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 768492013226 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 768492013227 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 768492013228 active site 768492013229 P-loop; other site 768492013230 phosphorylation site [posttranslational modification] 768492013231 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 768492013232 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 768492013233 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768492013234 catalytic residue [active] 768492013235 hypothetical protein; Provisional; Region: PRK01254 768492013236 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 768492013237 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 768492013238 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 768492013239 substrate binding site [chemical binding]; other site 768492013240 ATP binding site [chemical binding]; other site 768492013241 nucleoside transporter; Region: 2A0110; TIGR00889 768492013242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492013243 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 768492013244 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 768492013245 Helix-turn-helix domains; Region: HTH; cl00088 768492013246 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 768492013247 putative dimerization interface [polypeptide binding]; other site 768492013248 putative substrate binding pocket [chemical binding]; other site 768492013249 FtsI repressor; Provisional; Region: PRK10883 768492013250 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 768492013251 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 768492013252 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 768492013253 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 768492013254 putative acyl-acceptor binding pocket; other site 768492013255 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 768492013256 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 768492013257 CAP-like domain; other site 768492013258 active site 768492013259 primary dimer interface [polypeptide binding]; other site 768492013260 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 768492013261 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 768492013262 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492013263 Helix-turn-helix domains; Region: HTH; cl00088 768492013264 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492013265 dimerization interface [polypeptide binding]; other site 768492013266 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 768492013267 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492013268 ATP binding site [chemical binding]; other site 768492013269 Mg2+ binding site [ion binding]; other site 768492013270 G-X-G motif; other site 768492013271 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 768492013272 anchoring element; other site 768492013273 dimer interface [polypeptide binding]; other site 768492013274 ATP binding site [chemical binding]; other site 768492013275 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 768492013276 active site 768492013277 metal binding site [ion binding]; metal-binding site 768492013278 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 768492013279 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 768492013280 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 768492013281 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 768492013282 active site 768492013283 metal binding site [ion binding]; metal-binding site 768492013284 hexamer interface [polypeptide binding]; other site 768492013285 Protein of unknown function (DUF1249); Region: DUF1249; cl01223 768492013286 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 768492013287 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 768492013288 dimer interface [polypeptide binding]; other site 768492013289 ADP-ribose binding site [chemical binding]; other site 768492013290 active site 768492013291 nudix motif; other site 768492013292 metal binding site [ion binding]; metal-binding site 768492013293 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 768492013294 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 768492013295 GAF domain; Region: GAF; cl15785 768492013296 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 768492013297 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492013298 Walker A motif; other site 768492013299 ATP binding site [chemical binding]; other site 768492013300 Walker B motif; other site 768492013301 arginine finger; other site 768492013302 Helix-turn-helix domains; Region: HTH; cl00088 768492013303 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 768492013304 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 768492013305 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 768492013306 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 768492013307 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 768492013308 DAK2 domain; Region: Dak2; cl03685 768492013309 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 768492013310 Dak1 domain; Region: Dak1; pfam02733 768492013311 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 768492013312 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 768492013313 dimer interface [polypeptide binding]; other site 768492013314 active site 768492013315 metal binding site [ion binding]; metal-binding site 768492013316 Protein of unknown function (DUF1190); Region: DUF1190; cl10031 768492013317 Circularly permuted ATP-grasp type 2; Region: CP_ATPgrasp_2; cl00503 768492013318 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 768492013319 putative active site [active] 768492013320 metal binding site [ion binding]; metal-binding site 768492013321 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 768492013322 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 768492013323 dimer interface [polypeptide binding]; other site 768492013324 Alkaline phosphatase homologues; Region: alkPPc; smart00098 768492013325 active site 768492013326 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 768492013327 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 768492013328 Membrane fusogenic activity; Region: BMFP; cl01115 768492013329 putative transporter; Provisional; Region: PRK11021 768492013330 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 768492013331 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 768492013332 putative ribose interaction site [chemical binding]; other site 768492013333 putative ADP binding site [chemical binding]; other site 768492013334 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768492013335 active site 768492013336 nucleotide binding site [chemical binding]; other site 768492013337 HIGH motif; other site 768492013338 KMSKS motif; other site 768492013339 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 768492013340 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 768492013341 metal binding triad; other site 768492013342 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 768492013343 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 768492013344 metal binding triad; other site 768492013345 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 768492013346 Uncharacterized conserved protein [Function unknown]; Region: COG3025 768492013347 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 768492013348 putative active site [active] 768492013349 putative metal binding residues [ion binding]; other site 768492013350 signature motif; other site 768492013351 putative triphosphate binding site [ion binding]; other site 768492013352 CHAD domain; Region: CHAD; cl10506 768492013353 SH3 domain-containing protein; Provisional; Region: PRK10884 768492013354 Bacterial SH3 domain; Region: SH3_3; cl02551 768492013355 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 768492013356 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 768492013357 active site 768492013358 NTP binding site [chemical binding]; other site 768492013359 metal binding triad [ion binding]; metal-binding site 768492013360 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 768492013361 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 768492013362 Bacitracin resistance protein BacA; Region: BacA; cl00858 768492013363 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 768492013364 homooctamer interface [polypeptide binding]; other site 768492013365 active site 768492013366 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 768492013367 UGMP family protein; Validated; Region: PRK09604 768492013368 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 768492013369 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 768492013370 DNA primase; Validated; Region: dnaG; PRK05667 768492013371 CHC2 zinc finger; Region: zf-CHC2; cl15369 768492013372 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 768492013373 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 768492013374 active site 768492013375 metal binding site [ion binding]; metal-binding site 768492013376 interdomain interaction site; other site 768492013377 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 768492013378 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 768492013379 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 768492013380 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 768492013381 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 768492013382 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 768492013383 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768492013384 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 768492013385 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768492013386 DNA binding residues [nucleotide binding] 768492013387 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 768492013388 active site 768492013389 SUMO-1 interface [polypeptide binding]; other site 768492013390 HPP family; Region: HPP; pfam04982 768492013391 glutathione S-transferase; Provisional; Region: PRK15113 768492013392 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 768492013393 C-terminal domain interface [polypeptide binding]; other site 768492013394 GSH binding site (G-site) [chemical binding]; other site 768492013395 dimer interface [polypeptide binding]; other site 768492013396 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 768492013397 N-terminal domain interface [polypeptide binding]; other site 768492013398 putative dimer interface [polypeptide binding]; other site 768492013399 putative substrate binding pocket (H-site) [chemical binding]; other site 768492013400 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 768492013401 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 768492013402 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 768492013403 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 768492013404 tetramerization interface [polypeptide binding]; other site 768492013405 NAD(P) binding site [chemical binding]; other site 768492013406 catalytic residues [active] 768492013407 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 768492013408 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768492013409 inhibitor-cofactor binding pocket; inhibition site 768492013410 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492013411 catalytic residue [active] 768492013412 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768492013413 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492013414 DNA-binding site [nucleotide binding]; DNA binding site 768492013415 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492013416 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492013417 homodimer interface [polypeptide binding]; other site 768492013418 catalytic residue [active] 768492013419 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 768492013420 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492013421 Walker A/P-loop; other site 768492013422 ATP binding site [chemical binding]; other site 768492013423 Q-loop/lid; other site 768492013424 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 768492013425 ABC transporter signature motif; other site 768492013426 Walker B; other site 768492013427 D-loop; other site 768492013428 ABC transporter; Region: ABC_tran_2; pfam12848 768492013429 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 768492013430 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 768492013431 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 768492013432 active site 768492013433 FMN binding site [chemical binding]; other site 768492013434 2,4-decadienoyl-CoA binding site; other site 768492013435 catalytic residue [active] 768492013436 4Fe-4S cluster binding site [ion binding]; other site 768492013437 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492013438 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 768492013439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 768492013440 Protein of unknown function DUF45; Region: DUF45; cl00636 768492013441 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768492013442 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492013443 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 768492013444 catalytic triad [active] 768492013445 Integral membrane protein TerC family; Region: TerC; cl10468 768492013446 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 768492013447 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 768492013448 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 768492013449 SAF domain; Region: SAF; cl00555 768492013450 Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721 768492013451 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 768492013452 Glucuronate isomerase; Region: UxaC; cl00829 768492013453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492013454 D-galactonate transporter; Region: 2A0114; TIGR00893 768492013455 putative substrate translocation pore; other site 768492013456 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 768492013457 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492013458 DNA-binding site [nucleotide binding]; DNA binding site 768492013459 FCD domain; Region: FCD; cl11656 768492013460 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 768492013461 SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136 768492013462 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 768492013463 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 768492013464 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 768492013465 YqjK-like protein; Region: YqjK; pfam13997 768492013466 DoxX; Region: DoxX; cl00976 768492013467 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 768492013468 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 768492013469 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 768492013470 putative dimer interface [polypeptide binding]; other site 768492013471 N-terminal domain interface [polypeptide binding]; other site 768492013472 putative substrate binding pocket (H-site) [chemical binding]; other site 768492013473 Helix-turn-helix domains; Region: HTH; cl00088 768492013474 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 768492013475 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492013476 dimerization interface [polypeptide binding]; other site 768492013477 Cupin domain; Region: Cupin_2; cl09118 768492013478 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 768492013479 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 768492013480 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 768492013481 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 768492013482 putative ligand binding site [chemical binding]; other site 768492013483 Restriction endonuclease; Region: Mrr_cat; cl00516 768492013484 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 768492013485 dimer interface [polypeptide binding]; other site 768492013486 active site 768492013487 outer membrane lipoprotein; Provisional; Region: PRK11023 768492013488 BON domain; Region: BON; cl02771 768492013489 Transglycosylase; Region: Transgly; cl07896 768492013490 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 768492013491 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 768492013492 conserved cys residue [active] 768492013493 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 768492013494 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768492013495 putative active site [active] 768492013496 heme pocket [chemical binding]; other site 768492013497 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492013498 dimer interface [polypeptide binding]; other site 768492013499 phosphorylation site [posttranslational modification] 768492013500 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492013501 ATP binding site [chemical binding]; other site 768492013502 Mg2+ binding site [ion binding]; other site 768492013503 G-X-G motif; other site 768492013504 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492013505 active site 768492013506 phosphorylation site [posttranslational modification] 768492013507 intermolecular recognition site; other site 768492013508 dimerization interface [polypeptide binding]; other site 768492013509 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 768492013510 putative binding surface; other site 768492013511 active site 768492013512 radical SAM protein, TIGR01212 family; Region: TIGR01212 768492013513 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768492013514 FeS/SAM binding site; other site 768492013515 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 768492013516 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 768492013517 active site 768492013518 dimer interface [polypeptide binding]; other site 768492013519 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 768492013520 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 768492013521 active site 768492013522 FMN binding site [chemical binding]; other site 768492013523 substrate binding site [chemical binding]; other site 768492013524 3Fe-4S cluster binding site [ion binding]; other site 768492013525 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 768492013526 domain interface; other site 768492013527 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 768492013528 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768492013529 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492013530 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768492013531 Stringent starvation protein B; Region: SspB; cl01120 768492013532 stringent starvation protein A; Provisional; Region: sspA; PRK09481 768492013533 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 768492013534 C-terminal domain interface [polypeptide binding]; other site 768492013535 putative GSH binding site (G-site) [chemical binding]; other site 768492013536 dimer interface [polypeptide binding]; other site 768492013537 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 768492013538 dimer interface [polypeptide binding]; other site 768492013539 N-terminal domain interface [polypeptide binding]; other site 768492013540 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 768492013541 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 768492013542 23S rRNA interface [nucleotide binding]; other site 768492013543 L3 interface [polypeptide binding]; other site 768492013544 Predicted ATPase [General function prediction only]; Region: COG1485 768492013545 Protein of unknown function (DUF1043); Region: DUF1043; cl11473 768492013546 serine endoprotease; Provisional; Region: PRK10139 768492013547 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 768492013548 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 768492013549 protein binding site [polypeptide binding]; other site 768492013550 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 768492013551 serine endoprotease; Provisional; Region: PRK10898 768492013552 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 768492013553 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 768492013554 protein binding site [polypeptide binding]; other site 768492013555 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 768492013556 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 768492013557 hinge; other site 768492013558 active site 768492013559 BolA-like protein; Region: BolA; cl00386 768492013560 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 768492013561 anti sigma factor interaction site; other site 768492013562 regulatory phosphorylation site [posttranslational modification]; other site 768492013563 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 768492013564 mce related protein; Region: MCE; pfam02470 768492013565 Permease; Region: Permease; cl00510 768492013566 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 768492013567 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 768492013568 Walker A/P-loop; other site 768492013569 ATP binding site [chemical binding]; other site 768492013570 Q-loop/lid; other site 768492013571 ABC transporter signature motif; other site 768492013572 Walker B; other site 768492013573 D-loop; other site 768492013574 H-loop/switch region; other site 768492013575 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 768492013576 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 768492013577 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 768492013578 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 768492013579 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 768492013580 putative active site [active] 768492013581 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 768492013582 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 768492013583 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 768492013584 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 768492013585 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 768492013586 OstA-like protein; Region: OstA; cl00844 768492013587 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 768492013588 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 768492013589 Walker A/P-loop; other site 768492013590 ATP binding site [chemical binding]; other site 768492013591 Q-loop/lid; other site 768492013592 ABC transporter signature motif; other site 768492013593 Walker B; other site 768492013594 D-loop; other site 768492013595 H-loop/switch region; other site 768492013596 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 768492013597 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 768492013598 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 768492013599 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 768492013600 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 768492013601 30S subunit binding site; other site 768492013602 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 768492013603 active site 768492013604 phosphorylation site [posttranslational modification] 768492013605 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 768492013606 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 768492013607 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 768492013608 dimerization domain swap beta strand [polypeptide binding]; other site 768492013609 regulatory protein interface [polypeptide binding]; other site 768492013610 active site 768492013611 regulatory phosphorylation site [posttranslational modification]; other site 768492013612 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 768492013613 Helix-turn-helix domains; Region: HTH; cl00088 768492013614 Helix-turn-helix domains; Region: HTH; cl00088 768492013615 PRD domain; Region: PRD; cl15445 768492013616 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 768492013617 active site 768492013618 P-loop; other site 768492013619 phosphorylation site [posttranslational modification] 768492013620 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 768492013621 active site 768492013622 phosphorylation site [posttranslational modification] 768492013623 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 768492013624 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 768492013625 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768492013626 dihydroorotase; Provisional; Region: PRK09237 768492013627 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 768492013628 active site 768492013629 Domain of unknown function (DUF4310); Region: DUF4310; cl11918 768492013630 Domain of unknown function (DUF4311); Region: DUF4311; cl11919 768492013631 Domain of unknown function (DUF4312); Region: DUF4312; cl11917 768492013632 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; cl11916 768492013633 PRD domain; Region: PRD; cl15445 768492013634 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 768492013635 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 768492013636 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 768492013637 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 768492013638 active site 768492013639 cosubstrate binding site; other site 768492013640 substrate binding site [chemical binding]; other site 768492013641 catalytic site [active] 768492013642 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492013643 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 768492013644 Cupin domain; Region: Cupin_2; cl09118 768492013645 Helix-turn-helix domain; Region: HTH_18; pfam12833 768492013646 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492013647 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492013648 Cytochrome b562; Region: Cytochrom_B562; cl01546 768492013649 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 768492013650 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 768492013651 Protein of unknown function (DUF615); Region: DUF615; cl01147 768492013652 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 768492013653 RNAase interaction site [polypeptide binding]; other site 768492013654 Barnase, a member of the family of homologous microbial ribonucleases, catalyses the cleavage of single-stranded RNA via a two-step mechanism thought to be similar to that of pancreatic ribonuclease. The mechanism involves a transesterification to give a...; Region: barnase; cd00933 768492013655 active site 768492013656 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 768492013657 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 768492013658 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 768492013659 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 768492013660 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 768492013661 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 768492013662 transcriptional regulator; Provisional; Region: PRK10632 768492013663 Helix-turn-helix domains; Region: HTH; cl00088 768492013664 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492013665 putative effector binding pocket; other site 768492013666 dimerization interface [polypeptide binding]; other site 768492013667 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 768492013668 active site 768492013669 tetramer interface [polypeptide binding]; other site 768492013670 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 768492013671 haemagglutination activity domain; Region: Haemagg_act; cl05436 768492013672 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768492013673 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768492013674 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768492013675 MafB19-like deaminase; Region: MafB19-deam; pfam14437 768492013676 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 768492013677 Surface antigen; Region: Bac_surface_Ag; cl03097 768492013678 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 768492013679 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 768492013680 Predicted amidohydrolase [General function prediction only]; Region: COG0388 768492013681 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 768492013682 putative active site [active] 768492013683 catalytic triad [active] 768492013684 dimer interface [polypeptide binding]; other site 768492013685 hypothetical protein; Provisional; Region: PRK10899 768492013686 AsmA-like C-terminal region; Region: AsmA_2; cl15864 768492013687 ribonuclease G; Provisional; Region: PRK11712 768492013688 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 768492013689 homodimer interface [polypeptide binding]; other site 768492013690 oligonucleotide binding site [chemical binding]; other site 768492013691 Maf-like protein; Region: Maf; pfam02545 768492013692 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 768492013693 active site 768492013694 dimer interface [polypeptide binding]; other site 768492013695 rod shape-determining protein MreD; Region: MreD; cl01087 768492013696 rod shape-determining protein MreC; Region: mreC; TIGR00219 768492013697 rod shape-determining protein MreC; Region: MreC; pfam04085 768492013698 rod shape-determining protein MreB; Provisional; Region: PRK13927 768492013699 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 768492013700 ATP binding site [chemical binding]; other site 768492013701 profilin binding site; other site 768492013702 regulatory protein CsrD; Provisional; Region: PRK11059 768492013703 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768492013704 metal binding site [ion binding]; metal-binding site 768492013705 active site 768492013706 I-site; other site 768492013707 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768492013708 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 768492013709 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 768492013710 NADP binding site [chemical binding]; other site 768492013711 dimer interface [polypeptide binding]; other site 768492013712 TMAO/DMSO reductase; Reviewed; Region: PRK05363 768492013713 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 768492013714 Moco binding site; other site 768492013715 metal coordination site [ion binding]; other site 768492013716 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 768492013717 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 768492013718 active site 768492013719 trimer interface [polypeptide binding]; other site 768492013720 dimer interface [polypeptide binding]; other site 768492013721 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 768492013722 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 768492013723 carboxyltransferase (CT) interaction site; other site 768492013724 biotinylation site [posttranslational modification]; other site 768492013725 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 768492013726 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 768492013727 ATP-grasp domain; Region: ATP-grasp_4; cl03087 768492013728 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 768492013729 Protein of unknown function (DUF997); Region: DUF997; cl01614 768492013730 Sodium:solute symporter family; Region: SSF; cl00456 768492013731 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 768492013732 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 768492013733 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 768492013734 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 768492013735 active site 768492013736 zinc binding site [ion binding]; other site 768492013737 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 768492013738 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 768492013739 FMN binding site [chemical binding]; other site 768492013740 active site 768492013741 catalytic residues [active] 768492013742 substrate binding site [chemical binding]; other site 768492013743 Helix-turn-helix domains; Region: HTH; cl00088 768492013744 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 768492013745 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 768492013746 putative acyl-acceptor binding pocket; other site 768492013747 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 768492013748 conserved cys residue [active] 768492013749 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 768492013750 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 768492013751 AMP-binding enzyme; Region: AMP-binding; cl15778 768492013752 Phosphopantetheine attachment site; Region: PP-binding; cl09936 768492013753 LrgB-like family; Region: LrgB; cl00596 768492013754 LrgA family; Region: LrgA; cl00608 768492013755 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492013756 Helix-turn-helix domains; Region: HTH; cl00088 768492013757 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 768492013758 putative dimerization interface [polypeptide binding]; other site 768492013759 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 768492013760 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 768492013761 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 768492013762 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768492013763 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 768492013764 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 768492013765 putative C-terminal domain interface [polypeptide binding]; other site 768492013766 putative GSH binding site (G-site) [chemical binding]; other site 768492013767 putative dimer interface [polypeptide binding]; other site 768492013768 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 768492013769 putative N-terminal domain interface [polypeptide binding]; other site 768492013770 putative dimer interface [polypeptide binding]; other site 768492013771 putative substrate binding pocket (H-site) [chemical binding]; other site 768492013772 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 768492013773 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492013774 Helix-turn-helix domains; Region: HTH; cl00088 768492013775 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492013776 putative effector binding pocket; other site 768492013777 dimerization interface [polypeptide binding]; other site 768492013778 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 768492013779 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492013780 NAD(P) binding site [chemical binding]; other site 768492013781 active site 768492013782 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 768492013783 dimer interface [polypeptide binding]; other site 768492013784 ssDNA binding site [nucleotide binding]; other site 768492013785 tetramer (dimer of dimers) interface [polypeptide binding]; other site 768492013786 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 768492013787 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 768492013788 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 768492013789 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 768492013790 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 768492013791 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 768492013792 putative NAD(P) binding site [chemical binding]; other site 768492013793 putative substrate binding site [chemical binding]; other site 768492013794 catalytic Zn binding site [ion binding]; other site 768492013795 structural Zn binding site [ion binding]; other site 768492013796 dimer interface [polypeptide binding]; other site 768492013797 maltose O-acetyltransferase; Provisional; Region: PRK10092 768492013798 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 768492013799 active site 768492013800 substrate binding site [chemical binding]; other site 768492013801 trimer interface [polypeptide binding]; other site 768492013802 CoA binding site [chemical binding]; other site 768492013803 Protein of unknown function (DUF419); Region: DUF419; cl15265 768492013804 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 768492013805 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 768492013806 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492013807 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492013808 homodimer interface [polypeptide binding]; other site 768492013809 catalytic residue [active] 768492013810 Uncharacterized conserved protein [Function unknown]; Region: COG1284 768492013811 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 768492013812 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768492013813 Helix-turn-helix domains; Region: HTH; cl00088 768492013814 Helix-turn-helix domains; Region: HTH; cl00088 768492013815 aromatic amino acid transporter; Provisional; Region: PRK10238 768492013816 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492013817 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768492013818 substrate binding pocket [chemical binding]; other site 768492013819 membrane-bound complex binding site; other site 768492013820 hinge residues; other site 768492013821 alanine racemase; Reviewed; Region: alr; PRK00053 768492013822 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 768492013823 active site 768492013824 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768492013825 substrate binding site [chemical binding]; other site 768492013826 catalytic residues [active] 768492013827 dimer interface [polypeptide binding]; other site 768492013828 replicative DNA helicase; Provisional; Region: PRK08006 768492013829 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 768492013830 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 768492013831 Walker A motif; other site 768492013832 ATP binding site [chemical binding]; other site 768492013833 Walker B motif; other site 768492013834 DNA binding loops [nucleotide binding] 768492013835 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 768492013836 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 768492013837 NADP binding site [chemical binding]; other site 768492013838 dimer interface [polypeptide binding]; other site 768492013839 Phage shock protein G (Phageshock_PspG); Region: Phageshock_PspG; cl11511 768492013840 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 768492013841 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 768492013842 FMN binding site [chemical binding]; other site 768492013843 active site 768492013844 catalytic residues [active] 768492013845 substrate binding site [chemical binding]; other site 768492013846 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768492013847 binding surface 768492013848 TPR motif; other site 768492013849 Tetratricopeptide repeat; Region: TPR_16; pfam13432 768492013850 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768492013851 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768492013852 DNA binding residues [nucleotide binding] 768492013853 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 768492013854 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 768492013855 metal binding site 2 [ion binding]; metal-binding site 768492013856 putative DNA binding helix; other site 768492013857 metal binding site 1 [ion binding]; metal-binding site 768492013858 dimer interface [polypeptide binding]; other site 768492013859 structural Zn2+ binding site [ion binding]; other site 768492013860 CsbD-like; Region: CsbD; cl15799 768492013861 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 768492013862 MatE; Region: MatE; cl10513 768492013863 MatE; Region: MatE; cl10513 768492013864 LexA repressor; Validated; Region: PRK00215 768492013865 Helix-turn-helix domains; Region: HTH; cl00088 768492013866 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 768492013867 Catalytic site [active] 768492013868 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 768492013869 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 768492013870 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 768492013871 putative acyl-acceptor binding pocket; other site 768492013872 UbiA prenyltransferase family; Region: UbiA; cl00337 768492013873 UTRA domain; Region: UTRA; cl01230 768492013874 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 768492013875 active site 768492013876 Maltose operon periplasmic protein precursor (MalM); Region: MalM; cl11647 768492013877 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 768492013878 trimer interface; other site 768492013879 sugar binding site [chemical binding]; other site 768492013880 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 768492013881 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 768492013882 Walker A/P-loop; other site 768492013883 ATP binding site [chemical binding]; other site 768492013884 Q-loop/lid; other site 768492013885 ABC transporter signature motif; other site 768492013886 Walker B; other site 768492013887 D-loop; other site 768492013888 H-loop/switch region; other site 768492013889 TOBE domain; Region: TOBE_2; cl01440 768492013890 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 768492013891 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 768492013892 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492013893 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492013894 dimer interface [polypeptide binding]; other site 768492013895 conserved gate region; other site 768492013896 putative PBP binding loops; other site 768492013897 ABC-ATPase subunit interface; other site 768492013898 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 768492013899 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492013900 dimer interface [polypeptide binding]; other site 768492013901 conserved gate region; other site 768492013902 putative PBP binding loops; other site 768492013903 ABC-ATPase subunit interface; other site 768492013904 Phosphate-starvation-inducible E; Region: PsiE; cl01264 768492013905 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 768492013906 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 768492013907 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 768492013908 active site 768492013909 dimer interface [polypeptide binding]; other site 768492013910 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 768492013911 dimer interface [polypeptide binding]; other site 768492013912 active site 768492013913 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 768492013914 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 768492013915 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492013916 aspartate kinase III; Validated; Region: PRK09084 768492013917 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 768492013918 nucleotide binding site [chemical binding]; other site 768492013919 substrate binding site [chemical binding]; other site 768492013920 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 768492013921 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 768492013922 dimer interface [polypeptide binding]; other site 768492013923 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 768492013924 Membrane transport protein; Region: Mem_trans; cl09117 768492013925 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 768492013926 Surface antigen; Region: Bac_surface_Ag; cl03097 768492013927 haemagglutination activity domain; Region: Haemagg_act; cl05436 768492013928 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768492013929 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768492013930 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768492013931 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768492013932 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768492013933 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 768492013934 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 768492013935 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 768492013936 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492013937 Walker A/P-loop; other site 768492013938 ATP binding site [chemical binding]; other site 768492013939 Q-loop/lid; other site 768492013940 ABC transporter signature motif; other site 768492013941 Walker B; other site 768492013942 D-loop; other site 768492013943 H-loop/switch region; other site 768492013944 TOBE domain; Region: TOBE_2; cl01440 768492013945 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492013946 dimer interface [polypeptide binding]; other site 768492013947 conserved gate region; other site 768492013948 putative PBP binding loops; other site 768492013949 ABC-ATPase subunit interface; other site 768492013950 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 768492013951 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492013952 putative PBP binding loops; other site 768492013953 ABC-ATPase subunit interface; other site 768492013954 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 768492013955 Sulfatase; Region: Sulfatase; cl10460 768492013956 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 768492013957 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492013958 transcriptional regulator protein; Region: phnR; TIGR03337 768492013959 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492013960 DNA-binding site [nucleotide binding]; DNA binding site 768492013961 UTRA domain; Region: UTRA; cl01230 768492013962 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 768492013963 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 768492013964 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 768492013965 substrate binding pocket [chemical binding]; other site 768492013966 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 768492013967 B12 binding site [chemical binding]; other site 768492013968 cobalt ligand [ion binding]; other site 768492013969 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 768492013970 transcriptional repressor IclR; Provisional; Region: PRK11569 768492013971 Helix-turn-helix domains; Region: HTH; cl00088 768492013972 Bacterial transcriptional regulator; Region: IclR; pfam01614 768492013973 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 768492013974 ATP-binding site [chemical binding]; other site 768492013975 Gluconate-6-phosphate binding site [chemical binding]; other site 768492013976 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 768492013977 GntP family permease; Region: GntP_permease; pfam02447 768492013978 Dehydratase family; Region: ILVD_EDD; cl00340 768492013979 6-phosphogluconate dehydratase; Region: edd; TIGR01196 768492013980 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 768492013981 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 768492013982 active site 768492013983 intersubunit interface [polypeptide binding]; other site 768492013984 catalytic residue [active] 768492013985 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 768492013986 Isocitrate dehydrogenase kinase/phosphatase (AceK); Region: AceK; cl01891 768492013987 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 768492013988 tetramer interface [polypeptide binding]; other site 768492013989 active site 768492013990 Mg2+/Mn2+ binding site [ion binding]; other site 768492013991 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 768492013992 malate synthase A; Region: malate_syn_A; TIGR01344 768492013993 active site 768492013994 homoserine O-succinyltransferase; Provisional; Region: PRK05368 768492013995 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 768492013996 proposed active site lysine [active] 768492013997 conserved cys residue [active] 768492013998 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 768492013999 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 768492014000 trimer interface [polypeptide binding]; other site 768492014001 putative metal binding site [ion binding]; other site 768492014002 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 768492014003 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 768492014004 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 768492014005 shikimate binding site; other site 768492014006 NAD(P) binding site [chemical binding]; other site 768492014007 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 768492014008 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 768492014009 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 768492014010 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 768492014011 Protein of unknown function (DUF494); Region: DUF494; cl01103 768492014012 hypothetical protein; Provisional; Region: PRK10736 768492014013 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 768492014014 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 768492014015 active site 768492014016 catalytic residues [active] 768492014017 metal binding site [ion binding]; metal-binding site 768492014018 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 768492014019 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 768492014020 putative active site [active] 768492014021 substrate binding site [chemical binding]; other site 768492014022 putative cosubstrate binding site; other site 768492014023 catalytic site [active] 768492014024 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 768492014025 substrate binding site [chemical binding]; other site 768492014026 16S rRNA methyltransferase B; Provisional; Region: PRK10901 768492014027 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 768492014028 putative RNA binding site [nucleotide binding]; other site 768492014029 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492014030 S-adenosylmethionine binding site [chemical binding]; other site 768492014031 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 768492014032 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492014033 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 768492014034 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492014035 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 768492014036 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 768492014037 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 768492014038 Domain of unknown function; Region: DUF331; cl01149 768492014039 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 768492014040 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 768492014041 DNA binding residues [nucleotide binding] 768492014042 dimer interface [polypeptide binding]; other site 768492014043 metal binding site [ion binding]; metal-binding site 768492014044 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 768492014045 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 768492014046 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 768492014047 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 768492014048 alphaNTD homodimer interface [polypeptide binding]; other site 768492014049 alphaNTD - beta interaction site [polypeptide binding]; other site 768492014050 alphaNTD - beta' interaction site [polypeptide binding]; other site 768492014051 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 768492014052 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 768492014053 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 768492014054 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768492014055 RNA binding surface [nucleotide binding]; other site 768492014056 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 768492014057 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 768492014058 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 768492014059 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 768492014060 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 768492014061 SecY translocase; Region: SecY; pfam00344 768492014062 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 768492014063 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 768492014064 23S rRNA binding site [nucleotide binding]; other site 768492014065 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 768492014066 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 768492014067 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 768492014068 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 768492014069 5S rRNA interface [nucleotide binding]; other site 768492014070 23S rRNA interface [nucleotide binding]; other site 768492014071 L5 interface [polypeptide binding]; other site 768492014072 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 768492014073 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 768492014074 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 768492014075 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 768492014076 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 768492014077 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 768492014078 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 768492014079 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 768492014080 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 768492014081 KOW motif; Region: KOW; cl00354 768492014082 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 768492014083 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 768492014084 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 768492014085 23S rRNA interface [nucleotide binding]; other site 768492014086 putative translocon interaction site; other site 768492014087 signal recognition particle (SRP54) interaction site; other site 768492014088 L23 interface [polypeptide binding]; other site 768492014089 trigger factor interaction site; other site 768492014090 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 768492014091 23S rRNA interface [nucleotide binding]; other site 768492014092 5S rRNA interface [nucleotide binding]; other site 768492014093 putative antibiotic binding site [chemical binding]; other site 768492014094 L25 interface [polypeptide binding]; other site 768492014095 L27 interface [polypeptide binding]; other site 768492014096 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 768492014097 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 768492014098 G-X-X-G motif; other site 768492014099 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 768492014100 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 768492014101 protein-rRNA interface [nucleotide binding]; other site 768492014102 putative translocon binding site; other site 768492014103 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 768492014104 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 768492014105 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 768492014106 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 768492014107 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 768492014108 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 768492014109 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 768492014110 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 768492014111 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 768492014112 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 768492014113 heme binding site [chemical binding]; other site 768492014114 ferroxidase pore; other site 768492014115 ferroxidase diiron center [ion binding]; other site 768492014116 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 768492014117 elongation factor Tu; Reviewed; Region: PRK00049 768492014118 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 768492014119 G1 box; other site 768492014120 GEF interaction site [polypeptide binding]; other site 768492014121 GTP/Mg2+ binding site [chemical binding]; other site 768492014122 Switch I region; other site 768492014123 G2 box; other site 768492014124 G3 box; other site 768492014125 Switch II region; other site 768492014126 G4 box; other site 768492014127 G5 box; other site 768492014128 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 768492014129 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 768492014130 Antibiotic Binding Site [chemical binding]; other site 768492014131 elongation factor G; Reviewed; Region: PRK00007 768492014132 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 768492014133 G1 box; other site 768492014134 putative GEF interaction site [polypeptide binding]; other site 768492014135 GTP/Mg2+ binding site [chemical binding]; other site 768492014136 Switch I region; other site 768492014137 G2 box; other site 768492014138 G3 box; other site 768492014139 Switch II region; other site 768492014140 G4 box; other site 768492014141 G5 box; other site 768492014142 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 768492014143 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 768492014144 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 768492014145 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 768492014146 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 768492014147 S17 interaction site [polypeptide binding]; other site 768492014148 S8 interaction site; other site 768492014149 16S rRNA interaction site [nucleotide binding]; other site 768492014150 streptomycin interaction site [chemical binding]; other site 768492014151 23S rRNA interaction site [nucleotide binding]; other site 768492014152 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 768492014153 DsrE/DsrF-like family; Region: DrsE; cl00672 768492014154 DsrE/DsrF-like family; Region: DrsE; cl00672 768492014155 DsrE/DsrF-like family; Region: DrsE; cl00672 768492014156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 768492014157 YheO-like PAS domain; Region: PAS_6; pfam08348 768492014158 Helix-turn-helix domains; Region: HTH; cl00088 768492014159 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 768492014160 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 768492014161 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 768492014162 SlyX; Region: SlyX; cl01090 768492014163 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 768492014164 Probable metal-binding protein (DUF2387); Region: DUF2387; cl01410 768492014165 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 768492014166 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 768492014167 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492014168 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 768492014169 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 768492014170 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492014171 Walker A/P-loop; other site 768492014172 ATP binding site [chemical binding]; other site 768492014173 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 768492014174 ABC transporter signature motif; other site 768492014175 Walker B; other site 768492014176 D-loop; other site 768492014177 ABC transporter; Region: ABC_tran_2; pfam12848 768492014178 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 768492014179 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 768492014180 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 768492014181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492014182 dimer interface [polypeptide binding]; other site 768492014183 conserved gate region; other site 768492014184 putative PBP binding loops; other site 768492014185 ABC-ATPase subunit interface; other site 768492014186 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 768492014187 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 768492014188 Walker A/P-loop; other site 768492014189 ATP binding site [chemical binding]; other site 768492014190 Q-loop/lid; other site 768492014191 ABC transporter signature motif; other site 768492014192 Walker B; other site 768492014193 D-loop; other site 768492014194 H-loop/switch region; other site 768492014195 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 768492014196 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492014197 substrate binding pocket [chemical binding]; other site 768492014198 membrane-bound complex binding site; other site 768492014199 hinge residues; other site 768492014200 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 768492014201 LysE type translocator; Region: LysE; cl00565 768492014202 putative hydrolase; Provisional; Region: PRK10985 768492014203 Uncharacterized protein family (UPF0270); Region: UPF0270; cl01180 768492014204 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492014205 OsmC-like protein; Region: OsmC; cl00767 768492014206 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 768492014207 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 768492014208 ligand binding site [chemical binding]; other site 768492014209 flexible hinge region; other site 768492014210 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 768492014211 putative switch regulator; other site 768492014212 non-specific DNA interactions [nucleotide binding]; other site 768492014213 DNA binding site [nucleotide binding] 768492014214 sequence specific DNA binding site [nucleotide binding]; other site 768492014215 putative cAMP binding site [chemical binding]; other site 768492014216 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 768492014217 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 768492014218 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 768492014219 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 768492014220 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768492014221 inhibitor-cofactor binding pocket; inhibition site 768492014222 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492014223 catalytic residue [active] 768492014224 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 768492014225 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 768492014226 glutamine binding [chemical binding]; other site 768492014227 catalytic triad [active] 768492014228 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 768492014229 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492014230 Walker A motif; other site 768492014231 ATP binding site [chemical binding]; other site 768492014232 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 768492014233 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 768492014234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492014235 active site 768492014236 phosphorylation site [posttranslational modification] 768492014237 intermolecular recognition site; other site 768492014238 dimerization interface [polypeptide binding]; other site 768492014239 LytTr DNA-binding domain; Region: LytTR; cl04498 768492014240 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 768492014241 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 768492014242 GAF domain; Region: GAF; cl15785 768492014243 Histidine kinase; Region: His_kinase; pfam06580 768492014244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 768492014245 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 768492014246 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 768492014247 substrate binding site [chemical binding]; other site 768492014248 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 768492014249 active site 768492014250 methionine cluster; other site 768492014251 phosphorylation site [posttranslational modification] 768492014252 metal binding site [ion binding]; metal-binding site 768492014253 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 768492014254 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 768492014255 NAD binding site [chemical binding]; other site 768492014256 sugar binding site [chemical binding]; other site 768492014257 divalent metal binding site [ion binding]; other site 768492014258 tetramer (dimer of dimers) interface [polypeptide binding]; other site 768492014259 dimer interface [polypeptide binding]; other site 768492014260 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768492014261 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492014262 DNA binding site [nucleotide binding] 768492014263 domain linker motif; other site 768492014264 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 768492014265 dimerization interface (closed form) [polypeptide binding]; other site 768492014266 ligand binding site [chemical binding]; other site 768492014267 putative transporter; Provisional; Region: PRK03699 768492014268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492014269 putative substrate translocation pore; other site 768492014270 cytosine deaminase; Provisional; Region: PRK09230 768492014271 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 768492014272 active site 768492014273 nitrite reductase subunit NirD; Provisional; Region: PRK14989 768492014274 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768492014275 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 768492014276 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 768492014277 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 768492014278 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 768492014279 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 768492014280 siroheme synthase; Provisional; Region: cysG; PRK10637 768492014281 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492014282 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 768492014283 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 768492014284 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 768492014285 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 768492014286 active site 768492014287 HIGH motif; other site 768492014288 dimer interface [polypeptide binding]; other site 768492014289 KMSKS motif; other site 768492014290 phosphoglycolate phosphatase; Provisional; Region: PRK13222 768492014291 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 768492014292 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492014293 motif II; other site 768492014294 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 768492014295 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 768492014296 substrate binding site [chemical binding]; other site 768492014297 hexamer interface [polypeptide binding]; other site 768492014298 metal binding site [ion binding]; metal-binding site 768492014299 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 768492014300 hypothetical protein; Reviewed; Region: PRK11901 768492014301 Sporulation related domain; Region: SPOR; cl10051 768492014302 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 768492014303 active site 768492014304 dimer interface [polypeptide binding]; other site 768492014305 metal binding site [ion binding]; metal-binding site 768492014306 shikimate kinase; Reviewed; Region: aroK; PRK00131 768492014307 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 768492014308 ADP binding site [chemical binding]; other site 768492014309 magnesium binding site [ion binding]; other site 768492014310 putative shikimate binding site; other site 768492014311 putative outer membrane porin HofQ; Provisional; Region: hofQ; PRK13568 768492014312 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 768492014313 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 768492014314 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 768492014315 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 768492014316 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 768492014317 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 768492014318 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 768492014319 Transglycosylase; Region: Transgly; cl07896 768492014320 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 768492014321 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 768492014322 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 768492014323 dimer interface [polypeptide binding]; other site 768492014324 ADP-ribose binding site [chemical binding]; other site 768492014325 active site 768492014326 nudix motif; other site 768492014327 metal binding site [ion binding]; metal-binding site 768492014328 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 768492014329 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 768492014330 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492014331 motif II; other site 768492014332 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768492014333 RNA binding surface [nucleotide binding]; other site 768492014334 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 768492014335 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 768492014336 dimerization interface [polypeptide binding]; other site 768492014337 domain crossover interface; other site 768492014338 redox-dependent activation switch; other site 768492014339 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 768492014340 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 768492014341 active site 768492014342 substrate-binding site [chemical binding]; other site 768492014343 metal-binding site [ion binding] 768492014344 ATP binding site [chemical binding]; other site 768492014345 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 768492014346 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 768492014347 oligomeric interface; other site 768492014348 putative active site [active] 768492014349 homodimer interface [polypeptide binding]; other site 768492014350 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 768492014351 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 768492014352 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492014353 dimer interface [polypeptide binding]; other site 768492014354 phosphorylation site [posttranslational modification] 768492014355 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492014356 ATP binding site [chemical binding]; other site 768492014357 G-X-G motif; other site 768492014358 osmolarity response regulator; Provisional; Region: ompR; PRK09468 768492014359 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492014360 active site 768492014361 phosphorylation site [posttranslational modification] 768492014362 intermolecular recognition site; other site 768492014363 dimerization interface [polypeptide binding]; other site 768492014364 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768492014365 DNA binding site [nucleotide binding] 768492014366 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 768492014367 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 768492014368 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 768492014369 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 768492014370 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 768492014371 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 768492014372 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 768492014373 RNA binding site [nucleotide binding]; other site 768492014374 FeoA domain; Region: FeoA; cl00838 768492014375 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 768492014376 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 768492014377 G1 box; other site 768492014378 GTP/Mg2+ binding site [chemical binding]; other site 768492014379 Switch I region; other site 768492014380 G2 box; other site 768492014381 G3 box; other site 768492014382 Switch II region; other site 768492014383 G4 box; other site 768492014384 G5 box; other site 768492014385 Nucleoside recognition; Region: Gate; cl00486 768492014386 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 768492014387 Nucleoside recognition; Region: Gate; cl00486 768492014388 Helix-turn-helix domains; Region: HTH; cl00088 768492014389 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 768492014390 carboxylesterase BioH; Provisional; Region: PRK10349 768492014391 DNA utilization protein GntX; Provisional; Region: PRK11595 768492014392 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768492014393 active site 768492014394 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 768492014395 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 768492014396 NifU-like domain; Region: NifU; cl00484 768492014397 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 768492014398 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 768492014399 maltodextrin phosphorylase; Provisional; Region: PRK14985 768492014400 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 768492014401 active site pocket [active] 768492014402 transcriptional regulator MalT; Provisional; Region: PRK04841 768492014403 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492014404 DNA binding residues [nucleotide binding] 768492014405 dimerization interface [polypeptide binding]; other site 768492014406 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 768492014407 active site residue [active] 768492014408 D-galactonate transporter; Region: 2A0114; TIGR00893 768492014409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492014410 putative substrate translocation pore; other site 768492014411 Domain of unknown function (DUF386); Region: DUF386; cl01047 768492014412 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 768492014413 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 768492014414 inhibitor site; inhibition site 768492014415 active site 768492014416 dimer interface [polypeptide binding]; other site 768492014417 catalytic residue [active] 768492014418 Helix-turn-helix domains; Region: HTH; cl00088 768492014419 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 768492014420 substrate binding site [chemical binding]; other site 768492014421 dimer interface [polypeptide binding]; other site 768492014422 ATP binding site [chemical binding]; other site 768492014423 intramembrane serine protease GlpG; Provisional; Region: PRK10907 768492014424 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 768492014425 Rhomboid family; Region: Rhomboid; cl11446 768492014426 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 768492014427 Helix-turn-helix domains; Region: HTH; cl00088 768492014428 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 768492014429 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 768492014430 glycogen phosphorylase; Provisional; Region: PRK14986 768492014431 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 768492014432 homodimer interface [polypeptide binding]; other site 768492014433 active site pocket [active] 768492014434 glycogen synthase; Provisional; Region: glgA; PRK00654 768492014435 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 768492014436 ADP-binding pocket [chemical binding]; other site 768492014437 homodimer interface [polypeptide binding]; other site 768492014438 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 768492014439 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 768492014440 ligand binding site; other site 768492014441 oligomer interface; other site 768492014442 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 768492014443 sulfate 1 binding site; other site 768492014444 glycogen debranching enzyme; Provisional; Region: PRK03705 768492014445 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 768492014446 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 768492014447 active site 768492014448 catalytic site [active] 768492014449 glycogen branching enzyme; Provisional; Region: PRK05402 768492014450 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 768492014451 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 768492014452 active site 768492014453 catalytic site [active] 768492014454 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 768492014455 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 768492014456 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492014457 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 768492014458 MarC family integral membrane protein; Region: MarC; cl00919 768492014459 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 768492014460 ATP-binding site [chemical binding]; other site 768492014461 Gluconate-6-phosphate binding site [chemical binding]; other site 768492014462 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 768492014463 gluconate transporter; Region: gntP; TIGR00791 768492014464 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 768492014465 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492014466 DNA binding site [nucleotide binding] 768492014467 domain linker motif; other site 768492014468 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 768492014469 putative ligand binding site [chemical binding]; other site 768492014470 putative dimerization interface [polypeptide binding]; other site 768492014471 Cupin domain; Region: Cupin_2; cl09118 768492014472 putative acetyltransferase YhhY; Provisional; Region: PRK10140 768492014473 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492014474 Coenzyme A binding pocket [chemical binding]; other site 768492014475 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 768492014476 putative active site pocket [active] 768492014477 cleavage site 768492014478 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 768492014479 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 768492014480 Metal-binding active site; metal-binding site 768492014481 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 768492014482 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768492014483 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492014484 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 768492014485 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 768492014486 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768492014487 PYR/PP interface [polypeptide binding]; other site 768492014488 dimer interface [polypeptide binding]; other site 768492014489 TPP binding site [chemical binding]; other site 768492014490 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 768492014491 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 768492014492 TPP-binding site; other site 768492014493 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768492014494 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 768492014495 substrate binding site [chemical binding]; other site 768492014496 ATP binding site [chemical binding]; other site 768492014497 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 768492014498 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 768492014499 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768492014500 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768492014501 putative active site [active] 768492014502 KduI/IolB family; Region: KduI; cl01508 768492014503 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 768492014504 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 768492014505 tetrameric interface [polypeptide binding]; other site 768492014506 NAD binding site [chemical binding]; other site 768492014507 catalytic residues [active] 768492014508 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 768492014509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492014510 putative substrate translocation pore; other site 768492014511 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492014512 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 768492014513 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 768492014514 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 768492014515 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 768492014516 Walker A/P-loop; other site 768492014517 ATP binding site [chemical binding]; other site 768492014518 Q-loop/lid; other site 768492014519 ABC transporter signature motif; other site 768492014520 Walker B; other site 768492014521 D-loop; other site 768492014522 H-loop/switch region; other site 768492014523 FaeA-like protein; Region: FaeA; pfam04703 768492014524 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 768492014525 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 768492014526 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 768492014527 Fimbrial protein; Region: Fimbrial; cl01416 768492014528 Fimbrial protein; Region: Fimbrial; cl01416 768492014529 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 768492014530 PapC N-terminal domain; Region: PapC_N; pfam13954 768492014531 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 768492014532 PapC C-terminal domain; Region: PapC_C; pfam13953 768492014533 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 768492014534 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 768492014535 Fimbrial protein; Region: Fimbrial; cl01416 768492014536 Fimbrial protein; Region: Fimbrial; cl01416 768492014537 Fimbrial protein; Region: Fimbrial; cl01416 768492014538 O-Antigen ligase; Region: Wzy_C; cl04850 768492014539 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 768492014540 fimbriae regulatory protein FimW; Provisional; Region: PRK15201 768492014541 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492014542 DNA binding residues [nucleotide binding] 768492014543 dimerization interface [polypeptide binding]; other site 768492014544 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 768492014545 Amidinotransferase; Region: Amidinotransf; cl12043 768492014546 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768492014547 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768492014548 putative DNA binding site [nucleotide binding]; other site 768492014549 putative Zn2+ binding site [ion binding]; other site 768492014550 Helix-turn-helix domains; Region: HTH; cl00088 768492014551 Arginase family; Region: Arginase; cl00306 768492014552 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502 768492014553 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 768492014554 Protein of unknown function (DUF330); Region: DUF330; cl01135 768492014555 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 768492014556 mce related protein; Region: MCE; pfam02470 768492014557 mce related protein; Region: MCE; pfam02470 768492014558 mce related protein; Region: MCE; pfam02470 768492014559 Paraquat-inducible protein A; Region: PqiA; pfam04403 768492014560 Paraquat-inducible protein A; Region: PqiA; pfam04403 768492014561 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 768492014562 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492014563 Helix-turn-helix domains; Region: HTH; cl00088 768492014564 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 768492014565 HI0933-like protein; Region: HI0933_like; pfam03486 768492014566 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492014567 Phosphate transporter family; Region: PHO4; cl00396 768492014568 Phosphate transporter family; Region: PHO4; cl00396 768492014569 Universal stress protein B (UspB); Region: UspB; cl11669 768492014570 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 768492014571 Ligand Binding Site [chemical binding]; other site 768492014572 glutamate dehydrogenase; Provisional; Region: PRK09414 768492014573 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 768492014574 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 768492014575 NAD(P) binding site [chemical binding]; other site 768492014576 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 768492014577 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 768492014578 ligand binding site [chemical binding]; other site 768492014579 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 768492014580 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 768492014581 Walker A/P-loop; other site 768492014582 ATP binding site [chemical binding]; other site 768492014583 Q-loop/lid; other site 768492014584 ABC transporter signature motif; other site 768492014585 Walker B; other site 768492014586 D-loop; other site 768492014587 H-loop/switch region; other site 768492014588 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 768492014589 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768492014590 TM-ABC transporter signature motif; other site 768492014591 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768492014592 TM-ABC transporter signature motif; other site 768492014593 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 768492014594 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 768492014595 N- and C-terminal domain interface [polypeptide binding]; other site 768492014596 putative active site [active] 768492014597 putative MgATP binding site [chemical binding]; other site 768492014598 catalytic site [active] 768492014599 metal binding site [ion binding]; metal-binding site 768492014600 carbohydrate binding site [chemical binding]; other site 768492014601 putative homodimer interface [polypeptide binding]; other site 768492014602 Predicted sugar phosphate isomerase involved in capsule formation [Cell envelope biogenesis, outer membrane]; Region: GutQ; COG0794 768492014603 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 768492014604 putative active site [active] 768492014605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 768492014606 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 768492014607 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 768492014608 active site 768492014609 Zn binding site [ion binding]; other site 768492014610 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 768492014611 nucleotide binding site/active site [active] 768492014612 HIT family signature motif; other site 768492014613 catalytic residue [active] 768492014614 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 768492014615 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 768492014616 glutathione reductase; Validated; Region: PRK06116 768492014617 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768492014618 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768492014619 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 768492014620 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 768492014621 Surface antigen; Region: Bac_surface_Ag; cl03097 768492014622 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 768492014623 haemagglutination activity domain; Region: Haemagg_act; cl05436 768492014624 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768492014625 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492014626 DNA binding residues [nucleotide binding] 768492014627 dimerization interface [polypeptide binding]; other site 768492014628 O-Antigen ligase; Region: Wzy_C; cl04850 768492014629 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 768492014630 Fimbrial protein; Region: Fimbrial; cl01416 768492014631 Fimbrial protein; Region: Fimbrial; cl01416 768492014632 Fimbrial protein; Region: Fimbrial; cl01416 768492014633 Fimbrial protein; Region: Fimbrial; cl01416 768492014634 fimbrial assembly chaperone StbE; Provisional; Region: PRK15246 768492014635 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 768492014636 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 768492014637 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 768492014638 PapC N-terminal domain; Region: PapC_N; pfam13954 768492014639 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 768492014640 PapC C-terminal domain; Region: PapC_C; pfam13953 768492014641 Fimbrial protein; Region: Fimbrial; cl01416 768492014642 Fimbrial protein; Region: Fimbrial; cl01416 768492014643 Helix-turn-helix domains; Region: HTH; cl00088 768492014644 DNA binding site [nucleotide binding] 768492014645 Helix-turn-helix domains; Region: HTH; cl00088 768492014646 haemagglutination activity domain; Region: Haemagg_act; cl05436 768492014647 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 768492014648 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 768492014649 Surface antigen; Region: Bac_surface_Ag; cl03097 768492014650 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 768492014651 DinB superfamily; Region: DinB_2; pfam12867 768492014652 Cupin domain; Region: Cupin_2; cl09118 768492014653 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492014654 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768492014655 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492014656 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 768492014657 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492014658 dimer interface [polypeptide binding]; other site 768492014659 phosphorylation site [posttranslational modification] 768492014660 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492014661 ATP binding site [chemical binding]; other site 768492014662 Mg2+ binding site [ion binding]; other site 768492014663 G-X-G motif; other site 768492014664 Response regulator receiver domain; Region: Response_reg; pfam00072 768492014665 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492014666 active site 768492014667 phosphorylation site [posttranslational modification] 768492014668 intermolecular recognition site; other site 768492014669 dimerization interface [polypeptide binding]; other site 768492014670 BetR domain; Region: BetR; pfam08667 768492014671 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 768492014672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492014673 active site 768492014674 phosphorylation site [posttranslational modification] 768492014675 intermolecular recognition site; other site 768492014676 dimerization interface [polypeptide binding]; other site 768492014677 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 768492014678 catalytic triad [active] 768492014679 putative active site [active] 768492014680 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 768492014681 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 768492014682 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 768492014683 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 768492014684 catalytic triad [active] 768492014685 putative active site [active] 768492014686 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 768492014687 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 768492014688 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 768492014689 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492014690 Helix-turn-helix domains; Region: HTH; cl00088 768492014691 Uncharacterized protein family (UPF0261); Region: UPF0261; cl02262 768492014692 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424 768492014693 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 768492014694 dimer interface [polypeptide binding]; other site 768492014695 RNase II stability modulator; Provisional; Region: PRK10060 768492014696 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768492014697 putative active site [active] 768492014698 heme pocket [chemical binding]; other site 768492014699 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768492014700 metal binding site [ion binding]; metal-binding site 768492014701 active site 768492014702 I-site; other site 768492014703 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768492014704 enoyl-CoA hydratase; Validated; Region: PRK08788 768492014705 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768492014706 substrate binding site [chemical binding]; other site 768492014707 oxyanion hole (OAH) forming residues; other site 768492014708 trimer interface [polypeptide binding]; other site 768492014709 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 768492014710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492014711 metabolite-proton symporter; Region: 2A0106; TIGR00883 768492014712 putative substrate translocation pore; other site 768492014713 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 768492014714 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 768492014715 AsmA-like C-terminal region; Region: AsmA_2; cl15864 768492014716 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768492014717 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 768492014718 active site 1 [active] 768492014719 dimer interface [polypeptide binding]; other site 768492014720 hexamer interface [polypeptide binding]; other site 768492014721 active site 2 [active] 768492014722 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768492014723 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 768492014724 substrate binding site [chemical binding]; other site 768492014725 ATP binding site [chemical binding]; other site 768492014726 ketol-acid reductoisomerase; Validated; Region: PRK05225 768492014727 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492014728 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 768492014729 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 768492014730 Helix-turn-helix domains; Region: HTH; cl00088 768492014731 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 768492014732 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 768492014733 putative dimerization interface [polypeptide binding]; other site 768492014734 Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374 768492014735 threonine dehydratase; Reviewed; Region: PRK09224 768492014736 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 768492014737 tetramer interface [polypeptide binding]; other site 768492014738 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492014739 catalytic residue [active] 768492014740 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 768492014741 putative Ile/Val binding site [chemical binding]; other site 768492014742 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 768492014743 putative Ile/Val binding site [chemical binding]; other site 768492014744 Dehydratase family; Region: ILVD_EDD; cl00340 768492014745 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 768492014746 homodimer interface [polypeptide binding]; other site 768492014747 substrate-cofactor binding pocket; other site 768492014748 catalytic residue [active] 768492014749 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 768492014750 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 768492014751 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768492014752 PYR/PP interface [polypeptide binding]; other site 768492014753 dimer interface [polypeptide binding]; other site 768492014754 TPP binding site [chemical binding]; other site 768492014755 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 768492014756 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 768492014757 TPP-binding site [chemical binding]; other site 768492014758 dimer interface [polypeptide binding]; other site 768492014759 ilvG operon leader peptide; Provisional; Region: PRK10424 768492014760 putative sialic acid transporter; Region: 2A0112; TIGR00891 768492014761 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492014762 putative substrate translocation pore; other site 768492014763 putative ATP-dependent protease; Provisional; Region: PRK09862 768492014764 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 768492014765 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492014766 Walker A motif; other site 768492014767 ATP binding site [chemical binding]; other site 768492014768 Walker B motif; other site 768492014769 arginine finger; other site 768492014770 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 768492014771 Protein of unknown function, DUF; Region: DUF413; cl10479 768492014772 transcriptional regulator HdfR; Provisional; Region: PRK03601 768492014773 Helix-turn-helix domains; Region: HTH; cl00088 768492014774 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768492014775 dimerization interface [polypeptide binding]; other site 768492014776 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768492014777 TM-ABC transporter signature motif; other site 768492014778 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768492014779 TM-ABC transporter signature motif; other site 768492014780 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 768492014781 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492014782 Walker A/P-loop; other site 768492014783 ATP binding site [chemical binding]; other site 768492014784 Q-loop/lid; other site 768492014785 ABC transporter signature motif; other site 768492014786 Walker B; other site 768492014787 D-loop; other site 768492014788 H-loop/switch region; other site 768492014789 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 768492014790 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 768492014791 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 768492014792 putative ligand binding site [chemical binding]; other site 768492014793 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 768492014794 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 768492014795 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768492014796 N-terminal plug; other site 768492014797 ligand-binding site [chemical binding]; other site 768492014798 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 768492014799 tRNA (uracil-5-)-methyltransferase; Region: trmA_only; TIGR02143 768492014800 Protein of unknown function (DUF1422); Region: DUF1422; cl11649 768492014801 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 768492014802 Helix-turn-helix domains; Region: HTH; cl00088 768492014803 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 768492014804 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768492014805 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768492014806 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 768492014807 Helix-turn-helix domains; Region: HTH; cl00088 768492014808 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 768492014809 dimerization interface [polypeptide binding]; other site 768492014810 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 768492014811 catalytic triad [active] 768492014812 dimer interface [polypeptide binding]; other site 768492014813 Glutaredoxin (GRX) family, PRX5 hybrid subfamily; composed of hybrid proteins containing peroxiredoxin (PRX) and GRX domains, which is found in some pathogenic bacteria and cyanobacteria. PRXs are thiol-specific antioxidant (TSA) proteins that confer a...; Region: GRX_hybridPRX5; cd03029 768492014814 GSH binding site [chemical binding]; other site 768492014815 catalytic residues [active] 768492014816 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 768492014817 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768492014818 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768492014819 argininosuccinate lyase; Provisional; Region: PRK04833 768492014820 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 768492014821 active sites [active] 768492014822 tetramer interface [polypeptide binding]; other site 768492014823 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 768492014824 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 768492014825 ANP binding site [chemical binding]; other site 768492014826 Substrate Binding Site II [chemical binding]; other site 768492014827 Substrate Binding Site I [chemical binding]; other site 768492014828 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 768492014829 nucleotide binding site [chemical binding]; other site 768492014830 N-acetyl-L-glutamate binding site [chemical binding]; other site 768492014831 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 768492014832 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492014833 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 768492014834 acetylornithine deacetylase; Provisional; Region: PRK05111 768492014835 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 768492014836 metal binding site [ion binding]; metal-binding site 768492014837 putative dimer interface [polypeptide binding]; other site 768492014838 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 768492014839 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 768492014840 Cupin domain; Region: Cupin_2; cl09118 768492014841 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492014842 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768492014843 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492014844 LysE type translocator; Region: LysE; cl00565 768492014845 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 768492014846 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 768492014847 FAD binding site [chemical binding]; other site 768492014848 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 768492014849 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 768492014850 putative catalytic residues [active] 768492014851 putative nucleotide binding site [chemical binding]; other site 768492014852 putative aspartate binding site [chemical binding]; other site 768492014853 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492014854 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 768492014855 cystathionine gamma-synthase; Provisional; Region: PRK08045 768492014856 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 768492014857 homodimer interface [polypeptide binding]; other site 768492014858 substrate-cofactor binding pocket; other site 768492014859 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492014860 catalytic residue [active] 768492014861 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox' sequence. MetJ...; Region: Met_repressor_MetJ; cd00490 768492014862 dimerization interface [polypeptide binding]; other site 768492014863 DNA binding site [nucleotide binding] 768492014864 corepressor binding sites; other site 768492014865 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 768492014866 primosome assembly protein PriA; Validated; Region: PRK05580 768492014867 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768492014868 ATP binding site [chemical binding]; other site 768492014869 putative Mg++ binding site [ion binding]; other site 768492014870 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492014871 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492014872 DNA binding site [nucleotide binding] 768492014873 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 768492014874 domain linker motif; other site 768492014875 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 768492014876 dimerization interface [polypeptide binding]; other site 768492014877 ligand binding site [chemical binding]; other site 768492014878 Sporulation related domain; Region: SPOR; cl10051 768492014879 Sporulation related domain; Region: SPOR; cl10051 768492014880 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 768492014881 active site 768492014882 HslU subunit interaction site [polypeptide binding]; other site 768492014883 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 768492014884 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492014885 Walker A motif; other site 768492014886 ATP binding site [chemical binding]; other site 768492014887 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 768492014888 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 768492014889 UbiA prenyltransferase family; Region: UbiA; cl00337 768492014890 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 768492014891 Protein of unknown function (DUF904); Region: DUF904; cl11531 768492014892 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 768492014893 amphipathic channel; other site 768492014894 Asn-Pro-Ala signature motifs; other site 768492014895 glycerol kinase; Provisional; Region: glpK; PRK00047 768492014896 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 768492014897 N- and C-terminal domain interface [polypeptide binding]; other site 768492014898 active site 768492014899 MgATP binding site [chemical binding]; other site 768492014900 catalytic site [active] 768492014901 metal binding site [ion binding]; metal-binding site 768492014902 glycerol binding site [chemical binding]; other site 768492014903 homotetramer interface [polypeptide binding]; other site 768492014904 homodimer interface [polypeptide binding]; other site 768492014905 FBP binding site [chemical binding]; other site 768492014906 protein IIAGlc interface [polypeptide binding]; other site 768492014907 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 768492014908 putative active site [active] 768492014909 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 768492014910 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492014911 putative substrate translocation pore; other site 768492014912 Predicted transcriptional regulator [Transcription]; Region: COG2345 768492014913 Helix-turn-helix domains; Region: HTH; cl00088 768492014914 ferredoxin-NADP reductase; Provisional; Region: PRK10926 768492014915 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 768492014916 FAD binding pocket [chemical binding]; other site 768492014917 FAD binding motif [chemical binding]; other site 768492014918 phosphate binding motif [ion binding]; other site 768492014919 beta-alpha-beta structure motif; other site 768492014920 NAD binding pocket [chemical binding]; other site 768492014921 Protein of unknown function (DUF805); Region: DUF805; cl01224 768492014922 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 768492014923 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 768492014924 substrate binding site [chemical binding]; other site 768492014925 dimer interface [polypeptide binding]; other site 768492014926 catalytic triad [active] 768492014927 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492014928 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 768492014929 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 768492014930 active site 768492014931 ADP/pyrophosphate binding site [chemical binding]; other site 768492014932 dimerization interface [polypeptide binding]; other site 768492014933 allosteric effector site; other site 768492014934 fructose-1,6-bisphosphate binding site; other site 768492014935 Cation efflux family; Region: Cation_efflux; cl00316 768492014936 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 768492014937 dimer interface [polypeptide binding]; other site 768492014938 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 768492014939 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492014940 active site 768492014941 phosphorylation site [posttranslational modification] 768492014942 intermolecular recognition site; other site 768492014943 dimerization interface [polypeptide binding]; other site 768492014944 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768492014945 DNA binding site [nucleotide binding] 768492014946 two-component sensor protein; Provisional; Region: cpxA; PRK09470 768492014947 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 768492014948 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492014949 dimer interface [polypeptide binding]; other site 768492014950 phosphorylation site [posttranslational modification] 768492014951 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492014952 ATP binding site [chemical binding]; other site 768492014953 Mg2+ binding site [ion binding]; other site 768492014954 G-X-G motif; other site 768492014955 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 768492014956 CHAD domain; Region: CHAD; cl10506 768492014957 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 768492014958 serine acetyltransferase; Provisional; Region: cysE; PRK11132 768492014959 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 768492014960 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 768492014961 trimer interface [polypeptide binding]; other site 768492014962 active site 768492014963 substrate binding site [chemical binding]; other site 768492014964 CoA binding site [chemical binding]; other site 768492014965 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 768492014966 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492014967 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 768492014968 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 768492014969 SecA binding site; other site 768492014970 Preprotein binding site; other site 768492014971 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 768492014972 GSH binding site [chemical binding]; other site 768492014973 catalytic residues [active] 768492014974 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 768492014975 active site residue [active] 768492014976 Sulfatase; Region: Sulfatase; cl10460 768492014977 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 768492014978 AmiB activator; Provisional; Region: PRK11637 768492014979 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 768492014980 NodB motif; other site 768492014981 putative active site [active] 768492014982 putative catalytic site [active] 768492014983 Zn binding site [ion binding]; other site 768492014984 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 768492014985 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 768492014986 NAD(P) binding site [chemical binding]; other site 768492014987 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 768492014988 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 768492014989 substrate-cofactor binding pocket; other site 768492014990 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492014991 catalytic residue [active] 768492014992 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 768492014993 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 768492014994 NADP binding site [chemical binding]; other site 768492014995 homopentamer interface [polypeptide binding]; other site 768492014996 substrate binding site [chemical binding]; other site 768492014997 active site 768492014998 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 768492014999 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 768492015000 putative active site [active] 768492015001 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 768492015002 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 768492015003 putative active site [active] 768492015004 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768492015005 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 768492015006 putative glycosyl transferase; Provisional; Region: PRK10073 768492015007 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 768492015008 active site 768492015009 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 768492015010 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 768492015011 putative active site [active] 768492015012 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 768492015013 putative active site [active] 768492015014 putative catalytic site [active] 768492015015 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 768492015016 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 768492015017 putative active site [active] 768492015018 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 768492015019 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768492015020 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768492015021 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 768492015022 putative ADP-binding pocket [chemical binding]; other site 768492015023 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 768492015024 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 768492015025 putative active site [active] 768492015026 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 768492015027 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 768492015028 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 768492015029 putative metal binding site; other site 768492015030 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 768492015031 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 768492015032 active site 768492015033 (T/H)XGH motif; other site 768492015034 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 768492015035 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 768492015036 DNA binding site [nucleotide binding] 768492015037 catalytic residue [active] 768492015038 H2TH interface [polypeptide binding]; other site 768492015039 putative catalytic residues [active] 768492015040 turnover-facilitating residue; other site 768492015041 intercalation triad [nucleotide binding]; other site 768492015042 8OG recognition residue [nucleotide binding]; other site 768492015043 putative reading head residues; other site 768492015044 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 768492015045 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 768492015046 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 768492015047 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 768492015048 hypothetical protein; Reviewed; Region: PRK00024 768492015049 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 768492015050 MPN+ (JAMM) motif; other site 768492015051 Zinc-binding site [ion binding]; other site 768492015052 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 768492015053 Flavoprotein; Region: Flavoprotein; cl08021 768492015054 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 768492015055 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 768492015056 trimer interface [polypeptide binding]; other site 768492015057 active site 768492015058 division inhibitor protein; Provisional; Region: slmA; PRK09480 768492015059 Helix-turn-helix domains; Region: HTH; cl00088 768492015060 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768492015061 active site 768492015062 ribonuclease PH; Reviewed; Region: rph; PRK00173 768492015063 Ribonuclease PH; Region: RNase_PH_bact; cd11362 768492015064 hexamer interface [polypeptide binding]; other site 768492015065 active site 768492015066 hypothetical protein; Provisional; Region: PRK11820 768492015067 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 768492015068 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 768492015069 nucleoside transporter; Region: nupC; TIGR00804 768492015070 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 768492015071 Nucleoside recognition; Region: Gate; cl00486 768492015072 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 768492015073 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 768492015074 Predicted membrane protein [Function unknown]; Region: COG2860 768492015075 UPF0126 domain; Region: UPF0126; pfam03458 768492015076 UPF0126 domain; Region: UPF0126; pfam03458 768492015077 transcriptional regulator; Provisional; Region: PRK10632 768492015078 Helix-turn-helix domains; Region: HTH; cl00088 768492015079 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 768492015080 putative effector binding pocket; other site 768492015081 putative dimerization interface [polypeptide binding]; other site 768492015082 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 768492015083 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492015084 putative substrate translocation pore; other site 768492015085 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 768492015086 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 768492015087 catalytic site [active] 768492015088 G-X2-G-X-G-K; other site 768492015089 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 768492015090 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 768492015091 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 768492015092 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 768492015093 synthetase active site [active] 768492015094 NTP binding site [chemical binding]; other site 768492015095 metal binding site [ion binding]; metal-binding site 768492015096 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 768492015097 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 768492015098 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 768492015099 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 768492015100 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 768492015101 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 768492015102 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 768492015103 generic binding surface II; other site 768492015104 ssDNA binding site; other site 768492015105 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768492015106 ATP binding site [chemical binding]; other site 768492015107 putative Mg++ binding site [ion binding]; other site 768492015108 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768492015109 nucleotide binding region [chemical binding]; other site 768492015110 ATP-binding site [chemical binding]; other site 768492015111 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 768492015112 uracil-xanthine permease; Region: ncs2; TIGR00801 768492015113 AsmA family; Region: AsmA; pfam05170 768492015114 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492015115 Coenzyme A binding pocket [chemical binding]; other site 768492015116 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 768492015117 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 768492015118 putative active site [active] 768492015119 dimerization interface [polypeptide binding]; other site 768492015120 putative tRNAtyr binding site [nucleotide binding]; other site 768492015121 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 768492015122 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 768492015123 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 768492015124 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492015125 motif II; other site 768492015126 GTP-binding protein; Provisional; Region: PRK10218 768492015127 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 768492015128 G1 box; other site 768492015129 putative GEF interaction site [polypeptide binding]; other site 768492015130 GTP/Mg2+ binding site [chemical binding]; other site 768492015131 Switch I region; other site 768492015132 G2 box; other site 768492015133 G3 box; other site 768492015134 Switch II region; other site 768492015135 G4 box; other site 768492015136 G5 box; other site 768492015137 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 768492015138 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 768492015139 glutamine synthetase; Provisional; Region: glnA; PRK09469 768492015140 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 768492015141 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 768492015142 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 768492015143 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 768492015144 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492015145 ATP binding site [chemical binding]; other site 768492015146 Mg2+ binding site [ion binding]; other site 768492015147 G-X-G motif; other site 768492015148 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 768492015149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492015150 active site 768492015151 phosphorylation site [posttranslational modification] 768492015152 intermolecular recognition site; other site 768492015153 dimerization interface [polypeptide binding]; other site 768492015154 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492015155 Walker A motif; other site 768492015156 ATP binding site [chemical binding]; other site 768492015157 Walker B motif; other site 768492015158 arginine finger; other site 768492015159 Helix-turn-helix domains; Region: HTH; cl00088 768492015160 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 768492015161 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768492015162 FeS/SAM binding site; other site 768492015163 HemN C-terminal domain; Region: HemN_C; pfam06969 768492015164 Der GTPase activator (YihI); Region: YihI; cl01172 768492015165 Predicted GTPase [General function prediction only]; Region: COG0218 768492015166 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 768492015167 G1 box; other site 768492015168 GTP/Mg2+ binding site [chemical binding]; other site 768492015169 Switch I region; other site 768492015170 G2 box; other site 768492015171 G3 box; other site 768492015172 Switch II region; other site 768492015173 G4 box; other site 768492015174 G5 box; other site 768492015175 DNA polymerase I; Provisional; Region: PRK05755 768492015176 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 768492015177 active site 768492015178 metal binding site 1 [ion binding]; metal-binding site 768492015179 putative 5' ssDNA interaction site; other site 768492015180 metal binding site 3; metal-binding site 768492015181 metal binding site 2 [ion binding]; metal-binding site 768492015182 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 768492015183 putative DNA binding site [nucleotide binding]; other site 768492015184 putative metal binding site [ion binding]; other site 768492015185 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 768492015186 active site 768492015187 catalytic site [active] 768492015188 substrate binding site [chemical binding]; other site 768492015189 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 768492015190 active site 768492015191 DNA binding site [nucleotide binding] 768492015192 catalytic site [active] 768492015193 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 768492015194 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 768492015195 putative acyl-acceptor binding pocket; other site 768492015196 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 768492015197 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 768492015198 catalytic residues [active] 768492015199 hinge region; other site 768492015200 alpha helical domain; other site 768492015201 Phosphotransferase enzyme family; Region: APH; pfam01636 768492015202 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 768492015203 active site 768492015204 ATP binding site [chemical binding]; other site 768492015205 Protein of unknown function (DUF1040); Region: DUF1040; cl01176 768492015206 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 768492015207 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 768492015208 GTP binding site; other site 768492015209 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 768492015210 Walker A motif; other site 768492015211 Transcriptional regulators [Transcription]; Region: FadR; COG2186 768492015212 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492015213 DNA-binding site [nucleotide binding]; DNA binding site 768492015214 FCD domain; Region: FCD; cl11656 768492015215 putative transporter; Provisional; Region: PRK10504 768492015216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492015217 putative substrate translocation pore; other site 768492015218 transcriptional repressor RbsR; Provisional; Region: PRK10423 768492015219 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492015220 DNA binding site [nucleotide binding] 768492015221 domain linker motif; other site 768492015222 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 768492015223 dimerization interface [polypeptide binding]; other site 768492015224 ligand binding site [chemical binding]; other site 768492015225 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768492015226 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 768492015227 substrate binding site [chemical binding]; other site 768492015228 dimer interface [polypeptide binding]; other site 768492015229 ATP binding site [chemical binding]; other site 768492015230 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 768492015231 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 768492015232 ligand binding site [chemical binding]; other site 768492015233 dimerization interface [polypeptide binding]; other site 768492015234 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768492015235 TM-ABC transporter signature motif; other site 768492015236 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 768492015237 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 768492015238 Walker A/P-loop; other site 768492015239 ATP binding site [chemical binding]; other site 768492015240 Q-loop/lid; other site 768492015241 ABC transporter signature motif; other site 768492015242 Walker B; other site 768492015243 D-loop; other site 768492015244 H-loop/switch region; other site 768492015245 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 768492015246 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 768492015247 K+ potassium transporter; Region: K_trans; cl15781 768492015248 potassium uptake protein; Region: kup; TIGR00794 768492015249 regulatory ATPase RavA; Provisional; Region: PRK13531 768492015250 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492015251 Walker A motif; other site 768492015252 ATP binding site [chemical binding]; other site 768492015253 Walker B motif; other site 768492015254 arginine finger; other site 768492015255 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 768492015256 hypothetical protein; Provisional; Region: yieM; PRK10997 768492015257 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 768492015258 metal ion-dependent adhesion site (MIDAS); other site 768492015259 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 768492015260 motif 1; other site 768492015261 dimer interface [polypeptide binding]; other site 768492015262 active site 768492015263 motif 2; other site 768492015264 motif 3; other site 768492015265 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 768492015266 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768492015267 dimerization interface [polypeptide binding]; other site 768492015268 putative DNA binding site [nucleotide binding]; other site 768492015269 putative Zn2+ binding site [ion binding]; other site 768492015270 AsnC family; Region: AsnC_trans_reg; pfam01037 768492015271 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 768492015272 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 768492015273 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492015274 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 768492015275 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492015276 S-adenosylmethionine binding site [chemical binding]; other site 768492015277 ATP synthase I chain; Region: ATP_synt_I; cl09170 768492015278 ATP synthase A chain; Region: ATP-synt_A; cl00413 768492015279 ATP synthase subunit C; Region: ATP-synt_C; cl00466 768492015280 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 768492015281 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 768492015282 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 768492015283 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 768492015284 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 768492015285 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 768492015286 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 768492015287 beta subunit interaction interface [polypeptide binding]; other site 768492015288 Walker A motif; other site 768492015289 ATP binding site [chemical binding]; other site 768492015290 Walker B motif; other site 768492015291 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 768492015292 ATP synthase; Region: ATP-synt; cl00365 768492015293 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 768492015294 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 768492015295 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 768492015296 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 768492015297 alpha subunit interaction interface [polypeptide binding]; other site 768492015298 Walker A motif; other site 768492015299 ATP binding site [chemical binding]; other site 768492015300 Walker B motif; other site 768492015301 inhibitor binding site; inhibition site 768492015302 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 768492015303 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 768492015304 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 768492015305 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 768492015306 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 768492015307 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 768492015308 Substrate binding site; other site 768492015309 Mg++ binding site; other site 768492015310 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 768492015311 active site 768492015312 substrate binding site [chemical binding]; other site 768492015313 CoA binding site [chemical binding]; other site 768492015314 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 768492015315 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 768492015316 glutaminase active site [active] 768492015317 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 768492015318 dimer interface [polypeptide binding]; other site 768492015319 active site 768492015320 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 768492015321 dimer interface [polypeptide binding]; other site 768492015322 active site 768492015323 AAA domain; Region: AAA_13; pfam13166 768492015324 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492015325 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492015326 dimer interface [polypeptide binding]; other site 768492015327 conserved gate region; other site 768492015328 putative PBP binding loops; other site 768492015329 ABC-ATPase subunit interface; other site 768492015330 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 768492015331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492015332 dimer interface [polypeptide binding]; other site 768492015333 conserved gate region; other site 768492015334 putative PBP binding loops; other site 768492015335 ABC-ATPase subunit interface; other site 768492015336 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 768492015337 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 768492015338 Walker A/P-loop; other site 768492015339 ATP binding site [chemical binding]; other site 768492015340 Q-loop/lid; other site 768492015341 ABC transporter signature motif; other site 768492015342 Walker B; other site 768492015343 D-loop; other site 768492015344 H-loop/switch region; other site 768492015345 transcriptional regulator PhoU; Provisional; Region: PRK11115 768492015346 PhoU domain; Region: PhoU; pfam01895 768492015347 PhoU domain; Region: PhoU; pfam01895 768492015348 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768492015349 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492015350 substrate binding pocket [chemical binding]; other site 768492015351 membrane-bound complex binding site; other site 768492015352 hinge residues; other site 768492015353 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492015354 dimer interface [polypeptide binding]; other site 768492015355 conserved gate region; other site 768492015356 putative PBP binding loops; other site 768492015357 ABC-ATPase subunit interface; other site 768492015358 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492015359 dimer interface [polypeptide binding]; other site 768492015360 conserved gate region; other site 768492015361 putative PBP binding loops; other site 768492015362 ABC-ATPase subunit interface; other site 768492015363 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 768492015364 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 768492015365 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 768492015366 Predicted esterase [General function prediction only]; Region: COG0400 768492015367 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 768492015368 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 768492015369 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 768492015370 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 768492015371 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 768492015372 trmE is a tRNA modification GTPase; Region: trmE; cd04164 768492015373 G1 box; other site 768492015374 GTP/Mg2+ binding site [chemical binding]; other site 768492015375 Switch I region; other site 768492015376 G2 box; other site 768492015377 Switch II region; other site 768492015378 G3 box; other site 768492015379 G4 box; other site 768492015380 G5 box; other site 768492015381 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 768492015382 membrane protein insertase; Provisional; Region: PRK01318 768492015383 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 768492015384 Haemolytic domain; Region: Haemolytic; cl00506 768492015385 Ribonuclease P; Region: Ribonuclease_P; cl00457 768492015386 Ribosomal protein L34; Region: Ribosomal_L34; cl00370