-- dump date 20140620_062435 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1346614000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1346614000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1346614000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1346614000004 Walker A motif; other site 1346614000005 ATP binding site [chemical binding]; other site 1346614000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1346614000007 Walker B motif; other site 1346614000008 arginine finger; other site 1346614000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1346614000010 DnaA box-binding interface [nucleotide binding]; other site 1346614000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 1346614000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1346614000013 putative DNA binding surface [nucleotide binding]; other site 1346614000014 dimer interface [polypeptide binding]; other site 1346614000015 beta-clamp/clamp loader binding surface; other site 1346614000016 beta-clamp/translesion DNA polymerase binding surface; other site 1346614000017 recF protein; Region: recf; TIGR00611 1346614000018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1346614000019 Walker A/P-loop; other site 1346614000020 ATP binding site [chemical binding]; other site 1346614000021 Q-loop/lid; other site 1346614000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1346614000023 ABC transporter signature motif; other site 1346614000024 Walker B; other site 1346614000025 D-loop; other site 1346614000026 H-loop/switch region; other site 1346614000027 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1346614000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614000029 Mg2+ binding site [ion binding]; other site 1346614000030 G-X-G motif; other site 1346614000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1346614000032 anchoring element; other site 1346614000033 dimer interface [polypeptide binding]; other site 1346614000034 ATP binding site [chemical binding]; other site 1346614000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1346614000036 active site 1346614000037 putative metal-binding site [ion binding]; other site 1346614000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1346614000039 sugar phosphate phosphatase; Provisional; Region: PRK10513 1346614000040 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1346614000041 active site 1346614000042 motif I; other site 1346614000043 motif II; other site 1346614000044 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1346614000045 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1346614000046 ornithine cyclodeaminase; Validated; Region: PRK06823 1346614000047 hypothetical protein; Provisional; Region: PRK06815 1346614000048 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1346614000049 tetramer interface [polypeptide binding]; other site 1346614000050 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614000051 catalytic residue [active] 1346614000052 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1346614000053 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1346614000054 DNA-binding site [nucleotide binding]; DNA binding site 1346614000055 FCD domain; Region: FCD; pfam07729 1346614000056 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 1346614000057 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 1346614000058 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 1346614000059 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1346614000060 active site 1346614000061 intersubunit interface [polypeptide binding]; other site 1346614000062 catalytic residue [active] 1346614000063 galactonate dehydratase; Provisional; Region: PRK14017 1346614000064 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 1346614000065 putative active site pocket [active] 1346614000066 putative metal binding site [ion binding]; other site 1346614000067 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614000068 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1346614000069 putative substrate translocation pore; other site 1346614000070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614000071 D-galactonate transporter; Region: 2A0114; TIGR00893 1346614000072 putative substrate translocation pore; other site 1346614000073 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 1346614000074 hypothetical protein; Provisional; Region: PRK11616 1346614000075 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1346614000076 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1346614000077 putative dimer interface [polypeptide binding]; other site 1346614000078 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1346614000079 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1346614000080 putative dimer interface [polypeptide binding]; other site 1346614000081 putative transporter; Validated; Region: PRK03818 1346614000082 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1346614000083 TrkA-C domain; Region: TrkA_C; pfam02080 1346614000084 TrkA-C domain; Region: TrkA_C; pfam02080 1346614000085 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1346614000086 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 1346614000087 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1346614000088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614000089 homodimer interface [polypeptide binding]; other site 1346614000090 catalytic residue [active] 1346614000091 alpha-amylase; Reviewed; Region: malS; PRK09505 1346614000092 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1346614000093 active site 1346614000094 catalytic site [active] 1346614000095 Predicted transcriptional regulator [Transcription]; Region: COG3905 1346614000096 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1346614000097 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1346614000098 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1346614000099 dimerization interface [polypeptide binding]; other site 1346614000100 ligand binding site [chemical binding]; other site 1346614000101 NADP binding site [chemical binding]; other site 1346614000102 catalytic site [active] 1346614000103 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614000104 D-galactonate transporter; Region: 2A0114; TIGR00893 1346614000105 putative substrate translocation pore; other site 1346614000106 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1346614000107 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1346614000108 substrate binding site [chemical binding]; other site 1346614000109 ATP binding site [chemical binding]; other site 1346614000110 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1346614000111 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1346614000112 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1346614000113 DNA binding site [nucleotide binding] 1346614000114 domain linker motif; other site 1346614000115 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1346614000116 putative dimerization interface [polypeptide binding]; other site 1346614000117 putative ligand binding site [chemical binding]; other site 1346614000118 putative outer membrane lipoprotein; Provisional; Region: PRK10510 1346614000119 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1346614000120 ligand binding site [chemical binding]; other site 1346614000121 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614000122 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1346614000123 Coenzyme A binding pocket [chemical binding]; other site 1346614000124 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1346614000125 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 1346614000126 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1346614000127 active site 1346614000128 catalytic triad [active] 1346614000129 oxyanion hole [active] 1346614000130 Autotransporter beta-domain; Region: Autotransporter; cl17461 1346614000131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614000132 D-galactonate transporter; Region: 2A0114; TIGR00893 1346614000133 putative substrate translocation pore; other site 1346614000134 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1346614000135 dimer interface [polypeptide binding]; other site 1346614000136 motif 1; other site 1346614000137 active site 1346614000138 motif 2; other site 1346614000139 motif 3; other site 1346614000140 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1346614000141 DALR anticodon binding domain; Region: DALR_1; pfam05746 1346614000142 Fic family protein [Function unknown]; Region: COG3177 1346614000143 Fic/DOC family; Region: Fic; pfam02661 1346614000144 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 1346614000145 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 1346614000146 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1346614000147 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1346614000148 active site 1346614000149 P-loop; other site 1346614000150 phosphorylation site [posttranslational modification] 1346614000151 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1346614000152 active site 1346614000153 phosphorylation site [posttranslational modification] 1346614000154 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1346614000155 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1346614000156 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1346614000157 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 1346614000158 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 1346614000159 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1346614000160 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1346614000161 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1346614000162 DNA-binding site [nucleotide binding]; DNA binding site 1346614000163 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1346614000164 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614000165 homodimer interface [polypeptide binding]; other site 1346614000166 catalytic residue [active] 1346614000167 hypothetical protein; Provisional; Region: PRK11020 1346614000168 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614000169 S-adenosylmethionine binding site [chemical binding]; other site 1346614000170 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 1346614000171 MOSC domain; Region: MOSC; pfam03473 1346614000172 3-alpha domain; Region: 3-alpha; pfam03475 1346614000173 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1346614000174 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1346614000175 dimerization interface [polypeptide binding]; other site 1346614000176 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1346614000177 dimer interface [polypeptide binding]; other site 1346614000178 putative CheW interface [polypeptide binding]; other site 1346614000179 superoxide dismutase; Provisional; Region: PRK10925 1346614000180 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1346614000181 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1346614000182 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1346614000183 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1346614000184 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1346614000185 molybdopterin cofactor binding site; other site 1346614000186 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1346614000187 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1346614000188 molybdopterin cofactor binding site; other site 1346614000189 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1346614000190 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1346614000191 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 1346614000192 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1346614000193 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 1346614000194 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1346614000195 hypothetical protein; Provisional; Region: PRK11615 1346614000196 putative glutathione S-transferase; Provisional; Region: PRK10357 1346614000197 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1346614000198 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1346614000199 dimer interface [polypeptide binding]; other site 1346614000200 N-terminal domain interface [polypeptide binding]; other site 1346614000201 putative substrate binding pocket (H-site) [chemical binding]; other site 1346614000202 selenocysteine synthase; Provisional; Region: PRK04311 1346614000203 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 1346614000204 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 1346614000205 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1346614000206 catalytic residue [active] 1346614000207 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 1346614000208 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1346614000209 G1 box; other site 1346614000210 putative GEF interaction site [polypeptide binding]; other site 1346614000211 GTP/Mg2+ binding site [chemical binding]; other site 1346614000212 Switch I region; other site 1346614000213 G2 box; other site 1346614000214 G3 box; other site 1346614000215 Switch II region; other site 1346614000216 G4 box; other site 1346614000217 G5 box; other site 1346614000218 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1346614000219 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 1346614000220 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 1346614000221 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1346614000222 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 1346614000223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614000224 putative substrate translocation pore; other site 1346614000225 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1346614000226 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1346614000227 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1346614000228 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1346614000229 conserved cys residue [active] 1346614000230 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614000231 Isochorismatase family; Region: Isochorismatase; pfam00857 1346614000232 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1346614000233 catalytic triad [active] 1346614000234 conserved cis-peptide bond; other site 1346614000235 putative deaminase; Validated; Region: PRK06846 1346614000236 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1346614000237 active site 1346614000238 xylose isomerase; Provisional; Region: PRK05474 1346614000239 xylose isomerase; Region: xylose_isom_A; TIGR02630 1346614000240 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 1346614000241 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1346614000242 putative ligand binding site [chemical binding]; other site 1346614000243 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 1346614000244 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1346614000245 Walker A/P-loop; other site 1346614000246 ATP binding site [chemical binding]; other site 1346614000247 Q-loop/lid; other site 1346614000248 ABC transporter signature motif; other site 1346614000249 Walker B; other site 1346614000250 D-loop; other site 1346614000251 H-loop/switch region; other site 1346614000252 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1346614000253 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism]; Region: AraH; COG1172 1346614000254 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1346614000255 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1346614000256 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1346614000257 TM-ABC transporter signature motif; other site 1346614000258 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 1346614000259 putative dimerization interface [polypeptide binding]; other site 1346614000260 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1346614000261 putative ligand binding site [chemical binding]; other site 1346614000262 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614000263 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1346614000264 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614000265 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1346614000266 dimerization interface [polypeptide binding]; other site 1346614000267 putative DNA binding site [nucleotide binding]; other site 1346614000268 putative Zn2+ binding site [ion binding]; other site 1346614000269 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1346614000270 active site 1346614000271 NTP binding site [chemical binding]; other site 1346614000272 metal binding triad [ion binding]; metal-binding site 1346614000273 antibiotic binding site [chemical binding]; other site 1346614000274 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614000275 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1346614000276 dimerization interface [polypeptide binding]; other site 1346614000277 putative cyanate transporter; Provisional; Region: cynX; PRK09705 1346614000278 Herpesvirus U59 protein; Region: Herpes_U59; pfam04529 1346614000279 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 1346614000280 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1346614000281 active site 1346614000282 NTP binding site [chemical binding]; other site 1346614000283 metal binding triad [ion binding]; metal-binding site 1346614000284 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1346614000285 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1346614000286 DNA binding residues [nucleotide binding] 1346614000287 dimerization interface [polypeptide binding]; other site 1346614000288 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1346614000289 catalytic core [active] 1346614000290 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 1346614000291 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1346614000292 nucleotide binding site/active site [active] 1346614000293 HIT family signature motif; other site 1346614000294 catalytic residue [active] 1346614000295 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1346614000296 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1346614000297 DNA binding site [nucleotide binding] 1346614000298 domain linker motif; other site 1346614000299 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 1346614000300 putative dimerization interface [polypeptide binding]; other site 1346614000301 putative ligand binding site [chemical binding]; other site 1346614000302 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1346614000303 classical (c) SDRs; Region: SDR_c; cd05233 1346614000304 NAD(P) binding site [chemical binding]; other site 1346614000305 active site 1346614000306 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1346614000307 DctM-like transporters; Region: DctM; pfam06808 1346614000308 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1346614000309 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1346614000310 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1346614000311 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1346614000312 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1346614000313 extended (e) SDRs; Region: SDR_e; cd08946 1346614000314 NAD(P) binding site [chemical binding]; other site 1346614000315 active site 1346614000316 substrate binding site [chemical binding]; other site 1346614000317 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614000318 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614000319 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1346614000320 dimerization interface [polypeptide binding]; other site 1346614000321 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1346614000322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1346614000323 NAD(P) binding site [chemical binding]; other site 1346614000324 active site 1346614000325 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 1346614000326 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1346614000327 active site turn [active] 1346614000328 phosphorylation site [posttranslational modification] 1346614000329 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1346614000330 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1346614000331 HPr interaction site; other site 1346614000332 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1346614000333 active site 1346614000334 phosphorylation site [posttranslational modification] 1346614000335 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1346614000336 beta-galactosidase; Region: BGL; TIGR03356 1346614000337 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1346614000338 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1346614000339 HD domain; Region: HD_4; pfam13328 1346614000340 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1346614000341 MarR family; Region: MarR; pfam01047 1346614000342 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1346614000343 phosphoethanolamine transferase; Provisional; Region: PRK11560 1346614000344 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1346614000345 Sulfatase; Region: Sulfatase; pfam00884 1346614000346 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 1346614000347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614000348 active site 1346614000349 phosphorylation site [posttranslational modification] 1346614000350 intermolecular recognition site; other site 1346614000351 dimerization interface [polypeptide binding]; other site 1346614000352 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1346614000353 DNA binding residues [nucleotide binding] 1346614000354 dimerization interface [polypeptide binding]; other site 1346614000355 sensory histidine kinase UhpB; Provisional; Region: PRK11644 1346614000356 MASE1; Region: MASE1; pfam05231 1346614000357 Histidine kinase; Region: HisKA_3; pfam07730 1346614000358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614000359 ATP binding site [chemical binding]; other site 1346614000360 Mg2+ binding site [ion binding]; other site 1346614000361 G-X-G motif; other site 1346614000362 regulatory protein UhpC; Provisional; Region: PRK11663 1346614000363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614000364 putative substrate translocation pore; other site 1346614000365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614000366 Predicted transcriptional regulator [Transcription]; Region: COG4190 1346614000367 MarR family; Region: MarR_2; cl17246 1346614000368 N-terminal Early set domain associated with the catalytic domain of chitinase; Region: E_set_Chitinase_N; cd02848 1346614000369 Glyco_18 domain; Region: Glyco_18; smart00636 1346614000370 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1346614000371 active site 1346614000372 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1346614000373 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1346614000374 peptide binding site [polypeptide binding]; other site 1346614000375 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1346614000376 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614000377 dimer interface [polypeptide binding]; other site 1346614000378 conserved gate region; other site 1346614000379 putative PBP binding loops; other site 1346614000380 ABC-ATPase subunit interface; other site 1346614000381 dipeptide transporter; Provisional; Region: PRK10913 1346614000382 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1346614000383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614000384 dimer interface [polypeptide binding]; other site 1346614000385 conserved gate region; other site 1346614000386 putative PBP binding loops; other site 1346614000387 ABC-ATPase subunit interface; other site 1346614000388 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 1346614000389 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1346614000390 Walker A/P-loop; other site 1346614000391 ATP binding site [chemical binding]; other site 1346614000392 Q-loop/lid; other site 1346614000393 ABC transporter signature motif; other site 1346614000394 Walker B; other site 1346614000395 D-loop; other site 1346614000396 H-loop/switch region; other site 1346614000397 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1346614000398 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1346614000399 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1346614000400 Walker A/P-loop; other site 1346614000401 ATP binding site [chemical binding]; other site 1346614000402 Q-loop/lid; other site 1346614000403 ABC transporter signature motif; other site 1346614000404 Walker B; other site 1346614000405 D-loop; other site 1346614000406 H-loop/switch region; other site 1346614000407 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1346614000408 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 1346614000409 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 1346614000410 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 1346614000411 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 1346614000412 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 1346614000413 YhjQ protein; Region: YhjQ; pfam06564 1346614000414 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1346614000415 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 1346614000416 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1346614000417 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1346614000418 DXD motif; other site 1346614000419 PilZ domain; Region: PilZ; pfam07238 1346614000420 cellulose synthase regulator protein; Provisional; Region: PRK11114 1346614000421 endo-1,4-D-glucanase; Provisional; Region: PRK11097 1346614000422 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 1346614000423 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1346614000424 TPR motif; other site 1346614000425 binding surface 1346614000426 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1346614000427 TPR motif; other site 1346614000428 binding surface 1346614000429 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1346614000430 TPR motif; other site 1346614000431 binding surface 1346614000432 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 1346614000433 putative diguanylate cyclase; Provisional; Region: PRK13561 1346614000434 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1346614000435 metal binding site [ion binding]; metal-binding site 1346614000436 active site 1346614000437 I-site; other site 1346614000438 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1346614000439 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1346614000440 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1346614000441 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1346614000442 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1346614000443 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1346614000444 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1346614000445 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1346614000446 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 1346614000447 Part of AAA domain; Region: AAA_19; pfam13245 1346614000448 Family description; Region: UvrD_C_2; pfam13538 1346614000449 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 1346614000450 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1346614000451 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1346614000452 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1346614000453 ATP binding site [chemical binding]; other site 1346614000454 Mg++ binding site [ion binding]; other site 1346614000455 motif III; other site 1346614000456 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1346614000457 nucleotide binding region [chemical binding]; other site 1346614000458 ATP-binding site [chemical binding]; other site 1346614000459 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1346614000460 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1346614000461 catalytic residues [active] 1346614000462 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1346614000463 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1346614000464 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1346614000465 RNA binding site [nucleotide binding]; other site 1346614000466 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1346614000467 multimer interface [polypeptide binding]; other site 1346614000468 Walker A motif; other site 1346614000469 ATP binding site [chemical binding]; other site 1346614000470 Walker B motif; other site 1346614000471 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 1346614000472 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1346614000473 Mg++ binding site [ion binding]; other site 1346614000474 putative catalytic motif [active] 1346614000475 substrate binding site [chemical binding]; other site 1346614000476 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 1346614000477 Chain length determinant protein; Region: Wzz; cl15801 1346614000478 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1346614000479 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1346614000480 active site 1346614000481 homodimer interface [polypeptide binding]; other site 1346614000482 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 1346614000483 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1346614000484 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1346614000485 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1346614000486 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 1346614000487 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1346614000488 NAD binding site [chemical binding]; other site 1346614000489 substrate binding site [chemical binding]; other site 1346614000490 homodimer interface [polypeptide binding]; other site 1346614000491 active site 1346614000492 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1346614000493 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1346614000494 substrate binding site; other site 1346614000495 tetramer interface; other site 1346614000496 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1346614000497 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614000498 Coenzyme A binding pocket [chemical binding]; other site 1346614000499 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1346614000500 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1346614000501 inhibitor-cofactor binding pocket; inhibition site 1346614000502 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614000503 catalytic residue [active] 1346614000504 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1346614000505 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 1346614000506 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 1346614000507 putative common antigen polymerase; Provisional; Region: PRK02975 1346614000508 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1346614000509 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1346614000510 putative transport protein YifK; Provisional; Region: PRK10746 1346614000511 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 1346614000512 HemY protein N-terminus; Region: HemY_N; pfam07219 1346614000513 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1346614000514 TPR motif; other site 1346614000515 binding surface 1346614000516 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1346614000517 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 1346614000518 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1346614000519 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1346614000520 active site 1346614000521 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1346614000522 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1346614000523 domain interfaces; other site 1346614000524 active site 1346614000525 adenylate cyclase; Provisional; Region: cyaA; PRK09450 1346614000526 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 1346614000527 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 1346614000528 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 1346614000529 putative iron binding site [ion binding]; other site 1346614000530 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 1346614000531 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1346614000532 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1346614000533 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1346614000534 hypothetical protein; Provisional; Region: PRK10963 1346614000535 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 1346614000536 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1346614000537 active site 1346614000538 DNA binding site [nucleotide binding] 1346614000539 Int/Topo IB signature motif; other site 1346614000540 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 1346614000541 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1346614000542 motif II; other site 1346614000543 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1346614000544 Part of AAA domain; Region: AAA_19; pfam13245 1346614000545 Family description; Region: UvrD_C_2; pfam13538 1346614000546 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 1346614000547 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 1346614000548 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1346614000549 oligomer interface [polypeptide binding]; other site 1346614000550 Cl binding site [ion binding]; other site 1346614000551 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1346614000552 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1346614000553 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1346614000554 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 1346614000555 EamA-like transporter family; Region: EamA; cl17759 1346614000556 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1346614000557 CoenzymeA binding site [chemical binding]; other site 1346614000558 subunit interaction site [polypeptide binding]; other site 1346614000559 PHB binding site; other site 1346614000560 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 1346614000561 dimerization interface [polypeptide binding]; other site 1346614000562 substrate binding site [chemical binding]; other site 1346614000563 active site 1346614000564 calcium binding site [ion binding]; other site 1346614000565 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 1346614000566 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1346614000567 ATP binding site [chemical binding]; other site 1346614000568 putative Mg++ binding site [ion binding]; other site 1346614000569 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1346614000570 nucleotide binding region [chemical binding]; other site 1346614000571 ATP-binding site [chemical binding]; other site 1346614000572 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1346614000573 HRDC domain; Region: HRDC; pfam00570 1346614000574 threonine efflux system; Provisional; Region: PRK10229 1346614000575 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 1346614000576 lysophospholipase L2; Provisional; Region: PRK10749 1346614000577 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1346614000578 putative hydrolase; Provisional; Region: PRK10976 1346614000579 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1346614000580 active site 1346614000581 motif I; other site 1346614000582 motif II; other site 1346614000583 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1346614000584 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 1346614000585 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 1346614000586 active site 1346614000587 catalytic site [active] 1346614000588 metal binding site [ion binding]; metal-binding site 1346614000589 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1346614000590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614000591 putative substrate translocation pore; other site 1346614000592 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 1346614000593 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1346614000594 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1346614000595 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 1346614000596 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1346614000597 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 1346614000598 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1346614000599 Cysteine-rich domain; Region: CCG; pfam02754 1346614000600 Cysteine-rich domain; Region: CCG; pfam02754 1346614000601 hypothetical protein; Provisional; Region: PRK11615 1346614000602 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614000603 Coenzyme A binding pocket [chemical binding]; other site 1346614000604 hypothetical protein; Provisional; Region: PRK11212 1346614000605 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 1346614000606 CPxP motif; other site 1346614000607 Protein of unknown function (DUF4056); Region: DUF4056; pfam13265 1346614000608 Surface antigen; Region: Bac_surface_Ag; pfam01103 1346614000609 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1346614000610 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 1346614000611 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1346614000612 metal-binding site [ion binding] 1346614000613 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1346614000614 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1346614000615 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 1346614000616 active site 1346614000617 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1346614000618 Protease inhibitor Inh; Region: Inh; pfam02974 1346614000619 Predicted membrane protein [Function unknown]; Region: COG3714 1346614000620 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1346614000621 active site 1346614000622 DNA binding site [nucleotide binding] 1346614000623 Int/Topo IB signature motif; other site 1346614000624 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 1346614000625 DNA binding residues [nucleotide binding] 1346614000626 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1346614000627 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1346614000628 dimerization interface [polypeptide binding]; other site 1346614000629 DNA binding residues [nucleotide binding] 1346614000630 Protein of unknown function (DUF1401); Region: DUF1401; pfam07180 1346614000631 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1346614000632 active site 1346614000633 DNA binding site [nucleotide binding] 1346614000634 Int/Topo IB signature motif; other site 1346614000635 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1346614000636 DNA binding residues [nucleotide binding] 1346614000637 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1346614000638 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1346614000639 DNA binding residues [nucleotide binding] 1346614000640 dimerization interface [polypeptide binding]; other site 1346614000641 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 1346614000642 hypothetical protein; Provisional; Region: PRK10910 1346614000643 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1346614000644 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614000645 S-adenosylmethionine binding site [chemical binding]; other site 1346614000646 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1346614000647 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1346614000648 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1346614000649 P loop; other site 1346614000650 GTP binding site [chemical binding]; other site 1346614000651 cell division protein FtsE; Provisional; Region: PRK10908 1346614000652 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1346614000653 Walker A/P-loop; other site 1346614000654 ATP binding site [chemical binding]; other site 1346614000655 Q-loop/lid; other site 1346614000656 ABC transporter signature motif; other site 1346614000657 Walker B; other site 1346614000658 D-loop; other site 1346614000659 H-loop/switch region; other site 1346614000660 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1346614000661 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 1346614000662 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1346614000663 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1346614000664 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1346614000665 DNA binding residues [nucleotide binding] 1346614000666 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 1346614000667 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 1346614000668 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1346614000669 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1346614000670 dimerization interface [polypeptide binding]; other site 1346614000671 ligand binding site [chemical binding]; other site 1346614000672 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1346614000673 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1346614000674 TM-ABC transporter signature motif; other site 1346614000675 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1346614000676 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1346614000677 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1346614000678 TM-ABC transporter signature motif; other site 1346614000679 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1346614000680 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1346614000681 Walker A/P-loop; other site 1346614000682 ATP binding site [chemical binding]; other site 1346614000683 Q-loop/lid; other site 1346614000684 ABC transporter signature motif; other site 1346614000685 Walker B; other site 1346614000686 D-loop; other site 1346614000687 H-loop/switch region; other site 1346614000688 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 1346614000689 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1346614000690 Walker A/P-loop; other site 1346614000691 ATP binding site [chemical binding]; other site 1346614000692 Q-loop/lid; other site 1346614000693 ABC transporter signature motif; other site 1346614000694 Walker B; other site 1346614000695 D-loop; other site 1346614000696 H-loop/switch region; other site 1346614000697 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1346614000698 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1346614000699 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614000700 homodimer interface [polypeptide binding]; other site 1346614000701 catalytic residue [active] 1346614000702 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1346614000703 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 1346614000704 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1346614000705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614000706 dimer interface [polypeptide binding]; other site 1346614000707 conserved gate region; other site 1346614000708 putative PBP binding loops; other site 1346614000709 ABC-ATPase subunit interface; other site 1346614000710 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1346614000711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614000712 dimer interface [polypeptide binding]; other site 1346614000713 conserved gate region; other site 1346614000714 putative PBP binding loops; other site 1346614000715 ABC-ATPase subunit interface; other site 1346614000716 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 1346614000717 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1346614000718 putative active site [active] 1346614000719 catalytic site [active] 1346614000720 putative metal binding site [ion binding]; other site 1346614000721 Predicted permeases [General function prediction only]; Region: COG0679 1346614000722 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1346614000723 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1346614000724 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614000725 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1346614000726 putative dimerization interface [polypeptide binding]; other site 1346614000727 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1346614000728 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1346614000729 THF binding site; other site 1346614000730 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1346614000731 substrate binding site [chemical binding]; other site 1346614000732 THF binding site; other site 1346614000733 zinc-binding site [ion binding]; other site 1346614000734 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1346614000735 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1346614000736 uridine phosphorylase; Provisional; Region: PRK11178 1346614000737 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 1346614000738 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1346614000739 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1346614000740 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1346614000741 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1346614000742 DNA recombination protein RmuC; Provisional; Region: PRK10361 1346614000743 RmuC family; Region: RmuC; pfam02646 1346614000744 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1346614000745 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614000746 S-adenosylmethionine binding site [chemical binding]; other site 1346614000747 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1346614000748 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1346614000749 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 1346614000750 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1346614000751 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1346614000752 sec-independent translocase; Provisional; Region: PRK01770 1346614000753 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 1346614000754 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1346614000755 active site 1346614000756 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 1346614000757 dimer interface [polypeptide binding]; other site 1346614000758 allosteric magnesium binding site [ion binding]; other site 1346614000759 active site 1346614000760 aspartate-rich active site metal binding site; other site 1346614000761 Schiff base residues; other site 1346614000762 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 1346614000763 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 1346614000764 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1346614000765 active site pocket [active] 1346614000766 oxyanion hole [active] 1346614000767 catalytic triad [active] 1346614000768 active site nucleophile [active] 1346614000769 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 1346614000770 FMN reductase; Validated; Region: fre; PRK08051 1346614000771 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1346614000772 FAD binding pocket [chemical binding]; other site 1346614000773 FAD binding motif [chemical binding]; other site 1346614000774 phosphate binding motif [ion binding]; other site 1346614000775 beta-alpha-beta structure motif; other site 1346614000776 NAD binding pocket [chemical binding]; other site 1346614000777 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 1346614000778 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1346614000779 dimer interface [polypeptide binding]; other site 1346614000780 active site 1346614000781 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1346614000782 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1346614000783 substrate binding site [chemical binding]; other site 1346614000784 oxyanion hole (OAH) forming residues; other site 1346614000785 trimer interface [polypeptide binding]; other site 1346614000786 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1346614000787 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1346614000788 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1346614000789 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614000790 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1346614000791 putative substrate translocation pore; other site 1346614000792 proline dipeptidase; Provisional; Region: PRK13607 1346614000793 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1346614000794 active site 1346614000795 hypothetical protein; Provisional; Region: PRK11568 1346614000796 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1346614000797 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1346614000798 potassium transporter; Provisional; Region: PRK10750 1346614000799 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1346614000800 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 1346614000801 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1346614000802 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1346614000803 Na binding site [ion binding]; other site 1346614000804 Predicted membrane protein [Function unknown]; Region: COG3162 1346614000805 acetyl-CoA synthetase; Provisional; Region: PRK00174 1346614000806 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1346614000807 active site 1346614000808 CoA binding site [chemical binding]; other site 1346614000809 acyl-activating enzyme (AAE) consensus motif; other site 1346614000810 AMP binding site [chemical binding]; other site 1346614000811 acetate binding site [chemical binding]; other site 1346614000812 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1346614000813 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1346614000814 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1346614000815 Peptidase family M23; Region: Peptidase_M23; pfam01551 1346614000816 Predicted membrane protein (DUF2238); Region: DUF2238; cl01464 1346614000817 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1346614000818 Fimbrial protein; Region: Fimbrial; pfam00419 1346614000819 Fimbrial protein; Region: Fimbrial; cl01416 1346614000820 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cl07688 1346614000821 mannosyl binding site [chemical binding]; other site 1346614000822 Fimbrial protein; Region: Fimbrial; pfam00419 1346614000823 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1346614000824 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 1346614000825 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1346614000826 molybdopterin cofactor binding site [chemical binding]; other site 1346614000827 substrate binding site [chemical binding]; other site 1346614000828 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1346614000829 molybdopterin cofactor binding site; other site 1346614000830 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 1346614000831 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1346614000832 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 1346614000833 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 1346614000834 putative ligand binding site [chemical binding]; other site 1346614000835 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 1346614000836 HAMP domain; Region: HAMP; pfam00672 1346614000837 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1346614000838 dimer interface [polypeptide binding]; other site 1346614000839 phosphorylation site [posttranslational modification] 1346614000840 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614000841 ATP binding site [chemical binding]; other site 1346614000842 Mg2+ binding site [ion binding]; other site 1346614000843 G-X-G motif; other site 1346614000844 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614000845 active site 1346614000846 phosphorylation site [posttranslational modification] 1346614000847 intermolecular recognition site; other site 1346614000848 dimerization interface [polypeptide binding]; other site 1346614000849 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1346614000850 putative binding surface; other site 1346614000851 active site 1346614000852 putative transcriptional regulator; Provisional; Region: PRK11640 1346614000853 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1346614000854 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1346614000855 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1346614000856 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1346614000857 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1346614000858 DsbD alpha interface [polypeptide binding]; other site 1346614000859 catalytic residues [active] 1346614000860 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 1346614000861 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1346614000862 Aspartase; Region: Aspartase; cd01357 1346614000863 active sites [active] 1346614000864 tetramer interface [polypeptide binding]; other site 1346614000865 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 1346614000866 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1346614000867 oligomerisation interface [polypeptide binding]; other site 1346614000868 mobile loop; other site 1346614000869 roof hairpin; other site 1346614000870 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1346614000871 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1346614000872 ring oligomerisation interface [polypeptide binding]; other site 1346614000873 ATP/Mg binding site [chemical binding]; other site 1346614000874 stacking interactions; other site 1346614000875 hinge regions; other site 1346614000876 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 1346614000877 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1346614000878 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1346614000879 FeS/SAM binding site; other site 1346614000880 elongation factor P; Validated; Region: PRK00529 1346614000881 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1346614000882 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1346614000883 RNA binding site [nucleotide binding]; other site 1346614000884 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1346614000885 RNA binding site [nucleotide binding]; other site 1346614000886 Predicted small secreted protein [Function unknown]; Region: COG5510 1346614000887 multidrug efflux system protein; Provisional; Region: PRK11431 1346614000888 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 1346614000889 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1346614000890 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 1346614000891 Iron-sulfur protein interface; other site 1346614000892 proximal quinone binding site [chemical binding]; other site 1346614000893 C-subunit interface; other site 1346614000894 distal quinone binding site; other site 1346614000895 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 1346614000896 D-subunit interface [polypeptide binding]; other site 1346614000897 Iron-sulfur protein interface; other site 1346614000898 proximal quinone binding site [chemical binding]; other site 1346614000899 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 1346614000900 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1346614000901 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 1346614000902 L-aspartate oxidase; Provisional; Region: PRK06175 1346614000903 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1346614000904 poxB regulator PoxA; Provisional; Region: PRK09350 1346614000905 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1346614000906 motif 1; other site 1346614000907 dimer interface [polypeptide binding]; other site 1346614000908 active site 1346614000909 motif 2; other site 1346614000910 motif 3; other site 1346614000911 putative mechanosensitive channel protein; Provisional; Region: PRK10929 1346614000912 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1346614000913 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1346614000914 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1346614000915 GTPase RsgA; Reviewed; Region: PRK12288 1346614000916 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1346614000917 RNA binding site [nucleotide binding]; other site 1346614000918 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1346614000919 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1346614000920 GTP/Mg2+ binding site [chemical binding]; other site 1346614000921 G4 box; other site 1346614000922 G5 box; other site 1346614000923 G1 box; other site 1346614000924 Switch I region; other site 1346614000925 G2 box; other site 1346614000926 G3 box; other site 1346614000927 Switch II region; other site 1346614000928 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1346614000929 catalytic site [active] 1346614000930 putative active site [active] 1346614000931 putative substrate binding site [chemical binding]; other site 1346614000932 dimer interface [polypeptide binding]; other site 1346614000933 epoxyqueuosine reductase; Region: TIGR00276 1346614000934 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1346614000935 putative carbohydrate kinase; Provisional; Region: PRK10565 1346614000936 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1346614000937 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1346614000938 putative substrate binding site [chemical binding]; other site 1346614000939 putative ATP binding site [chemical binding]; other site 1346614000940 ADP-binding protein; Provisional; Region: PRK10646 1346614000941 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 1346614000942 AMIN domain; Region: AMIN; pfam11741 1346614000943 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1346614000944 active site 1346614000945 metal binding site [ion binding]; metal-binding site 1346614000946 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1346614000947 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1346614000948 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1346614000949 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614000950 ATP binding site [chemical binding]; other site 1346614000951 Mg2+ binding site [ion binding]; other site 1346614000952 G-X-G motif; other site 1346614000953 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1346614000954 ATP binding site [chemical binding]; other site 1346614000955 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1346614000956 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1346614000957 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1346614000958 bacterial Hfq-like; Region: Hfq; cd01716 1346614000959 hexamer interface [polypeptide binding]; other site 1346614000960 Sm1 motif; other site 1346614000961 RNA binding site [nucleotide binding]; other site 1346614000962 Sm2 motif; other site 1346614000963 GTPase HflX; Provisional; Region: PRK11058 1346614000964 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1346614000965 HflX GTPase family; Region: HflX; cd01878 1346614000966 G1 box; other site 1346614000967 GTP/Mg2+ binding site [chemical binding]; other site 1346614000968 Switch I region; other site 1346614000969 G2 box; other site 1346614000970 G3 box; other site 1346614000971 Switch II region; other site 1346614000972 G4 box; other site 1346614000973 G5 box; other site 1346614000974 FtsH protease regulator HflK; Provisional; Region: PRK10930 1346614000975 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 1346614000976 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1346614000977 FtsH protease regulator HflC; Provisional; Region: PRK11029 1346614000978 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1346614000979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 1346614000980 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1346614000981 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1346614000982 GDP-binding site [chemical binding]; other site 1346614000983 ACT binding site; other site 1346614000984 IMP binding site; other site 1346614000985 Predicted transcriptional regulator [Transcription]; Region: COG1959 1346614000986 transcriptional repressor NsrR; Provisional; Region: PRK11014 1346614000987 exoribonuclease R; Provisional; Region: PRK11642 1346614000988 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 1346614000989 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1346614000990 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1346614000991 RNB domain; Region: RNB; pfam00773 1346614000992 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1346614000993 RNA binding site [nucleotide binding]; other site 1346614000994 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1346614000995 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1346614000996 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1346614000997 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1346614000998 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 1346614000999 FAD binding site [chemical binding]; other site 1346614001000 substrate binding site [chemical binding]; other site 1346614001001 catalytic residues [active] 1346614001002 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1346614001003 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1346614001004 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1346614001005 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 1346614001006 esterase; Provisional; Region: PRK10566 1346614001007 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1346614001008 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1346614001009 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1346614001010 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1346614001011 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1346614001012 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1346614001013 Protein of unknown function, DUF488; Region: DUF488; cl01246 1346614001014 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 1346614001015 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 1346614001016 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 1346614001017 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1346614001018 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1346614001019 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 1346614001020 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1346614001021 Hemerythrin-like domain; Region: Hr-like; cd12108 1346614001022 Fe binding site [ion binding]; other site 1346614001023 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 1346614001024 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1346614001025 active site 1346614001026 metal binding site [ion binding]; metal-binding site 1346614001027 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1346614001028 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1346614001029 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1346614001030 active site 1346614001031 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 1346614001032 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 1346614001033 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1346614001034 Domain of unknown function DUF21; Region: DUF21; pfam01595 1346614001035 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1346614001036 Transporter associated domain; Region: CorC_HlyC; smart01091 1346614001037 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1346614001038 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1346614001039 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1346614001040 Surface antigen; Region: Bac_surface_Ag; pfam01103 1346614001041 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1346614001042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1346614001043 Family of unknown function (DUF490); Region: DUF490; pfam04357 1346614001044 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1346614001045 dimerization interface [polypeptide binding]; other site 1346614001046 putative active site pocket [active] 1346614001047 putative catalytic residue [active] 1346614001048 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1346614001049 dimer interface [polypeptide binding]; other site 1346614001050 substrate binding site [chemical binding]; other site 1346614001051 metal binding sites [ion binding]; metal-binding site 1346614001052 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1346614001053 ligand binding site [chemical binding]; other site 1346614001054 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1346614001055 dimerization interface [polypeptide binding]; other site 1346614001056 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1346614001057 dimer interface [polypeptide binding]; other site 1346614001058 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1346614001059 putative CheW interface [polypeptide binding]; other site 1346614001060 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1346614001061 AMP binding site [chemical binding]; other site 1346614001062 metal binding site [ion binding]; metal-binding site 1346614001063 active site 1346614001064 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1346614001065 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1346614001066 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1346614001067 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1346614001068 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1346614001069 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1346614001070 arginine repressor; Provisional; Region: PRK05066 1346614001071 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1346614001072 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1346614001073 malate dehydrogenase; Provisional; Region: PRK05086 1346614001074 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 1346614001075 NAD binding site [chemical binding]; other site 1346614001076 dimerization interface [polypeptide binding]; other site 1346614001077 Substrate binding site [chemical binding]; other site 1346614001078 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 1346614001079 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 1346614001080 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1346614001081 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1346614001082 substrate binding pocket [chemical binding]; other site 1346614001083 chain length determination region; other site 1346614001084 substrate-Mg2+ binding site; other site 1346614001085 catalytic residues [active] 1346614001086 aspartate-rich region 1; other site 1346614001087 active site lid residues [active] 1346614001088 aspartate-rich region 2; other site 1346614001089 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1346614001090 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1346614001091 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1346614001092 EamA-like transporter family; Region: EamA; pfam00892 1346614001093 EamA-like transporter family; Region: EamA; pfam00892 1346614001094 GTPase CgtA; Reviewed; Region: obgE; PRK12298 1346614001095 GTP1/OBG; Region: GTP1_OBG; pfam01018 1346614001096 Obg GTPase; Region: Obg; cd01898 1346614001097 G1 box; other site 1346614001098 GTP/Mg2+ binding site [chemical binding]; other site 1346614001099 Switch I region; other site 1346614001100 G2 box; other site 1346614001101 G3 box; other site 1346614001102 Switch II region; other site 1346614001103 G4 box; other site 1346614001104 G5 box; other site 1346614001105 sensor protein BasS/PmrB; Provisional; Region: PRK10755 1346614001106 HAMP domain; Region: HAMP; pfam00672 1346614001107 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1346614001108 dimer interface [polypeptide binding]; other site 1346614001109 phosphorylation site [posttranslational modification] 1346614001110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614001111 ATP binding site [chemical binding]; other site 1346614001112 Mg2+ binding site [ion binding]; other site 1346614001113 G-X-G motif; other site 1346614001114 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1346614001115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614001116 active site 1346614001117 phosphorylation site [posttranslational modification] 1346614001118 intermolecular recognition site; other site 1346614001119 dimerization interface [polypeptide binding]; other site 1346614001120 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1346614001121 DNA binding site [nucleotide binding] 1346614001122 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 1346614001123 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1346614001124 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1346614001125 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1346614001126 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1346614001127 RNA-binding protein YhbY; Provisional; Region: PRK10343 1346614001128 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1346614001129 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614001130 S-adenosylmethionine binding site [chemical binding]; other site 1346614001131 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 1346614001132 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1346614001133 Walker A motif; other site 1346614001134 ATP binding site [chemical binding]; other site 1346614001135 Walker B motif; other site 1346614001136 arginine finger; other site 1346614001137 Peptidase family M41; Region: Peptidase_M41; pfam01434 1346614001138 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1346614001139 dihydropteroate synthase; Region: DHPS; TIGR01496 1346614001140 substrate binding pocket [chemical binding]; other site 1346614001141 dimer interface [polypeptide binding]; other site 1346614001142 inhibitor binding site; inhibition site 1346614001143 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1346614001144 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1346614001145 active site 1346614001146 substrate binding site [chemical binding]; other site 1346614001147 metal binding site [ion binding]; metal-binding site 1346614001148 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1346614001149 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1346614001150 hypothetical protein; Provisional; Region: PRK14641 1346614001151 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1346614001152 putative oligomer interface [polypeptide binding]; other site 1346614001153 putative RNA binding site [nucleotide binding]; other site 1346614001154 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1346614001155 NusA N-terminal domain; Region: NusA_N; pfam08529 1346614001156 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1346614001157 RNA binding site [nucleotide binding]; other site 1346614001158 homodimer interface [polypeptide binding]; other site 1346614001159 NusA-like KH domain; Region: KH_5; pfam13184 1346614001160 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1346614001161 G-X-X-G motif; other site 1346614001162 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1346614001163 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1346614001164 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1346614001165 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1346614001166 translation initiation factor IF-2; Region: IF-2; TIGR00487 1346614001167 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1346614001168 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1346614001169 G1 box; other site 1346614001170 putative GEF interaction site [polypeptide binding]; other site 1346614001171 GTP/Mg2+ binding site [chemical binding]; other site 1346614001172 Switch I region; other site 1346614001173 G2 box; other site 1346614001174 G3 box; other site 1346614001175 Switch II region; other site 1346614001176 G4 box; other site 1346614001177 G5 box; other site 1346614001178 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1346614001179 Translation-initiation factor 2; Region: IF-2; pfam11987 1346614001180 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1346614001181 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1346614001182 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1346614001183 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1346614001184 RNA binding site [nucleotide binding]; other site 1346614001185 active site 1346614001186 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1346614001187 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1346614001188 16S/18S rRNA binding site [nucleotide binding]; other site 1346614001189 S13e-L30e interaction site [polypeptide binding]; other site 1346614001190 25S rRNA binding site [nucleotide binding]; other site 1346614001191 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1346614001192 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1346614001193 RNase E interface [polypeptide binding]; other site 1346614001194 trimer interface [polypeptide binding]; other site 1346614001195 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1346614001196 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1346614001197 RNase E interface [polypeptide binding]; other site 1346614001198 trimer interface [polypeptide binding]; other site 1346614001199 active site 1346614001200 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1346614001201 putative nucleic acid binding region [nucleotide binding]; other site 1346614001202 G-X-X-G motif; other site 1346614001203 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1346614001204 RNA binding site [nucleotide binding]; other site 1346614001205 domain interface; other site 1346614001206 lipoprotein NlpI; Provisional; Region: PRK11189 1346614001207 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1346614001208 binding surface 1346614001209 TPR motif; other site 1346614001210 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1346614001211 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1346614001212 ATP binding site [chemical binding]; other site 1346614001213 Mg++ binding site [ion binding]; other site 1346614001214 motif III; other site 1346614001215 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1346614001216 nucleotide binding region [chemical binding]; other site 1346614001217 ATP-binding site [chemical binding]; other site 1346614001218 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1346614001219 putative RNA binding site [nucleotide binding]; other site 1346614001220 putative inner membrane protein; Provisional; Region: PRK11099 1346614001221 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 1346614001222 CPxP motif; other site 1346614001223 hypothetical protein; Provisional; Region: PRK10508 1346614001224 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1346614001225 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1346614001226 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1346614001227 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1346614001228 HlyD family secretion protein; Region: HlyD_3; pfam13437 1346614001229 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1346614001230 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1346614001231 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1346614001232 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1346614001233 Cupin-like domain; Region: Cupin_8; pfam13621 1346614001234 putative protease; Provisional; Region: PRK15447 1346614001235 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1346614001236 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1346614001237 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1346614001238 Peptidase family U32; Region: Peptidase_U32; pfam01136 1346614001239 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 1346614001240 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614001241 Coenzyme A binding pocket [chemical binding]; other site 1346614001242 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1346614001243 putative active site [active] 1346614001244 GIY-YIG motif/motif A; other site 1346614001245 putative metal binding site [ion binding]; other site 1346614001246 putrescine transporter; Provisional; Region: potE; PRK10655 1346614001247 ornithine decarboxylase; Provisional; Region: PRK13578 1346614001248 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1346614001249 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1346614001250 homodimer interface [polypeptide binding]; other site 1346614001251 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614001252 catalytic residue [active] 1346614001253 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1346614001254 hypothetical protein; Provisional; Region: PRK03467 1346614001255 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1346614001256 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1346614001257 NAD binding site [chemical binding]; other site 1346614001258 active site 1346614001259 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1346614001260 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 1346614001261 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1346614001262 trimer interface [polypeptide binding]; other site 1346614001263 active site 1346614001264 substrate binding site [chemical binding]; other site 1346614001265 CoA binding site [chemical binding]; other site 1346614001266 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1346614001267 AAA domain; Region: AAA_18; pfam13238 1346614001268 active site 1346614001269 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 1346614001270 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1346614001271 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 1346614001272 active site 1346614001273 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 1346614001274 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1346614001275 Walker A/P-loop; other site 1346614001276 ATP binding site [chemical binding]; other site 1346614001277 Q-loop/lid; other site 1346614001278 ABC transporter signature motif; other site 1346614001279 Walker B; other site 1346614001280 D-loop; other site 1346614001281 H-loop/switch region; other site 1346614001282 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 1346614001283 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1346614001284 Walker A/P-loop; other site 1346614001285 ATP binding site [chemical binding]; other site 1346614001286 Q-loop/lid; other site 1346614001287 ABC transporter signature motif; other site 1346614001288 Walker B; other site 1346614001289 D-loop; other site 1346614001290 H-loop/switch region; other site 1346614001291 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1346614001292 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 1346614001293 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 1346614001294 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 1346614001295 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 1346614001296 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 1346614001297 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1346614001298 DNA-binding site [nucleotide binding]; DNA binding site 1346614001299 UTRA domain; Region: UTRA; pfam07702 1346614001300 Predicted permease; Region: DUF318; cl17795 1346614001301 RelB antitoxin; Region: RelB; cl01171 1346614001302 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1346614001303 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; PRK11121 1346614001304 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 1346614001305 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1346614001306 ATP cone domain; Region: ATP-cone; pfam03477 1346614001307 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1346614001308 effector binding site; other site 1346614001309 active site 1346614001310 Zn binding site [ion binding]; other site 1346614001311 glycine loop; other site 1346614001312 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614001313 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614001314 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1346614001315 putative effector binding pocket; other site 1346614001316 dimerization interface [polypeptide binding]; other site 1346614001317 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1346614001318 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 1346614001319 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1346614001320 Ca binding site [ion binding]; other site 1346614001321 active site 1346614001322 catalytic site [active] 1346614001323 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1346614001324 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 1346614001325 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1346614001326 active site turn [active] 1346614001327 phosphorylation site [posttranslational modification] 1346614001328 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1346614001329 trehalose repressor; Provisional; Region: treR; PRK09492 1346614001330 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1346614001331 DNA binding site [nucleotide binding] 1346614001332 domain linker motif; other site 1346614001333 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 1346614001334 dimerization interface [polypeptide binding]; other site 1346614001335 ligand binding site [chemical binding]; other site 1346614001336 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 1346614001337 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1346614001338 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1346614001339 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1346614001340 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1346614001341 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1346614001342 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1346614001343 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 1346614001344 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1346614001345 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 1346614001346 active site 1346614001347 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 1346614001348 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 1346614001349 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 1346614001350 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1346614001351 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1346614001352 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1346614001353 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1346614001354 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1346614001355 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1346614001356 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1346614001357 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1346614001358 acyl-activating enzyme (AAE) consensus motif; other site 1346614001359 AMP binding site [chemical binding]; other site 1346614001360 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1346614001361 thioester reductase domain; Region: Thioester-redct; TIGR01746 1346614001362 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1346614001363 NAD(P) binding site [chemical binding]; other site 1346614001364 active site 1346614001365 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1346614001366 homotrimer interaction site [polypeptide binding]; other site 1346614001367 putative active site [active] 1346614001368 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 1346614001369 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 1346614001370 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 1346614001371 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 1346614001372 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1346614001373 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1346614001374 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1346614001375 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1346614001376 ABC-ATPase subunit interface; other site 1346614001377 dimer interface [polypeptide binding]; other site 1346614001378 putative PBP binding regions; other site 1346614001379 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1346614001380 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 1346614001381 putative ligand binding residues [chemical binding]; other site 1346614001382 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1346614001383 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1346614001384 Walker A/P-loop; other site 1346614001385 ATP binding site [chemical binding]; other site 1346614001386 Q-loop/lid; other site 1346614001387 ABC transporter signature motif; other site 1346614001388 Walker B; other site 1346614001389 D-loop; other site 1346614001390 H-loop/switch region; other site 1346614001391 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1346614001392 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 1346614001393 dimer interface [polypeptide binding]; other site 1346614001394 active site 1346614001395 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1346614001396 substrate binding site [chemical binding]; other site 1346614001397 catalytic residue [active] 1346614001398 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1346614001399 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1346614001400 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1346614001401 putative active site [active] 1346614001402 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1346614001403 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1346614001404 active site 1346614001405 putative substrate binding pocket [chemical binding]; other site 1346614001406 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1346614001407 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1346614001408 homotrimer interaction site [polypeptide binding]; other site 1346614001409 putative active site [active] 1346614001410 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1346614001411 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 1346614001412 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 1346614001413 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1346614001414 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1346614001415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 1346614001416 RNase E inhibitor protein; Provisional; Region: PRK11191 1346614001417 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 1346614001418 active site 1346614001419 dinuclear metal binding site [ion binding]; other site 1346614001420 dimerization interface [polypeptide binding]; other site 1346614001421 choline dehydrogenase; Validated; Region: PRK02106 1346614001422 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1346614001423 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1346614001424 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1346614001425 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614001426 Coenzyme A binding pocket [chemical binding]; other site 1346614001427 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1346614001428 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1346614001429 HIGH motif; other site 1346614001430 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1346614001431 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1346614001432 active site 1346614001433 KMSKS motif; other site 1346614001434 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1346614001435 tRNA binding surface [nucleotide binding]; other site 1346614001436 anticodon binding site; other site 1346614001437 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1346614001438 DNA polymerase III subunit chi; Validated; Region: PRK05728 1346614001439 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1346614001440 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1346614001441 interface (dimer of trimers) [polypeptide binding]; other site 1346614001442 Substrate-binding/catalytic site; other site 1346614001443 Zn-binding sites [ion binding]; other site 1346614001444 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 1346614001445 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1346614001446 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 1346614001447 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1346614001448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 1346614001449 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 1346614001450 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1346614001451 active site 1346614001452 metal binding site [ion binding]; metal-binding site 1346614001453 interdomain interaction site; other site 1346614001454 D5 N terminal like; Region: D5_N; smart00885 1346614001455 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 1346614001456 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 1346614001457 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1346614001458 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1346614001459 AAA domain; Region: AAA_23; pfam13476 1346614001460 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1346614001461 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614001462 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1346614001463 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1346614001464 active site clefts [active] 1346614001465 zinc binding site [ion binding]; other site 1346614001466 dimer interface [polypeptide binding]; other site 1346614001467 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1346614001468 active site 1346614001469 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 1346614001470 beta-galactosidase; Region: BGL; TIGR03356 1346614001471 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 1346614001472 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1346614001473 active site turn [active] 1346614001474 phosphorylation site [posttranslational modification] 1346614001475 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1346614001476 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1346614001477 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1346614001478 DNA binding site [nucleotide binding] 1346614001479 domain linker motif; other site 1346614001480 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1346614001481 dimerization interface (closed form) [polypeptide binding]; other site 1346614001482 ligand binding site [chemical binding]; other site 1346614001483 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 1346614001484 Fic/DOC family; Region: Fic; pfam02661 1346614001485 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 1346614001486 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1346614001487 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1346614001488 Uncharacterized small protein [Function unknown]; Region: COG2879 1346614001489 carbon starvation protein A; Provisional; Region: PRK15015 1346614001490 Carbon starvation protein CstA; Region: CstA; pfam02554 1346614001491 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1346614001492 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1346614001493 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1346614001494 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1346614001495 PQQ-like domain; Region: PQQ_2; pfam13360 1346614001496 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1346614001497 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1346614001498 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1346614001499 trimer interface [polypeptide binding]; other site 1346614001500 eyelet of channel; other site 1346614001501 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1346614001502 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1346614001503 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614001504 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614001505 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1346614001506 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614001507 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614001508 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1346614001509 L,D-transpeptidase; Provisional; Region: PRK10260 1346614001510 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 1346614001511 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1346614001512 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1346614001513 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1346614001514 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1346614001515 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1346614001516 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1346614001517 N-terminal plug; other site 1346614001518 ligand-binding site [chemical binding]; other site 1346614001519 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1346614001520 Putative catalytic domain, repeat 1, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_1; cd09106 1346614001521 PLD-like domain; Region: PLDc_2; pfam13091 1346614001522 putative active site [active] 1346614001523 putative catalytic site [active] 1346614001524 Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_2; cd09107 1346614001525 PLD-like domain; Region: PLDc_2; pfam13091 1346614001526 putative active site [active] 1346614001527 putative catalytic site [active] 1346614001528 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 1346614001529 homodimer interface [polypeptide binding]; other site 1346614001530 homotetramer interface [polypeptide binding]; other site 1346614001531 active site pocket [active] 1346614001532 cleavage site 1346614001533 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1346614001534 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1346614001535 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1346614001536 tetrameric interface [polypeptide binding]; other site 1346614001537 NAD binding site [chemical binding]; other site 1346614001538 catalytic residues [active] 1346614001539 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 1346614001540 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1346614001541 inhibitor-cofactor binding pocket; inhibition site 1346614001542 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614001543 catalytic residue [active] 1346614001544 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614001545 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614001546 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1346614001547 dimerization interface [polypeptide binding]; other site 1346614001548 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1346614001549 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1346614001550 active site 1346614001551 NAD binding site [chemical binding]; other site 1346614001552 metal binding site [ion binding]; metal-binding site 1346614001553 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1346614001554 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1346614001555 DNA binding residues [nucleotide binding] 1346614001556 dimerization interface [polypeptide binding]; other site 1346614001557 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1346614001558 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1346614001559 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 1346614001560 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1346614001561 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1346614001562 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1346614001563 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 1346614001564 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1346614001565 active site 1346614001566 Zn binding site [ion binding]; other site 1346614001567 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1346614001568 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1346614001569 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1346614001570 DNA binding residues [nucleotide binding] 1346614001571 dimerization interface [polypeptide binding]; other site 1346614001572 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1346614001573 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 1346614001574 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1346614001575 classical (c) SDRs; Region: SDR_c; cd05233 1346614001576 NAD(P) binding site [chemical binding]; other site 1346614001577 active site 1346614001578 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 1346614001579 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1346614001580 classical (c) SDRs; Region: SDR_c; cd05233 1346614001581 NAD(P) binding site [chemical binding]; other site 1346614001582 active site 1346614001583 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 1346614001584 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1346614001585 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1346614001586 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 1346614001587 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1346614001588 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 1346614001589 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1346614001590 NAD binding site [chemical binding]; other site 1346614001591 catalytic residues [active] 1346614001592 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 1346614001593 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 1346614001594 tetramer interface [polypeptide binding]; other site 1346614001595 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 1346614001596 tetramer interface [polypeptide binding]; other site 1346614001597 active site 1346614001598 metal binding site [ion binding]; metal-binding site 1346614001599 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 1346614001600 putative substrate binding pocket [chemical binding]; other site 1346614001601 trimer interface [polypeptide binding]; other site 1346614001602 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 1346614001603 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1346614001604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614001605 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1346614001606 putative substrate translocation pore; other site 1346614001607 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 1346614001608 Cupin domain; Region: Cupin_2; cl17218 1346614001609 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614001610 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 1346614001611 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1346614001612 Flavin Reductases; Region: FlaRed; cl00801 1346614001613 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 1346614001614 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1346614001615 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1346614001616 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1346614001617 DNA-binding site [nucleotide binding]; DNA binding site 1346614001618 FCD domain; Region: FCD; pfam07729 1346614001619 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1346614001620 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 1346614001621 NAD binding site [chemical binding]; other site 1346614001622 homotetramer interface [polypeptide binding]; other site 1346614001623 homodimer interface [polypeptide binding]; other site 1346614001624 active site 1346614001625 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1346614001626 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1346614001627 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1346614001628 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 1346614001629 putative active site pocket [active] 1346614001630 metal binding site [ion binding]; metal-binding site 1346614001631 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1346614001632 Amidohydrolase; Region: Amidohydro_2; pfam04909 1346614001633 short chain dehydrogenase; Provisional; Region: PRK08628 1346614001634 classical (c) SDRs; Region: SDR_c; cd05233 1346614001635 NAD(P) binding site [chemical binding]; other site 1346614001636 active site 1346614001637 Domain of unknown function (DUF718); Region: DUF718; pfam05336 1346614001638 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1346614001639 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614001640 putative substrate translocation pore; other site 1346614001641 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1346614001642 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1346614001643 metal binding site [ion binding]; metal-binding site 1346614001644 active site 1346614001645 I-site; other site 1346614001646 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 1346614001647 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614001648 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614001649 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1346614001650 putative effector binding pocket; other site 1346614001651 putative dimerization interface [polypeptide binding]; other site 1346614001652 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1346614001653 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1346614001654 active site 1346614001655 catalytic tetrad [active] 1346614001656 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 1346614001657 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 1346614001658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614001659 S-adenosylmethionine binding site [chemical binding]; other site 1346614001660 DNA polymerase III subunit psi; Validated; Region: PRK06856 1346614001661 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 1346614001662 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614001663 Coenzyme A binding pocket [chemical binding]; other site 1346614001664 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1346614001665 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1346614001666 G1 box; other site 1346614001667 putative GEF interaction site [polypeptide binding]; other site 1346614001668 GTP/Mg2+ binding site [chemical binding]; other site 1346614001669 Switch I region; other site 1346614001670 G2 box; other site 1346614001671 G3 box; other site 1346614001672 Switch II region; other site 1346614001673 G4 box; other site 1346614001674 G5 box; other site 1346614001675 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1346614001676 periplasmic protein; Provisional; Region: PRK10568 1346614001677 BON domain; Region: BON; pfam04972 1346614001678 BON domain; Region: BON; pfam04972 1346614001679 CsbD-like; Region: CsbD; cl17424 1346614001680 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1346614001681 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1346614001682 active site 1346614001683 nucleophile elbow; other site 1346614001684 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1346614001685 active site 1346614001686 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1346614001687 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1346614001688 Nucleoside recognition; Region: Gate; pfam07670 1346614001689 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1346614001690 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1346614001691 intersubunit interface [polypeptide binding]; other site 1346614001692 active site 1346614001693 catalytic residue [active] 1346614001694 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1346614001695 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1346614001696 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1346614001697 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1346614001698 phosphopentomutase; Provisional; Region: PRK05362 1346614001699 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1346614001700 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1346614001701 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1346614001702 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1346614001703 putative DNA binding site [nucleotide binding]; other site 1346614001704 putative Zn2+ binding site [ion binding]; other site 1346614001705 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 1346614001706 hypothetical protein; Provisional; Region: PRK11246 1346614001707 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 1346614001708 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1346614001709 motif I; other site 1346614001710 motif II; other site 1346614001711 DNA repair protein RadA; Region: sms; TIGR00416 1346614001712 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1346614001713 Walker A motif/ATP binding site; other site 1346614001714 ATP binding site [chemical binding]; other site 1346614001715 Walker B motif; other site 1346614001716 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1346614001717 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1346614001718 non-specific DNA binding site [nucleotide binding]; other site 1346614001719 salt bridge; other site 1346614001720 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 1346614001721 sequence-specific DNA binding site [nucleotide binding]; other site 1346614001722 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 1346614001723 active site 1346614001724 (T/H)XGH motif; other site 1346614001725 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1346614001726 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1346614001727 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1346614001728 putative NAD(P) binding site [chemical binding]; other site 1346614001729 dimer interface [polypeptide binding]; other site 1346614001730 LysR family transcriptional regulator; Provisional; Region: PRK14997 1346614001731 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614001732 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1346614001733 putative effector binding pocket; other site 1346614001734 dimerization interface [polypeptide binding]; other site 1346614001735 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1346614001736 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1346614001737 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1346614001738 ABC transporter; Region: ABC_tran_2; pfam12848 1346614001739 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1346614001740 putative outer membrane lipoprotein; Provisional; Region: PRK09967 1346614001741 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1346614001742 ligand binding site [chemical binding]; other site 1346614001743 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 1346614001744 HAMP domain; Region: HAMP; pfam00672 1346614001745 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1346614001746 metal binding site [ion binding]; metal-binding site 1346614001747 active site 1346614001748 I-site; other site 1346614001749 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 1346614001750 lytic murein transglycosylase; Provisional; Region: PRK11619 1346614001751 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1346614001752 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1346614001753 catalytic residue [active] 1346614001754 Trp operon repressor; Provisional; Region: PRK01381 1346614001755 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 1346614001756 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1346614001757 catalytic core [active] 1346614001758 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1346614001759 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614001760 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1346614001761 hypothetical protein; Provisional; Region: PRK10756 1346614001762 CreA protein; Region: CreA; pfam05981 1346614001763 two-component response regulator; Provisional; Region: PRK11173 1346614001764 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614001765 active site 1346614001766 phosphorylation site [posttranslational modification] 1346614001767 intermolecular recognition site; other site 1346614001768 dimerization interface [polypeptide binding]; other site 1346614001769 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1346614001770 DNA binding site [nucleotide binding] 1346614001771 putative RNA methyltransferase; Provisional; Region: PRK10433 1346614001772 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 1346614001773 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 1346614001774 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1346614001775 putative catalytic residues [active] 1346614001776 putative nucleotide binding site [chemical binding]; other site 1346614001777 putative aspartate binding site [chemical binding]; other site 1346614001778 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 1346614001779 dimer interface [polypeptide binding]; other site 1346614001780 putative threonine allosteric regulatory site; other site 1346614001781 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 1346614001782 putative threonine allosteric regulatory site; other site 1346614001783 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1346614001784 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1346614001785 homoserine kinase; Provisional; Region: PRK01212 1346614001786 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1346614001787 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1346614001788 threonine synthase; Validated; Region: PRK09225 1346614001789 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1346614001790 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1346614001791 catalytic residue [active] 1346614001792 hypothetical protein; Validated; Region: PRK02101 1346614001793 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1346614001794 amino acid carrier protein; Region: agcS; TIGR00835 1346614001795 transaldolase-like protein; Provisional; Region: PTZ00411 1346614001796 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1346614001797 active site 1346614001798 dimer interface [polypeptide binding]; other site 1346614001799 catalytic residue [active] 1346614001800 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1346614001801 MPT binding site; other site 1346614001802 trimer interface [polypeptide binding]; other site 1346614001803 metabolite-proton symporter; Region: 2A0106; TIGR00883 1346614001804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614001805 putative substrate translocation pore; other site 1346614001806 hypothetical protein; Provisional; Region: PRK10659 1346614001807 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1346614001808 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1346614001809 nucleotide binding site [chemical binding]; other site 1346614001810 chaperone protein DnaJ; Provisional; Region: PRK10767 1346614001811 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1346614001812 HSP70 interaction site [polypeptide binding]; other site 1346614001813 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1346614001814 substrate binding site [polypeptide binding]; other site 1346614001815 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1346614001816 Zn binding sites [ion binding]; other site 1346614001817 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1346614001818 dimer interface [polypeptide binding]; other site 1346614001819 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 1346614001820 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 1346614001821 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614001822 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 1346614001823 putative dimerization interface [polypeptide binding]; other site 1346614001824 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1346614001825 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1346614001826 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1346614001827 active site 1346614001828 Riboflavin kinase; Region: Flavokinase; smart00904 1346614001829 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1346614001830 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1346614001831 active site 1346614001832 HIGH motif; other site 1346614001833 nucleotide binding site [chemical binding]; other site 1346614001834 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1346614001835 active site 1346614001836 KMSKS motif; other site 1346614001837 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1346614001838 tRNA binding surface [nucleotide binding]; other site 1346614001839 anticodon binding site; other site 1346614001840 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1346614001841 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1346614001842 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1346614001843 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1346614001844 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1346614001845 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1346614001846 transcriptional regulator; Provisional; Region: PRK10632 1346614001847 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614001848 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1346614001849 putative effector binding pocket; other site 1346614001850 dimerization interface [polypeptide binding]; other site 1346614001851 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 1346614001852 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1346614001853 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1346614001854 substrate binding pocket [chemical binding]; other site 1346614001855 active site 1346614001856 iron coordination sites [ion binding]; other site 1346614001857 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1346614001858 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1346614001859 active site 1346614001860 TDP-binding site; other site 1346614001861 acceptor substrate-binding pocket; other site 1346614001862 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1346614001863 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1346614001864 inhibitor site; inhibition site 1346614001865 active site 1346614001866 dimer interface [polypeptide binding]; other site 1346614001867 catalytic residue [active] 1346614001868 Dehydratase family; Region: ILVD_EDD; pfam00920 1346614001869 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1346614001870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614001871 putative substrate translocation pore; other site 1346614001872 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1346614001873 active site 1346614001874 intersubunit interface [polypeptide binding]; other site 1346614001875 catalytic residue [active] 1346614001876 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 1346614001877 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1346614001878 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1346614001879 DNA-binding site [nucleotide binding]; DNA binding site 1346614001880 FCD domain; Region: FCD; pfam07729 1346614001881 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1346614001882 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1346614001883 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1346614001884 carbamoyl-phosphate synthase, small subunit; Region: CPSaseIIsmall; TIGR01368 1346614001885 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1346614001886 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1346614001887 catalytic site [active] 1346614001888 subunit interface [polypeptide binding]; other site 1346614001889 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1346614001890 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1346614001891 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1346614001892 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1346614001893 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1346614001894 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1346614001895 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1346614001896 IMP binding site; other site 1346614001897 dimer interface [polypeptide binding]; other site 1346614001898 interdomain contacts; other site 1346614001899 partial ornithine binding site; other site 1346614001900 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 1346614001901 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1346614001902 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 1346614001903 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1346614001904 TrkA-N domain; Region: TrkA_N; pfam02254 1346614001905 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1346614001906 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1346614001907 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1346614001908 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1346614001909 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1346614001910 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1346614001911 folate binding site [chemical binding]; other site 1346614001912 NADP+ binding site [chemical binding]; other site 1346614001913 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 1346614001914 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 1346614001915 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1346614001916 active site 1346614001917 metal binding site [ion binding]; metal-binding site 1346614001918 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1346614001919 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1346614001920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614001921 S-adenosylmethionine binding site [chemical binding]; other site 1346614001922 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1346614001923 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1346614001924 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1346614001925 SurA N-terminal domain; Region: SurA_N; pfam09312 1346614001926 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1346614001927 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1346614001928 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 1346614001929 OstA-like protein; Region: OstA; pfam03968 1346614001930 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1346614001931 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 1346614001932 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1346614001933 putative metal binding site [ion binding]; other site 1346614001934 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1346614001935 HSP70 interaction site [polypeptide binding]; other site 1346614001936 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1346614001937 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1346614001938 active site 1346614001939 ATP-dependent helicase HepA; Validated; Region: PRK04914 1346614001940 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1346614001941 ATP binding site [chemical binding]; other site 1346614001942 putative Mg++ binding site [ion binding]; other site 1346614001943 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1346614001944 nucleotide binding region [chemical binding]; other site 1346614001945 ATP-binding site [chemical binding]; other site 1346614001946 DNA polymerase II; Reviewed; Region: PRK05762 1346614001947 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 1346614001948 active site 1346614001949 catalytic site [active] 1346614001950 substrate binding site [chemical binding]; other site 1346614001951 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 1346614001952 active site 1346614001953 metal-binding site 1346614001954 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1346614001955 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1346614001956 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 1346614001957 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1346614001958 putative valine binding site [chemical binding]; other site 1346614001959 dimer interface [polypeptide binding]; other site 1346614001960 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 1346614001961 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1346614001962 PYR/PP interface [polypeptide binding]; other site 1346614001963 dimer interface [polypeptide binding]; other site 1346614001964 TPP binding site [chemical binding]; other site 1346614001965 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1346614001966 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1346614001967 TPP-binding site [chemical binding]; other site 1346614001968 dimer interface [polypeptide binding]; other site 1346614001969 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 1346614001970 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 1346614001971 Walker A/P-loop; other site 1346614001972 ATP binding site [chemical binding]; other site 1346614001973 Q-loop/lid; other site 1346614001974 ABC transporter signature motif; other site 1346614001975 Walker B; other site 1346614001976 D-loop; other site 1346614001977 H-loop/switch region; other site 1346614001978 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 1346614001979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614001980 dimer interface [polypeptide binding]; other site 1346614001981 conserved gate region; other site 1346614001982 putative PBP binding loops; other site 1346614001983 ABC-ATPase subunit interface; other site 1346614001984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614001985 dimer interface [polypeptide binding]; other site 1346614001986 conserved gate region; other site 1346614001987 putative PBP binding loops; other site 1346614001988 ABC-ATPase subunit interface; other site 1346614001989 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 1346614001990 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1346614001991 transcriptional regulator SgrR; Provisional; Region: PRK13626 1346614001992 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1346614001993 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1346614001994 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614001995 sugar efflux transporter; Region: 2A0120; TIGR00899 1346614001996 putative substrate translocation pore; other site 1346614001997 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 1346614001998 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1346614001999 transmembrane helices; other site 1346614002000 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1346614002001 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1346614002002 substrate binding site [chemical binding]; other site 1346614002003 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1346614002004 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1346614002005 substrate binding site [chemical binding]; other site 1346614002006 ligand binding site [chemical binding]; other site 1346614002007 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1346614002008 tartrate dehydrogenase; Region: TTC; TIGR02089 1346614002009 2-isopropylmalate synthase; Validated; Region: PRK00915 1346614002010 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1346614002011 active site 1346614002012 catalytic residues [active] 1346614002013 metal binding site [ion binding]; metal-binding site 1346614002014 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1346614002015 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1346614002016 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614002017 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 1346614002018 putative substrate binding pocket [chemical binding]; other site 1346614002019 putative dimerization interface [polypeptide binding]; other site 1346614002020 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1346614002021 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1346614002022 acyl-activating enzyme (AAE) consensus motif; other site 1346614002023 putative AMP binding site [chemical binding]; other site 1346614002024 putative active site [active] 1346614002025 putative CoA binding site [chemical binding]; other site 1346614002026 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 1346614002027 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1346614002028 PYR/PP interface [polypeptide binding]; other site 1346614002029 dimer interface [polypeptide binding]; other site 1346614002030 TPP binding site [chemical binding]; other site 1346614002031 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1346614002032 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1346614002033 TPP-binding site [chemical binding]; other site 1346614002034 dimer interface [polypeptide binding]; other site 1346614002035 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1346614002036 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1346614002037 putative valine binding site [chemical binding]; other site 1346614002038 dimer interface [polypeptide binding]; other site 1346614002039 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1346614002040 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 1346614002041 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1346614002042 DNA binding site [nucleotide binding] 1346614002043 domain linker motif; other site 1346614002044 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1346614002045 dimerization interface [polypeptide binding]; other site 1346614002046 ligand binding site [chemical binding]; other site 1346614002047 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 1346614002048 cell division protein MraZ; Reviewed; Region: PRK00326 1346614002049 MraZ protein; Region: MraZ; pfam02381 1346614002050 MraZ protein; Region: MraZ; pfam02381 1346614002051 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 1346614002052 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1346614002053 cell division protein FtsL; Provisional; Region: PRK10772 1346614002054 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1346614002055 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1346614002056 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1346614002057 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1346614002058 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1346614002059 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1346614002060 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1346614002061 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 1346614002062 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1346614002063 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1346614002064 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1346614002065 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1346614002066 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1346614002067 Mg++ binding site [ion binding]; other site 1346614002068 putative catalytic motif [active] 1346614002069 putative substrate binding site [chemical binding]; other site 1346614002070 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 1346614002071 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1346614002072 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1346614002073 cell division protein FtsW; Provisional; Region: PRK10774 1346614002074 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1346614002075 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1346614002076 active site 1346614002077 homodimer interface [polypeptide binding]; other site 1346614002078 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1346614002079 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1346614002080 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1346614002081 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1346614002082 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1346614002083 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1346614002084 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1346614002085 cell division protein FtsQ; Provisional; Region: PRK10775 1346614002086 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1346614002087 Cell division protein FtsQ; Region: FtsQ; pfam03799 1346614002088 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 1346614002089 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1346614002090 Cell division protein FtsA; Region: FtsA; pfam14450 1346614002091 cell division protein FtsZ; Validated; Region: PRK09330 1346614002092 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1346614002093 nucleotide binding site [chemical binding]; other site 1346614002094 SulA interaction site; other site 1346614002095 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1346614002096 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1346614002097 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4701 1346614002098 Secretion monitor precursor protein (SecM); Region: SecM; pfam06558 1346614002099 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1346614002100 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1346614002101 SEC-C motif; Region: SEC-C; pfam02810 1346614002102 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1346614002103 active site 1346614002104 8-oxo-dGMP binding site [chemical binding]; other site 1346614002105 nudix motif; other site 1346614002106 metal binding site [ion binding]; metal-binding site 1346614002107 DNA gyrase inhibitor; Reviewed; Region: PRK00418 1346614002108 hypothetical protein; Provisional; Region: PRK05287 1346614002109 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1346614002110 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1346614002111 CoA-binding site [chemical binding]; other site 1346614002112 ATP-binding [chemical binding]; other site 1346614002113 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 1346614002114 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1346614002115 active site 1346614002116 type IV pilin biogenesis protein; Provisional; Region: PRK10573 1346614002117 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1346614002118 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1346614002119 hypothetical protein; Provisional; Region: PRK10436 1346614002120 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1346614002121 Walker A motif; other site 1346614002122 ATP binding site [chemical binding]; other site 1346614002123 Walker B motif; other site 1346614002124 putative major pilin subunit; Provisional; Region: PRK10574 1346614002125 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1346614002126 Pilin (bacterial filament); Region: Pilin; pfam00114 1346614002127 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 1346614002128 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1346614002129 dimerization interface [polypeptide binding]; other site 1346614002130 active site 1346614002131 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1346614002132 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1346614002133 amidase catalytic site [active] 1346614002134 Zn binding residues [ion binding]; other site 1346614002135 substrate binding site [chemical binding]; other site 1346614002136 regulatory protein AmpE; Provisional; Region: PRK10987 1346614002137 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1346614002138 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1346614002139 inhibitor-cofactor binding pocket; inhibition site 1346614002140 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614002141 catalytic residue [active] 1346614002142 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1346614002143 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1346614002144 Cl- selectivity filter; other site 1346614002145 Cl- binding residues [ion binding]; other site 1346614002146 pore gating glutamate residue; other site 1346614002147 dimer interface [polypeptide binding]; other site 1346614002148 H+/Cl- coupling transport residue; other site 1346614002149 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1346614002150 hypothetical protein; Provisional; Region: PRK10578 1346614002151 UPF0126 domain; Region: UPF0126; pfam03458 1346614002152 UPF0126 domain; Region: UPF0126; pfam03458 1346614002153 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 1346614002154 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1346614002155 cobalamin binding residues [chemical binding]; other site 1346614002156 putative BtuC binding residues; other site 1346614002157 dimer interface [polypeptide binding]; other site 1346614002158 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1346614002159 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1346614002160 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 1346614002161 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1346614002162 Zn2+ binding site [ion binding]; other site 1346614002163 Mg2+ binding site [ion binding]; other site 1346614002164 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1346614002165 serine endoprotease; Provisional; Region: PRK10942 1346614002166 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1346614002167 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1346614002168 protein binding site [polypeptide binding]; other site 1346614002169 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1346614002170 protein binding site [polypeptide binding]; other site 1346614002171 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 1346614002172 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 1346614002173 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1346614002174 dimerization interface [polypeptide binding]; other site 1346614002175 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1346614002176 dimer interface [polypeptide binding]; other site 1346614002177 phosphorylation site [posttranslational modification] 1346614002178 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614002179 ATP binding site [chemical binding]; other site 1346614002180 Mg2+ binding site [ion binding]; other site 1346614002181 G-X-G motif; other site 1346614002182 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 1346614002183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614002184 active site 1346614002185 phosphorylation site [posttranslational modification] 1346614002186 intermolecular recognition site; other site 1346614002187 dimerization interface [polypeptide binding]; other site 1346614002188 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1346614002189 putative binding surface; other site 1346614002190 active site 1346614002191 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1346614002192 TRAM domain; Region: TRAM; pfam01938 1346614002193 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1346614002194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614002195 S-adenosylmethionine binding site [chemical binding]; other site 1346614002196 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 1346614002197 HD domain; Region: HD_4; pfam13328 1346614002198 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1346614002199 synthetase active site [active] 1346614002200 NTP binding site [chemical binding]; other site 1346614002201 metal binding site [ion binding]; metal-binding site 1346614002202 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1346614002203 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1346614002204 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1346614002205 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1346614002206 homodimer interface [polypeptide binding]; other site 1346614002207 metal binding site [ion binding]; metal-binding site 1346614002208 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1346614002209 homodimer interface [polypeptide binding]; other site 1346614002210 active site 1346614002211 putative chemical substrate binding site [chemical binding]; other site 1346614002212 metal binding site [ion binding]; metal-binding site 1346614002213 CTP synthetase; Validated; Region: pyrG; PRK05380 1346614002214 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1346614002215 Catalytic site [active] 1346614002216 active site 1346614002217 UTP binding site [chemical binding]; other site 1346614002218 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1346614002219 active site 1346614002220 putative oxyanion hole; other site 1346614002221 catalytic triad [active] 1346614002222 enolase; Provisional; Region: eno; PRK00077 1346614002223 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1346614002224 dimer interface [polypeptide binding]; other site 1346614002225 metal binding site [ion binding]; metal-binding site 1346614002226 substrate binding pocket [chemical binding]; other site 1346614002227 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1346614002228 methionine gamma-lyase; Provisional; Region: PRK07503 1346614002229 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1346614002230 homodimer interface [polypeptide binding]; other site 1346614002231 substrate-cofactor binding pocket; other site 1346614002232 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614002233 catalytic residue [active] 1346614002234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1346614002235 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1346614002236 tetramer interface [polypeptide binding]; other site 1346614002237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614002238 ABC-ATPase subunit interface; other site 1346614002239 putative proline-specific permease; Provisional; Region: proY; PRK10580 1346614002240 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1346614002241 active sites [active] 1346614002242 tetramer interface [polypeptide binding]; other site 1346614002243 urocanate hydratase; Provisional; Region: PRK05414 1346614002244 benzoate transport; Region: 2A0115; TIGR00895 1346614002245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614002246 putative substrate translocation pore; other site 1346614002247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614002248 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1346614002249 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1346614002250 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1346614002251 active site 1346614002252 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 1346614002253 Flavodoxin; Region: Flavodoxin_1; pfam00258 1346614002254 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1346614002255 FAD binding pocket [chemical binding]; other site 1346614002256 FAD binding motif [chemical binding]; other site 1346614002257 catalytic residues [active] 1346614002258 NAD binding pocket [chemical binding]; other site 1346614002259 phosphate binding motif [ion binding]; other site 1346614002260 beta-alpha-beta structure motif; other site 1346614002261 sulfite reductase subunit beta; Provisional; Region: PRK13504 1346614002262 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1346614002263 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1346614002264 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1346614002265 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1346614002266 Active Sites [active] 1346614002267 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 1346614002268 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1346614002269 metal binding site [ion binding]; metal-binding site 1346614002270 siroheme synthase; Provisional; Region: cysG; PRK10637 1346614002271 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1346614002272 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1346614002273 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1346614002274 active site 1346614002275 SAM binding site [chemical binding]; other site 1346614002276 homodimer interface [polypeptide binding]; other site 1346614002277 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1346614002278 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1346614002279 Active Sites [active] 1346614002280 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 1346614002281 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1346614002282 CysD dimerization site [polypeptide binding]; other site 1346614002283 G1 box; other site 1346614002284 putative GEF interaction site [polypeptide binding]; other site 1346614002285 GTP/Mg2+ binding site [chemical binding]; other site 1346614002286 Switch I region; other site 1346614002287 G2 box; other site 1346614002288 G3 box; other site 1346614002289 Switch II region; other site 1346614002290 G4 box; other site 1346614002291 G5 box; other site 1346614002292 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1346614002293 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1346614002294 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1346614002295 ligand-binding site [chemical binding]; other site 1346614002296 hypothetical protein; Provisional; Region: PRK10726 1346614002297 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1346614002298 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1346614002299 Walker A/P-loop; other site 1346614002300 ATP binding site [chemical binding]; other site 1346614002301 Q-loop/lid; other site 1346614002302 ABC transporter signature motif; other site 1346614002303 Walker B; other site 1346614002304 D-loop; other site 1346614002305 H-loop/switch region; other site 1346614002306 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1346614002307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614002308 dimer interface [polypeptide binding]; other site 1346614002309 conserved gate region; other site 1346614002310 putative PBP binding loops; other site 1346614002311 ABC-ATPase subunit interface; other site 1346614002312 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1346614002313 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1346614002314 substrate binding pocket [chemical binding]; other site 1346614002315 membrane-bound complex binding site; other site 1346614002316 hinge residues; other site 1346614002317 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 1346614002318 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1346614002319 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1346614002320 substrate binding site; other site 1346614002321 dimer interface; other site 1346614002322 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1346614002323 homotrimer interaction site [polypeptide binding]; other site 1346614002324 zinc binding site [ion binding]; other site 1346614002325 CDP-binding sites; other site 1346614002326 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 1346614002327 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1346614002328 Permutation of conserved domain; other site 1346614002329 active site 1346614002330 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1346614002331 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1346614002332 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614002333 S-adenosylmethionine binding site [chemical binding]; other site 1346614002334 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1346614002335 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1346614002336 Peptidase family M23; Region: Peptidase_M23; pfam01551 1346614002337 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 1346614002338 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1346614002339 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1346614002340 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1346614002341 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1346614002342 DNA binding residues [nucleotide binding] 1346614002343 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1346614002344 MutS domain I; Region: MutS_I; pfam01624 1346614002345 MutS domain II; Region: MutS_II; pfam05188 1346614002346 MutS domain III; Region: MutS_III; pfam05192 1346614002347 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1346614002348 Walker A/P-loop; other site 1346614002349 ATP binding site [chemical binding]; other site 1346614002350 Q-loop/lid; other site 1346614002351 ABC transporter signature motif; other site 1346614002352 Walker B; other site 1346614002353 D-loop; other site 1346614002354 H-loop/switch region; other site 1346614002355 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1346614002356 active site 1346614002357 P-loop; other site 1346614002358 phosphorylation site [posttranslational modification] 1346614002359 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 1346614002360 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1346614002361 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1346614002362 beta-galactosidase; Region: BGL; TIGR03356 1346614002363 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 1346614002364 Cupin domain; Region: Cupin_2; pfam07883 1346614002365 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614002366 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 1346614002367 putative active site [active] 1346614002368 YdjC motif; other site 1346614002369 Mg binding site [ion binding]; other site 1346614002370 putative homodimer interface [polypeptide binding]; other site 1346614002371 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614002372 putative substrate translocation pore; other site 1346614002373 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1346614002374 hypothetical protein; Validated; Region: PRK03661 1346614002375 recombinase A; Provisional; Region: recA; PRK09354 1346614002376 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1346614002377 hexamer interface [polypeptide binding]; other site 1346614002378 Walker A motif; other site 1346614002379 ATP binding site [chemical binding]; other site 1346614002380 Walker B motif; other site 1346614002381 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1346614002382 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1346614002383 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1346614002384 motif 1; other site 1346614002385 active site 1346614002386 motif 2; other site 1346614002387 motif 3; other site 1346614002388 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1346614002389 DHHA1 domain; Region: DHHA1; pfam02272 1346614002390 carbon storage regulator; Provisional; Region: PRK01712 1346614002391 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 1346614002392 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1346614002393 motif II; other site 1346614002394 Predicted membrane protein [Function unknown]; Region: COG1238 1346614002395 glutamate--cysteine ligase; Provisional; Region: PRK02107 1346614002396 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1346614002397 hypothetical protein; Provisional; Region: PRK11573 1346614002398 Domain of unknown function DUF21; Region: DUF21; pfam01595 1346614002399 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1346614002400 Transporter associated domain; Region: CorC_HlyC; smart01091 1346614002401 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 1346614002402 signal recognition particle protein; Provisional; Region: PRK10867 1346614002403 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1346614002404 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1346614002405 P loop; other site 1346614002406 GTP binding site [chemical binding]; other site 1346614002407 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1346614002408 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1346614002409 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1346614002410 RimM N-terminal domain; Region: RimM; pfam01782 1346614002411 PRC-barrel domain; Region: PRC; pfam05239 1346614002412 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1346614002413 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1346614002414 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 1346614002415 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1346614002416 Protein of unknown function, DUF481; Region: DUF481; cl01213 1346614002417 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1346614002418 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1346614002419 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 1346614002420 Chorismate mutase type II; Region: CM_2; cl00693 1346614002421 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1346614002422 prephenate dehydrogenase; Validated; Region: PRK08507 1346614002423 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 1346614002424 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 1346614002425 Prephenate dehydratase; Region: PDT; pfam00800 1346614002426 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1346614002427 putative L-Phe binding site [chemical binding]; other site 1346614002428 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1346614002429 30S subunit binding site; other site 1346614002430 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 1346614002431 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1346614002432 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1346614002433 RNA binding surface [nucleotide binding]; other site 1346614002434 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1346614002435 active site 1346614002436 hypothetical protein; Provisional; Region: PRK10723 1346614002437 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1346614002438 protein disaggregation chaperone; Provisional; Region: PRK10865 1346614002439 Clp amino terminal domain; Region: Clp_N; pfam02861 1346614002440 Clp amino terminal domain; Region: Clp_N; pfam02861 1346614002441 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1346614002442 Walker A motif; other site 1346614002443 ATP binding site [chemical binding]; other site 1346614002444 Walker B motif; other site 1346614002445 arginine finger; other site 1346614002446 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1346614002447 Walker A motif; other site 1346614002448 ATP binding site [chemical binding]; other site 1346614002449 Walker B motif; other site 1346614002450 arginine finger; other site 1346614002451 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1346614002452 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 1346614002453 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1346614002454 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1346614002455 putative acyl-acceptor binding pocket; other site 1346614002456 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1346614002457 acyl carrier protein; Provisional; Region: PRK05350 1346614002458 Predicted membrane protein [Function unknown]; Region: COG4648 1346614002459 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1346614002460 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1346614002461 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1346614002462 acyl-activating enzyme (AAE) consensus motif; other site 1346614002463 acyl-activating enzyme (AAE) consensus motif; other site 1346614002464 AMP binding site [chemical binding]; other site 1346614002465 active site 1346614002466 CoA binding site [chemical binding]; other site 1346614002467 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 1346614002468 active site 2 [active] 1346614002469 dimer interface [polypeptide binding]; other site 1346614002470 active site 1 [active] 1346614002471 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1346614002472 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1346614002473 Putative Catalytic site; other site 1346614002474 DXD motif; other site 1346614002475 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1346614002476 putative acyl-acceptor binding pocket; other site 1346614002477 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1346614002478 active site 1346614002479 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1346614002480 Predicted exporter [General function prediction only]; Region: COG4258 1346614002481 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 1346614002482 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 1346614002483 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1346614002484 dimer interface [polypeptide binding]; other site 1346614002485 active site 1346614002486 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1346614002487 active site 2 [active] 1346614002488 active site 1 [active] 1346614002489 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1346614002490 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 1346614002491 NAD(P) binding site [chemical binding]; other site 1346614002492 active site 1346614002493 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 1346614002494 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1346614002495 dimer interface [polypeptide binding]; other site 1346614002496 active site 1346614002497 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1346614002498 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1346614002499 active site 1346614002500 catalytic tetrad [active] 1346614002501 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614002502 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614002503 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1346614002504 dimerization interface [polypeptide binding]; other site 1346614002505 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1346614002506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614002507 putative substrate translocation pore; other site 1346614002508 hypothetical protein; Provisional; Region: PRK05421 1346614002509 putative catalytic site [active] 1346614002510 putative phosphate binding site [ion binding]; other site 1346614002511 putative metal binding site [ion binding]; other site 1346614002512 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1346614002513 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1346614002514 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1346614002515 catalytic residue [active] 1346614002516 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1346614002517 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1346614002518 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1346614002519 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 1346614002520 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614002521 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1346614002522 RNA/DNA hybrid binding site [nucleotide binding]; other site 1346614002523 active site 1346614002524 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1346614002525 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1346614002526 active site 1346614002527 catalytic site [active] 1346614002528 substrate binding site [chemical binding]; other site 1346614002529 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 1346614002530 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1346614002531 Na binding site [ion binding]; other site 1346614002532 putative substrate binding site [chemical binding]; other site 1346614002533 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1346614002534 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1346614002535 DNA-binding site [nucleotide binding]; DNA binding site 1346614002536 FCD domain; Region: FCD; pfam07729 1346614002537 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 1346614002538 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1346614002539 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 1346614002540 active site 1346614002541 catalytic site [active] 1346614002542 tetramer interface [polypeptide binding]; other site 1346614002543 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1346614002544 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1346614002545 N-terminal plug; other site 1346614002546 ligand-binding site [chemical binding]; other site 1346614002547 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 1346614002548 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1346614002549 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1346614002550 IucA / IucC family; Region: IucA_IucC; pfam04183 1346614002551 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1346614002552 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1346614002553 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1346614002554 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1346614002555 IucA / IucC family; Region: IucA_IucC; pfam04183 1346614002556 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1346614002557 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1346614002558 FAD binding pocket [chemical binding]; other site 1346614002559 FAD binding motif [chemical binding]; other site 1346614002560 phosphate binding motif [ion binding]; other site 1346614002561 NAD binding pocket [chemical binding]; other site 1346614002562 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1346614002563 Predicted transcriptional regulator [Transcription]; Region: COG3905 1346614002564 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 1346614002565 amidase; Provisional; Region: PRK09201 1346614002566 Amidase; Region: Amidase; cl11426 1346614002567 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 1346614002568 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1346614002569 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1346614002570 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1346614002571 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1346614002572 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1346614002573 putative active site [active] 1346614002574 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1346614002575 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1346614002576 substrate binding pocket [chemical binding]; other site 1346614002577 membrane-bound complex binding site; other site 1346614002578 hinge residues; other site 1346614002579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614002580 dimer interface [polypeptide binding]; other site 1346614002581 conserved gate region; other site 1346614002582 putative PBP binding loops; other site 1346614002583 ABC-ATPase subunit interface; other site 1346614002584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614002585 ABC-ATPase subunit interface; other site 1346614002586 putative PBP binding loops; other site 1346614002587 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1346614002588 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1346614002589 Walker A/P-loop; other site 1346614002590 ATP binding site [chemical binding]; other site 1346614002591 Q-loop/lid; other site 1346614002592 ABC transporter signature motif; other site 1346614002593 Walker B; other site 1346614002594 D-loop; other site 1346614002595 H-loop/switch region; other site 1346614002596 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1346614002597 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1346614002598 catalytic residue [active] 1346614002599 allantoate amidohydrolase; Reviewed; Region: PRK09290 1346614002600 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1346614002601 active site 1346614002602 metal binding site [ion binding]; metal-binding site 1346614002603 dimer interface [polypeptide binding]; other site 1346614002604 OHCU decarboxylase; Region: UraD_2; TIGR03180 1346614002605 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1346614002606 active site 1346614002607 homotetramer interface [polypeptide binding]; other site 1346614002608 xanthine permease; Region: pbuX; TIGR03173 1346614002609 C-N hydrolase family amidase; Provisional; Region: PRK10438 1346614002610 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 1346614002611 putative active site [active] 1346614002612 catalytic triad [active] 1346614002613 dimer interface [polypeptide binding]; other site 1346614002614 multimer interface [polypeptide binding]; other site 1346614002615 methionine aminotransferase; Validated; Region: PRK09082 1346614002616 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1346614002617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614002618 homodimer interface [polypeptide binding]; other site 1346614002619 catalytic residue [active] 1346614002620 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 1346614002621 intersubunit interface [polypeptide binding]; other site 1346614002622 active site 1346614002623 Zn2+ binding site [ion binding]; other site 1346614002624 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 1346614002625 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1346614002626 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1346614002627 Cupin domain; Region: Cupin_2; cl17218 1346614002628 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1346614002629 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1346614002630 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 1346614002631 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1346614002632 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1346614002633 active site 1346614002634 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1346614002635 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1346614002636 dimer interface [polypeptide binding]; other site 1346614002637 active site 1346614002638 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1346614002639 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1346614002640 putative active site [active] 1346614002641 putative dimer interface [polypeptide binding]; other site 1346614002642 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1346614002643 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 1346614002644 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1346614002645 E3 interaction surface; other site 1346614002646 lipoyl attachment site [posttranslational modification]; other site 1346614002647 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 1346614002648 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 1346614002649 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 1346614002650 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 1346614002651 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 1346614002652 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 1346614002653 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 1346614002654 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1346614002655 catalytic loop [active] 1346614002656 iron binding site [ion binding]; other site 1346614002657 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 1346614002658 FAD binding pocket [chemical binding]; other site 1346614002659 FAD binding motif [chemical binding]; other site 1346614002660 phosphate binding motif [ion binding]; other site 1346614002661 beta-alpha-beta structure motif; other site 1346614002662 NAD binding pocket [chemical binding]; other site 1346614002663 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1346614002664 ApbE family; Region: ApbE; pfam02424 1346614002665 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991 1346614002666 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1346614002667 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1346614002668 active site 1346614002669 catalytic site [active] 1346614002670 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1346614002671 active site 1346614002672 DNA polymerase IV; Validated; Region: PRK02406 1346614002673 DNA binding site [nucleotide binding] 1346614002674 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 1346614002675 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 1346614002676 metal binding site [ion binding]; metal-binding site 1346614002677 dimer interface [polypeptide binding]; other site 1346614002678 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1346614002679 active site 1346614002680 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 1346614002681 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 1346614002682 gamma-glutamyl kinase; Provisional; Region: PRK05429 1346614002683 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1346614002684 nucleotide binding site [chemical binding]; other site 1346614002685 homotetrameric interface [polypeptide binding]; other site 1346614002686 putative phosphate binding site [ion binding]; other site 1346614002687 putative allosteric binding site; other site 1346614002688 PUA domain; Region: PUA; pfam01472 1346614002689 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1346614002690 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1346614002691 putative catalytic cysteine [active] 1346614002692 Protein of unknown function DUF91; Region: DUF91; cl00709 1346614002693 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1346614002694 sequence-specific DNA binding site [nucleotide binding]; other site 1346614002695 salt bridge; other site 1346614002696 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1346614002697 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1346614002698 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1346614002699 peptide binding site [polypeptide binding]; other site 1346614002700 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1346614002701 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1346614002702 Condensation domain; Region: Condensation; pfam00668 1346614002703 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1346614002704 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1346614002705 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1346614002706 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1346614002707 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1346614002708 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1346614002709 Condensation domain; Region: Condensation; pfam00668 1346614002710 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1346614002711 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1346614002712 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1346614002713 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1346614002714 catalytic residues [active] 1346614002715 hinge region; other site 1346614002716 alpha helical domain; other site 1346614002717 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 1346614002718 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614002719 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1346614002720 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1346614002721 NAD(P) binding site [chemical binding]; other site 1346614002722 catalytic residues [active] 1346614002723 leucine export protein LeuE; Provisional; Region: PRK10958 1346614002724 tellurite resistance protein TehB; Provisional; Region: PRK12335 1346614002725 Domain of unknown function (DUF1971); Region: DUF1971; cl17717 1346614002726 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614002727 S-adenosylmethionine binding site [chemical binding]; other site 1346614002728 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 1346614002729 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1346614002730 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1346614002731 dimer interface [polypeptide binding]; other site 1346614002732 PYR/PP interface [polypeptide binding]; other site 1346614002733 TPP binding site [chemical binding]; other site 1346614002734 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1346614002735 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1346614002736 TPP-binding site [chemical binding]; other site 1346614002737 dimer interface [polypeptide binding]; other site 1346614002738 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 1346614002739 hypothetical protein; Provisional; Region: PRK11667 1346614002740 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 1346614002741 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 1346614002742 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1346614002743 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1346614002744 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1346614002745 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1346614002746 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1346614002747 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1346614002748 active site 1346614002749 metal binding site [ion binding]; metal-binding site 1346614002750 LysR family transcriptional regulator; Provisional; Region: PRK14997 1346614002751 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614002752 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1346614002753 putative effector binding pocket; other site 1346614002754 putative dimerization interface [polypeptide binding]; other site 1346614002755 Pirin-related protein [General function prediction only]; Region: COG1741 1346614002756 Pirin; Region: Pirin; pfam02678 1346614002757 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1346614002758 Isochorismatase family; Region: Isochorismatase; pfam00857 1346614002759 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1346614002760 catalytic triad [active] 1346614002761 dimer interface [polypeptide binding]; other site 1346614002762 conserved cis-peptide bond; other site 1346614002763 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1346614002764 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1346614002765 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1346614002766 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 1346614002767 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 1346614002768 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1346614002769 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1346614002770 salt bridge; other site 1346614002771 non-specific DNA binding site [nucleotide binding]; other site 1346614002772 sequence-specific DNA binding site [nucleotide binding]; other site 1346614002773 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1346614002774 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614002775 S-adenosylmethionine binding site [chemical binding]; other site 1346614002776 aquaporin Z; Provisional; Region: PRK05420 1346614002777 amphipathic channel; other site 1346614002778 Asn-Pro-Ala signature motifs; other site 1346614002779 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 1346614002780 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1346614002781 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1346614002782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1346614002783 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1346614002784 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614002785 Coenzyme A binding pocket [chemical binding]; other site 1346614002786 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 1346614002787 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 1346614002788 putative ligand binding residues [chemical binding]; other site 1346614002789 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1346614002790 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1346614002791 N-terminal plug; other site 1346614002792 ligand-binding site [chemical binding]; other site 1346614002793 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1346614002794 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614002795 Coenzyme A binding pocket [chemical binding]; other site 1346614002796 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1346614002797 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1346614002798 ADP binding site [chemical binding]; other site 1346614002799 magnesium binding site [ion binding]; other site 1346614002800 putative shikimate binding site; other site 1346614002801 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1346614002802 active site 1346614002803 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1346614002804 catalytic tetrad [active] 1346614002805 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1346614002806 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1346614002807 Helix-turn-helix domain; Region: HTH_18; pfam12833 1346614002808 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614002809 SnoaL-like domain; Region: SnoaL_2; pfam12680 1346614002810 hypothetical protein; Provisional; Region: PRK10380 1346614002811 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1346614002812 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1346614002813 Bacterial transcriptional regulator; Region: IclR; pfam01614 1346614002814 OPT oligopeptide transporter protein; Region: OPT; cl14607 1346614002815 Protein of unknown function (DUF1177); Region: DUF1177; pfam06675 1346614002816 hypothetical protein; Provisional; Region: PRK10481 1346614002817 hypothetical protein; Provisional; Region: PRK10579 1346614002818 recombination associated protein; Reviewed; Region: rdgC; PRK00321 1346614002819 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1346614002820 dimerization interface [polypeptide binding]; other site 1346614002821 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1346614002822 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1346614002823 dimer interface [polypeptide binding]; other site 1346614002824 phosphorylation site [posttranslational modification] 1346614002825 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614002826 ATP binding site [chemical binding]; other site 1346614002827 Mg2+ binding site [ion binding]; other site 1346614002828 G-X-G motif; other site 1346614002829 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1346614002830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614002831 active site 1346614002832 phosphorylation site [posttranslational modification] 1346614002833 intermolecular recognition site; other site 1346614002834 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1346614002835 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1346614002836 Walker A/P-loop; other site 1346614002837 ATP binding site [chemical binding]; other site 1346614002838 Q-loop/lid; other site 1346614002839 ABC transporter signature motif; other site 1346614002840 Walker B; other site 1346614002841 D-loop; other site 1346614002842 H-loop/switch region; other site 1346614002843 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1346614002844 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1346614002845 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1346614002846 TM-ABC transporter signature motif; other site 1346614002847 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1346614002848 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 1346614002849 putative ligand binding site [chemical binding]; other site 1346614002850 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 1346614002851 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1346614002852 intersubunit interface [polypeptide binding]; other site 1346614002853 active site 1346614002854 zinc binding site [ion binding]; other site 1346614002855 Na+ binding site [ion binding]; other site 1346614002856 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1346614002857 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1346614002858 substrate binding site [chemical binding]; other site 1346614002859 ATP binding site [chemical binding]; other site 1346614002860 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1346614002861 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614002862 active site 1346614002863 phosphorylation site [posttranslational modification] 1346614002864 intermolecular recognition site; other site 1346614002865 dimerization interface [polypeptide binding]; other site 1346614002866 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1346614002867 DNA binding site [nucleotide binding] 1346614002868 fructokinase; Reviewed; Region: PRK09557 1346614002869 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1346614002870 nucleotide binding site [chemical binding]; other site 1346614002871 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1346614002872 CAT RNA binding domain; Region: CAT_RBD; smart01061 1346614002873 PRD domain; Region: PRD; pfam00874 1346614002874 PRD domain; Region: PRD; pfam00874 1346614002875 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1346614002876 AAA domain; Region: AAA_23; pfam13476 1346614002877 Walker A/P-loop; other site 1346614002878 ATP binding site [chemical binding]; other site 1346614002879 Q-loop/lid; other site 1346614002880 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1346614002881 ABC transporter signature motif; other site 1346614002882 Walker B; other site 1346614002883 D-loop; other site 1346614002884 H-loop/switch region; other site 1346614002885 exonuclease subunit SbcD; Provisional; Region: PRK10966 1346614002886 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1346614002887 active site 1346614002888 metal binding site [ion binding]; metal-binding site 1346614002889 DNA binding site [nucleotide binding] 1346614002890 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1346614002891 transcriptional regulator PhoB; Provisional; Region: PRK10161 1346614002892 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614002893 active site 1346614002894 phosphorylation site [posttranslational modification] 1346614002895 intermolecular recognition site; other site 1346614002896 dimerization interface [polypeptide binding]; other site 1346614002897 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1346614002898 DNA binding site [nucleotide binding] 1346614002899 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 1346614002900 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1346614002901 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1346614002902 putative active site [active] 1346614002903 heme pocket [chemical binding]; other site 1346614002904 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1346614002905 dimer interface [polypeptide binding]; other site 1346614002906 phosphorylation site [posttranslational modification] 1346614002907 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614002908 ATP binding site [chemical binding]; other site 1346614002909 Mg2+ binding site [ion binding]; other site 1346614002910 G-X-G motif; other site 1346614002911 PBP superfamily domain; Region: PBP_like_2; cl17296 1346614002912 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1346614002913 substrate binding site [chemical binding]; other site 1346614002914 THF binding site; other site 1346614002915 zinc-binding site [ion binding]; other site 1346614002916 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1346614002917 putative proline-specific permease; Provisional; Region: proY; PRK10580 1346614002918 Spore germination protein; Region: Spore_permease; cl17796 1346614002919 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1346614002920 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1346614002921 maltodextrin glucosidase; Provisional; Region: PRK10785 1346614002922 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1346614002923 homodimer interface [polypeptide binding]; other site 1346614002924 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1346614002925 active site 1346614002926 homodimer interface [polypeptide binding]; other site 1346614002927 catalytic site [active] 1346614002928 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1346614002929 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1346614002930 peroxidase; Provisional; Region: PRK15000 1346614002931 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1346614002932 dimer interface [polypeptide binding]; other site 1346614002933 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1346614002934 catalytic triad [active] 1346614002935 peroxidatic and resolving cysteines [active] 1346614002936 Protein of unknown function, DUF479; Region: DUF479; cl01203 1346614002937 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1346614002938 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1346614002939 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1346614002940 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1346614002941 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1346614002942 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1346614002943 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1346614002944 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1346614002945 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1346614002946 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1346614002947 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1346614002948 Protein export membrane protein; Region: SecD_SecF; pfam02355 1346614002949 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1346614002950 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614002951 active site 1346614002952 phosphorylation site [posttranslational modification] 1346614002953 intermolecular recognition site; other site 1346614002954 dimerization interface [polypeptide binding]; other site 1346614002955 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1346614002956 DNA binding residues [nucleotide binding] 1346614002957 dimerization interface [polypeptide binding]; other site 1346614002958 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1346614002959 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1346614002960 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1346614002961 dimer interface [polypeptide binding]; other site 1346614002962 phosphorylation site [posttranslational modification] 1346614002963 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614002964 ATP binding site [chemical binding]; other site 1346614002965 Mg2+ binding site [ion binding]; other site 1346614002966 G-X-G motif; other site 1346614002967 tetrathionate reductase subunit B; Provisional; Region: PRK14993 1346614002968 4Fe-4S binding domain; Region: Fer4; pfam00037 1346614002969 tetrathionate reductase subunit C; Provisional; Region: PRK14992 1346614002970 tetrathionate reductase subunit A; Provisional; Region: PRK14991 1346614002971 The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758 1346614002972 putative [Fe4-S4] binding site [ion binding]; other site 1346614002973 putative molybdopterin cofactor binding site [chemical binding]; other site 1346614002974 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 1346614002975 putative molybdopterin cofactor binding site; other site 1346614002976 hypothetical protein; Provisional; Region: PRK11530 1346614002977 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1346614002978 ATP cone domain; Region: ATP-cone; pfam03477 1346614002979 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1346614002980 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1346614002981 catalytic motif [active] 1346614002982 Zn binding site [ion binding]; other site 1346614002983 RibD C-terminal domain; Region: RibD_C; cl17279 1346614002984 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1346614002985 homopentamer interface [polypeptide binding]; other site 1346614002986 active site 1346614002987 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1346614002988 putative RNA binding site [nucleotide binding]; other site 1346614002989 thiamine monophosphate kinase; Provisional; Region: PRK05731 1346614002990 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1346614002991 ATP binding site [chemical binding]; other site 1346614002992 dimerization interface [polypeptide binding]; other site 1346614002993 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1346614002994 tetramer interfaces [polypeptide binding]; other site 1346614002995 binuclear metal-binding site [ion binding]; other site 1346614002996 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1346614002997 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1346614002998 active site 1346614002999 catalytic tetrad [active] 1346614003000 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1346614003001 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1346614003002 TPP-binding site; other site 1346614003003 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1346614003004 PYR/PP interface [polypeptide binding]; other site 1346614003005 dimer interface [polypeptide binding]; other site 1346614003006 TPP binding site [chemical binding]; other site 1346614003007 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1346614003008 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1346614003009 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1346614003010 substrate binding pocket [chemical binding]; other site 1346614003011 chain length determination region; other site 1346614003012 substrate-Mg2+ binding site; other site 1346614003013 catalytic residues [active] 1346614003014 aspartate-rich region 1; other site 1346614003015 active site lid residues [active] 1346614003016 aspartate-rich region 2; other site 1346614003017 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1346614003018 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 1346614003019 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1346614003020 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1346614003021 Ligand Binding Site [chemical binding]; other site 1346614003022 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1346614003023 active site residue [active] 1346614003024 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 1346614003025 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1346614003026 conserved cys residue [active] 1346614003027 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1346614003028 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1346614003029 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1346614003030 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1346614003031 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1346614003032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614003033 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1346614003034 putative substrate translocation pore; other site 1346614003035 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 1346614003036 UbiA prenyltransferase family; Region: UbiA; pfam01040 1346614003037 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 1346614003038 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1346614003039 Subunit III/IV interface [polypeptide binding]; other site 1346614003040 Subunit I/III interface [polypeptide binding]; other site 1346614003041 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1346614003042 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1346614003043 D-pathway; other site 1346614003044 Putative ubiquinol binding site [chemical binding]; other site 1346614003045 Low-spin heme (heme b) binding site [chemical binding]; other site 1346614003046 Putative water exit pathway; other site 1346614003047 Binuclear center (heme o3/CuB) [ion binding]; other site 1346614003048 K-pathway; other site 1346614003049 Putative proton exit pathway; other site 1346614003050 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 1346614003051 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1346614003052 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1346614003053 Acetyl-coenzyme A transporter 1; Region: Acatn; pfam13000 1346614003054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614003055 putative substrate translocation pore; other site 1346614003056 hypothetical protein; Provisional; Region: PRK11627 1346614003057 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 1346614003058 transcriptional regulator BolA; Provisional; Region: PRK11628 1346614003059 trigger factor; Provisional; Region: tig; PRK01490 1346614003060 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1346614003061 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1346614003062 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1346614003063 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1346614003064 oligomer interface [polypeptide binding]; other site 1346614003065 active site residues [active] 1346614003066 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1346614003067 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1346614003068 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1346614003069 Walker A motif; other site 1346614003070 ATP binding site [chemical binding]; other site 1346614003071 Walker B motif; other site 1346614003072 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1346614003073 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 1346614003074 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1346614003075 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1346614003076 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1346614003077 Walker A motif; other site 1346614003078 ATP binding site [chemical binding]; other site 1346614003079 Walker B motif; other site 1346614003080 arginine finger; other site 1346614003081 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1346614003082 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1346614003083 IHF dimer interface [polypeptide binding]; other site 1346614003084 IHF - DNA interface [nucleotide binding]; other site 1346614003085 periplasmic folding chaperone; Provisional; Region: PRK10788 1346614003086 SurA N-terminal domain; Region: SurA_N_3; cl07813 1346614003087 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1346614003088 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1346614003089 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1346614003090 active site 1346614003091 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1346614003092 Ligand Binding Site [chemical binding]; other site 1346614003093 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1346614003094 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1346614003095 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1346614003096 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 1346614003097 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1346614003098 active site 1346614003099 motif I; other site 1346614003100 motif II; other site 1346614003101 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1346614003102 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1346614003103 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1346614003104 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1346614003105 catalytic residue [active] 1346614003106 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1346614003107 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1346614003108 putative DNA binding site [nucleotide binding]; other site 1346614003109 putative Zn2+ binding site [ion binding]; other site 1346614003110 AsnC family; Region: AsnC_trans_reg; pfam01037 1346614003111 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1346614003112 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1346614003113 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1346614003114 Walker A/P-loop; other site 1346614003115 ATP binding site [chemical binding]; other site 1346614003116 Q-loop/lid; other site 1346614003117 ABC transporter signature motif; other site 1346614003118 Walker B; other site 1346614003119 D-loop; other site 1346614003120 H-loop/switch region; other site 1346614003121 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 1346614003122 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1346614003123 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1346614003124 Walker A/P-loop; other site 1346614003125 ATP binding site [chemical binding]; other site 1346614003126 Q-loop/lid; other site 1346614003127 ABC transporter signature motif; other site 1346614003128 Walker B; other site 1346614003129 D-loop; other site 1346614003130 H-loop/switch region; other site 1346614003131 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 1346614003132 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1346614003133 ammonium transporter; Provisional; Region: PRK10666 1346614003134 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1346614003135 MOSC domain; Region: MOSC; pfam03473 1346614003136 3-alpha domain; Region: 3-alpha; pfam03475 1346614003137 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 1346614003138 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1346614003139 catalytic triad [active] 1346614003140 acyl-CoA thioesterase II; Provisional; Region: PRK10526 1346614003141 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1346614003142 active site 1346614003143 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1346614003144 catalytic triad [active] 1346614003145 dimer interface [polypeptide binding]; other site 1346614003146 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 1346614003147 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1346614003148 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1346614003149 DNA binding site [nucleotide binding] 1346614003150 active site 1346614003151 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1346614003152 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1346614003153 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1346614003154 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1346614003155 active site 1346614003156 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1346614003157 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614003158 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614003159 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1346614003160 dimerization interface [polypeptide binding]; other site 1346614003161 gene expression modulator; Provisional; Region: PRK10945 1346614003162 Hha toxicity attenuator; Provisional; Region: PRK10667 1346614003163 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1346614003164 proposed F420-0 ABC transporter, ATP-binding protein; Region: F420-0_ABC_ATP; TIGR03873 1346614003165 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1346614003166 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1346614003167 ABC-ATPase subunit interface; other site 1346614003168 dimer interface [polypeptide binding]; other site 1346614003169 putative PBP binding regions; other site 1346614003170 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1346614003171 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1346614003172 metal binding site [ion binding]; metal-binding site 1346614003173 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1346614003174 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1346614003175 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1346614003176 Protein export membrane protein; Region: SecD_SecF; cl14618 1346614003177 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1346614003178 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1346614003179 HlyD family secretion protein; Region: HlyD_3; pfam13437 1346614003180 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 1346614003181 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1346614003182 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1346614003183 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 1346614003184 hypothetical protein; Provisional; Region: PRK11281 1346614003185 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1346614003186 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1346614003187 hypothetical protein; Provisional; Region: PRK11038 1346614003188 Primosomal replication protein priB and priC; Region: priB_priC; pfam07445 1346614003189 hypothetical protein; Provisional; Region: PRK10527 1346614003190 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1346614003191 active site 1346614003192 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 1346614003193 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1346614003194 Walker A motif; other site 1346614003195 ATP binding site [chemical binding]; other site 1346614003196 Walker B motif; other site 1346614003197 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1346614003198 arginine finger; other site 1346614003199 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1346614003200 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 1346614003201 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 1346614003202 hypothetical protein; Validated; Region: PRK00153 1346614003203 recombination protein RecR; Reviewed; Region: recR; PRK00076 1346614003204 RecR protein; Region: RecR; pfam02132 1346614003205 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1346614003206 putative active site [active] 1346614003207 putative metal-binding site [ion binding]; other site 1346614003208 tetramer interface [polypeptide binding]; other site 1346614003209 heat shock protein 90; Provisional; Region: PRK05218 1346614003210 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614003211 ATP binding site [chemical binding]; other site 1346614003212 Mg2+ binding site [ion binding]; other site 1346614003213 G-X-G motif; other site 1346614003214 adenylate kinase; Reviewed; Region: adk; PRK00279 1346614003215 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1346614003216 AMP-binding site [chemical binding]; other site 1346614003217 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1346614003218 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1346614003219 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1346614003220 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1346614003221 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1346614003222 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1346614003223 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1346614003224 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1346614003225 ferrochelatase; Reviewed; Region: hemH; PRK00035 1346614003226 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1346614003227 C-terminal domain interface [polypeptide binding]; other site 1346614003228 active site 1346614003229 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1346614003230 active site 1346614003231 N-terminal domain interface [polypeptide binding]; other site 1346614003232 inosine/guanosine kinase; Provisional; Region: PRK15074 1346614003233 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1346614003234 substrate binding site [chemical binding]; other site 1346614003235 ATP binding site [chemical binding]; other site 1346614003236 putative cation:proton antiport protein; Provisional; Region: PRK10669 1346614003237 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 1346614003238 TrkA-N domain; Region: TrkA_N; pfam02254 1346614003239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614003240 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1346614003241 putative substrate translocation pore; other site 1346614003242 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 1346614003243 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 1346614003244 active site 1346614003245 metal binding site [ion binding]; metal-binding site 1346614003246 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1346614003247 Phospholipid methyltransferase; Region: PEMT; cl17370 1346614003248 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1346614003249 putative deacylase active site [active] 1346614003250 TraB family; Region: TraB; cl12050 1346614003251 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1346614003252 metal-binding site [ion binding] 1346614003253 copper exporting ATPase; Provisional; Region: copA; PRK10671 1346614003254 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1346614003255 metal-binding site [ion binding] 1346614003256 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1346614003257 metal-binding site [ion binding] 1346614003258 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1346614003259 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1346614003260 motif II; other site 1346614003261 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 1346614003262 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1346614003263 DNA binding residues [nucleotide binding] 1346614003264 dimer interface [polypeptide binding]; other site 1346614003265 copper binding site [ion binding]; other site 1346614003266 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1346614003267 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1346614003268 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1346614003269 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 1346614003270 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614003271 S-adenosylmethionine binding site [chemical binding]; other site 1346614003272 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1346614003273 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1346614003274 oxidoreductase; Provisional; Region: PRK08017 1346614003275 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1346614003276 NADP binding site [chemical binding]; other site 1346614003277 active site 1346614003278 steroid binding site; other site 1346614003279 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1346614003280 active site 1346614003281 catalytic triad [active] 1346614003282 oxyanion hole [active] 1346614003283 switch loop; other site 1346614003284 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 1346614003285 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1346614003286 Walker A/P-loop; other site 1346614003287 ATP binding site [chemical binding]; other site 1346614003288 Q-loop/lid; other site 1346614003289 ABC transporter signature motif; other site 1346614003290 Walker B; other site 1346614003291 D-loop; other site 1346614003292 H-loop/switch region; other site 1346614003293 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1346614003294 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1346614003295 FtsX-like permease family; Region: FtsX; pfam02687 1346614003296 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1346614003297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614003298 putative substrate translocation pore; other site 1346614003299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614003300 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1346614003301 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1346614003302 NAD binding site [chemical binding]; other site 1346614003303 homodimer interface [polypeptide binding]; other site 1346614003304 active site 1346614003305 substrate binding site [chemical binding]; other site 1346614003306 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1346614003307 ATP-grasp domain; Region: ATP-grasp; pfam02222 1346614003308 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1346614003309 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1346614003310 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1346614003311 putative active site [active] 1346614003312 putative metal binding site [ion binding]; other site 1346614003313 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1346614003314 substrate binding site [chemical binding]; other site 1346614003315 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1346614003316 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1346614003317 active site 1346614003318 HIGH motif; other site 1346614003319 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1346614003320 KMSKS motif; other site 1346614003321 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1346614003322 tRNA binding surface [nucleotide binding]; other site 1346614003323 anticodon binding site; other site 1346614003324 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1346614003325 RNA binding surface [nucleotide binding]; other site 1346614003326 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1346614003327 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1346614003328 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1346614003329 homodimer interface [polypeptide binding]; other site 1346614003330 NADP binding site [chemical binding]; other site 1346614003331 substrate binding site [chemical binding]; other site 1346614003332 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1346614003333 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 1346614003334 Int/Topo IB signature motif; other site 1346614003335 Antitermination protein; Region: Antiterm; pfam03589 1346614003336 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1346614003337 Fic/DOC family; Region: Fic; cl00960 1346614003338 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 1346614003339 Cupin domain; Region: Cupin_2; cl17218 1346614003340 Predicted membrane protein [Function unknown]; Region: COG2259 1346614003341 short chain dehydrogenase; Provisional; Region: PRK08303 1346614003342 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1346614003343 NAD(P) binding site [chemical binding]; other site 1346614003344 active site 1346614003345 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 1346614003346 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1346614003347 putative NAD(P) binding site [chemical binding]; other site 1346614003348 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1346614003349 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1346614003350 putative NAD(P) binding site [chemical binding]; other site 1346614003351 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614003352 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614003353 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1346614003354 putative effector binding pocket; other site 1346614003355 dimerization interface [polypeptide binding]; other site 1346614003356 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1346614003357 dimerization interface [polypeptide binding]; other site 1346614003358 putative active site pocket [active] 1346614003359 putative catalytic residue [active] 1346614003360 Amidohydrolase; Region: Amidohydro_2; pfam04909 1346614003361 3-hydroxyanthranilic acid dioxygenase; Region: 3-HAO; cl17399 1346614003362 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1346614003363 homotrimer interaction site [polypeptide binding]; other site 1346614003364 putative active site [active] 1346614003365 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1346614003366 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1346614003367 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1346614003368 active site 1346614003369 catalytic residues [active] 1346614003370 metal binding site [ion binding]; metal-binding site 1346614003371 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1346614003372 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1346614003373 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1346614003374 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1346614003375 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1346614003376 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1346614003377 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614003378 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1346614003379 dimerization interface [polypeptide binding]; other site 1346614003380 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 1346614003381 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1346614003382 NAD binding site [chemical binding]; other site 1346614003383 catalytic residues [active] 1346614003384 benzoate transport; Region: 2A0115; TIGR00895 1346614003385 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614003386 putative substrate translocation pore; other site 1346614003387 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1346614003388 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1346614003389 active site 1346614003390 catalytic tetrad [active] 1346614003391 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614003392 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614003393 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1346614003394 putative effector binding pocket; other site 1346614003395 putative dimerization interface [polypeptide binding]; other site 1346614003396 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1346614003397 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1346614003398 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1346614003399 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1346614003400 metal binding site [ion binding]; metal-binding site 1346614003401 active site 1346614003402 I-site; other site 1346614003403 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1346614003404 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1346614003405 DNA-binding site [nucleotide binding]; DNA binding site 1346614003406 RNA-binding motif; other site 1346614003407 The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6, and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348 1346614003408 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1346614003409 putative active site [active] 1346614003410 putative metal binding site [ion binding]; other site 1346614003411 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1346614003412 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1346614003413 Walker A/P-loop; other site 1346614003414 ATP binding site [chemical binding]; other site 1346614003415 Q-loop/lid; other site 1346614003416 ABC transporter signature motif; other site 1346614003417 Walker B; other site 1346614003418 D-loop; other site 1346614003419 H-loop/switch region; other site 1346614003420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614003421 dimer interface [polypeptide binding]; other site 1346614003422 conserved gate region; other site 1346614003423 putative PBP binding loops; other site 1346614003424 ABC-ATPase subunit interface; other site 1346614003425 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1346614003426 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614003427 Coenzyme A binding pocket [chemical binding]; other site 1346614003428 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1346614003429 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1346614003430 substrate binding pocket [chemical binding]; other site 1346614003431 membrane-bound complex binding site; other site 1346614003432 hinge residues; other site 1346614003433 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1346614003434 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1346614003435 active site 1346614003436 non-prolyl cis peptide bond; other site 1346614003437 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1346614003438 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1346614003439 metal binding site [ion binding]; metal-binding site 1346614003440 dimer interface [polypeptide binding]; other site 1346614003441 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1346614003442 DNA-binding site [nucleotide binding]; DNA binding site 1346614003443 RNA-binding motif; other site 1346614003444 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1346614003445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614003446 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1346614003447 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1346614003448 chromosome condensation membrane protein; Provisional; Region: PRK14196 1346614003449 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 1346614003450 MASE2 domain; Region: MASE2; pfam05230 1346614003451 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1346614003452 metal binding site [ion binding]; metal-binding site 1346614003453 active site 1346614003454 I-site; other site 1346614003455 twin arginine translocase protein A; Validated; Region: tatE; PRK01614 1346614003456 lipoyl synthase; Provisional; Region: PRK05481 1346614003457 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1346614003458 FeS/SAM binding site; other site 1346614003459 lipoate-protein ligase B; Provisional; Region: PRK14342 1346614003460 hypothetical protein; Provisional; Region: PRK04998 1346614003461 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 1346614003462 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1346614003463 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1346614003464 rare lipoprotein A; Provisional; Region: PRK10672 1346614003465 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1346614003466 Sporulation related domain; Region: SPOR; pfam05036 1346614003467 cell wall shape-determining protein; Provisional; Region: PRK10794 1346614003468 penicillin-binding protein 2; Provisional; Region: PRK10795 1346614003469 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1346614003470 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1346614003471 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 1346614003472 ribosome-associated protein; Provisional; Region: PRK11538 1346614003473 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1346614003474 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1346614003475 active site 1346614003476 (T/H)XGH motif; other site 1346614003477 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1346614003478 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1346614003479 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 1346614003480 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1346614003481 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1346614003482 HIGH motif; other site 1346614003483 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1346614003484 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1346614003485 active site 1346614003486 KMSKS motif; other site 1346614003487 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1346614003488 tRNA binding surface [nucleotide binding]; other site 1346614003489 hypothetical protein; Provisional; Region: PRK11032 1346614003490 Predicted integral membrane metal-binding protein (DUF2296); Region: DUF2296; pfam10058 1346614003491 azoreductase; Reviewed; Region: PRK00170 1346614003492 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1346614003493 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1346614003494 active site 1346614003495 tetramer interface [polypeptide binding]; other site 1346614003496 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1346614003497 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1346614003498 Walker A/P-loop; other site 1346614003499 ATP binding site [chemical binding]; other site 1346614003500 Q-loop/lid; other site 1346614003501 ABC transporter signature motif; other site 1346614003502 Walker B; other site 1346614003503 D-loop; other site 1346614003504 H-loop/switch region; other site 1346614003505 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1346614003506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614003507 dimer interface [polypeptide binding]; other site 1346614003508 conserved gate region; other site 1346614003509 putative PBP binding loops; other site 1346614003510 ABC-ATPase subunit interface; other site 1346614003511 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1346614003512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614003513 dimer interface [polypeptide binding]; other site 1346614003514 conserved gate region; other site 1346614003515 putative PBP binding loops; other site 1346614003516 ABC-ATPase subunit interface; other site 1346614003517 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1346614003518 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1346614003519 substrate binding pocket [chemical binding]; other site 1346614003520 membrane-bound complex binding site; other site 1346614003521 hinge residues; other site 1346614003522 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1346614003523 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1346614003524 putative active site [active] 1346614003525 catalytic triad [active] 1346614003526 putative dimer interface [polypeptide binding]; other site 1346614003527 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 1346614003528 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1346614003529 Transporter associated domain; Region: CorC_HlyC; smart01091 1346614003530 metal-binding heat shock protein; Provisional; Region: PRK00016 1346614003531 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1346614003532 PhoH-like protein; Region: PhoH; pfam02562 1346614003533 hypothetical protein; Provisional; Region: PRK10220 1346614003534 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1346614003535 PhnA protein; Region: PhnA; pfam03831 1346614003536 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1346614003537 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1346614003538 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1346614003539 FeS/SAM binding site; other site 1346614003540 TRAM domain; Region: TRAM; pfam01938 1346614003541 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 1346614003542 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1346614003543 asparagine synthetase B; Provisional; Region: asnB; PRK09431 1346614003544 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1346614003545 active site 1346614003546 dimer interface [polypeptide binding]; other site 1346614003547 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1346614003548 Ligand Binding Site [chemical binding]; other site 1346614003549 Molecular Tunnel; other site 1346614003550 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 1346614003551 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 1346614003552 putative active site [active] 1346614003553 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 1346614003554 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1346614003555 Interdomain contacts; other site 1346614003556 Cytokine receptor motif; other site 1346614003557 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 1346614003558 UMP phosphatase; Provisional; Region: PRK10444 1346614003559 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1346614003560 active site 1346614003561 motif I; other site 1346614003562 motif II; other site 1346614003563 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1346614003564 MarR family; Region: MarR; pfam01047 1346614003565 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1346614003566 ROK family; Region: ROK; pfam00480 1346614003567 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1346614003568 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1346614003569 active site 1346614003570 dimer interface [polypeptide binding]; other site 1346614003571 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1346614003572 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1346614003573 active site 1346614003574 trimer interface [polypeptide binding]; other site 1346614003575 allosteric site; other site 1346614003576 active site lid [active] 1346614003577 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1346614003578 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 1346614003579 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1346614003580 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1346614003581 active site turn [active] 1346614003582 phosphorylation site [posttranslational modification] 1346614003583 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1346614003584 HPr interaction site; other site 1346614003585 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1346614003586 active site 1346614003587 phosphorylation site [posttranslational modification] 1346614003588 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1346614003589 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1346614003590 active site 1346614003591 HIGH motif; other site 1346614003592 nucleotide binding site [chemical binding]; other site 1346614003593 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1346614003594 KMSKS motif; other site 1346614003595 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1346614003596 outer membrane porin, OprD family; Region: OprD; pfam03573 1346614003597 YbfN-like lipoprotein; Region: YbfN; pfam13982 1346614003598 Putative carbohydrate binding domain; Region: CHB_HEX; smart01081 1346614003599 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 1346614003600 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 1346614003601 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a...; Region: GH20_Sm-chitobiase-like; cd06569 1346614003602 active site 1346614003603 C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847 1346614003604 ferric uptake regulator; Provisional; Region: fur; PRK09462 1346614003605 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1346614003606 metal binding site 2 [ion binding]; metal-binding site 1346614003607 putative DNA binding helix; other site 1346614003608 metal binding site 1 [ion binding]; metal-binding site 1346614003609 dimer interface [polypeptide binding]; other site 1346614003610 structural Zn2+ binding site [ion binding]; other site 1346614003611 flavodoxin FldA; Validated; Region: PRK09267 1346614003612 LexA regulated protein; Provisional; Region: PRK11675 1346614003613 acyl-CoA esterase; Provisional; Region: PRK10673 1346614003614 PGAP1-like protein; Region: PGAP1; pfam07819 1346614003615 replication initiation regulator SeqA; Provisional; Region: PRK11187 1346614003616 phosphoglucomutase; Validated; Region: PRK07564 1346614003617 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1346614003618 active site 1346614003619 substrate binding site [chemical binding]; other site 1346614003620 metal binding site [ion binding]; metal-binding site 1346614003621 Predicted transcriptional regulators [Transcription]; Region: COG1695 1346614003622 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1346614003623 Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977 1346614003624 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1346614003625 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614003626 active site 1346614003627 phosphorylation site [posttranslational modification] 1346614003628 intermolecular recognition site; other site 1346614003629 dimerization interface [polypeptide binding]; other site 1346614003630 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1346614003631 DNA binding site [nucleotide binding] 1346614003632 sensor protein KdpD; Provisional; Region: PRK10490 1346614003633 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1346614003634 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1346614003635 Ligand Binding Site [chemical binding]; other site 1346614003636 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1346614003637 GAF domain; Region: GAF_3; pfam13492 1346614003638 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1346614003639 dimer interface [polypeptide binding]; other site 1346614003640 phosphorylation site [posttranslational modification] 1346614003641 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614003642 ATP binding site [chemical binding]; other site 1346614003643 Mg2+ binding site [ion binding]; other site 1346614003644 G-X-G motif; other site 1346614003645 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1346614003646 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1346614003647 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1346614003648 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1346614003649 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 1346614003650 Protein of unknown function (DUF523); Region: DUF523; pfam04463 1346614003651 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1346614003652 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 1346614003653 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 1346614003654 DNA photolyase; Region: DNA_photolyase; pfam00875 1346614003655 cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776 1346614003656 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1346614003657 metal-binding protein; Provisional; Region: PRK10799 1346614003658 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1346614003659 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1346614003660 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1346614003661 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 1346614003662 putative active site [active] 1346614003663 Protein of unknown function (DUF969); Region: DUF969; pfam06149 1346614003664 Predicted membrane protein [Function unknown]; Region: COG3817 1346614003665 Protein of unknown function (DUF979); Region: DUF979; pfam06166 1346614003666 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1346614003667 putative substrate binding pocket [chemical binding]; other site 1346614003668 AC domain interface; other site 1346614003669 catalytic triad [active] 1346614003670 AB domain interface; other site 1346614003671 endonuclease VIII; Provisional; Region: PRK10445 1346614003672 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 1346614003673 DNA binding site [nucleotide binding] 1346614003674 catalytic residue [active] 1346614003675 H2TH interface [polypeptide binding]; other site 1346614003676 putative catalytic residues [active] 1346614003677 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1346614003678 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1346614003679 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1346614003680 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1346614003681 dimer interface [polypeptide binding]; other site 1346614003682 active site 1346614003683 citrylCoA binding site [chemical binding]; other site 1346614003684 NADH binding [chemical binding]; other site 1346614003685 cationic pore residues; other site 1346614003686 oxalacetate/citrate binding site [chemical binding]; other site 1346614003687 coenzyme A binding site [chemical binding]; other site 1346614003688 catalytic triad [active] 1346614003689 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1346614003690 Iron-sulfur protein interface; other site 1346614003691 proximal quinone binding site [chemical binding]; other site 1346614003692 SdhD (CybS) interface [polypeptide binding]; other site 1346614003693 proximal heme binding site [chemical binding]; other site 1346614003694 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1346614003695 SdhC subunit interface [polypeptide binding]; other site 1346614003696 proximal heme binding site [chemical binding]; other site 1346614003697 cardiolipin binding site; other site 1346614003698 Iron-sulfur protein interface; other site 1346614003699 proximal quinone binding site [chemical binding]; other site 1346614003700 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 1346614003701 L-aspartate oxidase; Provisional; Region: PRK06175 1346614003702 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1346614003703 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1346614003704 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1346614003705 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1346614003706 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1346614003707 TPP-binding site [chemical binding]; other site 1346614003708 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1346614003709 dimer interface [polypeptide binding]; other site 1346614003710 PYR/PP interface [polypeptide binding]; other site 1346614003711 TPP binding site [chemical binding]; other site 1346614003712 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1346614003713 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1346614003714 E3 interaction surface; other site 1346614003715 lipoyl attachment site [posttranslational modification]; other site 1346614003716 e3 binding domain; Region: E3_binding; pfam02817 1346614003717 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1346614003718 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1346614003719 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1346614003720 CoA-ligase; Region: Ligase_CoA; pfam00549 1346614003721 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1346614003722 CoA binding domain; Region: CoA_binding; smart00881 1346614003723 CoA-ligase; Region: Ligase_CoA; pfam00549 1346614003724 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1346614003725 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1346614003726 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1346614003727 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1346614003728 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 1346614003729 hypothetical protein; Provisional; Region: PRK10588 1346614003730 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1346614003731 active site 1346614003732 colicin uptake protein TolQ; Provisional; Region: PRK10801 1346614003733 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1346614003734 colicin uptake protein TolR; Provisional; Region: PRK11024 1346614003735 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 1346614003736 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 1346614003737 TolA C-terminal; Region: TolA; pfam06519 1346614003738 translocation protein TolB; Provisional; Region: tolB; PRK03629 1346614003739 TolB amino-terminal domain; Region: TolB_N; pfam04052 1346614003740 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1346614003741 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1346614003742 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1346614003743 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 1346614003744 Serglycin; Region: Serglycin; pfam04360 1346614003745 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1346614003746 ligand binding site [chemical binding]; other site 1346614003747 tol-pal system protein YbgF; Provisional; Region: PRK10803 1346614003748 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1346614003749 quinolinate synthetase; Provisional; Region: PRK09375 1346614003750 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 1346614003751 zinc transporter ZitB; Provisional; Region: PRK03557 1346614003752 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1346614003753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614003754 active site 1346614003755 phosphorylation site [posttranslational modification] 1346614003756 intermolecular recognition site; other site 1346614003757 dimerization interface [polypeptide binding]; other site 1346614003758 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1346614003759 DNA binding residues [nucleotide binding] 1346614003760 dimerization interface [polypeptide binding]; other site 1346614003761 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1346614003762 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1346614003763 Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987 1346614003764 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1346614003765 catalytic core [active] 1346614003766 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1346614003767 psiF repeat; Region: PsiF_repeat; pfam07769 1346614003768 psiF repeat; Region: PsiF_repeat; pfam07769 1346614003769 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1346614003770 active site 1346614003771 catalytic residues [active] 1346614003772 galactokinase; Provisional; Region: PRK05101 1346614003773 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1346614003774 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1346614003775 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 1346614003776 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1346614003777 dimer interface [polypeptide binding]; other site 1346614003778 active site 1346614003779 CAAX protease self-immunity; Region: Abi; pfam02517 1346614003780 Isochorismatase family; Region: Isochorismatase; pfam00857 1346614003781 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1346614003782 catalytic triad [active] 1346614003783 conserved cis-peptide bond; other site 1346614003784 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 1346614003785 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1346614003786 Walker A/P-loop; other site 1346614003787 ATP binding site [chemical binding]; other site 1346614003788 Q-loop/lid; other site 1346614003789 ABC transporter signature motif; other site 1346614003790 Walker B; other site 1346614003791 D-loop; other site 1346614003792 H-loop/switch region; other site 1346614003793 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1346614003794 Walker A/P-loop; other site 1346614003795 ATP binding site [chemical binding]; other site 1346614003796 Q-loop/lid; other site 1346614003797 ABC transporter signature motif; other site 1346614003798 Walker B; other site 1346614003799 D-loop; other site 1346614003800 H-loop/switch region; other site 1346614003801 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1346614003802 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1346614003803 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1346614003804 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1346614003805 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1346614003806 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1346614003807 N-terminal plug; other site 1346614003808 ligand-binding site [chemical binding]; other site 1346614003809 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1346614003810 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1346614003811 intersubunit interface [polypeptide binding]; other site 1346614003812 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1346614003813 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614003814 S-adenosylmethionine binding site [chemical binding]; other site 1346614003815 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1346614003816 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1346614003817 dimer interface [polypeptide binding]; other site 1346614003818 putative PBP binding regions; other site 1346614003819 ABC-ATPase subunit interface; other site 1346614003820 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1346614003821 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1346614003822 Walker A/P-loop; other site 1346614003823 ATP binding site [chemical binding]; other site 1346614003824 Q-loop/lid; other site 1346614003825 ABC transporter signature motif; other site 1346614003826 Walker B; other site 1346614003827 D-loop; other site 1346614003828 H-loop/switch region; other site 1346614003829 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 1346614003830 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 1346614003831 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1346614003832 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1346614003833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614003834 dimer interface [polypeptide binding]; other site 1346614003835 conserved gate region; other site 1346614003836 putative PBP binding loops; other site 1346614003837 ABC-ATPase subunit interface; other site 1346614003838 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 1346614003839 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1346614003840 Walker A/P-loop; other site 1346614003841 ATP binding site [chemical binding]; other site 1346614003842 Q-loop/lid; other site 1346614003843 ABC transporter signature motif; other site 1346614003844 Walker B; other site 1346614003845 D-loop; other site 1346614003846 H-loop/switch region; other site 1346614003847 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1346614003848 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 1346614003849 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1346614003850 active site 1346614003851 motif I; other site 1346614003852 motif II; other site 1346614003853 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1346614003854 6-phosphogluconolactonase; Provisional; Region: PRK11028 1346614003855 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1346614003856 substrate binding site [chemical binding]; other site 1346614003857 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1346614003858 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 1346614003859 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1346614003860 inhibitor-cofactor binding pocket; inhibition site 1346614003861 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614003862 catalytic residue [active] 1346614003863 biotin synthase; Provisional; Region: PRK15108 1346614003864 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1346614003865 FeS/SAM binding site; other site 1346614003866 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1346614003867 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1346614003868 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1346614003869 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1346614003870 catalytic residue [active] 1346614003871 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1346614003872 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614003873 S-adenosylmethionine binding site [chemical binding]; other site 1346614003874 AAA domain; Region: AAA_26; pfam13500 1346614003875 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1346614003876 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 1346614003877 ADP binding site [chemical binding]; other site 1346614003878 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1346614003879 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1346614003880 Walker A/P-loop; other site 1346614003881 ATP binding site [chemical binding]; other site 1346614003882 Q-loop/lid; other site 1346614003883 ABC transporter signature motif; other site 1346614003884 Walker B; other site 1346614003885 D-loop; other site 1346614003886 H-loop/switch region; other site 1346614003887 excinuclease ABC subunit B; Provisional; Region: PRK05298 1346614003888 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1346614003889 ATP binding site [chemical binding]; other site 1346614003890 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1346614003891 nucleotide binding region [chemical binding]; other site 1346614003892 ATP-binding site [chemical binding]; other site 1346614003893 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1346614003894 UvrB/uvrC motif; Region: UVR; pfam02151 1346614003895 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 1346614003896 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1346614003897 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1346614003898 phosphate binding site [ion binding]; other site 1346614003899 putative substrate binding pocket [chemical binding]; other site 1346614003900 dimer interface [polypeptide binding]; other site 1346614003901 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1346614003902 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1346614003903 FeS/SAM binding site; other site 1346614003904 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1346614003905 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1346614003906 MPT binding site; other site 1346614003907 trimer interface [polypeptide binding]; other site 1346614003908 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1346614003909 trimer interface [polypeptide binding]; other site 1346614003910 dimer interface [polypeptide binding]; other site 1346614003911 putative active site [active] 1346614003912 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1346614003913 MoaE interaction surface [polypeptide binding]; other site 1346614003914 MoeB interaction surface [polypeptide binding]; other site 1346614003915 thiocarboxylated glycine; other site 1346614003916 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1346614003917 MoaE homodimer interface [polypeptide binding]; other site 1346614003918 MoaD interaction [polypeptide binding]; other site 1346614003919 active site residues [active] 1346614003920 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1346614003921 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1346614003922 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1346614003923 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1346614003924 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1346614003925 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1346614003926 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1346614003927 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1346614003928 Walker A/P-loop; other site 1346614003929 ATP binding site [chemical binding]; other site 1346614003930 Q-loop/lid; other site 1346614003931 ABC transporter signature motif; other site 1346614003932 Walker B; other site 1346614003933 D-loop; other site 1346614003934 H-loop/switch region; other site 1346614003935 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1346614003936 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1346614003937 Walker A/P-loop; other site 1346614003938 ATP binding site [chemical binding]; other site 1346614003939 Q-loop/lid; other site 1346614003940 ABC transporter signature motif; other site 1346614003941 Walker B; other site 1346614003942 D-loop; other site 1346614003943 H-loop/switch region; other site 1346614003944 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1346614003945 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1346614003946 HlyD family secretion protein; Region: HlyD_3; pfam13437 1346614003947 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 1346614003948 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1346614003949 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1346614003950 helicase 45; Provisional; Region: PTZ00424 1346614003951 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1346614003952 ATP binding site [chemical binding]; other site 1346614003953 Mg++ binding site [ion binding]; other site 1346614003954 motif III; other site 1346614003955 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1346614003956 nucleotide binding region [chemical binding]; other site 1346614003957 ATP-binding site [chemical binding]; other site 1346614003958 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1346614003959 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1346614003960 HlyD family secretion protein; Region: HlyD_3; pfam13437 1346614003961 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1346614003962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614003963 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1346614003964 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1346614003965 Bacterial transcriptional regulator; Region: IclR; pfam01614 1346614003966 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1346614003967 Ligand Binding Site [chemical binding]; other site 1346614003968 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 1346614003969 dimerization interface [polypeptide binding]; other site 1346614003970 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1346614003971 NAD binding site [chemical binding]; other site 1346614003972 ligand binding site [chemical binding]; other site 1346614003973 catalytic site [active] 1346614003974 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 1346614003975 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1346614003976 FMN binding site [chemical binding]; other site 1346614003977 active site 1346614003978 catalytic residues [active] 1346614003979 substrate binding site [chemical binding]; other site 1346614003980 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 1346614003981 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1346614003982 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614003983 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1346614003984 dimerization interface [polypeptide binding]; other site 1346614003985 EamA-like transporter family; Region: EamA; cl17759 1346614003986 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1346614003987 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1346614003988 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1346614003989 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 1346614003990 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1346614003991 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614003992 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1346614003993 dimerization interface [polypeptide binding]; other site 1346614003994 substrate binding pocket [chemical binding]; other site 1346614003995 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1346614003996 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1346614003997 Predicted membrane protein [Function unknown]; Region: COG4125 1346614003998 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1346614003999 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1346614004000 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614004001 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614004002 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1346614004003 dimerization interface [polypeptide binding]; other site 1346614004004 LysE type translocator; Region: LysE; cl00565 1346614004005 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1346614004006 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1346614004007 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1346614004008 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1346614004009 conserved cys residue [active] 1346614004010 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1346614004011 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1346614004012 conserved cys residue [active] 1346614004013 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614004014 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1346614004015 NAD binding site [chemical binding]; other site 1346614004016 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 1346614004017 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1346614004018 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614004019 Coenzyme A binding pocket [chemical binding]; other site 1346614004020 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1346614004021 dimer interface [polypeptide binding]; other site 1346614004022 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1346614004023 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1346614004024 dimer interface [polypeptide binding]; other site 1346614004025 phosphorylation site [posttranslational modification] 1346614004026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614004027 ATP binding site [chemical binding]; other site 1346614004028 Mg2+ binding site [ion binding]; other site 1346614004029 G-X-G motif; other site 1346614004030 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1346614004031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614004032 active site 1346614004033 phosphorylation site [posttranslational modification] 1346614004034 intermolecular recognition site; other site 1346614004035 dimerization interface [polypeptide binding]; other site 1346614004036 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1346614004037 DNA binding residues [nucleotide binding] 1346614004038 dimerization interface [polypeptide binding]; other site 1346614004039 Domain of unknown function (DUF336); Region: DUF336; pfam03928 1346614004040 Protein of unknown function (DUF808); Region: DUF808; pfam05661 1346614004041 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1346614004042 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614004043 Coenzyme A binding pocket [chemical binding]; other site 1346614004044 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 1346614004045 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1346614004046 DNA binding residues [nucleotide binding] 1346614004047 putative dimer interface [polypeptide binding]; other site 1346614004048 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1346614004049 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1346614004050 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1346614004051 cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976 1346614004052 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1346614004053 catalytic residue [active] 1346614004054 Biofilm formation and stress response factor; Region: BsmA; pfam10014 1346614004055 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 1346614004056 lipoprotein, YaeC family; Region: TIGR00363 1346614004057 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 1346614004058 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1346614004059 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614004060 Coenzyme A binding pocket [chemical binding]; other site 1346614004061 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 1346614004062 putative trimer interface [polypeptide binding]; other site 1346614004063 putative active site [active] 1346614004064 putative substrate binding site [chemical binding]; other site 1346614004065 putative CoA binding site [chemical binding]; other site 1346614004066 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 1346614004067 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1346614004068 Flavodoxin; Region: Flavodoxin_1; pfam00258 1346614004069 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1346614004070 FAD binding pocket [chemical binding]; other site 1346614004071 conserved FAD binding motif [chemical binding]; other site 1346614004072 phosphate binding motif [ion binding]; other site 1346614004073 beta-alpha-beta structure motif; other site 1346614004074 NAD binding pocket [chemical binding]; other site 1346614004075 PAS domain; Region: PAS_9; pfam13426 1346614004076 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1346614004077 putative active site [active] 1346614004078 heme pocket [chemical binding]; other site 1346614004079 D-lactate dehydrogenase; Provisional; Region: PRK11183 1346614004080 FAD binding domain; Region: FAD_binding_4; pfam01565 1346614004081 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 1346614004082 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1346614004083 active site 1346614004084 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 1346614004085 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1346614004086 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1346614004087 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1346614004088 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1346614004089 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1346614004090 substrate binding pocket [chemical binding]; other site 1346614004091 membrane-bound complex binding site; other site 1346614004092 hinge residues; other site 1346614004093 putative aminotransferase; Provisional; Region: PRK12414 1346614004094 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1346614004095 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614004096 homodimer interface [polypeptide binding]; other site 1346614004097 catalytic residue [active] 1346614004098 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1346614004099 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614004100 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1346614004101 dimerization interface [polypeptide binding]; other site 1346614004102 substrate binding pocket [chemical binding]; other site 1346614004103 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1346614004104 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1346614004105 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1346614004106 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 1346614004107 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1346614004108 putative ligand binding residues [chemical binding]; other site 1346614004109 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1346614004110 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1346614004111 ABC-ATPase subunit interface; other site 1346614004112 dimer interface [polypeptide binding]; other site 1346614004113 putative PBP binding regions; other site 1346614004114 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1346614004115 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1346614004116 Walker A/P-loop; other site 1346614004117 ATP binding site [chemical binding]; other site 1346614004118 Q-loop/lid; other site 1346614004119 ABC transporter signature motif; other site 1346614004120 Walker B; other site 1346614004121 D-loop; other site 1346614004122 H-loop/switch region; other site 1346614004123 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1346614004124 molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537 1346614004125 ParA-like protein; Provisional; Region: PHA02518 1346614004126 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1346614004127 P-loop; other site 1346614004128 Magnesium ion binding site [ion binding]; other site 1346614004129 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1346614004130 active site 1346614004131 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614004132 Coenzyme A binding pocket [chemical binding]; other site 1346614004133 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614004134 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614004135 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1346614004136 putative effector binding pocket; other site 1346614004137 putative dimerization interface [polypeptide binding]; other site 1346614004138 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1346614004139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614004140 putative substrate translocation pore; other site 1346614004141 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 1346614004142 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 1346614004143 putative N- and C-terminal domain interface [polypeptide binding]; other site 1346614004144 putative active site [active] 1346614004145 putative MgATP binding site [chemical binding]; other site 1346614004146 catalytic site [active] 1346614004147 metal binding site [ion binding]; metal-binding site 1346614004148 putative carbohydrate binding site [chemical binding]; other site 1346614004149 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 1346614004150 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1346614004151 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1346614004152 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1346614004153 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614004154 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614004155 Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718 1346614004156 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 1346614004157 ATP binding site [chemical binding]; other site 1346614004158 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1346614004159 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1346614004160 active site 1346614004161 Na/Ca binding site [ion binding]; other site 1346614004162 catalytic site [active] 1346614004163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4380 1346614004164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 1346614004165 Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462 1346614004166 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1346614004167 MarR family; Region: MarR_2; cl17246 1346614004168 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1346614004169 Coenzyme A binding pocket [chemical binding]; other site 1346614004170 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1346614004171 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 1346614004172 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1346614004173 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1346614004174 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1346614004175 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1346614004176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614004177 dimer interface [polypeptide binding]; other site 1346614004178 conserved gate region; other site 1346614004179 putative PBP binding loops; other site 1346614004180 ABC-ATPase subunit interface; other site 1346614004181 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1346614004182 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1346614004183 Walker A/P-loop; other site 1346614004184 ATP binding site [chemical binding]; other site 1346614004185 Q-loop/lid; other site 1346614004186 ABC transporter signature motif; other site 1346614004187 Walker B; other site 1346614004188 D-loop; other site 1346614004189 H-loop/switch region; other site 1346614004190 NIL domain; Region: NIL; pfam09383 1346614004191 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1346614004192 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614004193 Coenzyme A binding pocket [chemical binding]; other site 1346614004194 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614004195 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614004196 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 1346614004197 putative effector binding pocket; other site 1346614004198 putative dimerization interface [polypeptide binding]; other site 1346614004199 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1346614004200 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1346614004201 NADP binding site [chemical binding]; other site 1346614004202 dimer interface [polypeptide binding]; other site 1346614004203 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1346614004204 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1346614004205 Isochorismatase family; Region: Isochorismatase; pfam00857 1346614004206 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1346614004207 catalytic triad [active] 1346614004208 conserved cis-peptide bond; other site 1346614004209 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1346614004210 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1346614004211 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1346614004212 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1346614004213 NAD(P) binding site [chemical binding]; other site 1346614004214 active site 1346614004215 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614004216 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614004217 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1346614004218 dimerization interface [polypeptide binding]; other site 1346614004219 substrate binding pocket [chemical binding]; other site 1346614004220 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1346614004221 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1346614004222 active site 1346614004223 HIGH motif; other site 1346614004224 dimer interface [polypeptide binding]; other site 1346614004225 KMSKS motif; other site 1346614004226 D-galactonate transporter; Region: 2A0114; TIGR00893 1346614004227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614004228 putative substrate translocation pore; other site 1346614004229 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1346614004230 DNA-binding site [nucleotide binding]; DNA binding site 1346614004231 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1346614004232 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1346614004233 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1346614004234 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1346614004235 putative NAD(P) binding site [chemical binding]; other site 1346614004236 catalytic Zn binding site [ion binding]; other site 1346614004237 structural Zn binding site [ion binding]; other site 1346614004238 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1346614004239 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1346614004240 Walker A/P-loop; other site 1346614004241 ATP binding site [chemical binding]; other site 1346614004242 Q-loop/lid; other site 1346614004243 ABC transporter signature motif; other site 1346614004244 Walker B; other site 1346614004245 D-loop; other site 1346614004246 H-loop/switch region; other site 1346614004247 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 1346614004248 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1346614004249 substrate binding pocket [chemical binding]; other site 1346614004250 membrane-bound complex binding site; other site 1346614004251 hinge residues; other site 1346614004252 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1346614004253 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614004254 dimer interface [polypeptide binding]; other site 1346614004255 conserved gate region; other site 1346614004256 putative PBP binding loops; other site 1346614004257 ABC-ATPase subunit interface; other site 1346614004258 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1346614004259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614004260 dimer interface [polypeptide binding]; other site 1346614004261 conserved gate region; other site 1346614004262 putative PBP binding loops; other site 1346614004263 ABC-ATPase subunit interface; other site 1346614004264 Viral enhancin protein; Region: Enhancin; pfam03272 1346614004265 Peptidase M60-like family; Region: M60-like; pfam13402 1346614004266 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 1346614004267 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1346614004268 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1346614004269 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1346614004270 HAMP domain; Region: HAMP; pfam00672 1346614004271 dimerization interface [polypeptide binding]; other site 1346614004272 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1346614004273 dimer interface [polypeptide binding]; other site 1346614004274 putative CheW interface [polypeptide binding]; other site 1346614004275 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1346614004276 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1346614004277 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 1346614004278 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1346614004279 active site 1346614004280 dimer interface [polypeptide binding]; other site 1346614004281 non-prolyl cis peptide bond; other site 1346614004282 insertion regions; other site 1346614004283 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1346614004284 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1346614004285 active site 1346614004286 dimer interface [polypeptide binding]; other site 1346614004287 non-prolyl cis peptide bond; other site 1346614004288 insertion regions; other site 1346614004289 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1346614004290 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1346614004291 Walker A motif; other site 1346614004292 ATP binding site [chemical binding]; other site 1346614004293 Walker B motif; other site 1346614004294 arginine finger; other site 1346614004295 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1346614004296 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1346614004297 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1346614004298 substrate binding pocket [chemical binding]; other site 1346614004299 hinge residues; other site 1346614004300 allophanate hydrolase; Provisional; Region: PRK08186 1346614004301 Amidase; Region: Amidase; cl11426 1346614004302 urea carboxylase; Region: urea_carbox; TIGR02712 1346614004303 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1346614004304 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1346614004305 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1346614004306 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1346614004307 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1346614004308 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1346614004309 carboxyltransferase (CT) interaction site; other site 1346614004310 biotinylation site [posttranslational modification]; other site 1346614004311 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1346614004312 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1346614004313 DNA-binding site [nucleotide binding]; DNA binding site 1346614004314 FCD domain; Region: FCD; pfam07729 1346614004315 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1346614004316 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1346614004317 putative ligand binding site [chemical binding]; other site 1346614004318 HEAT repeats; Region: HEAT_2; pfam13646 1346614004319 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1346614004320 TM-ABC transporter signature motif; other site 1346614004321 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1346614004322 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1346614004323 TM-ABC transporter signature motif; other site 1346614004324 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1346614004325 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1346614004326 Walker A/P-loop; other site 1346614004327 ATP binding site [chemical binding]; other site 1346614004328 Q-loop/lid; other site 1346614004329 ABC transporter signature motif; other site 1346614004330 Walker B; other site 1346614004331 D-loop; other site 1346614004332 H-loop/switch region; other site 1346614004333 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1346614004334 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1346614004335 Walker A/P-loop; other site 1346614004336 ATP binding site [chemical binding]; other site 1346614004337 Q-loop/lid; other site 1346614004338 ABC transporter signature motif; other site 1346614004339 Walker B; other site 1346614004340 D-loop; other site 1346614004341 H-loop/switch region; other site 1346614004342 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 1346614004343 Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933 1346614004344 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1346614004345 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 1346614004346 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614004347 Coenzyme A binding pocket [chemical binding]; other site 1346614004348 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1346614004349 hypothetical protein; Provisional; Region: PRK06185 1346614004350 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1346614004351 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1346614004352 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1346614004353 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614004354 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1346614004355 dimerization interface [polypeptide binding]; other site 1346614004356 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 1346614004357 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1346614004358 active site residue [active] 1346614004359 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1346614004360 active site residue [active] 1346614004361 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 1346614004362 nudix motif; other site 1346614004363 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1346614004364 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1346614004365 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1346614004366 NAD(P) binding site [chemical binding]; other site 1346614004367 active site 1346614004368 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1346614004369 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1346614004370 short chain dehydrogenase; Provisional; Region: PRK06180 1346614004371 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1346614004372 NADP binding site [chemical binding]; other site 1346614004373 active site 1346614004374 steroid binding site; other site 1346614004375 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1346614004376 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1346614004377 DNA-binding site [nucleotide binding]; DNA binding site 1346614004378 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1346614004379 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614004380 homodimer interface [polypeptide binding]; other site 1346614004381 catalytic residue [active] 1346614004382 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1346614004383 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1346614004384 putative C-terminal domain interface [polypeptide binding]; other site 1346614004385 putative GSH binding site (G-site) [chemical binding]; other site 1346614004386 putative dimer interface [polypeptide binding]; other site 1346614004387 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1346614004388 N-terminal domain interface [polypeptide binding]; other site 1346614004389 dimer interface [polypeptide binding]; other site 1346614004390 substrate binding pocket (H-site) [chemical binding]; other site 1346614004391 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1346614004392 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1346614004393 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1346614004394 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1346614004395 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1346614004396 active site 1346614004397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 1346614004398 Isochorismatase family; Region: Isochorismatase; pfam00857 1346614004399 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1346614004400 catalytic triad [active] 1346614004401 dimer interface [polypeptide binding]; other site 1346614004402 conserved cis-peptide bond; other site 1346614004403 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614004404 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614004405 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1346614004406 dimerization interface [polypeptide binding]; other site 1346614004407 TolA protein; Region: tolA_full; TIGR02794 1346614004408 TolA C-terminal; Region: TolA; pfam06519 1346614004409 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1346614004410 active site 1346614004411 8-oxo-dGMP binding site [chemical binding]; other site 1346614004412 nudix motif; other site 1346614004413 metal binding site [ion binding]; metal-binding site 1346614004414 Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509 1346614004415 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1346614004416 putative di-iron ligands [ion binding]; other site 1346614004417 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1346614004418 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1346614004419 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1346614004420 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1346614004421 Walker A/P-loop; other site 1346614004422 ATP binding site [chemical binding]; other site 1346614004423 Q-loop/lid; other site 1346614004424 ABC transporter signature motif; other site 1346614004425 Walker B; other site 1346614004426 D-loop; other site 1346614004427 H-loop/switch region; other site 1346614004428 CBS domain; Region: CBS; pfam00571 1346614004429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614004430 putative PBP binding loops; other site 1346614004431 dimer interface [polypeptide binding]; other site 1346614004432 ABC-ATPase subunit interface; other site 1346614004433 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1346614004434 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1346614004435 EamA-like transporter family; Region: EamA; pfam00892 1346614004436 EamA-like transporter family; Region: EamA; pfam00892 1346614004437 Predicted transcriptional regulator [Transcription]; Region: COG2345 1346614004438 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614004439 putative substrate translocation pore; other site 1346614004440 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1346614004441 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1346614004442 non-specific DNA binding site [nucleotide binding]; other site 1346614004443 salt bridge; other site 1346614004444 sequence-specific DNA binding site [nucleotide binding]; other site 1346614004445 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1346614004446 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614004447 Coenzyme A binding pocket [chemical binding]; other site 1346614004448 Predicted secreted acid phosphatase [General function prediction only]; Region: COG2503 1346614004449 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614004450 Coenzyme A binding pocket [chemical binding]; other site 1346614004451 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1346614004452 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1346614004453 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1346614004454 trimer interface [polypeptide binding]; other site 1346614004455 eyelet of channel; other site 1346614004456 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1346614004457 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1346614004458 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 1346614004459 DEAD_2; Region: DEAD_2; pfam06733 1346614004460 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1346614004461 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1346614004462 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1346614004463 putative DNA binding site [nucleotide binding]; other site 1346614004464 putative Zn2+ binding site [ion binding]; other site 1346614004465 AsnC family; Region: AsnC_trans_reg; pfam01037 1346614004466 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1346614004467 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1346614004468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614004469 putative substrate translocation pore; other site 1346614004470 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614004471 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614004472 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 1346614004473 putative effector binding pocket; other site 1346614004474 putative dimerization interface [polypeptide binding]; other site 1346614004475 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1346614004476 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1346614004477 salt bridge; other site 1346614004478 non-specific DNA binding site [nucleotide binding]; other site 1346614004479 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1346614004480 sequence-specific DNA binding site [nucleotide binding]; other site 1346614004481 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614004482 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 1346614004483 glycosyl transferase family protein; Provisional; Region: PRK08136 1346614004484 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1346614004485 Peptidase M3-like family, a zincin metallopeptidase, includes M3 and M32 families; Region: M3_like; cd06258 1346614004486 active site 1346614004487 Zn binding site [ion binding]; other site 1346614004488 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 1346614004489 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1346614004490 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 1346614004491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614004492 S-adenosylmethionine binding site [chemical binding]; other site 1346614004493 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1346614004494 PAS domain; Region: PAS_9; pfam13426 1346614004495 putative active site [active] 1346614004496 heme pocket [chemical binding]; other site 1346614004497 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1346614004498 PAS domain; Region: PAS_9; pfam13426 1346614004499 putative active site [active] 1346614004500 heme pocket [chemical binding]; other site 1346614004501 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1346614004502 dimer interface [polypeptide binding]; other site 1346614004503 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1346614004504 putative CheW interface [polypeptide binding]; other site 1346614004505 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1346614004506 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1346614004507 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 1346614004508 PapC N-terminal domain; Region: PapC_N; pfam13954 1346614004509 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1346614004510 PapC C-terminal domain; Region: PapC_C; pfam13953 1346614004511 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 1346614004512 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1346614004513 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1346614004514 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1346614004515 Fimbrial protein; Region: Fimbrial; cl01416 1346614004516 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1346614004517 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1346614004518 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614004519 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1346614004520 Coenzyme A binding pocket [chemical binding]; other site 1346614004521 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1346614004522 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1346614004523 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1346614004524 putative mechanosensitive channel protein; Provisional; Region: PRK11465 1346614004525 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1346614004526 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 1346614004527 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1346614004528 Walker A/P-loop; other site 1346614004529 ATP binding site [chemical binding]; other site 1346614004530 Q-loop/lid; other site 1346614004531 ABC transporter signature motif; other site 1346614004532 Walker B; other site 1346614004533 D-loop; other site 1346614004534 H-loop/switch region; other site 1346614004535 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1346614004536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614004537 dimer interface [polypeptide binding]; other site 1346614004538 conserved gate region; other site 1346614004539 putative PBP binding loops; other site 1346614004540 ABC-ATPase subunit interface; other site 1346614004541 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 1346614004542 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1346614004543 substrate binding pocket [chemical binding]; other site 1346614004544 membrane-bound complex binding site; other site 1346614004545 hinge residues; other site 1346614004546 hypothetical protein; Provisional; Region: PRK11019 1346614004547 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1346614004548 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1346614004549 dimerization interface [polypeptide binding]; other site 1346614004550 DPS ferroxidase diiron center [ion binding]; other site 1346614004551 ion pore; other site 1346614004552 AAA domain; Region: AAA_17; pfam13207 1346614004553 Domain of unknown function (DUF386); Region: DUF386; cl01047 1346614004554 threonine and homoserine efflux system; Provisional; Region: PRK10532 1346614004555 EamA-like transporter family; Region: EamA; pfam00892 1346614004556 outer membrane protein X; Provisional; Region: ompX; PRK09408 1346614004557 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1346614004558 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_7; cd07585 1346614004559 putative active site [active] 1346614004560 catalytic triad [active] 1346614004561 putative dimer interface [polypeptide binding]; other site 1346614004562 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1346614004563 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614004564 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1346614004565 dimerization interface [polypeptide binding]; other site 1346614004566 substrate binding pocket [chemical binding]; other site 1346614004567 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1346614004568 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1346614004569 putative transporter; Provisional; Region: PRK09821 1346614004570 GntP family permease; Region: GntP_permease; pfam02447 1346614004571 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 1346614004572 putative aldolase; Validated; Region: PRK08130 1346614004573 intersubunit interface [polypeptide binding]; other site 1346614004574 active site 1346614004575 Zn2+ binding site [ion binding]; other site 1346614004576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1346614004577 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1346614004578 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1346614004579 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1346614004580 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1346614004581 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1346614004582 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1346614004583 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1346614004584 Moco binding site; other site 1346614004585 metal coordination site [ion binding]; other site 1346614004586 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 1346614004587 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1346614004588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614004589 active site 1346614004590 phosphorylation site [posttranslational modification] 1346614004591 intermolecular recognition site; other site 1346614004592 dimerization interface [polypeptide binding]; other site 1346614004593 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1346614004594 DNA binding site [nucleotide binding] 1346614004595 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1346614004596 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1346614004597 dimerization interface [polypeptide binding]; other site 1346614004598 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1346614004599 dimer interface [polypeptide binding]; other site 1346614004600 phosphorylation site [posttranslational modification] 1346614004601 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614004602 ATP binding site [chemical binding]; other site 1346614004603 Mg2+ binding site [ion binding]; other site 1346614004604 G-X-G motif; other site 1346614004605 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1346614004606 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1346614004607 DNA binding site [nucleotide binding] 1346614004608 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1346614004609 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1346614004610 DNA binding residues [nucleotide binding] 1346614004611 putative fimbrial protein TcfA; Provisional; Region: PRK15308 1346614004612 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1346614004613 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1346614004614 putative fimbrial protein TcfA; Provisional; Region: PRK15308 1346614004615 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1346614004616 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1346614004617 dimerization interface [polypeptide binding]; other site 1346614004618 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1346614004619 dimer interface [polypeptide binding]; other site 1346614004620 phosphorylation site [posttranslational modification] 1346614004621 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614004622 ATP binding site [chemical binding]; other site 1346614004623 Mg2+ binding site [ion binding]; other site 1346614004624 G-X-G motif; other site 1346614004625 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1346614004626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614004627 active site 1346614004628 phosphorylation site [posttranslational modification] 1346614004629 intermolecular recognition site; other site 1346614004630 dimerization interface [polypeptide binding]; other site 1346614004631 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1346614004632 DNA binding site [nucleotide binding] 1346614004633 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 1346614004634 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1346614004635 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1346614004636 Moco binding site; other site 1346614004637 metal coordination site [ion binding]; other site 1346614004638 Protein of unknown function, DUF417; Region: DUF417; cl01162 1346614004639 choline transport protein BetT; Provisional; Region: PRK09928 1346614004640 transcriptional regulator BetI; Validated; Region: PRK00767 1346614004641 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1346614004642 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1346614004643 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 1346614004644 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 1346614004645 tetrameric interface [polypeptide binding]; other site 1346614004646 NAD binding site [chemical binding]; other site 1346614004647 catalytic residues [active] 1346614004648 choline dehydrogenase; Validated; Region: PRK02106 1346614004649 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1346614004650 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1346614004651 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1346614004652 active site 1346614004653 FMN binding site [chemical binding]; other site 1346614004654 substrate binding site [chemical binding]; other site 1346614004655 3Fe-4S cluster binding site [ion binding]; other site 1346614004656 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 1346614004657 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1346614004658 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1346614004659 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1346614004660 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1346614004661 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1346614004662 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1346614004663 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1346614004664 PapC N-terminal domain; Region: PapC_N; pfam13954 1346614004665 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1346614004666 PapC C-terminal domain; Region: PapC_C; pfam13953 1346614004667 Fimbrial protein; Region: Fimbrial; pfam00419 1346614004668 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1346614004669 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614004670 malate:quinone oxidoreductase; Validated; Region: PRK05257 1346614004671 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1346614004672 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1346614004673 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614004674 Coenzyme A binding pocket [chemical binding]; other site 1346614004675 alkaline phosphatase; Provisional; Region: PRK10518 1346614004676 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1346614004677 dimer interface [polypeptide binding]; other site 1346614004678 active site 1346614004679 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1346614004680 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1346614004681 C-terminal domain interface [polypeptide binding]; other site 1346614004682 GSH binding site (G-site) [chemical binding]; other site 1346614004683 dimer interface [polypeptide binding]; other site 1346614004684 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 1346614004685 dimer interface [polypeptide binding]; other site 1346614004686 N-terminal domain interface [polypeptide binding]; other site 1346614004687 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1346614004688 putative DNA binding site [nucleotide binding]; other site 1346614004689 dimerization interface [polypeptide binding]; other site 1346614004690 putative Zn2+ binding site [ion binding]; other site 1346614004691 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1346614004692 Cytochrome P450; Region: p450; cl12078 1346614004693 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1346614004694 AAA domain; Region: AAA_33; pfam13671 1346614004695 AAA domain; Region: AAA_17; pfam13207 1346614004696 cyanate hydratase; Validated; Region: PRK02866 1346614004697 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 1346614004698 oligomer interface [polypeptide binding]; other site 1346614004699 active site 1346614004700 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1346614004701 active site clefts [active] 1346614004702 zinc binding site [ion binding]; other site 1346614004703 dimer interface [polypeptide binding]; other site 1346614004704 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1346614004705 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614004706 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 1346614004707 dimerization interface [polypeptide binding]; other site 1346614004708 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1346614004709 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1346614004710 ATP binding site [chemical binding]; other site 1346614004711 substrate interface [chemical binding]; other site 1346614004712 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 1346614004713 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1346614004714 dimer interface [polypeptide binding]; other site 1346614004715 putative functional site; other site 1346614004716 putative MPT binding site; other site 1346614004717 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 1346614004718 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 1346614004719 catalytic nucleophile [active] 1346614004720 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1346614004721 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1346614004722 Walker A/P-loop; other site 1346614004723 ATP binding site [chemical binding]; other site 1346614004724 Q-loop/lid; other site 1346614004725 ABC transporter signature motif; other site 1346614004726 Walker B; other site 1346614004727 D-loop; other site 1346614004728 H-loop/switch region; other site 1346614004729 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1346614004730 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1346614004731 Walker A/P-loop; other site 1346614004732 ATP binding site [chemical binding]; other site 1346614004733 Q-loop/lid; other site 1346614004734 ABC transporter signature motif; other site 1346614004735 Walker B; other site 1346614004736 D-loop; other site 1346614004737 H-loop/switch region; other site 1346614004738 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1346614004739 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 1346614004740 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 1346614004741 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 1346614004742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614004743 dimer interface [polypeptide binding]; other site 1346614004744 conserved gate region; other site 1346614004745 putative PBP binding loops; other site 1346614004746 ABC-ATPase subunit interface; other site 1346614004747 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 1346614004748 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1346614004749 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614004750 dimer interface [polypeptide binding]; other site 1346614004751 conserved gate region; other site 1346614004752 putative PBP binding loops; other site 1346614004753 ABC-ATPase subunit interface; other site 1346614004754 S-formylglutathione hydrolase; Region: PLN02442 1346614004755 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1346614004756 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1346614004757 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1346614004758 substrate binding site [chemical binding]; other site 1346614004759 catalytic Zn binding site [ion binding]; other site 1346614004760 NAD binding site [chemical binding]; other site 1346614004761 structural Zn binding site [ion binding]; other site 1346614004762 dimer interface [polypeptide binding]; other site 1346614004763 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614004764 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614004765 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1346614004766 putative dimerization interface [polypeptide binding]; other site 1346614004767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614004768 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1346614004769 putative substrate translocation pore; other site 1346614004770 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1346614004771 active site 1346614004772 Predicted membrane protein [Function unknown]; Region: COG2311 1346614004773 hypothetical protein; Provisional; Region: PRK10835 1346614004774 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 1346614004775 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1346614004776 DNA binding site [nucleotide binding] 1346614004777 domain linker motif; other site 1346614004778 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1346614004779 dimerization interface (closed form) [polypeptide binding]; other site 1346614004780 ligand binding site [chemical binding]; other site 1346614004781 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 1346614004782 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 1346614004783 ligand binding site [chemical binding]; other site 1346614004784 calcium binding site [ion binding]; other site 1346614004785 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1346614004786 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 1346614004787 Walker A/P-loop; other site 1346614004788 ATP binding site [chemical binding]; other site 1346614004789 Q-loop/lid; other site 1346614004790 ABC transporter signature motif; other site 1346614004791 Walker B; other site 1346614004792 D-loop; other site 1346614004793 H-loop/switch region; other site 1346614004794 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1346614004795 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1346614004796 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1346614004797 TM-ABC transporter signature motif; other site 1346614004798 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1346614004799 putative active site [active] 1346614004800 malate dehydrogenase; Provisional; Region: PRK13529 1346614004801 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1346614004802 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1346614004803 NAD(P) binding site [chemical binding]; other site 1346614004804 cytidine deaminase; Provisional; Region: PRK09027 1346614004805 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1346614004806 active site 1346614004807 catalytic motif [active] 1346614004808 Zn binding site [ion binding]; other site 1346614004809 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1346614004810 active site 1346614004811 catalytic motif [active] 1346614004812 Zn binding site [ion binding]; other site 1346614004813 hypothetical protein; Provisional; Region: PRK10711 1346614004814 hypothetical protein; Provisional; Region: PRK01821 1346614004815 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614004816 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1346614004817 putative substrate translocation pore; other site 1346614004818 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1346614004819 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1346614004820 active site 1346614004821 HIGH motif; other site 1346614004822 KMSKS motif; other site 1346614004823 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1346614004824 tRNA binding surface [nucleotide binding]; other site 1346614004825 anticodon binding site; other site 1346614004826 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1346614004827 dimer interface [polypeptide binding]; other site 1346614004828 putative tRNA-binding site [nucleotide binding]; other site 1346614004829 antiporter inner membrane protein; Provisional; Region: PRK11670 1346614004830 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1346614004831 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1346614004832 active site 1346614004833 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1346614004834 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1346614004835 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1346614004836 ATP-binding site [chemical binding]; other site 1346614004837 Sugar specificity; other site 1346614004838 Pyrimidine base specificity; other site 1346614004839 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1346614004840 trimer interface [polypeptide binding]; other site 1346614004841 active site 1346614004842 putative assembly protein; Provisional; Region: PRK10833 1346614004843 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1346614004844 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 1346614004845 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1346614004846 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1346614004847 FOG: CBS domain [General function prediction only]; Region: COG0517 1346614004848 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1346614004849 Transporter associated domain; Region: CorC_HlyC; smart01091 1346614004850 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1346614004851 tetramer interface; other site 1346614004852 active site 1346614004853 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1346614004854 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1346614004855 active site 1346614004856 tetramer interface; other site 1346614004857 polysaccharide export protein Wza; Provisional; Region: PRK15078 1346614004858 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1346614004859 SLBB domain; Region: SLBB; pfam10531 1346614004860 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1346614004861 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1346614004862 active site 1346614004863 tyrosine kinase; Provisional; Region: PRK11519 1346614004864 Chain length determinant protein; Region: Wzz; pfam02706 1346614004865 Chain length determinant protein; Region: Wzz; cl15801 1346614004866 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1346614004867 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1346614004868 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1346614004869 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1346614004870 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1346614004871 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1346614004872 O-Antigen ligase; Region: Wzy_C; pfam04932 1346614004873 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1346614004874 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1346614004875 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1346614004876 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1346614004877 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1346614004878 NADP-binding site; other site 1346614004879 homotetramer interface [polypeptide binding]; other site 1346614004880 substrate binding site [chemical binding]; other site 1346614004881 homodimer interface [polypeptide binding]; other site 1346614004882 active site 1346614004883 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1346614004884 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1346614004885 NAD(P) binding site [chemical binding]; other site 1346614004886 active site 1346614004887 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1346614004888 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 1346614004889 putative ADP-binding pocket [chemical binding]; other site 1346614004890 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 1346614004891 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1346614004892 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1346614004893 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 1346614004894 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1346614004895 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 1346614004896 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 1346614004897 Walker A/P-loop; other site 1346614004898 ATP binding site [chemical binding]; other site 1346614004899 Q-loop/lid; other site 1346614004900 ABC transporter signature motif; other site 1346614004901 Walker B; other site 1346614004902 D-loop; other site 1346614004903 H-loop/switch region; other site 1346614004904 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1346614004905 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1346614004906 HlyD family secretion protein; Region: HlyD_3; pfam13437 1346614004907 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1346614004908 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1346614004909 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1346614004910 Substrate binding site; other site 1346614004911 Cupin domain; Region: Cupin_2; cl17218 1346614004912 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1346614004913 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1346614004914 NAD binding site [chemical binding]; other site 1346614004915 homodimer interface [polypeptide binding]; other site 1346614004916 active site 1346614004917 substrate binding site [chemical binding]; other site 1346614004918 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1346614004919 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1346614004920 Substrate binding site; other site 1346614004921 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1346614004922 phosphomannomutase CpsG; Provisional; Region: PRK15414 1346614004923 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1346614004924 active site 1346614004925 substrate binding site [chemical binding]; other site 1346614004926 metal binding site [ion binding]; metal-binding site 1346614004927 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1346614004928 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1346614004929 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1346614004930 Walker A/P-loop; other site 1346614004931 ATP binding site [chemical binding]; other site 1346614004932 Q-loop/lid; other site 1346614004933 ABC transporter signature motif; other site 1346614004934 Walker B; other site 1346614004935 D-loop; other site 1346614004936 H-loop/switch region; other site 1346614004937 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 1346614004938 putative carbohydrate binding site [chemical binding]; other site 1346614004939 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1346614004940 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614004941 S-adenosylmethionine binding site [chemical binding]; other site 1346614004942 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1346614004943 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1346614004944 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1346614004945 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1346614004946 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1346614004947 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1346614004948 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1346614004949 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1346614004950 NADP-binding site; other site 1346614004951 homotetramer interface [polypeptide binding]; other site 1346614004952 substrate binding site [chemical binding]; other site 1346614004953 homodimer interface [polypeptide binding]; other site 1346614004954 active site 1346614004955 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1346614004956 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1346614004957 NADP-binding site; other site 1346614004958 homotetramer interface [polypeptide binding]; other site 1346614004959 substrate binding site [chemical binding]; other site 1346614004960 homodimer interface [polypeptide binding]; other site 1346614004961 active site 1346614004962 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1346614004963 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1346614004964 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 1346614004965 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1346614004966 putative ADP-binding pocket [chemical binding]; other site 1346614004967 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1346614004968 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1346614004969 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1346614004970 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1346614004971 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1346614004972 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1346614004973 metal binding site [ion binding]; metal-binding site 1346614004974 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1346614004975 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1346614004976 substrate binding site [chemical binding]; other site 1346614004977 glutamase interaction surface [polypeptide binding]; other site 1346614004978 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1346614004979 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1346614004980 catalytic residues [active] 1346614004981 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 1346614004982 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1346614004983 putative active site [active] 1346614004984 oxyanion strand; other site 1346614004985 catalytic triad [active] 1346614004986 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 1346614004987 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1346614004988 active site 1346614004989 motif I; other site 1346614004990 motif II; other site 1346614004991 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1346614004992 putative active site pocket [active] 1346614004993 4-fold oligomerization interface [polypeptide binding]; other site 1346614004994 metal binding residues [ion binding]; metal-binding site 1346614004995 3-fold/trimer interface [polypeptide binding]; other site 1346614004996 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 1346614004997 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1346614004998 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614004999 homodimer interface [polypeptide binding]; other site 1346614005000 catalytic residue [active] 1346614005001 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1346614005002 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1346614005003 NAD binding site [chemical binding]; other site 1346614005004 dimerization interface [polypeptide binding]; other site 1346614005005 product binding site; other site 1346614005006 substrate binding site [chemical binding]; other site 1346614005007 zinc binding site [ion binding]; other site 1346614005008 catalytic residues [active] 1346614005009 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1346614005010 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1346614005011 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1346614005012 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1346614005013 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1346614005014 putative NAD(P) binding site [chemical binding]; other site 1346614005015 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614005016 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614005017 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1346614005018 dimerization interface [polypeptide binding]; other site 1346614005019 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1346614005020 agmatinase; Region: agmatinase; TIGR01230 1346614005021 oligomer interface [polypeptide binding]; other site 1346614005022 putative active site [active] 1346614005023 Mn binding site [ion binding]; other site 1346614005024 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 1346614005025 Na binding site [ion binding]; other site 1346614005026 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1346614005027 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1346614005028 oligomer interface [polypeptide binding]; other site 1346614005029 metal binding site [ion binding]; metal-binding site 1346614005030 metal binding site [ion binding]; metal-binding site 1346614005031 putative Cl binding site [ion binding]; other site 1346614005032 basic sphincter; other site 1346614005033 hydrophobic gate; other site 1346614005034 periplasmic entrance; other site 1346614005035 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614005036 Coenzyme A binding pocket [chemical binding]; other site 1346614005037 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1346614005038 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1346614005039 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1346614005040 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1346614005041 putative C-terminal domain interface [polypeptide binding]; other site 1346614005042 putative GSH binding site (G-site) [chemical binding]; other site 1346614005043 putative dimer interface [polypeptide binding]; other site 1346614005044 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1346614005045 putative N-terminal domain interface [polypeptide binding]; other site 1346614005046 putative dimer interface [polypeptide binding]; other site 1346614005047 putative substrate binding pocket (H-site) [chemical binding]; other site 1346614005048 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1346614005049 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1346614005050 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1346614005051 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1346614005052 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1346614005053 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 1346614005054 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1346614005055 homodimer interface [polypeptide binding]; other site 1346614005056 substrate-cofactor binding pocket; other site 1346614005057 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614005058 catalytic residue [active] 1346614005059 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1346614005060 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1346614005061 dimer interface [polypeptide binding]; other site 1346614005062 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614005063 catalytic residue [active] 1346614005064 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1346614005065 FOG: CBS domain [General function prediction only]; Region: COG0517 1346614005066 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1346614005067 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1346614005068 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1346614005069 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1346614005070 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1346614005071 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1346614005072 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1346614005073 serine transporter; Region: stp; TIGR00814 1346614005074 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 1346614005075 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1346614005076 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1346614005077 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1346614005078 intersubunit interface [polypeptide binding]; other site 1346614005079 active site 1346614005080 catalytic residue [active] 1346614005081 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 1346614005082 active site 1346614005083 catalytic residues [active] 1346614005084 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1346614005085 active site 1346614005086 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 1346614005087 active site 1346614005088 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 1346614005089 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 1346614005090 secondary substrate binding site; other site 1346614005091 primary substrate binding site; other site 1346614005092 inhibition loop; other site 1346614005093 dimerization interface [polypeptide binding]; other site 1346614005094 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1346614005095 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1346614005096 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1346614005097 catalytic residue [active] 1346614005098 putative transporter; Provisional; Region: PRK04972 1346614005099 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1346614005100 TrkA-C domain; Region: TrkA_C; pfam02080 1346614005101 TrkA-C domain; Region: TrkA_C; pfam02080 1346614005102 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1346614005103 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 1346614005104 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 1346614005105 GSH binding site [chemical binding]; other site 1346614005106 catalytic residues [active] 1346614005107 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 1346614005108 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1346614005109 RimK-like ATP-grasp domain; Region: RimK; pfam08443 1346614005110 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1346614005111 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1346614005112 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1346614005113 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1346614005114 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1346614005115 Walker A/P-loop; other site 1346614005116 ATP binding site [chemical binding]; other site 1346614005117 Q-loop/lid; other site 1346614005118 ABC transporter signature motif; other site 1346614005119 Walker B; other site 1346614005120 D-loop; other site 1346614005121 H-loop/switch region; other site 1346614005122 TOBE domain; Region: TOBE_2; pfam08402 1346614005123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614005124 dimer interface [polypeptide binding]; other site 1346614005125 conserved gate region; other site 1346614005126 putative PBP binding loops; other site 1346614005127 ABC-ATPase subunit interface; other site 1346614005128 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1346614005129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614005130 dimer interface [polypeptide binding]; other site 1346614005131 conserved gate region; other site 1346614005132 putative PBP binding loops; other site 1346614005133 ABC-ATPase subunit interface; other site 1346614005134 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 1346614005135 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 1346614005136 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614005137 S-adenosylmethionine binding site [chemical binding]; other site 1346614005138 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1346614005139 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1346614005140 substrate binding pocket [chemical binding]; other site 1346614005141 membrane-bound complex binding site; other site 1346614005142 hinge residues; other site 1346614005143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614005144 dimer interface [polypeptide binding]; other site 1346614005145 conserved gate region; other site 1346614005146 putative PBP binding loops; other site 1346614005147 ABC-ATPase subunit interface; other site 1346614005148 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1346614005149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614005150 dimer interface [polypeptide binding]; other site 1346614005151 conserved gate region; other site 1346614005152 putative PBP binding loops; other site 1346614005153 ABC-ATPase subunit interface; other site 1346614005154 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1346614005155 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1346614005156 substrate binding pocket [chemical binding]; other site 1346614005157 membrane-bound complex binding site; other site 1346614005158 hinge residues; other site 1346614005159 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 1346614005160 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1346614005161 Walker A/P-loop; other site 1346614005162 ATP binding site [chemical binding]; other site 1346614005163 Q-loop/lid; other site 1346614005164 ABC transporter signature motif; other site 1346614005165 Walker B; other site 1346614005166 D-loop; other site 1346614005167 H-loop/switch region; other site 1346614005168 putative lipoprotein; Provisional; Region: PRK10533 1346614005169 hypothetical protein; Provisional; Region: PRK02877 1346614005170 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 1346614005171 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1346614005172 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1346614005173 amidase catalytic site [active] 1346614005174 Zn binding residues [ion binding]; other site 1346614005175 substrate binding site [chemical binding]; other site 1346614005176 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1346614005177 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1346614005178 NAD(P) binding site [chemical binding]; other site 1346614005179 active site 1346614005180 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1346614005181 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 1346614005182 putative NAD(P) binding site [chemical binding]; other site 1346614005183 putative active site [active] 1346614005184 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1346614005185 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 1346614005186 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1346614005187 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1346614005188 tetramer interface [polypeptide binding]; other site 1346614005189 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614005190 catalytic residue [active] 1346614005191 pyruvate dehydrogenase; Provisional; Region: PRK09124 1346614005192 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1346614005193 PYR/PP interface [polypeptide binding]; other site 1346614005194 dimer interface [polypeptide binding]; other site 1346614005195 tetramer interface [polypeptide binding]; other site 1346614005196 TPP binding site [chemical binding]; other site 1346614005197 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1346614005198 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1346614005199 TPP-binding site [chemical binding]; other site 1346614005200 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 1346614005201 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1346614005202 FAD binding pocket [chemical binding]; other site 1346614005203 FAD binding motif [chemical binding]; other site 1346614005204 phosphate binding motif [ion binding]; other site 1346614005205 beta-alpha-beta structure motif; other site 1346614005206 NAD binding pocket [chemical binding]; other site 1346614005207 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1346614005208 catalytic loop [active] 1346614005209 iron binding site [ion binding]; other site 1346614005210 hybrid cluster protein; Provisional; Region: PRK05290 1346614005211 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1346614005212 ACS interaction site; other site 1346614005213 CODH interaction site; other site 1346614005214 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1346614005215 ACS interaction site; other site 1346614005216 CODH interaction site; other site 1346614005217 metal cluster binding site [ion binding]; other site 1346614005218 Predicted membrane protein [Function unknown]; Region: COG2431 1346614005219 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1346614005220 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 1346614005221 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1346614005222 putative active site [active] 1346614005223 putative metal-binding site [ion binding]; other site 1346614005224 Protein of unknown function (DUF535); Region: DUF535; pfam04393 1346614005225 macrolide transporter subunit MacA; Provisional; Region: PRK11578 1346614005226 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1346614005227 HlyD family secretion protein; Region: HlyD_3; pfam13437 1346614005228 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1346614005229 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1346614005230 Walker A/P-loop; other site 1346614005231 ATP binding site [chemical binding]; other site 1346614005232 Q-loop/lid; other site 1346614005233 ABC transporter signature motif; other site 1346614005234 Walker B; other site 1346614005235 D-loop; other site 1346614005236 H-loop/switch region; other site 1346614005237 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1346614005238 FtsX-like permease family; Region: FtsX; pfam02687 1346614005239 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1346614005240 DNA-binding site [nucleotide binding]; DNA binding site 1346614005241 RNA-binding motif; other site 1346614005242 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1346614005243 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 1346614005244 Clp amino terminal domain; Region: Clp_N; pfam02861 1346614005245 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1346614005246 Walker A motif; other site 1346614005247 ATP binding site [chemical binding]; other site 1346614005248 Walker B motif; other site 1346614005249 arginine finger; other site 1346614005250 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1346614005251 Walker A motif; other site 1346614005252 ATP binding site [chemical binding]; other site 1346614005253 Walker B motif; other site 1346614005254 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1346614005255 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1346614005256 rRNA binding site [nucleotide binding]; other site 1346614005257 predicted 30S ribosome binding site; other site 1346614005258 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1346614005259 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 1346614005260 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1346614005261 Walker A/P-loop; other site 1346614005262 ATP binding site [chemical binding]; other site 1346614005263 Q-loop/lid; other site 1346614005264 ABC transporter signature motif; other site 1346614005265 Walker B; other site 1346614005266 D-loop; other site 1346614005267 H-loop/switch region; other site 1346614005268 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 1346614005269 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1346614005270 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1346614005271 Walker A/P-loop; other site 1346614005272 ATP binding site [chemical binding]; other site 1346614005273 Q-loop/lid; other site 1346614005274 ABC transporter signature motif; other site 1346614005275 Walker B; other site 1346614005276 D-loop; other site 1346614005277 H-loop/switch region; other site 1346614005278 glutathionine S-transferase; Provisional; Region: PRK10542 1346614005279 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1346614005280 C-terminal domain interface [polypeptide binding]; other site 1346614005281 GSH binding site (G-site) [chemical binding]; other site 1346614005282 dimer interface [polypeptide binding]; other site 1346614005283 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1346614005284 dimer interface [polypeptide binding]; other site 1346614005285 N-terminal domain interface [polypeptide binding]; other site 1346614005286 substrate binding pocket (H-site) [chemical binding]; other site 1346614005287 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614005288 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614005289 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1346614005290 dimerization interface [polypeptide binding]; other site 1346614005291 thioredoxin reductase; Provisional; Region: PRK10262 1346614005292 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1346614005293 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1346614005294 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1346614005295 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1346614005296 putative DNA binding site [nucleotide binding]; other site 1346614005297 putative Zn2+ binding site [ion binding]; other site 1346614005298 AsnC family; Region: AsnC_trans_reg; pfam01037 1346614005299 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1346614005300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614005301 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1346614005302 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1346614005303 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 1346614005304 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1346614005305 recombination factor protein RarA; Reviewed; Region: PRK13342 1346614005306 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1346614005307 Walker A motif; other site 1346614005308 ATP binding site [chemical binding]; other site 1346614005309 Walker B motif; other site 1346614005310 arginine finger; other site 1346614005311 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1346614005312 seryl-tRNA synthetase; Provisional; Region: PRK05431 1346614005313 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1346614005314 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1346614005315 dimer interface [polypeptide binding]; other site 1346614005316 active site 1346614005317 motif 1; other site 1346614005318 motif 2; other site 1346614005319 motif 3; other site 1346614005320 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1346614005321 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1346614005322 putative [Fe4-S4] binding site [ion binding]; other site 1346614005323 putative molybdopterin cofactor binding site [chemical binding]; other site 1346614005324 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1346614005325 putative molybdopterin cofactor binding site; other site 1346614005326 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 1346614005327 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 1346614005328 putative MFS family transporter protein; Provisional; Region: PRK03633 1346614005329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614005330 putative substrate translocation pore; other site 1346614005331 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 1346614005332 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1346614005333 FeS/SAM binding site; other site 1346614005334 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1346614005335 Pyruvate formate lyase 1; Region: PFL1; cd01678 1346614005336 coenzyme A binding site [chemical binding]; other site 1346614005337 active site 1346614005338 catalytic residues [active] 1346614005339 glycine loop; other site 1346614005340 formate transporter; Provisional; Region: PRK10805 1346614005341 uncharacterized domain; Region: TIGR00702 1346614005342 YcaO-like family; Region: YcaO; pfam02624 1346614005343 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 1346614005344 homodimer interface [polypeptide binding]; other site 1346614005345 active site 1346614005346 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1346614005347 homodimer interface [polypeptide binding]; other site 1346614005348 substrate-cofactor binding pocket; other site 1346614005349 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614005350 catalytic residue [active] 1346614005351 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1346614005352 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1346614005353 hinge; other site 1346614005354 active site 1346614005355 cytidylate kinase; Provisional; Region: cmk; PRK00023 1346614005356 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1346614005357 CMP-binding site; other site 1346614005358 The sites determining sugar specificity; other site 1346614005359 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1346614005360 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1346614005361 RNA binding site [nucleotide binding]; other site 1346614005362 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1346614005363 RNA binding site [nucleotide binding]; other site 1346614005364 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 1346614005365 RNA binding site [nucleotide binding]; other site 1346614005366 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 1346614005367 RNA binding site [nucleotide binding]; other site 1346614005368 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1346614005369 RNA binding site [nucleotide binding]; other site 1346614005370 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1346614005371 IHF dimer interface [polypeptide binding]; other site 1346614005372 IHF - DNA interface [nucleotide binding]; other site 1346614005373 ComEC family competence protein; Provisional; Region: PRK11539 1346614005374 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1346614005375 Competence protein; Region: Competence; pfam03772 1346614005376 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1346614005377 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 1346614005378 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1346614005379 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1346614005380 Walker A/P-loop; other site 1346614005381 ATP binding site [chemical binding]; other site 1346614005382 Q-loop/lid; other site 1346614005383 ABC transporter signature motif; other site 1346614005384 Walker B; other site 1346614005385 D-loop; other site 1346614005386 H-loop/switch region; other site 1346614005387 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 1346614005388 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1346614005389 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1346614005390 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1346614005391 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1346614005392 DNA-binding site [nucleotide binding]; DNA binding site 1346614005393 RNA-binding motif; other site 1346614005394 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1346614005395 DNA-binding site [nucleotide binding]; DNA binding site 1346614005396 RNA-binding motif; other site 1346614005397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1346614005398 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1346614005399 Trm112p-like protein; Region: Trm112p; cl01066 1346614005400 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1346614005401 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1346614005402 Ligand binding site; other site 1346614005403 oligomer interface; other site 1346614005404 hypothetical protein; Provisional; Region: PRK10593 1346614005405 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1346614005406 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1346614005407 putative active site [active] 1346614005408 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1346614005409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614005410 S-adenosylmethionine binding site [chemical binding]; other site 1346614005411 condesin subunit F; Provisional; Region: PRK05260 1346614005412 condesin subunit E; Provisional; Region: PRK05256 1346614005413 cell division protein MukB; Provisional; Region: mukB; PRK04863 1346614005414 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1346614005415 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1346614005416 murein L,D-transpeptidase; Provisional; Region: PRK10594 1346614005417 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1346614005418 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1346614005419 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1346614005420 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 1346614005421 Peptidase M15; Region: Peptidase_M15_3; cl01194 1346614005422 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1346614005423 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1346614005424 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1346614005425 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614005426 homodimer interface [polypeptide binding]; other site 1346614005427 catalytic residue [active] 1346614005428 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1346614005429 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1346614005430 trimer interface [polypeptide binding]; other site 1346614005431 eyelet of channel; other site 1346614005432 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1346614005433 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1346614005434 putative dimer interface [polypeptide binding]; other site 1346614005435 putative anticodon binding site; other site 1346614005436 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1346614005437 homodimer interface [polypeptide binding]; other site 1346614005438 motif 1; other site 1346614005439 motif 2; other site 1346614005440 active site 1346614005441 motif 3; other site 1346614005442 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 1346614005443 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 1346614005444 active site 1346614005445 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1346614005446 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1346614005447 metal binding site [ion binding]; metal-binding site 1346614005448 active site 1346614005449 I-site; other site 1346614005450 aminopeptidase N; Provisional; Region: pepN; PRK14015 1346614005451 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1346614005452 active site 1346614005453 Zn binding site [ion binding]; other site 1346614005454 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 1346614005455 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1346614005456 Walker A/P-loop; other site 1346614005457 ATP binding site [chemical binding]; other site 1346614005458 Q-loop/lid; other site 1346614005459 ABC transporter signature motif; other site 1346614005460 Walker B; other site 1346614005461 D-loop; other site 1346614005462 H-loop/switch region; other site 1346614005463 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1346614005464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614005465 dimer interface [polypeptide binding]; other site 1346614005466 conserved gate region; other site 1346614005467 putative PBP binding loops; other site 1346614005468 ABC-ATPase subunit interface; other site 1346614005469 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1346614005470 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1346614005471 active site 1346614005472 dimer interface [polypeptide binding]; other site 1346614005473 non-prolyl cis peptide bond; other site 1346614005474 insertion regions; other site 1346614005475 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1346614005476 substrate binding pocket [chemical binding]; other site 1346614005477 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1346614005478 membrane-bound complex binding site; other site 1346614005479 hinge residues; other site 1346614005480 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 1346614005481 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1346614005482 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1346614005483 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1346614005484 quinone interaction residues [chemical binding]; other site 1346614005485 active site 1346614005486 catalytic residues [active] 1346614005487 FMN binding site [chemical binding]; other site 1346614005488 substrate binding site [chemical binding]; other site 1346614005489 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 1346614005490 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1346614005491 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1346614005492 MOSC domain; Region: MOSC; pfam03473 1346614005493 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1346614005494 catalytic loop [active] 1346614005495 iron binding site [ion binding]; other site 1346614005496 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1346614005497 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1346614005498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614005499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614005500 S-adenosylmethionine binding site [chemical binding]; other site 1346614005501 ABC transporter ATPase component; Reviewed; Region: PRK11147 1346614005502 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1346614005503 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1346614005504 Walker A/P-loop; other site 1346614005505 Walker A/P-loop; other site 1346614005506 ATP binding site [chemical binding]; other site 1346614005507 ATP binding site [chemical binding]; other site 1346614005508 Q-loop/lid; other site 1346614005509 Q-loop/lid; other site 1346614005510 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1346614005511 ABC transporter signature motif; other site 1346614005512 Walker B; other site 1346614005513 D-loop; other site 1346614005514 ABC transporter; Region: ABC_tran_2; pfam12848 1346614005515 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1346614005516 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 1346614005517 Paraquat-inducible protein A; Region: PqiA; pfam04403 1346614005518 Paraquat-inducible protein A; Region: PqiA; pfam04403 1346614005519 paraquat-inducible protein B; Provisional; Region: PRK10807 1346614005520 mce related protein; Region: MCE; pfam02470 1346614005521 mce related protein; Region: MCE; pfam02470 1346614005522 mce related protein; Region: MCE; pfam02470 1346614005523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 1346614005524 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1346614005525 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 1346614005526 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1346614005527 dimer interface [polypeptide binding]; other site 1346614005528 active site 1346614005529 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1346614005530 active site 2 [active] 1346614005531 dimer interface [polypeptide binding]; other site 1346614005532 active site 1 [active] 1346614005533 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 1346614005534 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1346614005535 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 1346614005536 outer membrane protein A; Reviewed; Region: PRK10808 1346614005537 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 1346614005538 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1346614005539 ligand binding site [chemical binding]; other site 1346614005540 SOS cell division inhibitor; Provisional; Region: PRK10595 1346614005541 TfoX N-terminal domain; Region: TfoX_N; pfam04993 1346614005542 TfoX C-terminal domain; Region: TfoX_C; pfam04994 1346614005543 TIGR01666 family membrane protein; Region: YCCS 1346614005544 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1346614005545 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1346614005546 Predicted membrane protein [Function unknown]; Region: COG3304 1346614005547 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1346614005548 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1346614005549 DNA helicase IV; Provisional; Region: helD; PRK11054 1346614005550 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 1346614005551 Part of AAA domain; Region: AAA_19; pfam13245 1346614005552 Family description; Region: UvrD_C_2; pfam13538 1346614005553 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1346614005554 active site 1346614005555 dimer interfaces [polypeptide binding]; other site 1346614005556 catalytic residues [active] 1346614005557 hypothetical protein; Provisional; Region: PRK03641 1346614005558 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 1346614005559 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1346614005560 heat shock protein HspQ; Provisional; Region: PRK14129 1346614005561 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 1346614005562 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 1346614005563 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1346614005564 putative RNA binding site [nucleotide binding]; other site 1346614005565 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614005566 S-adenosylmethionine binding site [chemical binding]; other site 1346614005567 acylphosphatase; Provisional; Region: PRK14426 1346614005568 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1346614005569 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 1346614005570 YccA-like proteins; Region: YccA_like; cd10433 1346614005571 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1346614005572 BCCT family transporter; Region: BCCT; cl00569 1346614005573 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1346614005574 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1346614005575 Cytochrome c; Region: Cytochrom_C; pfam00034 1346614005576 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1346614005577 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1346614005578 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 1346614005579 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 1346614005580 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1346614005581 active site 1346614005582 substrate binding site [chemical binding]; other site 1346614005583 Mg2+ binding site [ion binding]; other site 1346614005584 Cation transport protein; Region: TrkH; cl17365 1346614005585 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1346614005586 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 1346614005587 LysE type translocator; Region: LysE; cl00565 1346614005588 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 1346614005589 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614005590 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1346614005591 dimerization interface [polypeptide binding]; other site 1346614005592 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1346614005593 non-specific DNA binding site [nucleotide binding]; other site 1346614005594 salt bridge; other site 1346614005595 sequence-specific DNA binding site [nucleotide binding]; other site 1346614005596 2TM domain; Region: 2TM; pfam13239 1346614005597 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1346614005598 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1346614005599 non-specific DNA binding site [nucleotide binding]; other site 1346614005600 salt bridge; other site 1346614005601 sequence-specific DNA binding site [nucleotide binding]; other site 1346614005602 Cupin domain; Region: Cupin_2; cl17218 1346614005603 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1346614005604 EamA-like transporter family; Region: EamA; pfam00892 1346614005605 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1346614005606 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 1346614005607 pyrimidine utilization protein D; Region: RutD; TIGR03611 1346614005608 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1346614005609 homotrimer interaction site [polypeptide binding]; other site 1346614005610 putative active site [active] 1346614005611 Isochorismatase family; Region: Isochorismatase; pfam00857 1346614005612 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1346614005613 catalytic triad [active] 1346614005614 conserved cis-peptide bond; other site 1346614005615 pyrimidine utilization protein A; Region: RutA; TIGR03612 1346614005616 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1346614005617 active site 1346614005618 dimer interface [polypeptide binding]; other site 1346614005619 non-prolyl cis peptide bond; other site 1346614005620 insertion regions; other site 1346614005621 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 1346614005622 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1346614005623 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1346614005624 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1346614005625 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 1346614005626 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1346614005627 GIY-YIG motif/motif A; other site 1346614005628 active site 1346614005629 catalytic site [active] 1346614005630 putative DNA binding site [nucleotide binding]; other site 1346614005631 metal binding site [ion binding]; metal-binding site 1346614005632 TolA C-terminal; Region: TolA; pfam06519 1346614005633 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1346614005634 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1346614005635 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1346614005636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614005637 putative substrate translocation pore; other site 1346614005638 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1346614005639 enoyl-CoA hydratase; Provisional; Region: PRK08252 1346614005640 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1346614005641 substrate binding site [chemical binding]; other site 1346614005642 oxyanion hole (OAH) forming residues; other site 1346614005643 trimer interface [polypeptide binding]; other site 1346614005644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614005645 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1346614005646 putative substrate translocation pore; other site 1346614005647 5-aminolevulinate synthase; Validated; Region: PRK09064 1346614005648 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1346614005649 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1346614005650 catalytic residue [active] 1346614005651 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1346614005652 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1346614005653 dimer interface [polypeptide binding]; other site 1346614005654 active site 1346614005655 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 1346614005656 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1346614005657 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1346614005658 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1346614005659 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1346614005660 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1346614005661 DNA binding residues [nucleotide binding] 1346614005662 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1346614005663 Ligand Binding Site [chemical binding]; other site 1346614005664 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 1346614005665 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1346614005666 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1346614005667 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1346614005668 dimer interface [polypeptide binding]; other site 1346614005669 NADP binding site [chemical binding]; other site 1346614005670 catalytic residues [active] 1346614005671 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1346614005672 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1346614005673 inhibitor site; inhibition site 1346614005674 active site 1346614005675 dimer interface [polypeptide binding]; other site 1346614005676 catalytic residue [active] 1346614005677 PAS fold; Region: PAS_4; pfam08448 1346614005678 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1346614005679 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614005680 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 1346614005681 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1346614005682 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1346614005683 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1346614005684 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1346614005685 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1346614005686 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 1346614005687 GlpM protein; Region: GlpM; pfam06942 1346614005688 hypothetical protein; Provisional; Region: PRK10613 1346614005689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614005690 intermolecular recognition site; other site 1346614005691 active site 1346614005692 dimerization interface [polypeptide binding]; other site 1346614005693 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1346614005694 DNA binding residues [nucleotide binding] 1346614005695 dimerization interface [polypeptide binding]; other site 1346614005696 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1346614005697 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1346614005698 GIY-YIG motif/motif A; other site 1346614005699 active site 1346614005700 catalytic site [active] 1346614005701 putative DNA binding site [nucleotide binding]; other site 1346614005702 metal binding site [ion binding]; metal-binding site 1346614005703 UvrB/uvrC motif; Region: UVR; pfam02151 1346614005704 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1346614005705 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 1346614005706 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1346614005707 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1346614005708 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1346614005709 putative active site [active] 1346614005710 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1346614005711 active site 1346614005712 P-loop; other site 1346614005713 phosphorylation site [posttranslational modification] 1346614005714 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 1346614005715 methionine cluster; other site 1346614005716 active site 1346614005717 phosphorylation site [posttranslational modification] 1346614005718 metal binding site [ion binding]; metal-binding site 1346614005719 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1346614005720 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1346614005721 NAD binding site [chemical binding]; other site 1346614005722 sugar binding site [chemical binding]; other site 1346614005723 divalent metal binding site [ion binding]; other site 1346614005724 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1346614005725 dimer interface [polypeptide binding]; other site 1346614005726 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1346614005727 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 1346614005728 phosphoethanolamine transferase; Provisional; Region: PRK11560 1346614005729 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1346614005730 Sulfatase; Region: Sulfatase; pfam00884 1346614005731 proline/glycine betaine transporter; Provisional; Region: PRK10642 1346614005732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614005733 putative substrate translocation pore; other site 1346614005734 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 1346614005735 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1346614005736 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1346614005737 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1346614005738 Walker A/P-loop; other site 1346614005739 ATP binding site [chemical binding]; other site 1346614005740 Q-loop/lid; other site 1346614005741 ABC transporter signature motif; other site 1346614005742 Walker B; other site 1346614005743 D-loop; other site 1346614005744 H-loop/switch region; other site 1346614005745 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1346614005746 FtsX-like permease family; Region: FtsX; pfam02687 1346614005747 macrolide transporter subunit MacA; Provisional; Region: PRK11578 1346614005748 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1346614005749 HlyD family secretion protein; Region: HlyD_3; pfam13437 1346614005750 integrase; Provisional; Region: PRK09692 1346614005751 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1346614005752 active site 1346614005753 Int/Topo IB signature motif; other site 1346614005754 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1346614005755 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1346614005756 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1346614005757 ATP binding site [chemical binding]; other site 1346614005758 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1346614005759 nucleotide binding region [chemical binding]; other site 1346614005760 ATP-binding site [chemical binding]; other site 1346614005761 HNH endonuclease; Region: HNH_3; pfam13392 1346614005762 KilA-N domain; Region: KilA-N; pfam04383 1346614005763 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1346614005764 Arc-like DNA binding domain; Region: Arc; pfam03869 1346614005765 Arc-like DNA binding domain; Region: Arc; pfam03869 1346614005766 VRR-NUC domain; Region: VRR_NUC; pfam08774 1346614005767 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1346614005768 active site 1346614005769 substrate binding site [chemical binding]; other site 1346614005770 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 1346614005771 active site 1346614005772 DNA binding site [nucleotide binding] 1346614005773 catalytic site [active] 1346614005774 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 1346614005775 SPFH domain / Band 7 family; Region: Band_7; pfam01145 1346614005776 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1346614005777 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 1346614005778 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 1346614005779 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1346614005780 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1346614005781 non-specific DNA binding site [nucleotide binding]; other site 1346614005782 salt bridge; other site 1346614005783 sequence-specific DNA binding site [nucleotide binding]; other site 1346614005784 Predicted transcriptional regulator [Transcription]; Region: COG2932 1346614005785 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1346614005786 Catalytic site [active] 1346614005787 putative Cro-like protein; Region: PHA00542 1346614005788 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1346614005789 nucleotide binding site [chemical binding]; other site 1346614005790 Virulence-associated protein E; Region: VirE; pfam05272 1346614005791 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 1346614005792 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 1346614005793 Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106 1346614005794 Predicted chitinase [General function prediction only]; Region: COG3179 1346614005795 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 1346614005796 hypothetical protein; Region: PHA01971 1346614005797 Protein of unknown function (DUF2560); Region: DUF2560; cl10280 1346614005798 Terminase small subunit; Region: Terminase_2; pfam03592 1346614005799 Terminase-like family; Region: Terminase_6; pfam03237 1346614005800 Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565 1346614005801 Bacteriophage, scaffolding protein; Region: Phage-scaffold; pfam09306 1346614005802 coat protein; Region: PHA01511 1346614005803 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 1346614005804 P22 tail accessory factor; Region: P22_Tail-4; pfam11650 1346614005805 Phage stabilisation protein; Region: Phage_stabilise; pfam11134 1346614005806 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1346614005807 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1346614005808 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1346614005809 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1346614005810 catalytic residue [active] 1346614005811 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1346614005812 Mnt; Region: mnt; PHA01513 1346614005813 Arc-like DNA binding domain; Region: Arc; pfam03869 1346614005814 Regulatory protein Mnt; Region: Repressor_Mnt; pfam11423 1346614005815 Head binding; Region: Head_binding; pfam09008 1346614005816 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 1346614005817 potassium/proton antiporter; Reviewed; Region: PRK05326 1346614005818 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1346614005819 TrkA-C domain; Region: TrkA_C; pfam02080 1346614005820 Transporter associated domain; Region: CorC_HlyC; smart01091 1346614005821 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1346614005822 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1346614005823 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1346614005824 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 1346614005825 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1346614005826 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1346614005827 Ligand binding site; other site 1346614005828 DXD motif; other site 1346614005829 lipoprotein; Provisional; Region: PRK10175 1346614005830 secY/secA suppressor protein; Provisional; Region: PRK11467 1346614005831 2-isopropylmalate synthase; Validated; Region: PRK03739 1346614005832 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1346614005833 active site 1346614005834 catalytic residues [active] 1346614005835 metal binding site [ion binding]; metal-binding site 1346614005836 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1346614005837 Cupin domain; Region: Cupin_2; cl17218 1346614005838 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1346614005839 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614005840 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1346614005841 dimerization interface [polypeptide binding]; other site 1346614005842 putative DNA binding site [nucleotide binding]; other site 1346614005843 putative Zn2+ binding site [ion binding]; other site 1346614005844 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 1346614005845 Predicted transporter component [General function prediction only]; Region: COG2391 1346614005846 Sulphur transport; Region: Sulf_transp; pfam04143 1346614005847 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1346614005848 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1346614005849 active site 1346614005850 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 1346614005851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614005852 putative substrate translocation pore; other site 1346614005853 POT family; Region: PTR2; cl17359 1346614005854 drug efflux system protein MdtG; Provisional; Region: PRK09874 1346614005855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614005856 putative substrate translocation pore; other site 1346614005857 YCII-related domain; Region: YCII; cl00999 1346614005858 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1346614005859 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1346614005860 putative acyl-acceptor binding pocket; other site 1346614005861 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1346614005862 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1346614005863 active site 1346614005864 FMN binding site [chemical binding]; other site 1346614005865 substrate binding site [chemical binding]; other site 1346614005866 homotetramer interface [polypeptide binding]; other site 1346614005867 catalytic residue [active] 1346614005868 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1346614005869 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1346614005870 active site residue [active] 1346614005871 YceI-like domain; Region: YceI; cl01001 1346614005872 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1346614005873 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 1346614005874 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1346614005875 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1346614005876 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 1346614005877 NADP binding site [chemical binding]; other site 1346614005878 dimer interface [polypeptide binding]; other site 1346614005879 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 1346614005880 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1346614005881 DNA binding residues [nucleotide binding] 1346614005882 dimerization interface [polypeptide binding]; other site 1346614005883 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1346614005884 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 1346614005885 DNA damage-inducible protein I; Provisional; Region: PRK10597 1346614005886 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1346614005887 active site 1346614005888 substrate binding pocket [chemical binding]; other site 1346614005889 dimer interface [polypeptide binding]; other site 1346614005890 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1346614005891 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 1346614005892 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1346614005893 homodimer interface [polypeptide binding]; other site 1346614005894 oligonucleotide binding site [chemical binding]; other site 1346614005895 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 1346614005896 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1346614005897 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1346614005898 RNA binding surface [nucleotide binding]; other site 1346614005899 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1346614005900 active site 1346614005901 Maf-like protein; Provisional; Region: PRK14361 1346614005902 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1346614005903 active site 1346614005904 dimer interface [polypeptide binding]; other site 1346614005905 hypothetical protein; Provisional; Region: PRK11193 1346614005906 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1346614005907 putative phosphate acyltransferase; Provisional; Region: PRK05331 1346614005908 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1346614005909 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1346614005910 dimer interface [polypeptide binding]; other site 1346614005911 active site 1346614005912 CoA binding pocket [chemical binding]; other site 1346614005913 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1346614005914 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1346614005915 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1346614005916 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1346614005917 NAD(P) binding site [chemical binding]; other site 1346614005918 homotetramer interface [polypeptide binding]; other site 1346614005919 homodimer interface [polypeptide binding]; other site 1346614005920 active site 1346614005921 acyl carrier protein; Provisional; Region: acpP; PRK00982 1346614005922 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1346614005923 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1346614005924 dimer interface [polypeptide binding]; other site 1346614005925 active site 1346614005926 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1346614005927 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1346614005928 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614005929 catalytic residue [active] 1346614005930 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 1346614005931 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1346614005932 dimerization interface [polypeptide binding]; other site 1346614005933 thymidylate kinase; Validated; Region: tmk; PRK00698 1346614005934 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1346614005935 TMP-binding site; other site 1346614005936 ATP-binding site [chemical binding]; other site 1346614005937 DNA polymerase III subunit delta'; Validated; Region: PRK07993 1346614005938 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 1346614005939 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1346614005940 active site 1346614005941 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 1346614005942 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1346614005943 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1346614005944 active site turn [active] 1346614005945 phosphorylation site [posttranslational modification] 1346614005946 manganese transport regulator MntR; Provisional; Region: PRK11050 1346614005947 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1346614005948 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1346614005949 manganese transport protein MntH; Reviewed; Region: PRK00701 1346614005950 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1346614005951 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614005952 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614005953 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1346614005954 putative effector binding pocket; other site 1346614005955 dimerization interface [polypeptide binding]; other site 1346614005956 SnoaL-like domain; Region: SnoaL_3; pfam13474 1346614005957 short chain dehydrogenase; Provisional; Region: PRK06500 1346614005958 classical (c) SDRs; Region: SDR_c; cd05233 1346614005959 NAD(P) binding site [chemical binding]; other site 1346614005960 active site 1346614005961 Predicted transcriptional regulators [Transcription]; Region: COG1733 1346614005962 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1346614005963 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1346614005964 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1346614005965 substrate binding pocket [chemical binding]; other site 1346614005966 membrane-bound complex binding site; other site 1346614005967 hinge residues; other site 1346614005968 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1346614005969 nucleotide binding site/active site [active] 1346614005970 HIT family signature motif; other site 1346614005971 catalytic residue [active] 1346614005972 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 1346614005973 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 1346614005974 putative dimer interface [polypeptide binding]; other site 1346614005975 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 1346614005976 thiamine kinase; Region: ycfN_thiK; TIGR02721 1346614005977 active site 1346614005978 substrate binding site [chemical binding]; other site 1346614005979 ATP binding site [chemical binding]; other site 1346614005980 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1346614005981 beta-hexosaminidase; Provisional; Region: PRK05337 1346614005982 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1346614005983 hypothetical protein; Provisional; Region: PRK04940 1346614005984 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1346614005985 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1346614005986 hypothetical protein; Provisional; Region: PRK11280 1346614005987 Predicted transcriptional regulator [Transcription]; Region: COG1959 1346614005988 Transcriptional regulator; Region: Rrf2; pfam02082 1346614005989 Transcriptional regulator; Region: Rrf2; cl17282 1346614005990 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1346614005991 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1346614005992 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1346614005993 HlyD family secretion protein; Region: HlyD_3; pfam13437 1346614005994 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1346614005995 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614005996 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1346614005997 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614005998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614005999 putative substrate translocation pore; other site 1346614006000 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 1346614006001 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1346614006002 putative ligand binding site [chemical binding]; other site 1346614006003 NAD binding site [chemical binding]; other site 1346614006004 dimerization interface [polypeptide binding]; other site 1346614006005 catalytic site [active] 1346614006006 putative hydrolase; Validated; Region: PRK09248 1346614006007 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 1346614006008 active site 1346614006009 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 1346614006010 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 1346614006011 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1346614006012 putative metal binding site [ion binding]; other site 1346614006013 protease 2; Provisional; Region: PRK10115 1346614006014 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1346614006015 exodeoxyribonuclease X; Provisional; Region: PRK07983 1346614006016 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1346614006017 active site 1346614006018 catalytic site [active] 1346614006019 substrate binding site [chemical binding]; other site 1346614006020 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 1346614006021 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1346614006022 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 1346614006023 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1346614006024 Ferritin-like domain; Region: Ferritin; pfam00210 1346614006025 ferroxidase diiron center [ion binding]; other site 1346614006026 CopC domain; Region: CopC; cl01012 1346614006027 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1346614006028 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 1346614006029 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1346614006030 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 1346614006031 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 1346614006032 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1346614006033 active site 1346614006034 substrate binding site [chemical binding]; other site 1346614006035 Phosphotransferase enzyme family; Region: APH; pfam01636 1346614006036 ATP binding site [chemical binding]; other site 1346614006037 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 1346614006038 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 1346614006039 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 1346614006040 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 1346614006041 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 1346614006042 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1346614006043 salt bridge; other site 1346614006044 non-specific DNA binding site [nucleotide binding]; other site 1346614006045 sequence-specific DNA binding site [nucleotide binding]; other site 1346614006046 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 1346614006047 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614006048 active site 1346614006049 phosphorylation site [posttranslational modification] 1346614006050 intermolecular recognition site; other site 1346614006051 dimerization interface [polypeptide binding]; other site 1346614006052 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1346614006053 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614006054 ATP binding site [chemical binding]; other site 1346614006055 Mg2+ binding site [ion binding]; other site 1346614006056 G-X-G motif; other site 1346614006057 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1346614006058 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1346614006059 putative active site; other site 1346614006060 catalytic residue [active] 1346614006061 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1346614006062 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 1346614006063 putative ligand binding site [chemical binding]; other site 1346614006064 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1346614006065 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1346614006066 Walker A/P-loop; other site 1346614006067 ATP binding site [chemical binding]; other site 1346614006068 Q-loop/lid; other site 1346614006069 ABC transporter signature motif; other site 1346614006070 Walker B; other site 1346614006071 D-loop; other site 1346614006072 H-loop/switch region; other site 1346614006073 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1346614006074 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1346614006075 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1346614006076 TM-ABC transporter signature motif; other site 1346614006077 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1346614006078 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 1346614006079 putative ligand binding site [chemical binding]; other site 1346614006080 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1346614006081 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1346614006082 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1346614006083 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1346614006084 DNA-binding site [nucleotide binding]; DNA binding site 1346614006085 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1346614006086 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 1346614006087 DctM-like transporters; Region: DctM; pfam06808 1346614006088 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1346614006089 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1346614006090 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 1346614006091 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 1346614006092 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1346614006093 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1346614006094 DNA binding residues [nucleotide binding] 1346614006095 dimerization interface [polypeptide binding]; other site 1346614006096 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1346614006097 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 1346614006098 putative active site [active] 1346614006099 catalytic triad [active] 1346614006100 putative dimer interface [polypeptide binding]; other site 1346614006101 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; pfam07073 1346614006102 Domain of unknown function (DUF2024); Region: DUF2024; pfam09630 1346614006103 Haem-binding domain; Region: Haem_bd; pfam14376 1346614006104 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 1346614006105 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1346614006106 Ligand Binding Site [chemical binding]; other site 1346614006107 putative kinase; Provisional; Region: PRK09954 1346614006108 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1346614006109 putative DNA binding site [nucleotide binding]; other site 1346614006110 putative Zn2+ binding site [ion binding]; other site 1346614006111 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 1346614006112 substrate binding site [chemical binding]; other site 1346614006113 ATP binding site [chemical binding]; other site 1346614006114 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 1346614006115 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1346614006116 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1346614006117 Nucleoside recognition; Region: Gate; pfam07670 1346614006118 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1346614006119 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1346614006120 dimerization interface [polypeptide binding]; other site 1346614006121 putative DNA binding site [nucleotide binding]; other site 1346614006122 putative Zn2+ binding site [ion binding]; other site 1346614006123 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1346614006124 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1346614006125 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1346614006126 oligomer interface [polypeptide binding]; other site 1346614006127 active site residues [active] 1346614006128 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1346614006129 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1346614006130 Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis; Region: PBP1_allose_binding; cd06320 1346614006131 ligand binding site [chemical binding]; other site 1346614006132 dimerization interface [polypeptide binding]; other site 1346614006133 zinc binding site [ion binding]; other site 1346614006134 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1346614006135 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1346614006136 Walker A/P-loop; other site 1346614006137 ATP binding site [chemical binding]; other site 1346614006138 Q-loop/lid; other site 1346614006139 ABC transporter signature motif; other site 1346614006140 Walker B; other site 1346614006141 D-loop; other site 1346614006142 H-loop/switch region; other site 1346614006143 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1346614006144 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1346614006145 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1346614006146 TM-ABC transporter signature motif; other site 1346614006147 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 1346614006148 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1346614006149 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1346614006150 putative active site [active] 1346614006151 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1346614006152 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1346614006153 substrate binding site [chemical binding]; other site 1346614006154 ATP binding site [chemical binding]; other site 1346614006155 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 1346614006156 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1346614006157 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1346614006158 RibD C-terminal domain; Region: RibD_C; cl17279 1346614006159 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1346614006160 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1346614006161 WYL domain; Region: WYL; pfam13280 1346614006162 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1346614006163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 1346614006164 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 1346614006165 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1346614006166 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 1346614006167 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1346614006168 HTH-like domain; Region: HTH_21; pfam13276 1346614006169 Integrase core domain; Region: rve; pfam00665 1346614006170 Integrase core domain; Region: rve_3; pfam13683 1346614006171 Transposase; Region: HTH_Tnp_1; pfam01527 1346614006172 integrase; Provisional; Region: PRK09692 1346614006173 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1346614006174 active site 1346614006175 Int/Topo IB signature motif; other site 1346614006176 GTP-binding protein YchF; Reviewed; Region: PRK09601 1346614006177 YchF GTPase; Region: YchF; cd01900 1346614006178 G1 box; other site 1346614006179 GTP/Mg2+ binding site [chemical binding]; other site 1346614006180 Switch I region; other site 1346614006181 G2 box; other site 1346614006182 Switch II region; other site 1346614006183 G3 box; other site 1346614006184 G4 box; other site 1346614006185 G5 box; other site 1346614006186 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1346614006187 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1346614006188 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1346614006189 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1346614006190 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1346614006191 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1346614006192 putative active site [active] 1346614006193 catalytic residue [active] 1346614006194 hypothetical protein; Provisional; Region: PRK10692 1346614006195 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1346614006196 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1346614006197 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1346614006198 active site 1346614006199 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1346614006200 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1346614006201 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1346614006202 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 1346614006203 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1346614006204 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1346614006205 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1346614006206 RF-1 domain; Region: RF-1; pfam00472 1346614006207 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1346614006208 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614006209 Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247 1346614006210 hypothetical protein; Provisional; Region: PRK10941 1346614006211 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1346614006212 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1346614006213 binding surface 1346614006214 TPR motif; other site 1346614006215 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1346614006216 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1346614006217 putative transporter; Provisional; Region: PRK11660 1346614006218 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1346614006219 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1346614006220 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1346614006221 hypothetical protein; Provisional; Region: PRK02487 1346614006222 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1346614006223 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1346614006224 metal binding site [ion binding]; metal-binding site 1346614006225 active site 1346614006226 I-site; other site 1346614006227 transcription-repair coupling factor; Provisional; Region: PRK10689 1346614006228 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1346614006229 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1346614006230 ATP binding site [chemical binding]; other site 1346614006231 putative Mg++ binding site [ion binding]; other site 1346614006232 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1346614006233 nucleotide binding region [chemical binding]; other site 1346614006234 ATP-binding site [chemical binding]; other site 1346614006235 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1346614006236 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1346614006237 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1346614006238 tetramer interface [polypeptide binding]; other site 1346614006239 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614006240 catalytic residue [active] 1346614006241 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1346614006242 YheO-like PAS domain; Region: PAS_6; pfam08348 1346614006243 HTH domain; Region: HTH_22; pfam13309 1346614006244 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 1346614006245 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1346614006246 FtsX-like permease family; Region: FtsX; pfam02687 1346614006247 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 1346614006248 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1346614006249 Walker A/P-loop; other site 1346614006250 ATP binding site [chemical binding]; other site 1346614006251 Q-loop/lid; other site 1346614006252 ABC transporter signature motif; other site 1346614006253 Walker B; other site 1346614006254 D-loop; other site 1346614006255 H-loop/switch region; other site 1346614006256 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 1346614006257 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1346614006258 FtsX-like permease family; Region: FtsX; pfam02687 1346614006259 fructokinase; Reviewed; Region: PRK09557 1346614006260 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1346614006261 nucleotide binding site [chemical binding]; other site 1346614006262 NAD-dependent deacetylase; Provisional; Region: PRK00481 1346614006263 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1346614006264 NAD+ binding site [chemical binding]; other site 1346614006265 substrate binding site [chemical binding]; other site 1346614006266 Zn binding site [ion binding]; other site 1346614006267 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1346614006268 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1346614006269 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1346614006270 putative active site [active] 1346614006271 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1346614006272 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1346614006273 NAD(P) binding site [chemical binding]; other site 1346614006274 LDH/MDH dimer interface [polypeptide binding]; other site 1346614006275 substrate binding site [chemical binding]; other site 1346614006276 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1346614006277 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1346614006278 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1346614006279 active site turn [active] 1346614006280 phosphorylation site [posttranslational modification] 1346614006281 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 1346614006282 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1346614006283 metal binding site [ion binding]; metal-binding site 1346614006284 dimer interface [polypeptide binding]; other site 1346614006285 putative dehydrogenase; Provisional; Region: PRK10098 1346614006286 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1346614006287 Cupin domain; Region: Cupin_2; cl17218 1346614006288 sensor protein PhoQ; Provisional; Region: PRK10815 1346614006289 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 1346614006290 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1346614006291 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614006292 ATP binding site [chemical binding]; other site 1346614006293 Mg2+ binding site [ion binding]; other site 1346614006294 G-X-G motif; other site 1346614006295 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 1346614006296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614006297 active site 1346614006298 phosphorylation site [posttranslational modification] 1346614006299 intermolecular recognition site; other site 1346614006300 dimerization interface [polypeptide binding]; other site 1346614006301 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1346614006302 DNA binding site [nucleotide binding] 1346614006303 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1346614006304 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1346614006305 Cytochrome c; Region: Cytochrom_C; pfam00034 1346614006306 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1346614006307 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1346614006308 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1346614006309 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1346614006310 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1346614006311 DNA-binding site [nucleotide binding]; DNA binding site 1346614006312 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1346614006313 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614006314 homodimer interface [polypeptide binding]; other site 1346614006315 catalytic residue [active] 1346614006316 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1346614006317 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614006318 Coenzyme A binding pocket [chemical binding]; other site 1346614006319 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1346614006320 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1346614006321 adenylosuccinate lyase; Provisional; Region: PRK09285 1346614006322 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1346614006323 tetramer interface [polypeptide binding]; other site 1346614006324 active site 1346614006325 putative lysogenization regulator; Reviewed; Region: PRK00218 1346614006326 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1346614006327 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1346614006328 Ligand Binding Site [chemical binding]; other site 1346614006329 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 1346614006330 nudix motif; other site 1346614006331 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1346614006332 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 1346614006333 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 1346614006334 probable active site [active] 1346614006335 isocitrate dehydrogenase; Validated; Region: PRK07362 1346614006336 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1346614006337 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1346614006338 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1346614006339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614006340 putative substrate translocation pore; other site 1346614006341 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1346614006342 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 1346614006343 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1346614006344 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1346614006345 DNA binding site [nucleotide binding] 1346614006346 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 1346614006347 putative ligand binding site [chemical binding]; other site 1346614006348 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1346614006349 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1346614006350 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1346614006351 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1346614006352 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 1346614006353 Protein of unknown function; Region: DUF3658; pfam12395 1346614006354 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1346614006355 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1346614006356 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1346614006357 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1346614006358 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1346614006359 DNA-binding site [nucleotide binding]; DNA binding site 1346614006360 RNA-binding motif; other site 1346614006361 Isochorismatase family; Region: Isochorismatase; pfam00857 1346614006362 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1346614006363 catalytic triad [active] 1346614006364 dimer interface [polypeptide binding]; other site 1346614006365 conserved cis-peptide bond; other site 1346614006366 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1346614006367 Ligand Binding Site [chemical binding]; other site 1346614006368 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1346614006369 classical (c) SDRs; Region: SDR_c; cd05233 1346614006370 NAD(P) binding site [chemical binding]; other site 1346614006371 active site 1346614006372 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1346614006373 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1346614006374 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 1346614006375 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1346614006376 NAD(P) binding site [chemical binding]; other site 1346614006377 catalytic residues [active] 1346614006378 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1346614006379 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1346614006380 non-specific DNA binding site [nucleotide binding]; other site 1346614006381 salt bridge; other site 1346614006382 sequence-specific DNA binding site [nucleotide binding]; other site 1346614006383 Cupin domain; Region: Cupin_2; pfam07883 1346614006384 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1346614006385 catalytic triad [active] 1346614006386 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1346614006387 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1346614006388 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1346614006389 aromatic amino acid exporter; Provisional; Region: PRK11689 1346614006390 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 1346614006391 chorismate mutase; Provisional; Region: PRK08055 1346614006392 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1346614006393 Beta-lactamase; Region: Beta-lactamase; pfam00144 1346614006394 N-formylglutamate amidohydrolase; Region: FGase; cl01522 1346614006395 imidazolonepropionase; Validated; Region: PRK09356 1346614006396 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1346614006397 active site 1346614006398 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 1346614006399 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1346614006400 DNA-binding site [nucleotide binding]; DNA binding site 1346614006401 UTRA domain; Region: UTRA; pfam07702 1346614006402 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 1346614006403 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 1346614006404 active site 1346614006405 HutD; Region: HutD; pfam05962 1346614006406 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1346614006407 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1346614006408 DNA binding site [nucleotide binding] 1346614006409 domain linker motif; other site 1346614006410 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 1346614006411 putative dimerization interface [polypeptide binding]; other site 1346614006412 putative ligand binding site [chemical binding]; other site 1346614006413 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1346614006414 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1346614006415 substrate binding [chemical binding]; other site 1346614006416 active site 1346614006417 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1346614006418 galactoside permease; Reviewed; Region: lacY; PRK09528 1346614006419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614006420 metabolite-proton symporter; Region: 2A0106; TIGR00883 1346614006421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614006422 putative substrate translocation pore; other site 1346614006423 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1346614006424 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1346614006425 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1346614006426 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1346614006427 active sites [active] 1346614006428 tetramer interface [polypeptide binding]; other site 1346614006429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614006430 metabolite-proton symporter; Region: 2A0106; TIGR00883 1346614006431 putative substrate translocation pore; other site 1346614006432 urocanate hydratase; Provisional; Region: PRK05414 1346614006433 Protein of unknown function (DUF917); Region: DUF917; pfam06032 1346614006434 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1346614006435 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614006436 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 1346614006437 putative dimerization interface [polypeptide binding]; other site 1346614006438 allantoinase; Region: allantoinase; TIGR03178 1346614006439 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1346614006440 active site 1346614006441 allantoate amidohydrolase; Reviewed; Region: PRK12890 1346614006442 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1346614006443 active site 1346614006444 metal binding site [ion binding]; metal-binding site 1346614006445 dimer interface [polypeptide binding]; other site 1346614006446 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1346614006447 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1346614006448 active site 1346614006449 substrate-binding site [chemical binding]; other site 1346614006450 metal-binding site [ion binding] 1346614006451 ATP binding site [chemical binding]; other site 1346614006452 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 1346614006453 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 1346614006454 active site 1346614006455 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1346614006456 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1346614006457 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 1346614006458 Spore Coat Protein U domain; Region: SCPU; pfam05229 1346614006459 Uncharacterized secreted protein [Function unknown]; Region: COG5430 1346614006460 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1346614006461 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1346614006462 PapC C-terminal domain; Region: PapC_C; pfam13953 1346614006463 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1346614006464 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1346614006465 Spore Coat Protein U domain; Region: SCPU; pfam05229 1346614006466 Spore Coat Protein U domain; Region: SCPU; pfam05229 1346614006467 Spore Coat Protein U domain; Region: SCPU; pfam05229 1346614006468 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 1346614006469 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614006470 S-adenosylmethionine binding site [chemical binding]; other site 1346614006471 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1346614006472 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1346614006473 mce related protein; Region: MCE; pfam02470 1346614006474 mce related protein; Region: MCE; pfam02470 1346614006475 mce related protein; Region: MCE; pfam02470 1346614006476 mce related protein; Region: MCE; pfam02470 1346614006477 mce related protein; Region: MCE; pfam02470 1346614006478 mce related protein; Region: MCE; pfam02470 1346614006479 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 1346614006480 Paraquat-inducible protein A; Region: PqiA; pfam04403 1346614006481 Paraquat-inducible protein A; Region: PqiA; pfam04403 1346614006482 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1346614006483 GAF domain; Region: GAF_2; pfam13185 1346614006484 ProP expression regulator; Provisional; Region: PRK04950 1346614006485 ProQ/FINO family; Region: ProQ; pfam04352 1346614006486 putative RNA binding sites [nucleotide binding]; other site 1346614006487 carboxy-terminal protease; Provisional; Region: PRK11186 1346614006488 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1346614006489 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1346614006490 protein binding site [polypeptide binding]; other site 1346614006491 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1346614006492 Catalytic dyad [active] 1346614006493 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1346614006494 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 1346614006495 heat shock protein HtpX; Provisional; Region: PRK05457 1346614006496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614006497 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1346614006498 putative substrate translocation pore; other site 1346614006499 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614006500 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 1346614006501 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1346614006502 dimerization interface [polypeptide binding]; other site 1346614006503 putative Zn2+ binding site [ion binding]; other site 1346614006504 putative DNA binding site [nucleotide binding]; other site 1346614006505 Bacterial transcriptional regulator; Region: IclR; pfam01614 1346614006506 transcriptional regulator protein; Region: phnR; TIGR03337 1346614006507 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1346614006508 DNA-binding site [nucleotide binding]; DNA binding site 1346614006509 UTRA domain; Region: UTRA; pfam07702 1346614006510 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 1346614006511 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1346614006512 catalytic residue [active] 1346614006513 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 1346614006514 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1346614006515 motif II; other site 1346614006516 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1346614006517 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1346614006518 inner membrane protein; Provisional; Region: PRK11648 1346614006519 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 1346614006520 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1346614006521 motif II; other site 1346614006522 YniB-like protein; Region: YniB; pfam14002 1346614006523 Fructosamine kinase; Region: Fructosamin_kin; pfam03881 1346614006524 Phosphotransferase enzyme family; Region: APH; pfam01636 1346614006525 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614006526 Coenzyme A binding pocket [chemical binding]; other site 1346614006527 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1346614006528 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1346614006529 ABC-ATPase subunit interface; other site 1346614006530 dimer interface [polypeptide binding]; other site 1346614006531 putative PBP binding regions; other site 1346614006532 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1346614006533 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1346614006534 ABC-ATPase subunit interface; other site 1346614006535 dimer interface [polypeptide binding]; other site 1346614006536 putative PBP binding regions; other site 1346614006537 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 1346614006538 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1346614006539 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1346614006540 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1346614006541 metal binding site [ion binding]; metal-binding site 1346614006542 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 1346614006543 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 1346614006544 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1346614006545 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1346614006546 catalytic residue [active] 1346614006547 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1346614006548 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1346614006549 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1346614006550 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1346614006551 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1346614006552 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1346614006553 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1346614006554 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1346614006555 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1346614006556 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1346614006557 intersubunit interface [polypeptide binding]; other site 1346614006558 inner membrane protein; Provisional; Region: PRK10995 1346614006559 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 1346614006560 Flagellar FliJ protein; Region: FliJ; pfam02050 1346614006561 S-type Pyocin; Region: Pyocin_S; pfam06958 1346614006562 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1346614006563 active site 1346614006564 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1346614006565 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1346614006566 cofactor binding site; other site 1346614006567 DNA binding site [nucleotide binding] 1346614006568 substrate interaction site [chemical binding]; other site 1346614006569 Predicted transcriptional regulator [Transcription]; Region: COG2932 1346614006570 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1346614006571 Catalytic site [active] 1346614006572 Bacteriophage CII protein; Region: Phage_CII; pfam05269 1346614006573 KilA-N domain; Region: KilA-N; pfam04383 1346614006574 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 1346614006575 Helix-turn-helix domain; Region: HTH_36; pfam13730 1346614006576 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; cl09752 1346614006577 Protein of unknown function (DUF968); Region: DUF968; pfam06147 1346614006578 Endodeoxyribonuclease RusA; Region: RusA; cl01885 1346614006579 uncharacterized phage protein; Region: phage_xxxx; TIGR02642 1346614006580 Antitermination protein; Region: Antiterm; pfam03589 1346614006581 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 1346614006582 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1346614006583 catalytic residues [active] 1346614006584 Terminase small subunit; Region: Terminase_2; pfam03592 1346614006585 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 1346614006586 tape measure domain; Region: tape_meas_nterm; TIGR02675 1346614006587 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 1346614006588 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1346614006589 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1346614006590 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1346614006591 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1346614006592 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1346614006593 active site 1346614006594 dimer interface [polypeptide binding]; other site 1346614006595 motif 1; other site 1346614006596 motif 2; other site 1346614006597 motif 3; other site 1346614006598 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1346614006599 anticodon binding site; other site 1346614006600 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1346614006601 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1346614006602 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1346614006603 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1346614006604 23S rRNA binding site [nucleotide binding]; other site 1346614006605 L21 binding site [polypeptide binding]; other site 1346614006606 L13 binding site [polypeptide binding]; other site 1346614006607 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1346614006608 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1346614006609 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1346614006610 dimer interface [polypeptide binding]; other site 1346614006611 motif 1; other site 1346614006612 active site 1346614006613 motif 2; other site 1346614006614 motif 3; other site 1346614006615 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1346614006616 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1346614006617 putative tRNA-binding site [nucleotide binding]; other site 1346614006618 B3/4 domain; Region: B3_4; pfam03483 1346614006619 tRNA synthetase B5 domain; Region: B5; smart00874 1346614006620 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1346614006621 dimer interface [polypeptide binding]; other site 1346614006622 motif 1; other site 1346614006623 motif 3; other site 1346614006624 motif 2; other site 1346614006625 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1346614006626 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1346614006627 IHF dimer interface [polypeptide binding]; other site 1346614006628 IHF - DNA interface [nucleotide binding]; other site 1346614006629 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 1346614006630 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1346614006631 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1346614006632 ABC-ATPase subunit interface; other site 1346614006633 dimer interface [polypeptide binding]; other site 1346614006634 putative PBP binding regions; other site 1346614006635 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1346614006636 catalytic residues [active] 1346614006637 dimer interface [polypeptide binding]; other site 1346614006638 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 1346614006639 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1346614006640 Walker A/P-loop; other site 1346614006641 ATP binding site [chemical binding]; other site 1346614006642 Q-loop/lid; other site 1346614006643 ABC transporter signature motif; other site 1346614006644 Walker B; other site 1346614006645 D-loop; other site 1346614006646 H-loop/switch region; other site 1346614006647 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1346614006648 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1346614006649 inhibitor-cofactor binding pocket; inhibition site 1346614006650 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614006651 catalytic residue [active] 1346614006652 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1346614006653 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1346614006654 Ligand binding site; other site 1346614006655 Putative Catalytic site; other site 1346614006656 DXD motif; other site 1346614006657 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 1346614006658 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1346614006659 active site 1346614006660 substrate binding site [chemical binding]; other site 1346614006661 cosubstrate binding site; other site 1346614006662 catalytic site [active] 1346614006663 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 1346614006664 active site 1346614006665 hexamer interface [polypeptide binding]; other site 1346614006666 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1346614006667 NAD binding site [chemical binding]; other site 1346614006668 substrate binding site [chemical binding]; other site 1346614006669 active site 1346614006670 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 1346614006671 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 1346614006672 putative active site [active] 1346614006673 putative catalytic site [active] 1346614006674 putative Zn binding site [ion binding]; other site 1346614006675 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1346614006676 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 1346614006677 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 1346614006678 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 1346614006679 NlpC/P60 family; Region: NLPC_P60; pfam00877 1346614006680 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 1346614006681 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1346614006682 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1346614006683 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1346614006684 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1346614006685 hypothetical protein; Validated; Region: PRK00029 1346614006686 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1346614006687 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1346614006688 Walker A/P-loop; other site 1346614006689 ATP binding site [chemical binding]; other site 1346614006690 Q-loop/lid; other site 1346614006691 ABC transporter signature motif; other site 1346614006692 Walker B; other site 1346614006693 D-loop; other site 1346614006694 H-loop/switch region; other site 1346614006695 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1346614006696 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1346614006697 ABC-ATPase subunit interface; other site 1346614006698 dimer interface [polypeptide binding]; other site 1346614006699 putative PBP binding regions; other site 1346614006700 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 1346614006701 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 1346614006702 putative hemin binding site; other site 1346614006703 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 1346614006704 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1346614006705 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1346614006706 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1346614006707 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1346614006708 N-terminal plug; other site 1346614006709 ligand-binding site [chemical binding]; other site 1346614006710 Hemin uptake protein hemP; Region: hemP; pfam10636 1346614006711 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1346614006712 catalytic residues [active] 1346614006713 dimer interface [polypeptide binding]; other site 1346614006714 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 1346614006715 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1346614006716 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1346614006717 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1346614006718 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1346614006719 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1346614006720 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1346614006721 peptide synthase; Provisional; Region: PRK09274 1346614006722 putative inner membrane protein; Provisional; Region: PRK10983 1346614006723 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1346614006724 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1346614006725 FAD binding domain; Region: FAD_binding_4; pfam01565 1346614006726 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1346614006727 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1346614006728 CoenzymeA binding site [chemical binding]; other site 1346614006729 subunit interaction site [polypeptide binding]; other site 1346614006730 PHB binding site; other site 1346614006731 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 1346614006732 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1346614006733 putative ABC transporter; Region: ycf24; CHL00085 1346614006734 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 1346614006735 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1346614006736 Walker A/P-loop; other site 1346614006737 ATP binding site [chemical binding]; other site 1346614006738 Q-loop/lid; other site 1346614006739 ABC transporter signature motif; other site 1346614006740 Walker B; other site 1346614006741 D-loop; other site 1346614006742 H-loop/switch region; other site 1346614006743 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 1346614006744 FeS assembly protein SufD; Region: sufD; TIGR01981 1346614006745 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1346614006746 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1346614006747 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1346614006748 catalytic residue [active] 1346614006749 cysteine desufuration protein SufE; Provisional; Region: PRK09296 1346614006750 L,D-transpeptidase; Provisional; Region: PRK10190 1346614006751 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1346614006752 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1346614006753 murein lipoprotein; Provisional; Region: PRK15396 1346614006754 pyruvate kinase; Provisional; Region: PRK09206 1346614006755 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1346614006756 domain interfaces; other site 1346614006757 active site 1346614006758 Cupin domain; Region: Cupin_2; cl17218 1346614006759 multidrug efflux protein; Reviewed; Region: PRK01766 1346614006760 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1346614006761 cation binding site [ion binding]; other site 1346614006762 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 1346614006763 Lumazine binding domain; Region: Lum_binding; pfam00677 1346614006764 Lumazine binding domain; Region: Lum_binding; pfam00677 1346614006765 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 1346614006766 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 1346614006767 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1346614006768 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614006769 S-adenosylmethionine binding site [chemical binding]; other site 1346614006770 putative transporter; Provisional; Region: PRK11043 1346614006771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614006772 putative substrate translocation pore; other site 1346614006773 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1346614006774 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614006775 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1346614006776 dimerization interface [polypeptide binding]; other site 1346614006777 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 1346614006778 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1346614006779 DNA binding site [nucleotide binding] 1346614006780 domain linker motif; other site 1346614006781 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1346614006782 dimerization interface [polypeptide binding]; other site 1346614006783 ligand binding site [chemical binding]; other site 1346614006784 superoxide dismutase; Provisional; Region: PRK10543 1346614006785 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1346614006786 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1346614006787 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1346614006788 NlpC/P60 family; Region: NLPC_P60; pfam00877 1346614006789 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1346614006790 putative GSH binding site [chemical binding]; other site 1346614006791 catalytic residues [active] 1346614006792 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1346614006793 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 1346614006794 dimer interface [polypeptide binding]; other site 1346614006795 catalytic site [active] 1346614006796 putative active site [active] 1346614006797 putative substrate binding site [chemical binding]; other site 1346614006798 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1346614006799 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1346614006800 dimer interface [polypeptide binding]; other site 1346614006801 active site 1346614006802 glutathione binding site [chemical binding]; other site 1346614006803 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1346614006804 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 1346614006805 active site 1346614006806 metal binding site [ion binding]; metal-binding site 1346614006807 nudix motif; other site 1346614006808 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1346614006809 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1346614006810 FMN binding site [chemical binding]; other site 1346614006811 active site 1346614006812 substrate binding site [chemical binding]; other site 1346614006813 catalytic residue [active] 1346614006814 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1346614006815 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1346614006816 putative metal dependent hydrolase; Provisional; Region: PRK11598 1346614006817 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1346614006818 Sulfatase; Region: Sulfatase; pfam00884 1346614006819 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1346614006820 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1346614006821 NAD binding site [chemical binding]; other site 1346614006822 substrate binding site [chemical binding]; other site 1346614006823 putative active site [active] 1346614006824 transcriptional regulator; Provisional; Region: PRK10632 1346614006825 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614006826 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1346614006827 putative effector binding pocket; other site 1346614006828 dimerization interface [polypeptide binding]; other site 1346614006829 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1346614006830 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1346614006831 active site 1346614006832 catalytic tetrad [active] 1346614006833 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1346614006834 nucleophilic elbow; other site 1346614006835 catalytic triad; other site 1346614006836 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1346614006837 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1346614006838 E-class dimer interface [polypeptide binding]; other site 1346614006839 P-class dimer interface [polypeptide binding]; other site 1346614006840 active site 1346614006841 Cu2+ binding site [ion binding]; other site 1346614006842 Zn2+ binding site [ion binding]; other site 1346614006843 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1346614006844 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1346614006845 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1346614006846 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1346614006847 HlyD family secretion protein; Region: HlyD_3; pfam13437 1346614006848 transcriptional regulator SlyA; Provisional; Region: PRK03573 1346614006849 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1346614006850 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 1346614006851 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1346614006852 lysozyme inhibitor; Provisional; Region: PRK11372 1346614006853 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1346614006854 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1346614006855 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1346614006856 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1346614006857 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1346614006858 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1346614006859 active site 1346614006860 HIGH motif; other site 1346614006861 dimer interface [polypeptide binding]; other site 1346614006862 KMSKS motif; other site 1346614006863 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1346614006864 RNA binding surface [nucleotide binding]; other site 1346614006865 pyridoxamine kinase; Validated; Region: PRK05756 1346614006866 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1346614006867 dimer interface [polypeptide binding]; other site 1346614006868 pyridoxal binding site [chemical binding]; other site 1346614006869 ATP binding site [chemical binding]; other site 1346614006870 glutathionine S-transferase; Provisional; Region: PRK10542 1346614006871 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1346614006872 C-terminal domain interface [polypeptide binding]; other site 1346614006873 GSH binding site (G-site) [chemical binding]; other site 1346614006874 dimer interface [polypeptide binding]; other site 1346614006875 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1346614006876 dimer interface [polypeptide binding]; other site 1346614006877 N-terminal domain interface [polypeptide binding]; other site 1346614006878 substrate binding pocket (H-site) [chemical binding]; other site 1346614006879 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1346614006880 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1346614006881 dimer interface [polypeptide binding]; other site 1346614006882 active site 1346614006883 catalytic residue [active] 1346614006884 YjbD family (DUF3811); Region: DUF3811; pfam11656 1346614006885 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1346614006886 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1346614006887 Zn2+ binding site [ion binding]; other site 1346614006888 Mg2+ binding site [ion binding]; other site 1346614006889 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1346614006890 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1346614006891 homotrimer interaction site [polypeptide binding]; other site 1346614006892 putative active site [active] 1346614006893 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 1346614006894 Cupin domain; Region: Cupin_2; cl17218 1346614006895 benzoate transporter; Region: benE; TIGR00843 1346614006896 Benzoate membrane transport protein; Region: BenE; pfam03594 1346614006897 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1346614006898 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1346614006899 non-specific DNA binding site [nucleotide binding]; other site 1346614006900 salt bridge; other site 1346614006901 sequence-specific DNA binding site [nucleotide binding]; other site 1346614006902 Cupin domain; Region: Cupin_2; pfam07883 1346614006903 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1346614006904 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1346614006905 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1346614006906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614006907 putative substrate translocation pore; other site 1346614006908 POT family; Region: PTR2; pfam00854 1346614006909 endonuclease III; Provisional; Region: PRK10702 1346614006910 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1346614006911 minor groove reading motif; other site 1346614006912 helix-hairpin-helix signature motif; other site 1346614006913 substrate binding pocket [chemical binding]; other site 1346614006914 active site 1346614006915 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1346614006916 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1346614006917 electron transport complex protein RnfG; Validated; Region: PRK01908 1346614006918 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 1346614006919 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1346614006920 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614006921 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1346614006922 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 1346614006923 SLBB domain; Region: SLBB; pfam10531 1346614006924 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1346614006925 ferredoxin; Provisional; Region: PRK08764 1346614006926 Putative Fe-S cluster; Region: FeS; cl17515 1346614006927 4Fe-4S binding domain; Region: Fer4; pfam00037 1346614006928 electron transport complex protein RsxA; Provisional; Region: PRK05151 1346614006929 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 1346614006930 L-arabinose isomerase; Provisional; Region: PRK02929 1346614006931 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1346614006932 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1346614006933 trimer interface [polypeptide binding]; other site 1346614006934 putative substrate binding site [chemical binding]; other site 1346614006935 putative metal binding site [ion binding]; other site 1346614006936 ribulokinase; Provisional; Region: PRK04123 1346614006937 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1346614006938 N- and C-terminal domain interface [polypeptide binding]; other site 1346614006939 active site 1346614006940 MgATP binding site [chemical binding]; other site 1346614006941 catalytic site [active] 1346614006942 metal binding site [ion binding]; metal-binding site 1346614006943 carbohydrate binding site [chemical binding]; other site 1346614006944 homodimer interface [polypeptide binding]; other site 1346614006945 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1346614006946 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 1346614006947 ligand binding site [chemical binding]; other site 1346614006948 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 1346614006949 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1346614006950 Walker A/P-loop; other site 1346614006951 ATP binding site [chemical binding]; other site 1346614006952 Q-loop/lid; other site 1346614006953 ABC transporter signature motif; other site 1346614006954 Walker B; other site 1346614006955 D-loop; other site 1346614006956 H-loop/switch region; other site 1346614006957 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1346614006958 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1346614006959 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1346614006960 TM-ABC transporter signature motif; other site 1346614006961 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 1346614006962 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1346614006963 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614006964 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614006965 putative oxidoreductase; Provisional; Region: PRK11579 1346614006966 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1346614006967 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1346614006968 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1346614006969 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1346614006970 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1346614006971 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1346614006972 active site 1346614006973 purine riboside binding site [chemical binding]; other site 1346614006974 AAA domain; Region: AAA_17; pfam13207 1346614006975 AAA domain; Region: AAA_18; pfam13238 1346614006976 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1346614006977 active site 1346614006978 phosphorylation site [posttranslational modification] 1346614006979 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 1346614006980 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1346614006981 intersubunit interface [polypeptide binding]; other site 1346614006982 active site 1346614006983 zinc binding site [ion binding]; other site 1346614006984 Na+ binding site [ion binding]; other site 1346614006985 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 1346614006986 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1346614006987 active site 1346614006988 P-loop; other site 1346614006989 phosphorylation site [posttranslational modification] 1346614006990 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 1346614006991 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1346614006992 active site 1346614006993 ADP/pyrophosphate binding site [chemical binding]; other site 1346614006994 dimerization interface [polypeptide binding]; other site 1346614006995 allosteric effector site; other site 1346614006996 fructose-1,6-bisphosphate binding site; other site 1346614006997 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1346614006998 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1346614006999 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1346614007000 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1346614007001 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1346614007002 dimer interface [polypeptide binding]; other site 1346614007003 ADP-ribose binding site [chemical binding]; other site 1346614007004 active site 1346614007005 nudix motif; other site 1346614007006 metal binding site [ion binding]; metal-binding site 1346614007007 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 1346614007008 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1346614007009 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1346614007010 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614007011 homodimer interface [polypeptide binding]; other site 1346614007012 catalytic residue [active] 1346614007013 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 1346614007014 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1346614007015 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1346614007016 active site turn [active] 1346614007017 phosphorylation site [posttranslational modification] 1346614007018 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 1346614007019 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1346614007020 DNA binding site [nucleotide binding] 1346614007021 domain linker motif; other site 1346614007022 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 1346614007023 putative dimerization interface [polypeptide binding]; other site 1346614007024 putative ligand binding site [chemical binding]; other site 1346614007025 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1346614007026 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614007027 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1346614007028 dimerization interface [polypeptide binding]; other site 1346614007029 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 1346614007030 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1346614007031 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1346614007032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614007033 putative substrate translocation pore; other site 1346614007034 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1346614007035 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1346614007036 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614007037 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614007038 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1346614007039 putative effector binding pocket; other site 1346614007040 putative dimerization interface [polypeptide binding]; other site 1346614007041 Beta-lactamase; Region: Beta-lactamase; pfam00144 1346614007042 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1346614007043 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 1346614007044 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1346614007045 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 1346614007046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1346614007047 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 1346614007048 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1346614007049 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1346614007050 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1346614007051 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1346614007052 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1346614007053 Class II fumarases; Region: Fumarase_classII; cd01362 1346614007054 active site 1346614007055 tetramer interface [polypeptide binding]; other site 1346614007056 Predicted transcriptional regulator [Transcription]; Region: COG2378 1346614007057 HTH domain; Region: HTH_11; pfam08279 1346614007058 WYL domain; Region: WYL; pfam13280 1346614007059 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1346614007060 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 1346614007061 putative dimer interface [polypeptide binding]; other site 1346614007062 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 1346614007063 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1346614007064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614007065 putative substrate translocation pore; other site 1346614007066 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1346614007067 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614007068 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1346614007069 dimerization interface [polypeptide binding]; other site 1346614007070 substrate binding pocket [chemical binding]; other site 1346614007071 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1346614007072 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1346614007073 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1346614007074 nucleotide binding site [chemical binding]; other site 1346614007075 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1346614007076 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 1346614007077 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1346614007078 Cl- selectivity filter; other site 1346614007079 Cl- binding residues [ion binding]; other site 1346614007080 pore gating glutamate residue; other site 1346614007081 dimer interface [polypeptide binding]; other site 1346614007082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614007083 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1346614007084 putative substrate translocation pore; other site 1346614007085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614007086 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1346614007087 hypothetical protein; Provisional; Region: PRK13659 1346614007088 hypothetical protein; Provisional; Region: PRK02237 1346614007089 malonic semialdehyde reductase; Provisional; Region: PRK10538 1346614007090 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1346614007091 putative NAD(P) binding site [chemical binding]; other site 1346614007092 homodimer interface [polypeptide binding]; other site 1346614007093 homotetramer interface [polypeptide binding]; other site 1346614007094 active site 1346614007095 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1346614007096 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1346614007097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614007098 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1346614007099 putative substrate translocation pore; other site 1346614007100 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 1346614007101 Secretin and TonB N terminus short domain; Region: STN; smart00965 1346614007102 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1346614007103 N-terminal plug; other site 1346614007104 ligand-binding site [chemical binding]; other site 1346614007105 fec operon regulator FecR; Reviewed; Region: PRK09774 1346614007106 FecR protein; Region: FecR; pfam04773 1346614007107 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 1346614007108 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1346614007109 DNA binding residues [nucleotide binding] 1346614007110 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1346614007111 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1346614007112 Walker A/P-loop; other site 1346614007113 ATP binding site [chemical binding]; other site 1346614007114 Q-loop/lid; other site 1346614007115 ABC transporter signature motif; other site 1346614007116 Walker B; other site 1346614007117 D-loop; other site 1346614007118 H-loop/switch region; other site 1346614007119 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1346614007120 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1346614007121 substrate binding site [chemical binding]; other site 1346614007122 ATP binding site [chemical binding]; other site 1346614007123 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1346614007124 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614007125 dimer interface [polypeptide binding]; other site 1346614007126 conserved gate region; other site 1346614007127 putative PBP binding loops; other site 1346614007128 ABC-ATPase subunit interface; other site 1346614007129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614007130 dimer interface [polypeptide binding]; other site 1346614007131 conserved gate region; other site 1346614007132 putative PBP binding loops; other site 1346614007133 ABC-ATPase subunit interface; other site 1346614007134 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1346614007135 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1346614007136 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1346614007137 non-specific DNA interactions [nucleotide binding]; other site 1346614007138 DNA binding site [nucleotide binding] 1346614007139 sequence specific DNA binding site [nucleotide binding]; other site 1346614007140 putative cAMP binding site [chemical binding]; other site 1346614007141 fructokinase; Reviewed; Region: PRK09557 1346614007142 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1346614007143 nucleotide binding site [chemical binding]; other site 1346614007144 guanine deaminase; Provisional; Region: PRK09228 1346614007145 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 1346614007146 active site 1346614007147 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 1346614007148 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1346614007149 catalytic loop [active] 1346614007150 iron binding site [ion binding]; other site 1346614007151 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1346614007152 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1346614007153 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 1346614007154 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1346614007155 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1346614007156 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1346614007157 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 1346614007158 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1346614007159 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 1346614007160 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1346614007161 active site 1346614007162 Zn binding site [ion binding]; other site 1346614007163 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1346614007164 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614007165 putative substrate translocation pore; other site 1346614007166 Isochorismatase family; Region: Isochorismatase; pfam00857 1346614007167 N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015 1346614007168 catalytic triad [active] 1346614007169 substrate binding site [chemical binding]; other site 1346614007170 domain interfaces; other site 1346614007171 conserved cis-peptide bond; other site 1346614007172 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1346614007173 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1346614007174 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1346614007175 catalytic site [active] 1346614007176 hypothetical protein; Provisional; Region: PRK06847 1346614007177 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1346614007178 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1346614007179 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1346614007180 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1346614007181 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1346614007182 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1346614007183 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1346614007184 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1346614007185 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1346614007186 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1346614007187 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1346614007188 Cytochrome c; Region: Cytochrom_C; pfam00034 1346614007189 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1346614007190 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1346614007191 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1346614007192 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614007193 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 1346614007194 putative dimerization interface [polypeptide binding]; other site 1346614007195 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614007196 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614007197 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1346614007198 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1346614007199 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1346614007200 HlyD family secretion protein; Region: HlyD_3; pfam13437 1346614007201 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1346614007202 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 1346614007203 putative active site [active] 1346614007204 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1346614007205 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1346614007206 Walker A/P-loop; other site 1346614007207 ATP binding site [chemical binding]; other site 1346614007208 Q-loop/lid; other site 1346614007209 ABC transporter signature motif; other site 1346614007210 Walker B; other site 1346614007211 D-loop; other site 1346614007212 H-loop/switch region; other site 1346614007213 hypothetical protein; Provisional; Region: PRK07236 1346614007214 FAD binding domain; Region: FAD_binding_3; pfam01494 1346614007215 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1346614007216 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1346614007217 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1346614007218 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1346614007219 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1346614007220 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1346614007221 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1346614007222 catalytic loop [active] 1346614007223 iron binding site [ion binding]; other site 1346614007224 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1346614007225 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1346614007226 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1346614007227 Cytochrome c; Region: Cytochrom_C; pfam00034 1346614007228 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1346614007229 Cupin; Region: Cupin_1; smart00835 1346614007230 Cupin; Region: Cupin_1; smart00835 1346614007231 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1346614007232 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1346614007233 active site turn [active] 1346614007234 phosphorylation site [posttranslational modification] 1346614007235 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1346614007236 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1346614007237 HPr interaction site; other site 1346614007238 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1346614007239 active site 1346614007240 phosphorylation site [posttranslational modification] 1346614007241 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1346614007242 beta-galactosidase; Region: BGL; TIGR03356 1346614007243 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1346614007244 CAT RNA binding domain; Region: CAT_RBD; smart01061 1346614007245 PRD domain; Region: PRD; pfam00874 1346614007246 PRD domain; Region: PRD; pfam00874 1346614007247 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1346614007248 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614007249 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 1346614007250 putative dimerization interface [polypeptide binding]; other site 1346614007251 putative substrate binding pocket [chemical binding]; other site 1346614007252 Chromate transporter; Region: Chromate_transp; pfam02417 1346614007253 Chromate transporter; Region: Chromate_transp; pfam02417 1346614007254 Protease inhibitor Inh; Region: Inh; pfam02974 1346614007255 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 1346614007256 active site 1346614007257 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1346614007258 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1346614007259 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1346614007260 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1346614007261 classical (c) SDRs; Region: SDR_c; cd05233 1346614007262 NAD(P) binding site [chemical binding]; other site 1346614007263 short chain dehydrogenase; Provisional; Region: PRK07577 1346614007264 active site 1346614007265 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1346614007266 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1346614007267 DNA binding site [nucleotide binding] 1346614007268 domain linker motif; other site 1346614007269 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 1346614007270 putative ligand binding site [chemical binding]; other site 1346614007271 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1346614007272 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1346614007273 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1346614007274 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 1346614007275 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1346614007276 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1346614007277 Cytochrome c; Region: Cytochrom_C; pfam00034 1346614007278 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1346614007279 EamA-like transporter family; Region: EamA; pfam00892 1346614007280 Helix-turn-helix domain; Region: HTH_18; pfam12833 1346614007281 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614007282 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1346614007283 active site 1346614007284 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1346614007285 drug efflux system protein MdtG; Provisional; Region: PRK09874 1346614007286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614007287 putative substrate translocation pore; other site 1346614007288 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614007289 Coenzyme A binding pocket [chemical binding]; other site 1346614007290 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1346614007291 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1346614007292 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1346614007293 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 1346614007294 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1346614007295 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 1346614007296 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1346614007297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614007298 dimer interface [polypeptide binding]; other site 1346614007299 conserved gate region; other site 1346614007300 putative PBP binding loops; other site 1346614007301 ABC-ATPase subunit interface; other site 1346614007302 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 1346614007303 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1346614007304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614007305 dimer interface [polypeptide binding]; other site 1346614007306 conserved gate region; other site 1346614007307 putative PBP binding loops; other site 1346614007308 ABC-ATPase subunit interface; other site 1346614007309 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1346614007310 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1346614007311 Walker A/P-loop; other site 1346614007312 ATP binding site [chemical binding]; other site 1346614007313 Q-loop/lid; other site 1346614007314 ABC transporter signature motif; other site 1346614007315 Walker B; other site 1346614007316 D-loop; other site 1346614007317 H-loop/switch region; other site 1346614007318 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1346614007319 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1346614007320 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1346614007321 Walker A/P-loop; other site 1346614007322 ATP binding site [chemical binding]; other site 1346614007323 Q-loop/lid; other site 1346614007324 ABC transporter signature motif; other site 1346614007325 Walker B; other site 1346614007326 D-loop; other site 1346614007327 H-loop/switch region; other site 1346614007328 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1346614007329 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1346614007330 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1346614007331 active site 1346614007332 penicillin-binding protein 2; Provisional; Region: PRK10795 1346614007333 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1346614007334 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1346614007335 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1346614007336 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1346614007337 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1346614007338 lipoprotein; Provisional; Region: PRK10540 1346614007339 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 1346614007340 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1346614007341 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1346614007342 Walker A/P-loop; other site 1346614007343 ATP binding site [chemical binding]; other site 1346614007344 Q-loop/lid; other site 1346614007345 ABC transporter signature motif; other site 1346614007346 Walker B; other site 1346614007347 D-loop; other site 1346614007348 H-loop/switch region; other site 1346614007349 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1346614007350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614007351 dimer interface [polypeptide binding]; other site 1346614007352 conserved gate region; other site 1346614007353 putative PBP binding loops; other site 1346614007354 ABC-ATPase subunit interface; other site 1346614007355 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1346614007356 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1346614007357 substrate binding pocket [chemical binding]; other site 1346614007358 membrane-bound complex binding site; other site 1346614007359 hinge residues; other site 1346614007360 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1346614007361 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1346614007362 active site 1346614007363 non-prolyl cis peptide bond; other site 1346614007364 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1346614007365 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1346614007366 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1346614007367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614007368 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1346614007369 putative substrate translocation pore; other site 1346614007370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614007371 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1346614007372 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1346614007373 Uncharacterized conserved protein [Function unknown]; Region: COG5276 1346614007374 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 1346614007375 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1346614007376 putative ligand binding site [chemical binding]; other site 1346614007377 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1346614007378 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1346614007379 putative active site [active] 1346614007380 metal binding site [ion binding]; metal-binding site 1346614007381 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1346614007382 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614007383 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1346614007384 hypothetical protein; Provisional; Region: PRK05208 1346614007385 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 1346614007386 active site 1346614007387 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1346614007388 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1346614007389 N-terminal plug; other site 1346614007390 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1346614007391 ligand-binding site [chemical binding]; other site 1346614007392 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 1346614007393 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1346614007394 putative hemin binding site; other site 1346614007395 Rdx family; Region: Rdx; cl01407 1346614007396 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1346614007397 Bacterial transcriptional regulator; Region: IclR; pfam01614 1346614007398 PAS domain; Region: PAS; smart00091 1346614007399 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1346614007400 Walker A motif; other site 1346614007401 ATP binding site [chemical binding]; other site 1346614007402 Walker B motif; other site 1346614007403 arginine finger; other site 1346614007404 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1346614007405 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1346614007406 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1346614007407 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1346614007408 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 1346614007409 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1346614007410 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 1346614007411 putative ligand binding site [chemical binding]; other site 1346614007412 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1346614007413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614007414 putative substrate translocation pore; other site 1346614007415 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614007416 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614007417 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1346614007418 putative effector binding pocket; other site 1346614007419 dimerization interface [polypeptide binding]; other site 1346614007420 Amidinotransferase; Region: Amidinotransf; cl12043 1346614007421 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1346614007422 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1346614007423 substrate binding pocket [chemical binding]; other site 1346614007424 membrane-bound complex binding site; other site 1346614007425 hinge residues; other site 1346614007426 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1346614007427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614007428 dimer interface [polypeptide binding]; other site 1346614007429 conserved gate region; other site 1346614007430 putative PBP binding loops; other site 1346614007431 ABC-ATPase subunit interface; other site 1346614007432 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1346614007433 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614007434 dimer interface [polypeptide binding]; other site 1346614007435 conserved gate region; other site 1346614007436 putative PBP binding loops; other site 1346614007437 ABC-ATPase subunit interface; other site 1346614007438 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1346614007439 dimerization interface [polypeptide binding]; other site 1346614007440 putative DNA binding site [nucleotide binding]; other site 1346614007441 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1346614007442 putative Zn2+ binding site [ion binding]; other site 1346614007443 AsnC family; Region: AsnC_trans_reg; pfam01037 1346614007444 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 1346614007445 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1346614007446 active site 1346614007447 Zn binding site [ion binding]; other site 1346614007448 Fic/DOC family; Region: Fic; pfam02661 1346614007449 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1346614007450 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1346614007451 Walker A/P-loop; other site 1346614007452 ATP binding site [chemical binding]; other site 1346614007453 Q-loop/lid; other site 1346614007454 ABC transporter signature motif; other site 1346614007455 Walker B; other site 1346614007456 D-loop; other site 1346614007457 H-loop/switch region; other site 1346614007458 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1346614007459 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1346614007460 NAD binding site [chemical binding]; other site 1346614007461 substrate binding site [chemical binding]; other site 1346614007462 catalytic Zn binding site [ion binding]; other site 1346614007463 tetramer interface [polypeptide binding]; other site 1346614007464 structural Zn binding site [ion binding]; other site 1346614007465 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Region: ALDH_ACDHII_AcoD-like; cd07559 1346614007466 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1346614007467 NAD(P) binding site [chemical binding]; other site 1346614007468 catalytic residues [active] 1346614007469 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1346614007470 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1346614007471 Walker A motif; other site 1346614007472 ATP binding site [chemical binding]; other site 1346614007473 Walker B motif; other site 1346614007474 arginine finger; other site 1346614007475 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1346614007476 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1346614007477 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1346614007478 substrate binding pocket [chemical binding]; other site 1346614007479 membrane-bound complex binding site; other site 1346614007480 hinge residues; other site 1346614007481 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1346614007482 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614007483 Coenzyme A binding pocket [chemical binding]; other site 1346614007484 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1346614007485 heme pocket [chemical binding]; other site 1346614007486 putative active site [active] 1346614007487 PAS fold; Region: PAS_4; pfam08448 1346614007488 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1346614007489 putative active site [active] 1346614007490 heme pocket [chemical binding]; other site 1346614007491 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1346614007492 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1346614007493 metal binding site [ion binding]; metal-binding site 1346614007494 active site 1346614007495 I-site; other site 1346614007496 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1346614007497 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1346614007498 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1346614007499 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1346614007500 Trp docking motif [polypeptide binding]; other site 1346614007501 putative active site [active] 1346614007502 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614007503 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614007504 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1346614007505 putative effector binding pocket; other site 1346614007506 dimerization interface [polypeptide binding]; other site 1346614007507 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1346614007508 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 1346614007509 putative NAD(P) binding site [chemical binding]; other site 1346614007510 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1346614007511 putative catalytic site [active] 1346614007512 putative metal binding site [ion binding]; other site 1346614007513 putative catalytic site [active] 1346614007514 putative phosphate binding site [ion binding]; other site 1346614007515 putative phosphate binding site [ion binding]; other site 1346614007516 putative metal binding site [ion binding]; other site 1346614007517 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614007518 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614007519 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 1346614007520 putative substrate binding pocket [chemical binding]; other site 1346614007521 putative dimerization interface [polypeptide binding]; other site 1346614007522 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614007523 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614007524 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1346614007525 putative effector binding pocket; other site 1346614007526 putative dimerization interface [polypeptide binding]; other site 1346614007527 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1346614007528 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614007529 catalytic residue [active] 1346614007530 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 1346614007531 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1346614007532 inhibitor-cofactor binding pocket; inhibition site 1346614007533 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614007534 catalytic residue [active] 1346614007535 glucose-1-dehydrogenase; Provisional; Region: PRK06947 1346614007536 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 1346614007537 NADP binding site [chemical binding]; other site 1346614007538 substrate binding site [chemical binding]; other site 1346614007539 active site 1346614007540 choline dehydrogenase; Validated; Region: PRK02106 1346614007541 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1346614007542 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1346614007543 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 1346614007544 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1346614007545 NAD(P) binding site [chemical binding]; other site 1346614007546 catalytic residues [active] 1346614007547 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614007548 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614007549 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1346614007550 putative effector binding pocket; other site 1346614007551 dimerization interface [polypeptide binding]; other site 1346614007552 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 1346614007553 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1346614007554 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1346614007555 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1346614007556 NodB motif; other site 1346614007557 active site 1346614007558 catalytic site [active] 1346614007559 metal binding site [ion binding]; metal-binding site 1346614007560 choline dehydrogenase; Validated; Region: PRK02106 1346614007561 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1346614007562 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1346614007563 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1346614007564 putative NAD(P) binding site [chemical binding]; other site 1346614007565 putative active site [active] 1346614007566 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1346614007567 DNA-binding site [nucleotide binding]; DNA binding site 1346614007568 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 1346614007569 FCD domain; Region: FCD; pfam07729 1346614007570 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1346614007571 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1346614007572 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1346614007573 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1346614007574 NAD(P) binding site [chemical binding]; other site 1346614007575 catalytic residues [active] 1346614007576 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 1346614007577 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1346614007578 active site 1346614007579 metal binding site [ion binding]; metal-binding site 1346614007580 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1346614007581 active site 1346614007582 metal binding site [ion binding]; metal-binding site 1346614007583 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1346614007584 High-affinity nickel-transport protein; Region: NicO; cl00964 1346614007585 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1346614007586 Acylphosphatase; Region: Acylphosphatase; pfam00708 1346614007587 HypF finger; Region: zf-HYPF; pfam07503 1346614007588 HypF finger; Region: zf-HYPF; pfam07503 1346614007589 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1346614007590 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1346614007591 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1346614007592 [4Fe-4S] binding site [ion binding]; other site 1346614007593 molybdopterin cofactor binding site; other site 1346614007594 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 1346614007595 molybdopterin cofactor binding site; other site 1346614007596 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 1346614007597 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1346614007598 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 1346614007599 nickel binding site [ion binding]; other site 1346614007600 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 1346614007601 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1346614007602 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 1346614007603 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1346614007604 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 1346614007605 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1346614007606 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1346614007607 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1346614007608 NADH dehydrogenase; Region: NADHdh; cl00469 1346614007609 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 1346614007610 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1346614007611 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1346614007612 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 1346614007613 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 1346614007614 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 1346614007615 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 1346614007616 HupF/HypC family; Region: HupF_HypC; cl00394 1346614007617 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 1346614007618 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 1346614007619 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 1346614007620 dimerization interface [polypeptide binding]; other site 1346614007621 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 1346614007622 ATP binding site [chemical binding]; other site 1346614007623 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 1346614007624 GAF domain; Region: GAF; cl17456 1346614007625 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1346614007626 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1346614007627 Walker A motif; other site 1346614007628 ATP binding site [chemical binding]; other site 1346614007629 Walker B motif; other site 1346614007630 arginine finger; other site 1346614007631 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1346614007632 chaperone protein HchA; Provisional; Region: PRK04155 1346614007633 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1346614007634 conserved cys residue [active] 1346614007635 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1346614007636 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1346614007637 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1346614007638 putative active site [active] 1346614007639 heme pocket [chemical binding]; other site 1346614007640 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1346614007641 putative active site [active] 1346614007642 heme pocket [chemical binding]; other site 1346614007643 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1346614007644 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1346614007645 DNA binding residues [nucleotide binding] 1346614007646 dimerization interface [polypeptide binding]; other site 1346614007647 CsbD-like; Region: CsbD; pfam05532 1346614007648 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 1346614007649 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1346614007650 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 1346614007651 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1346614007652 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1346614007653 DNA binding residues [nucleotide binding] 1346614007654 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1346614007655 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1346614007656 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1346614007657 atypical (a) SDRs, subgroup 3; Region: SDR_a3; cd05229 1346614007658 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1346614007659 putative NAD(P) binding site [chemical binding]; other site 1346614007660 putative active site [active] 1346614007661 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1346614007662 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1346614007663 DNA binding residues [nucleotide binding] 1346614007664 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1346614007665 phosphate binding site [ion binding]; other site 1346614007666 permease DsdX; Provisional; Region: PRK09921 1346614007667 gluconate transporter; Region: gntP; TIGR00791 1346614007668 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 1346614007669 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614007670 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1346614007671 dimerization interface [polypeptide binding]; other site 1346614007672 substrate binding pocket [chemical binding]; other site 1346614007673 Carboxylesterase family; Region: COesterase; pfam00135 1346614007674 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1346614007675 substrate binding pocket [chemical binding]; other site 1346614007676 catalytic triad [active] 1346614007677 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 1346614007678 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1346614007679 N-terminal plug; other site 1346614007680 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 1346614007681 ligand-binding site [chemical binding]; other site 1346614007682 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614007683 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614007684 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 1346614007685 putative substrate binding pocket [chemical binding]; other site 1346614007686 putative dimerization interface [polypeptide binding]; other site 1346614007687 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1346614007688 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1346614007689 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1346614007690 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1346614007691 MarR family; Region: MarR_2; pfam12802 1346614007692 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 1346614007693 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614007694 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1346614007695 Coenzyme A binding pocket [chemical binding]; other site 1346614007696 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1346614007697 YheO-like PAS domain; Region: PAS_6; pfam08348 1346614007698 HTH domain; Region: HTH_22; pfam13309 1346614007699 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1346614007700 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1346614007701 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1346614007702 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1346614007703 NAD(P) binding site [chemical binding]; other site 1346614007704 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1346614007705 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1346614007706 acyl-activating enzyme (AAE) consensus motif; other site 1346614007707 putative AMP binding site [chemical binding]; other site 1346614007708 putative active site [active] 1346614007709 putative CoA binding site [chemical binding]; other site 1346614007710 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 1346614007711 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1346614007712 conserved cys residue [active] 1346614007713 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1346614007714 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1346614007715 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1346614007716 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1346614007717 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1346614007718 HlyD family secretion protein; Region: HlyD_3; pfam13437 1346614007719 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1346614007720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614007721 putative substrate translocation pore; other site 1346614007722 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614007723 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1346614007724 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1346614007725 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1346614007726 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1346614007727 active site 1346614007728 homotetramer interface [polypeptide binding]; other site 1346614007729 homodimer interface [polypeptide binding]; other site 1346614007730 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1346614007731 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 1346614007732 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614007733 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1346614007734 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1346614007735 dimerization interface [polypeptide binding]; other site 1346614007736 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1346614007737 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1346614007738 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 1346614007739 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1346614007740 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1346614007741 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1346614007742 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1346614007743 non-specific DNA binding site [nucleotide binding]; other site 1346614007744 salt bridge; other site 1346614007745 sequence-specific DNA binding site [nucleotide binding]; other site 1346614007746 Cupin domain; Region: Cupin_2; cl17218 1346614007747 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1346614007748 EamA-like transporter family; Region: EamA; pfam00892 1346614007749 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1346614007750 Cytochrome c; Region: Cytochrom_C; pfam00034 1346614007751 Cytochrome c; Region: Cytochrom_C; pfam00034 1346614007752 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1346614007753 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1346614007754 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1346614007755 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1346614007756 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1346614007757 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 1346614007758 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1346614007759 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1346614007760 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1346614007761 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1346614007762 putative ligand binding site [chemical binding]; other site 1346614007763 NAD binding site [chemical binding]; other site 1346614007764 catalytic site [active] 1346614007765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614007766 D-galactonate transporter; Region: 2A0114; TIGR00893 1346614007767 putative substrate translocation pore; other site 1346614007768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614007769 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1346614007770 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1346614007771 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1346614007772 putative active site [active] 1346614007773 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1346614007774 beta-galactosidase; Region: BGL; TIGR03356 1346614007775 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 1346614007776 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1346614007777 putative ligand binding site [chemical binding]; other site 1346614007778 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1346614007779 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1346614007780 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1346614007781 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1346614007782 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1346614007783 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1346614007784 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1346614007785 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1346614007786 ligand binding site [chemical binding]; other site 1346614007787 NAD binding site [chemical binding]; other site 1346614007788 dimerization interface [polypeptide binding]; other site 1346614007789 catalytic site [active] 1346614007790 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1346614007791 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1346614007792 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1346614007793 tetramerization interface [polypeptide binding]; other site 1346614007794 NAD(P) binding site [chemical binding]; other site 1346614007795 catalytic residues [active] 1346614007796 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1346614007797 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1346614007798 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1346614007799 putative active site [active] 1346614007800 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1346614007801 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1346614007802 dimer interface [polypeptide binding]; other site 1346614007803 PYR/PP interface [polypeptide binding]; other site 1346614007804 TPP binding site [chemical binding]; other site 1346614007805 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1346614007806 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1346614007807 TPP-binding site [chemical binding]; other site 1346614007808 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1346614007809 Eukaryotic protein of unknown function (DUF842); Region: DUF842; pfam05811 1346614007810 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1346614007811 short chain dehydrogenase; Provisional; Region: PRK06198 1346614007812 classical (c) SDRs; Region: SDR_c; cd05233 1346614007813 NAD(P) binding site [chemical binding]; other site 1346614007814 active site 1346614007815 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 1346614007816 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 1346614007817 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1346614007818 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 1346614007819 active site 1346614007820 catalytic residues [active] 1346614007821 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1346614007822 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1346614007823 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1346614007824 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1346614007825 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1346614007826 catalytic residue [active] 1346614007827 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1346614007828 dimer interface [polypeptide binding]; other site 1346614007829 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 1346614007830 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1346614007831 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1346614007832 metal binding site [ion binding]; metal-binding site 1346614007833 active site 1346614007834 I-site; other site 1346614007835 MASE1; Region: MASE1; cl17823 1346614007836 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1346614007837 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1346614007838 N-terminal plug; other site 1346614007839 ligand-binding site [chemical binding]; other site 1346614007840 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1346614007841 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1346614007842 Ca binding site [ion binding]; other site 1346614007843 active site 1346614007844 catalytic site [active] 1346614007845 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1346614007846 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1346614007847 Walker A/P-loop; other site 1346614007848 ATP binding site [chemical binding]; other site 1346614007849 Q-loop/lid; other site 1346614007850 ABC transporter signature motif; other site 1346614007851 Walker B; other site 1346614007852 D-loop; other site 1346614007853 H-loop/switch region; other site 1346614007854 TOBE domain; Region: TOBE_2; pfam08402 1346614007855 alpha-galactosidase; Provisional; Region: PRK15076 1346614007856 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1346614007857 NAD(P) binding site [chemical binding]; other site 1346614007858 LDH/MDH dimer interface [polypeptide binding]; other site 1346614007859 substrate binding site [chemical binding]; other site 1346614007860 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1346614007861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614007862 dimer interface [polypeptide binding]; other site 1346614007863 conserved gate region; other site 1346614007864 putative PBP binding loops; other site 1346614007865 ABC-ATPase subunit interface; other site 1346614007866 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614007867 dimer interface [polypeptide binding]; other site 1346614007868 conserved gate region; other site 1346614007869 putative PBP binding loops; other site 1346614007870 ABC-ATPase subunit interface; other site 1346614007871 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1346614007872 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1346614007873 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614007874 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614007875 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1346614007876 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1346614007877 active site turn [active] 1346614007878 phosphorylation site [posttranslational modification] 1346614007879 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 1346614007880 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1346614007881 dimerization interface [polypeptide binding]; other site 1346614007882 putative DNA binding site [nucleotide binding]; other site 1346614007883 putative Zn2+ binding site [ion binding]; other site 1346614007884 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1346614007885 active site residue [active] 1346614007886 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 1346614007887 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 1346614007888 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 1346614007889 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1346614007890 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1346614007891 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1346614007892 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1346614007893 Predicted acetyltransferase [General function prediction only]; Region: COG5628 1346614007894 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1346614007895 Cation efflux family; Region: Cation_efflux; cl00316 1346614007896 Cation efflux family; Region: Cation_efflux; cl00316 1346614007897 Cation efflux family; Region: Cation_efflux; cl00316 1346614007898 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1346614007899 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1346614007900 Divalent cation transporter; Region: MgtE; pfam01769 1346614007901 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1346614007902 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1346614007903 peptide binding site [polypeptide binding]; other site 1346614007904 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1346614007905 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1346614007906 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1346614007907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614007908 dimer interface [polypeptide binding]; other site 1346614007909 conserved gate region; other site 1346614007910 putative PBP binding loops; other site 1346614007911 ABC-ATPase subunit interface; other site 1346614007912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614007913 dimer interface [polypeptide binding]; other site 1346614007914 conserved gate region; other site 1346614007915 putative PBP binding loops; other site 1346614007916 ABC-ATPase subunit interface; other site 1346614007917 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1346614007918 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1346614007919 Walker A/P-loop; other site 1346614007920 ATP binding site [chemical binding]; other site 1346614007921 Q-loop/lid; other site 1346614007922 ABC transporter signature motif; other site 1346614007923 Walker B; other site 1346614007924 D-loop; other site 1346614007925 H-loop/switch region; other site 1346614007926 elongation factor G; Reviewed; Region: PRK00007 1346614007927 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1346614007928 G1 box; other site 1346614007929 putative GEF interaction site [polypeptide binding]; other site 1346614007930 GTP/Mg2+ binding site [chemical binding]; other site 1346614007931 Switch I region; other site 1346614007932 G2 box; other site 1346614007933 G3 box; other site 1346614007934 Switch II region; other site 1346614007935 G4 box; other site 1346614007936 G5 box; other site 1346614007937 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1346614007938 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1346614007939 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1346614007940 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1346614007941 EamA-like transporter family; Region: EamA; pfam00892 1346614007942 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1346614007943 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614007944 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1346614007945 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1346614007946 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1346614007947 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1346614007948 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1346614007949 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1346614007950 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1346614007951 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1346614007952 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1346614007953 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1346614007954 Cupin domain; Region: Cupin_2; pfam07883 1346614007955 K+ potassium transporter; Region: K_trans; pfam02705 1346614007956 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1346614007957 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614007958 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1346614007959 dimerization interface [polypeptide binding]; other site 1346614007960 substrate binding pocket [chemical binding]; other site 1346614007961 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1346614007962 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1346614007963 TM-ABC transporter signature motif; other site 1346614007964 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1346614007965 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1346614007966 TM-ABC transporter signature motif; other site 1346614007967 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1346614007968 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1346614007969 Walker A/P-loop; other site 1346614007970 ATP binding site [chemical binding]; other site 1346614007971 Q-loop/lid; other site 1346614007972 ABC transporter signature motif; other site 1346614007973 Walker B; other site 1346614007974 D-loop; other site 1346614007975 H-loop/switch region; other site 1346614007976 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1346614007977 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1346614007978 Walker A/P-loop; other site 1346614007979 ATP binding site [chemical binding]; other site 1346614007980 Q-loop/lid; other site 1346614007981 ABC transporter signature motif; other site 1346614007982 Walker B; other site 1346614007983 D-loop; other site 1346614007984 H-loop/switch region; other site 1346614007985 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1346614007986 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1346614007987 dimerization interface [polypeptide binding]; other site 1346614007988 ligand binding site [chemical binding]; other site 1346614007989 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 1346614007990 allantoate amidohydrolase; Reviewed; Region: PRK09290 1346614007991 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1346614007992 active site 1346614007993 metal binding site [ion binding]; metal-binding site 1346614007994 dimer interface [polypeptide binding]; other site 1346614007995 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1346614007996 dimerization interface [polypeptide binding]; other site 1346614007997 putative DNA binding site [nucleotide binding]; other site 1346614007998 putative Zn2+ binding site [ion binding]; other site 1346614007999 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1346614008000 putative hydrophobic ligand binding site [chemical binding]; other site 1346614008001 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1346614008002 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 1346614008003 Cl binding site [ion binding]; other site 1346614008004 oligomer interface [polypeptide binding]; other site 1346614008005 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1346614008006 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1346614008007 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1346614008008 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1346614008009 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1346614008010 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1346614008011 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1346614008012 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1346614008013 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1346614008014 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 1346614008015 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1346614008016 DNA-binding site [nucleotide binding]; DNA binding site 1346614008017 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1346614008018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614008019 homodimer interface [polypeptide binding]; other site 1346614008020 catalytic residue [active] 1346614008021 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1346614008022 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1346614008023 catalytic triad [active] 1346614008024 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1346614008025 dimer interface [polypeptide binding]; other site 1346614008026 pyridoxamine kinase; Validated; Region: PRK05756 1346614008027 pyridoxal binding site [chemical binding]; other site 1346614008028 ATP binding site [chemical binding]; other site 1346614008029 Flagellar regulator YcgR; Region: YcgR; pfam07317 1346614008030 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1346614008031 PilZ domain; Region: PilZ; pfam07238 1346614008032 N-formylglutamate amidohydrolase; Region: FGase; cl01522 1346614008033 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 1346614008034 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1346614008035 putative acyl-acceptor binding pocket; other site 1346614008036 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 1346614008037 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 1346614008038 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1346614008039 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1346614008040 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1346614008041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1346614008042 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614008043 ABC-ATPase subunit interface; other site 1346614008044 putative PBP binding loops; other site 1346614008045 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1346614008046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614008047 dimer interface [polypeptide binding]; other site 1346614008048 conserved gate region; other site 1346614008049 putative PBP binding loops; other site 1346614008050 ABC-ATPase subunit interface; other site 1346614008051 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1346614008052 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1346614008053 Walker A/P-loop; other site 1346614008054 ATP binding site [chemical binding]; other site 1346614008055 Q-loop/lid; other site 1346614008056 ABC transporter signature motif; other site 1346614008057 Walker B; other site 1346614008058 D-loop; other site 1346614008059 H-loop/switch region; other site 1346614008060 TOBE domain; Region: TOBE_2; pfam08402 1346614008061 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1346614008062 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1346614008063 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1346614008064 fructokinase; Reviewed; Region: PRK09557 1346614008065 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1346614008066 nucleotide binding site [chemical binding]; other site 1346614008067 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1346614008068 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1346614008069 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1346614008070 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 1346614008071 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1346614008072 dimer interface [polypeptide binding]; other site 1346614008073 active site 1346614008074 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 1346614008075 putative active site [active] 1346614008076 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1346614008077 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1346614008078 intersubunit interface [polypeptide binding]; other site 1346614008079 active site 1346614008080 zinc binding site [ion binding]; other site 1346614008081 Na+ binding site [ion binding]; other site 1346614008082 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 1346614008083 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1346614008084 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1346614008085 DNA binding site [nucleotide binding] 1346614008086 active site 1346614008087 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1346614008088 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1346614008089 ligand binding site [chemical binding]; other site 1346614008090 flexible hinge region; other site 1346614008091 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1346614008092 putative switch regulator; other site 1346614008093 non-specific DNA interactions [nucleotide binding]; other site 1346614008094 DNA binding site [nucleotide binding] 1346614008095 sequence specific DNA binding site [nucleotide binding]; other site 1346614008096 putative cAMP binding site [chemical binding]; other site 1346614008097 universal stress protein UspE; Provisional; Region: PRK11175 1346614008098 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1346614008099 Ligand Binding Site [chemical binding]; other site 1346614008100 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1346614008101 Ligand Binding Site [chemical binding]; other site 1346614008102 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 1346614008103 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1346614008104 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 1346614008105 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1346614008106 ligand binding site [chemical binding]; other site 1346614008107 homodimer interface [polypeptide binding]; other site 1346614008108 NAD(P) binding site [chemical binding]; other site 1346614008109 trimer interface B [polypeptide binding]; other site 1346614008110 trimer interface A [polypeptide binding]; other site 1346614008111 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1346614008112 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1346614008113 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1346614008114 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1346614008115 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1346614008116 dihydromonapterin reductase; Provisional; Region: PRK06483 1346614008117 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1346614008118 NAD(P) binding site [chemical binding]; other site 1346614008119 active site 1346614008120 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 1346614008121 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614008122 active site 1346614008123 phosphorylation site [posttranslational modification] 1346614008124 intermolecular recognition site; other site 1346614008125 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1346614008126 DNA binding site [nucleotide binding] 1346614008127 sensor protein RstB; Provisional; Region: PRK10604 1346614008128 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1346614008129 dimerization interface [polypeptide binding]; other site 1346614008130 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1346614008131 dimer interface [polypeptide binding]; other site 1346614008132 phosphorylation site [posttranslational modification] 1346614008133 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614008134 ATP binding site [chemical binding]; other site 1346614008135 Mg2+ binding site [ion binding]; other site 1346614008136 G-X-G motif; other site 1346614008137 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1346614008138 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1346614008139 active site 1346614008140 Zn binding site [ion binding]; other site 1346614008141 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1346614008142 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1346614008143 Helix-turn-helix domain; Region: HTH_18; pfam12833 1346614008144 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614008145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614008146 putative substrate translocation pore; other site 1346614008147 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1346614008148 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1346614008149 ATP binding site [chemical binding]; other site 1346614008150 putative Mg++ binding site [ion binding]; other site 1346614008151 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1346614008152 nucleotide binding region [chemical binding]; other site 1346614008153 ATP-binding site [chemical binding]; other site 1346614008154 Helicase associated domain (HA2); Region: HA2; pfam04408 1346614008155 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1346614008156 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1346614008157 azoreductase; Reviewed; Region: PRK00170 1346614008158 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1346614008159 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 1346614008160 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 1346614008161 hypothetical protein; Provisional; Region: PRK10695 1346614008162 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1346614008163 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 1346614008164 putative ligand binding site [chemical binding]; other site 1346614008165 putative NAD binding site [chemical binding]; other site 1346614008166 catalytic site [active] 1346614008167 heat-inducible protein; Provisional; Region: PRK10449 1346614008168 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1346614008169 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1346614008170 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1346614008171 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1346614008172 dimer interface [polypeptide binding]; other site 1346614008173 PYR/PP interface [polypeptide binding]; other site 1346614008174 TPP binding site [chemical binding]; other site 1346614008175 substrate binding site [chemical binding]; other site 1346614008176 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1346614008177 Domain of unknown function; Region: EKR; pfam10371 1346614008178 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1346614008179 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1346614008180 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1346614008181 TPP-binding site [chemical binding]; other site 1346614008182 dimer interface [polypeptide binding]; other site 1346614008183 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1346614008184 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1346614008185 HlyD family secretion protein; Region: HlyD_3; pfam13437 1346614008186 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1346614008187 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1346614008188 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1346614008189 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1346614008190 metal-binding site [ion binding] 1346614008191 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1346614008192 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1346614008193 metal-binding site [ion binding] 1346614008194 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1346614008195 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1346614008196 motif II; other site 1346614008197 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1346614008198 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1346614008199 DNA binding residues [nucleotide binding] 1346614008200 dimer interface [polypeptide binding]; other site 1346614008201 copper binding site [ion binding]; other site 1346614008202 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1346614008203 metal-binding site [ion binding] 1346614008204 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1346614008205 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1346614008206 Ligand Binding Site [chemical binding]; other site 1346614008207 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1346614008208 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1346614008209 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1346614008210 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 1346614008211 Cl binding site [ion binding]; other site 1346614008212 oligomer interface [polypeptide binding]; other site 1346614008213 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1346614008214 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1346614008215 peptide binding site [polypeptide binding]; other site 1346614008216 murein peptide amidase A; Provisional; Region: PRK10602 1346614008217 active site 1346614008218 Zn binding site [ion binding]; other site 1346614008219 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 1346614008220 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1346614008221 active site 1346614008222 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1346614008223 dimer interface [polypeptide binding]; other site 1346614008224 catalytic triad [active] 1346614008225 peroxidatic and resolving cysteines [active] 1346614008226 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 1346614008227 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 1346614008228 putative aromatic amino acid binding site; other site 1346614008229 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1346614008230 putative active site [active] 1346614008231 heme pocket [chemical binding]; other site 1346614008232 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1346614008233 Walker A motif; other site 1346614008234 ATP binding site [chemical binding]; other site 1346614008235 Walker B motif; other site 1346614008236 arginine finger; other site 1346614008237 hypothetical protein; Provisional; Region: PRK05415 1346614008238 Domain of unknown function (DUF697); Region: DUF697; cl12064 1346614008239 Predicted ATPase [General function prediction only]; Region: COG3106 1346614008240 Phage shock protein PspD (Phageshock_PspD); Region: Phageshock_PspD; pfam09584 1346614008241 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 1346614008242 phage shock protein C; Region: phageshock_pspC; TIGR02978 1346614008243 phage shock protein B; Provisional; Region: pspB; PRK09458 1346614008244 phage shock protein PspA; Provisional; Region: PRK10698 1346614008245 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 1346614008246 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1346614008247 Walker A motif; other site 1346614008248 ATP binding site [chemical binding]; other site 1346614008249 Walker B motif; other site 1346614008250 arginine finger; other site 1346614008251 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1346614008252 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1346614008253 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1346614008254 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1346614008255 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1346614008256 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 1346614008257 trimer interface [polypeptide binding]; other site 1346614008258 active site 1346614008259 putative GTP cyclohydrolase; Provisional; Region: PRK13674 1346614008260 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1346614008261 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1346614008262 peptide binding site [polypeptide binding]; other site 1346614008263 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 1346614008264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614008265 dimer interface [polypeptide binding]; other site 1346614008266 conserved gate region; other site 1346614008267 putative PBP binding loops; other site 1346614008268 ABC-ATPase subunit interface; other site 1346614008269 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 1346614008270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614008271 dimer interface [polypeptide binding]; other site 1346614008272 conserved gate region; other site 1346614008273 putative PBP binding loops; other site 1346614008274 ABC-ATPase subunit interface; other site 1346614008275 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 1346614008276 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1346614008277 Walker A/P-loop; other site 1346614008278 ATP binding site [chemical binding]; other site 1346614008279 Q-loop/lid; other site 1346614008280 ABC transporter signature motif; other site 1346614008281 Walker B; other site 1346614008282 D-loop; other site 1346614008283 H-loop/switch region; other site 1346614008284 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1346614008285 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 1346614008286 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1346614008287 Walker A/P-loop; other site 1346614008288 ATP binding site [chemical binding]; other site 1346614008289 Q-loop/lid; other site 1346614008290 ABC transporter signature motif; other site 1346614008291 Walker B; other site 1346614008292 D-loop; other site 1346614008293 H-loop/switch region; other site 1346614008294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 1346614008295 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1346614008296 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1346614008297 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614008298 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614008299 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1346614008300 dimerization interface [polypeptide binding]; other site 1346614008301 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1346614008302 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 1346614008303 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1346614008304 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1346614008305 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1346614008306 putative molybdopterin cofactor binding site [chemical binding]; other site 1346614008307 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1346614008308 putative molybdopterin cofactor binding site; other site 1346614008309 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614008310 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614008311 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1346614008312 dimerization interface [polypeptide binding]; other site 1346614008313 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1346614008314 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1346614008315 dimer interface [polypeptide binding]; other site 1346614008316 active site 1346614008317 metal binding site [ion binding]; metal-binding site 1346614008318 glutathione binding site [chemical binding]; other site 1346614008319 exoribonuclease II; Provisional; Region: PRK05054 1346614008320 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1346614008321 RNB domain; Region: RNB; pfam00773 1346614008322 S1 RNA binding domain; Region: S1; pfam00575 1346614008323 carbon starvation protein A; Provisional; Region: PRK15015 1346614008324 Carbon starvation protein CstA; Region: CstA; pfam02554 1346614008325 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1346614008326 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1346614008327 active site 1346614008328 intersubunit interactions; other site 1346614008329 catalytic residue [active] 1346614008330 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 1346614008331 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1346614008332 FeS/SAM binding site; other site 1346614008333 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 1346614008334 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1346614008335 dimer interface [polypeptide binding]; other site 1346614008336 active site 1346614008337 glycine loop; other site 1346614008338 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1346614008339 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1346614008340 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1346614008341 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1346614008342 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1346614008343 intersubunit interface [polypeptide binding]; other site 1346614008344 active site 1346614008345 Zn2+ binding site [ion binding]; other site 1346614008346 lipoprotein; Provisional; Region: PRK10540 1346614008347 translation initiation factor Sui1; Validated; Region: PRK06824 1346614008348 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1346614008349 putative rRNA binding site [nucleotide binding]; other site 1346614008350 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1346614008351 active site 1346614008352 dimer interface [polypeptide binding]; other site 1346614008353 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 1346614008354 Arc-like DNA binding domain; Region: Arc; pfam03869 1346614008355 tetratricopeptide repeat protein; Provisional; Region: PRK11788 1346614008356 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1346614008357 TPR motif; other site 1346614008358 binding surface 1346614008359 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1346614008360 binding surface 1346614008361 TPR motif; other site 1346614008362 Predicted membrane protein [Function unknown]; Region: COG3771 1346614008363 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1346614008364 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1346614008365 active site 1346614008366 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1346614008367 dimerization interface [polypeptide binding]; other site 1346614008368 active site 1346614008369 aconitate hydratase; Validated; Region: PRK09277 1346614008370 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1346614008371 substrate binding site [chemical binding]; other site 1346614008372 ligand binding site [chemical binding]; other site 1346614008373 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1346614008374 substrate binding site [chemical binding]; other site 1346614008375 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 1346614008376 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614008377 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 1346614008378 substrate binding site [chemical binding]; other site 1346614008379 putative dimerization interface [polypeptide binding]; other site 1346614008380 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1346614008381 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1346614008382 active site 1346614008383 interdomain interaction site; other site 1346614008384 putative metal-binding site [ion binding]; other site 1346614008385 nucleotide binding site [chemical binding]; other site 1346614008386 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1346614008387 domain I; other site 1346614008388 DNA binding groove [nucleotide binding] 1346614008389 phosphate binding site [ion binding]; other site 1346614008390 domain II; other site 1346614008391 domain III; other site 1346614008392 nucleotide binding site [chemical binding]; other site 1346614008393 catalytic site [active] 1346614008394 domain IV; other site 1346614008395 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1346614008396 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1346614008397 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1346614008398 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1346614008399 hypothetical protein; Provisional; Region: PRK11037 1346614008400 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 1346614008401 putative inner membrane peptidase; Provisional; Region: PRK11778 1346614008402 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1346614008403 tandem repeat interface [polypeptide binding]; other site 1346614008404 oligomer interface [polypeptide binding]; other site 1346614008405 active site residues [active] 1346614008406 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 1346614008407 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 1346614008408 NADP binding site [chemical binding]; other site 1346614008409 homodimer interface [polypeptide binding]; other site 1346614008410 active site 1346614008411 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1346614008412 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 1346614008413 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1346614008414 homodimer interface [polypeptide binding]; other site 1346614008415 Walker A motif; other site 1346614008416 ATP binding site [chemical binding]; other site 1346614008417 hydroxycobalamin binding site [chemical binding]; other site 1346614008418 Walker B motif; other site 1346614008419 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 1346614008420 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1346614008421 RNA binding surface [nucleotide binding]; other site 1346614008422 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1346614008423 probable active site [active] 1346614008424 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1346614008425 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1346614008426 active site 1346614008427 Int/Topo IB signature motif; other site 1346614008428 DNA binding site [nucleotide binding] 1346614008429 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1346614008430 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1346614008431 catalytic residues [active] 1346614008432 catalytic nucleophile [active] 1346614008433 Presynaptic Site I dimer interface [polypeptide binding]; other site 1346614008434 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1346614008435 Synaptic Flat tetramer interface [polypeptide binding]; other site 1346614008436 Synaptic Site I dimer interface [polypeptide binding]; other site 1346614008437 DNA binding site [nucleotide binding] 1346614008438 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1346614008439 DNA-binding interface [nucleotide binding]; DNA binding site 1346614008440 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1346614008441 hypothetical protein; Provisional; Region: PRK11630 1346614008442 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1346614008443 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1346614008444 active site 1346614008445 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1346614008446 anthranilate synthase component I; Provisional; Region: PRK13564 1346614008447 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1346614008448 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1346614008449 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1346614008450 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1346614008451 glutamine binding [chemical binding]; other site 1346614008452 catalytic triad [active] 1346614008453 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1346614008454 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1346614008455 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1346614008456 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1346614008457 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1346614008458 active site 1346614008459 ribulose/triose binding site [chemical binding]; other site 1346614008460 phosphate binding site [ion binding]; other site 1346614008461 substrate (anthranilate) binding pocket [chemical binding]; other site 1346614008462 product (indole) binding pocket [chemical binding]; other site 1346614008463 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1346614008464 active site 1346614008465 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1346614008466 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1346614008467 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614008468 catalytic residue [active] 1346614008469 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1346614008470 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1346614008471 substrate binding site [chemical binding]; other site 1346614008472 active site 1346614008473 catalytic residues [active] 1346614008474 heterodimer interface [polypeptide binding]; other site 1346614008475 BON domain; Region: BON; pfam04972 1346614008476 outer membrane protein W; Provisional; Region: PRK10959 1346614008477 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 1346614008478 hypothetical protein; Provisional; Region: PRK02868 1346614008479 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1346614008480 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1346614008481 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1346614008482 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1346614008483 intracellular septation protein A; Reviewed; Region: PRK00259 1346614008484 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1346614008485 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1346614008486 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1346614008487 DNA binding site [nucleotide binding] 1346614008488 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1346614008489 ligand binding site [chemical binding]; other site 1346614008490 dimerization interface [polypeptide binding]; other site 1346614008491 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 1346614008492 active site 1346614008493 putative transporter; Provisional; Region: PRK03699 1346614008494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614008495 putative substrate translocation pore; other site 1346614008496 transport protein TonB; Provisional; Region: PRK10819 1346614008497 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1346614008498 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 1346614008499 YciI-like protein; Reviewed; Region: PRK11370 1346614008500 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1346614008501 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 1346614008502 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1346614008503 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1346614008504 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1346614008505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614008506 putative substrate translocation pore; other site 1346614008507 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1346614008508 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1346614008509 dimerization interface [polypeptide binding]; other site 1346614008510 DPS ferroxidase diiron center [ion binding]; other site 1346614008511 ion pore; other site 1346614008512 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1346614008513 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1346614008514 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 1346614008515 putative active site [active] 1346614008516 catalytic site [active] 1346614008517 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 1346614008518 putative active site [active] 1346614008519 catalytic site [active] 1346614008520 dsDNA-mimic protein; Reviewed; Region: PRK05094 1346614008521 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1346614008522 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1346614008523 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1346614008524 glycerol kinase; Region: glycerol_kin; TIGR01311 1346614008525 Proteobacterial glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK_like_proteobact; cd07794 1346614008526 N- and C-terminal domain interface [polypeptide binding]; other site 1346614008527 putative homotetramer interface [polypeptide binding]; other site 1346614008528 putative homodimer interface [polypeptide binding]; other site 1346614008529 active site 1346614008530 putative glycerol binding site [chemical binding]; other site 1346614008531 MgATP binding site [chemical binding]; other site 1346614008532 ethanolamine utilization protein EutH; Provisional; Region: PRK15086 1346614008533 Domain of unknown function (DUF1937); Region: DUF1937; pfam09152 1346614008534 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1346614008535 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1346614008536 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1346614008537 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1346614008538 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1346614008539 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1346614008540 Walker A/P-loop; other site 1346614008541 ATP binding site [chemical binding]; other site 1346614008542 Q-loop/lid; other site 1346614008543 ABC transporter signature motif; other site 1346614008544 Walker B; other site 1346614008545 D-loop; other site 1346614008546 H-loop/switch region; other site 1346614008547 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1346614008548 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 1346614008549 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1346614008550 Walker A/P-loop; other site 1346614008551 ATP binding site [chemical binding]; other site 1346614008552 Q-loop/lid; other site 1346614008553 ABC transporter signature motif; other site 1346614008554 Walker B; other site 1346614008555 D-loop; other site 1346614008556 H-loop/switch region; other site 1346614008557 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1346614008558 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1346614008559 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1346614008560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614008561 dimer interface [polypeptide binding]; other site 1346614008562 conserved gate region; other site 1346614008563 ABC-ATPase subunit interface; other site 1346614008564 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1346614008565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614008566 dimer interface [polypeptide binding]; other site 1346614008567 conserved gate region; other site 1346614008568 putative PBP binding loops; other site 1346614008569 ABC-ATPase subunit interface; other site 1346614008570 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1346614008571 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1346614008572 peptide binding site [polypeptide binding]; other site 1346614008573 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1346614008574 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1346614008575 peptide binding site [polypeptide binding]; other site 1346614008576 hypothetical protein; Provisional; Region: PRK11111 1346614008577 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1346614008578 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1346614008579 putative catalytic cysteine [active] 1346614008580 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1346614008581 putative active site [active] 1346614008582 metal binding site [ion binding]; metal-binding site 1346614008583 thymidine kinase; Provisional; Region: PRK04296 1346614008584 Uncharacterized conserved protein (DUF2217); Region: DUF2217; pfam10265 1346614008585 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 1346614008586 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1346614008587 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1346614008588 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1346614008589 putative NAD(P) binding site [chemical binding]; other site 1346614008590 active site 1346614008591 putative substrate binding site [chemical binding]; other site 1346614008592 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1346614008593 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1346614008594 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1346614008595 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1346614008596 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1346614008597 tetramer interface; other site 1346614008598 active site 1346614008599 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614008600 active site 1346614008601 response regulator of RpoS; Provisional; Region: PRK10693 1346614008602 phosphorylation site [posttranslational modification] 1346614008603 intermolecular recognition site; other site 1346614008604 dimerization interface [polypeptide binding]; other site 1346614008605 hypothetical protein; Provisional; Region: PRK10279 1346614008606 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1346614008607 active site 1346614008608 nucleophile elbow; other site 1346614008609 hypothetical protein; Provisional; Region: PRK01617 1346614008610 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1346614008611 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1346614008612 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1346614008613 putative active site [active] 1346614008614 putative substrate binding site [chemical binding]; other site 1346614008615 putative cosubstrate binding site; other site 1346614008616 catalytic site [active] 1346614008617 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1346614008618 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1346614008619 putative catalytic site [active] 1346614008620 putative phosphate binding site [ion binding]; other site 1346614008621 active site 1346614008622 metal binding site A [ion binding]; metal-binding site 1346614008623 DNA binding site [nucleotide binding] 1346614008624 putative AP binding site [nucleotide binding]; other site 1346614008625 putative metal binding site B [ion binding]; other site 1346614008626 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1346614008627 active site 1346614008628 8-oxo-dGMP binding site [chemical binding]; other site 1346614008629 nudix motif; other site 1346614008630 metal binding site [ion binding]; metal-binding site 1346614008631 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 1346614008632 DNA topoisomerase III; Provisional; Region: PRK07726 1346614008633 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1346614008634 active site 1346614008635 putative interdomain interaction site [polypeptide binding]; other site 1346614008636 putative metal-binding site [ion binding]; other site 1346614008637 putative nucleotide binding site [chemical binding]; other site 1346614008638 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1346614008639 domain I; other site 1346614008640 DNA binding groove [nucleotide binding] 1346614008641 phosphate binding site [ion binding]; other site 1346614008642 domain II; other site 1346614008643 domain III; other site 1346614008644 nucleotide binding site [chemical binding]; other site 1346614008645 catalytic site [active] 1346614008646 domain IV; other site 1346614008647 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 1346614008648 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 1346614008649 active site residue [active] 1346614008650 selenophosphate synthetase; Provisional; Region: PRK00943 1346614008651 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1346614008652 dimerization interface [polypeptide binding]; other site 1346614008653 putative ATP binding site [chemical binding]; other site 1346614008654 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1346614008655 putative FMN binding site [chemical binding]; other site 1346614008656 protease 4; Provisional; Region: PRK10949 1346614008657 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1346614008658 tandem repeat interface [polypeptide binding]; other site 1346614008659 oligomer interface [polypeptide binding]; other site 1346614008660 active site residues [active] 1346614008661 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1346614008662 tandem repeat interface [polypeptide binding]; other site 1346614008663 oligomer interface [polypeptide binding]; other site 1346614008664 active site residues [active] 1346614008665 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1346614008666 active site 1346614008667 homodimer interface [polypeptide binding]; other site 1346614008668 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1346614008669 Isochorismatase family; Region: Isochorismatase; pfam00857 1346614008670 catalytic triad [active] 1346614008671 metal binding site [ion binding]; metal-binding site 1346614008672 conserved cis-peptide bond; other site 1346614008673 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1346614008674 Glyco_18 domain; Region: Glyco_18; smart00636 1346614008675 active site 1346614008676 Protein of unknown function (DUF1315); Region: DUF1315; cl01215 1346614008677 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1346614008678 SelR domain; Region: SelR; pfam01641 1346614008679 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 1346614008680 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1346614008681 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1346614008682 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1346614008683 active site 1346614008684 phosphate binding residues; other site 1346614008685 catalytic residues [active] 1346614008686 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1346614008687 PrkA family serine protein kinase; Provisional; Region: PRK15455 1346614008688 AAA ATPase domain; Region: AAA_16; pfam13191 1346614008689 Walker A motif; other site 1346614008690 ATP binding site [chemical binding]; other site 1346614008691 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1346614008692 hypothetical protein; Provisional; Region: PRK05325 1346614008693 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1346614008694 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 1346614008695 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1346614008696 conserved cys residue [active] 1346614008697 Serine hydrolase; Region: Ser_hydrolase; cl17834 1346614008698 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1346614008699 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 1346614008700 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 1346614008701 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1346614008702 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1346614008703 N-terminal plug; other site 1346614008704 ligand-binding site [chemical binding]; other site 1346614008705 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1346614008706 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1346614008707 Walker A/P-loop; other site 1346614008708 ATP binding site [chemical binding]; other site 1346614008709 Q-loop/lid; other site 1346614008710 ABC transporter signature motif; other site 1346614008711 Walker B; other site 1346614008712 D-loop; other site 1346614008713 H-loop/switch region; other site 1346614008714 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1346614008715 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1346614008716 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1346614008717 Walker A/P-loop; other site 1346614008718 ATP binding site [chemical binding]; other site 1346614008719 Q-loop/lid; other site 1346614008720 ABC transporter signature motif; other site 1346614008721 Walker B; other site 1346614008722 D-loop; other site 1346614008723 H-loop/switch region; other site 1346614008724 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1346614008725 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1346614008726 nickel ABC transporter, permease subunit NikB; Region: nickel_nikB; TIGR02789 1346614008727 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1346614008728 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1346614008729 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1346614008730 active site 1346614008731 substrate binding site [chemical binding]; other site 1346614008732 catalytic site [active] 1346614008733 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614008734 putative substrate translocation pore; other site 1346614008735 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1346614008736 alanine racemase; Reviewed; Region: dadX; PRK03646 1346614008737 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1346614008738 active site 1346614008739 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1346614008740 substrate binding site [chemical binding]; other site 1346614008741 catalytic residues [active] 1346614008742 dimer interface [polypeptide binding]; other site 1346614008743 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1346614008744 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1346614008745 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1346614008746 SpoVR family protein; Provisional; Region: PRK11767 1346614008747 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1346614008748 fatty acid metabolism regulator; Provisional; Region: PRK04984 1346614008749 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1346614008750 DNA-binding site [nucleotide binding]; DNA binding site 1346614008751 FadR C-terminal domain; Region: FadR_C; pfam07840 1346614008752 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 1346614008753 disulfide bond formation protein B; Provisional; Region: PRK01749 1346614008754 hypothetical protein; Provisional; Region: PRK05170 1346614008755 CsbD-like; Region: CsbD; cl17424 1346614008756 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1346614008757 hypothetical protein; Provisional; Region: PRK10691 1346614008758 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1346614008759 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1346614008760 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1346614008761 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 1346614008762 septum formation inhibitor; Reviewed; Region: minC; PRK03511 1346614008763 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1346614008764 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1346614008765 cell division inhibitor MinD; Provisional; Region: PRK10818 1346614008766 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1346614008767 Switch I; other site 1346614008768 Switch II; other site 1346614008769 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1346614008770 ribonuclease D; Provisional; Region: PRK10829 1346614008771 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1346614008772 catalytic site [active] 1346614008773 putative active site [active] 1346614008774 putative substrate binding site [chemical binding]; other site 1346614008775 HRDC domain; Region: HRDC; pfam00570 1346614008776 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 1346614008777 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1346614008778 acyl-activating enzyme (AAE) consensus motif; other site 1346614008779 putative AMP binding site [chemical binding]; other site 1346614008780 putative active site [active] 1346614008781 putative CoA binding site [chemical binding]; other site 1346614008782 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 1346614008783 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1346614008784 Glycoprotease family; Region: Peptidase_M22; pfam00814 1346614008785 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1346614008786 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1346614008787 ATP binding site [chemical binding]; other site 1346614008788 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1346614008789 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 1346614008790 homotrimer interaction site [polypeptide binding]; other site 1346614008791 putative active site [active] 1346614008792 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 1346614008793 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 1346614008794 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1346614008795 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1346614008796 active site 1346614008797 intersubunit interface [polypeptide binding]; other site 1346614008798 catalytic residue [active] 1346614008799 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1346614008800 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1346614008801 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1346614008802 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1346614008803 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1346614008804 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1346614008805 putative active site [active] 1346614008806 pyruvate kinase; Provisional; Region: PRK05826 1346614008807 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1346614008808 domain interfaces; other site 1346614008809 active site 1346614008810 Leucine rich repeat; Region: LRR_8; pfam13855 1346614008811 Leucine rich repeat; Region: LRR_8; pfam13855 1346614008812 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1346614008813 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1346614008814 putative acyl-acceptor binding pocket; other site 1346614008815 putative peptidase; Provisional; Region: PRK11649 1346614008816 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1346614008817 Peptidase family M23; Region: Peptidase_M23; pfam01551 1346614008818 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 1346614008819 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1346614008820 metal binding site [ion binding]; metal-binding site 1346614008821 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 1346614008822 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1346614008823 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1346614008824 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1346614008825 ABC-ATPase subunit interface; other site 1346614008826 dimer interface [polypeptide binding]; other site 1346614008827 putative PBP binding regions; other site 1346614008828 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1346614008829 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1346614008830 Walker A motif; other site 1346614008831 ATP binding site [chemical binding]; other site 1346614008832 Walker B motif; other site 1346614008833 arginine finger; other site 1346614008834 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1346614008835 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1346614008836 RuvA N terminal domain; Region: RuvA_N; pfam01330 1346614008837 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1346614008838 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1346614008839 active site 1346614008840 putative DNA-binding cleft [nucleotide binding]; other site 1346614008841 dimer interface [polypeptide binding]; other site 1346614008842 hypothetical protein; Validated; Region: PRK00110 1346614008843 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 1346614008844 nudix motif; other site 1346614008845 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1346614008846 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1346614008847 dimer interface [polypeptide binding]; other site 1346614008848 anticodon binding site; other site 1346614008849 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1346614008850 homodimer interface [polypeptide binding]; other site 1346614008851 motif 1; other site 1346614008852 active site 1346614008853 motif 2; other site 1346614008854 GAD domain; Region: GAD; pfam02938 1346614008855 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1346614008856 active site 1346614008857 motif 3; other site 1346614008858 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 1346614008859 Isochorismatase family; Region: Isochorismatase; pfam00857 1346614008860 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1346614008861 catalytic triad [active] 1346614008862 conserved cis-peptide bond; other site 1346614008863 hypothetical protein; Provisional; Region: PRK10302 1346614008864 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 1346614008865 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614008866 S-adenosylmethionine binding site [chemical binding]; other site 1346614008867 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614008868 S-adenosylmethionine binding site [chemical binding]; other site 1346614008869 copper homeostasis protein CutC; Provisional; Region: PRK11572 1346614008870 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 1346614008871 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1346614008872 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614008873 homodimer interface [polypeptide binding]; other site 1346614008874 catalytic residue [active] 1346614008875 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 1346614008876 putative metal binding site [ion binding]; other site 1346614008877 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1346614008878 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1346614008879 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1346614008880 active site 1346614008881 HIGH motif; other site 1346614008882 KMSK motif region; other site 1346614008883 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1346614008884 tRNA binding surface [nucleotide binding]; other site 1346614008885 anticodon binding site; other site 1346614008886 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1346614008887 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1346614008888 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1346614008889 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1346614008890 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 1346614008891 hypothetical protein; Provisional; Region: PRK11239 1346614008892 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 1346614008893 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1346614008894 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1346614008895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614008896 putative substrate translocation pore; other site 1346614008897 glutaredoxin 2; Provisional; Region: PRK10387 1346614008898 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 1346614008899 C-terminal domain interface [polypeptide binding]; other site 1346614008900 GSH binding site (G-site) [chemical binding]; other site 1346614008901 catalytic residues [active] 1346614008902 putative dimer interface [polypeptide binding]; other site 1346614008903 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 1346614008904 N-terminal domain interface [polypeptide binding]; other site 1346614008905 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1346614008906 ABC1 family; Region: ABC1; pfam03109 1346614008907 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1346614008908 active site 1346614008909 ATP binding site [chemical binding]; other site 1346614008910 lipoprotein; Provisional; Region: PRK10598 1346614008911 hypothetical protein; Provisional; Region: PRK13680 1346614008912 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 1346614008913 YebG protein; Region: YebG; pfam07130 1346614008914 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1346614008915 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1346614008916 ATP binding site [chemical binding]; other site 1346614008917 Mg++ binding site [ion binding]; other site 1346614008918 motif III; other site 1346614008919 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1346614008920 nucleotide binding region [chemical binding]; other site 1346614008921 ATP-binding site [chemical binding]; other site 1346614008922 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1346614008923 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1346614008924 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1346614008925 ATP-grasp domain; Region: ATP-grasp; pfam02222 1346614008926 hypothetical protein; Provisional; Region: PRK05114 1346614008927 putative glycosyl transferase; Provisional; Region: PRK10073 1346614008928 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1346614008929 active site 1346614008930 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 1346614008931 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1346614008932 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1346614008933 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1346614008934 putative active site [active] 1346614008935 putative CoA binding site [chemical binding]; other site 1346614008936 nudix motif; other site 1346614008937 metal binding site [ion binding]; metal-binding site 1346614008938 L-serine deaminase; Provisional; Region: PRK15023 1346614008939 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1346614008940 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1346614008941 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1346614008942 phage resistance protein; Provisional; Region: PRK10551 1346614008943 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1346614008944 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1346614008945 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1346614008946 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1346614008947 Transporter associated domain; Region: CorC_HlyC; smart01091 1346614008948 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1346614008949 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1346614008950 active pocket/dimerization site; other site 1346614008951 active site 1346614008952 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1346614008953 active site 1346614008954 phosphorylation site [posttranslational modification] 1346614008955 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1346614008956 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 1346614008957 hypothetical protein; Provisional; Region: PRK02913 1346614008958 hypothetical protein; Provisional; Region: PRK11469 1346614008959 Domain of unknown function DUF; Region: DUF204; pfam02659 1346614008960 Domain of unknown function DUF; Region: DUF204; pfam02659 1346614008961 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1346614008962 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1346614008963 S-adenosylmethionine binding site [chemical binding]; other site 1346614008964 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1346614008965 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1346614008966 DNA-binding site [nucleotide binding]; DNA binding site 1346614008967 RNA-binding motif; other site 1346614008968 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1346614008969 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1346614008970 aromatic amino acid transporter; Provisional; Region: PRK10238 1346614008971 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 1346614008972 Protein of unknown function (DUF2591); Region: DUF2591; pfam10765 1346614008973 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 1346614008974 FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244 1346614008975 dimer interface [polypeptide binding]; other site 1346614008976 Mn binding site [ion binding]; other site 1346614008977 K binding site [ion binding]; other site 1346614008978 YebO-like protein; Region: YebO; pfam13974 1346614008979 YobH-like protein; Region: YobH; pfam13996 1346614008980 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 1346614008981 YccJ-like protein; Region: YccJ; pfam13993 1346614008982 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1346614008983 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614008984 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1346614008985 Pirin; Region: Pirin; pfam02678 1346614008986 Pirin-related protein [General function prediction only]; Region: COG1741 1346614008987 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1346614008988 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1346614008989 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1346614008990 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 1346614008991 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 1346614008992 virion protein; Provisional; Region: V; PHA02564 1346614008993 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 1346614008994 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 1346614008995 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 1346614008996 Uncharacterized protein, homolog of phage Mu protein gp30 [Function unknown]; Region: COG2369 1346614008997 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1346614008998 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 1346614008999 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 1346614009000 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 1346614009001 Terminase-like family; Region: Terminase_6; pfam03237 1346614009002 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 1346614009003 Terminase small subunit; Region: Terminase_2; pfam03592 1346614009004 Head fiber protein; Region: Phage_head_fibr; pfam11133 1346614009005 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1346614009006 catalytic residues [active] 1346614009007 Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106 1346614009008 HNH endonuclease; Region: HNH_3; pfam13392 1346614009009 putative NHN endonuclease; Region: PHA00280 1346614009010 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 1346614009011 threonine synthase; Validated; Region: PRK06260 1346614009012 Protein of unknown function (DUF2591); Region: DUF2591; cl11584 1346614009013 NINE Protein; Region: NinE; pfam05322 1346614009014 NinB protein; Region: NinB; pfam05772 1346614009015 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1346614009016 phage replicative helicase, DnaB family, HK022 subfamily; Region: phage_DnaB; TIGR03600 1346614009017 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1346614009018 Walker A motif; other site 1346614009019 ATP binding site [chemical binding]; other site 1346614009020 Walker B motif; other site 1346614009021 HNH endonuclease; Region: HNH_3; pfam13392 1346614009022 Bacteriophage CII protein; Region: Phage_CII; pfam05269 1346614009023 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1346614009024 sequence-specific DNA binding site [nucleotide binding]; other site 1346614009025 salt bridge; other site 1346614009026 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1346614009027 non-specific DNA binding site [nucleotide binding]; other site 1346614009028 Predicted transcriptional regulator [Transcription]; Region: COG2932 1346614009029 salt bridge; other site 1346614009030 sequence-specific DNA binding site [nucleotide binding]; other site 1346614009031 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1346614009032 Catalytic site [active] 1346614009033 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1346614009034 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1346614009035 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1346614009036 Lambda Phage CIII; Region: Lambda_CIII; pfam02061 1346614009037 ERF superfamily; Region: ERF; pfam04404 1346614009038 Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354 1346614009039 DNA polymerase III, theta subunit; Region: DNA_pol3_theta; pfam06440 1346614009040 hypothetical protein; Region: PHA00781 1346614009041 integrase; Provisional; Region: PRK09692 1346614009042 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1346614009043 active site 1346614009044 Int/Topo IB signature motif; other site 1346614009045 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1346614009046 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1346614009047 trimer interface [polypeptide binding]; other site 1346614009048 eyelet of channel; other site 1346614009049 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 1346614009050 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1346614009051 putative active site [active] 1346614009052 Zn binding site [ion binding]; other site 1346614009053 succinylarginine dihydrolase; Provisional; Region: PRK13281 1346614009054 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 1346614009055 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 1346614009056 NAD(P) binding site [chemical binding]; other site 1346614009057 catalytic residues [active] 1346614009058 arginine succinyltransferase; Provisional; Region: PRK10456 1346614009059 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1346614009060 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 1346614009061 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1346614009062 inhibitor-cofactor binding pocket; inhibition site 1346614009063 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614009064 catalytic residue [active] 1346614009065 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1346614009066 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1346614009067 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1346614009068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614009069 dimer interface [polypeptide binding]; other site 1346614009070 conserved gate region; other site 1346614009071 putative PBP binding loops; other site 1346614009072 ABC-ATPase subunit interface; other site 1346614009073 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1346614009074 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614009075 dimer interface [polypeptide binding]; other site 1346614009076 conserved gate region; other site 1346614009077 putative PBP binding loops; other site 1346614009078 ABC-ATPase subunit interface; other site 1346614009079 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1346614009080 interface (dimer of trimers) [polypeptide binding]; other site 1346614009081 Substrate-binding/catalytic site; other site 1346614009082 Zn-binding sites [ion binding]; other site 1346614009083 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1346614009084 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1346614009085 Walker A/P-loop; other site 1346614009086 ATP binding site [chemical binding]; other site 1346614009087 Q-loop/lid; other site 1346614009088 ABC transporter signature motif; other site 1346614009089 Walker B; other site 1346614009090 D-loop; other site 1346614009091 H-loop/switch region; other site 1346614009092 TOBE domain; Region: TOBE_2; pfam08402 1346614009093 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1346614009094 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1346614009095 DNA binding site [nucleotide binding] 1346614009096 domain linker motif; other site 1346614009097 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1346614009098 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 1346614009099 active site 1346614009100 dimer interface [polypeptide binding]; other site 1346614009101 catalytic nucleophile [active] 1346614009102 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1346614009103 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1346614009104 substrate binding pocket [chemical binding]; other site 1346614009105 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1346614009106 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1346614009107 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1346614009108 Walker A/P-loop; other site 1346614009109 ATP binding site [chemical binding]; other site 1346614009110 Q-loop/lid; other site 1346614009111 ABC transporter signature motif; other site 1346614009112 Walker B; other site 1346614009113 D-loop; other site 1346614009114 H-loop/switch region; other site 1346614009115 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1346614009116 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1346614009117 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1346614009118 Walker A/P-loop; other site 1346614009119 ATP binding site [chemical binding]; other site 1346614009120 Q-loop/lid; other site 1346614009121 ABC transporter signature motif; other site 1346614009122 Walker B; other site 1346614009123 D-loop; other site 1346614009124 H-loop/switch region; other site 1346614009125 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1346614009126 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1346614009127 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614009128 dimer interface [polypeptide binding]; other site 1346614009129 conserved gate region; other site 1346614009130 putative PBP binding loops; other site 1346614009131 ABC-ATPase subunit interface; other site 1346614009132 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1346614009133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614009134 dimer interface [polypeptide binding]; other site 1346614009135 conserved gate region; other site 1346614009136 putative PBP binding loops; other site 1346614009137 ABC-ATPase subunit interface; other site 1346614009138 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1346614009139 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1346614009140 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1346614009141 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1346614009142 DNA-binding site [nucleotide binding]; DNA binding site 1346614009143 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1346614009144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614009145 homodimer interface [polypeptide binding]; other site 1346614009146 catalytic residue [active] 1346614009147 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1346614009148 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1346614009149 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1346614009150 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1346614009151 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 1346614009152 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1346614009153 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1346614009154 putative di-iron ligands [ion binding]; other site 1346614009155 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1346614009156 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1346614009157 putative di-iron ligands [ion binding]; other site 1346614009158 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1346614009159 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1346614009160 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1346614009161 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 1346614009162 active site 1346614009163 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1346614009164 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 1346614009165 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1346614009166 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1346614009167 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1346614009168 NAD(P) binding site [chemical binding]; other site 1346614009169 active site 1346614009170 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 1346614009171 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1346614009172 dimer interface [polypeptide binding]; other site 1346614009173 active site 1346614009174 CoA binding pocket [chemical binding]; other site 1346614009175 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1346614009176 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1346614009177 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1346614009178 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1346614009179 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1346614009180 [4Fe-4S] binding site [ion binding]; other site 1346614009181 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1346614009182 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1346614009183 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1346614009184 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1346614009185 molybdopterin cofactor binding site; other site 1346614009186 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1346614009187 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1346614009188 active site 1346614009189 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1346614009190 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1346614009191 active site 1346614009192 MAPEG family; Region: MAPEG; cl09190 1346614009193 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1346614009194 The C-terminal domain of uncharacterized bacterial proteins; Region: Bvu_2165_C_like; cd12843 1346614009195 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1346614009196 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1346614009197 active site 1346614009198 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1346614009199 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 1346614009200 putative ADP-binding pocket [chemical binding]; other site 1346614009201 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1346614009202 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1346614009203 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 1346614009204 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1346614009205 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1346614009206 tyrosine kinase; Provisional; Region: PRK11519 1346614009207 Chain length determinant protein; Region: Wzz; pfam02706 1346614009208 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1346614009209 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1346614009210 Nucleotide binding site [chemical binding]; other site 1346614009211 DTAP/Switch II; other site 1346614009212 Switch I; other site 1346614009213 polysaccharide export protein Wza; Provisional; Region: PRK15078 1346614009214 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1346614009215 SLBB domain; Region: SLBB; pfam10531 1346614009216 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 1346614009217 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1346614009218 Mg++ binding site [ion binding]; other site 1346614009219 putative catalytic motif [active] 1346614009220 substrate binding site [chemical binding]; other site 1346614009221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1346614009222 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1346614009223 NAD(P) binding site [chemical binding]; other site 1346614009224 active site 1346614009225 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1346614009226 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1346614009227 DNA binding site [nucleotide binding] 1346614009228 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1346614009229 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 1346614009230 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1346614009231 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1346614009232 dimerization interface [polypeptide binding]; other site 1346614009233 Histidine kinase; Region: HisKA_3; pfam07730 1346614009234 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614009235 ATP binding site [chemical binding]; other site 1346614009236 Mg2+ binding site [ion binding]; other site 1346614009237 G-X-G motif; other site 1346614009238 transcriptional regulator NarL; Provisional; Region: PRK10651 1346614009239 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614009240 active site 1346614009241 phosphorylation site [posttranslational modification] 1346614009242 intermolecular recognition site; other site 1346614009243 dimerization interface [polypeptide binding]; other site 1346614009244 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1346614009245 DNA binding residues [nucleotide binding] 1346614009246 dimerization interface [polypeptide binding]; other site 1346614009247 putative invasin; Provisional; Region: PRK10177 1346614009248 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1346614009249 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1346614009250 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1346614009251 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1346614009252 substrate binding site [chemical binding]; other site 1346614009253 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 1346614009254 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1346614009255 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1346614009256 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1346614009257 Walker A/P-loop; other site 1346614009258 ATP binding site [chemical binding]; other site 1346614009259 Q-loop/lid; other site 1346614009260 ABC transporter signature motif; other site 1346614009261 Walker B; other site 1346614009262 D-loop; other site 1346614009263 H-loop/switch region; other site 1346614009264 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1346614009265 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1346614009266 Walker A/P-loop; other site 1346614009267 ATP binding site [chemical binding]; other site 1346614009268 Q-loop/lid; other site 1346614009269 ABC transporter signature motif; other site 1346614009270 Walker B; other site 1346614009271 D-loop; other site 1346614009272 H-loop/switch region; other site 1346614009273 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1346614009274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614009275 dimer interface [polypeptide binding]; other site 1346614009276 conserved gate region; other site 1346614009277 putative PBP binding loops; other site 1346614009278 ABC-ATPase subunit interface; other site 1346614009279 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1346614009280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614009281 dimer interface [polypeptide binding]; other site 1346614009282 conserved gate region; other site 1346614009283 putative PBP binding loops; other site 1346614009284 ABC-ATPase subunit interface; other site 1346614009285 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 1346614009286 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1346614009287 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 1346614009288 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 1346614009289 substrate binding site [chemical binding]; other site 1346614009290 dimerization interface [polypeptide binding]; other site 1346614009291 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 1346614009292 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1346614009293 putative active site pocket [active] 1346614009294 dimerization interface [polypeptide binding]; other site 1346614009295 putative catalytic residue [active] 1346614009296 cation transport regulator; Reviewed; Region: chaB; PRK09582 1346614009297 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1346614009298 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1346614009299 FAD binding pocket [chemical binding]; other site 1346614009300 FAD binding motif [chemical binding]; other site 1346614009301 phosphate binding motif [ion binding]; other site 1346614009302 NAD binding pocket [chemical binding]; other site 1346614009303 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 1346614009304 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1346614009305 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 1346614009306 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1346614009307 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1346614009308 molybdopterin cofactor binding site; other site 1346614009309 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1346614009310 molybdopterin cofactor binding site; other site 1346614009311 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1346614009312 4Fe-4S binding domain; Region: Fer4; cl02805 1346614009313 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 1346614009314 hypothetical protein; Provisional; Region: PRK10536 1346614009315 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1346614009316 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1346614009317 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1346614009318 N-terminal plug; other site 1346614009319 ligand-binding site [chemical binding]; other site 1346614009320 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1346614009321 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1346614009322 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 1346614009323 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1346614009324 Imelysin; Region: Peptidase_M75; pfam09375 1346614009325 Iron permease FTR1 family; Region: FTR1; cl00475 1346614009326 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1346614009327 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1346614009328 Na binding site [ion binding]; other site 1346614009329 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 1346614009330 Predicted transcriptional regulator [Transcription]; Region: COG3905 1346614009331 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1346614009332 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1346614009333 Glutamate binding site [chemical binding]; other site 1346614009334 NAD binding site [chemical binding]; other site 1346614009335 catalytic residues [active] 1346614009336 YcfA-like protein; Region: YcfA; pfam07927 1346614009337 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 1346614009338 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1346614009339 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 1346614009340 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1346614009341 Walker A/P-loop; other site 1346614009342 ATP binding site [chemical binding]; other site 1346614009343 Q-loop/lid; other site 1346614009344 ABC transporter signature motif; other site 1346614009345 Walker B; other site 1346614009346 D-loop; other site 1346614009347 H-loop/switch region; other site 1346614009348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614009349 dimer interface [polypeptide binding]; other site 1346614009350 conserved gate region; other site 1346614009351 putative PBP binding loops; other site 1346614009352 ABC-ATPase subunit interface; other site 1346614009353 cystine transporter subunit; Provisional; Region: PRK11260 1346614009354 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1346614009355 substrate binding pocket [chemical binding]; other site 1346614009356 membrane-bound complex binding site; other site 1346614009357 hinge residues; other site 1346614009358 D-cysteine desulfhydrase; Validated; Region: PRK03910 1346614009359 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1346614009360 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1346614009361 catalytic residue [active] 1346614009362 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 1346614009363 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1346614009364 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1346614009365 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1346614009366 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1346614009367 DNA binding residues [nucleotide binding] 1346614009368 flagellin; Validated; Region: PRK06819 1346614009369 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1346614009370 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1346614009371 flagellar capping protein; Reviewed; Region: fliD; PRK08032 1346614009372 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1346614009373 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1346614009374 flagellar protein FliS; Validated; Region: fliS; PRK05685 1346614009375 Flagellar protein FliT; Region: FliT; cl05125 1346614009376 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1346614009377 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614009378 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 1346614009379 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1346614009380 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1346614009381 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1346614009382 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1346614009383 FliG C-terminal domain; Region: FliG_C; pfam01706 1346614009384 flagellar assembly protein H; Validated; Region: fliH; PRK05687 1346614009385 Flagellar assembly protein FliH; Region: FliH; pfam02108 1346614009386 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 1346614009387 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1346614009388 Walker A motif/ATP binding site; other site 1346614009389 Walker B motif; other site 1346614009390 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1346614009391 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 1346614009392 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 1346614009393 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 1346614009394 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 1346614009395 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1346614009396 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1346614009397 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 1346614009398 Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190 1346614009399 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1346614009400 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1346614009401 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1346614009402 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 1346614009403 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1346614009404 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 1346614009405 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1346614009406 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1346614009407 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 1346614009408 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 1346614009409 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1346614009410 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1346614009411 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1346614009412 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 1346614009413 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 1346614009414 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1346614009415 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1346614009416 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1346614009417 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 1346614009418 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1346614009419 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1346614009420 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1346614009421 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1346614009422 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1346614009423 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1346614009424 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 1346614009425 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1346614009426 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1346614009427 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1346614009428 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1346614009429 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1346614009430 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1346614009431 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1346614009432 SAF-like; Region: SAF_2; pfam13144 1346614009433 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1346614009434 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1346614009435 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 1346614009436 FlgN protein; Region: FlgN; cl09176 1346614009437 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1346614009438 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1346614009439 active site 1346614009440 DNA binding site [nucleotide binding] 1346614009441 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1346614009442 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1346614009443 Catalytic site [active] 1346614009444 Flagellar protein FlhE; Region: FlhE; pfam06366 1346614009445 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1346614009446 FHIPEP family; Region: FHIPEP; pfam00771 1346614009447 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK12468 1346614009448 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1346614009449 chemotaxis regulator CheZ; Provisional; Region: PRK11166 1346614009450 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1346614009451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614009452 active site 1346614009453 phosphorylation site [posttranslational modification] 1346614009454 intermolecular recognition site; other site 1346614009455 dimerization interface [polypeptide binding]; other site 1346614009456 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1346614009457 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614009458 active site 1346614009459 phosphorylation site [posttranslational modification] 1346614009460 intermolecular recognition site; other site 1346614009461 dimerization interface [polypeptide binding]; other site 1346614009462 CheB methylesterase; Region: CheB_methylest; pfam01339 1346614009463 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614009464 methyl-accepting protein IV; Provisional; Region: PRK09793 1346614009465 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1346614009466 dimer interface [polypeptide binding]; other site 1346614009467 ligand binding site [chemical binding]; other site 1346614009468 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1346614009469 dimerization interface [polypeptide binding]; other site 1346614009470 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1346614009471 dimer interface [polypeptide binding]; other site 1346614009472 putative CheW interface [polypeptide binding]; other site 1346614009473 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1346614009474 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1346614009475 dimer interface [polypeptide binding]; other site 1346614009476 ligand binding site [chemical binding]; other site 1346614009477 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1346614009478 dimerization interface [polypeptide binding]; other site 1346614009479 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1346614009480 dimer interface [polypeptide binding]; other site 1346614009481 putative CheW interface [polypeptide binding]; other site 1346614009482 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1346614009483 putative CheA interaction surface; other site 1346614009484 chemotaxis protein CheA; Provisional; Region: PRK10547 1346614009485 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1346614009486 putative binding surface; other site 1346614009487 active site 1346614009488 CheY binding; Region: CheY-binding; pfam09078 1346614009489 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1346614009490 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614009491 ATP binding site [chemical binding]; other site 1346614009492 Mg2+ binding site [ion binding]; other site 1346614009493 G-X-G motif; other site 1346614009494 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1346614009495 flagellar motor protein MotB; Validated; Region: motB; PRK09041 1346614009496 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1346614009497 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1346614009498 ligand binding site [chemical binding]; other site 1346614009499 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1346614009500 flagellar motor protein MotA; Validated; Region: PRK09110 1346614009501 transcriptional activator FlhC; Provisional; Region: PRK12722 1346614009502 transcriptional activator FlhD; Provisional; Region: PRK02909 1346614009503 Haemolysin expression modulating protein; Region: HHA; cl11501 1346614009504 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1346614009505 Ligand Binding Site [chemical binding]; other site 1346614009506 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1346614009507 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1346614009508 NAD(P) binding site [chemical binding]; other site 1346614009509 substrate binding site [chemical binding]; other site 1346614009510 dimer interface [polypeptide binding]; other site 1346614009511 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1346614009512 putative substrate binding pocket [chemical binding]; other site 1346614009513 AC domain interface; other site 1346614009514 catalytic triad [active] 1346614009515 AB domain interface; other site 1346614009516 interchain disulfide; other site 1346614009517 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614009518 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614009519 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1346614009520 substrate binding pocket [chemical binding]; other site 1346614009521 dimerization interface [polypeptide binding]; other site 1346614009522 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 1346614009523 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1346614009524 putative active site [active] 1346614009525 putative catalytic site [active] 1346614009526 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1346614009527 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1346614009528 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1346614009529 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1346614009530 active site 1346614009531 catalytic residues [active] 1346614009532 metal binding site [ion binding]; metal-binding site 1346614009533 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1346614009534 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1346614009535 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1346614009536 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1346614009537 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1346614009538 hypothetical protein; Provisional; Region: PRK07505 1346614009539 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1346614009540 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1346614009541 catalytic residue [active] 1346614009542 Cupin-like domain; Region: Cupin_8; pfam13621 1346614009543 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614009544 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1346614009545 putative substrate translocation pore; other site 1346614009546 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1346614009547 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1346614009548 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 1346614009549 active site 1346614009550 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1346614009551 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1346614009552 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1346614009553 ArsC family; Region: ArsC; pfam03960 1346614009554 catalytic residues [active] 1346614009555 arsenical pump membrane protein; Provisional; Region: PRK15445 1346614009556 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1346614009557 transmembrane helices; other site 1346614009558 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1346614009559 putative DNA binding site [nucleotide binding]; other site 1346614009560 putative Zn2+ binding site [ion binding]; other site 1346614009561 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614009562 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614009563 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1346614009564 putative effector binding pocket; other site 1346614009565 dimerization interface [polypeptide binding]; other site 1346614009566 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1346614009567 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1346614009568 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1346614009569 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 1346614009570 magnesium-transporting ATPase; Provisional; Region: PRK15122 1346614009571 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1346614009572 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1346614009573 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1346614009574 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1346614009575 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1346614009576 magnesium transport protein MgtC; Provisional; Region: PRK15385 1346614009577 MgtC family; Region: MgtC; pfam02308 1346614009578 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 1346614009579 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1346614009580 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1346614009581 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1346614009582 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614009583 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1346614009584 dimerization interface [polypeptide binding]; other site 1346614009585 substrate binding pocket [chemical binding]; other site 1346614009586 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 1346614009587 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1346614009588 catalytic residue [active] 1346614009589 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 1346614009590 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1346614009591 DNA binding residues [nucleotide binding] 1346614009592 dimerization interface [polypeptide binding]; other site 1346614009593 hypothetical protein; Provisional; Region: PRK10708 1346614009594 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1346614009595 DNA-binding site [nucleotide binding]; DNA binding site 1346614009596 RNA-binding motif; other site 1346614009597 Ion transport protein; Region: Ion_trans; pfam00520 1346614009598 Ion channel; Region: Ion_trans_2; pfam07885 1346614009599 Double zinc ribbon; Region: DZR; pfam12773 1346614009600 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1346614009601 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1346614009602 NAD(P) binding site [chemical binding]; other site 1346614009603 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1346614009604 putative catalytic site [active] 1346614009605 putative metal binding site [ion binding]; other site 1346614009606 putative phosphate binding site [ion binding]; other site 1346614009607 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 1346614009608 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1346614009609 NAD(P) binding site [chemical binding]; other site 1346614009610 active site 1346614009611 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614009612 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614009613 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1346614009614 putative effector binding pocket; other site 1346614009615 dimerization interface [polypeptide binding]; other site 1346614009616 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 1346614009617 hypothetical protein; Provisional; Region: PRK10457 1346614009618 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614009619 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614009620 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1346614009621 putative effector binding pocket; other site 1346614009622 putative dimerization interface [polypeptide binding]; other site 1346614009623 short chain dehydrogenase; Provisional; Region: PRK12744 1346614009624 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1346614009625 NADP binding site [chemical binding]; other site 1346614009626 homodimer interface [polypeptide binding]; other site 1346614009627 active site 1346614009628 substrate binding site [chemical binding]; other site 1346614009629 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1346614009630 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1346614009631 dimer interface [polypeptide binding]; other site 1346614009632 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1346614009633 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1346614009634 metal binding site [ion binding]; metal-binding site 1346614009635 active site 1346614009636 I-site; other site 1346614009637 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004 1346614009638 Predicted ATPase [General function prediction only]; Region: COG4637 1346614009639 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1346614009640 Walker A/P-loop; other site 1346614009641 ATP binding site [chemical binding]; other site 1346614009642 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1346614009643 ABC transporter signature motif; other site 1346614009644 Walker B; other site 1346614009645 D-loop; other site 1346614009646 H-loop/switch region; other site 1346614009647 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 1346614009648 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 1346614009649 substrate binding site [chemical binding]; other site 1346614009650 dimer interface [polypeptide binding]; other site 1346614009651 NADP binding site [chemical binding]; other site 1346614009652 catalytic residues [active] 1346614009653 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 1346614009654 substrate binding site [chemical binding]; other site 1346614009655 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 1346614009656 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 1346614009657 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 1346614009658 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 1346614009659 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1346614009660 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 1346614009661 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1346614009662 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1346614009663 FAD binding pocket [chemical binding]; other site 1346614009664 FAD binding motif [chemical binding]; other site 1346614009665 phosphate binding motif [ion binding]; other site 1346614009666 beta-alpha-beta structure motif; other site 1346614009667 NAD(p) ribose binding residues [chemical binding]; other site 1346614009668 NAD binding pocket [chemical binding]; other site 1346614009669 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1346614009670 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1346614009671 catalytic loop [active] 1346614009672 iron binding site [ion binding]; other site 1346614009673 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 1346614009674 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1346614009675 substrate binding site [chemical binding]; other site 1346614009676 oxyanion hole (OAH) forming residues; other site 1346614009677 trimer interface [polypeptide binding]; other site 1346614009678 enoyl-CoA hydratase; Provisional; Region: PRK08140 1346614009679 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1346614009680 substrate binding site [chemical binding]; other site 1346614009681 oxyanion hole (OAH) forming residues; other site 1346614009682 trimer interface [polypeptide binding]; other site 1346614009683 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 1346614009684 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1346614009685 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1346614009686 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1346614009687 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1346614009688 CoenzymeA binding site [chemical binding]; other site 1346614009689 subunit interaction site [polypeptide binding]; other site 1346614009690 PHB binding site; other site 1346614009691 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1346614009692 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1346614009693 dimer interface [polypeptide binding]; other site 1346614009694 active site 1346614009695 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 1346614009696 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1346614009697 active site 1346614009698 AMP binding site [chemical binding]; other site 1346614009699 homodimer interface [polypeptide binding]; other site 1346614009700 acyl-activating enzyme (AAE) consensus motif; other site 1346614009701 CoA binding site [chemical binding]; other site 1346614009702 PaaX-like protein; Region: PaaX; pfam07848 1346614009703 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 1346614009704 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1346614009705 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 1346614009706 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 1346614009707 putative trimer interface [polypeptide binding]; other site 1346614009708 putative metal binding site [ion binding]; other site 1346614009709 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1346614009710 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1346614009711 DNA-binding site [nucleotide binding]; DNA binding site 1346614009712 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1346614009713 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614009714 homodimer interface [polypeptide binding]; other site 1346614009715 catalytic residue [active] 1346614009716 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1346614009717 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1346614009718 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1346614009719 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1346614009720 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614009721 homodimer interface [polypeptide binding]; other site 1346614009722 catalytic residue [active] 1346614009723 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1346614009724 homotrimer interaction site [polypeptide binding]; other site 1346614009725 putative active site [active] 1346614009726 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1346614009727 LysR family transcriptional regulator; Provisional; Region: PRK14997 1346614009728 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614009729 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 1346614009730 putative effector binding pocket; other site 1346614009731 putative dimerization interface [polypeptide binding]; other site 1346614009732 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1346614009733 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1346614009734 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 1346614009735 putative N-terminal domain interface [polypeptide binding]; other site 1346614009736 putative dimer interface [polypeptide binding]; other site 1346614009737 putative substrate binding pocket (H-site) [chemical binding]; other site 1346614009738 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1346614009739 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1346614009740 Glycogen synthesis protein; Region: GlgS; cl11663 1346614009741 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 1346614009742 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1346614009743 tetramerization interface [polypeptide binding]; other site 1346614009744 NAD(P) binding site [chemical binding]; other site 1346614009745 catalytic residues [active] 1346614009746 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 1346614009747 dimer interface [polypeptide binding]; other site 1346614009748 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1346614009749 ligand binding site [chemical binding]; other site 1346614009750 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1346614009751 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1346614009752 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1346614009753 active site 1346614009754 catalytic tetrad [active] 1346614009755 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1346614009756 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1346614009757 Trp docking motif [polypeptide binding]; other site 1346614009758 putative active site [active] 1346614009759 galactoside permease; Reviewed; Region: lacY; PRK09528 1346614009760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614009761 putative substrate translocation pore; other site 1346614009762 alpha-galactosidase; Provisional; Region: PRK15076 1346614009763 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1346614009764 NAD binding site [chemical binding]; other site 1346614009765 sugar binding site [chemical binding]; other site 1346614009766 divalent metal binding site [ion binding]; other site 1346614009767 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1346614009768 dimer interface [polypeptide binding]; other site 1346614009769 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1346614009770 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1346614009771 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614009772 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614009773 MATE family multidrug exporter; Provisional; Region: PRK10189 1346614009774 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 1346614009775 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1346614009776 acyl-CoA synthetase; Validated; Region: PRK09192 1346614009777 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1346614009778 acyl-activating enzyme (AAE) consensus motif; other site 1346614009779 active site 1346614009780 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1346614009781 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1346614009782 NAD(P) binding site [chemical binding]; other site 1346614009783 active site 1346614009784 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1346614009785 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1346614009786 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1346614009787 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1346614009788 catalytic residue [active] 1346614009789 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1346614009790 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1346614009791 TMP-binding site; other site 1346614009792 ATP-binding site [chemical binding]; other site 1346614009793 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1346614009794 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1346614009795 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1346614009796 active site 1346614009797 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1346614009798 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 1346614009799 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1346614009800 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 1346614009801 Predicted permeases [General function prediction only]; Region: COG0795 1346614009802 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1346614009803 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1346614009804 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1346614009805 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1346614009806 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 1346614009807 active site 1346614009808 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1346614009809 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 1346614009810 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1346614009811 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 1346614009812 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1346614009813 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1346614009814 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614009815 Isochorismatase family; Region: Isochorismatase; pfam00857 1346614009816 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1346614009817 catalytic triad [active] 1346614009818 conserved cis-peptide bond; other site 1346614009819 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1346614009820 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1346614009821 conserved cys residue [active] 1346614009822 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614009823 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 1346614009824 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1346614009825 TMP-binding site; other site 1346614009826 ATP-binding site [chemical binding]; other site 1346614009827 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614009828 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614009829 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1346614009830 putative effector binding pocket; other site 1346614009831 dimerization interface [polypeptide binding]; other site 1346614009832 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614009833 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1346614009834 putative substrate translocation pore; other site 1346614009835 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1346614009836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614009837 putative substrate translocation pore; other site 1346614009838 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1346614009839 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614009840 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614009841 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1346614009842 putative effector binding pocket; other site 1346614009843 putative dimerization interface [polypeptide binding]; other site 1346614009844 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1346614009845 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1346614009846 DNA binding site [nucleotide binding] 1346614009847 domain linker motif; other site 1346614009848 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 1346614009849 putative dimerization interface [polypeptide binding]; other site 1346614009850 putative ligand binding site [chemical binding]; other site 1346614009851 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 1346614009852 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1346614009853 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1346614009854 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614009855 dimer interface [polypeptide binding]; other site 1346614009856 conserved gate region; other site 1346614009857 putative PBP binding loops; other site 1346614009858 ABC-ATPase subunit interface; other site 1346614009859 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614009860 dimer interface [polypeptide binding]; other site 1346614009861 conserved gate region; other site 1346614009862 putative PBP binding loops; other site 1346614009863 ABC-ATPase subunit interface; other site 1346614009864 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1346614009865 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1346614009866 Walker A/P-loop; other site 1346614009867 ATP binding site [chemical binding]; other site 1346614009868 Q-loop/lid; other site 1346614009869 ABC transporter signature motif; other site 1346614009870 Walker B; other site 1346614009871 D-loop; other site 1346614009872 H-loop/switch region; other site 1346614009873 TOBE domain; Region: TOBE_2; pfam08402 1346614009874 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1346614009875 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 1346614009876 active site 1346614009877 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1346614009878 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1346614009879 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1346614009880 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1346614009881 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1346614009882 conserved cys residue [active] 1346614009883 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614009884 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614009885 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1346614009886 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1346614009887 Putative transcription activator [Transcription]; Region: TenA; COG0819 1346614009888 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1346614009889 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1346614009890 Walker A/P-loop; other site 1346614009891 ATP binding site [chemical binding]; other site 1346614009892 Q-loop/lid; other site 1346614009893 ABC transporter signature motif; other site 1346614009894 Walker B; other site 1346614009895 D-loop; other site 1346614009896 H-loop/switch region; other site 1346614009897 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1346614009898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614009899 dimer interface [polypeptide binding]; other site 1346614009900 conserved gate region; other site 1346614009901 putative PBP binding loops; other site 1346614009902 ABC-ATPase subunit interface; other site 1346614009903 NMT1/THI5 like; Region: NMT1; pfam09084 1346614009904 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 1346614009905 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1346614009906 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1346614009907 substrate binding pocket [chemical binding]; other site 1346614009908 membrane-bound complex binding site; other site 1346614009909 hinge residues; other site 1346614009910 phosphoglycerol transferase I; Provisional; Region: PRK03776 1346614009911 AMP nucleosidase; Provisional; Region: PRK08292 1346614009912 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1346614009913 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1346614009914 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 1346614009915 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1346614009916 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1346614009917 Protein export membrane protein; Region: SecD_SecF; cl14618 1346614009918 Protein export membrane protein; Region: SecD_SecF; cl14618 1346614009919 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1346614009920 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1346614009921 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1346614009922 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614009923 active site 1346614009924 phosphorylation site [posttranslational modification] 1346614009925 intermolecular recognition site; other site 1346614009926 dimerization interface [polypeptide binding]; other site 1346614009927 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1346614009928 DNA binding site [nucleotide binding] 1346614009929 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1346614009930 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1346614009931 dimer interface [polypeptide binding]; other site 1346614009932 phosphorylation site [posttranslational modification] 1346614009933 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614009934 ATP binding site [chemical binding]; other site 1346614009935 Mg2+ binding site [ion binding]; other site 1346614009936 G-X-G motif; other site 1346614009937 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 1346614009938 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614009939 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1346614009940 putative dimerization interface [polypeptide binding]; other site 1346614009941 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 1346614009942 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1346614009943 substrate binding site [chemical binding]; other site 1346614009944 THF binding site; other site 1346614009945 zinc-binding site [ion binding]; other site 1346614009946 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614009947 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614009948 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 1346614009949 putative effector binding pocket; other site 1346614009950 putative dimerization interface [polypeptide binding]; other site 1346614009951 NmrA-like family; Region: NmrA; pfam05368 1346614009952 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1346614009953 NADP binding site [chemical binding]; other site 1346614009954 outer membrane receptor FepA; Provisional; Region: PRK13528 1346614009955 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1346614009956 N-terminal plug; other site 1346614009957 ligand-binding site [chemical binding]; other site 1346614009958 Protein of unknown function, DUF606; Region: DUF606; cl01273 1346614009959 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1346614009960 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614009961 Coenzyme A binding pocket [chemical binding]; other site 1346614009962 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1346614009963 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1346614009964 sequence-specific DNA binding site [nucleotide binding]; other site 1346614009965 salt bridge; other site 1346614009966 Cupin domain; Region: Cupin_2; pfam07883 1346614009967 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 1346614009968 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 1346614009969 putative FMN binding site [chemical binding]; other site 1346614009970 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1346614009971 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614009972 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1346614009973 dimerization interface [polypeptide binding]; other site 1346614009974 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1346614009975 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1346614009976 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1346614009977 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1346614009978 putative active site [active] 1346614009979 O-Antigen ligase; Region: Wzy_C; pfam04932 1346614009980 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 1346614009981 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 1346614009982 alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030 1346614009983 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 1346614009984 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1346614009985 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1346614009986 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1346614009987 Walker A/P-loop; other site 1346614009988 ATP binding site [chemical binding]; other site 1346614009989 Q-loop/lid; other site 1346614009990 ABC transporter signature motif; other site 1346614009991 Walker B; other site 1346614009992 D-loop; other site 1346614009993 H-loop/switch region; other site 1346614009994 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 1346614009995 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1346614009996 Walker A/P-loop; other site 1346614009997 ATP binding site [chemical binding]; other site 1346614009998 Q-loop/lid; other site 1346614009999 ABC transporter signature motif; other site 1346614010000 Walker B; other site 1346614010001 D-loop; other site 1346614010002 H-loop/switch region; other site 1346614010003 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1346614010004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614010005 putative PBP binding loops; other site 1346614010006 ABC-ATPase subunit interface; other site 1346614010007 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1346614010008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614010009 dimer interface [polypeptide binding]; other site 1346614010010 conserved gate region; other site 1346614010011 ABC-ATPase subunit interface; other site 1346614010012 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1346614010013 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 1346614010014 alanine-tRNA ligase; Region: PLN02961 1346614010015 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1346614010016 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614010017 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614010018 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1346614010019 putative effector binding pocket; other site 1346614010020 dimerization interface [polypeptide binding]; other site 1346614010021 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 1346614010022 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1346614010023 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1346614010024 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1346614010025 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 1346614010026 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1346614010027 catalytic core [active] 1346614010028 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1346614010029 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1346614010030 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1346614010031 transmembrane helices; other site 1346614010032 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 1346614010033 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 1346614010034 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 1346614010035 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1346614010036 citrate lyase subunit gamma; Provisional; Region: PRK13253 1346614010037 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 1346614010038 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 1346614010039 putative active site [active] 1346614010040 (T/H)XGH motif; other site 1346614010041 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 1346614010042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614010043 active site 1346614010044 phosphorylation site [posttranslational modification] 1346614010045 intermolecular recognition site; other site 1346614010046 dimerization interface [polypeptide binding]; other site 1346614010047 Transcriptional regulator; Region: CitT; pfam12431 1346614010048 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 1346614010049 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1346614010050 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1346614010051 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1346614010052 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 1346614010053 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1346614010054 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1346614010055 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1346614010056 dimer interface [polypeptide binding]; other site 1346614010057 active site 1346614010058 heme binding site [chemical binding]; other site 1346614010059 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1346614010060 benzoate transport; Region: 2A0115; TIGR00895 1346614010061 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614010062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614010063 putative substrate translocation pore; other site 1346614010064 putative arabinose transporter; Provisional; Region: PRK03545 1346614010065 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614010066 putative substrate translocation pore; other site 1346614010067 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1346614010068 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1346614010069 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1346614010070 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1346614010071 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1346614010072 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1346614010073 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1346614010074 DNA binding site [nucleotide binding] 1346614010075 domain linker motif; other site 1346614010076 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 1346614010077 putative dimerization interface [polypeptide binding]; other site 1346614010078 putative ligand binding site [chemical binding]; other site 1346614010079 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 1346614010080 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1346614010081 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1346614010082 Walker A/P-loop; other site 1346614010083 ATP binding site [chemical binding]; other site 1346614010084 Q-loop/lid; other site 1346614010085 ABC transporter signature motif; other site 1346614010086 Walker B; other site 1346614010087 D-loop; other site 1346614010088 H-loop/switch region; other site 1346614010089 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1346614010090 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1346614010091 Walker A/P-loop; other site 1346614010092 ATP binding site [chemical binding]; other site 1346614010093 Q-loop/lid; other site 1346614010094 ABC transporter signature motif; other site 1346614010095 Walker B; other site 1346614010096 D-loop; other site 1346614010097 H-loop/switch region; other site 1346614010098 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1346614010099 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1346614010100 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1346614010101 TM-ABC transporter signature motif; other site 1346614010102 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1346614010103 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1346614010104 TM-ABC transporter signature motif; other site 1346614010105 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1346614010106 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1346614010107 dimerization interface [polypeptide binding]; other site 1346614010108 ligand binding site [chemical binding]; other site 1346614010109 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1346614010110 Protein of unknown function (DUF3916); Region: DUF3916; pfam13079 1346614010111 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1346614010112 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 1346614010113 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614010114 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1346614010115 dimerization interface [polypeptide binding]; other site 1346614010116 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1346614010117 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1346614010118 metal binding site [ion binding]; metal-binding site 1346614010119 putative dimer interface [polypeptide binding]; other site 1346614010120 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1346614010121 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1346614010122 substrate binding pocket [chemical binding]; other site 1346614010123 membrane-bound complex binding site; other site 1346614010124 hinge residues; other site 1346614010125 hypothetical protein; Provisional; Region: PRK05423 1346614010126 Predicted membrane protein [Function unknown]; Region: COG1289 1346614010127 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1346614010128 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1346614010129 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1346614010130 amidase catalytic site [active] 1346614010131 Zn binding residues [ion binding]; other site 1346614010132 substrate binding site [chemical binding]; other site 1346614010133 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1346614010134 non-specific DNA binding site [nucleotide binding]; other site 1346614010135 salt bridge; other site 1346614010136 sequence-specific DNA binding site [nucleotide binding]; other site 1346614010137 Predicted transcriptional regulator [Transcription]; Region: COG2932 1346614010138 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1346614010139 Catalytic site [active] 1346614010140 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1346614010141 NAD(P) binding site [chemical binding]; other site 1346614010142 active site 1346614010143 DNA polymerase III, theta subunit; Region: DNA_pol3_theta; cl11635 1346614010144 exonuclease I; Provisional; Region: sbcB; PRK11779 1346614010145 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1346614010146 active site 1346614010147 catalytic site [active] 1346614010148 substrate binding site [chemical binding]; other site 1346614010149 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1346614010150 amino acid transporter; Region: 2A0306; TIGR00909 1346614010151 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1346614010152 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1346614010153 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1346614010154 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1346614010155 non-specific DNA binding site [nucleotide binding]; other site 1346614010156 salt bridge; other site 1346614010157 sequence-specific DNA binding site [nucleotide binding]; other site 1346614010158 Cupin domain; Region: Cupin_2; pfam07883 1346614010159 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1346614010160 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1346614010161 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1346614010162 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1346614010163 Walker A/P-loop; other site 1346614010164 ATP binding site [chemical binding]; other site 1346614010165 Q-loop/lid; other site 1346614010166 ABC transporter signature motif; other site 1346614010167 Walker B; other site 1346614010168 D-loop; other site 1346614010169 H-loop/switch region; other site 1346614010170 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1346614010171 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1346614010172 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1346614010173 TM-ABC transporter signature motif; other site 1346614010174 putative outer membrane receptor; Provisional; Region: PRK13513 1346614010175 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1346614010176 N-terminal plug; other site 1346614010177 ligand-binding site [chemical binding]; other site 1346614010178 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1346614010179 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1346614010180 putative ligand binding residues [chemical binding]; other site 1346614010181 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1346614010182 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1346614010183 Walker A/P-loop; other site 1346614010184 ATP binding site [chemical binding]; other site 1346614010185 Q-loop/lid; other site 1346614010186 ABC transporter signature motif; other site 1346614010187 Walker B; other site 1346614010188 D-loop; other site 1346614010189 H-loop/switch region; other site 1346614010190 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1346614010191 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1346614010192 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1346614010193 ABC-ATPase subunit interface; other site 1346614010194 dimer interface [polypeptide binding]; other site 1346614010195 putative PBP binding regions; other site 1346614010196 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1346614010197 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1346614010198 metal binding site [ion binding]; metal-binding site 1346614010199 active site 1346614010200 I-site; other site 1346614010201 lysine transporter; Provisional; Region: PRK10836 1346614010202 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1346614010203 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614010204 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1346614010205 putative dimerization interface [polypeptide binding]; other site 1346614010206 Predicted membrane protein [Function unknown]; Region: COG2855 1346614010207 endonuclease IV; Provisional; Region: PRK01060 1346614010208 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1346614010209 AP (apurinic/apyrimidinic) site pocket; other site 1346614010210 DNA interaction; other site 1346614010211 Metal-binding active site; metal-binding site 1346614010212 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 1346614010213 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 1346614010214 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1346614010215 active site 1346614010216 P-loop; other site 1346614010217 phosphorylation site [posttranslational modification] 1346614010218 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 1346614010219 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1346614010220 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1346614010221 putative substrate binding site [chemical binding]; other site 1346614010222 putative ATP binding site [chemical binding]; other site 1346614010223 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 1346614010224 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1346614010225 active site 1346614010226 phosphorylation site [posttranslational modification] 1346614010227 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1346614010228 dimerization domain swap beta strand [polypeptide binding]; other site 1346614010229 regulatory protein interface [polypeptide binding]; other site 1346614010230 active site 1346614010231 regulatory phosphorylation site [posttranslational modification]; other site 1346614010232 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_19; cd04678 1346614010233 nudix motif; other site 1346614010234 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 1346614010235 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1346614010236 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1346614010237 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1346614010238 molybdopterin cofactor binding site [chemical binding]; other site 1346614010239 substrate binding site [chemical binding]; other site 1346614010240 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1346614010241 molybdopterin cofactor binding site; other site 1346614010242 sugar efflux transporter B; Provisional; Region: PRK15011 1346614010243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614010244 putative substrate translocation pore; other site 1346614010245 Flagellin N-methylase; Region: FliB; cl00497 1346614010246 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1346614010247 aromatic amino acid transport protein; Region: araaP; TIGR00837 1346614010248 elongation factor P; Provisional; Region: PRK04542 1346614010249 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1346614010250 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1346614010251 RNA binding site [nucleotide binding]; other site 1346614010252 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1346614010253 RNA binding site [nucleotide binding]; other site 1346614010254 mannonate dehydratase; Provisional; Region: PRK03906 1346614010255 mannonate dehydratase; Region: uxuA; TIGR00695 1346614010256 D-mannonate oxidoreductase; Provisional; Region: PRK15037 1346614010257 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1346614010258 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1346614010259 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1346614010260 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1346614010261 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1346614010262 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1346614010263 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1346614010264 active site 1346614010265 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 1346614010266 NlpC/P60 family; Region: NLPC_P60; pfam00877 1346614010267 phage resistance protein; Provisional; Region: PRK10551 1346614010268 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1346614010269 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1346614010270 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1346614010271 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1346614010272 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1346614010273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614010274 dimer interface [polypeptide binding]; other site 1346614010275 conserved gate region; other site 1346614010276 putative PBP binding loops; other site 1346614010277 ABC-ATPase subunit interface; other site 1346614010278 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 1346614010279 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1346614010280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614010281 dimer interface [polypeptide binding]; other site 1346614010282 conserved gate region; other site 1346614010283 putative PBP binding loops; other site 1346614010284 ABC-ATPase subunit interface; other site 1346614010285 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 1346614010286 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1346614010287 Walker A/P-loop; other site 1346614010288 ATP binding site [chemical binding]; other site 1346614010289 Q-loop/lid; other site 1346614010290 ABC transporter signature motif; other site 1346614010291 Walker B; other site 1346614010292 D-loop; other site 1346614010293 H-loop/switch region; other site 1346614010294 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1346614010295 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1346614010296 Walker A/P-loop; other site 1346614010297 ATP binding site [chemical binding]; other site 1346614010298 Q-loop/lid; other site 1346614010299 ABC transporter signature motif; other site 1346614010300 Walker B; other site 1346614010301 D-loop; other site 1346614010302 H-loop/switch region; other site 1346614010303 hypothetical protein; Provisional; Region: PRK11835 1346614010304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614010305 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1346614010306 putative substrate translocation pore; other site 1346614010307 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 1346614010308 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1346614010309 RNA binding surface [nucleotide binding]; other site 1346614010310 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1346614010311 active site 1346614010312 uracil binding [chemical binding]; other site 1346614010313 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1346614010314 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1346614010315 ATP binding site [chemical binding]; other site 1346614010316 putative Mg++ binding site [ion binding]; other site 1346614010317 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1346614010318 nucleotide binding region [chemical binding]; other site 1346614010319 ATP-binding site [chemical binding]; other site 1346614010320 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1346614010321 5S rRNA interface [nucleotide binding]; other site 1346614010322 CTC domain interface [polypeptide binding]; other site 1346614010323 L16 interface [polypeptide binding]; other site 1346614010324 Nucleoid-associated protein [General function prediction only]; Region: COG3081 1346614010325 nucleoid-associated protein NdpA; Validated; Region: PRK00378 1346614010326 hypothetical protein; Provisional; Region: PRK13689 1346614010327 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 1346614010328 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 1346614010329 Sulfatase; Region: Sulfatase; cl17466 1346614010330 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 1346614010331 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1346614010332 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1346614010333 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1346614010334 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 1346614010335 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1346614010336 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614010337 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614010338 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1346614010339 dimerization interface [polypeptide binding]; other site 1346614010340 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 1346614010341 SnoaL-like domain; Region: SnoaL_2; pfam12680 1346614010342 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1346614010343 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1346614010344 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1346614010345 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 1346614010346 putative metal binding site [ion binding]; other site 1346614010347 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1346614010348 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1346614010349 trimer interface [polypeptide binding]; other site 1346614010350 eyelet of channel; other site 1346614010351 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 1346614010352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614010353 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1346614010354 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 1346614010355 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614010356 ATP binding site [chemical binding]; other site 1346614010357 Mg2+ binding site [ion binding]; other site 1346614010358 G-X-G motif; other site 1346614010359 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1346614010360 putative binding surface; other site 1346614010361 active site 1346614010362 transcriptional regulator RcsB; Provisional; Region: PRK10840 1346614010363 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614010364 active site 1346614010365 phosphorylation site [posttranslational modification] 1346614010366 intermolecular recognition site; other site 1346614010367 dimerization interface [polypeptide binding]; other site 1346614010368 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1346614010369 DNA binding residues [nucleotide binding] 1346614010370 dimerization interface [polypeptide binding]; other site 1346614010371 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 1346614010372 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1346614010373 dimer interface [polypeptide binding]; other site 1346614010374 phosphorylation site [posttranslational modification] 1346614010375 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614010376 ATP binding site [chemical binding]; other site 1346614010377 Mg2+ binding site [ion binding]; other site 1346614010378 G-X-G motif; other site 1346614010379 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 1346614010380 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614010381 active site 1346614010382 phosphorylation site [posttranslational modification] 1346614010383 intermolecular recognition site; other site 1346614010384 dimerization interface [polypeptide binding]; other site 1346614010385 DNA gyrase subunit A; Validated; Region: PRK05560 1346614010386 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1346614010387 CAP-like domain; other site 1346614010388 active site 1346614010389 primary dimer interface [polypeptide binding]; other site 1346614010390 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1346614010391 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1346614010392 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1346614010393 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1346614010394 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1346614010395 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1346614010396 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1346614010397 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614010398 S-adenosylmethionine binding site [chemical binding]; other site 1346614010399 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1346614010400 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1346614010401 DNA-binding site [nucleotide binding]; DNA binding site 1346614010402 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1346614010403 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 1346614010404 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614010405 D-galactonate transporter; Region: 2A0114; TIGR00893 1346614010406 putative substrate translocation pore; other site 1346614010407 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1346614010408 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1346614010409 putative NAD(P) binding site [chemical binding]; other site 1346614010410 catalytic Zn binding site [ion binding]; other site 1346614010411 structural Zn binding site [ion binding]; other site 1346614010412 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1346614010413 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1346614010414 NAD(P) binding site [chemical binding]; other site 1346614010415 active site 1346614010416 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1346614010417 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1346614010418 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 1346614010419 ATP cone domain; Region: ATP-cone; pfam03477 1346614010420 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1346614010421 active site 1346614010422 dimer interface [polypeptide binding]; other site 1346614010423 catalytic residues [active] 1346614010424 effector binding site; other site 1346614010425 R2 peptide binding site; other site 1346614010426 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1346614010427 dimer interface [polypeptide binding]; other site 1346614010428 putative radical transfer pathway; other site 1346614010429 diiron center [ion binding]; other site 1346614010430 tyrosyl radical; other site 1346614010431 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1346614010432 catalytic loop [active] 1346614010433 iron binding site [ion binding]; other site 1346614010434 hypothetical protein; Provisional; Region: PRK03673 1346614010435 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1346614010436 putative MPT binding site; other site 1346614010437 Competence-damaged protein; Region: CinA; pfam02464 1346614010438 tyrosine transporter TyrP; Provisional; Region: PRK15132 1346614010439 aromatic amino acid transport protein; Region: araaP; TIGR00837 1346614010440 YfaZ precursor; Region: YfaZ; pfam07437 1346614010441 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1346614010442 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1346614010443 tetramer interface [polypeptide binding]; other site 1346614010444 heme binding pocket [chemical binding]; other site 1346614010445 NADPH binding site [chemical binding]; other site 1346614010446 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 1346614010447 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1346614010448 acyl-activating enzyme (AAE) consensus motif; other site 1346614010449 putative AMP binding site [chemical binding]; other site 1346614010450 putative active site [active] 1346614010451 putative CoA binding site [chemical binding]; other site 1346614010452 O-succinylbenzoate synthase; Provisional; Region: PRK05105 1346614010453 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1346614010454 active site 1346614010455 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1346614010456 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1346614010457 substrate binding site [chemical binding]; other site 1346614010458 oxyanion hole (OAH) forming residues; other site 1346614010459 trimer interface [polypeptide binding]; other site 1346614010460 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 1346614010461 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1346614010462 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1346614010463 dimer interface [polypeptide binding]; other site 1346614010464 tetramer interface [polypeptide binding]; other site 1346614010465 PYR/PP interface [polypeptide binding]; other site 1346614010466 TPP binding site [chemical binding]; other site 1346614010467 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1346614010468 TPP-binding site; other site 1346614010469 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 1346614010470 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1346614010471 Putative glucoamylase; Region: Glycoamylase; pfam10091 1346614010472 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 1346614010473 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 1346614010474 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 1346614010475 hypothetical protein; Provisional; Region: PRK10404 1346614010476 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 1346614010477 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 1346614010478 putative NAD(P) binding site [chemical binding]; other site 1346614010479 catalytic Zn binding site [ion binding]; other site 1346614010480 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 1346614010481 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1346614010482 NADP binding site [chemical binding]; other site 1346614010483 homodimer interface [polypeptide binding]; other site 1346614010484 active site 1346614010485 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 1346614010486 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1346614010487 DNA binding site [nucleotide binding] 1346614010488 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1346614010489 putative ligand binding site [chemical binding]; other site 1346614010490 putative dimerization interface [polypeptide binding]; other site 1346614010491 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 1346614010492 Transmembrane secretion effector; Region: MFS_3; pfam05977 1346614010493 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1346614010494 EamA-like transporter family; Region: EamA; cl17759 1346614010495 Cupin domain; Region: Cupin_2; cl17218 1346614010496 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1346614010497 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1346614010498 PYR/PP interface [polypeptide binding]; other site 1346614010499 dimer interface [polypeptide binding]; other site 1346614010500 TPP binding site [chemical binding]; other site 1346614010501 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1346614010502 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1346614010503 TPP-binding site [chemical binding]; other site 1346614010504 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614010505 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614010506 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1346614010507 dimerization interface [polypeptide binding]; other site 1346614010508 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1346614010509 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1346614010510 non-specific DNA binding site [nucleotide binding]; other site 1346614010511 salt bridge; other site 1346614010512 sequence-specific DNA binding site [nucleotide binding]; other site 1346614010513 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1346614010514 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1346614010515 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1346614010516 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1346614010517 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1346614010518 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1346614010519 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1346614010520 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1346614010521 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1346614010522 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1346614010523 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1346614010524 4Fe-4S binding domain; Region: Fer4; pfam00037 1346614010525 4Fe-4S binding domain; Region: Fer4; pfam00037 1346614010526 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1346614010527 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 1346614010528 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1346614010529 catalytic loop [active] 1346614010530 iron binding site [ion binding]; other site 1346614010531 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1346614010532 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1346614010533 [4Fe-4S] binding site [ion binding]; other site 1346614010534 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1346614010535 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 1346614010536 SLBB domain; Region: SLBB; pfam10531 1346614010537 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1346614010538 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1346614010539 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1346614010540 putative dimer interface [polypeptide binding]; other site 1346614010541 [2Fe-2S] cluster binding site [ion binding]; other site 1346614010542 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 1346614010543 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1346614010544 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1346614010545 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 1346614010546 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1346614010547 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 1346614010548 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614010549 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 1346614010550 putative dimerization interface [polypeptide binding]; other site 1346614010551 aminotransferase AlaT; Validated; Region: PRK09265 1346614010552 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1346614010553 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614010554 homodimer interface [polypeptide binding]; other site 1346614010555 catalytic residue [active] 1346614010556 5'-nucleotidase; Provisional; Region: PRK03826 1346614010557 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1346614010558 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1346614010559 TrkA-C domain; Region: TrkA_C; pfam02080 1346614010560 TrkA-C domain; Region: TrkA_C; pfam02080 1346614010561 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1346614010562 putative phosphatase; Provisional; Region: PRK11587 1346614010563 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1346614010564 motif II; other site 1346614010565 hypothetical protein; Validated; Region: PRK05445 1346614010566 hypothetical protein; Provisional; Region: PRK01816 1346614010567 propionate/acetate kinase; Provisional; Region: PRK12379 1346614010568 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1346614010569 phosphate acetyltransferase; Reviewed; Region: PRK05632 1346614010570 DRTGG domain; Region: DRTGG; pfam07085 1346614010571 phosphate acetyltransferase; Region: pta; TIGR00651 1346614010572 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 1346614010573 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 1346614010574 nudix motif; other site 1346614010575 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1346614010576 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1346614010577 active site 1346614010578 metal binding site [ion binding]; metal-binding site 1346614010579 homotetramer interface [polypeptide binding]; other site 1346614010580 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1346614010581 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1346614010582 C-terminal domain interface [polypeptide binding]; other site 1346614010583 GSH binding site (G-site) [chemical binding]; other site 1346614010584 dimer interface [polypeptide binding]; other site 1346614010585 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1346614010586 N-terminal domain interface [polypeptide binding]; other site 1346614010587 putative dimer interface [polypeptide binding]; other site 1346614010588 active site 1346614010589 D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase; Provisional; Region: folX; PRK11245 1346614010590 active site 1346614010591 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1346614010592 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1346614010593 putative NAD(P) binding site [chemical binding]; other site 1346614010594 putative active site [active] 1346614010595 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 1346614010596 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1346614010597 Walker A/P-loop; other site 1346614010598 ATP binding site [chemical binding]; other site 1346614010599 Q-loop/lid; other site 1346614010600 ABC transporter signature motif; other site 1346614010601 Walker B; other site 1346614010602 D-loop; other site 1346614010603 H-loop/switch region; other site 1346614010604 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1346614010605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614010606 dimer interface [polypeptide binding]; other site 1346614010607 conserved gate region; other site 1346614010608 putative PBP binding loops; other site 1346614010609 ABC-ATPase subunit interface; other site 1346614010610 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1346614010611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614010612 dimer interface [polypeptide binding]; other site 1346614010613 conserved gate region; other site 1346614010614 putative PBP binding loops; other site 1346614010615 ABC-ATPase subunit interface; other site 1346614010616 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1346614010617 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1346614010618 substrate binding pocket [chemical binding]; other site 1346614010619 membrane-bound complex binding site; other site 1346614010620 hinge residues; other site 1346614010621 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 1346614010622 Flavoprotein; Region: Flavoprotein; pfam02441 1346614010623 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1346614010624 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1346614010625 active site 1346614010626 tetramer interface [polypeptide binding]; other site 1346614010627 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1346614010628 active site 1346614010629 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1346614010630 colicin V production protein; Provisional; Region: PRK10845 1346614010631 cell division protein DedD; Provisional; Region: PRK11633 1346614010632 cell division protein DedD; Provisional; Region: PRK11633 1346614010633 Sporulation related domain; Region: SPOR; pfam05036 1346614010634 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 1346614010635 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1346614010636 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1346614010637 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1346614010638 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1346614010639 hypothetical protein; Provisional; Region: PRK10847 1346614010640 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1346614010641 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1346614010642 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1346614010643 dimerization interface 3.5A [polypeptide binding]; other site 1346614010644 active site 1346614010645 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 1346614010646 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1346614010647 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 1346614010648 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 1346614010649 ligand binding site [chemical binding]; other site 1346614010650 NAD binding site [chemical binding]; other site 1346614010651 catalytic site [active] 1346614010652 homodimer interface [polypeptide binding]; other site 1346614010653 Cupin domain; Region: Cupin_2; cl17218 1346614010654 Helix-turn-helix domain; Region: HTH_18; pfam12833 1346614010655 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614010656 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1346614010657 EamA-like transporter family; Region: EamA; pfam00892 1346614010658 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1346614010659 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1346614010660 HAMP domain; Region: HAMP; pfam00672 1346614010661 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1346614010662 dimer interface [polypeptide binding]; other site 1346614010663 phosphorylation site [posttranslational modification] 1346614010664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614010665 ATP binding site [chemical binding]; other site 1346614010666 Mg2+ binding site [ion binding]; other site 1346614010667 G-X-G motif; other site 1346614010668 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 1346614010669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614010670 active site 1346614010671 phosphorylation site [posttranslational modification] 1346614010672 intermolecular recognition site; other site 1346614010673 dimerization interface [polypeptide binding]; other site 1346614010674 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1346614010675 DNA binding site [nucleotide binding] 1346614010676 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1346614010677 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1346614010678 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1346614010679 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1346614010680 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1346614010681 trimer interface [polypeptide binding]; other site 1346614010682 active site 1346614010683 substrate binding site [chemical binding]; other site 1346614010684 CoA binding site [chemical binding]; other site 1346614010685 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1346614010686 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1346614010687 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1346614010688 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1346614010689 DNA-binding site [nucleotide binding]; DNA binding site 1346614010690 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1346614010691 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614010692 homodimer interface [polypeptide binding]; other site 1346614010693 catalytic residue [active] 1346614010694 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1346614010695 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1346614010696 catalytic residues [active] 1346614010697 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 1346614010698 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1346614010699 catalytic residues [active] 1346614010700 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 1346614010701 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 1346614010702 active site residue [active] 1346614010703 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1346614010704 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1346614010705 DNA-binding site [nucleotide binding]; DNA binding site 1346614010706 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1346614010707 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614010708 homodimer interface [polypeptide binding]; other site 1346614010709 catalytic residue [active] 1346614010710 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1346614010711 putative catalytic site [active] 1346614010712 putative metal binding site [ion binding]; other site 1346614010713 putative phosphate binding site [ion binding]; other site 1346614010714 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 1346614010715 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1346614010716 metal binding site [ion binding]; metal-binding site 1346614010717 dimer interface [polypeptide binding]; other site 1346614010718 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 1346614010719 transmembrane helices; other site 1346614010720 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1346614010721 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 1346614010722 ApbE family; Region: ApbE; pfam02424 1346614010723 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1346614010724 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 1346614010725 HlyD family secretion protein; Region: HlyD_3; pfam13437 1346614010726 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 1346614010727 Outer membrane efflux protein; Region: OEP; pfam02321 1346614010728 Outer membrane efflux protein; Region: OEP; pfam02321 1346614010729 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 1346614010730 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 1346614010731 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1346614010732 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1346614010733 dimer interface [polypeptide binding]; other site 1346614010734 active site 1346614010735 Uncharacterized conserved protein [Function unknown]; Region: COG4121 1346614010736 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 1346614010737 YfcL protein; Region: YfcL; pfam08891 1346614010738 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 1346614010739 hypothetical protein; Provisional; Region: PRK10621 1346614010740 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1346614010741 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 1346614010742 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 1346614010743 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1346614010744 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1346614010745 Tetramer interface [polypeptide binding]; other site 1346614010746 active site 1346614010747 FMN-binding site [chemical binding]; other site 1346614010748 HemK family putative methylases; Region: hemK_fam; TIGR00536 1346614010749 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614010750 S-adenosylmethionine binding site [chemical binding]; other site 1346614010751 hypothetical protein; Provisional; Region: PRK04946 1346614010752 Smr domain; Region: Smr; pfam01713 1346614010753 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1346614010754 catalytic core [active] 1346614010755 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1346614010756 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1346614010757 substrate binding site [chemical binding]; other site 1346614010758 oxyanion hole (OAH) forming residues; other site 1346614010759 trimer interface [polypeptide binding]; other site 1346614010760 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1346614010761 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1346614010762 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1346614010763 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 1346614010764 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1346614010765 dimer interface [polypeptide binding]; other site 1346614010766 active site 1346614010767 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 1346614010768 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 1346614010769 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 1346614010770 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 1346614010771 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 1346614010772 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1346614010773 binding surface 1346614010774 TPR motif; other site 1346614010775 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 1346614010776 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 1346614010777 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1346614010778 catalytic residues [active] 1346614010779 central insert; other site 1346614010780 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 1346614010781 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 1346614010782 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 1346614010783 heme exporter protein CcmC; Region: ccmC; TIGR01191 1346614010784 heme exporter protein CcmB; Region: ccmB; TIGR01190 1346614010785 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 1346614010786 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 1346614010787 Walker A/P-loop; other site 1346614010788 ATP binding site [chemical binding]; other site 1346614010789 Q-loop/lid; other site 1346614010790 ABC transporter signature motif; other site 1346614010791 Walker B; other site 1346614010792 D-loop; other site 1346614010793 H-loop/switch region; other site 1346614010794 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1346614010795 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 1346614010796 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1346614010797 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1346614010798 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1346614010799 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1346614010800 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1346614010801 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1346614010802 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 1346614010803 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1346614010804 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1346614010805 ATP binding site [chemical binding]; other site 1346614010806 putative Mg++ binding site [ion binding]; other site 1346614010807 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 1346614010808 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 1346614010809 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614010810 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1346614010811 dimerization interface [polypeptide binding]; other site 1346614010812 substrate binding pocket [chemical binding]; other site 1346614010813 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1346614010814 EamA-like transporter family; Region: EamA; pfam00892 1346614010815 EamA-like transporter family; Region: EamA; pfam00892 1346614010816 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1346614010817 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1346614010818 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1346614010819 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1346614010820 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1346614010821 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1346614010822 aminotransferase; Validated; Region: PRK08175 1346614010823 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1346614010824 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614010825 homodimer interface [polypeptide binding]; other site 1346614010826 catalytic residue [active] 1346614010827 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1346614010828 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1346614010829 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 1346614010830 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1346614010831 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1346614010832 GAF domain; Region: GAF; pfam01590 1346614010833 Histidine kinase; Region: His_kinase; pfam06580 1346614010834 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614010835 ATP binding site [chemical binding]; other site 1346614010836 Mg2+ binding site [ion binding]; other site 1346614010837 G-X-G motif; other site 1346614010838 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1346614010839 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614010840 active site 1346614010841 phosphorylation site [posttranslational modification] 1346614010842 intermolecular recognition site; other site 1346614010843 dimerization interface [polypeptide binding]; other site 1346614010844 LytTr DNA-binding domain; Region: LytTR; pfam04397 1346614010845 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1346614010846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614010847 putative substrate translocation pore; other site 1346614010848 glucokinase; Provisional; Region: glk; PRK00292 1346614010849 glucokinase, proteobacterial type; Region: glk; TIGR00749 1346614010850 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1346614010851 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1346614010852 Cl- selectivity filter; other site 1346614010853 Cl- binding residues [ion binding]; other site 1346614010854 pore gating glutamate residue; other site 1346614010855 dimer interface [polypeptide binding]; other site 1346614010856 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1346614010857 aspartate racemase; Region: asp_race; TIGR00035 1346614010858 Predicted membrane protein [Function unknown]; Region: COG4125 1346614010859 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1346614010860 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1346614010861 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614010862 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614010863 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1346614010864 dimerization interface [polypeptide binding]; other site 1346614010865 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 1346614010866 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1346614010867 dimer interface [polypeptide binding]; other site 1346614010868 PYR/PP interface [polypeptide binding]; other site 1346614010869 TPP binding site [chemical binding]; other site 1346614010870 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1346614010871 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1346614010872 TPP-binding site [chemical binding]; other site 1346614010873 dimer interface [polypeptide binding]; other site 1346614010874 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1346614010875 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1346614010876 active site 1346614010877 catalytic tetrad [active] 1346614010878 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 1346614010879 manganese transport protein MntH; Reviewed; Region: PRK00701 1346614010880 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1346614010881 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1346614010882 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1346614010883 Nucleoside recognition; Region: Gate; pfam07670 1346614010884 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1346614010885 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1346614010886 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1346614010887 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1346614010888 active site 1346614010889 HIGH motif; other site 1346614010890 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1346614010891 active site 1346614010892 KMSKS motif; other site 1346614010893 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1346614010894 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 1346614010895 putative NAD(P) binding site [chemical binding]; other site 1346614010896 active site 1346614010897 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1346614010898 hydrophobic substrate binding pocket; other site 1346614010899 Isochorismatase family; Region: Isochorismatase; pfam00857 1346614010900 active site 1346614010901 conserved cis-peptide bond; other site 1346614010902 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1346614010903 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 1346614010904 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1346614010905 acyl-activating enzyme (AAE) consensus motif; other site 1346614010906 active site 1346614010907 AMP binding site [chemical binding]; other site 1346614010908 substrate binding site [chemical binding]; other site 1346614010909 isochorismate synthase EntC; Provisional; Region: PRK15016 1346614010910 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1346614010911 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 1346614010912 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1346614010913 siderophore binding site; other site 1346614010914 enterobactin exporter EntS; Provisional; Region: PRK10489 1346614010915 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614010916 putative substrate translocation pore; other site 1346614010917 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1346614010918 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1346614010919 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1346614010920 ABC-ATPase subunit interface; other site 1346614010921 dimer interface [polypeptide binding]; other site 1346614010922 putative PBP binding regions; other site 1346614010923 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1346614010924 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1346614010925 ABC-ATPase subunit interface; other site 1346614010926 dimer interface [polypeptide binding]; other site 1346614010927 putative PBP binding regions; other site 1346614010928 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 1346614010929 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1346614010930 Walker A/P-loop; other site 1346614010931 ATP binding site [chemical binding]; other site 1346614010932 Q-loop/lid; other site 1346614010933 ABC transporter signature motif; other site 1346614010934 Walker B; other site 1346614010935 D-loop; other site 1346614010936 H-loop/switch region; other site 1346614010937 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1346614010938 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1346614010939 acyl-activating enzyme (AAE) consensus motif; other site 1346614010940 AMP binding site [chemical binding]; other site 1346614010941 MbtH-like protein; Region: MbtH; cl01279 1346614010942 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 1346614010943 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1346614010944 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1346614010945 outer membrane receptor FepA; Provisional; Region: PRK13524 1346614010946 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1346614010947 N-terminal plug; other site 1346614010948 ligand-binding site [chemical binding]; other site 1346614010949 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1346614010950 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1346614010951 peptide binding site [polypeptide binding]; other site 1346614010952 acetolactate synthase; Reviewed; Region: PRK08617 1346614010953 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1346614010954 PYR/PP interface [polypeptide binding]; other site 1346614010955 dimer interface [polypeptide binding]; other site 1346614010956 TPP binding site [chemical binding]; other site 1346614010957 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1346614010958 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1346614010959 TPP-binding site [chemical binding]; other site 1346614010960 dimer interface [polypeptide binding]; other site 1346614010961 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 1346614010962 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614010963 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614010964 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1346614010965 putative effector binding pocket; other site 1346614010966 dimerization interface [polypeptide binding]; other site 1346614010967 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 1346614010968 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 1346614010969 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1346614010970 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 1346614010971 FlxA-like protein; Region: FlxA; pfam14282 1346614010972 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614010973 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614010974 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1346614010975 putative dimerization interface [polypeptide binding]; other site 1346614010976 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1346614010977 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1346614010978 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 1346614010979 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1346614010980 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1346614010981 nucleotide binding pocket [chemical binding]; other site 1346614010982 K-X-D-G motif; other site 1346614010983 catalytic site [active] 1346614010984 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1346614010985 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1346614010986 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 1346614010987 DNA binding site [nucleotide binding] 1346614010988 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1346614010989 Dimer interface [polypeptide binding]; other site 1346614010990 BRCT sequence motif; other site 1346614010991 cell division protein ZipA; Provisional; Region: PRK03427 1346614010992 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 1346614010993 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 1346614010994 FtsZ protein binding site [polypeptide binding]; other site 1346614010995 putative sulfate transport protein CysZ; Validated; Region: PRK04949 1346614010996 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1346614010997 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1346614010998 dimer interface [polypeptide binding]; other site 1346614010999 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614011000 catalytic residue [active] 1346614011001 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1346614011002 dimerization domain swap beta strand [polypeptide binding]; other site 1346614011003 regulatory protein interface [polypeptide binding]; other site 1346614011004 active site 1346614011005 regulatory phosphorylation site [posttranslational modification]; other site 1346614011006 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 1346614011007 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1346614011008 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1346614011009 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1346614011010 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1346614011011 HPr interaction site; other site 1346614011012 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1346614011013 active site 1346614011014 phosphorylation site [posttranslational modification] 1346614011015 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1346614011016 dimerization interface [polypeptide binding]; other site 1346614011017 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1346614011018 dimer interface [polypeptide binding]; other site 1346614011019 phosphorylation site [posttranslational modification] 1346614011020 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614011021 ATP binding site [chemical binding]; other site 1346614011022 Mg2+ binding site [ion binding]; other site 1346614011023 G-X-G motif; other site 1346614011024 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1346614011025 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614011026 active site 1346614011027 phosphorylation site [posttranslational modification] 1346614011028 intermolecular recognition site; other site 1346614011029 dimerization interface [polypeptide binding]; other site 1346614011030 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1346614011031 DNA binding site [nucleotide binding] 1346614011032 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1346614011033 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1346614011034 HlyD family secretion protein; Region: HlyD_3; pfam13437 1346614011035 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1346614011036 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1346614011037 Walker A/P-loop; other site 1346614011038 ATP binding site [chemical binding]; other site 1346614011039 Q-loop/lid; other site 1346614011040 ABC transporter signature motif; other site 1346614011041 Walker B; other site 1346614011042 D-loop; other site 1346614011043 H-loop/switch region; other site 1346614011044 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1346614011045 FtsX-like permease family; Region: FtsX; pfam02687 1346614011046 cysteine synthase B; Region: cysM; TIGR01138 1346614011047 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1346614011048 dimer interface [polypeptide binding]; other site 1346614011049 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614011050 catalytic residue [active] 1346614011051 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 1346614011052 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1346614011053 Walker A/P-loop; other site 1346614011054 ATP binding site [chemical binding]; other site 1346614011055 Q-loop/lid; other site 1346614011056 ABC transporter signature motif; other site 1346614011057 Walker B; other site 1346614011058 D-loop; other site 1346614011059 H-loop/switch region; other site 1346614011060 TOBE-like domain; Region: TOBE_3; pfam12857 1346614011061 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1346614011062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614011063 dimer interface [polypeptide binding]; other site 1346614011064 conserved gate region; other site 1346614011065 putative PBP binding loops; other site 1346614011066 ABC-ATPase subunit interface; other site 1346614011067 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1346614011068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614011069 dimer interface [polypeptide binding]; other site 1346614011070 conserved gate region; other site 1346614011071 putative PBP binding loops; other site 1346614011072 ABC-ATPase subunit interface; other site 1346614011073 thiosulfate transporter subunit; Provisional; Region: PRK10852 1346614011074 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1346614011075 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1346614011076 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 1346614011077 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 1346614011078 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 1346614011079 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 1346614011080 putative acetyltransferase; Provisional; Region: PRK03624 1346614011081 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614011082 Coenzyme A binding pocket [chemical binding]; other site 1346614011083 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 1346614011084 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1346614011085 active site 1346614011086 metal binding site [ion binding]; metal-binding site 1346614011087 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1346614011088 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1346614011089 hypothetical protein; Validated; Region: PRK00124 1346614011090 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1346614011091 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1346614011092 N-terminal plug; other site 1346614011093 ligand-binding site [chemical binding]; other site 1346614011094 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1346614011095 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1346614011096 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1346614011097 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1346614011098 Protein of unknown function, DUF399; Region: DUF399; pfam04187 1346614011099 S-methylmethionine transporter; Provisional; Region: PRK11387 1346614011100 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1346614011101 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1346614011102 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1346614011103 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1346614011104 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1346614011105 putative NAD(P) binding site [chemical binding]; other site 1346614011106 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1346614011107 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 1346614011108 Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106 1346614011109 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1346614011110 Glyco_18 domain; Region: Glyco_18; smart00636 1346614011111 active site 1346614011112 Cellulose-binding domain, chitinase and related proteins; Region: CBD_like; cd12204 1346614011113 ligand binding site [chemical binding]; other site 1346614011114 chromosome replication initiation inhibitor protein; Provisional; Region: PRK13348 1346614011115 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614011116 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1346614011117 dimerization interface [polypeptide binding]; other site 1346614011118 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1346614011119 transaldolase-like protein; Provisional; Region: PTZ00411 1346614011120 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1346614011121 active site 1346614011122 dimer interface [polypeptide binding]; other site 1346614011123 catalytic residue [active] 1346614011124 transketolase; Reviewed; Region: PRK12753 1346614011125 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1346614011126 TPP-binding site [chemical binding]; other site 1346614011127 dimer interface [polypeptide binding]; other site 1346614011128 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1346614011129 PYR/PP interface [polypeptide binding]; other site 1346614011130 dimer interface [polypeptide binding]; other site 1346614011131 TPP binding site [chemical binding]; other site 1346614011132 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1346614011133 urease accessory protein UreE; Provisional; Region: ureE; PRK14711 1346614011134 UreE urease accessory protein, N-terminal domain; Region: UreE_N; pfam02814 1346614011135 dimer interface [polypeptide binding]; other site 1346614011136 catalytic residues [active] 1346614011137 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1346614011138 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614011139 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614011140 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1346614011141 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1346614011142 dimer interface [polypeptide binding]; other site 1346614011143 ADP-ribose binding site [chemical binding]; other site 1346614011144 active site 1346614011145 nudix motif; other site 1346614011146 metal binding site [ion binding]; metal-binding site 1346614011147 cytochrome c-type protein NapC; Provisional; Region: PRK10617 1346614011148 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 1346614011149 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 1346614011150 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 1346614011151 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1346614011152 [4Fe-4S] binding site [ion binding]; other site 1346614011153 molybdopterin cofactor binding site; other site 1346614011154 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1346614011155 molybdopterin cofactor binding site; other site 1346614011156 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 1346614011157 ferredoxin-type protein; Provisional; Region: PRK10194 1346614011158 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1346614011159 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 1346614011160 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1346614011161 HAMP domain; Region: HAMP; pfam00672 1346614011162 Histidine kinase; Region: HisKA_3; pfam07730 1346614011163 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614011164 ATP binding site [chemical binding]; other site 1346614011165 Mg2+ binding site [ion binding]; other site 1346614011166 G-X-G motif; other site 1346614011167 transcriptional regulator NarP; Provisional; Region: PRK10403 1346614011168 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614011169 active site 1346614011170 phosphorylation site [posttranslational modification] 1346614011171 intermolecular recognition site; other site 1346614011172 dimerization interface [polypeptide binding]; other site 1346614011173 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1346614011174 DNA binding residues [nucleotide binding] 1346614011175 dimerization interface [polypeptide binding]; other site 1346614011176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4519 1346614011177 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 1346614011178 Protein export membrane protein; Region: SecD_SecF; cl14618 1346614011179 putative outer membrane receptor; Provisional; Region: PRK13513 1346614011180 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1346614011181 N-terminal plug; other site 1346614011182 ligand-binding site [chemical binding]; other site 1346614011183 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1346614011184 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1346614011185 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1346614011186 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1346614011187 N-terminal plug; other site 1346614011188 ligand-binding site [chemical binding]; other site 1346614011189 Tetratrico peptide repeat; Region: TPR_5; pfam12688 1346614011190 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1346614011191 binding surface 1346614011192 TPR motif; other site 1346614011193 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614011194 Coenzyme A binding pocket [chemical binding]; other site 1346614011195 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1346614011196 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1346614011197 ArsC family; Region: ArsC; pfam03960 1346614011198 putative catalytic residues [active] 1346614011199 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1346614011200 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1346614011201 metal binding site [ion binding]; metal-binding site 1346614011202 dimer interface [polypeptide binding]; other site 1346614011203 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1346614011204 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1346614011205 Uncharacterized protein family (UPF0370); Region: UPF0370; pfam13980 1346614011206 putative hydrolase; Provisional; Region: PRK11460 1346614011207 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1346614011208 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 1346614011209 Helicase; Region: Helicase_RecD; pfam05127 1346614011210 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1346614011211 Predicted metalloprotease [General function prediction only]; Region: COG2321 1346614011212 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1346614011213 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1346614011214 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1346614011215 ATP binding site [chemical binding]; other site 1346614011216 active site 1346614011217 substrate binding site [chemical binding]; other site 1346614011218 lipoprotein; Provisional; Region: PRK11679 1346614011219 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 1346614011220 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1346614011221 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1346614011222 dimer interface [polypeptide binding]; other site 1346614011223 active site 1346614011224 catalytic residue [active] 1346614011225 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 1346614011226 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 1346614011227 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1346614011228 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1346614011229 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1346614011230 catalytic triad [active] 1346614011231 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1346614011232 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1346614011233 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1346614011234 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1346614011235 N-terminal plug; other site 1346614011236 ligand-binding site [chemical binding]; other site 1346614011237 PQQ-like domain; Region: PQQ_2; pfam13360 1346614011238 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1346614011239 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1346614011240 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1346614011241 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1346614011242 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1346614011243 putative DNA binding site [nucleotide binding]; other site 1346614011244 putative Zn2+ binding site [ion binding]; other site 1346614011245 AsnC family; Region: AsnC_trans_reg; pfam01037 1346614011246 Protein of unknown function (DUF2767); Region: DUF2767; cl08104 1346614011247 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1346614011248 Predicted transcriptional regulator [Transcription]; Region: COG1959 1346614011249 Transcriptional regulator; Region: Rrf2; pfam02082 1346614011250 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1346614011251 Peptidase family M48; Region: Peptidase_M48; pfam01435 1346614011252 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1346614011253 ArsC family; Region: ArsC; pfam03960 1346614011254 catalytic residues [active] 1346614011255 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1346614011256 DNA replication initiation factor; Provisional; Region: PRK08084 1346614011257 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1346614011258 hypothetical protein; Provisional; Region: PRK10457 1346614011259 uracil transporter; Provisional; Region: PRK10720 1346614011260 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1346614011261 active site 1346614011262 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1346614011263 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1346614011264 dimerization interface [polypeptide binding]; other site 1346614011265 putative ATP binding site [chemical binding]; other site 1346614011266 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1346614011267 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1346614011268 active site 1346614011269 substrate binding site [chemical binding]; other site 1346614011270 cosubstrate binding site; other site 1346614011271 catalytic site [active] 1346614011272 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 1346614011273 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614011274 Coenzyme A binding pocket [chemical binding]; other site 1346614011275 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 1346614011276 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1346614011277 Walker A/P-loop; other site 1346614011278 ATP binding site [chemical binding]; other site 1346614011279 Q-loop/lid; other site 1346614011280 ABC transporter signature motif; other site 1346614011281 Walker B; other site 1346614011282 D-loop; other site 1346614011283 H-loop/switch region; other site 1346614011284 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 1346614011285 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1346614011286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614011287 dimer interface [polypeptide binding]; other site 1346614011288 conserved gate region; other site 1346614011289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1346614011290 ABC-ATPase subunit interface; other site 1346614011291 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 1346614011292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614011293 conserved gate region; other site 1346614011294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614011295 conserved gate region; other site 1346614011296 putative PBP binding loops; other site 1346614011297 ABC-ATPase subunit interface; other site 1346614011298 polyphosphate kinase; Provisional; Region: PRK05443 1346614011299 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1346614011300 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1346614011301 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1346614011302 putative active site [active] 1346614011303 catalytic site [active] 1346614011304 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 1346614011305 domain interface [polypeptide binding]; other site 1346614011306 active site 1346614011307 catalytic site [active] 1346614011308 exopolyphosphatase; Provisional; Region: PRK10854 1346614011309 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1346614011310 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1346614011311 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1346614011312 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 1346614011313 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1346614011314 MgtE intracellular N domain; Region: MgtE_N; smart00924 1346614011315 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1346614011316 Divalent cation transporter; Region: MgtE; pfam01769 1346614011317 putative diguanylate cyclase; Provisional; Region: PRK09776 1346614011318 MASE1; Region: MASE1; cl17823 1346614011319 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1346614011320 putative active site [active] 1346614011321 heme pocket [chemical binding]; other site 1346614011322 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1346614011323 putative active site [active] 1346614011324 heme pocket [chemical binding]; other site 1346614011325 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1346614011326 putative active site [active] 1346614011327 heme pocket [chemical binding]; other site 1346614011328 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1346614011329 metal binding site [ion binding]; metal-binding site 1346614011330 active site 1346614011331 I-site; other site 1346614011332 EAL domain; Region: EAL; pfam00563 1346614011333 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 1346614011334 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1346614011335 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1346614011336 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614011337 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1346614011338 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 1346614011339 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1346614011340 minor groove reading motif; other site 1346614011341 helix-hairpin-helix signature motif; other site 1346614011342 substrate binding pocket [chemical binding]; other site 1346614011343 active site 1346614011344 putative chaperone; Provisional; Region: PRK11678 1346614011345 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1346614011346 nucleotide binding site [chemical binding]; other site 1346614011347 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1346614011348 SBD interface [polypeptide binding]; other site 1346614011349 Predicted kinase [General function prediction only]; Region: COG0645 1346614011350 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1346614011351 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1346614011352 active site 1346614011353 catalytic tetrad [active] 1346614011354 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 1346614011355 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1346614011356 HlyD family secretion protein; Region: HlyD_3; pfam13437 1346614011357 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1346614011358 Protein export membrane protein; Region: SecD_SecF; cl14618 1346614011359 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1346614011360 putative transporter; Provisional; Region: PRK10504 1346614011361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614011362 putative substrate translocation pore; other site 1346614011363 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 1346614011364 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1346614011365 dimerization interface [polypeptide binding]; other site 1346614011366 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1346614011367 dimer interface [polypeptide binding]; other site 1346614011368 phosphorylation site [posttranslational modification] 1346614011369 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614011370 ATP binding site [chemical binding]; other site 1346614011371 Mg2+ binding site [ion binding]; other site 1346614011372 G-X-G motif; other site 1346614011373 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 1346614011374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614011375 active site 1346614011376 phosphorylation site [posttranslational modification] 1346614011377 intermolecular recognition site; other site 1346614011378 dimerization interface [polypeptide binding]; other site 1346614011379 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1346614011380 DNA binding site [nucleotide binding] 1346614011381 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1346614011382 oligomeric interface; other site 1346614011383 putative active site [active] 1346614011384 homodimer interface [polypeptide binding]; other site 1346614011385 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 1346614011386 Uncharacterized conserved protein [Function unknown]; Region: COG3422 1346614011387 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 1346614011388 putative protease; Provisional; Region: PRK15452 1346614011389 Peptidase family U32; Region: Peptidase_U32; pfam01136 1346614011390 lipid kinase; Reviewed; Region: PRK13054 1346614011391 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1346614011392 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 1346614011393 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 1346614011394 putative active site pocket [active] 1346614011395 putative metal binding site [ion binding]; other site 1346614011396 putative oxidoreductase; Provisional; Region: PRK10083 1346614011397 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1346614011398 putative NAD(P) binding site [chemical binding]; other site 1346614011399 catalytic Zn binding site [ion binding]; other site 1346614011400 structural Zn binding site [ion binding]; other site 1346614011401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614011402 D-galactonate transporter; Region: 2A0114; TIGR00893 1346614011403 putative substrate translocation pore; other site 1346614011404 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1346614011405 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1346614011406 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1346614011407 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 1346614011408 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1346614011409 DNA-binding site [nucleotide binding]; DNA binding site 1346614011410 FCD domain; Region: FCD; pfam07729 1346614011411 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 1346614011412 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1346614011413 putative active site; other site 1346614011414 catalytic residue [active] 1346614011415 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 1346614011416 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 1346614011417 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1346614011418 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1346614011419 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 1346614011420 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 1346614011421 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 1346614011422 putative NAD(P) binding site [chemical binding]; other site 1346614011423 active site 1346614011424 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 1346614011425 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 1346614011426 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1346614011427 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1346614011428 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 1346614011429 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1346614011430 putative active site [active] 1346614011431 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1346614011432 O-methyltransferase; Region: Methyltransf_2; pfam00891 1346614011433 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816 1346614011434 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1346614011435 dimer interface [polypeptide binding]; other site 1346614011436 substrate binding site [chemical binding]; other site 1346614011437 ATP binding site [chemical binding]; other site 1346614011438 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1346614011439 substrate binding site [chemical binding]; other site 1346614011440 multimerization interface [polypeptide binding]; other site 1346614011441 ATP binding site [chemical binding]; other site 1346614011442 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1346614011443 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614011444 Coenzyme A binding pocket [chemical binding]; other site 1346614011445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614011446 putative substrate translocation pore; other site 1346614011447 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1346614011448 transcriptional regulator protein; Region: phnR; TIGR03337 1346614011449 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1346614011450 DNA-binding site [nucleotide binding]; DNA binding site 1346614011451 UTRA domain; Region: UTRA; pfam07702 1346614011452 Predicted transcriptional regulators [Transcription]; Region: COG1733 1346614011453 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1346614011454 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1346614011455 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1346614011456 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1346614011457 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1346614011458 RNA binding surface [nucleotide binding]; other site 1346614011459 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 1346614011460 probable active site [active] 1346614011461 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1346614011462 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 1346614011463 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1346614011464 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614011465 active site 1346614011466 phosphorylation site [posttranslational modification] 1346614011467 intermolecular recognition site; other site 1346614011468 dimerization interface [polypeptide binding]; other site 1346614011469 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1346614011470 DNA binding residues [nucleotide binding] 1346614011471 dimerization interface [polypeptide binding]; other site 1346614011472 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1346614011473 dimer interface [polypeptide binding]; other site 1346614011474 phosphorylation site [posttranslational modification] 1346614011475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614011476 ATP binding site [chemical binding]; other site 1346614011477 Mg2+ binding site [ion binding]; other site 1346614011478 G-X-G motif; other site 1346614011479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614011480 Response regulator receiver domain; Region: Response_reg; pfam00072 1346614011481 active site 1346614011482 phosphorylation site [posttranslational modification] 1346614011483 intermolecular recognition site; other site 1346614011484 dimerization interface [polypeptide binding]; other site 1346614011485 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1346614011486 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1346614011487 substrate binding site [chemical binding]; other site 1346614011488 oxyanion hole (OAH) forming residues; other site 1346614011489 trimer interface [polypeptide binding]; other site 1346614011490 Predicted transcriptional regulators [Transcription]; Region: COG1733 1346614011491 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1346614011492 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1346614011493 hypothetical protein; Provisional; Region: PRK06847 1346614011494 hypothetical protein; Provisional; Region: PRK07236 1346614011495 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1346614011496 benzoate transport; Region: 2A0115; TIGR00895 1346614011497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614011498 putative substrate translocation pore; other site 1346614011499 GMP synthase; Reviewed; Region: guaA; PRK00074 1346614011500 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1346614011501 AMP/PPi binding site [chemical binding]; other site 1346614011502 candidate oxyanion hole; other site 1346614011503 catalytic triad [active] 1346614011504 potential glutamine specificity residues [chemical binding]; other site 1346614011505 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1346614011506 ATP Binding subdomain [chemical binding]; other site 1346614011507 Ligand Binding sites [chemical binding]; other site 1346614011508 Dimerization subdomain; other site 1346614011509 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1346614011510 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1346614011511 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1346614011512 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1346614011513 active site 1346614011514 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1346614011515 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1346614011516 generic binding surface II; other site 1346614011517 generic binding surface I; other site 1346614011518 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1346614011519 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1346614011520 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 1346614011521 putative active site [active] 1346614011522 putative catalytic site [active] 1346614011523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614011524 D-galactonate transporter; Region: 2A0114; TIGR00893 1346614011525 putative substrate translocation pore; other site 1346614011526 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1346614011527 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1346614011528 DNA binding site [nucleotide binding] 1346614011529 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1346614011530 ligand binding site [chemical binding]; other site 1346614011531 dimerization interface [polypeptide binding]; other site 1346614011532 Immunity protein Imm2; Region: Imm2; pfam14426 1346614011533 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1346614011534 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1346614011535 Tumour suppressor, Mitostatin; Region: Trichoplein; pfam13868 1346614011536 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 1346614011537 The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424 1346614011538 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1346614011539 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1346614011540 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1346614011541 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 1346614011542 Predicted permeases [General function prediction only]; Region: COG0679 1346614011543 GTP-binding protein Der; Reviewed; Region: PRK00093 1346614011544 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1346614011545 G1 box; other site 1346614011546 GTP/Mg2+ binding site [chemical binding]; other site 1346614011547 Switch I region; other site 1346614011548 G2 box; other site 1346614011549 Switch II region; other site 1346614011550 G3 box; other site 1346614011551 G4 box; other site 1346614011552 G5 box; other site 1346614011553 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1346614011554 G1 box; other site 1346614011555 GTP/Mg2+ binding site [chemical binding]; other site 1346614011556 Switch I region; other site 1346614011557 G2 box; other site 1346614011558 G3 box; other site 1346614011559 Switch II region; other site 1346614011560 G4 box; other site 1346614011561 G5 box; other site 1346614011562 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 1346614011563 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 1346614011564 Trp docking motif [polypeptide binding]; other site 1346614011565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1346614011566 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1346614011567 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1346614011568 dimer interface [polypeptide binding]; other site 1346614011569 motif 1; other site 1346614011570 active site 1346614011571 motif 2; other site 1346614011572 motif 3; other site 1346614011573 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1346614011574 anticodon binding site; other site 1346614011575 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1346614011576 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1346614011577 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1346614011578 cytoskeletal protein RodZ; Provisional; Region: PRK10856 1346614011579 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1346614011580 non-specific DNA binding site [nucleotide binding]; other site 1346614011581 salt bridge; other site 1346614011582 sequence-specific DNA binding site [nucleotide binding]; other site 1346614011583 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1346614011584 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 1346614011585 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1346614011586 binding surface 1346614011587 TPR motif; other site 1346614011588 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1346614011589 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1346614011590 FeS/SAM binding site; other site 1346614011591 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1346614011592 active site 1346614011593 multimer interface [polypeptide binding]; other site 1346614011594 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1346614011595 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1346614011596 DNA binding site [nucleotide binding] 1346614011597 domain linker motif; other site 1346614011598 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1346614011599 dimerization interface (closed form) [polypeptide binding]; other site 1346614011600 ligand binding site [chemical binding]; other site 1346614011601 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 1346614011602 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1346614011603 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1346614011604 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614011605 homodimer interface [polypeptide binding]; other site 1346614011606 catalytic residue [active] 1346614011607 SseB protein; Region: SseB; pfam07179 1346614011608 aminopeptidase B; Provisional; Region: PRK05015 1346614011609 Peptidase; Region: DUF3663; pfam12404 1346614011610 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1346614011611 interface (dimer of trimers) [polypeptide binding]; other site 1346614011612 Substrate-binding/catalytic site; other site 1346614011613 Zn-binding sites [ion binding]; other site 1346614011614 hypothetical protein; Provisional; Region: PRK10721 1346614011615 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1346614011616 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1346614011617 catalytic loop [active] 1346614011618 iron binding site [ion binding]; other site 1346614011619 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1346614011620 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 1346614011621 nucleotide binding site [chemical binding]; other site 1346614011622 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1346614011623 SBD interface [polypeptide binding]; other site 1346614011624 co-chaperone HscB; Provisional; Region: hscB; PRK05014 1346614011625 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1346614011626 HSP70 interaction site [polypeptide binding]; other site 1346614011627 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 1346614011628 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 1346614011629 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1346614011630 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1346614011631 trimerization site [polypeptide binding]; other site 1346614011632 active site 1346614011633 cysteine desulfurase; Provisional; Region: PRK14012 1346614011634 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1346614011635 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1346614011636 catalytic residue [active] 1346614011637 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 1346614011638 Rrf2 family protein; Region: rrf2_super; TIGR00738 1346614011639 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 1346614011640 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1346614011641 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1346614011642 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1346614011643 active site 1346614011644 dimerization interface [polypeptide binding]; other site 1346614011645 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 1346614011646 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 1346614011647 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 1346614011648 PRD domain; Region: PRD; pfam00874 1346614011649 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1346614011650 MFS_1 like family; Region: MFS_1_like; pfam12832 1346614011651 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1346614011652 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1346614011653 dimer interface [polypeptide binding]; other site 1346614011654 active site 1346614011655 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1346614011656 folate binding site [chemical binding]; other site 1346614011657 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1346614011658 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1346614011659 heme-binding site [chemical binding]; other site 1346614011660 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1346614011661 FAD binding pocket [chemical binding]; other site 1346614011662 FAD binding motif [chemical binding]; other site 1346614011663 phosphate binding motif [ion binding]; other site 1346614011664 beta-alpha-beta structure motif; other site 1346614011665 NAD binding pocket [chemical binding]; other site 1346614011666 Heme binding pocket [chemical binding]; other site 1346614011667 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1346614011668 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1346614011669 Cytochrome c; Region: Cytochrom_C; pfam00034 1346614011670 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1346614011671 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1346614011672 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1346614011673 tetrameric interface [polypeptide binding]; other site 1346614011674 NAD binding site [chemical binding]; other site 1346614011675 catalytic residues [active] 1346614011676 substrate binding site [chemical binding]; other site 1346614011677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1346614011678 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1346614011679 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614011680 dimer interface [polypeptide binding]; other site 1346614011681 conserved gate region; other site 1346614011682 putative PBP binding loops; other site 1346614011683 ABC-ATPase subunit interface; other site 1346614011684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614011685 dimer interface [polypeptide binding]; other site 1346614011686 putative PBP binding loops; other site 1346614011687 ABC-ATPase subunit interface; other site 1346614011688 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1346614011689 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1346614011690 Walker A/P-loop; other site 1346614011691 ATP binding site [chemical binding]; other site 1346614011692 Q-loop/lid; other site 1346614011693 ABC transporter signature motif; other site 1346614011694 Walker B; other site 1346614011695 D-loop; other site 1346614011696 H-loop/switch region; other site 1346614011697 TOBE domain; Region: TOBE_2; pfam08402 1346614011698 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1346614011699 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1346614011700 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1346614011701 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1346614011702 tetrameric interface [polypeptide binding]; other site 1346614011703 NAD binding site [chemical binding]; other site 1346614011704 catalytic residues [active] 1346614011705 substrate binding site [chemical binding]; other site 1346614011706 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614011707 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614011708 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 1346614011709 putative substrate binding pocket [chemical binding]; other site 1346614011710 dimerization interface [polypeptide binding]; other site 1346614011711 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 1346614011712 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1346614011713 NAD synthetase; Provisional; Region: PRK13981 1346614011714 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1346614011715 multimer interface [polypeptide binding]; other site 1346614011716 active site 1346614011717 catalytic triad [active] 1346614011718 protein interface 1 [polypeptide binding]; other site 1346614011719 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1346614011720 homodimer interface [polypeptide binding]; other site 1346614011721 NAD binding pocket [chemical binding]; other site 1346614011722 ATP binding pocket [chemical binding]; other site 1346614011723 Mg binding site [ion binding]; other site 1346614011724 active-site loop [active] 1346614011725 response regulator GlrR; Provisional; Region: PRK15115 1346614011726 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614011727 active site 1346614011728 phosphorylation site [posttranslational modification] 1346614011729 intermolecular recognition site; other site 1346614011730 dimerization interface [polypeptide binding]; other site 1346614011731 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1346614011732 Walker A motif; other site 1346614011733 ATP binding site [chemical binding]; other site 1346614011734 Walker B motif; other site 1346614011735 arginine finger; other site 1346614011736 hypothetical protein; Provisional; Region: PRK10722 1346614011737 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1346614011738 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1346614011739 dimer interface [polypeptide binding]; other site 1346614011740 phosphorylation site [posttranslational modification] 1346614011741 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614011742 ATP binding site [chemical binding]; other site 1346614011743 Mg2+ binding site [ion binding]; other site 1346614011744 G-X-G motif; other site 1346614011745 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1346614011746 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1346614011747 dimerization interface [polypeptide binding]; other site 1346614011748 ATP binding site [chemical binding]; other site 1346614011749 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1346614011750 dimerization interface [polypeptide binding]; other site 1346614011751 ATP binding site [chemical binding]; other site 1346614011752 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1346614011753 putative active site [active] 1346614011754 catalytic triad [active] 1346614011755 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 1346614011756 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1346614011757 substrate binding pocket [chemical binding]; other site 1346614011758 membrane-bound complex binding site; other site 1346614011759 hinge residues; other site 1346614011760 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1346614011761 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1346614011762 catalytic residue [active] 1346614011763 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1346614011764 nucleoside/Zn binding site; other site 1346614011765 dimer interface [polypeptide binding]; other site 1346614011766 catalytic motif [active] 1346614011767 putative alcohol dehydrogenase; Provisional; Region: PRK09860 1346614011768 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1346614011769 dimer interface [polypeptide binding]; other site 1346614011770 active site 1346614011771 metal binding site [ion binding]; metal-binding site 1346614011772 hypothetical protein; Provisional; Region: PRK11590 1346614011773 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1346614011774 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1346614011775 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1346614011776 active site turn [active] 1346614011777 phosphorylation site [posttranslational modification] 1346614011778 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1346614011779 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1346614011780 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1346614011781 putative active site [active] 1346614011782 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 1346614011783 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1346614011784 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1346614011785 putative active site [active] 1346614011786 DinI-like family; Region: DinI; cl11630 1346614011787 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 1346614011788 Phage-related protein, tail component [Function unknown]; Region: COG4723 1346614011789 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 1346614011790 MPN+ (JAMM) motif; other site 1346614011791 Zinc-binding site [ion binding]; other site 1346614011792 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1346614011793 NlpC/P60 family; Region: NLPC_P60; cl17555 1346614011794 Phage-related protein [Function unknown]; Region: gp18; COG4672 1346614011795 Phage minor tail protein; Region: Phage_min_tail; pfam05939 1346614011796 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1346614011797 Immunoglobulin domain; Region: Ig_2; pfam13895 1346614011798 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 1346614011799 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 1346614011800 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1346614011801 oligomerization interface [polypeptide binding]; other site 1346614011802 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1346614011803 Phage capsid family; Region: Phage_capsid; pfam05065 1346614011804 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1346614011805 oligomer interface [polypeptide binding]; other site 1346614011806 active site residues [active] 1346614011807 Phage-related protein [Function unknown]; Region: COG4695 1346614011808 Phage portal protein; Region: Phage_portal; pfam04860 1346614011809 Phage Terminase; Region: Terminase_1; pfam03354 1346614011810 Domain of unknown function, E. rectale Gene description (DUF3877); Region: DUF3877; pfam12993 1346614011811 Phage terminase, small subunit; Region: Terminase_4; pfam05119 1346614011812 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1346614011813 active site 1346614011814 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1346614011815 catalytic residues [active] 1346614011816 DNA methylase; Region: N6_N4_Mtase; cl17433 1346614011817 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1346614011818 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1346614011819 DNA methylase; Region: N6_N4_Mtase; pfam01555 1346614011820 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 1346614011821 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1346614011822 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 1346614011823 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 1346614011824 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 1346614011825 Toprim domain; Region: Toprim_3; pfam13362 1346614011826 AAA domain; Region: AAA_22; pfam13401 1346614011827 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1346614011828 ATP binding site [chemical binding]; other site 1346614011829 putative Mg++ binding site [ion binding]; other site 1346614011830 nucleotide binding region [chemical binding]; other site 1346614011831 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 1346614011832 ATP-binding site [chemical binding]; other site 1346614011833 Predicted transcriptional regulator [Transcription]; Region: COG2932 1346614011834 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1346614011835 Catalytic site [active] 1346614011836 Uncharacterized conserved protein (DUF2303); Region: DUF2303; cl02338 1346614011837 ParB-like nuclease domain; Region: ParBc; cl02129 1346614011838 KorB domain; Region: KorB; pfam08535 1346614011839 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1346614011840 active site 1346614011841 substrate binding site [chemical binding]; other site 1346614011842 catalytic site [active] 1346614011843 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1346614011844 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1346614011845 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1346614011846 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1346614011847 active site 1346614011848 hydrophilic channel; other site 1346614011849 dimerization interface [polypeptide binding]; other site 1346614011850 catalytic residues [active] 1346614011851 active site lid [active] 1346614011852 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1346614011853 Recombination protein O N terminal; Region: RecO_N; pfam11967 1346614011854 Recombination protein O C terminal; Region: RecO_C; pfam02565 1346614011855 GTPase Era; Reviewed; Region: era; PRK00089 1346614011856 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1346614011857 G1 box; other site 1346614011858 GTP/Mg2+ binding site [chemical binding]; other site 1346614011859 Switch I region; other site 1346614011860 G2 box; other site 1346614011861 Switch II region; other site 1346614011862 G3 box; other site 1346614011863 G4 box; other site 1346614011864 G5 box; other site 1346614011865 KH domain; Region: KH_2; pfam07650 1346614011866 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 1346614011867 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1346614011868 dimerization interface [polypeptide binding]; other site 1346614011869 active site 1346614011870 metal binding site [ion binding]; metal-binding site 1346614011871 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1346614011872 dsRNA binding site [nucleotide binding]; other site 1346614011873 signal peptidase I; Provisional; Region: PRK10861 1346614011874 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1346614011875 Catalytic site [active] 1346614011876 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1346614011877 GTP-binding protein LepA; Provisional; Region: PRK05433 1346614011878 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1346614011879 G1 box; other site 1346614011880 putative GEF interaction site [polypeptide binding]; other site 1346614011881 GTP/Mg2+ binding site [chemical binding]; other site 1346614011882 Switch I region; other site 1346614011883 G2 box; other site 1346614011884 G3 box; other site 1346614011885 Switch II region; other site 1346614011886 G4 box; other site 1346614011887 G5 box; other site 1346614011888 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1346614011889 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1346614011890 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1346614011891 SoxR reducing system protein RseC; Provisional; Region: PRK10862 1346614011892 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1346614011893 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 1346614011894 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 1346614011895 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1346614011896 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 1346614011897 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 1346614011898 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1346614011899 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1346614011900 DNA binding residues [nucleotide binding] 1346614011901 L-aspartate oxidase; Provisional; Region: PRK09077 1346614011902 L-aspartate oxidase; Provisional; Region: PRK06175 1346614011903 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1346614011904 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1346614011905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614011906 S-adenosylmethionine binding site [chemical binding]; other site 1346614011907 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1346614011908 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1346614011909 ATP binding site [chemical binding]; other site 1346614011910 Mg++ binding site [ion binding]; other site 1346614011911 motif III; other site 1346614011912 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1346614011913 nucleotide binding region [chemical binding]; other site 1346614011914 ATP-binding site [chemical binding]; other site 1346614011915 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1346614011916 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1346614011917 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1346614011918 nucleophilic elbow; other site 1346614011919 catalytic triad; other site 1346614011920 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 1346614011921 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1346614011922 ligand binding site [chemical binding]; other site 1346614011923 active site 1346614011924 UGI interface [polypeptide binding]; other site 1346614011925 catalytic site [active] 1346614011926 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1346614011927 dimer interface [polypeptide binding]; other site 1346614011928 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1346614011929 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1346614011930 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 1346614011931 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1346614011932 recombination and repair protein; Provisional; Region: PRK10869 1346614011933 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1346614011934 Walker A/P-loop; other site 1346614011935 ATP binding site [chemical binding]; other site 1346614011936 Q-loop/lid; other site 1346614011937 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1346614011938 ABC transporter signature motif; other site 1346614011939 Walker B; other site 1346614011940 D-loop; other site 1346614011941 H-loop/switch region; other site 1346614011942 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 1346614011943 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1346614011944 hypothetical protein; Validated; Region: PRK01777 1346614011945 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1346614011946 putative coenzyme Q binding site [chemical binding]; other site 1346614011947 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1346614011948 SmpB-tmRNA interface; other site 1346614011949 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1346614011950 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1346614011951 HlyD family secretion protein; Region: HlyD_3; pfam13437 1346614011952 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 1346614011953 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1346614011954 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614011955 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614011956 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1346614011957 dimerization interface [polypeptide binding]; other site 1346614011958 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1346614011959 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 1346614011960 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614011961 Coenzyme A binding pocket [chemical binding]; other site 1346614011962 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614011963 S-adenosylmethionine binding site [chemical binding]; other site 1346614011964 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 1346614011965 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 1346614011966 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1346614011967 Predicted membrane protein [Function unknown]; Region: COG2259 1346614011968 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1346614011969 Smr domain; Region: Smr; pfam01713 1346614011970 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 1346614011971 hypothetical protein; Provisional; Region: PRK10556 1346614011972 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1346614011973 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614011974 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 1346614011975 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614011976 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614011977 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1346614011978 putative effector binding pocket; other site 1346614011979 dimerization interface [polypeptide binding]; other site 1346614011980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614011981 putative substrate translocation pore; other site 1346614011982 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614011983 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 1346614011984 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 1346614011985 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1346614011986 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1346614011987 DNA-binding site [nucleotide binding]; DNA binding site 1346614011988 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1346614011989 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614011990 homodimer interface [polypeptide binding]; other site 1346614011991 catalytic residue [active] 1346614011992 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1346614011993 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1346614011994 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1346614011995 catalytic residues [active] 1346614011996 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1346614011997 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1346614011998 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1346614011999 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1346614012000 active site 1346614012001 dimer interface [polypeptide binding]; other site 1346614012002 catalytic residues [active] 1346614012003 effector binding site; other site 1346614012004 R2 peptide binding site; other site 1346614012005 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1346614012006 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1346614012007 dimer interface [polypeptide binding]; other site 1346614012008 putative radical transfer pathway; other site 1346614012009 diiron center [ion binding]; other site 1346614012010 tyrosyl radical; other site 1346614012011 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 1346614012012 short chain dehydrogenase; Provisional; Region: PRK12937 1346614012013 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1346614012014 NADP binding site [chemical binding]; other site 1346614012015 homodimer interface [polypeptide binding]; other site 1346614012016 active site 1346614012017 substrate binding site [chemical binding]; other site 1346614012018 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614012019 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614012020 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1346614012021 putative effector binding pocket; other site 1346614012022 putative dimerization interface [polypeptide binding]; other site 1346614012023 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1346614012024 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 1346614012025 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 1346614012026 PAS domain; Region: PAS; smart00091 1346614012027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614012028 ATP binding site [chemical binding]; other site 1346614012029 Mg2+ binding site [ion binding]; other site 1346614012030 G-X-G motif; other site 1346614012031 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1346614012032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614012033 active site 1346614012034 phosphorylation site [posttranslational modification] 1346614012035 intermolecular recognition site; other site 1346614012036 dimerization interface [polypeptide binding]; other site 1346614012037 Transcriptional regulator; Region: CitT; pfam12431 1346614012038 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 1346614012039 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1346614012040 Walker A/P-loop; other site 1346614012041 ATP binding site [chemical binding]; other site 1346614012042 Q-loop/lid; other site 1346614012043 ABC transporter signature motif; other site 1346614012044 Walker B; other site 1346614012045 D-loop; other site 1346614012046 H-loop/switch region; other site 1346614012047 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1346614012048 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1346614012049 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614012050 dimer interface [polypeptide binding]; other site 1346614012051 conserved gate region; other site 1346614012052 putative PBP binding loops; other site 1346614012053 ABC-ATPase subunit interface; other site 1346614012054 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 1346614012055 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1346614012056 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 1346614012057 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1346614012058 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614012059 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614012060 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 1346614012061 putative dimerization interface [polypeptide binding]; other site 1346614012062 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1346614012063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614012064 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1346614012065 putative L-valine exporter; Provisional; Region: PRK10408 1346614012066 transcriptional repressor MprA; Provisional; Region: PRK10870 1346614012067 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1346614012068 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1346614012069 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 1346614012070 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1346614012071 HlyD family secretion protein; Region: HlyD_3; pfam13437 1346614012072 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1346614012073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614012074 putative substrate translocation pore; other site 1346614012075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614012076 putative methyltransferase; Provisional; Region: PRK10864 1346614012077 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1346614012078 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1346614012079 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1346614012080 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1346614012081 catalytic residues [active] 1346614012082 Uncharacterized conserved protein [Function unknown]; Region: COG3148 1346614012083 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1346614012084 CoA binding domain; Region: CoA_binding_2; pfam13380 1346614012085 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1346614012086 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1346614012087 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1346614012088 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614012089 Coenzyme A binding pocket [chemical binding]; other site 1346614012090 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 1346614012091 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 1346614012092 domain interface [polypeptide binding]; other site 1346614012093 putative active site [active] 1346614012094 catalytic site [active] 1346614012095 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 1346614012096 domain interface [polypeptide binding]; other site 1346614012097 putative active site [active] 1346614012098 catalytic site [active] 1346614012099 lipoprotein; Provisional; Region: PRK10759 1346614012100 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1346614012101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614012102 putative substrate translocation pore; other site 1346614012103 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 1346614012104 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1346614012105 active site 1346614012106 motif I; other site 1346614012107 motif II; other site 1346614012108 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1346614012109 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1346614012110 Walker A/P-loop; other site 1346614012111 ATP binding site [chemical binding]; other site 1346614012112 Q-loop/lid; other site 1346614012113 ABC transporter signature motif; other site 1346614012114 Walker B; other site 1346614012115 D-loop; other site 1346614012116 H-loop/switch region; other site 1346614012117 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1346614012118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614012119 dimer interface [polypeptide binding]; other site 1346614012120 conserved gate region; other site 1346614012121 ABC-ATPase subunit interface; other site 1346614012122 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 1346614012123 lipoprotein, YaeC family; Region: TIGR00363 1346614012124 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 1346614012125 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1346614012126 homodimer interaction site [polypeptide binding]; other site 1346614012127 cofactor binding site; other site 1346614012128 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1346614012129 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1346614012130 dimer interface [polypeptide binding]; other site 1346614012131 motif 1; other site 1346614012132 active site 1346614012133 motif 2; other site 1346614012134 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1346614012135 putative deacylase active site [active] 1346614012136 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1346614012137 active site 1346614012138 motif 3; other site 1346614012139 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1346614012140 anticodon binding site; other site 1346614012141 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 1346614012142 NlpE N-terminal domain; Region: NlpE; pfam04170 1346614012143 hypothetical protein; Provisional; Region: PRK09256 1346614012144 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1346614012145 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 1346614012146 hypothetical protein; Provisional; Region: PRK04964 1346614012147 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 1346614012148 Cytochrome c; Region: Cytochrom_C; cl11414 1346614012149 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 1346614012150 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1346614012151 TilS substrate binding domain; Region: TilS; pfam09179 1346614012152 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 1346614012153 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1346614012154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614012155 putative substrate translocation pore; other site 1346614012156 POT family; Region: PTR2; cl17359 1346614012157 lysine decarboxylase CadA; Provisional; Region: PRK15400 1346614012158 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1346614012159 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1346614012160 homodimer interface [polypeptide binding]; other site 1346614012161 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614012162 catalytic residue [active] 1346614012163 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1346614012164 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 1346614012165 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 1346614012166 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1346614012167 DNA binding site [nucleotide binding] 1346614012168 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1346614012169 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1346614012170 putative metal binding site [ion binding]; other site 1346614012171 Thioredoxin (TRX) superfamily; a large, diverse group of proteins containing a TRX-fold. Many members contain a classic TRX domain with a redox active CXXC motif. They function as protein disulfide oxidoreductases (PDOs), altering the redox state of...; Region: TRX_superfamily; cd01659 1346614012172 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1346614012173 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1346614012174 putative Zn2+ binding site [ion binding]; other site 1346614012175 putative DNA binding site [nucleotide binding]; other site 1346614012176 lysine decarboxylase LdcC; Provisional; Region: PRK15399 1346614012177 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1346614012178 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1346614012179 homodimer interface [polypeptide binding]; other site 1346614012180 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614012181 catalytic residue [active] 1346614012182 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1346614012183 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1346614012184 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1346614012185 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1346614012186 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1346614012187 putative active site [active] 1346614012188 putative PHP Thumb interface [polypeptide binding]; other site 1346614012189 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1346614012190 generic binding surface II; other site 1346614012191 generic binding surface I; other site 1346614012192 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1346614012193 RNA/DNA hybrid binding site [nucleotide binding]; other site 1346614012194 active site 1346614012195 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1346614012196 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1346614012197 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1346614012198 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1346614012199 active site 1346614012200 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1346614012201 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1346614012202 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1346614012203 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1346614012204 trimer interface [polypeptide binding]; other site 1346614012205 active site 1346614012206 UDP-GlcNAc binding site [chemical binding]; other site 1346614012207 lipid binding site [chemical binding]; lipid-binding site 1346614012208 periplasmic chaperone; Provisional; Region: PRK10780 1346614012209 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1346614012210 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 1346614012211 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1346614012212 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1346614012213 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1346614012214 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1346614012215 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1346614012216 Surface antigen; Region: Bac_surface_Ag; pfam01103 1346614012217 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1346614012218 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1346614012219 active site 1346614012220 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1346614012221 protein binding site [polypeptide binding]; other site 1346614012222 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1346614012223 protein binding site [polypeptide binding]; other site 1346614012224 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1346614012225 putative substrate binding region [chemical binding]; other site 1346614012226 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1346614012227 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1346614012228 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1346614012229 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1346614012230 catalytic residue [active] 1346614012231 putative FPP diphosphate binding site; other site 1346614012232 putative FPP binding hydrophobic cleft; other site 1346614012233 dimer interface [polypeptide binding]; other site 1346614012234 putative IPP diphosphate binding site; other site 1346614012235 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1346614012236 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1346614012237 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1346614012238 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1346614012239 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1346614012240 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1346614012241 hinge region; other site 1346614012242 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1346614012243 putative nucleotide binding site [chemical binding]; other site 1346614012244 uridine monophosphate binding site [chemical binding]; other site 1346614012245 homohexameric interface [polypeptide binding]; other site 1346614012246 elongation factor Ts; Provisional; Region: tsf; PRK09377 1346614012247 UBA/TS-N domain; Region: UBA; pfam00627 1346614012248 Elongation factor TS; Region: EF_TS; pfam00889 1346614012249 Elongation factor TS; Region: EF_TS; pfam00889 1346614012250 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1346614012251 rRNA interaction site [nucleotide binding]; other site 1346614012252 S8 interaction site; other site 1346614012253 putative laminin-1 binding site; other site 1346614012254 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1346614012255 active site 1346614012256 PII uridylyl-transferase; Provisional; Region: PRK05007 1346614012257 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1346614012258 metal binding triad; other site 1346614012259 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1346614012260 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1346614012261 Zn2+ binding site [ion binding]; other site 1346614012262 Mg2+ binding site [ion binding]; other site 1346614012263 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1346614012264 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1346614012265 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1346614012266 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1346614012267 trimer interface [polypeptide binding]; other site 1346614012268 active site 1346614012269 substrate binding site [chemical binding]; other site 1346614012270 CoA binding site [chemical binding]; other site 1346614012271 hypothetical protein; Provisional; Region: PRK13677 1346614012272 flavodoxin; Provisional; Region: PRK08105 1346614012273 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1346614012274 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 1346614012275 probable active site [active] 1346614012276 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 1346614012277 Transglycosylase; Region: Transgly; pfam00912 1346614012278 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1346614012279 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1346614012280 Bacterial Ig-like domain; Region: Big_5; pfam13205 1346614012281 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1346614012282 MG2 domain; Region: A2M_N; pfam01835 1346614012283 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1346614012284 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1346614012285 surface patch; other site 1346614012286 thioester region; other site 1346614012287 specificity defining residues; other site 1346614012288 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 1346614012289 SecY interacting protein Syd; Provisional; Region: PRK04968 1346614012290 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1346614012291 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 1346614012292 flap endonuclease-like protein; Provisional; Region: PRK09482 1346614012293 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1346614012294 active site 1346614012295 metal binding site 1 [ion binding]; metal-binding site 1346614012296 putative 5' ssDNA interaction site; other site 1346614012297 metal binding site 3; metal-binding site 1346614012298 metal binding site 2 [ion binding]; metal-binding site 1346614012299 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1346614012300 putative DNA binding site [nucleotide binding]; other site 1346614012301 putative metal binding site [ion binding]; other site 1346614012302 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 1346614012303 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1346614012304 hypothetical protein; Provisional; Region: PRK10873 1346614012305 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1346614012306 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614012307 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1346614012308 dimerization interface [polypeptide binding]; other site 1346614012309 substrate binding pocket [chemical binding]; other site 1346614012310 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1346614012311 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1346614012312 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1346614012313 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1346614012314 catalytic residue [active] 1346614012315 cysteine desulfurase, sulfur acceptor subunit CsdE; Region: FeS_syn_CsdE; TIGR03391 1346614012316 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 1346614012317 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1346614012318 putative ATP binding site [chemical binding]; other site 1346614012319 putative substrate interface [chemical binding]; other site 1346614012320 murein transglycosylase A; Provisional; Region: mltA; PRK11162 1346614012321 MltA specific insert domain; Region: MltA; smart00925 1346614012322 3D domain; Region: 3D; pfam06725 1346614012323 benzoate transport; Region: 2A0115; TIGR00895 1346614012324 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614012325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614012326 putative substrate translocation pore; other site 1346614012327 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1346614012328 N-acetylglutamate synthase; Validated; Region: PRK05279 1346614012329 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1346614012330 putative nucleotide binding site [chemical binding]; other site 1346614012331 putative substrate binding site [chemical binding]; other site 1346614012332 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614012333 Coenzyme A binding pocket [chemical binding]; other site 1346614012334 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 1346614012335 AAA domain; Region: AAA_30; pfam13604 1346614012336 Family description; Region: UvrD_C_2; pfam13538 1346614012337 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 1346614012338 protease3; Provisional; Region: PRK15101 1346614012339 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1346614012340 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1346614012341 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1346614012342 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 1346614012343 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1346614012344 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 1346614012345 Protein of unknown function (DUF2509); Region: DUF2509; cl11672 1346614012346 hypothetical protein; Provisional; Region: PRK10557 1346614012347 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1346614012348 hypothetical protein; Provisional; Region: PRK10506 1346614012349 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1346614012350 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1346614012351 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1346614012352 dimerization interface [polypeptide binding]; other site 1346614012353 active site 1346614012354 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1346614012355 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 1346614012356 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1346614012357 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1346614012358 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1346614012359 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1346614012360 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1346614012361 putative active site [active] 1346614012362 Ap4A binding site [chemical binding]; other site 1346614012363 nudix motif; other site 1346614012364 putative metal binding site [ion binding]; other site 1346614012365 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 1346614012366 putative DNA-binding cleft [nucleotide binding]; other site 1346614012367 putative DNA clevage site; other site 1346614012368 molecular lever; other site 1346614012369 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1346614012370 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1346614012371 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1346614012372 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1346614012373 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1346614012374 active site 1346614012375 catalytic tetrad [active] 1346614012376 lysophospholipid transporter LplT; Provisional; Region: PRK11195 1346614012377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614012378 putative substrate translocation pore; other site 1346614012379 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 1346614012380 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1346614012381 putative acyl-acceptor binding pocket; other site 1346614012382 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 1346614012383 acyl-activating enzyme (AAE) consensus motif; other site 1346614012384 putative AMP binding site [chemical binding]; other site 1346614012385 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1346614012386 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1346614012387 molybdopterin cofactor binding site [chemical binding]; other site 1346614012388 substrate binding site [chemical binding]; other site 1346614012389 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1346614012390 molybdopterin cofactor binding site; other site 1346614012391 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 1346614012392 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1346614012393 DNA binding site [nucleotide binding] 1346614012394 domain linker motif; other site 1346614012395 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1346614012396 dimerization interface (closed form) [polypeptide binding]; other site 1346614012397 ligand binding site [chemical binding]; other site 1346614012398 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614012399 Coenzyme A binding pocket [chemical binding]; other site 1346614012400 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1346614012401 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1346614012402 DNA binding site [nucleotide binding] 1346614012403 domain linker motif; other site 1346614012404 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1346614012405 dimerization interface (closed form) [polypeptide binding]; other site 1346614012406 ligand binding site [chemical binding]; other site 1346614012407 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1346614012408 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1346614012409 sequence-specific DNA binding site [nucleotide binding]; other site 1346614012410 salt bridge; other site 1346614012411 diaminopimelate decarboxylase; Provisional; Region: PRK11165 1346614012412 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1346614012413 active site 1346614012414 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1346614012415 substrate binding site [chemical binding]; other site 1346614012416 catalytic residues [active] 1346614012417 dimer interface [polypeptide binding]; other site 1346614012418 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1346614012419 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614012420 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1346614012421 dimerization interface [polypeptide binding]; other site 1346614012422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614012423 putative substrate translocation pore; other site 1346614012424 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1346614012425 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614012426 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614012427 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1346614012428 putative effector binding pocket; other site 1346614012429 dimerization interface [polypeptide binding]; other site 1346614012430 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1346614012431 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 1346614012432 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1346614012433 catalytic residues [active] 1346614012434 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1346614012435 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1346614012436 binding surface 1346614012437 TPR motif; other site 1346614012438 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1346614012439 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1346614012440 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1346614012441 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1346614012442 active pocket/dimerization site; other site 1346614012443 active site 1346614012444 phosphorylation site [posttranslational modification] 1346614012445 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1346614012446 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 1346614012447 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1346614012448 active site 1346614012449 phosphorylation site [posttranslational modification] 1346614012450 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; pfam08013 1346614012451 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1346614012452 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1346614012453 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1346614012454 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1346614012455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614012456 putative substrate translocation pore; other site 1346614012457 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 1346614012458 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1346614012459 Walker A/P-loop; other site 1346614012460 ATP binding site [chemical binding]; other site 1346614012461 Q-loop/lid; other site 1346614012462 ABC transporter signature motif; other site 1346614012463 Walker B; other site 1346614012464 D-loop; other site 1346614012465 H-loop/switch region; other site 1346614012466 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614012467 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614012468 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1346614012469 putative effector binding pocket; other site 1346614012470 dimerization interface [polypeptide binding]; other site 1346614012471 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1346614012472 L-lactate permease; Region: Lactate_perm; cl00701 1346614012473 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1346614012474 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1346614012475 phosphate binding site [ion binding]; other site 1346614012476 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614012477 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614012478 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1346614012479 putative effector binding pocket; other site 1346614012480 dimerization interface [polypeptide binding]; other site 1346614012481 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1346614012482 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1346614012483 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 1346614012484 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 1346614012485 Walker A/P-loop; other site 1346614012486 ATP binding site [chemical binding]; other site 1346614012487 Q-loop/lid; other site 1346614012488 ABC transporter signature motif; other site 1346614012489 Walker B; other site 1346614012490 D-loop; other site 1346614012491 H-loop/switch region; other site 1346614012492 Isochorismatase family; Region: Isochorismatase; pfam00857 1346614012493 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1346614012494 catalytic triad [active] 1346614012495 dimer interface [polypeptide binding]; other site 1346614012496 conserved cis-peptide bond; other site 1346614012497 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1346614012498 dimerization interface [polypeptide binding]; other site 1346614012499 acid-resistance membrane protein; Provisional; Region: PRK10209 1346614012500 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1346614012501 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1346614012502 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1346614012503 HSP70 interaction site [polypeptide binding]; other site 1346614012504 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1346614012505 substrate binding site [polypeptide binding]; other site 1346614012506 dimer interface [polypeptide binding]; other site 1346614012507 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 1346614012508 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 1346614012509 DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077 1346614012510 Hpt domain; Region: Hpt; pfam01627 1346614012511 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 1346614012512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614012513 active site 1346614012514 phosphorylation site [posttranslational modification] 1346614012515 intermolecular recognition site; other site 1346614012516 dimerization interface [polypeptide binding]; other site 1346614012517 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1346614012518 DNA binding residues [nucleotide binding] 1346614012519 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1346614012520 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1346614012521 DNA-binding site [nucleotide binding]; DNA binding site 1346614012522 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1346614012523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614012524 putative substrate translocation pore; other site 1346614012525 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1346614012526 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1346614012527 putative ligand binding site [chemical binding]; other site 1346614012528 NAD binding site [chemical binding]; other site 1346614012529 catalytic site [active] 1346614012530 hypothetical protein; Provisional; Region: PRK15301 1346614012531 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 1346614012532 PapC N-terminal domain; Region: PapC_N; pfam13954 1346614012533 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1346614012534 PapC C-terminal domain; Region: PapC_C; pfam13953 1346614012535 putative fimbrial chaperone protein; Provisional; Region: PRK09918 1346614012536 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1346614012537 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1346614012538 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1346614012539 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1346614012540 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1346614012541 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1346614012542 DNA binding residues [nucleotide binding] 1346614012543 dimerization interface [polypeptide binding]; other site 1346614012544 PII uridylyl-transferase; Provisional; Region: PRK03059 1346614012545 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1346614012546 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1346614012547 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1346614012548 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1346614012549 dimer interface [polypeptide binding]; other site 1346614012550 putative anticodon binding site; other site 1346614012551 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1346614012552 motif 1; other site 1346614012553 active site 1346614012554 motif 2; other site 1346614012555 motif 3; other site 1346614012556 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1346614012557 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1346614012558 RF-1 domain; Region: RF-1; pfam00472 1346614012559 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1346614012560 DHH family; Region: DHH; pfam01368 1346614012561 DHHA1 domain; Region: DHHA1; pfam02272 1346614012562 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 1346614012563 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1346614012564 dimerization domain [polypeptide binding]; other site 1346614012565 dimer interface [polypeptide binding]; other site 1346614012566 catalytic residues [active] 1346614012567 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1346614012568 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1346614012569 active site 1346614012570 Int/Topo IB signature motif; other site 1346614012571 flavodoxin FldB; Provisional; Region: PRK12359 1346614012572 Inner membrane protein CreD; Region: CreD; pfam06123 1346614012573 sensory histidine kinase CreC; Provisional; Region: PRK11100 1346614012574 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1346614012575 dimerization interface [polypeptide binding]; other site 1346614012576 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1346614012577 dimer interface [polypeptide binding]; other site 1346614012578 phosphorylation site [posttranslational modification] 1346614012579 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614012580 ATP binding site [chemical binding]; other site 1346614012581 Mg2+ binding site [ion binding]; other site 1346614012582 G-X-G motif; other site 1346614012583 DNA-binding response regulator CreB; Provisional; Region: PRK11083 1346614012584 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614012585 active site 1346614012586 phosphorylation site [posttranslational modification] 1346614012587 intermolecular recognition site; other site 1346614012588 dimerization interface [polypeptide binding]; other site 1346614012589 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1346614012590 DNA binding site [nucleotide binding] 1346614012591 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 1346614012592 hypothetical protein; Provisional; Region: PRK10878 1346614012593 putative global regulator; Reviewed; Region: PRK09559 1346614012594 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1346614012595 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1346614012596 Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933 1346614012597 hemolysin; Provisional; Region: PRK15087 1346614012598 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1346614012599 HD domain; Region: HD_3; pfam13023 1346614012600 amidase; Provisional; Region: PRK07056 1346614012601 Amidase; Region: Amidase; cl11426 1346614012602 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 1346614012603 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1346614012604 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1346614012605 DNA-binding site [nucleotide binding]; DNA binding site 1346614012606 FCD domain; Region: FCD; pfam07729 1346614012607 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 1346614012608 classical (c) SDRs; Region: SDR_c; cd05233 1346614012609 NAD(P) binding site [chemical binding]; other site 1346614012610 active site 1346614012611 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1346614012612 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1346614012613 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614012614 active site 1346614012615 phosphorylation site [posttranslational modification] 1346614012616 intermolecular recognition site; other site 1346614012617 dimerization interface [polypeptide binding]; other site 1346614012618 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1346614012619 DNA binding site [nucleotide binding] 1346614012620 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1346614012621 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1346614012622 dimer interface [polypeptide binding]; other site 1346614012623 phosphorylation site [posttranslational modification] 1346614012624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614012625 ATP binding site [chemical binding]; other site 1346614012626 Mg2+ binding site [ion binding]; other site 1346614012627 G-X-G motif; other site 1346614012628 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614012629 Coenzyme A binding pocket [chemical binding]; other site 1346614012630 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1346614012631 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1346614012632 NAD(P) binding site [chemical binding]; other site 1346614012633 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1346614012634 Autotransporter beta-domain; Region: Autotransporter; smart00869 1346614012635 glycine dehydrogenase; Provisional; Region: PRK05367 1346614012636 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1346614012637 tetramer interface [polypeptide binding]; other site 1346614012638 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614012639 catalytic residue [active] 1346614012640 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1346614012641 tetramer interface [polypeptide binding]; other site 1346614012642 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614012643 catalytic residue [active] 1346614012644 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1346614012645 lipoyl attachment site [posttranslational modification]; other site 1346614012646 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1346614012647 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1346614012648 oxidoreductase; Provisional; Region: PRK08013 1346614012649 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1346614012650 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 1346614012651 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 1346614012652 proline aminopeptidase P II; Provisional; Region: PRK10879 1346614012653 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1346614012654 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1346614012655 active site 1346614012656 hypothetical protein; Reviewed; Region: PRK01736 1346614012657 Z-ring-associated protein; Provisional; Region: PRK10972 1346614012658 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1346614012659 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1346614012660 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1346614012661 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1346614012662 ligand binding site [chemical binding]; other site 1346614012663 NAD binding site [chemical binding]; other site 1346614012664 tetramer interface [polypeptide binding]; other site 1346614012665 catalytic site [active] 1346614012666 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1346614012667 L-serine binding site [chemical binding]; other site 1346614012668 ACT domain interface; other site 1346614012669 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1346614012670 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1346614012671 active site 1346614012672 dimer interface [polypeptide binding]; other site 1346614012673 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1346614012674 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614012675 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 1346614012676 putative dimerization interface [polypeptide binding]; other site 1346614012677 oxidative stress defense protein; Provisional; Region: PRK11087 1346614012678 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1346614012679 arginine exporter protein; Provisional; Region: PRK09304 1346614012680 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1346614012681 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1346614012682 Bacterial transcriptional regulator; Region: IclR; pfam01614 1346614012683 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1346614012684 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1346614012685 Walker A/P-loop; other site 1346614012686 ATP binding site [chemical binding]; other site 1346614012687 Q-loop/lid; other site 1346614012688 ABC transporter signature motif; other site 1346614012689 Walker B; other site 1346614012690 D-loop; other site 1346614012691 H-loop/switch region; other site 1346614012692 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1346614012693 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1346614012694 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1346614012695 TM-ABC transporter signature motif; other site 1346614012696 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_6; cd06315 1346614012697 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1346614012698 putative ligand binding site [chemical binding]; other site 1346614012699 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1346614012700 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 1346614012701 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1346614012702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614012703 D-galactonate transporter; Region: 2A0114; TIGR00893 1346614012704 putative substrate translocation pore; other site 1346614012705 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1346614012706 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 1346614012707 putative N- and C-terminal domain interface [polypeptide binding]; other site 1346614012708 putative active site [active] 1346614012709 MgATP binding site [chemical binding]; other site 1346614012710 catalytic site [active] 1346614012711 metal binding site [ion binding]; metal-binding site 1346614012712 putative xylulose binding site [chemical binding]; other site 1346614012713 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1346614012714 active site 1346614012715 dimer interface [polypeptide binding]; other site 1346614012716 magnesium binding site [ion binding]; other site 1346614012717 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 1346614012718 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1346614012719 AP (apurinic/apyrimidinic) site pocket; other site 1346614012720 DNA interaction; other site 1346614012721 Metal-binding active site; metal-binding site 1346614012722 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1346614012723 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1346614012724 intersubunit interface [polypeptide binding]; other site 1346614012725 active site 1346614012726 Zn2+ binding site [ion binding]; other site 1346614012727 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1346614012728 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1346614012729 active site 1346614012730 benzoate transport; Region: 2A0115; TIGR00895 1346614012731 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614012732 putative substrate translocation pore; other site 1346614012733 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614012734 mechanosensitive channel MscS; Provisional; Region: PRK10334 1346614012735 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1346614012736 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 1346614012737 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1346614012738 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 1346614012739 active site 1346614012740 intersubunit interface [polypeptide binding]; other site 1346614012741 zinc binding site [ion binding]; other site 1346614012742 Na+ binding site [ion binding]; other site 1346614012743 Phosphoglycerate kinase; Region: PGK; pfam00162 1346614012744 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1346614012745 substrate binding site [chemical binding]; other site 1346614012746 hinge regions; other site 1346614012747 ADP binding site [chemical binding]; other site 1346614012748 catalytic site [active] 1346614012749 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 1346614012750 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1346614012751 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1346614012752 transcriptional activator TtdR; Provisional; Region: PRK09801 1346614012753 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614012754 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 1346614012755 putative effector binding pocket; other site 1346614012756 putative dimerization interface [polypeptide binding]; other site 1346614012757 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1346614012758 tartrate dehydrogenase; Region: TTC; TIGR02089 1346614012759 putative transporter; Provisional; Region: PRK09950 1346614012760 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1346614012761 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1346614012762 [2Fe-2S] cluster binding site [ion binding]; other site 1346614012763 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 1346614012764 putative alpha subunit interface [polypeptide binding]; other site 1346614012765 putative active site [active] 1346614012766 putative substrate binding site [chemical binding]; other site 1346614012767 Fe binding site [ion binding]; other site 1346614012768 succinic semialdehyde dehydrogenase; Region: PLN02278 1346614012769 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1346614012770 tetramerization interface [polypeptide binding]; other site 1346614012771 NAD(P) binding site [chemical binding]; other site 1346614012772 catalytic residues [active] 1346614012773 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1346614012774 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1346614012775 FMN-binding pocket [chemical binding]; other site 1346614012776 flavin binding motif; other site 1346614012777 phosphate binding motif [ion binding]; other site 1346614012778 beta-alpha-beta structure motif; other site 1346614012779 NAD binding pocket [chemical binding]; other site 1346614012780 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1346614012781 catalytic loop [active] 1346614012782 iron binding site [ion binding]; other site 1346614012783 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1346614012784 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1346614012785 Walker A/P-loop; other site 1346614012786 ATP binding site [chemical binding]; other site 1346614012787 Q-loop/lid; other site 1346614012788 ABC transporter signature motif; other site 1346614012789 Walker B; other site 1346614012790 D-loop; other site 1346614012791 H-loop/switch region; other site 1346614012792 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1346614012793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614012794 dimer interface [polypeptide binding]; other site 1346614012795 conserved gate region; other site 1346614012796 ABC-ATPase subunit interface; other site 1346614012797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614012798 dimer interface [polypeptide binding]; other site 1346614012799 conserved gate region; other site 1346614012800 putative PBP binding loops; other site 1346614012801 ABC-ATPase subunit interface; other site 1346614012802 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1346614012803 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1346614012804 transketolase; Reviewed; Region: PRK12753 1346614012805 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1346614012806 TPP-binding site [chemical binding]; other site 1346614012807 dimer interface [polypeptide binding]; other site 1346614012808 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1346614012809 PYR/PP interface [polypeptide binding]; other site 1346614012810 dimer interface [polypeptide binding]; other site 1346614012811 TPP binding site [chemical binding]; other site 1346614012812 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1346614012813 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1346614012814 hypothetical protein; Provisional; Region: PRK07064 1346614012815 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1346614012816 PYR/PP interface [polypeptide binding]; other site 1346614012817 dimer interface [polypeptide binding]; other site 1346614012818 TPP binding site [chemical binding]; other site 1346614012819 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1346614012820 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1346614012821 TPP-binding site [chemical binding]; other site 1346614012822 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1346614012823 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 1346614012824 NAD(P) binding site [chemical binding]; other site 1346614012825 catalytic residues [active] 1346614012826 L-aspartate dehydrogenase; Provisional; Region: PRK13303 1346614012827 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1346614012828 Domain of unknown function DUF108; Region: DUF108; pfam01958 1346614012829 short chain dehydrogenase; Provisional; Region: PRK07062 1346614012830 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1346614012831 NAD(P) binding site [chemical binding]; other site 1346614012832 active site 1346614012833 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1346614012834 Cupin domain; Region: Cupin_2; pfam07883 1346614012835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614012836 D-galactonate transporter; Region: 2A0114; TIGR00893 1346614012837 putative substrate translocation pore; other site 1346614012838 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1346614012839 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1346614012840 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1346614012841 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 1346614012842 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1346614012843 putative active site [active] 1346614012844 putative metal binding site [ion binding]; other site 1346614012845 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1346614012846 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1346614012847 Bacterial transcriptional regulator; Region: IclR; pfam01614 1346614012848 short chain dehydrogenase; Provisional; Region: PRK12939 1346614012849 classical (c) SDRs; Region: SDR_c; cd05233 1346614012850 NAD(P) binding site [chemical binding]; other site 1346614012851 active site 1346614012852 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1346614012853 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1346614012854 [2Fe-2S] cluster binding site [ion binding]; other site 1346614012855 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1346614012856 hydrophobic ligand binding site; other site 1346614012857 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1346614012858 [2Fe-2S] cluster binding site [ion binding]; other site 1346614012859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614012860 D-galactonate transporter; Region: 2A0114; TIGR00893 1346614012861 putative substrate translocation pore; other site 1346614012862 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 1346614012863 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1346614012864 RNA binding surface [nucleotide binding]; other site 1346614012865 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 1346614012866 probable active site [active] 1346614012867 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1346614012868 agmatinase; Region: agmatinase; TIGR01230 1346614012869 oligomer interface [polypeptide binding]; other site 1346614012870 putative active site [active] 1346614012871 Mn binding site [ion binding]; other site 1346614012872 arginine decarboxylase; Provisional; Region: PRK05354 1346614012873 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1346614012874 dimer interface [polypeptide binding]; other site 1346614012875 active site 1346614012876 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1346614012877 catalytic residues [active] 1346614012878 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1346614012879 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1346614012880 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1346614012881 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1346614012882 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1346614012883 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1346614012884 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1346614012885 ABC-ATPase subunit interface; other site 1346614012886 dimer interface [polypeptide binding]; other site 1346614012887 putative PBP binding regions; other site 1346614012888 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1346614012889 ABC-ATPase subunit interface; other site 1346614012890 dimer interface [polypeptide binding]; other site 1346614012891 putative PBP binding regions; other site 1346614012892 iron-hydroxamate transporter substrate-binding subunit; Provisional; Region: PRK10576 1346614012893 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1346614012894 intersubunit interface [polypeptide binding]; other site 1346614012895 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 1346614012896 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1346614012897 Walker A/P-loop; other site 1346614012898 ATP binding site [chemical binding]; other site 1346614012899 Q-loop/lid; other site 1346614012900 ABC transporter signature motif; other site 1346614012901 Walker B; other site 1346614012902 D-loop; other site 1346614012903 H-loop/switch region; other site 1346614012904 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1346614012905 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1346614012906 N-terminal plug; other site 1346614012907 ligand-binding site [chemical binding]; other site 1346614012908 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 1346614012909 Transglycosylase; Region: Transgly; pfam00912 1346614012910 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1346614012911 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 1346614012912 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1346614012913 ATP binding site [chemical binding]; other site 1346614012914 putative Mg++ binding site [ion binding]; other site 1346614012915 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1346614012916 nucleotide binding region [chemical binding]; other site 1346614012917 ATP-binding site [chemical binding]; other site 1346614012918 Helicase associated domain (HA2); Region: HA2; pfam04408 1346614012919 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1346614012920 2'-5' RNA ligase; Provisional; Region: PRK15124 1346614012921 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1346614012922 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1346614012923 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 1346614012924 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1346614012925 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 1346614012926 active site 1346614012927 nucleotide binding site [chemical binding]; other site 1346614012928 HIGH motif; other site 1346614012929 KMSKS motif; other site 1346614012930 poly(A) polymerase; Region: pcnB; TIGR01942 1346614012931 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1346614012932 active site 1346614012933 NTP binding site [chemical binding]; other site 1346614012934 metal binding triad [ion binding]; metal-binding site 1346614012935 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1346614012936 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1346614012937 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1346614012938 catalytic center binding site [active] 1346614012939 ATP binding site [chemical binding]; other site 1346614012940 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 1346614012941 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614012942 active site 1346614012943 phosphorylation site [posttranslational modification] 1346614012944 intermolecular recognition site; other site 1346614012945 dimerization interface [polypeptide binding]; other site 1346614012946 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1346614012947 DNA binding site [nucleotide binding] 1346614012948 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1346614012949 oligomerization interface [polypeptide binding]; other site 1346614012950 active site 1346614012951 metal binding site [ion binding]; metal-binding site 1346614012952 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1346614012953 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1346614012954 active site 1346614012955 ATP-binding site [chemical binding]; other site 1346614012956 pantoate-binding site; other site 1346614012957 HXXH motif; other site 1346614012958 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1346614012959 tetramerization interface [polypeptide binding]; other site 1346614012960 active site 1346614012961 Bacterial SH3 domain; Region: SH3_3; cl17532 1346614012962 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 1346614012963 putative active site [active] 1346614012964 putative metal binding site [ion binding]; other site 1346614012965 inner membrane transport permease; Provisional; Region: PRK15066 1346614012966 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1346614012967 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1346614012968 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1346614012969 Walker A/P-loop; other site 1346614012970 ATP binding site [chemical binding]; other site 1346614012971 Q-loop/lid; other site 1346614012972 ABC transporter signature motif; other site 1346614012973 Walker B; other site 1346614012974 D-loop; other site 1346614012975 H-loop/switch region; other site 1346614012976 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1346614012977 active site clefts [active] 1346614012978 zinc binding site [ion binding]; other site 1346614012979 dimer interface [polypeptide binding]; other site 1346614012980 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1346614012981 active site 1346614012982 multicopper oxidase; Provisional; Region: PRK10965 1346614012983 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1346614012984 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1346614012985 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 1346614012986 spermidine synthase; Provisional; Region: PRK00811 1346614012987 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614012988 S-adenosylmethionine binding site [chemical binding]; other site 1346614012989 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 1346614012990 hypothetical protein; Provisional; Region: PRK05248 1346614012991 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1346614012992 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1346614012993 substrate binding site [chemical binding]; other site 1346614012994 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1346614012995 substrate binding site [chemical binding]; other site 1346614012996 ligand binding site [chemical binding]; other site 1346614012997 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1346614012998 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1346614012999 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1346614013000 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1346614013001 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 1346614013002 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1346614013003 E3 interaction surface; other site 1346614013004 lipoyl attachment site [posttranslational modification]; other site 1346614013005 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1346614013006 E3 interaction surface; other site 1346614013007 lipoyl attachment site [posttranslational modification]; other site 1346614013008 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1346614013009 E3 interaction surface; other site 1346614013010 lipoyl attachment site [posttranslational modification]; other site 1346614013011 e3 binding domain; Region: E3_binding; pfam02817 1346614013012 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1346614013013 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1346614013014 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1346614013015 dimer interface [polypeptide binding]; other site 1346614013016 TPP-binding site [chemical binding]; other site 1346614013017 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 1346614013018 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1346614013019 DNA-binding site [nucleotide binding]; DNA binding site 1346614013020 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1346614013021 aromatic amino acid transporter; Provisional; Region: PRK10238 1346614013022 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1346614013023 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1346614013024 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1346614013025 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1346614013026 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1346614013027 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1346614013028 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1346614013029 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1346614013030 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1346614013031 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1346614013032 Ligand binding site; other site 1346614013033 metal-binding site 1346614013034 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1346614013035 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1346614013036 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1346614013037 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1346614013038 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614013039 fumarate hydratase; Provisional; Region: PRK15389 1346614013040 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1346614013041 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1346614013042 hypothetical protein; Provisional; Region: PRK04860 1346614013043 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1346614013044 DNA-specific endonuclease I; Provisional; Region: PRK15137 1346614013045 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 1346614013046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1346614013047 RNA methyltransferase, RsmE family; Region: TIGR00046 1346614013048 glutathione synthetase; Provisional; Region: PRK05246 1346614013049 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1346614013050 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1346614013051 hypothetical protein; Validated; Region: PRK00228 1346614013052 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1346614013053 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1346614013054 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1346614013055 Walker A motif; other site 1346614013056 ATP binding site [chemical binding]; other site 1346614013057 Walker B motif; other site 1346614013058 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1346614013059 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1346614013060 catalytic residue [active] 1346614013061 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1346614013062 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1346614013063 NAD(P) binding site [chemical binding]; other site 1346614013064 YGGT family; Region: YGGT; pfam02325 1346614013065 YGGT family; Region: YGGT; pfam02325 1346614013066 hypothetical protein; Validated; Region: PRK05090 1346614013067 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1346614013068 active site 1346614013069 dimerization interface [polypeptide binding]; other site 1346614013070 HemN family oxidoreductase; Provisional; Region: PRK05660 1346614013071 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1346614013072 FeS/SAM binding site; other site 1346614013073 HemN C-terminal domain; Region: HemN_C; pfam06969 1346614013074 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 1346614013075 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 1346614013076 hypothetical protein; Provisional; Region: PRK10626 1346614013077 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 1346614013078 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1346614013079 glutaminase; Provisional; Region: PRK00971 1346614013080 hypothetical protein; Provisional; Region: PRK11702 1346614013081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614013082 S-adenosylmethionine binding site [chemical binding]; other site 1346614013083 adenine DNA glycosylase; Provisional; Region: PRK10880 1346614013084 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1346614013085 minor groove reading motif; other site 1346614013086 helix-hairpin-helix signature motif; other site 1346614013087 substrate binding pocket [chemical binding]; other site 1346614013088 active site 1346614013089 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1346614013090 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1346614013091 DNA binding and oxoG recognition site [nucleotide binding] 1346614013092 oxidative damage protection protein; Provisional; Region: PRK05408 1346614013093 murein transglycosylase C; Provisional; Region: mltC; PRK11671 1346614013094 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 1346614013095 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1346614013096 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1346614013097 catalytic residue [active] 1346614013098 ornithine decarboxylase; Provisional; Region: PRK13578 1346614013099 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1346614013100 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1346614013101 homodimer interface [polypeptide binding]; other site 1346614013102 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614013103 catalytic residue [active] 1346614013104 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1346614013105 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1346614013106 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614013107 Coenzyme A binding pocket [chemical binding]; other site 1346614013108 PAS fold; Region: PAS_4; pfam08448 1346614013109 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1346614013110 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1346614013111 DNA binding residues [nucleotide binding] 1346614013112 dimerization interface [polypeptide binding]; other site 1346614013113 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1346614013114 Na binding site [ion binding]; other site 1346614013115 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1346614013116 non-specific DNA binding site [nucleotide binding]; other site 1346614013117 salt bridge; other site 1346614013118 sequence-specific DNA binding site [nucleotide binding]; other site 1346614013119 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 1346614013120 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1346614013121 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 1346614013122 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1346614013123 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 1346614013124 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1346614013125 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1346614013126 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1346614013127 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 1346614013128 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 1346614013129 putative ligand binding residues [chemical binding]; other site 1346614013130 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 1346614013131 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1346614013132 N-terminal plug; other site 1346614013133 ligand-binding site [chemical binding]; other site 1346614013134 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 1346614013135 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614013136 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1346614013137 dimerization interface [polypeptide binding]; other site 1346614013138 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1346614013139 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 1346614013140 putative metal binding site [ion binding]; other site 1346614013141 dimer interface [polypeptide binding]; other site 1346614013142 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 1346614013143 amidohydrolase; Region: amidohydrolases; TIGR01891 1346614013144 putative metal binding site [ion binding]; other site 1346614013145 putative aminobenzoyl-glutamate transporter; Provisional; Region: abgT; PRK11339 1346614013146 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 1346614013147 Protein of unknown function, DUF596; Region: DUF596; cl10492 1346614013148 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1346614013149 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1346614013150 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1346614013151 adhesin HecA family 20-residue repeat (two copies); Region: fil_hemag_20aa; TIGR01731 1346614013152 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1346614013153 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1346614013154 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1346614013155 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1346614013156 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1346614013157 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1346614013158 RTX toxin acyltransferase family; Region: HlyC; pfam02794 1346614013159 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1346614013160 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1346614013161 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1346614013162 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1346614013163 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1346614013164 putative substrate binding site [chemical binding]; other site 1346614013165 putative ATP binding site [chemical binding]; other site 1346614013166 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 1346614013167 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1346614013168 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1346614013169 active site turn [active] 1346614013170 phosphorylation site [posttranslational modification] 1346614013171 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1346614013172 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1346614013173 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1346614013174 substrate binding [chemical binding]; other site 1346614013175 active site 1346614013176 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1346614013177 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 1346614013178 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1346614013179 DNA binding site [nucleotide binding] 1346614013180 domain linker motif; other site 1346614013181 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1346614013182 dimerization interface [polypeptide binding]; other site 1346614013183 ligand binding site [chemical binding]; other site 1346614013184 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 1346614013185 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1346614013186 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1346614013187 shikimate binding site; other site 1346614013188 NAD(P) binding site [chemical binding]; other site 1346614013189 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1346614013190 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 1346614013191 biopolymer transport protein ExbD; Provisional; Region: PRK11267 1346614013192 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1346614013193 biopolymer transport protein ExbB; Provisional; Region: PRK10414 1346614013194 cystathionine beta-lyase; Provisional; Region: PRK08114 1346614013195 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1346614013196 homodimer interface [polypeptide binding]; other site 1346614013197 substrate-cofactor binding pocket; other site 1346614013198 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614013199 catalytic residue [active] 1346614013200 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1346614013201 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1346614013202 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614013203 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614013204 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 1346614013205 putative effector binding pocket; other site 1346614013206 putative dimerization interface [polypeptide binding]; other site 1346614013207 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 1346614013208 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1346614013209 putative NAD(P) binding site [chemical binding]; other site 1346614013210 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1346614013211 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1346614013212 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614013213 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614013214 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1346614013215 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1346614013216 dimer interface [polypeptide binding]; other site 1346614013217 active site 1346614013218 metal binding site [ion binding]; metal-binding site 1346614013219 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1346614013220 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1346614013221 active site 1346614013222 catalytic tetrad [active] 1346614013223 hypothetical protein; Provisional; Region: PRK08204 1346614013224 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1346614013225 active site 1346614013226 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1346614013227 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1346614013228 beta-galactosidase; Region: BGL; TIGR03356 1346614013229 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1346614013230 methionine cluster; other site 1346614013231 active site 1346614013232 phosphorylation site [posttranslational modification] 1346614013233 metal binding site [ion binding]; metal-binding site 1346614013234 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1346614013235 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1346614013236 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1346614013237 active site 1346614013238 P-loop; other site 1346614013239 phosphorylation site [posttranslational modification] 1346614013240 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 1346614013241 active site 1346614013242 catalytic residues [active] 1346614013243 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 1346614013244 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1346614013245 putative NAD(P) binding site [chemical binding]; other site 1346614013246 catalytic Zn binding site [ion binding]; other site 1346614013247 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1346614013248 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1346614013249 TM-ABC transporter signature motif; other site 1346614013250 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1346614013251 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1346614013252 Walker A/P-loop; other site 1346614013253 ATP binding site [chemical binding]; other site 1346614013254 Q-loop/lid; other site 1346614013255 ABC transporter signature motif; other site 1346614013256 Walker B; other site 1346614013257 D-loop; other site 1346614013258 H-loop/switch region; other site 1346614013259 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1346614013260 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1346614013261 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1346614013262 ligand binding site [chemical binding]; other site 1346614013263 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1346614013264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614013265 putative substrate translocation pore; other site 1346614013266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614013267 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 1346614013268 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1346614013269 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1346614013270 TPR motif; other site 1346614013271 binding surface 1346614013272 TPR repeat; Region: TPR_11; pfam13414 1346614013273 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1346614013274 binding surface 1346614013275 TPR motif; other site 1346614013276 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 1346614013277 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1346614013278 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1346614013279 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 1346614013280 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1346614013281 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1346614013282 catalytic residue [active] 1346614013283 hypothetical protein; Provisional; Region: PRK01254 1346614013284 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1346614013285 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 1346614013286 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1346614013287 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1346614013288 substrate binding site [chemical binding]; other site 1346614013289 ATP binding site [chemical binding]; other site 1346614013290 nucleoside transporter; Region: 2A0110; TIGR00889 1346614013291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614013292 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614013293 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1346614013294 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1346614013295 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614013296 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 1346614013297 putative dimerization interface [polypeptide binding]; other site 1346614013298 putative substrate binding pocket [chemical binding]; other site 1346614013299 FtsI repressor; Provisional; Region: PRK10883 1346614013300 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1346614013301 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1346614013302 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 1346614013303 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1346614013304 putative acyl-acceptor binding pocket; other site 1346614013305 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1346614013306 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1346614013307 CAP-like domain; other site 1346614013308 active site 1346614013309 primary dimer interface [polypeptide binding]; other site 1346614013310 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1346614013311 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1346614013312 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614013313 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614013314 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1346614013315 dimerization interface [polypeptide binding]; other site 1346614013316 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1346614013317 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614013318 ATP binding site [chemical binding]; other site 1346614013319 Mg2+ binding site [ion binding]; other site 1346614013320 G-X-G motif; other site 1346614013321 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1346614013322 anchoring element; other site 1346614013323 dimer interface [polypeptide binding]; other site 1346614013324 ATP binding site [chemical binding]; other site 1346614013325 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1346614013326 active site 1346614013327 metal binding site [ion binding]; metal-binding site 1346614013328 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1346614013329 esterase YqiA; Provisional; Region: PRK11071 1346614013330 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1346614013331 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1346614013332 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1346614013333 active site 1346614013334 metal binding site [ion binding]; metal-binding site 1346614013335 hexamer interface [polypeptide binding]; other site 1346614013336 putative dehydrogenase; Provisional; Region: PRK11039 1346614013337 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1346614013338 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1346614013339 dimer interface [polypeptide binding]; other site 1346614013340 ADP-ribose binding site [chemical binding]; other site 1346614013341 active site 1346614013342 nudix motif; other site 1346614013343 metal binding site [ion binding]; metal-binding site 1346614013344 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 1346614013345 mannonate dehydratase; Region: uxuA; TIGR00695 1346614013346 D-mannonate dehydratase [Carbohydrate transport and metabolism]; Region: UxuA; COG1312 1346614013347 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 1346614013348 PAS domain; Region: PAS; smart00091 1346614013349 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1346614013350 Walker A motif; other site 1346614013351 ATP binding site [chemical binding]; other site 1346614013352 Walker B motif; other site 1346614013353 arginine finger; other site 1346614013354 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1346614013355 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 1346614013356 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 1346614013357 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1346614013358 dimerization domain swap beta strand [polypeptide binding]; other site 1346614013359 regulatory protein interface [polypeptide binding]; other site 1346614013360 active site 1346614013361 regulatory phosphorylation site [posttranslational modification]; other site 1346614013362 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1346614013363 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1346614013364 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 1346614013365 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 1346614013366 Dak1 domain; Region: Dak1; pfam02733 1346614013367 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1346614013368 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1346614013369 dimer interface [polypeptide binding]; other site 1346614013370 active site 1346614013371 metal binding site [ion binding]; metal-binding site 1346614013372 hypothetical protein; Provisional; Region: PRK11653 1346614013373 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1346614013374 glucose-6-phosphate isomerase; Provisional; Region: PRK04190 1346614013375 Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560 1346614013376 Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560 1346614013377 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1346614013378 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 1346614013379 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 1346614013380 active site 1346614013381 phosphorylation site [posttranslational modification] 1346614013382 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1346614013383 active pocket/dimerization site; other site 1346614013384 active site 1346614013385 phosphorylation site [posttranslational modification] 1346614013386 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1346614013387 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1346614013388 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1346614013389 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1346614013390 DNA binding site [nucleotide binding] 1346614013391 domain linker motif; other site 1346614013392 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 1346614013393 putative ligand binding site [chemical binding]; other site 1346614013394 putative dimerization interface [polypeptide binding]; other site 1346614013395 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1346614013396 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1346614013397 putative active site [active] 1346614013398 metal binding site [ion binding]; metal-binding site 1346614013399 zinc transporter ZupT; Provisional; Region: PRK04201 1346614013400 ZIP Zinc transporter; Region: Zip; pfam02535 1346614013401 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 1346614013402 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1346614013403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 1346614013404 putative transporter; Provisional; Region: PRK11021 1346614013405 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 1346614013406 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1346614013407 putative ribose interaction site [chemical binding]; other site 1346614013408 putative ADP binding site [chemical binding]; other site 1346614013409 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1346614013410 active site 1346614013411 nucleotide binding site [chemical binding]; other site 1346614013412 HIGH motif; other site 1346614013413 KMSKS motif; other site 1346614013414 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1346614013415 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1346614013416 metal binding triad; other site 1346614013417 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1346614013418 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1346614013419 metal binding triad; other site 1346614013420 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1346614013421 Uncharacterized conserved protein [Function unknown]; Region: COG3025 1346614013422 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1346614013423 putative active site [active] 1346614013424 putative metal binding residues [ion binding]; other site 1346614013425 signature motif; other site 1346614013426 putative triphosphate binding site [ion binding]; other site 1346614013427 CHAD domain; Region: CHAD; pfam05235 1346614013428 SH3 domain-containing protein; Provisional; Region: PRK10884 1346614013429 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1346614013430 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1346614013431 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1346614013432 active site 1346614013433 NTP binding site [chemical binding]; other site 1346614013434 metal binding triad [ion binding]; metal-binding site 1346614013435 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1346614013436 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1346614013437 Zn2+ binding site [ion binding]; other site 1346614013438 Mg2+ binding site [ion binding]; other site 1346614013439 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1346614013440 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1346614013441 homooctamer interface [polypeptide binding]; other site 1346614013442 active site 1346614013443 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1346614013444 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1346614013445 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1346614013446 N-terminal plug; other site 1346614013447 ligand-binding site [chemical binding]; other site 1346614013448 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1346614013449 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1346614013450 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1346614013451 Walker A/P-loop; other site 1346614013452 ATP binding site [chemical binding]; other site 1346614013453 Q-loop/lid; other site 1346614013454 ABC transporter signature motif; other site 1346614013455 Walker B; other site 1346614013456 D-loop; other site 1346614013457 H-loop/switch region; other site 1346614013458 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1346614013459 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1346614013460 Walker A/P-loop; other site 1346614013461 ATP binding site [chemical binding]; other site 1346614013462 Q-loop/lid; other site 1346614013463 ABC transporter signature motif; other site 1346614013464 Walker B; other site 1346614013465 D-loop; other site 1346614013466 H-loop/switch region; other site 1346614013467 UGMP family protein; Validated; Region: PRK09604 1346614013468 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1346614013469 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1346614013470 DNA primase; Validated; Region: dnaG; PRK05667 1346614013471 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1346614013472 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1346614013473 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1346614013474 active site 1346614013475 metal binding site [ion binding]; metal-binding site 1346614013476 interdomain interaction site; other site 1346614013477 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1346614013478 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1346614013479 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1346614013480 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1346614013481 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1346614013482 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1346614013483 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1346614013484 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1346614013485 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1346614013486 DNA binding residues [nucleotide binding] 1346614013487 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1346614013488 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1346614013489 active site 1346614013490 SUMO-1 interface [polypeptide binding]; other site 1346614013491 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 1346614013492 HPP family; Region: HPP; pfam04982 1346614013493 glutathione S-transferase; Provisional; Region: PRK15113 1346614013494 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1346614013495 C-terminal domain interface [polypeptide binding]; other site 1346614013496 GSH binding site (G-site) [chemical binding]; other site 1346614013497 dimer interface [polypeptide binding]; other site 1346614013498 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 1346614013499 N-terminal domain interface [polypeptide binding]; other site 1346614013500 putative dimer interface [polypeptide binding]; other site 1346614013501 putative substrate binding pocket (H-site) [chemical binding]; other site 1346614013502 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1346614013503 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1346614013504 succinic semialdehyde dehydrogenase; Region: PLN02278 1346614013505 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1346614013506 tetramerization interface [polypeptide binding]; other site 1346614013507 NAD(P) binding site [chemical binding]; other site 1346614013508 catalytic residues [active] 1346614013509 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 1346614013510 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1346614013511 inhibitor-cofactor binding pocket; inhibition site 1346614013512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614013513 catalytic residue [active] 1346614013514 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1346614013515 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1346614013516 DNA-binding site [nucleotide binding]; DNA binding site 1346614013517 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1346614013518 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614013519 homodimer interface [polypeptide binding]; other site 1346614013520 catalytic residue [active] 1346614013521 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1346614013522 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1346614013523 ABC transporter; Region: ABC_tran_2; pfam12848 1346614013524 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1346614013525 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1346614013526 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1346614013527 active site 1346614013528 FMN binding site [chemical binding]; other site 1346614013529 2,4-decadienoyl-CoA binding site; other site 1346614013530 catalytic residue [active] 1346614013531 4Fe-4S cluster binding site [ion binding]; other site 1346614013532 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1346614013533 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1346614013534 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 1346614013535 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614013536 S-adenosylmethionine binding site [chemical binding]; other site 1346614013537 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1346614013538 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1346614013539 sequence-specific DNA binding site [nucleotide binding]; other site 1346614013540 salt bridge; other site 1346614013541 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1346614013542 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1346614013543 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1346614013544 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1346614013545 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1346614013546 catalytic triad [active] 1346614013547 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1346614013548 serine/threonine transporter SstT; Provisional; Region: PRK13628 1346614013549 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1346614013550 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1346614013551 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1346614013552 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1346614013553 Glucuronate isomerase; Region: UxaC; pfam02614 1346614013554 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1346614013555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614013556 D-galactonate transporter; Region: 2A0114; TIGR00893 1346614013557 putative substrate translocation pore; other site 1346614013558 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 1346614013559 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1346614013560 DNA-binding site [nucleotide binding]; DNA binding site 1346614013561 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1346614013562 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1346614013563 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1346614013564 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 1346614013565 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 1346614013566 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 1346614013567 Predicted membrane protein [Function unknown]; Region: COG5393 1346614013568 YqjK-like protein; Region: YqjK; pfam13997 1346614013569 Predicted membrane protein [Function unknown]; Region: COG2259 1346614013570 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1346614013571 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1346614013572 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1346614013573 putative dimer interface [polypeptide binding]; other site 1346614013574 N-terminal domain interface [polypeptide binding]; other site 1346614013575 putative substrate binding pocket (H-site) [chemical binding]; other site 1346614013576 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1346614013577 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614013578 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1346614013579 dimerization interface [polypeptide binding]; other site 1346614013580 Pirin-related protein [General function prediction only]; Region: COG1741 1346614013581 Pirin; Region: Pirin; pfam02678 1346614013582 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 1346614013583 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1346614013584 putative SAM binding site [chemical binding]; other site 1346614013585 putative homodimer interface [polypeptide binding]; other site 1346614013586 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 1346614013587 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1346614013588 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1346614013589 putative ligand binding site [chemical binding]; other site 1346614013590 hypothetical protein; Reviewed; Region: PRK12497 1346614013591 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1346614013592 dimer interface [polypeptide binding]; other site 1346614013593 active site 1346614013594 outer membrane lipoprotein; Provisional; Region: PRK11023 1346614013595 BON domain; Region: BON; pfam04972 1346614013596 BON domain; Region: BON; pfam04972 1346614013597 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 1346614013598 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 1346614013599 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1346614013600 Transglycosylase; Region: Transgly; cl17702 1346614013601 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 1346614013602 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 1346614013603 conserved cys residue [active] 1346614013604 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 1346614013605 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1346614013606 putative active site [active] 1346614013607 heme pocket [chemical binding]; other site 1346614013608 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1346614013609 dimer interface [polypeptide binding]; other site 1346614013610 phosphorylation site [posttranslational modification] 1346614013611 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614013612 ATP binding site [chemical binding]; other site 1346614013613 Mg2+ binding site [ion binding]; other site 1346614013614 G-X-G motif; other site 1346614013615 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614013616 active site 1346614013617 phosphorylation site [posttranslational modification] 1346614013618 intermolecular recognition site; other site 1346614013619 dimerization interface [polypeptide binding]; other site 1346614013620 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1346614013621 putative binding surface; other site 1346614013622 active site 1346614013623 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1346614013624 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1346614013625 FeS/SAM binding site; other site 1346614013626 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1346614013627 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1346614013628 active site 1346614013629 dimer interface [polypeptide binding]; other site 1346614013630 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1346614013631 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1346614013632 active site 1346614013633 FMN binding site [chemical binding]; other site 1346614013634 substrate binding site [chemical binding]; other site 1346614013635 3Fe-4S cluster binding site [ion binding]; other site 1346614013636 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1346614013637 domain interface; other site 1346614013638 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 1346614013639 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1346614013640 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1346614013641 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1346614013642 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 1346614013643 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1346614013644 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 1346614013645 C-terminal domain interface [polypeptide binding]; other site 1346614013646 putative GSH binding site (G-site) [chemical binding]; other site 1346614013647 dimer interface [polypeptide binding]; other site 1346614013648 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1346614013649 dimer interface [polypeptide binding]; other site 1346614013650 N-terminal domain interface [polypeptide binding]; other site 1346614013651 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1346614013652 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1346614013653 23S rRNA interface [nucleotide binding]; other site 1346614013654 L3 interface [polypeptide binding]; other site 1346614013655 Predicted ATPase [General function prediction only]; Region: COG1485 1346614013656 hypothetical protein; Provisional; Region: PRK11677 1346614013657 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 1346614013658 serine endoprotease; Provisional; Region: PRK10139 1346614013659 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1346614013660 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1346614013661 protein binding site [polypeptide binding]; other site 1346614013662 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1346614013663 serine endoprotease; Provisional; Region: PRK10898 1346614013664 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1346614013665 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1346614013666 protein binding site [polypeptide binding]; other site 1346614013667 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1346614013668 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1346614013669 hinge; other site 1346614013670 active site 1346614013671 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 1346614013672 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1346614013673 anti sigma factor interaction site; other site 1346614013674 regulatory phosphorylation site [posttranslational modification]; other site 1346614013675 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 1346614013676 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1346614013677 mce related protein; Region: MCE; pfam02470 1346614013678 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1346614013679 conserved hypothetical integral membrane protein; Region: TIGR00056 1346614013680 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 1346614013681 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1346614013682 Walker A/P-loop; other site 1346614013683 ATP binding site [chemical binding]; other site 1346614013684 Q-loop/lid; other site 1346614013685 ABC transporter signature motif; other site 1346614013686 Walker B; other site 1346614013687 D-loop; other site 1346614013688 H-loop/switch region; other site 1346614013689 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 1346614013690 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1346614013691 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1346614013692 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1346614013693 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1346614013694 putative active site [active] 1346614013695 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1346614013696 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 1346614013697 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1346614013698 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 1346614013699 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1346614013700 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 1346614013701 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1346614013702 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 1346614013703 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1346614013704 Walker A/P-loop; other site 1346614013705 ATP binding site [chemical binding]; other site 1346614013706 Q-loop/lid; other site 1346614013707 ABC transporter signature motif; other site 1346614013708 Walker B; other site 1346614013709 D-loop; other site 1346614013710 H-loop/switch region; other site 1346614013711 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1346614013712 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1346614013713 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1346614013714 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1346614013715 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1346614013716 30S subunit binding site; other site 1346614013717 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1346614013718 active site 1346614013719 phosphorylation site [posttranslational modification] 1346614013720 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 1346614013721 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1346614013722 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1346614013723 dimerization domain swap beta strand [polypeptide binding]; other site 1346614013724 regulatory protein interface [polypeptide binding]; other site 1346614013725 active site 1346614013726 regulatory phosphorylation site [posttranslational modification]; other site 1346614013727 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 1346614013728 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1346614013729 salt bridge; other site 1346614013730 non-specific DNA binding site [nucleotide binding]; other site 1346614013731 sequence-specific DNA binding site [nucleotide binding]; other site 1346614013732 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1346614013733 HTH domain; Region: HTH_11; pfam08279 1346614013734 Mga helix-turn-helix domain; Region: Mga; pfam05043 1346614013735 PRD domain; Region: PRD; pfam00874 1346614013736 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1346614013737 active site 1346614013738 P-loop; other site 1346614013739 phosphorylation site [posttranslational modification] 1346614013740 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1346614013741 active site 1346614013742 phosphorylation site [posttranslational modification] 1346614013743 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1346614013744 Protein of unknown function (DUF1341); Region: DUF1341; pfam07071 1346614013745 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 1346614013746 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1346614013747 catalytic residue [active] 1346614013748 dihydroorotase; Provisional; Region: PRK09237 1346614013749 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 1346614013750 active site 1346614013751 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 1346614013752 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 1346614013753 Domain of unknown function (DUF4312); Region: DUF4312; pfam14189 1346614013754 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272 1346614013755 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 1346614013756 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1346614013757 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1346614013758 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1346614013759 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1346614013760 Helix-turn-helix domain; Region: HTH_18; pfam12833 1346614013761 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614013762 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1346614013763 Cytochrome b562; Region: Cytochrom_B562; cl01546 1346614013764 peptidase PmbA; Provisional; Region: PRK11040 1346614013765 hypothetical protein; Provisional; Region: PRK05255 1346614013766 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1346614013767 RNAase interaction site [polypeptide binding]; other site 1346614013768 Barnase, a member of the family of homologous microbial ribonucleases, catalyses the cleavage of single-stranded RNA via a two-step mechanism thought to be similar to that of pancreatic ribonuclease. The mechanism involves a transesterification to give a...; Region: barnase; cd00933 1346614013769 active site 1346614013770 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 1346614013771 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1346614013772 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 1346614013773 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1346614013774 HlyD family secretion protein; Region: HlyD_3; pfam13437 1346614013775 efflux system membrane protein; Provisional; Region: PRK11594 1346614013776 transcriptional regulator; Provisional; Region: PRK10632 1346614013777 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614013778 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1346614013779 putative effector binding pocket; other site 1346614013780 dimerization interface [polypeptide binding]; other site 1346614013781 Double zinc ribbon; Region: DZR; pfam12773 1346614013782 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1346614013783 active site 1346614013784 tetramer interface [polypeptide binding]; other site 1346614013785 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 1346614013786 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1346614013787 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1346614013788 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1346614013789 protease TldD; Provisional; Region: tldD; PRK10735 1346614013790 nitrilase; Region: PLN02798 1346614013791 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 1346614013792 putative active site [active] 1346614013793 catalytic triad [active] 1346614013794 dimer interface [polypeptide binding]; other site 1346614013795 hypothetical protein; Provisional; Region: PRK10899 1346614013796 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1346614013797 ribonuclease G; Provisional; Region: PRK11712 1346614013798 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1346614013799 homodimer interface [polypeptide binding]; other site 1346614013800 oligonucleotide binding site [chemical binding]; other site 1346614013801 Maf-like protein; Region: Maf; pfam02545 1346614013802 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1346614013803 active site 1346614013804 dimer interface [polypeptide binding]; other site 1346614013805 rod shape-determining protein MreD; Provisional; Region: PRK11060 1346614013806 rod shape-determining protein MreC; Region: mreC; TIGR00219 1346614013807 rod shape-determining protein MreC; Region: MreC; pfam04085 1346614013808 rod shape-determining protein MreB; Provisional; Region: PRK13927 1346614013809 MreB and similar proteins; Region: MreB_like; cd10225 1346614013810 nucleotide binding site [chemical binding]; other site 1346614013811 Mg binding site [ion binding]; other site 1346614013812 putative protofilament interaction site [polypeptide binding]; other site 1346614013813 RodZ interaction site [polypeptide binding]; other site 1346614013814 regulatory protein CsrD; Provisional; Region: PRK11059 1346614013815 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1346614013816 metal binding site [ion binding]; metal-binding site 1346614013817 active site 1346614013818 I-site; other site 1346614013819 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1346614013820 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1346614013821 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1346614013822 NADP binding site [chemical binding]; other site 1346614013823 dimer interface [polypeptide binding]; other site 1346614013824 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1346614013825 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 1346614013826 Moco binding site; other site 1346614013827 metal coordination site [ion binding]; other site 1346614013828 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1346614013829 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1346614013830 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1346614013831 active site 1346614013832 trimer interface [polypeptide binding]; other site 1346614013833 dimer interface [polypeptide binding]; other site 1346614013834 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1346614013835 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1346614013836 carboxyltransferase (CT) interaction site; other site 1346614013837 biotinylation site [posttranslational modification]; other site 1346614013838 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1346614013839 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1346614013840 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1346614013841 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1346614013842 hypothetical protein; Provisional; Region: PRK10633 1346614013843 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 1346614013844 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1346614013845 Na binding site [ion binding]; other site 1346614013846 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1346614013847 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1346614013848 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 1346614013849 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1346614013850 FMN binding site [chemical binding]; other site 1346614013851 active site 1346614013852 catalytic residues [active] 1346614013853 substrate binding site [chemical binding]; other site 1346614013854 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 1346614013855 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 1346614013856 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 1346614013857 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1346614013858 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1346614013859 putative acyl-acceptor binding pocket; other site 1346614013860 hypothetical protein; Validated; Region: PRK06186 1346614013861 conserved cys residue [active] 1346614013862 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1346614013863 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1346614013864 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614013865 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614013866 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1346614013867 putative dimerization interface [polypeptide binding]; other site 1346614013868 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1346614013869 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1346614013870 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1346614013871 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1346614013872 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1346614013873 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1346614013874 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1346614013875 putative C-terminal domain interface [polypeptide binding]; other site 1346614013876 putative GSH binding site (G-site) [chemical binding]; other site 1346614013877 putative dimer interface [polypeptide binding]; other site 1346614013878 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 1346614013879 putative N-terminal domain interface [polypeptide binding]; other site 1346614013880 putative dimer interface [polypeptide binding]; other site 1346614013881 putative substrate binding pocket (H-site) [chemical binding]; other site 1346614013882 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1346614013883 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614013884 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614013885 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1346614013886 putative effector binding pocket; other site 1346614013887 dimerization interface [polypeptide binding]; other site 1346614013888 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1346614013889 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1346614013890 NAD(P) binding site [chemical binding]; other site 1346614013891 active site 1346614013892 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1346614013893 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1346614013894 dimer interface [polypeptide binding]; other site 1346614013895 ssDNA binding site [nucleotide binding]; other site 1346614013896 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1346614013897 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1346614013898 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1346614013899 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1346614013900 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1346614013901 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1346614013902 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1346614013903 putative NAD(P) binding site [chemical binding]; other site 1346614013904 putative substrate binding site [chemical binding]; other site 1346614013905 catalytic Zn binding site [ion binding]; other site 1346614013906 structural Zn binding site [ion binding]; other site 1346614013907 dimer interface [polypeptide binding]; other site 1346614013908 maltose O-acetyltransferase; Provisional; Region: PRK10092 1346614013909 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1346614013910 active site 1346614013911 substrate binding site [chemical binding]; other site 1346614013912 trimer interface [polypeptide binding]; other site 1346614013913 CoA binding site [chemical binding]; other site 1346614013914 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1346614013915 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1346614013916 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1346614013917 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1346614013918 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614013919 homodimer interface [polypeptide binding]; other site 1346614013920 catalytic residue [active] 1346614013921 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1346614013922 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1346614013923 putative DNA binding site [nucleotide binding]; other site 1346614013924 putative Zn2+ binding site [ion binding]; other site 1346614013925 AsnC family; Region: AsnC_trans_reg; pfam01037 1346614013926 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1346614013927 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1346614013928 substrate binding pocket [chemical binding]; other site 1346614013929 membrane-bound complex binding site; other site 1346614013930 hinge residues; other site 1346614013931 alanine racemase; Reviewed; Region: alr; PRK00053 1346614013932 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1346614013933 active site 1346614013934 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1346614013935 substrate binding site [chemical binding]; other site 1346614013936 catalytic residues [active] 1346614013937 dimer interface [polypeptide binding]; other site 1346614013938 replicative DNA helicase; Provisional; Region: PRK08006 1346614013939 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1346614013940 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1346614013941 Walker A motif; other site 1346614013942 ATP binding site [chemical binding]; other site 1346614013943 Walker B motif; other site 1346614013944 DNA binding loops [nucleotide binding] 1346614013945 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1346614013946 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1346614013947 NADP binding site [chemical binding]; other site 1346614013948 dimer interface [polypeptide binding]; other site 1346614013949 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1346614013950 phage shock protein G; Reviewed; Region: pspG; PRK09459 1346614013951 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1346614013952 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1346614013953 FMN binding site [chemical binding]; other site 1346614013954 active site 1346614013955 catalytic residues [active] 1346614013956 substrate binding site [chemical binding]; other site 1346614013957 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1346614013958 binding surface 1346614013959 TPR motif; other site 1346614013960 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1346614013961 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1346614013962 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1346614013963 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1346614013964 DNA binding residues [nucleotide binding] 1346614013965 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1346614013966 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1346614013967 metal binding site 2 [ion binding]; metal-binding site 1346614013968 putative DNA binding helix; other site 1346614013969 metal binding site 1 [ion binding]; metal-binding site 1346614013970 dimer interface [polypeptide binding]; other site 1346614013971 structural Zn2+ binding site [ion binding]; other site 1346614013972 hypothetical protein; Provisional; Region: PRK10428 1346614013973 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1346614013974 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1346614013975 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1346614013976 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 1346614013977 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1346614013978 putative acyl-acceptor binding pocket; other site 1346614013979 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1346614013980 UbiA prenyltransferase family; Region: UbiA; pfam01040 1346614013981 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 1346614013982 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614013983 metabolite-proton symporter; Region: 2A0106; TIGR00883 1346614013984 putative substrate translocation pore; other site 1346614013985 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1346614013986 DNA binding site [nucleotide binding] 1346614013987 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1346614013988 domain linker motif; other site 1346614013989 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1346614013990 dimerization interface [polypeptide binding]; other site 1346614013991 ligand binding site [chemical binding]; other site 1346614013992 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 1346614013993 active site 1346614013994 maltose regulon periplasmic protein; Provisional; Region: PRK10564 1346614013995 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1346614013996 trimer interface; other site 1346614013997 sugar binding site [chemical binding]; other site 1346614013998 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 1346614013999 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1346614014000 Walker A/P-loop; other site 1346614014001 ATP binding site [chemical binding]; other site 1346614014002 Q-loop/lid; other site 1346614014003 ABC transporter signature motif; other site 1346614014004 Walker B; other site 1346614014005 D-loop; other site 1346614014006 H-loop/switch region; other site 1346614014007 TOBE domain; Region: TOBE_2; pfam08402 1346614014008 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1346614014009 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1346614014010 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 1346614014011 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1346614014012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614014013 dimer interface [polypeptide binding]; other site 1346614014014 conserved gate region; other site 1346614014015 putative PBP binding loops; other site 1346614014016 ABC-ATPase subunit interface; other site 1346614014017 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1346614014018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614014019 dimer interface [polypeptide binding]; other site 1346614014020 conserved gate region; other site 1346614014021 putative PBP binding loops; other site 1346614014022 ABC-ATPase subunit interface; other site 1346614014023 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 1346614014024 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 1346614014025 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1346614014026 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1346614014027 active site 1346614014028 dimer interface [polypeptide binding]; other site 1346614014029 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1346614014030 dimer interface [polypeptide binding]; other site 1346614014031 active site 1346614014032 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1346614014033 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1346614014034 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1346614014035 TrkA-N domain; Region: TrkA_N; pfam02254 1346614014036 aspartate kinase III; Validated; Region: PRK09084 1346614014037 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1346614014038 nucleotide binding site [chemical binding]; other site 1346614014039 substrate binding site [chemical binding]; other site 1346614014040 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1346614014041 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 1346614014042 dimer interface [polypeptide binding]; other site 1346614014043 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1346614014044 Sodium Bile acid symporter family; Region: SBF; pfam01758 1346614014045 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1346614014046 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1346614014047 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1346614014048 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1346614014049 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1346614014050 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1346614014051 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1346614014052 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1346614014053 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1346614014054 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1346614014055 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1346614014056 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1346614014057 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1346614014058 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1346614014059 Walker A/P-loop; other site 1346614014060 ATP binding site [chemical binding]; other site 1346614014061 Q-loop/lid; other site 1346614014062 ABC transporter signature motif; other site 1346614014063 Walker B; other site 1346614014064 D-loop; other site 1346614014065 H-loop/switch region; other site 1346614014066 TOBE domain; Region: TOBE_2; pfam08402 1346614014067 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1346614014068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614014069 dimer interface [polypeptide binding]; other site 1346614014070 conserved gate region; other site 1346614014071 putative PBP binding loops; other site 1346614014072 ABC-ATPase subunit interface; other site 1346614014073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614014074 dimer interface [polypeptide binding]; other site 1346614014075 conserved gate region; other site 1346614014076 putative PBP binding loops; other site 1346614014077 ABC-ATPase subunit interface; other site 1346614014078 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 1346614014079 PglZ domain; Region: PglZ; pfam08665 1346614014080 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1346614014081 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1346614014082 transcriptional regulator protein; Region: phnR; TIGR03337 1346614014083 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1346614014084 DNA-binding site [nucleotide binding]; DNA binding site 1346614014085 UTRA domain; Region: UTRA; pfam07702 1346614014086 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1346614014087 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1346614014088 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1346614014089 substrate binding pocket [chemical binding]; other site 1346614014090 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1346614014091 B12 binding site [chemical binding]; other site 1346614014092 cobalt ligand [ion binding]; other site 1346614014093 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1346614014094 transcriptional repressor IclR; Provisional; Region: PRK11569 1346614014095 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1346614014096 Bacterial transcriptional regulator; Region: IclR; pfam01614 1346614014097 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1346614014098 DNA-binding site [nucleotide binding]; DNA binding site 1346614014099 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 1346614014100 dimer interface [polypeptide binding]; other site 1346614014101 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 1346614014102 active site 1346614014103 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1346614014104 substrate binding site [chemical binding]; other site 1346614014105 catalytic residue [active] 1346614014106 putative mutase; Provisional; Region: PRK12383 1346614014107 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 1346614014108 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1346614014109 active site 1346614014110 substrate binding pocket [chemical binding]; other site 1346614014111 homodimer interaction site [polypeptide binding]; other site 1346614014112 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 1346614014113 Protein of unknown function; Region: YhfT; pfam10797 1346614014114 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 1346614014115 active site 1346614014116 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1346614014117 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1346614014118 ATP-binding site [chemical binding]; other site 1346614014119 Gluconate-6-phosphate binding site [chemical binding]; other site 1346614014120 low affinity gluconate transporter; Provisional; Region: PRK10472 1346614014121 gluconate transporter; Region: gntP; TIGR00791 1346614014122 phosphogluconate dehydratase; Validated; Region: PRK09054 1346614014123 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1346614014124 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1346614014125 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1346614014126 active site 1346614014127 intersubunit interface [polypeptide binding]; other site 1346614014128 catalytic residue [active] 1346614014129 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 1346614014130 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 1346614014131 isocitrate lyase; Provisional; Region: PRK15063 1346614014132 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1346614014133 tetramer interface [polypeptide binding]; other site 1346614014134 active site 1346614014135 Mg2+/Mn2+ binding site [ion binding]; other site 1346614014136 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1346614014137 malate synthase A; Region: malate_syn_A; TIGR01344 1346614014138 active site 1346614014139 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1346614014140 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1346614014141 proposed active site lysine [active] 1346614014142 conserved cys residue [active] 1346614014143 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1346614014144 HTH-like domain; Region: HTH_21; pfam13276 1346614014145 Integrase core domain; Region: rve; pfam00665 1346614014146 Integrase core domain; Region: rve_3; pfam13683 1346614014147 Transposase; Region: HTH_Tnp_1; pfam01527 1346614014148 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1346614014149 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1346614014150 trimer interface [polypeptide binding]; other site 1346614014151 putative metal binding site [ion binding]; other site 1346614014152 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1346614014153 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1346614014154 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1346614014155 shikimate binding site; other site 1346614014156 NAD(P) binding site [chemical binding]; other site 1346614014157 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1346614014158 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1346614014159 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1346614014160 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1346614014161 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1346614014162 hypothetical protein; Validated; Region: PRK03430 1346614014163 hypothetical protein; Provisional; Region: PRK10736 1346614014164 DNA protecting protein DprA; Region: dprA; TIGR00732 1346614014165 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1346614014166 active site 1346614014167 catalytic residues [active] 1346614014168 metal binding site [ion binding]; metal-binding site 1346614014169 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1346614014170 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1346614014171 putative active site [active] 1346614014172 substrate binding site [chemical binding]; other site 1346614014173 putative cosubstrate binding site; other site 1346614014174 catalytic site [active] 1346614014175 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1346614014176 substrate binding site [chemical binding]; other site 1346614014177 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1346614014178 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1346614014179 putative RNA binding site [nucleotide binding]; other site 1346614014180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614014181 S-adenosylmethionine binding site [chemical binding]; other site 1346614014182 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1346614014183 TrkA-N domain; Region: TrkA_N; pfam02254 1346614014184 TrkA-C domain; Region: TrkA_C; pfam02080 1346614014185 TrkA-N domain; Region: TrkA_N; pfam02254 1346614014186 TrkA-C domain; Region: TrkA_C; pfam02080 1346614014187 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1346614014188 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1346614014189 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 1346614014190 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 1346614014191 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1346614014192 DNA binding residues [nucleotide binding] 1346614014193 dimer interface [polypeptide binding]; other site 1346614014194 metal binding site [ion binding]; metal-binding site 1346614014195 hypothetical protein; Provisional; Region: PRK10203 1346614014196 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1346614014197 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1346614014198 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1346614014199 alphaNTD homodimer interface [polypeptide binding]; other site 1346614014200 alphaNTD - beta interaction site [polypeptide binding]; other site 1346614014201 alphaNTD - beta' interaction site [polypeptide binding]; other site 1346614014202 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1346614014203 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1346614014204 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1346614014205 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1346614014206 RNA binding surface [nucleotide binding]; other site 1346614014207 30S ribosomal protein S11; Validated; Region: PRK05309 1346614014208 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1346614014209 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1346614014210 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1346614014211 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1346614014212 SecY translocase; Region: SecY; pfam00344 1346614014213 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1346614014214 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1346614014215 23S rRNA binding site [nucleotide binding]; other site 1346614014216 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1346614014217 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1346614014218 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1346614014219 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1346614014220 23S rRNA interface [nucleotide binding]; other site 1346614014221 5S rRNA interface [nucleotide binding]; other site 1346614014222 L27 interface [polypeptide binding]; other site 1346614014223 L5 interface [polypeptide binding]; other site 1346614014224 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1346614014225 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1346614014226 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1346614014227 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1346614014228 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1346614014229 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1346614014230 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1346614014231 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1346614014232 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1346614014233 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1346614014234 RNA binding site [nucleotide binding]; other site 1346614014235 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1346614014236 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1346614014237 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1346614014238 23S rRNA interface [nucleotide binding]; other site 1346614014239 putative translocon interaction site; other site 1346614014240 signal recognition particle (SRP54) interaction site; other site 1346614014241 L23 interface [polypeptide binding]; other site 1346614014242 trigger factor interaction site; other site 1346614014243 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1346614014244 23S rRNA interface [nucleotide binding]; other site 1346614014245 5S rRNA interface [nucleotide binding]; other site 1346614014246 putative antibiotic binding site [chemical binding]; other site 1346614014247 L25 interface [polypeptide binding]; other site 1346614014248 L27 interface [polypeptide binding]; other site 1346614014249 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1346614014250 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1346614014251 G-X-X-G motif; other site 1346614014252 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1346614014253 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1346614014254 protein-rRNA interface [nucleotide binding]; other site 1346614014255 putative translocon binding site; other site 1346614014256 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1346614014257 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1346614014258 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1346614014259 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1346614014260 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1346614014261 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1346614014262 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1346614014263 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1346614014264 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1346614014265 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1346614014266 heme binding site [chemical binding]; other site 1346614014267 ferroxidase pore; other site 1346614014268 ferroxidase diiron center [ion binding]; other site 1346614014269 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1346614014270 elongation factor Tu; Reviewed; Region: PRK00049 1346614014271 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1346614014272 G1 box; other site 1346614014273 GEF interaction site [polypeptide binding]; other site 1346614014274 GTP/Mg2+ binding site [chemical binding]; other site 1346614014275 Switch I region; other site 1346614014276 G2 box; other site 1346614014277 G3 box; other site 1346614014278 Switch II region; other site 1346614014279 G4 box; other site 1346614014280 G5 box; other site 1346614014281 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1346614014282 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1346614014283 Antibiotic Binding Site [chemical binding]; other site 1346614014284 elongation factor G; Reviewed; Region: PRK00007 1346614014285 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1346614014286 G1 box; other site 1346614014287 putative GEF interaction site [polypeptide binding]; other site 1346614014288 GTP/Mg2+ binding site [chemical binding]; other site 1346614014289 Switch I region; other site 1346614014290 G2 box; other site 1346614014291 G3 box; other site 1346614014292 Switch II region; other site 1346614014293 G4 box; other site 1346614014294 G5 box; other site 1346614014295 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1346614014296 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1346614014297 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1346614014298 30S ribosomal protein S7; Validated; Region: PRK05302 1346614014299 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1346614014300 S17 interaction site [polypeptide binding]; other site 1346614014301 S8 interaction site; other site 1346614014302 16S rRNA interaction site [nucleotide binding]; other site 1346614014303 streptomycin interaction site [chemical binding]; other site 1346614014304 23S rRNA interaction site [nucleotide binding]; other site 1346614014305 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1346614014306 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 1346614014307 sulfur relay protein TusC; Validated; Region: PRK00211 1346614014308 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 1346614014309 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1346614014310 YheO-like PAS domain; Region: PAS_6; pfam08348 1346614014311 HTH domain; Region: HTH_22; pfam13309 1346614014312 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 1346614014313 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1346614014314 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1346614014315 phi X174 lysis protein; Provisional; Region: PRK02793 1346614014316 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737 1346614014317 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1346614014318 Probable metal-binding protein (DUF2387); Region: DUF2387; cl01410 1346614014319 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 1346614014320 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1346614014321 TrkA-N domain; Region: TrkA_N; pfam02254 1346614014322 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 1346614014323 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1346614014324 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1346614014325 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1346614014326 ABC transporter; Region: ABC_tran_2; pfam12848 1346614014327 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1346614014328 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1346614014329 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 1346614014330 substrate binding pocket [chemical binding]; other site 1346614014331 active site 1346614014332 iron coordination sites [ion binding]; other site 1346614014333 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1346614014334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614014335 dimer interface [polypeptide binding]; other site 1346614014336 conserved gate region; other site 1346614014337 putative PBP binding loops; other site 1346614014338 ABC-ATPase subunit interface; other site 1346614014339 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 1346614014340 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1346614014341 Walker A/P-loop; other site 1346614014342 ATP binding site [chemical binding]; other site 1346614014343 Q-loop/lid; other site 1346614014344 ABC transporter signature motif; other site 1346614014345 Walker B; other site 1346614014346 D-loop; other site 1346614014347 H-loop/switch region; other site 1346614014348 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 1346614014349 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1346614014350 substrate binding pocket [chemical binding]; other site 1346614014351 membrane-bound complex binding site; other site 1346614014352 hinge residues; other site 1346614014353 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1346614014354 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1346614014355 putative hydrolase; Provisional; Region: PRK10985 1346614014356 hypothetical protein; Provisional; Region: PRK04966 1346614014357 phosphoribulokinase; Provisional; Region: PRK15453 1346614014358 hypothetical protein; Provisional; Region: PRK10738 1346614014359 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1346614014360 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1346614014361 ligand binding site [chemical binding]; other site 1346614014362 flexible hinge region; other site 1346614014363 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1346614014364 putative switch regulator; other site 1346614014365 non-specific DNA interactions [nucleotide binding]; other site 1346614014366 DNA binding site [nucleotide binding] 1346614014367 sequence specific DNA binding site [nucleotide binding]; other site 1346614014368 putative cAMP binding site [chemical binding]; other site 1346614014369 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 1346614014370 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1346614014371 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1346614014372 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 1346614014373 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1346614014374 inhibitor-cofactor binding pocket; inhibition site 1346614014375 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614014376 catalytic residue [active] 1346614014377 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1346614014378 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1346614014379 glutamine binding [chemical binding]; other site 1346614014380 catalytic triad [active] 1346614014381 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1346614014382 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1346614014383 Walker A motif; other site 1346614014384 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1346614014385 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 1346614014386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614014387 active site 1346614014388 phosphorylation site [posttranslational modification] 1346614014389 intermolecular recognition site; other site 1346614014390 dimerization interface [polypeptide binding]; other site 1346614014391 LytTr DNA-binding domain; Region: LytTR; smart00850 1346614014392 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1346614014393 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1346614014394 active site 1346614014395 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1346614014396 active site 1346614014397 methionine cluster; other site 1346614014398 phosphorylation site [posttranslational modification] 1346614014399 metal binding site [ion binding]; metal-binding site 1346614014400 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1346614014401 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1346614014402 NAD binding site [chemical binding]; other site 1346614014403 sugar binding site [chemical binding]; other site 1346614014404 divalent metal binding site [ion binding]; other site 1346614014405 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1346614014406 dimer interface [polypeptide binding]; other site 1346614014407 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1346614014408 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1346614014409 DNA binding site [nucleotide binding] 1346614014410 domain linker motif; other site 1346614014411 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1346614014412 dimerization interface (closed form) [polypeptide binding]; other site 1346614014413 ligand binding site [chemical binding]; other site 1346614014414 putative transporter; Provisional; Region: PRK03699 1346614014415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614014416 putative substrate translocation pore; other site 1346614014417 cytosine deaminase; Provisional; Region: PRK09230 1346614014418 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1346614014419 active site 1346614014420 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1346614014421 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1346614014422 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1346614014423 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1346614014424 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1346614014425 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1346614014426 nitrite transporter NirC; Provisional; Region: PRK11562 1346614014427 siroheme synthase; Provisional; Region: cysG; PRK10637 1346614014428 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1346614014429 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1346614014430 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1346614014431 active site 1346614014432 SAM binding site [chemical binding]; other site 1346614014433 homodimer interface [polypeptide binding]; other site 1346614014434 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1346614014435 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1346614014436 active site 1346614014437 HIGH motif; other site 1346614014438 dimer interface [polypeptide binding]; other site 1346614014439 KMSKS motif; other site 1346614014440 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1346614014441 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1346614014442 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1346614014443 motif II; other site 1346614014444 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1346614014445 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1346614014446 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1346614014447 substrate binding site [chemical binding]; other site 1346614014448 hexamer interface [polypeptide binding]; other site 1346614014449 metal binding site [ion binding]; metal-binding site 1346614014450 DNA adenine methylase; Provisional; Region: PRK10904 1346614014451 hypothetical protein; Reviewed; Region: PRK11901 1346614014452 cell division protein DamX; Validated; Region: PRK10905 1346614014453 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1346614014454 active site 1346614014455 dimer interface [polypeptide binding]; other site 1346614014456 metal binding site [ion binding]; metal-binding site 1346614014457 shikimate kinase; Reviewed; Region: aroK; PRK00131 1346614014458 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1346614014459 ADP binding site [chemical binding]; other site 1346614014460 magnesium binding site [ion binding]; other site 1346614014461 putative shikimate binding site; other site 1346614014462 putative outer membrane porin HofQ; Provisional; Region: hofQ; PRK13568 1346614014463 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1346614014464 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1346614014465 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 1346614014466 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1346614014467 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 1346614014468 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 1346614014469 Transglycosylase; Region: Transgly; pfam00912 1346614014470 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1346614014471 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1346614014472 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1346614014473 ADP-ribose binding site [chemical binding]; other site 1346614014474 dimer interface [polypeptide binding]; other site 1346614014475 active site 1346614014476 nudix motif; other site 1346614014477 metal binding site [ion binding]; metal-binding site 1346614014478 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 1346614014479 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1346614014480 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1346614014481 motif II; other site 1346614014482 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1346614014483 RNA binding surface [nucleotide binding]; other site 1346614014484 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1346614014485 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1346614014486 dimerization interface [polypeptide binding]; other site 1346614014487 domain crossover interface; other site 1346614014488 redox-dependent activation switch; other site 1346614014489 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1346614014490 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1346614014491 active site 1346614014492 substrate-binding site [chemical binding]; other site 1346614014493 metal-binding site [ion binding] 1346614014494 ATP binding site [chemical binding]; other site 1346614014495 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1346614014496 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1346614014497 oligomeric interface; other site 1346614014498 putative active site [active] 1346614014499 homodimer interface [polypeptide binding]; other site 1346614014500 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1346614014501 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1346614014502 dimerization interface [polypeptide binding]; other site 1346614014503 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1346614014504 dimer interface [polypeptide binding]; other site 1346614014505 phosphorylation site [posttranslational modification] 1346614014506 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614014507 ATP binding site [chemical binding]; other site 1346614014508 G-X-G motif; other site 1346614014509 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1346614014510 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614014511 active site 1346614014512 phosphorylation site [posttranslational modification] 1346614014513 intermolecular recognition site; other site 1346614014514 dimerization interface [polypeptide binding]; other site 1346614014515 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1346614014516 DNA binding site [nucleotide binding] 1346614014517 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1346614014518 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1346614014519 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1346614014520 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1346614014521 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1346614014522 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1346614014523 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1346614014524 RNA binding site [nucleotide binding]; other site 1346614014525 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 1346614014526 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 1346614014527 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1346614014528 G1 box; other site 1346614014529 GTP/Mg2+ binding site [chemical binding]; other site 1346614014530 Switch I region; other site 1346614014531 G2 box; other site 1346614014532 G3 box; other site 1346614014533 Switch II region; other site 1346614014534 G4 box; other site 1346614014535 G5 box; other site 1346614014536 Nucleoside recognition; Region: Gate; pfam07670 1346614014537 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1346614014538 Nucleoside recognition; Region: Gate; pfam07670 1346614014539 FeoC like transcriptional regulator; Region: FeoC; cl17677 1346614014540 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1346614014541 carboxylesterase BioH; Provisional; Region: PRK10349 1346614014542 comF family protein; Region: comF; TIGR00201 1346614014543 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1346614014544 active site 1346614014545 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 1346614014546 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1346614014547 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1346614014548 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1346614014549 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1346614014550 maltodextrin phosphorylase; Provisional; Region: PRK14985 1346614014551 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1346614014552 active site pocket [active] 1346614014553 transcriptional regulator MalT; Provisional; Region: PRK04841 1346614014554 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1346614014555 DNA binding residues [nucleotide binding] 1346614014556 dimerization interface [polypeptide binding]; other site 1346614014557 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614014558 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1346614014559 Coenzyme A binding pocket [chemical binding]; other site 1346614014560 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1346614014561 active site residue [active] 1346614014562 intramembrane serine protease GlpG; Provisional; Region: PRK10907 1346614014563 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 1346614014564 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1346614014565 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 1346614014566 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1346614014567 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1346614014568 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1346614014569 glycogen phosphorylase; Provisional; Region: PRK14986 1346614014570 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1346614014571 homodimer interface [polypeptide binding]; other site 1346614014572 active site pocket [active] 1346614014573 glycogen synthase; Provisional; Region: glgA; PRK00654 1346614014574 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1346614014575 ADP-binding pocket [chemical binding]; other site 1346614014576 homodimer interface [polypeptide binding]; other site 1346614014577 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 1346614014578 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1346614014579 ligand binding site; other site 1346614014580 oligomer interface; other site 1346614014581 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1346614014582 sulfate 1 binding site; other site 1346614014583 glycogen debranching enzyme; Provisional; Region: PRK03705 1346614014584 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1346614014585 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1346614014586 active site 1346614014587 catalytic site [active] 1346614014588 glycogen branching enzyme; Provisional; Region: PRK05402 1346614014589 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1346614014590 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1346614014591 active site 1346614014592 catalytic site [active] 1346614014593 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1346614014594 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1346614014595 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1346614014596 putative antibiotic transporter; Provisional; Region: PRK10739 1346614014597 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1346614014598 high-affinity gluconate transporter; Provisional; Region: PRK14984 1346614014599 gluconate transporter; Region: gntP; TIGR00791 1346614014600 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 1346614014601 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1346614014602 DNA binding site [nucleotide binding] 1346614014603 domain linker motif; other site 1346614014604 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1346614014605 putative ligand binding site [chemical binding]; other site 1346614014606 putative dimerization interface [polypeptide binding]; other site 1346614014607 Pirin-related protein [General function prediction only]; Region: COG1741 1346614014608 Pirin; Region: Pirin; pfam02678 1346614014609 putative acetyltransferase YhhY; Provisional; Region: PRK10140 1346614014610 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1346614014611 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1346614014612 putative active site pocket [active] 1346614014613 cleavage site 1346614014614 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1346614014615 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1346614014616 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1346614014617 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1346614014618 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1346614014619 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1346614014620 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1346614014621 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1346614014622 PYR/PP interface [polypeptide binding]; other site 1346614014623 dimer interface [polypeptide binding]; other site 1346614014624 TPP binding site [chemical binding]; other site 1346614014625 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1346614014626 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1346614014627 TPP-binding site; other site 1346614014628 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1346614014629 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1346614014630 substrate binding site [chemical binding]; other site 1346614014631 ATP binding site [chemical binding]; other site 1346614014632 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 1346614014633 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 1346614014634 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1346614014635 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1346614014636 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1346614014637 putative active site [active] 1346614014638 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 1346614014639 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1346614014640 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1346614014641 tetrameric interface [polypeptide binding]; other site 1346614014642 NAD binding site [chemical binding]; other site 1346614014643 catalytic residues [active] 1346614014644 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1346614014645 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614014646 putative substrate translocation pore; other site 1346614014647 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614014648 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 1346614014649 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1346614014650 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 1346614014651 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1346614014652 Walker A/P-loop; other site 1346614014653 ATP binding site [chemical binding]; other site 1346614014654 Q-loop/lid; other site 1346614014655 ABC transporter signature motif; other site 1346614014656 Walker B; other site 1346614014657 D-loop; other site 1346614014658 H-loop/switch region; other site 1346614014659 FaeA-like protein; Region: FaeA; pfam04703 1346614014660 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1346614014661 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1346614014662 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1346614014663 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1346614014664 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1346614014665 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 1346614014666 PapC N-terminal domain; Region: PapC_N; pfam13954 1346614014667 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1346614014668 PapC C-terminal domain; Region: PapC_C; pfam13953 1346614014669 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1346614014670 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1346614014671 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1346614014672 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1346614014673 Fimbrial protein; Region: Fimbrial; cl01416 1346614014674 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1346614014675 O-Antigen ligase; Region: Wzy_C; pfam04932 1346614014676 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1346614014677 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 1346614014678 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1346614014679 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1346614014680 DNA binding residues [nucleotide binding] 1346614014681 dimerization interface [polypeptide binding]; other site 1346614014682 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 1346614014683 Amidinotransferase; Region: Amidinotransf; pfam02274 1346614014684 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1346614014685 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1346614014686 putative DNA binding site [nucleotide binding]; other site 1346614014687 putative Zn2+ binding site [ion binding]; other site 1346614014688 AsnC family; Region: AsnC_trans_reg; pfam01037 1346614014689 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 1346614014690 active site 1346614014691 metal binding site [ion binding]; metal-binding site 1346614014692 Virulence factor SrfB; Region: SrfB; pfam07520 1346614014693 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 1346614014694 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 1346614014695 dimer interface [polypeptide binding]; other site 1346614014696 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1346614014697 metal binding site [ion binding]; metal-binding site 1346614014698 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 1346614014699 Predicted flavoproteins [General function prediction only]; Region: COG2081 1346614014700 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1346614014701 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1346614014702 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1346614014703 universal stress protein UspB; Provisional; Region: PRK04960 1346614014704 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1346614014705 Ligand Binding Site [chemical binding]; other site 1346614014706 glutamate dehydrogenase; Provisional; Region: PRK09414 1346614014707 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1346614014708 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1346614014709 NAD(P) binding site [chemical binding]; other site 1346614014710 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1346614014711 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1346614014712 ligand binding site [chemical binding]; other site 1346614014713 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1346614014714 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1346614014715 Walker A/P-loop; other site 1346614014716 ATP binding site [chemical binding]; other site 1346614014717 Q-loop/lid; other site 1346614014718 ABC transporter signature motif; other site 1346614014719 Walker B; other site 1346614014720 D-loop; other site 1346614014721 H-loop/switch region; other site 1346614014722 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1346614014723 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1346614014724 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1346614014725 TM-ABC transporter signature motif; other site 1346614014726 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1346614014727 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1346614014728 TM-ABC transporter signature motif; other site 1346614014729 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 1346614014730 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 1346614014731 N- and C-terminal domain interface [polypeptide binding]; other site 1346614014732 active site 1346614014733 MgATP binding site [chemical binding]; other site 1346614014734 catalytic site [active] 1346614014735 metal binding site [ion binding]; metal-binding site 1346614014736 carbohydrate binding site [chemical binding]; other site 1346614014737 putative homodimer interface [polypeptide binding]; other site 1346614014738 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1346614014739 putative active site [active] 1346614014740 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Region: CycNucDiestase; TIGR01390 1346614014741 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1346614014742 active site 1346614014743 metal binding site [ion binding]; metal-binding site 1346614014744 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1346614014745 putative methyltransferase; Provisional; Region: PRK10742 1346614014746 oligopeptidase A; Provisional; Region: PRK10911 1346614014747 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1346614014748 active site 1346614014749 Zn binding site [ion binding]; other site 1346614014750 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1346614014751 nucleotide binding site/active site [active] 1346614014752 HIT family signature motif; other site 1346614014753 catalytic residue [active] 1346614014754 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1346614014755 Amidase; Region: Amidase; cl11426 1346614014756 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1346614014757 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614014758 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1346614014759 dimerization interface [polypeptide binding]; other site 1346614014760 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1346614014761 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1346614014762 glutathione reductase; Validated; Region: PRK06116 1346614014763 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1346614014764 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1346614014765 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1346614014766 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1346614014767 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1346614014768 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1346614014769 dimer interface [polypeptide binding]; other site 1346614014770 phosphorylation site [posttranslational modification] 1346614014771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614014772 ATP binding site [chemical binding]; other site 1346614014773 Mg2+ binding site [ion binding]; other site 1346614014774 G-X-G motif; other site 1346614014775 Response regulator receiver domain; Region: Response_reg; pfam00072 1346614014776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614014777 active site 1346614014778 phosphorylation site [posttranslational modification] 1346614014779 intermolecular recognition site; other site 1346614014780 dimerization interface [polypeptide binding]; other site 1346614014781 BetR domain; Region: BetR; pfam08667 1346614014782 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1346614014783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614014784 active site 1346614014785 phosphorylation site [posttranslational modification] 1346614014786 intermolecular recognition site; other site 1346614014787 dimerization interface [polypeptide binding]; other site 1346614014788 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 1346614014789 catalytic triad [active] 1346614014790 putative active site [active] 1346614014791 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1346614014792 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1346614014793 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1346614014794 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 1346614014795 catalytic triad [active] 1346614014796 putative active site [active] 1346614014797 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1346614014798 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1346614014799 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1346614014800 Uncharacterized conserved protein [Function unknown]; Region: COG5441; cl02262 1346614014801 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1346614014802 dimer interface [polypeptide binding]; other site 1346614014803 RNase II stability modulator; Provisional; Region: PRK10060 1346614014804 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1346614014805 putative active site [active] 1346614014806 heme pocket [chemical binding]; other site 1346614014807 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1346614014808 metal binding site [ion binding]; metal-binding site 1346614014809 active site 1346614014810 I-site; other site 1346614014811 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1346614014812 enoyl-CoA hydratase; Validated; Region: PRK08788 1346614014813 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1346614014814 substrate binding site [chemical binding]; other site 1346614014815 oxyanion hole (OAH) forming residues; other site 1346614014816 trimer interface [polypeptide binding]; other site 1346614014817 inner membrane protein YhjD; Region: TIGR00766 1346614014818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614014819 metabolite-proton symporter; Region: 2A0106; TIGR00883 1346614014820 putative substrate translocation pore; other site 1346614014821 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 1346614014822 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1346614014823 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1346614014824 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1346614014825 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1346614014826 active site 1 [active] 1346614014827 dimer interface [polypeptide binding]; other site 1346614014828 hexamer interface [polypeptide binding]; other site 1346614014829 active site 2 [active] 1346614014830 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1346614014831 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1346614014832 substrate binding site [chemical binding]; other site 1346614014833 ATP binding site [chemical binding]; other site 1346614014834 ketol-acid reductoisomerase; Validated; Region: PRK05225 1346614014835 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1346614014836 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1346614014837 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1346614014838 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614014839 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 1346614014840 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 1346614014841 putative dimerization interface [polypeptide binding]; other site 1346614014842 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 1346614014843 threonine dehydratase; Reviewed; Region: PRK09224 1346614014844 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1346614014845 tetramer interface [polypeptide binding]; other site 1346614014846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614014847 catalytic residue [active] 1346614014848 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1346614014849 putative Ile/Val binding site [chemical binding]; other site 1346614014850 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1346614014851 putative Ile/Val binding site [chemical binding]; other site 1346614014852 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1346614014853 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1346614014854 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1346614014855 homodimer interface [polypeptide binding]; other site 1346614014856 substrate-cofactor binding pocket; other site 1346614014857 catalytic residue [active] 1346614014858 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 1346614014859 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 1346614014860 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1346614014861 PYR/PP interface [polypeptide binding]; other site 1346614014862 dimer interface [polypeptide binding]; other site 1346614014863 TPP binding site [chemical binding]; other site 1346614014864 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1346614014865 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1346614014866 TPP-binding site [chemical binding]; other site 1346614014867 dimer interface [polypeptide binding]; other site 1346614014868 putative sialic acid transporter; Region: 2A0112; TIGR00891 1346614014869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614014870 putative substrate translocation pore; other site 1346614014871 putative ATP-dependent protease; Provisional; Region: PRK09862 1346614014872 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1346614014873 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1346614014874 Walker A motif; other site 1346614014875 ATP binding site [chemical binding]; other site 1346614014876 Walker B motif; other site 1346614014877 arginine finger; other site 1346614014878 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1346614014879 hypothetical protein; Provisional; Region: PRK11027 1346614014880 transcriptional regulator HdfR; Provisional; Region: PRK03601 1346614014881 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614014882 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1346614014883 dimerization interface [polypeptide binding]; other site 1346614014884 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1346614014885 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1346614014886 TM-ABC transporter signature motif; other site 1346614014887 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1346614014888 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1346614014889 TM-ABC transporter signature motif; other site 1346614014890 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1346614014891 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1346614014892 Walker A/P-loop; other site 1346614014893 ATP binding site [chemical binding]; other site 1346614014894 Q-loop/lid; other site 1346614014895 ABC transporter signature motif; other site 1346614014896 Walker B; other site 1346614014897 D-loop; other site 1346614014898 H-loop/switch region; other site 1346614014899 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1346614014900 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1346614014901 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 1346614014902 putative ligand binding site [chemical binding]; other site 1346614014903 glutamate racemase; Provisional; Region: PRK00865 1346614014904 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 1346614014905 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1346614014906 N-terminal plug; other site 1346614014907 ligand-binding site [chemical binding]; other site 1346614014908 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 1346614014909 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614014910 S-adenosylmethionine binding site [chemical binding]; other site 1346614014911 hypothetical protein; Provisional; Region: PRK11056 1346614014912 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1346614014913 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1346614014914 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1346614014915 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1346614014916 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1346614014917 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1346614014918 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1346614014919 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1346614014920 dimerization interface [polypeptide binding]; other site 1346614014921 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 1346614014922 catalytic triad [active] 1346614014923 dimer interface [polypeptide binding]; other site 1346614014924 Glutaredoxin (GRX) family, PRX5 hybrid subfamily; composed of hybrid proteins containing peroxiredoxin (PRX) and GRX domains, which is found in some pathogenic bacteria and cyanobacteria. PRXs are thiol-specific antioxidant (TSA) proteins that confer a...; Region: GRX_hybridPRX5; cd03029 1346614014925 GSH binding site [chemical binding]; other site 1346614014926 catalytic residues [active] 1346614014927 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 1346614014928 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1346614014929 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1346614014930 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1346614014931 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 1346614014932 HicB family; Region: HicB; pfam05534 1346614014933 argininosuccinate lyase; Provisional; Region: PRK04833 1346614014934 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1346614014935 active sites [active] 1346614014936 tetramer interface [polypeptide binding]; other site 1346614014937 argininosuccinate synthase; Provisional; Region: PRK13820 1346614014938 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1346614014939 ANP binding site [chemical binding]; other site 1346614014940 Substrate Binding Site II [chemical binding]; other site 1346614014941 Substrate Binding Site I [chemical binding]; other site 1346614014942 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 1346614014943 nucleotide binding site [chemical binding]; other site 1346614014944 N-acetyl-L-glutamate binding site [chemical binding]; other site 1346614014945 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1346614014946 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1346614014947 acetylornithine deacetylase; Provisional; Region: PRK05111 1346614014948 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1346614014949 metal binding site [ion binding]; metal-binding site 1346614014950 putative dimer interface [polypeptide binding]; other site 1346614014951 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1346614014952 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1346614014953 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1346614014954 FAD binding site [chemical binding]; other site 1346614014955 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 1346614014956 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1346614014957 putative catalytic residues [active] 1346614014958 putative nucleotide binding site [chemical binding]; other site 1346614014959 putative aspartate binding site [chemical binding]; other site 1346614014960 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1346614014961 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1346614014962 cystathionine gamma-synthase; Provisional; Region: PRK08045 1346614014963 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1346614014964 homodimer interface [polypeptide binding]; other site 1346614014965 substrate-cofactor binding pocket; other site 1346614014966 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614014967 catalytic residue [active] 1346614014968 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 1346614014969 dimerization interface [polypeptide binding]; other site 1346614014970 DNA binding site [nucleotide binding] 1346614014971 corepressor binding sites; other site 1346614014972 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1346614014973 primosome assembly protein PriA; Validated; Region: PRK05580 1346614014974 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1346614014975 ATP binding site [chemical binding]; other site 1346614014976 putative Mg++ binding site [ion binding]; other site 1346614014977 DAN domain; Region: DAN; cl17734 1346614014978 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1346614014979 ATP-binding site [chemical binding]; other site 1346614014980 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1346614014981 DNA binding site [nucleotide binding] 1346614014982 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 1346614014983 domain linker motif; other site 1346614014984 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 1346614014985 dimerization interface [polypeptide binding]; other site 1346614014986 ligand binding site [chemical binding]; other site 1346614014987 Sporulation related domain; Region: SPOR; cl10051 1346614014988 Sporulation related domain; Region: SPOR; cl10051 1346614014989 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1346614014990 active site 1346614014991 HslU subunit interaction site [polypeptide binding]; other site 1346614014992 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1346614014993 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1346614014994 Walker A motif; other site 1346614014995 ATP binding site [chemical binding]; other site 1346614014996 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1346614014997 Walker B motif; other site 1346614014998 arginine finger; other site 1346614014999 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1346614015000 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1346614015001 UbiA prenyltransferase family; Region: UbiA; pfam01040 1346614015002 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1346614015003 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3074 1346614015004 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1346614015005 amphipathic channel; other site 1346614015006 Asn-Pro-Ala signature motifs; other site 1346614015007 glycerol kinase; Provisional; Region: glpK; PRK00047 1346614015008 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1346614015009 N- and C-terminal domain interface [polypeptide binding]; other site 1346614015010 active site 1346614015011 MgATP binding site [chemical binding]; other site 1346614015012 catalytic site [active] 1346614015013 metal binding site [ion binding]; metal-binding site 1346614015014 glycerol binding site [chemical binding]; other site 1346614015015 homotetramer interface [polypeptide binding]; other site 1346614015016 homodimer interface [polypeptide binding]; other site 1346614015017 FBP binding site [chemical binding]; other site 1346614015018 protein IIAGlc interface [polypeptide binding]; other site 1346614015019 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1346614015020 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1346614015021 putative active site [active] 1346614015022 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 1346614015023 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614015024 putative substrate translocation pore; other site 1346614015025 Predicted transcriptional regulator [Transcription]; Region: COG2345 1346614015026 MarR family; Region: MarR_2; cl17246 1346614015027 ferredoxin-NADP reductase; Provisional; Region: PRK10926 1346614015028 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1346614015029 FAD binding pocket [chemical binding]; other site 1346614015030 FAD binding motif [chemical binding]; other site 1346614015031 phosphate binding motif [ion binding]; other site 1346614015032 beta-alpha-beta structure motif; other site 1346614015033 NAD binding pocket [chemical binding]; other site 1346614015034 Protein of unknown function (DUF805); Region: DUF805; cl01224 1346614015035 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 1346614015036 triosephosphate isomerase; Provisional; Region: PRK14567 1346614015037 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1346614015038 substrate binding site [chemical binding]; other site 1346614015039 dimer interface [polypeptide binding]; other site 1346614015040 catalytic triad [active] 1346614015041 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1346614015042 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1346614015043 substrate binding pocket [chemical binding]; other site 1346614015044 membrane-bound complex binding site; other site 1346614015045 hinge residues; other site 1346614015046 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1346614015047 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1346614015048 active site 1346614015049 ADP/pyrophosphate binding site [chemical binding]; other site 1346614015050 dimerization interface [polypeptide binding]; other site 1346614015051 allosteric effector site; other site 1346614015052 fructose-1,6-bisphosphate binding site; other site 1346614015053 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 1346614015054 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1346614015055 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1346614015056 dimer interface [polypeptide binding]; other site 1346614015057 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 1346614015058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614015059 active site 1346614015060 phosphorylation site [posttranslational modification] 1346614015061 intermolecular recognition site; other site 1346614015062 dimerization interface [polypeptide binding]; other site 1346614015063 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1346614015064 DNA binding site [nucleotide binding] 1346614015065 two-component sensor protein; Provisional; Region: cpxA; PRK09470 1346614015066 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1346614015067 dimerization interface [polypeptide binding]; other site 1346614015068 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1346614015069 dimer interface [polypeptide binding]; other site 1346614015070 phosphorylation site [posttranslational modification] 1346614015071 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614015072 ATP binding site [chemical binding]; other site 1346614015073 Mg2+ binding site [ion binding]; other site 1346614015074 G-X-G motif; other site 1346614015075 putative rRNA methylase; Provisional; Region: PRK10358 1346614015076 CHAD domain; Region: CHAD; pfam05235 1346614015077 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1346614015078 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1346614015079 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1346614015080 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1346614015081 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 1346614015082 SecA binding site; other site 1346614015083 Preprotein binding site; other site 1346614015084 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1346614015085 GSH binding site [chemical binding]; other site 1346614015086 catalytic residues [active] 1346614015087 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1346614015088 active site residue [active] 1346614015089 phosphoglyceromutase; Provisional; Region: PRK05434 1346614015090 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1346614015091 AmiB activator; Provisional; Region: PRK11637 1346614015092 Peptidase family M23; Region: Peptidase_M23; pfam01551 1346614015093 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1346614015094 NodB motif; other site 1346614015095 putative active site [active] 1346614015096 putative catalytic site [active] 1346614015097 Zn binding site [ion binding]; other site 1346614015098 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1346614015099 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1346614015100 NAD(P) binding site [chemical binding]; other site 1346614015101 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1346614015102 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1346614015103 substrate-cofactor binding pocket; other site 1346614015104 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1346614015105 catalytic residue [active] 1346614015106 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1346614015107 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 1346614015108 NADP binding site [chemical binding]; other site 1346614015109 homopentamer interface [polypeptide binding]; other site 1346614015110 substrate binding site [chemical binding]; other site 1346614015111 active site 1346614015112 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1346614015113 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1346614015114 putative active site [active] 1346614015115 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1346614015116 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1346614015117 putative active site [active] 1346614015118 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1346614015119 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1346614015120 putative glycosyl transferase; Provisional; Region: PRK10073 1346614015121 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1346614015122 active site 1346614015123 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1346614015124 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1346614015125 putative active site [active] 1346614015126 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 1346614015127 putative active site [active] 1346614015128 putative catalytic site [active] 1346614015129 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 1346614015130 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1346614015131 putative active site [active] 1346614015132 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1346614015133 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1346614015134 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1346614015135 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1346614015136 putative active site [active] 1346614015137 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1346614015138 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1346614015139 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 1346614015140 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1346614015141 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1346614015142 putative metal binding site; other site 1346614015143 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1346614015144 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1346614015145 active site 1346614015146 (T/H)XGH motif; other site 1346614015147 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1346614015148 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1346614015149 DNA binding site [nucleotide binding] 1346614015150 catalytic residue [active] 1346614015151 H2TH interface [polypeptide binding]; other site 1346614015152 putative catalytic residues [active] 1346614015153 turnover-facilitating residue; other site 1346614015154 intercalation triad [nucleotide binding]; other site 1346614015155 8OG recognition residue [nucleotide binding]; other site 1346614015156 putative reading head residues; other site 1346614015157 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1346614015158 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1346614015159 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1346614015160 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1346614015161 hypothetical protein; Reviewed; Region: PRK00024 1346614015162 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1346614015163 MPN+ (JAMM) motif; other site 1346614015164 Zinc-binding site [ion binding]; other site 1346614015165 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1346614015166 Flavoprotein; Region: Flavoprotein; pfam02441 1346614015167 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1346614015168 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1346614015169 trimer interface [polypeptide binding]; other site 1346614015170 active site 1346614015171 division inhibitor protein; Provisional; Region: slmA; PRK09480 1346614015172 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1346614015173 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1346614015174 active site 1346614015175 ribonuclease PH; Reviewed; Region: rph; PRK00173 1346614015176 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1346614015177 hexamer interface [polypeptide binding]; other site 1346614015178 active site 1346614015179 hypothetical protein; Provisional; Region: PRK11820 1346614015180 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1346614015181 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1346614015182 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1346614015183 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1346614015184 NAD(P) binding site [chemical binding]; other site 1346614015185 active site 1346614015186 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1346614015187 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1346614015188 Nucleoside recognition; Region: Gate; pfam07670 1346614015189 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1346614015190 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 1346614015191 Predicted membrane protein [Function unknown]; Region: COG2860 1346614015192 UPF0126 domain; Region: UPF0126; pfam03458 1346614015193 UPF0126 domain; Region: UPF0126; pfam03458 1346614015194 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1346614015195 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1346614015196 catalytic site [active] 1346614015197 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1346614015198 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 1346614015199 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1346614015200 Zn2+ binding site [ion binding]; other site 1346614015201 Mg2+ binding site [ion binding]; other site 1346614015202 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1346614015203 synthetase active site [active] 1346614015204 NTP binding site [chemical binding]; other site 1346614015205 metal binding site [ion binding]; metal-binding site 1346614015206 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1346614015207 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1346614015208 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 1346614015209 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1346614015210 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 1346614015211 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1346614015212 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1346614015213 generic binding surface II; other site 1346614015214 ssDNA binding site; other site 1346614015215 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1346614015216 ATP binding site [chemical binding]; other site 1346614015217 putative Mg++ binding site [ion binding]; other site 1346614015218 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1346614015219 nucleotide binding region [chemical binding]; other site 1346614015220 ATP-binding site [chemical binding]; other site 1346614015221 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 1346614015222 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1346614015223 AsmA family; Region: AsmA; pfam05170 1346614015224 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614015225 Coenzyme A binding pocket [chemical binding]; other site 1346614015226 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 1346614015227 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1346614015228 putative active site [active] 1346614015229 dimerization interface [polypeptide binding]; other site 1346614015230 putative tRNAtyr binding site [nucleotide binding]; other site 1346614015231 hypothetical protein; Reviewed; Region: PRK01637 1346614015232 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1346614015233 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1346614015234 motif II; other site 1346614015235 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1346614015236 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1346614015237 G1 box; other site 1346614015238 putative GEF interaction site [polypeptide binding]; other site 1346614015239 GTP/Mg2+ binding site [chemical binding]; other site 1346614015240 Switch I region; other site 1346614015241 G2 box; other site 1346614015242 G3 box; other site 1346614015243 Switch II region; other site 1346614015244 G4 box; other site 1346614015245 G5 box; other site 1346614015246 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1346614015247 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1346614015248 glutamine synthetase; Provisional; Region: glnA; PRK09469 1346614015249 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1346614015250 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1346614015251 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 1346614015252 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1346614015253 dimer interface [polypeptide binding]; other site 1346614015254 phosphorylation site [posttranslational modification] 1346614015255 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614015256 ATP binding site [chemical binding]; other site 1346614015257 Mg2+ binding site [ion binding]; other site 1346614015258 G-X-G motif; other site 1346614015259 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 1346614015260 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1346614015261 active site 1346614015262 phosphorylation site [posttranslational modification] 1346614015263 intermolecular recognition site; other site 1346614015264 dimerization interface [polypeptide binding]; other site 1346614015265 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1346614015266 Walker A motif; other site 1346614015267 ATP binding site [chemical binding]; other site 1346614015268 Walker B motif; other site 1346614015269 arginine finger; other site 1346614015270 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1346614015271 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1346614015272 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1346614015273 FeS/SAM binding site; other site 1346614015274 HemN C-terminal domain; Region: HemN_C; pfam06969 1346614015275 Der GTPase activator; Provisional; Region: PRK05244 1346614015276 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1346614015277 G1 box; other site 1346614015278 GTP/Mg2+ binding site [chemical binding]; other site 1346614015279 Switch I region; other site 1346614015280 G2 box; other site 1346614015281 G3 box; other site 1346614015282 Switch II region; other site 1346614015283 G4 box; other site 1346614015284 G5 box; other site 1346614015285 DNA polymerase I; Provisional; Region: PRK05755 1346614015286 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1346614015287 active site 1346614015288 metal binding site 1 [ion binding]; metal-binding site 1346614015289 putative 5' ssDNA interaction site; other site 1346614015290 metal binding site 3; metal-binding site 1346614015291 metal binding site 2 [ion binding]; metal-binding site 1346614015292 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1346614015293 putative DNA binding site [nucleotide binding]; other site 1346614015294 putative metal binding site [ion binding]; other site 1346614015295 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1346614015296 active site 1346614015297 catalytic site [active] 1346614015298 substrate binding site [chemical binding]; other site 1346614015299 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1346614015300 active site 1346614015301 DNA binding site [nucleotide binding] 1346614015302 catalytic site [active] 1346614015303 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1346614015304 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1346614015305 putative acyl-acceptor binding pocket; other site 1346614015306 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1346614015307 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1346614015308 catalytic residues [active] 1346614015309 hinge region; other site 1346614015310 alpha helical domain; other site 1346614015311 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1346614015312 serine/threonine protein kinase; Provisional; Region: PRK11768 1346614015313 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 1346614015314 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1346614015315 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1346614015316 GTP binding site; other site 1346614015317 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1346614015318 Walker A motif; other site 1346614015319 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1346614015320 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1346614015321 DNA-binding site [nucleotide binding]; DNA binding site 1346614015322 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1346614015323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1346614015324 putative transporter; Provisional; Region: PRK10504 1346614015325 putative substrate translocation pore; other site 1346614015326 transcriptional repressor RbsR; Provisional; Region: PRK10423 1346614015327 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1346614015328 DNA binding site [nucleotide binding] 1346614015329 domain linker motif; other site 1346614015330 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1346614015331 dimerization interface [polypeptide binding]; other site 1346614015332 ligand binding site [chemical binding]; other site 1346614015333 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1346614015334 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1346614015335 substrate binding site [chemical binding]; other site 1346614015336 dimer interface [polypeptide binding]; other site 1346614015337 ATP binding site [chemical binding]; other site 1346614015338 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1346614015339 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1346614015340 ligand binding site [chemical binding]; other site 1346614015341 dimerization interface [polypeptide binding]; other site 1346614015342 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1346614015343 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1346614015344 TM-ABC transporter signature motif; other site 1346614015345 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 1346614015346 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1346614015347 Walker A/P-loop; other site 1346614015348 ATP binding site [chemical binding]; other site 1346614015349 Q-loop/lid; other site 1346614015350 ABC transporter signature motif; other site 1346614015351 Walker B; other site 1346614015352 D-loop; other site 1346614015353 H-loop/switch region; other site 1346614015354 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1346614015355 D-ribose pyranase; Provisional; Region: PRK11797 1346614015356 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 1346614015357 potassium uptake protein; Region: kup; TIGR00794 1346614015358 regulatory ATPase RavA; Provisional; Region: PRK13531 1346614015359 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1346614015360 Walker A motif; other site 1346614015361 ATP binding site [chemical binding]; other site 1346614015362 Walker B motif; other site 1346614015363 arginine finger; other site 1346614015364 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 1346614015365 hypothetical protein; Provisional; Region: yieM; PRK10997 1346614015366 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1346614015367 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1346614015368 metal ion-dependent adhesion site (MIDAS); other site 1346614015369 Asparagine synthetase A [Amino acid transport and metabolism]; Region: AsnA; COG2502 1346614015370 motif 1; other site 1346614015371 dimer interface [polypeptide binding]; other site 1346614015372 active site 1346614015373 motif 2; other site 1346614015374 motif 3; other site 1346614015375 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 1346614015376 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1346614015377 dimerization interface [polypeptide binding]; other site 1346614015378 putative DNA binding site [nucleotide binding]; other site 1346614015379 putative Zn2+ binding site [ion binding]; other site 1346614015380 AsnC family; Region: AsnC_trans_reg; pfam01037 1346614015381 FMN-binding protein MioC; Provisional; Region: PRK09004 1346614015382 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1346614015383 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1346614015384 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1346614015385 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1346614015386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1346614015387 S-adenosylmethionine binding site [chemical binding]; other site 1346614015388 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 1346614015389 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1346614015390 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1346614015391 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1346614015392 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1346614015393 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1346614015394 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1346614015395 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1346614015396 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1346614015397 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1346614015398 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1346614015399 beta subunit interaction interface [polypeptide binding]; other site 1346614015400 Walker A motif; other site 1346614015401 ATP binding site [chemical binding]; other site 1346614015402 Walker B motif; other site 1346614015403 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1346614015404 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1346614015405 core domain interface [polypeptide binding]; other site 1346614015406 delta subunit interface [polypeptide binding]; other site 1346614015407 epsilon subunit interface [polypeptide binding]; other site 1346614015408 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1346614015409 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1346614015410 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1346614015411 alpha subunit interaction interface [polypeptide binding]; other site 1346614015412 Walker A motif; other site 1346614015413 ATP binding site [chemical binding]; other site 1346614015414 Walker B motif; other site 1346614015415 inhibitor binding site; inhibition site 1346614015416 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1346614015417 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1346614015418 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1346614015419 gamma subunit interface [polypeptide binding]; other site 1346614015420 epsilon subunit interface [polypeptide binding]; other site 1346614015421 LBP interface [polypeptide binding]; other site 1346614015422 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 1346614015423 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1346614015424 Substrate binding site; other site 1346614015425 Mg++ binding site; other site 1346614015426 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1346614015427 active site 1346614015428 substrate binding site [chemical binding]; other site 1346614015429 CoA binding site [chemical binding]; other site 1346614015430 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1346614015431 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1346614015432 glutaminase active site [active] 1346614015433 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1346614015434 dimer interface [polypeptide binding]; other site 1346614015435 active site 1346614015436 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1346614015437 dimer interface [polypeptide binding]; other site 1346614015438 active site 1346614015439 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1346614015440 substrate binding pocket [chemical binding]; other site 1346614015441 membrane-bound complex binding site; other site 1346614015442 hinge residues; other site 1346614015443 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 1346614015444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614015445 dimer interface [polypeptide binding]; other site 1346614015446 conserved gate region; other site 1346614015447 putative PBP binding loops; other site 1346614015448 ABC-ATPase subunit interface; other site 1346614015449 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 1346614015450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614015451 dimer interface [polypeptide binding]; other site 1346614015452 conserved gate region; other site 1346614015453 putative PBP binding loops; other site 1346614015454 ABC-ATPase subunit interface; other site 1346614015455 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 1346614015456 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1346614015457 Walker A/P-loop; other site 1346614015458 ATP binding site [chemical binding]; other site 1346614015459 Q-loop/lid; other site 1346614015460 ABC transporter signature motif; other site 1346614015461 Walker B; other site 1346614015462 D-loop; other site 1346614015463 H-loop/switch region; other site 1346614015464 transcriptional regulator PhoU; Provisional; Region: PRK11115 1346614015465 PhoU domain; Region: PhoU; pfam01895 1346614015466 PhoU domain; Region: PhoU; pfam01895 1346614015467 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1346614015468 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1346614015469 substrate binding pocket [chemical binding]; other site 1346614015470 membrane-bound complex binding site; other site 1346614015471 hinge residues; other site 1346614015472 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1346614015473 dimer interface [polypeptide binding]; other site 1346614015474 conserved gate region; other site 1346614015475 putative PBP binding loops; other site 1346614015476 ABC-ATPase subunit interface; other site 1346614015477 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 1346614015478 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1346614015479 motif II; other site 1346614015480 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1346614015481 Predicted flavoprotein [General function prediction only]; Region: COG0431 1346614015482 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1346614015483 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1346614015484 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1346614015485 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1346614015486 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1346614015487 RHS protein; Region: RHS; pfam03527 1346614015488 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1346614015489 YaaC-like Protein; Region: YaaC; pfam14175 1346614015490 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1346614015491 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1346614015492 RHS protein; Region: RHS; pfam03527 1346614015493 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1346614015494 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 1346614015495 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1346614015496 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1346614015497 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1346614015498 G1 box; other site 1346614015499 GTP/Mg2+ binding site [chemical binding]; other site 1346614015500 Switch I region; other site 1346614015501 G2 box; other site 1346614015502 Switch II region; other site 1346614015503 G3 box; other site 1346614015504 G4 box; other site 1346614015505 G5 box; other site 1346614015506 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1346614015507 membrane protein insertase; Provisional; Region: PRK01318 1346614015508 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1346614015509 ribonuclease P; Reviewed; Region: rnpA; PRK01732 1346614015510 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1346614015511 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1346614015512 purine monophosphate binding site [chemical binding]; other site 1346614015513 dimer interface [polypeptide binding]; other site 1346614015514 putative catalytic residues [active] 1346614015515 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1346614015516 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1346614015517 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1346614015518 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1346614015519 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1346614015520 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1346614015521 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 1346614015522 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1346614015523 IHF dimer interface [polypeptide binding]; other site 1346614015524 IHF - DNA interface [nucleotide binding]; other site 1346614015525 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 1346614015526 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1346614015527 Active_site [active] 1346614015528 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1346614015529 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1346614015530 substrate binding site [chemical binding]; other site 1346614015531 active site 1346614015532 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1346614015533 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1346614015534 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1346614015535 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1346614015536 putative NADH binding site [chemical binding]; other site 1346614015537 putative active site [active] 1346614015538 nudix motif; other site 1346614015539 putative metal binding site [ion binding]; other site 1346614015540 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 1346614015541 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1346614015542 ThiC-associated domain; Region: ThiC-associated; pfam13667 1346614015543 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1346614015544 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1346614015545 thiamine phosphate binding site [chemical binding]; other site 1346614015546 active site 1346614015547 pyrophosphate binding site [ion binding]; other site 1346614015548 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1346614015549 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1346614015550 ATP binding site [chemical binding]; other site 1346614015551 substrate interface [chemical binding]; other site 1346614015552 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1346614015553 thiS-thiF/thiG interaction site; other site 1346614015554 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1346614015555 ThiS interaction site; other site 1346614015556 putative active site [active] 1346614015557 tetramer interface [polypeptide binding]; other site 1346614015558 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 1346614015559 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1346614015560 FeS/SAM binding site; other site 1346614015561 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1346614015562 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1346614015563 active site 1346614015564 cheY-homologous receiver domain; Region: REC; smart00448 1346614015565 active site 1346614015566 phosphorylation site [posttranslational modification] 1346614015567 intermolecular recognition site; other site 1346614015568 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1346614015569 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1346614015570 ATP binding site [chemical binding]; other site 1346614015571 Mg2+ binding site [ion binding]; other site 1346614015572 G-X-G motif; other site 1346614015573 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1346614015574 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1346614015575 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614015576 Coenzyme A binding pocket [chemical binding]; other site 1346614015577 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1346614015578 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1346614015579 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1346614015580 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1346614015581 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1346614015582 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1346614015583 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1346614015584 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1346614015585 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1346614015586 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1346614015587 DNA binding site [nucleotide binding] 1346614015588 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1346614015589 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1346614015590 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1346614015591 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1346614015592 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1346614015593 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1346614015594 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1346614015595 RPB3 interaction site [polypeptide binding]; other site 1346614015596 RPB1 interaction site [polypeptide binding]; other site 1346614015597 RPB11 interaction site [polypeptide binding]; other site 1346614015598 RPB10 interaction site [polypeptide binding]; other site 1346614015599 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1346614015600 core dimer interface [polypeptide binding]; other site 1346614015601 peripheral dimer interface [polypeptide binding]; other site 1346614015602 L10 interface [polypeptide binding]; other site 1346614015603 L11 interface [polypeptide binding]; other site 1346614015604 putative EF-Tu interaction site [polypeptide binding]; other site 1346614015605 putative EF-G interaction site [polypeptide binding]; other site 1346614015606 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1346614015607 23S rRNA interface [nucleotide binding]; other site 1346614015608 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1346614015609 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1346614015610 mRNA/rRNA interface [nucleotide binding]; other site 1346614015611 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1346614015612 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1346614015613 23S rRNA interface [nucleotide binding]; other site 1346614015614 L7/L12 interface [polypeptide binding]; other site 1346614015615 putative thiostrepton binding site; other site 1346614015616 L25 interface [polypeptide binding]; other site 1346614015617 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1346614015618 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1346614015619 putative homodimer interface [polypeptide binding]; other site 1346614015620 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1346614015621 heterodimer interface [polypeptide binding]; other site 1346614015622 homodimer interface [polypeptide binding]; other site 1346614015623 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1346614015624 elongation factor Tu; Reviewed; Region: PRK00049 1346614015625 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1346614015626 G1 box; other site 1346614015627 GEF interaction site [polypeptide binding]; other site 1346614015628 GTP/Mg2+ binding site [chemical binding]; other site 1346614015629 Switch I region; other site 1346614015630 G2 box; other site 1346614015631 G3 box; other site 1346614015632 Switch II region; other site 1346614015633 G4 box; other site 1346614015634 G5 box; other site 1346614015635 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1346614015636 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1346614015637 Antibiotic Binding Site [chemical binding]; other site 1346614015638 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1346614015639 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1346614015640 Coenzyme A binding pocket [chemical binding]; other site 1346614015641 pantothenate kinase; Provisional; Region: PRK05439 1346614015642 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1346614015643 ATP-binding site [chemical binding]; other site 1346614015644 CoA-binding site [chemical binding]; other site 1346614015645 Mg2+-binding site [ion binding]; other site 1346614015646 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1346614015647 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1346614015648 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1346614015649 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1346614015650 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1346614015651 FAD binding domain; Region: FAD_binding_4; pfam01565 1346614015652 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873