-- dump date 20140620_062741 -- class Genbank::misc_feature -- table misc_feature_note -- id note 768492000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 768492000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 768492000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492000004 Walker A motif; other site 768492000005 ATP binding site [chemical binding]; other site 768492000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 768492000007 Walker B motif; other site 768492000008 arginine finger; other site 768492000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 768492000010 DnaA box-binding interface [nucleotide binding]; other site 768492000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 768492000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 768492000013 putative DNA binding surface [nucleotide binding]; other site 768492000014 dimer interface [polypeptide binding]; other site 768492000015 beta-clamp/clamp loader binding surface; other site 768492000016 beta-clamp/translesion DNA polymerase binding surface; other site 768492000017 recF protein; Region: recf; TIGR00611 768492000018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768492000019 Walker A/P-loop; other site 768492000020 ATP binding site [chemical binding]; other site 768492000021 Q-loop/lid; other site 768492000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768492000023 ABC transporter signature motif; other site 768492000024 Walker B; other site 768492000025 D-loop; other site 768492000026 H-loop/switch region; other site 768492000027 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 768492000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492000029 Mg2+ binding site [ion binding]; other site 768492000030 G-X-G motif; other site 768492000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 768492000032 anchoring element; other site 768492000033 dimer interface [polypeptide binding]; other site 768492000034 ATP binding site [chemical binding]; other site 768492000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 768492000036 active site 768492000037 putative metal-binding site [ion binding]; other site 768492000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 768492000039 sugar phosphate phosphatase; Provisional; Region: PRK10513 768492000040 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492000041 active site 768492000042 motif I; other site 768492000043 motif II; other site 768492000044 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492000045 motif I; other site 768492000046 active site 768492000047 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 768492000048 ornithine cyclodeaminase; Validated; Region: PRK06823 768492000049 hypothetical protein; Provisional; Region: PRK06815 768492000050 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 768492000051 tetramer interface [polypeptide binding]; other site 768492000052 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492000053 catalytic residue [active] 768492000054 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 768492000055 hypothetical protein; Provisional; Region: PRK11616 768492000056 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 768492000057 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 768492000058 putative dimer interface [polypeptide binding]; other site 768492000059 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 768492000060 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 768492000061 putative dimer interface [polypeptide binding]; other site 768492000062 putative transporter; Validated; Region: PRK03818 768492000063 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 768492000064 TrkA-C domain; Region: TrkA_C; pfam02080 768492000065 TrkA-C domain; Region: TrkA_C; pfam02080 768492000066 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 768492000067 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 768492000068 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492000069 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492000070 homodimer interface [polypeptide binding]; other site 768492000071 catalytic residue [active] 768492000072 alpha-amylase; Reviewed; Region: malS; PRK09505 768492000073 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 768492000074 active site 768492000075 catalytic site [active] 768492000076 Predicted transcriptional regulator [Transcription]; Region: COG3905 768492000077 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 768492000078 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 768492000079 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 768492000080 dimerization interface [polypeptide binding]; other site 768492000081 ligand binding site [chemical binding]; other site 768492000082 NADP binding site [chemical binding]; other site 768492000083 catalytic site [active] 768492000084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492000085 D-galactonate transporter; Region: 2A0114; TIGR00893 768492000086 putative substrate translocation pore; other site 768492000087 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768492000088 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 768492000089 substrate binding site [chemical binding]; other site 768492000090 ATP binding site [chemical binding]; other site 768492000091 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 768492000092 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768492000093 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492000094 DNA binding site [nucleotide binding] 768492000095 domain linker motif; other site 768492000096 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 768492000097 putative dimerization interface [polypeptide binding]; other site 768492000098 putative ligand binding site [chemical binding]; other site 768492000099 putative outer membrane lipoprotein; Provisional; Region: PRK10510 768492000100 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 768492000101 ligand binding site [chemical binding]; other site 768492000102 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768492000103 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492000104 Coenzyme A binding pocket [chemical binding]; other site 768492000105 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 768492000106 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 768492000107 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 768492000108 active site 768492000109 catalytic triad [active] 768492000110 oxyanion hole [active] 768492000111 Autotransporter beta-domain; Region: Autotransporter; cl17461 768492000112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492000113 D-galactonate transporter; Region: 2A0114; TIGR00893 768492000114 putative substrate translocation pore; other site 768492000115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492000116 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 768492000117 dimer interface [polypeptide binding]; other site 768492000118 motif 1; other site 768492000119 active site 768492000120 motif 2; other site 768492000121 motif 3; other site 768492000122 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 768492000123 DALR anticodon binding domain; Region: DALR_1; pfam05746 768492000124 Fic family protein [Function unknown]; Region: COG3177 768492000125 Fic/DOC family; Region: Fic; pfam02661 768492000126 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 768492000127 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 768492000128 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 768492000129 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 768492000130 active site 768492000131 P-loop; other site 768492000132 phosphorylation site [posttranslational modification] 768492000133 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 768492000134 active site 768492000135 phosphorylation site [posttranslational modification] 768492000136 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 768492000137 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 768492000138 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 768492000139 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 768492000140 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 768492000141 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 768492000142 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768492000143 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492000144 DNA-binding site [nucleotide binding]; DNA binding site 768492000145 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492000146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492000147 homodimer interface [polypeptide binding]; other site 768492000148 catalytic residue [active] 768492000149 hypothetical protein; Provisional; Region: PRK11020 768492000150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492000151 S-adenosylmethionine binding site [chemical binding]; other site 768492000152 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 768492000153 MOSC domain; Region: MOSC; pfam03473 768492000154 3-alpha domain; Region: 3-alpha; pfam03475 768492000155 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768492000156 dimerization interface [polypeptide binding]; other site 768492000157 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 768492000158 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768492000159 dimer interface [polypeptide binding]; other site 768492000160 putative CheW interface [polypeptide binding]; other site 768492000161 superoxide dismutase; Provisional; Region: PRK10925 768492000162 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 768492000163 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 768492000164 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 768492000165 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 768492000166 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 768492000167 [4Fe-4S] binding site [ion binding]; other site 768492000168 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 768492000169 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 768492000170 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 768492000171 molybdopterin cofactor binding site; other site 768492000172 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 768492000173 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 768492000174 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 768492000175 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 768492000176 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 768492000177 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 768492000178 hypothetical protein; Provisional; Region: PRK11615 768492000179 putative glutathione S-transferase; Provisional; Region: PRK10357 768492000180 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 768492000181 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 768492000182 dimer interface [polypeptide binding]; other site 768492000183 N-terminal domain interface [polypeptide binding]; other site 768492000184 putative substrate binding pocket (H-site) [chemical binding]; other site 768492000185 selenocysteine synthase; Provisional; Region: PRK04311 768492000186 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 768492000187 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 768492000188 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492000189 catalytic residue [active] 768492000190 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 768492000191 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 768492000192 G1 box; other site 768492000193 putative GEF interaction site [polypeptide binding]; other site 768492000194 GTP/Mg2+ binding site [chemical binding]; other site 768492000195 Switch I region; other site 768492000196 G2 box; other site 768492000197 G3 box; other site 768492000198 Switch II region; other site 768492000199 G4 box; other site 768492000200 G5 box; other site 768492000201 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 768492000202 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 768492000203 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 768492000204 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 768492000205 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 768492000206 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 768492000207 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 768492000208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492000209 putative substrate translocation pore; other site 768492000210 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 768492000211 Acyltransferase family; Region: Acyl_transf_3; pfam01757 768492000212 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 768492000213 conserved cys residue [active] 768492000214 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492000215 Isochorismatase family; Region: Isochorismatase; pfam00857 768492000216 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 768492000217 catalytic triad [active] 768492000218 conserved cis-peptide bond; other site 768492000219 putative deaminase; Validated; Region: PRK06846 768492000220 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 768492000221 active site 768492000222 xylulokinase; Provisional; Region: PRK15027 768492000223 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 768492000224 N- and C-terminal domain interface [polypeptide binding]; other site 768492000225 active site 768492000226 MgATP binding site [chemical binding]; other site 768492000227 catalytic site [active] 768492000228 metal binding site [ion binding]; metal-binding site 768492000229 xylulose binding site [chemical binding]; other site 768492000230 homodimer interface [polypeptide binding]; other site 768492000231 xylose isomerase; Provisional; Region: PRK05474 768492000232 xylose isomerase; Region: xylose_isom_A; TIGR02630 768492000233 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 768492000234 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 768492000235 putative ligand binding site [chemical binding]; other site 768492000236 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 768492000237 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768492000238 Walker A/P-loop; other site 768492000239 ATP binding site [chemical binding]; other site 768492000240 Q-loop/lid; other site 768492000241 ABC transporter signature motif; other site 768492000242 Walker B; other site 768492000243 D-loop; other site 768492000244 H-loop/switch region; other site 768492000245 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768492000246 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 768492000247 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768492000248 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768492000249 TM-ABC transporter signature motif; other site 768492000250 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 768492000251 putative dimerization interface [polypeptide binding]; other site 768492000252 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768492000253 putative ligand binding site [chemical binding]; other site 768492000254 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492000255 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768492000256 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492000257 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492000258 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492000259 dimerization interface [polypeptide binding]; other site 768492000260 putative cyanate transporter; Provisional; Region: cynX; PRK09705 768492000261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492000262 putative substrate translocation pore; other site 768492000263 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 768492000264 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 768492000265 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 768492000266 active site 768492000267 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 768492000268 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 768492000269 putative active site [active] 768492000270 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768492000271 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 768492000272 Walker A/P-loop; other site 768492000273 ATP binding site [chemical binding]; other site 768492000274 Q-loop/lid; other site 768492000275 ABC transporter signature motif; other site 768492000276 Walker B; other site 768492000277 D-loop; other site 768492000278 H-loop/switch region; other site 768492000279 HlyD family secretion protein; Region: HlyD; pfam00529 768492000280 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768492000281 HlyD family secretion protein; Region: HlyD_3; pfam13437 768492000282 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 768492000283 active site 768492000284 NTP binding site [chemical binding]; other site 768492000285 metal binding triad [ion binding]; metal-binding site 768492000286 Autoinducer binding domain; Region: Autoind_bind; pfam03472 768492000287 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492000288 DNA binding residues [nucleotide binding] 768492000289 dimerization interface [polypeptide binding]; other site 768492000290 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 768492000291 catalytic core [active] 768492000292 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 768492000293 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768492000294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492000295 putative substrate translocation pore; other site 768492000296 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492000297 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492000298 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492000299 putative effector binding pocket; other site 768492000300 dimerization interface [polypeptide binding]; other site 768492000301 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 768492000302 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768492000303 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492000304 NAD(P) binding site [chemical binding]; other site 768492000305 active site 768492000306 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492000307 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492000308 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768492000309 dimerization interface [polypeptide binding]; other site 768492000310 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 768492000311 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492000312 NAD(P) binding site [chemical binding]; other site 768492000313 active site 768492000314 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 768492000315 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768492000316 active site turn [active] 768492000317 phosphorylation site [posttranslational modification] 768492000318 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768492000319 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 768492000320 HPr interaction site; other site 768492000321 glycerol kinase (GK) interaction site [polypeptide binding]; other site 768492000322 active site 768492000323 phosphorylation site [posttranslational modification] 768492000324 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 768492000325 beta-galactosidase; Region: BGL; TIGR03356 768492000326 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 768492000327 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 768492000328 HD domain; Region: HD_4; pfam13328 768492000329 Transcriptional regulators [Transcription]; Region: MarR; COG1846 768492000330 MarR family; Region: MarR; pfam01047 768492000331 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 768492000332 phosphoethanolamine transferase; Provisional; Region: PRK11560 768492000333 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 768492000334 Sulfatase; Region: Sulfatase; pfam00884 768492000335 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 768492000336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492000337 active site 768492000338 phosphorylation site [posttranslational modification] 768492000339 intermolecular recognition site; other site 768492000340 dimerization interface [polypeptide binding]; other site 768492000341 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492000342 DNA binding residues [nucleotide binding] 768492000343 dimerization interface [polypeptide binding]; other site 768492000344 sensory histidine kinase UhpB; Provisional; Region: PRK11644 768492000345 MASE1; Region: MASE1; cl17823 768492000346 MASE1; Region: MASE1; cl17823 768492000347 Histidine kinase; Region: HisKA_3; pfam07730 768492000348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492000349 ATP binding site [chemical binding]; other site 768492000350 Mg2+ binding site [ion binding]; other site 768492000351 G-X-G motif; other site 768492000352 regulatory protein UhpC; Provisional; Region: PRK11663 768492000353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492000354 putative substrate translocation pore; other site 768492000355 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492000356 Predicted transcriptional regulator [Transcription]; Region: COG4190 768492000357 N-terminal Early set domain associated with the catalytic domain of chitinase; Region: E_set_Chitinase_N; cd02848 768492000358 Glyco_18 domain; Region: Glyco_18; smart00636 768492000359 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 768492000360 active site 768492000361 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 768492000362 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 768492000363 peptide binding site [polypeptide binding]; other site 768492000364 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 768492000365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492000366 dimer interface [polypeptide binding]; other site 768492000367 conserved gate region; other site 768492000368 putative PBP binding loops; other site 768492000369 ABC-ATPase subunit interface; other site 768492000370 dipeptide transporter; Provisional; Region: PRK10913 768492000371 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 768492000372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492000373 dimer interface [polypeptide binding]; other site 768492000374 conserved gate region; other site 768492000375 putative PBP binding loops; other site 768492000376 ABC-ATPase subunit interface; other site 768492000377 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 768492000378 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768492000379 Walker A/P-loop; other site 768492000380 ATP binding site [chemical binding]; other site 768492000381 Q-loop/lid; other site 768492000382 ABC transporter signature motif; other site 768492000383 Walker B; other site 768492000384 D-loop; other site 768492000385 H-loop/switch region; other site 768492000386 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768492000387 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 768492000388 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768492000389 Walker A/P-loop; other site 768492000390 ATP binding site [chemical binding]; other site 768492000391 Q-loop/lid; other site 768492000392 ABC transporter signature motif; other site 768492000393 Walker B; other site 768492000394 D-loop; other site 768492000395 H-loop/switch region; other site 768492000396 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 768492000397 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 768492000398 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 768492000399 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 768492000400 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 768492000401 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 768492000402 YhjQ protein; Region: YhjQ; pfam06564 768492000403 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 768492000404 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 768492000405 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 768492000406 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 768492000407 DXD motif; other site 768492000408 PilZ domain; Region: PilZ; pfam07238 768492000409 cellulose synthase regulator protein; Provisional; Region: PRK11114 768492000410 endo-1,4-D-glucanase; Provisional; Region: PRK11097 768492000411 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 768492000412 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768492000413 TPR motif; other site 768492000414 binding surface 768492000415 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768492000416 binding surface 768492000417 TPR motif; other site 768492000418 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768492000419 binding surface 768492000420 TPR motif; other site 768492000421 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 768492000422 putative diguanylate cyclase; Provisional; Region: PRK13561 768492000423 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768492000424 metal binding site [ion binding]; metal-binding site 768492000425 active site 768492000426 I-site; other site 768492000427 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768492000428 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 768492000429 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 768492000430 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 768492000431 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 768492000432 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 768492000433 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 768492000434 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 768492000435 Part of AAA domain; Region: AAA_19; pfam13245 768492000436 Family description; Region: UvrD_C_2; pfam13538 768492000437 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 768492000438 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 768492000439 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 768492000440 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 768492000441 ATP binding site [chemical binding]; other site 768492000442 Mg++ binding site [ion binding]; other site 768492000443 motif III; other site 768492000444 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768492000445 nucleotide binding region [chemical binding]; other site 768492000446 ATP-binding site [chemical binding]; other site 768492000447 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 768492000448 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 768492000449 catalytic residues [active] 768492000450 transcription termination factor Rho; Provisional; Region: rho; PRK09376 768492000451 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 768492000452 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 768492000453 RNA binding site [nucleotide binding]; other site 768492000454 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 768492000455 multimer interface [polypeptide binding]; other site 768492000456 Walker A motif; other site 768492000457 ATP binding site [chemical binding]; other site 768492000458 Walker B motif; other site 768492000459 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 768492000460 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 768492000461 Mg++ binding site [ion binding]; other site 768492000462 putative catalytic motif [active] 768492000463 substrate binding site [chemical binding]; other site 768492000464 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 768492000465 Chain length determinant protein; Region: Wzz; cl15801 768492000466 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 768492000467 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 768492000468 active site 768492000469 homodimer interface [polypeptide binding]; other site 768492000470 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 768492000471 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 768492000472 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 768492000473 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 768492000474 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 768492000475 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 768492000476 NAD binding site [chemical binding]; other site 768492000477 substrate binding site [chemical binding]; other site 768492000478 homodimer interface [polypeptide binding]; other site 768492000479 active site 768492000480 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 768492000481 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 768492000482 substrate binding site; other site 768492000483 tetramer interface; other site 768492000484 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768492000485 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492000486 Coenzyme A binding pocket [chemical binding]; other site 768492000487 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 768492000488 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 768492000489 inhibitor-cofactor binding pocket; inhibition site 768492000490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492000491 catalytic residue [active] 768492000492 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 768492000493 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 768492000494 putative common antigen polymerase; Provisional; Region: PRK02975 768492000495 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 768492000496 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 768492000497 putative transport protein YifK; Provisional; Region: PRK10746 768492000498 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 768492000499 HemY protein N-terminus; Region: HemY_N; pfam07219 768492000500 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 768492000501 TPR motif; other site 768492000502 binding surface 768492000503 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 768492000504 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 768492000505 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 768492000506 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 768492000507 active site 768492000508 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 768492000509 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 768492000510 domain interfaces; other site 768492000511 active site 768492000512 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 768492000513 adenylate cyclase; Provisional; Region: cyaA; PRK09450 768492000514 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 768492000515 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 768492000516 putative iron binding site [ion binding]; other site 768492000517 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 768492000518 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 768492000519 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 768492000520 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 768492000521 hypothetical protein; Provisional; Region: PRK10963 768492000522 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 768492000523 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768492000524 active site 768492000525 DNA binding site [nucleotide binding] 768492000526 Int/Topo IB signature motif; other site 768492000527 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 768492000528 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492000529 motif II; other site 768492000530 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 768492000531 Part of AAA domain; Region: AAA_19; pfam13245 768492000532 Family description; Region: UvrD_C_2; pfam13538 768492000533 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 768492000534 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 768492000535 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 768492000536 oligomer interface [polypeptide binding]; other site 768492000537 Cl binding site [ion binding]; other site 768492000538 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 768492000539 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 768492000540 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 768492000541 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 768492000542 EamA-like transporter family; Region: EamA; cl17759 768492000543 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 768492000544 CoenzymeA binding site [chemical binding]; other site 768492000545 subunit interaction site [polypeptide binding]; other site 768492000546 PHB binding site; other site 768492000547 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 768492000548 dimerization interface [polypeptide binding]; other site 768492000549 substrate binding site [chemical binding]; other site 768492000550 active site 768492000551 calcium binding site [ion binding]; other site 768492000552 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 768492000553 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768492000554 ATP binding site [chemical binding]; other site 768492000555 putative Mg++ binding site [ion binding]; other site 768492000556 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768492000557 nucleotide binding region [chemical binding]; other site 768492000558 ATP-binding site [chemical binding]; other site 768492000559 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 768492000560 HRDC domain; Region: HRDC; pfam00570 768492000561 threonine efflux system; Provisional; Region: PRK10229 768492000562 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 768492000563 lysophospholipase L2; Provisional; Region: PRK10749 768492000564 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 768492000565 putative hydrolase; Provisional; Region: PRK10976 768492000566 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492000567 active site 768492000568 motif I; other site 768492000569 motif II; other site 768492000570 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492000571 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 768492000572 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 768492000573 active site 768492000574 catalytic site [active] 768492000575 metal binding site [ion binding]; metal-binding site 768492000576 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 768492000577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492000578 putative substrate translocation pore; other site 768492000579 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 768492000580 hydroxyglutarate oxidase; Provisional; Region: PRK11728 768492000581 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 768492000582 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 768492000583 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 768492000584 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 768492000585 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768492000586 Cysteine-rich domain; Region: CCG; pfam02754 768492000587 Cysteine-rich domain; Region: CCG; pfam02754 768492000588 hypothetical protein; Provisional; Region: PRK11615 768492000589 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492000590 Coenzyme A binding pocket [chemical binding]; other site 768492000591 hypothetical protein; Provisional; Region: PRK11212 768492000592 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 768492000593 CPxP motif; other site 768492000594 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 768492000595 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 768492000596 metal-binding site [ion binding] 768492000597 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768492000598 Soluble P-type ATPase [General function prediction only]; Region: COG4087 768492000599 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 768492000600 active site 768492000601 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 768492000602 Protease inhibitor Inh; Region: Inh; pfam02974 768492000603 Predicted membrane protein [Function unknown]; Region: COG3714 768492000604 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 768492000605 hypothetical protein; Provisional; Region: PRK10910 768492000606 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 768492000607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492000608 S-adenosylmethionine binding site [chemical binding]; other site 768492000609 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 768492000610 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 768492000611 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 768492000612 P loop; other site 768492000613 GTP binding site [chemical binding]; other site 768492000614 cell division protein FtsE; Provisional; Region: PRK10908 768492000615 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768492000616 Walker A/P-loop; other site 768492000617 ATP binding site [chemical binding]; other site 768492000618 Q-loop/lid; other site 768492000619 ABC transporter signature motif; other site 768492000620 Walker B; other site 768492000621 D-loop; other site 768492000622 H-loop/switch region; other site 768492000623 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 768492000624 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 768492000625 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 768492000626 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768492000627 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768492000628 DNA binding residues [nucleotide binding] 768492000629 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 768492000630 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 768492000631 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 768492000632 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 768492000633 dimerization interface [polypeptide binding]; other site 768492000634 ligand binding site [chemical binding]; other site 768492000635 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768492000636 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 768492000637 TM-ABC transporter signature motif; other site 768492000638 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 768492000639 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 768492000640 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 768492000641 TM-ABC transporter signature motif; other site 768492000642 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 768492000643 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 768492000644 Walker A/P-loop; other site 768492000645 ATP binding site [chemical binding]; other site 768492000646 Q-loop/lid; other site 768492000647 ABC transporter signature motif; other site 768492000648 Walker B; other site 768492000649 D-loop; other site 768492000650 H-loop/switch region; other site 768492000651 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 768492000652 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 768492000653 Walker A/P-loop; other site 768492000654 ATP binding site [chemical binding]; other site 768492000655 Q-loop/lid; other site 768492000656 ABC transporter signature motif; other site 768492000657 Walker B; other site 768492000658 D-loop; other site 768492000659 H-loop/switch region; other site 768492000660 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 768492000661 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492000662 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492000663 homodimer interface [polypeptide binding]; other site 768492000664 catalytic residue [active] 768492000665 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 768492000666 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 768492000667 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 768492000668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492000669 dimer interface [polypeptide binding]; other site 768492000670 conserved gate region; other site 768492000671 putative PBP binding loops; other site 768492000672 ABC-ATPase subunit interface; other site 768492000673 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 768492000674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492000675 dimer interface [polypeptide binding]; other site 768492000676 conserved gate region; other site 768492000677 putative PBP binding loops; other site 768492000678 ABC-ATPase subunit interface; other site 768492000679 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 768492000680 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 768492000681 Walker A/P-loop; other site 768492000682 ATP binding site [chemical binding]; other site 768492000683 Q-loop/lid; other site 768492000684 ABC transporter signature motif; other site 768492000685 Walker B; other site 768492000686 D-loop; other site 768492000687 H-loop/switch region; other site 768492000688 TOBE domain; Region: TOBE_2; pfam08402 768492000689 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 768492000690 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 768492000691 putative active site [active] 768492000692 catalytic site [active] 768492000693 putative metal binding site [ion binding]; other site 768492000694 Predicted permeases [General function prediction only]; Region: COG0679 768492000695 EamA-like transporter family; Region: EamA; pfam00892 768492000696 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 768492000697 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 768492000698 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492000699 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 768492000700 putative dimerization interface [polypeptide binding]; other site 768492000701 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 768492000702 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 768492000703 THF binding site; other site 768492000704 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 768492000705 substrate binding site [chemical binding]; other site 768492000706 THF binding site; other site 768492000707 zinc-binding site [ion binding]; other site 768492000708 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 768492000709 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 768492000710 uridine phosphorylase; Provisional; Region: PRK11178 768492000711 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 768492000712 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 768492000713 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 768492000714 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 768492000715 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 768492000716 DNA recombination protein RmuC; Provisional; Region: PRK10361 768492000717 RmuC family; Region: RmuC; pfam02646 768492000718 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 768492000719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492000720 S-adenosylmethionine binding site [chemical binding]; other site 768492000721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 768492000722 SCP-2 sterol transfer family; Region: SCP2; pfam02036 768492000723 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 768492000724 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 768492000725 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 768492000726 sec-independent translocase; Provisional; Region: PRK01770 768492000727 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 768492000728 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 768492000729 active site 768492000730 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 768492000731 dimer interface [polypeptide binding]; other site 768492000732 active site 768492000733 aspartate-rich active site metal binding site; other site 768492000734 allosteric magnesium binding site [ion binding]; other site 768492000735 Schiff base residues; other site 768492000736 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 768492000737 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 768492000738 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 768492000739 active site pocket [active] 768492000740 oxyanion hole [active] 768492000741 catalytic triad [active] 768492000742 active site nucleophile [active] 768492000743 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 768492000744 FMN reductase; Validated; Region: fre; PRK08051 768492000745 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 768492000746 FAD binding pocket [chemical binding]; other site 768492000747 FAD binding motif [chemical binding]; other site 768492000748 phosphate binding motif [ion binding]; other site 768492000749 beta-alpha-beta structure motif; other site 768492000750 NAD binding pocket [chemical binding]; other site 768492000751 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 768492000752 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 768492000753 dimer interface [polypeptide binding]; other site 768492000754 active site 768492000755 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 768492000756 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768492000757 substrate binding site [chemical binding]; other site 768492000758 oxyanion hole (OAH) forming residues; other site 768492000759 trimer interface [polypeptide binding]; other site 768492000760 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 768492000761 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768492000762 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768492000763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492000764 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768492000765 putative substrate translocation pore; other site 768492000766 proline dipeptidase; Provisional; Region: PRK13607 768492000767 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 768492000768 active site 768492000769 hypothetical protein; Provisional; Region: PRK11568 768492000770 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 768492000771 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 768492000772 potassium transporter; Provisional; Region: PRK10750 768492000773 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 768492000774 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 768492000775 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 768492000776 FAD binding domain; Region: FAD_binding_4; pfam01565 768492000777 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 768492000778 Biotin operon repressor [Transcription]; Region: BirA; COG1654 768492000779 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 768492000780 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 768492000781 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 768492000782 pantothenate kinase; Provisional; Region: PRK05439 768492000783 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 768492000784 ATP-binding site [chemical binding]; other site 768492000785 CoA-binding site [chemical binding]; other site 768492000786 Mg2+-binding site [ion binding]; other site 768492000787 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768492000788 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492000789 Coenzyme A binding pocket [chemical binding]; other site 768492000790 elongation factor Tu; Reviewed; Region: PRK00049 768492000791 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 768492000792 G1 box; other site 768492000793 GEF interaction site [polypeptide binding]; other site 768492000794 GTP/Mg2+ binding site [chemical binding]; other site 768492000795 Switch I region; other site 768492000796 G2 box; other site 768492000797 G3 box; other site 768492000798 Switch II region; other site 768492000799 G4 box; other site 768492000800 G5 box; other site 768492000801 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 768492000802 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 768492000803 Antibiotic Binding Site [chemical binding]; other site 768492000804 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 768492000805 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 768492000806 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 768492000807 putative homodimer interface [polypeptide binding]; other site 768492000808 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 768492000809 heterodimer interface [polypeptide binding]; other site 768492000810 homodimer interface [polypeptide binding]; other site 768492000811 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 768492000812 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 768492000813 23S rRNA interface [nucleotide binding]; other site 768492000814 L7/L12 interface [polypeptide binding]; other site 768492000815 putative thiostrepton binding site; other site 768492000816 L25 interface [polypeptide binding]; other site 768492000817 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 768492000818 mRNA/rRNA interface [nucleotide binding]; other site 768492000819 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 768492000820 23S rRNA interface [nucleotide binding]; other site 768492000821 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 768492000822 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 768492000823 core dimer interface [polypeptide binding]; other site 768492000824 peripheral dimer interface [polypeptide binding]; other site 768492000825 L10 interface [polypeptide binding]; other site 768492000826 L11 interface [polypeptide binding]; other site 768492000827 putative EF-Tu interaction site [polypeptide binding]; other site 768492000828 putative EF-G interaction site [polypeptide binding]; other site 768492000829 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 768492000830 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 768492000831 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 768492000832 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 768492000833 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 768492000834 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 768492000835 RPB3 interaction site [polypeptide binding]; other site 768492000836 RPB1 interaction site [polypeptide binding]; other site 768492000837 RPB11 interaction site [polypeptide binding]; other site 768492000838 RPB10 interaction site [polypeptide binding]; other site 768492000839 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 768492000840 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 768492000841 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 768492000842 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 768492000843 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 768492000844 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 768492000845 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 768492000846 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 768492000847 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 768492000848 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 768492000849 DNA binding site [nucleotide binding] 768492000850 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 768492000851 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768492000852 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492000853 Coenzyme A binding pocket [chemical binding]; other site 768492000854 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 768492000855 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768492000856 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492000857 ATP binding site [chemical binding]; other site 768492000858 Mg2+ binding site [ion binding]; other site 768492000859 G-X-G motif; other site 768492000860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 768492000861 active site 768492000862 phosphorylation site [posttranslational modification] 768492000863 intermolecular recognition site; other site 768492000864 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 768492000865 active site 768492000866 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 768492000867 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768492000868 FeS/SAM binding site; other site 768492000869 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 768492000870 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 768492000871 ThiS interaction site; other site 768492000872 putative active site [active] 768492000873 tetramer interface [polypeptide binding]; other site 768492000874 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 768492000875 thiS-thiF/thiG interaction site; other site 768492000876 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 768492000877 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 768492000878 ATP binding site [chemical binding]; other site 768492000879 substrate interface [chemical binding]; other site 768492000880 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 768492000881 thiamine phosphate binding site [chemical binding]; other site 768492000882 active site 768492000883 pyrophosphate binding site [ion binding]; other site 768492000884 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 768492000885 ThiC-associated domain; Region: ThiC-associated; pfam13667 768492000886 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 768492000887 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 768492000888 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 768492000889 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 768492000890 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 768492000891 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 768492000892 putative NADH binding site [chemical binding]; other site 768492000893 putative active site [active] 768492000894 nudix motif; other site 768492000895 putative metal binding site [ion binding]; other site 768492000896 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 768492000897 substrate binding site [chemical binding]; other site 768492000898 active site 768492000899 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 768492000900 Active_site [active] 768492000901 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 768492000902 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 768492000903 IHF dimer interface [polypeptide binding]; other site 768492000904 IHF - DNA interface [nucleotide binding]; other site 768492000905 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 768492000906 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 768492000907 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 768492000908 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 768492000909 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 768492000910 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 768492000911 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 768492000912 purine monophosphate binding site [chemical binding]; other site 768492000913 dimer interface [polypeptide binding]; other site 768492000914 putative catalytic residues [active] 768492000915 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 768492000916 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 768492000917 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 768492000918 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 768492000919 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 768492000920 Na binding site [ion binding]; other site 768492000921 Predicted membrane protein [Function unknown]; Region: COG3162 768492000922 acetyl-CoA synthetase; Provisional; Region: PRK00174 768492000923 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 768492000924 active site 768492000925 CoA binding site [chemical binding]; other site 768492000926 acyl-activating enzyme (AAE) consensus motif; other site 768492000927 AMP binding site [chemical binding]; other site 768492000928 acetate binding site [chemical binding]; other site 768492000929 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 768492000930 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 768492000931 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 768492000932 active site clefts [active] 768492000933 zinc binding site [ion binding]; other site 768492000934 dimer interface [polypeptide binding]; other site 768492000935 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 768492000936 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 768492000937 Sulfate transporter family; Region: Sulfate_transp; pfam00916 768492000938 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 768492000939 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 768492000940 P-loop; other site 768492000941 Magnesium ion binding site [ion binding]; other site 768492000942 replicative DNA helicase; Region: DnaB; TIGR00665 768492000943 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 768492000944 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 768492000945 Walker A motif; other site 768492000946 ATP binding site [chemical binding]; other site 768492000947 Walker B motif; other site 768492000948 DNA binding loops [nucleotide binding] 768492000949 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 768492000950 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 768492000951 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 768492000952 Helix-turn-helix domain; Region: HTH_36; pfam13730 768492000953 Domain of unknown function (DUF1845); Region: DUF1845; pfam08900 768492000954 DNA topoisomerase III; Provisional; Region: PRK07726 768492000955 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 768492000956 active site 768492000957 putative interdomain interaction site [polypeptide binding]; other site 768492000958 putative metal-binding site [ion binding]; other site 768492000959 putative nucleotide binding site [chemical binding]; other site 768492000960 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 768492000961 domain I; other site 768492000962 DNA binding groove [nucleotide binding] 768492000963 phosphate binding site [ion binding]; other site 768492000964 domain II; other site 768492000965 domain III; other site 768492000966 nucleotide binding site [chemical binding]; other site 768492000967 catalytic site [active] 768492000968 domain IV; other site 768492000969 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 768492000970 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 768492000971 active site 768492000972 iron coordination sites [ion binding]; other site 768492000973 substrate binding pocket [chemical binding]; other site 768492000974 Domain of unknown function (DUF955); Region: DUF955; pfam06114 768492000975 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 768492000976 Part of AAA domain; Region: AAA_19; pfam13245 768492000977 Family description; Region: UvrD_C_2; pfam13538 768492000978 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 768492000979 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 768492000980 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768492000981 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768492000982 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 768492000983 Restriction endonuclease; Region: Mrr_cat; pfam04471 768492000984 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 768492000985 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 768492000986 integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747 768492000987 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 768492000988 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 768492000989 Protein of unknown function (DUF3262); Region: DUF3262; pfam11660 768492000990 Protein of unknown function (DUF2976); Region: DUF2976; cl12739 768492000991 Protein of unknown function (DUF3487); Region: DUF3487; pfam11990 768492000992 Protein of unknown function (DUF2895); Region: DUF2895; pfam11444 768492000993 Protein of unknown function (DUF3438); Region: DUF3438; pfam11920 768492000994 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 768492000995 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 768492000996 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 768492000997 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 768492000998 Protein of unknown function (DUF1525); Region: DUF1525; pfam07511 768492000999 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 768492001000 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 768492001001 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 768492001002 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768492001003 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768492001004 Walker A/P-loop; other site 768492001005 ATP binding site [chemical binding]; other site 768492001006 RES domain; Region: RES; smart00953 768492001007 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 768492001008 Integrase; Region: Integrase_1; pfam12835 768492001009 Protein of unknown function (DUF3085); Region: DUF3085; pfam11284 768492001010 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 768492001011 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 768492001012 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 768492001013 HlyD family secretion protein; Region: HlyD; pfam00529 768492001014 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768492001015 HlyD family secretion protein; Region: HlyD_3; pfam13437 768492001016 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 768492001017 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 768492001018 putative active site [active] 768492001019 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768492001020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768492001021 Walker A/P-loop; other site 768492001022 ATP binding site [chemical binding]; other site 768492001023 Q-loop/lid; other site 768492001024 ABC transporter signature motif; other site 768492001025 Walker B; other site 768492001026 D-loop; other site 768492001027 H-loop/switch region; other site 768492001028 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768492001029 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492001030 dimer interface [polypeptide binding]; other site 768492001031 phosphorylation site [posttranslational modification] 768492001032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492001033 ATP binding site [chemical binding]; other site 768492001034 Mg2+ binding site [ion binding]; other site 768492001035 G-X-G motif; other site 768492001036 Response regulator receiver domain; Region: Response_reg; pfam00072 768492001037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492001038 active site 768492001039 phosphorylation site [posttranslational modification] 768492001040 intermolecular recognition site; other site 768492001041 dimerization interface [polypeptide binding]; other site 768492001042 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 768492001043 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 768492001044 BetR domain; Region: BetR; pfam08667 768492001045 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 768492001046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492001047 active site 768492001048 phosphorylation site [posttranslational modification] 768492001049 intermolecular recognition site; other site 768492001050 dimerization interface [polypeptide binding]; other site 768492001051 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 768492001052 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 768492001053 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 768492001054 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 768492001055 active site 768492001056 catalytic residues [active] 768492001057 DNA binding site [nucleotide binding] 768492001058 Int/Topo IB signature motif; other site 768492001059 putative transcriptional regulator; Provisional; Region: PRK11640 768492001060 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768492001061 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 768492001062 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 768492001063 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 768492001064 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 768492001065 DsbD alpha interface [polypeptide binding]; other site 768492001066 catalytic residues [active] 768492001067 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 768492001068 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 768492001069 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 768492001070 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 768492001071 Aspartase; Region: Aspartase; cd01357 768492001072 active sites [active] 768492001073 tetramer interface [polypeptide binding]; other site 768492001074 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 768492001075 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 768492001076 oligomerisation interface [polypeptide binding]; other site 768492001077 mobile loop; other site 768492001078 roof hairpin; other site 768492001079 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 768492001080 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 768492001081 ring oligomerisation interface [polypeptide binding]; other site 768492001082 ATP/Mg binding site [chemical binding]; other site 768492001083 stacking interactions; other site 768492001084 hinge regions; other site 768492001085 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 768492001086 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 768492001087 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768492001088 FeS/SAM binding site; other site 768492001089 elongation factor P; Validated; Region: PRK00529 768492001090 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 768492001091 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 768492001092 RNA binding site [nucleotide binding]; other site 768492001093 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 768492001094 RNA binding site [nucleotide binding]; other site 768492001095 entericidin A; Provisional; Region: PRK09810 768492001096 Predicted small secreted protein [Function unknown]; Region: COG5510 768492001097 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 768492001098 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 768492001099 Iron-sulfur protein interface; other site 768492001100 proximal quinone binding site [chemical binding]; other site 768492001101 C-subunit interface; other site 768492001102 distal quinone binding site; other site 768492001103 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 768492001104 D-subunit interface [polypeptide binding]; other site 768492001105 Iron-sulfur protein interface; other site 768492001106 proximal quinone binding site [chemical binding]; other site 768492001107 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 768492001108 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 768492001109 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 768492001110 L-aspartate oxidase; Provisional; Region: PRK06175 768492001111 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 768492001112 poxB regulator PoxA; Provisional; Region: PRK09350 768492001113 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 768492001114 motif 1; other site 768492001115 dimer interface [polypeptide binding]; other site 768492001116 active site 768492001117 motif 2; other site 768492001118 motif 3; other site 768492001119 putative mechanosensitive channel protein; Provisional; Region: PRK10929 768492001120 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 768492001121 Mechanosensitive ion channel; Region: MS_channel; pfam00924 768492001122 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 768492001123 GTPase RsgA; Reviewed; Region: PRK12288 768492001124 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 768492001125 RNA binding site [nucleotide binding]; other site 768492001126 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 768492001127 GTPase/Zn-binding domain interface [polypeptide binding]; other site 768492001128 GTP/Mg2+ binding site [chemical binding]; other site 768492001129 G4 box; other site 768492001130 G5 box; other site 768492001131 G1 box; other site 768492001132 Switch I region; other site 768492001133 G2 box; other site 768492001134 G3 box; other site 768492001135 Switch II region; other site 768492001136 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 768492001137 catalytic site [active] 768492001138 putative active site [active] 768492001139 putative substrate binding site [chemical binding]; other site 768492001140 dimer interface [polypeptide binding]; other site 768492001141 epoxyqueuosine reductase; Region: TIGR00276 768492001142 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 768492001143 putative carbohydrate kinase; Provisional; Region: PRK10565 768492001144 Uncharacterized conserved protein [Function unknown]; Region: COG0062 768492001145 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 768492001146 putative substrate binding site [chemical binding]; other site 768492001147 putative ATP binding site [chemical binding]; other site 768492001148 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 768492001149 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 768492001150 AMIN domain; Region: AMIN; pfam11741 768492001151 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 768492001152 active site 768492001153 metal binding site [ion binding]; metal-binding site 768492001154 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768492001155 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 768492001156 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492001157 ATP binding site [chemical binding]; other site 768492001158 Mg2+ binding site [ion binding]; other site 768492001159 G-X-G motif; other site 768492001160 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 768492001161 ATP binding site [chemical binding]; other site 768492001162 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 768492001163 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 768492001164 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 768492001165 bacterial Hfq-like; Region: Hfq; cd01716 768492001166 hexamer interface [polypeptide binding]; other site 768492001167 Sm1 motif; other site 768492001168 RNA binding site [nucleotide binding]; other site 768492001169 Sm2 motif; other site 768492001170 GTPase HflX; Provisional; Region: PRK11058 768492001171 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 768492001172 HflX GTPase family; Region: HflX; cd01878 768492001173 G1 box; other site 768492001174 GTP/Mg2+ binding site [chemical binding]; other site 768492001175 Switch I region; other site 768492001176 G2 box; other site 768492001177 G3 box; other site 768492001178 Switch II region; other site 768492001179 G4 box; other site 768492001180 G5 box; other site 768492001181 FtsH protease regulator HflK; Provisional; Region: PRK10930 768492001182 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 768492001183 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 768492001184 FtsH protease regulator HflC; Provisional; Region: PRK11029 768492001185 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 768492001186 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 768492001187 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 768492001188 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 768492001189 GDP-binding site [chemical binding]; other site 768492001190 ACT binding site; other site 768492001191 IMP binding site; other site 768492001192 transcriptional repressor NsrR; Provisional; Region: PRK11014 768492001193 Rrf2 family protein; Region: rrf2_super; TIGR00738 768492001194 exoribonuclease R; Provisional; Region: PRK11642 768492001195 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 768492001196 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 768492001197 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 768492001198 RNB domain; Region: RNB; pfam00773 768492001199 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 768492001200 RNA binding site [nucleotide binding]; other site 768492001201 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 768492001202 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 768492001203 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 768492001204 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 768492001205 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 768492001206 FAD binding site [chemical binding]; other site 768492001207 substrate binding site [chemical binding]; other site 768492001208 catalytic residues [active] 768492001209 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 768492001210 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 768492001211 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 768492001212 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 768492001213 esterase; Provisional; Region: PRK10566 768492001214 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 768492001215 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 768492001216 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 768492001217 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 768492001218 dimer interface [polypeptide binding]; other site 768492001219 ssDNA binding site [nucleotide binding]; other site 768492001220 tetramer (dimer of dimers) interface [polypeptide binding]; other site 768492001221 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 768492001222 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 768492001223 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 768492001224 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 768492001225 Protein of unknown function, DUF488; Region: DUF488; cl01246 768492001226 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 768492001227 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 768492001228 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 768492001229 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 768492001230 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 768492001231 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 768492001232 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 768492001233 Hemerythrin-like domain; Region: Hr-like; cd12108 768492001234 Fe binding site [ion binding]; other site 768492001235 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 768492001236 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 768492001237 active site 768492001238 metal binding site [ion binding]; metal-binding site 768492001239 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 768492001240 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 768492001241 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 768492001242 active site 768492001243 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl17398 768492001244 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 768492001245 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 768492001246 Domain of unknown function DUF21; Region: DUF21; pfam01595 768492001247 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 768492001248 Transporter associated domain; Region: CorC_HlyC; smart01091 768492001249 methionine sulfoxide reductase A; Provisional; Region: PRK00058 768492001250 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 768492001251 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768492001252 Surface antigen; Region: Bac_surface_Ag; pfam01103 768492001253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 768492001254 Family of unknown function (DUF490); Region: DUF490; pfam04357 768492001255 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 768492001256 putative active site pocket [active] 768492001257 dimerization interface [polypeptide binding]; other site 768492001258 putative catalytic residue [active] 768492001259 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 768492001260 dimer interface [polypeptide binding]; other site 768492001261 substrate binding site [chemical binding]; other site 768492001262 metal binding sites [ion binding]; metal-binding site 768492001263 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 768492001264 ligand binding site [chemical binding]; other site 768492001265 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768492001266 dimerization interface [polypeptide binding]; other site 768492001267 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768492001268 dimer interface [polypeptide binding]; other site 768492001269 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 768492001270 putative CheW interface [polypeptide binding]; other site 768492001271 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 768492001272 AMP binding site [chemical binding]; other site 768492001273 metal binding site [ion binding]; metal-binding site 768492001274 active site 768492001275 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 768492001276 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 768492001277 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768492001278 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768492001279 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 768492001280 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 768492001281 arginine repressor; Provisional; Region: PRK05066 768492001282 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 768492001283 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 768492001284 malate dehydrogenase; Provisional; Region: PRK05086 768492001285 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 768492001286 NAD binding site [chemical binding]; other site 768492001287 dimerization interface [polypeptide binding]; other site 768492001288 Substrate binding site [chemical binding]; other site 768492001289 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 768492001290 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 768492001291 Protein of unknown function (DUF447); Region: DUF447; cl17801 768492001292 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 768492001293 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 768492001294 substrate binding pocket [chemical binding]; other site 768492001295 chain length determination region; other site 768492001296 substrate-Mg2+ binding site; other site 768492001297 catalytic residues [active] 768492001298 aspartate-rich region 1; other site 768492001299 active site lid residues [active] 768492001300 aspartate-rich region 2; other site 768492001301 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 768492001302 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 768492001303 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768492001304 EamA-like transporter family; Region: EamA; pfam00892 768492001305 GTPase CgtA; Reviewed; Region: obgE; PRK12298 768492001306 GTP1/OBG; Region: GTP1_OBG; pfam01018 768492001307 Obg GTPase; Region: Obg; cd01898 768492001308 G1 box; other site 768492001309 GTP/Mg2+ binding site [chemical binding]; other site 768492001310 Switch I region; other site 768492001311 G2 box; other site 768492001312 G3 box; other site 768492001313 Switch II region; other site 768492001314 G4 box; other site 768492001315 G5 box; other site 768492001316 sensor protein BasS/PmrB; Provisional; Region: PRK10755 768492001317 HAMP domain; Region: HAMP; pfam00672 768492001318 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492001319 dimer interface [polypeptide binding]; other site 768492001320 phosphorylation site [posttranslational modification] 768492001321 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492001322 ATP binding site [chemical binding]; other site 768492001323 Mg2+ binding site [ion binding]; other site 768492001324 G-X-G motif; other site 768492001325 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 768492001326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492001327 active site 768492001328 phosphorylation site [posttranslational modification] 768492001329 intermolecular recognition site; other site 768492001330 dimerization interface [polypeptide binding]; other site 768492001331 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768492001332 DNA binding site [nucleotide binding] 768492001333 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 768492001334 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 768492001335 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 768492001336 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 768492001337 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 768492001338 RNA-binding protein YhbY; Provisional; Region: PRK10343 768492001339 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 768492001340 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492001341 S-adenosylmethionine binding site [chemical binding]; other site 768492001342 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 768492001343 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492001344 Walker A motif; other site 768492001345 ATP binding site [chemical binding]; other site 768492001346 Walker B motif; other site 768492001347 arginine finger; other site 768492001348 Peptidase family M41; Region: Peptidase_M41; pfam01434 768492001349 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 768492001350 dihydropteroate synthase; Region: DHPS; TIGR01496 768492001351 substrate binding pocket [chemical binding]; other site 768492001352 dimer interface [polypeptide binding]; other site 768492001353 inhibitor binding site; inhibition site 768492001354 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 768492001355 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 768492001356 active site 768492001357 substrate binding site [chemical binding]; other site 768492001358 metal binding site [ion binding]; metal-binding site 768492001359 Preprotein translocase SecG subunit; Region: SecG; pfam03840 768492001360 ribosome maturation protein RimP; Reviewed; Region: PRK00092 768492001361 Sm and related proteins; Region: Sm_like; cl00259 768492001362 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 768492001363 putative oligomer interface [polypeptide binding]; other site 768492001364 putative RNA binding site [nucleotide binding]; other site 768492001365 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 768492001366 NusA N-terminal domain; Region: NusA_N; pfam08529 768492001367 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 768492001368 RNA binding site [nucleotide binding]; other site 768492001369 homodimer interface [polypeptide binding]; other site 768492001370 NusA-like KH domain; Region: KH_5; pfam13184 768492001371 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 768492001372 G-X-X-G motif; other site 768492001373 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 768492001374 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 768492001375 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 768492001376 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 768492001377 translation initiation factor IF-2; Region: IF-2; TIGR00487 768492001378 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 768492001379 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 768492001380 G1 box; other site 768492001381 putative GEF interaction site [polypeptide binding]; other site 768492001382 GTP/Mg2+ binding site [chemical binding]; other site 768492001383 Switch I region; other site 768492001384 G2 box; other site 768492001385 G3 box; other site 768492001386 Switch II region; other site 768492001387 G4 box; other site 768492001388 G5 box; other site 768492001389 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 768492001390 Translation-initiation factor 2; Region: IF-2; pfam11987 768492001391 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 768492001392 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 768492001393 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 768492001394 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 768492001395 RNA binding site [nucleotide binding]; other site 768492001396 active site 768492001397 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 768492001398 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 768492001399 16S/18S rRNA binding site [nucleotide binding]; other site 768492001400 S13e-L30e interaction site [polypeptide binding]; other site 768492001401 25S rRNA binding site [nucleotide binding]; other site 768492001402 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 768492001403 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 768492001404 RNase E interface [polypeptide binding]; other site 768492001405 trimer interface [polypeptide binding]; other site 768492001406 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 768492001407 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 768492001408 RNase E interface [polypeptide binding]; other site 768492001409 trimer interface [polypeptide binding]; other site 768492001410 active site 768492001411 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 768492001412 putative nucleic acid binding region [nucleotide binding]; other site 768492001413 G-X-X-G motif; other site 768492001414 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 768492001415 RNA binding site [nucleotide binding]; other site 768492001416 domain interface; other site 768492001417 lipoprotein NlpI; Provisional; Region: PRK11189 768492001418 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768492001419 binding surface 768492001420 TPR motif; other site 768492001421 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 768492001422 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 768492001423 ATP binding site [chemical binding]; other site 768492001424 Mg++ binding site [ion binding]; other site 768492001425 motif III; other site 768492001426 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768492001427 nucleotide binding region [chemical binding]; other site 768492001428 ATP-binding site [chemical binding]; other site 768492001429 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 768492001430 putative RNA binding site [nucleotide binding]; other site 768492001431 putative inner membrane protein; Provisional; Region: PRK11099 768492001432 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 768492001433 CPxP motif; other site 768492001434 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492001435 non-specific DNA binding site [nucleotide binding]; other site 768492001436 salt bridge; other site 768492001437 sequence-specific DNA binding site [nucleotide binding]; other site 768492001438 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492001439 putative substrate translocation pore; other site 768492001440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492001441 hypothetical protein; Provisional; Region: PRK10508 768492001442 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 768492001443 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 768492001444 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 768492001445 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 768492001446 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768492001447 HlyD family secretion protein; Region: HlyD_3; pfam13437 768492001448 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 768492001449 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 768492001450 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 768492001451 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 768492001452 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768492001453 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 768492001454 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 768492001455 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 768492001456 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 768492001457 active site 768492001458 putative protease; Provisional; Region: PRK15447 768492001459 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 768492001460 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 768492001461 Peptidase family U32; Region: Peptidase_U32; pfam01136 768492001462 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 768492001463 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492001464 Coenzyme A binding pocket [chemical binding]; other site 768492001465 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 768492001466 GIY-YIG motif/motif A; other site 768492001467 putative active site [active] 768492001468 putative metal binding site [ion binding]; other site 768492001469 hypothetical protein; Provisional; Region: PRK03467 768492001470 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 768492001471 NADH(P)-binding; Region: NAD_binding_10; pfam13460 768492001472 NAD binding site [chemical binding]; other site 768492001473 active site 768492001474 putative hydrolase; Provisional; Region: PRK02113 768492001475 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 768492001476 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 768492001477 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 768492001478 trimer interface [polypeptide binding]; other site 768492001479 active site 768492001480 substrate binding site [chemical binding]; other site 768492001481 CoA binding site [chemical binding]; other site 768492001482 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 768492001483 AAA domain; Region: AAA_18; pfam13238 768492001484 active site 768492001485 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 768492001486 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 768492001487 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 768492001488 active site 768492001489 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 768492001490 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768492001491 Walker A/P-loop; other site 768492001492 ATP binding site [chemical binding]; other site 768492001493 Q-loop/lid; other site 768492001494 ABC transporter signature motif; other site 768492001495 Walker B; other site 768492001496 D-loop; other site 768492001497 H-loop/switch region; other site 768492001498 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 768492001499 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768492001500 Walker A/P-loop; other site 768492001501 ATP binding site [chemical binding]; other site 768492001502 Q-loop/lid; other site 768492001503 ABC transporter signature motif; other site 768492001504 Walker B; other site 768492001505 D-loop; other site 768492001506 H-loop/switch region; other site 768492001507 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768492001508 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 768492001509 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 768492001510 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845 768492001511 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 768492001512 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 768492001513 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492001514 DNA-binding site [nucleotide binding]; DNA binding site 768492001515 UTRA domain; Region: UTRA; pfam07702 768492001516 Predicted permease; Region: DUF318; cl17795 768492001517 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 768492001518 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 768492001519 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768492001520 FeS/SAM binding site; other site 768492001521 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 768492001522 ATP cone domain; Region: ATP-cone; pfam03477 768492001523 Class III ribonucleotide reductase; Region: RNR_III; cd01675 768492001524 effector binding site; other site 768492001525 active site 768492001526 Zn binding site [ion binding]; other site 768492001527 glycine loop; other site 768492001528 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492001529 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492001530 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492001531 putative effector binding pocket; other site 768492001532 dimerization interface [polypeptide binding]; other site 768492001533 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 768492001534 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 768492001535 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 768492001536 Ca binding site [ion binding]; other site 768492001537 active site 768492001538 catalytic site [active] 768492001539 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 768492001540 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 768492001541 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768492001542 active site turn [active] 768492001543 phosphorylation site [posttranslational modification] 768492001544 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768492001545 trehalose repressor; Provisional; Region: treR; PRK09492 768492001546 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492001547 DNA binding site [nucleotide binding] 768492001548 domain linker motif; other site 768492001549 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 768492001550 dimerization interface [polypeptide binding]; other site 768492001551 ligand binding site [chemical binding]; other site 768492001552 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 768492001553 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 768492001554 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768492001555 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 768492001556 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492001557 motif II; other site 768492001558 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 768492001559 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 768492001560 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 768492001561 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 768492001562 active site 768492001563 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 768492001564 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 768492001565 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 768492001566 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 768492001567 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 768492001568 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 768492001569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 768492001570 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 768492001571 Uncharacterized conserved protein [Function unknown]; Region: COG2308 768492001572 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 768492001573 homotrimer interaction site [polypeptide binding]; other site 768492001574 putative active site [active] 768492001575 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 768492001576 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 768492001577 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 768492001578 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 768492001579 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 768492001580 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 768492001581 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 768492001582 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 768492001583 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 768492001584 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 768492001585 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 768492001586 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 768492001587 RNase E inhibitor protein; Provisional; Region: PRK11191 768492001588 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 768492001589 active site 768492001590 dinuclear metal binding site [ion binding]; other site 768492001591 dimerization interface [polypeptide binding]; other site 768492001592 choline dehydrogenase; Validated; Region: PRK02106 768492001593 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768492001594 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 768492001595 Acyltransferase family; Region: Acyl_transf_3; pfam01757 768492001596 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768492001597 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492001598 Coenzyme A binding pocket [chemical binding]; other site 768492001599 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 768492001600 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 768492001601 HIGH motif; other site 768492001602 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 768492001603 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 768492001604 active site 768492001605 KMSKS motif; other site 768492001606 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 768492001607 tRNA binding surface [nucleotide binding]; other site 768492001608 anticodon binding site; other site 768492001609 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 768492001610 DNA polymerase III subunit chi; Validated; Region: PRK05728 768492001611 multifunctional aminopeptidase A; Provisional; Region: PRK00913 768492001612 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 768492001613 interface (dimer of trimers) [polypeptide binding]; other site 768492001614 Substrate-binding/catalytic site; other site 768492001615 Zn-binding sites [ion binding]; other site 768492001616 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 768492001617 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 768492001618 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 768492001619 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 768492001620 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 768492001621 active site clefts [active] 768492001622 zinc binding site [ion binding]; other site 768492001623 dimer interface [polypeptide binding]; other site 768492001624 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768492001625 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492001626 non-specific DNA binding site [nucleotide binding]; other site 768492001627 salt bridge; other site 768492001628 sequence-specific DNA binding site [nucleotide binding]; other site 768492001629 HipA N-terminal domain; Region: Couple_hipA; pfam13657 768492001630 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 768492001631 HipA-like N-terminal domain; Region: HipA_N; pfam07805 768492001632 HipA-like C-terminal domain; Region: HipA_C; pfam07804 768492001633 Z1 domain; Region: Z1; pfam10593 768492001634 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 768492001635 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 768492001636 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 768492001637 cofactor binding site; other site 768492001638 DNA binding site [nucleotide binding] 768492001639 substrate interaction site [chemical binding]; other site 768492001640 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 768492001641 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 768492001642 additional DNA contacts [nucleotide binding]; other site 768492001643 mismatch recognition site; other site 768492001644 active site 768492001645 zinc binding site [ion binding]; other site 768492001646 DNA intercalation site [nucleotide binding]; other site 768492001647 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 768492001648 beta-galactosidase; Region: BGL; TIGR03356 768492001649 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 768492001650 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768492001651 active site turn [active] 768492001652 phosphorylation site [posttranslational modification] 768492001653 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 768492001654 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768492001655 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492001656 DNA binding site [nucleotide binding] 768492001657 domain linker motif; other site 768492001658 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 768492001659 dimerization interface (closed form) [polypeptide binding]; other site 768492001660 ligand binding site [chemical binding]; other site 768492001661 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 768492001662 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 768492001663 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 768492001664 Uncharacterized small protein [Function unknown]; Region: COG2879 768492001665 carbon starvation protein A; Provisional; Region: PRK15015 768492001666 Carbon starvation protein CstA; Region: CstA; pfam02554 768492001667 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 768492001668 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 768492001669 Beta-lactamase; Region: Beta-lactamase; pfam00144 768492001670 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 768492001671 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 768492001672 active site 768492001673 dimer interface [polypeptide binding]; other site 768492001674 non-prolyl cis peptide bond; other site 768492001675 insertion regions; other site 768492001676 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 768492001677 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 768492001678 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492001679 Coenzyme A binding pocket [chemical binding]; other site 768492001680 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 768492001681 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 768492001682 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 768492001683 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492001684 non-specific DNA binding site [nucleotide binding]; other site 768492001685 salt bridge; other site 768492001686 sequence-specific DNA binding site [nucleotide binding]; other site 768492001687 PQQ-like domain; Region: PQQ_2; pfam13360 768492001688 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 768492001689 putative transporter; Provisional; Region: PRK11043 768492001690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492001691 putative substrate translocation pore; other site 768492001692 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 768492001693 Cytochrome P450; Region: p450; cl12078 768492001694 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 768492001695 Predicted flavoprotein [General function prediction only]; Region: COG0431 768492001696 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768492001697 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 768492001698 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 768492001699 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 768492001700 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 768492001701 active site 768492001702 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 768492001703 acyl-CoA synthetase; Validated; Region: PRK05850 768492001704 acyl-activating enzyme (AAE) consensus motif; other site 768492001705 active site 768492001706 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 768492001707 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768492001708 thioester reductase domain; Region: Thioester-redct; TIGR01746 768492001709 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 768492001710 putative NAD(P) binding site [chemical binding]; other site 768492001711 active site 768492001712 putative substrate binding site [chemical binding]; other site 768492001713 Condensation domain; Region: Condensation; pfam00668 768492001714 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 768492001715 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 768492001716 acyl-activating enzyme (AAE) consensus motif; other site 768492001717 AMP binding site [chemical binding]; other site 768492001718 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768492001719 Condensation domain; Region: Condensation; pfam00668 768492001720 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 768492001721 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 768492001722 acyl-activating enzyme (AAE) consensus motif; other site 768492001723 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 768492001724 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 768492001725 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 768492001726 AMP binding site [chemical binding]; other site 768492001727 Methyltransferase domain; Region: Methyltransf_23; pfam13489 768492001728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492001729 S-adenosylmethionine binding site [chemical binding]; other site 768492001730 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768492001731 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768492001732 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 768492001733 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492001734 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492001735 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 768492001736 L,D-transpeptidase; Provisional; Region: PRK10260 768492001737 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 768492001738 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 768492001739 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 768492001740 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 768492001741 Gram-negative bacterial tonB protein; Region: TonB; cl10048 768492001742 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 768492001743 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768492001744 N-terminal plug; other site 768492001745 ligand-binding site [chemical binding]; other site 768492001746 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 768492001747 Putative catalytic domain, repeat 1, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_1; cd09106 768492001748 PLD-like domain; Region: PLDc_2; pfam13091 768492001749 putative active site [active] 768492001750 putative catalytic site [active] 768492001751 Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_2; cd09107 768492001752 PLD-like domain; Region: PLDc_2; pfam13091 768492001753 putative active site [active] 768492001754 putative catalytic site [active] 768492001755 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 768492001756 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768492001757 inhibitor-cofactor binding pocket; inhibition site 768492001758 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492001759 catalytic residue [active] 768492001760 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492001761 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492001762 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768492001763 dimerization interface [polypeptide binding]; other site 768492001764 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 768492001765 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 768492001766 active site 768492001767 NAD binding site [chemical binding]; other site 768492001768 metal binding site [ion binding]; metal-binding site 768492001769 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768492001770 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492001771 DNA binding residues [nucleotide binding] 768492001772 dimerization interface [polypeptide binding]; other site 768492001773 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 768492001774 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 768492001775 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 768492001776 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 768492001777 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 768492001778 PGAP1-like protein; Region: PGAP1; pfam07819 768492001779 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 768492001780 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 768492001781 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 768492001782 active site 768492001783 Zn binding site [ion binding]; other site 768492001784 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768492001785 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768492001786 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492001787 DNA binding residues [nucleotide binding] 768492001788 dimerization interface [polypeptide binding]; other site 768492001789 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 768492001790 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 768492001791 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 768492001792 classical (c) SDRs; Region: SDR_c; cd05233 768492001793 NAD(P) binding site [chemical binding]; other site 768492001794 active site 768492001795 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 768492001796 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 768492001797 classical (c) SDRs; Region: SDR_c; cd05233 768492001798 NAD(P) binding site [chemical binding]; other site 768492001799 active site 768492001800 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 768492001801 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768492001802 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 768492001803 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 768492001804 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 768492001805 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 768492001806 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 768492001807 NAD binding site [chemical binding]; other site 768492001808 catalytic residues [active] 768492001809 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 768492001810 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 768492001811 tetramer interface [polypeptide binding]; other site 768492001812 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 768492001813 tetramer interface [polypeptide binding]; other site 768492001814 active site 768492001815 metal binding site [ion binding]; metal-binding site 768492001816 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 768492001817 putative substrate binding pocket [chemical binding]; other site 768492001818 trimer interface [polypeptide binding]; other site 768492001819 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 768492001820 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Region: HpaI; TIGR02311 768492001821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492001822 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 768492001823 putative substrate translocation pore; other site 768492001824 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 768492001825 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768492001826 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492001827 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 768492001828 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 768492001829 Flavin Reductases; Region: FlaRed; cl00801 768492001830 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 768492001831 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 768492001832 Transcriptional regulators [Transcription]; Region: FadR; COG2186 768492001833 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492001834 DNA-binding site [nucleotide binding]; DNA binding site 768492001835 FCD domain; Region: FCD; pfam07729 768492001836 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 768492001837 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 768492001838 NAD binding site [chemical binding]; other site 768492001839 homotetramer interface [polypeptide binding]; other site 768492001840 homodimer interface [polypeptide binding]; other site 768492001841 active site 768492001842 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 768492001843 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 768492001844 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 768492001845 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 768492001846 putative active site pocket [active] 768492001847 metal binding site [ion binding]; metal-binding site 768492001848 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 768492001849 Amidohydrolase; Region: Amidohydro_2; pfam04909 768492001850 active site 768492001851 short chain dehydrogenase; Provisional; Region: PRK08628 768492001852 classical (c) SDRs; Region: SDR_c; cd05233 768492001853 NAD(P) binding site [chemical binding]; other site 768492001854 active site 768492001855 Domain of unknown function (DUF718); Region: DUF718; pfam05336 768492001856 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 768492001857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492001858 putative substrate translocation pore; other site 768492001859 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768492001860 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492001861 putative substrate translocation pore; other site 768492001862 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492001863 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492001864 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492001865 putative effector binding pocket; other site 768492001866 dimerization interface [polypeptide binding]; other site 768492001867 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768492001868 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492001869 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768492001870 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768492001871 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768492001872 metal binding site [ion binding]; metal-binding site 768492001873 active site 768492001874 I-site; other site 768492001875 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 768492001876 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492001877 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492001878 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 768492001879 putative effector binding pocket; other site 768492001880 putative dimerization interface [polypeptide binding]; other site 768492001881 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768492001882 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768492001883 active site 768492001884 catalytic tetrad [active] 768492001885 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 768492001886 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 768492001887 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492001888 S-adenosylmethionine binding site [chemical binding]; other site 768492001889 DNA polymerase III subunit psi; Validated; Region: PRK06856 768492001890 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 768492001891 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492001892 Coenzyme A binding pocket [chemical binding]; other site 768492001893 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492001894 non-specific DNA binding site [nucleotide binding]; other site 768492001895 salt bridge; other site 768492001896 sequence-specific DNA binding site [nucleotide binding]; other site 768492001897 HipA N-terminal domain; Region: Couple_hipA; pfam13657 768492001898 HipA-like N-terminal domain; Region: HipA_N; pfam07805 768492001899 HipA-like C-terminal domain; Region: HipA_C; pfam07804 768492001900 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 768492001901 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 768492001902 G1 box; other site 768492001903 putative GEF interaction site [polypeptide binding]; other site 768492001904 GTP/Mg2+ binding site [chemical binding]; other site 768492001905 Switch I region; other site 768492001906 G2 box; other site 768492001907 G3 box; other site 768492001908 Switch II region; other site 768492001909 G4 box; other site 768492001910 G5 box; other site 768492001911 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 768492001912 periplasmic protein; Provisional; Region: PRK10568 768492001913 BON domain; Region: BON; pfam04972 768492001914 BON domain; Region: BON; pfam04972 768492001915 CsbD-like; Region: CsbD; cl17424 768492001916 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 768492001917 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 768492001918 active site 768492001919 nucleophile elbow; other site 768492001920 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 768492001921 active site 768492001922 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 768492001923 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 768492001924 Nucleoside recognition; Region: Gate; pfam07670 768492001925 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 768492001926 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 768492001927 intersubunit interface [polypeptide binding]; other site 768492001928 active site 768492001929 catalytic residue [active] 768492001930 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 768492001931 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 768492001932 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 768492001933 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 768492001934 phosphopentomutase; Provisional; Region: PRK05362 768492001935 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 768492001936 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 768492001937 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 768492001938 Bacterial virulence factor haemolysin; Region: SMP_2; cl11479 768492001939 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 768492001940 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 768492001941 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492001942 motif II; other site 768492001943 DNA repair protein RadA; Provisional; Region: PRK11823 768492001944 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 768492001945 Walker A motif/ATP binding site; other site 768492001946 ATP binding site [chemical binding]; other site 768492001947 Walker B motif; other site 768492001948 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 768492001949 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492001950 non-specific DNA binding site [nucleotide binding]; other site 768492001951 salt bridge; other site 768492001952 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 768492001953 sequence-specific DNA binding site [nucleotide binding]; other site 768492001954 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768492001955 active site 768492001956 nucleotide binding site [chemical binding]; other site 768492001957 HIGH motif; other site 768492001958 KMSKS motif; other site 768492001959 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 768492001960 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 768492001961 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 768492001962 putative NAD(P) binding site [chemical binding]; other site 768492001963 dimer interface [polypeptide binding]; other site 768492001964 LysR family transcriptional regulator; Provisional; Region: PRK14997 768492001965 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492001966 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492001967 putative effector binding pocket; other site 768492001968 dimerization interface [polypeptide binding]; other site 768492001969 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 768492001970 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768492001971 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768492001972 ABC transporter; Region: ABC_tran_2; pfam12848 768492001973 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768492001974 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 768492001975 ligand binding site [chemical binding]; other site 768492001976 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 768492001977 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 768492001978 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768492001979 metal binding site [ion binding]; metal-binding site 768492001980 active site 768492001981 I-site; other site 768492001982 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 768492001983 lytic murein transglycosylase; Provisional; Region: PRK11619 768492001984 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768492001985 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768492001986 catalytic residue [active] 768492001987 Trp operon repressor; Provisional; Region: PRK01381 768492001988 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 768492001989 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768492001990 catalytic core [active] 768492001991 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 768492001992 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492001993 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 768492001994 hypothetical protein; Provisional; Region: PRK10756 768492001995 CreA protein; Region: CreA; pfam05981 768492001996 two-component response regulator; Provisional; Region: PRK11173 768492001997 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492001998 active site 768492001999 phosphorylation site [posttranslational modification] 768492002000 intermolecular recognition site; other site 768492002001 dimerization interface [polypeptide binding]; other site 768492002002 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768492002003 DNA binding site [nucleotide binding] 768492002004 putative RNA methyltransferase; Provisional; Region: PRK10433 768492002005 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 768492002006 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 768492002007 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 768492002008 putative catalytic residues [active] 768492002009 putative nucleotide binding site [chemical binding]; other site 768492002010 putative aspartate binding site [chemical binding]; other site 768492002011 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 768492002012 dimer interface [polypeptide binding]; other site 768492002013 putative threonine allosteric regulatory site; other site 768492002014 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 768492002015 putative threonine allosteric regulatory site; other site 768492002016 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 768492002017 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 768492002018 homoserine kinase; Provisional; Region: PRK01212 768492002019 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 768492002020 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 768492002021 threonine synthase; Validated; Region: PRK09225 768492002022 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 768492002023 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492002024 catalytic residue [active] 768492002025 hypothetical protein; Validated; Region: PRK02101 768492002026 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 768492002027 amino acid carrier protein; Region: agcS; TIGR00835 768492002028 transaldolase-like protein; Provisional; Region: PTZ00411 768492002029 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 768492002030 active site 768492002031 dimer interface [polypeptide binding]; other site 768492002032 catalytic residue [active] 768492002033 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 768492002034 MPT binding site; other site 768492002035 trimer interface [polypeptide binding]; other site 768492002036 metabolite-proton symporter; Region: 2A0106; TIGR00883 768492002037 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492002038 putative substrate translocation pore; other site 768492002039 hypothetical protein; Provisional; Region: PRK10659 768492002040 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 768492002041 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 768492002042 nucleotide binding site [chemical binding]; other site 768492002043 chaperone protein DnaJ; Provisional; Region: PRK10767 768492002044 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 768492002045 HSP70 interaction site [polypeptide binding]; other site 768492002046 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 768492002047 substrate binding site [polypeptide binding]; other site 768492002048 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 768492002049 Zn binding sites [ion binding]; other site 768492002050 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 768492002051 dimer interface [polypeptide binding]; other site 768492002052 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 768492002053 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 768492002054 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492002055 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 768492002056 putative dimerization interface [polypeptide binding]; other site 768492002057 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 768492002058 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 768492002059 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 768492002060 active site 768492002061 Riboflavin kinase; Region: Flavokinase; smart00904 768492002062 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 768492002063 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768492002064 active site 768492002065 HIGH motif; other site 768492002066 nucleotide binding site [chemical binding]; other site 768492002067 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 768492002068 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 768492002069 active site 768492002070 KMSKS motif; other site 768492002071 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 768492002072 tRNA binding surface [nucleotide binding]; other site 768492002073 anticodon binding site; other site 768492002074 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 768492002075 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 768492002076 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 768492002077 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 768492002078 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 768492002079 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 768492002080 transcriptional regulator; Provisional; Region: PRK10632 768492002081 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492002082 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492002083 putative effector binding pocket; other site 768492002084 dimerization interface [polypeptide binding]; other site 768492002085 Pyoverdine/dityrosine biosynthesis protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: DIT1; COG3207 768492002086 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 768492002087 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 768492002088 substrate binding pocket [chemical binding]; other site 768492002089 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 768492002090 active site 768492002091 iron coordination sites [ion binding]; other site 768492002092 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 768492002093 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 768492002094 active site 768492002095 TDP-binding site; other site 768492002096 acceptor substrate-binding pocket; other site 768492002097 dihydrodipicolinate reductase; Provisional; Region: PRK00048 768492002098 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 768492002099 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 768492002100 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 768492002101 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 768492002102 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 768492002103 catalytic site [active] 768492002104 subunit interface [polypeptide binding]; other site 768492002105 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 768492002106 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 768492002107 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 768492002108 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 768492002109 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 768492002110 ATP-grasp domain; Region: ATP-grasp_4; cl17255 768492002111 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 768492002112 IMP binding site; other site 768492002113 dimer interface [polypeptide binding]; other site 768492002114 interdomain contacts; other site 768492002115 partial ornithine binding site; other site 768492002116 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 768492002117 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768492002118 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 768492002119 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 768492002120 TrkA-N domain; Region: TrkA_N; pfam02254 768492002121 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 768492002122 Uncharacterized conserved protein [Function unknown]; Region: COG2966 768492002123 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 768492002124 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 768492002125 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 768492002126 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 768492002127 folate binding site [chemical binding]; other site 768492002128 NADP+ binding site [chemical binding]; other site 768492002129 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 768492002130 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 768492002131 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 768492002132 active site 768492002133 metal binding site [ion binding]; metal-binding site 768492002134 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 768492002135 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 768492002136 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 768492002137 S-adenosylmethionine binding site [chemical binding]; other site 768492002138 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 768492002139 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 768492002140 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 768492002141 SurA N-terminal domain; Region: SurA_N; pfam09312 768492002142 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 768492002143 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 768492002144 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 768492002145 OstA-like protein; Region: OstA; pfam03968 768492002146 Organic solvent tolerance protein; Region: OstA_C; pfam04453 768492002147 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 768492002148 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 768492002149 putative metal binding site [ion binding]; other site 768492002150 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 768492002151 HSP70 interaction site [polypeptide binding]; other site 768492002152 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 768492002153 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 768492002154 active site 768492002155 ATP-dependent helicase HepA; Validated; Region: PRK04914 768492002156 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768492002157 ATP binding site [chemical binding]; other site 768492002158 putative Mg++ binding site [ion binding]; other site 768492002159 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768492002160 nucleotide binding region [chemical binding]; other site 768492002161 ATP-binding site [chemical binding]; other site 768492002162 DNA polymerase II; Reviewed; Region: PRK05762 768492002163 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 768492002164 active site 768492002165 catalytic site [active] 768492002166 substrate binding site [chemical binding]; other site 768492002167 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 768492002168 active site 768492002169 metal-binding site 768492002170 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 768492002171 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 768492002172 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 768492002173 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 768492002174 putative valine binding site [chemical binding]; other site 768492002175 dimer interface [polypeptide binding]; other site 768492002176 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 768492002177 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768492002178 PYR/PP interface [polypeptide binding]; other site 768492002179 dimer interface [polypeptide binding]; other site 768492002180 TPP binding site [chemical binding]; other site 768492002181 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768492002182 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 768492002183 TPP-binding site [chemical binding]; other site 768492002184 dimer interface [polypeptide binding]; other site 768492002185 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 768492002186 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768492002187 Walker A/P-loop; other site 768492002188 ATP binding site [chemical binding]; other site 768492002189 Q-loop/lid; other site 768492002190 ABC transporter signature motif; other site 768492002191 Walker B; other site 768492002192 D-loop; other site 768492002193 H-loop/switch region; other site 768492002194 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 768492002195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492002196 putative PBP binding loops; other site 768492002197 ABC-ATPase subunit interface; other site 768492002198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492002199 dimer interface [polypeptide binding]; other site 768492002200 conserved gate region; other site 768492002201 putative PBP binding loops; other site 768492002202 ABC-ATPase subunit interface; other site 768492002203 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 768492002204 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 768492002205 transcriptional regulator SgrR; Provisional; Region: PRK13626 768492002206 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 768492002207 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 768492002208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492002209 sugar efflux transporter; Region: 2A0120; TIGR00899 768492002210 putative substrate translocation pore; other site 768492002211 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 768492002212 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 768492002213 transmembrane helices; other site 768492002214 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 768492002215 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 768492002216 substrate binding site [chemical binding]; other site 768492002217 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 768492002218 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 768492002219 substrate binding site [chemical binding]; other site 768492002220 ligand binding site [chemical binding]; other site 768492002221 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 768492002222 tartrate dehydrogenase; Region: TTC; TIGR02089 768492002223 2-isopropylmalate synthase; Validated; Region: PRK00915 768492002224 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 768492002225 active site 768492002226 catalytic residues [active] 768492002227 metal binding site [ion binding]; metal-binding site 768492002228 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 768492002229 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 768492002230 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492002231 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 768492002232 putative substrate binding pocket [chemical binding]; other site 768492002233 putative dimerization interface [polypeptide binding]; other site 768492002234 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 768492002235 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 768492002236 acyl-activating enzyme (AAE) consensus motif; other site 768492002237 putative AMP binding site [chemical binding]; other site 768492002238 putative active site [active] 768492002239 putative CoA binding site [chemical binding]; other site 768492002240 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 768492002241 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768492002242 PYR/PP interface [polypeptide binding]; other site 768492002243 dimer interface [polypeptide binding]; other site 768492002244 TPP binding site [chemical binding]; other site 768492002245 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768492002246 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 768492002247 TPP-binding site [chemical binding]; other site 768492002248 dimer interface [polypeptide binding]; other site 768492002249 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 768492002250 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 768492002251 putative valine binding site [chemical binding]; other site 768492002252 dimer interface [polypeptide binding]; other site 768492002253 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 768492002254 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 768492002255 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492002256 DNA binding site [nucleotide binding] 768492002257 domain linker motif; other site 768492002258 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 768492002259 dimerization interface [polypeptide binding]; other site 768492002260 ligand binding site [chemical binding]; other site 768492002261 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 768492002262 cell division protein MraZ; Reviewed; Region: PRK00326 768492002263 MraZ protein; Region: MraZ; pfam02381 768492002264 MraZ protein; Region: MraZ; pfam02381 768492002265 MraW methylase family; Region: Methyltransf_5; pfam01795 768492002266 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 768492002267 cell division protein FtsL; Provisional; Region: PRK10772 768492002268 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 768492002269 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 768492002270 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 768492002271 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 768492002272 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 768492002273 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768492002274 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768492002275 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 768492002276 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 768492002277 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768492002278 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768492002279 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 768492002280 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 768492002281 Mg++ binding site [ion binding]; other site 768492002282 putative catalytic motif [active] 768492002283 putative substrate binding site [chemical binding]; other site 768492002284 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 768492002285 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768492002286 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768492002287 cell division protein FtsW; Provisional; Region: PRK10774 768492002288 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 768492002289 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 768492002290 active site 768492002291 homodimer interface [polypeptide binding]; other site 768492002292 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 768492002293 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 768492002294 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768492002295 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768492002296 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 768492002297 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 768492002298 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 768492002299 cell division protein FtsQ; Provisional; Region: PRK10775 768492002300 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 768492002301 Cell division protein FtsQ; Region: FtsQ; pfam03799 768492002302 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 768492002303 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768492002304 Cell division protein FtsA; Region: FtsA; pfam14450 768492002305 cell division protein FtsZ; Validated; Region: PRK09330 768492002306 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 768492002307 nucleotide binding site [chemical binding]; other site 768492002308 SulA interaction site; other site 768492002309 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 768492002310 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 768492002311 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4701 768492002312 SecA regulator SecM; Provisional; Region: PRK02943 768492002313 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 768492002314 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 768492002315 SEC-C motif; Region: SEC-C; pfam02810 768492002316 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 768492002317 active site 768492002318 8-oxo-dGMP binding site [chemical binding]; other site 768492002319 nudix motif; other site 768492002320 metal binding site [ion binding]; metal-binding site 768492002321 DNA gyrase inhibitor; Reviewed; Region: PRK00418 768492002322 hypothetical protein; Provisional; Region: PRK05287 768492002323 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 768492002324 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 768492002325 CoA-binding site [chemical binding]; other site 768492002326 ATP-binding [chemical binding]; other site 768492002327 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 768492002328 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 768492002329 active site 768492002330 type IV pilin biogenesis protein; Provisional; Region: PRK10573 768492002331 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 768492002332 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 768492002333 hypothetical protein; Provisional; Region: PRK10436 768492002334 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 768492002335 Walker A motif; other site 768492002336 ATP binding site [chemical binding]; other site 768492002337 Walker B motif; other site 768492002338 putative major pilin subunit; Provisional; Region: PRK10574 768492002339 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 768492002340 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 768492002341 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 768492002342 dimerization interface [polypeptide binding]; other site 768492002343 active site 768492002344 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 768492002345 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 768492002346 amidase catalytic site [active] 768492002347 Zn binding residues [ion binding]; other site 768492002348 substrate binding site [chemical binding]; other site 768492002349 regulatory protein AmpE; Provisional; Region: PRK10987 768492002350 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 768492002351 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768492002352 inhibitor-cofactor binding pocket; inhibition site 768492002353 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492002354 catalytic residue [active] 768492002355 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 768492002356 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 768492002357 Cl- selectivity filter; other site 768492002358 Cl- binding residues [ion binding]; other site 768492002359 pore gating glutamate residue; other site 768492002360 dimer interface [polypeptide binding]; other site 768492002361 H+/Cl- coupling transport residue; other site 768492002362 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 768492002363 hypothetical protein; Provisional; Region: PRK10578 768492002364 UPF0126 domain; Region: UPF0126; pfam03458 768492002365 UPF0126 domain; Region: UPF0126; pfam03458 768492002366 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 768492002367 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 768492002368 cobalamin binding residues [chemical binding]; other site 768492002369 putative BtuC binding residues; other site 768492002370 dimer interface [polypeptide binding]; other site 768492002371 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 768492002372 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 768492002373 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 768492002374 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 768492002375 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 768492002376 serine endoprotease; Provisional; Region: PRK10942 768492002377 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 768492002378 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 768492002379 protein binding site [polypeptide binding]; other site 768492002380 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 768492002381 protein binding site [polypeptide binding]; other site 768492002382 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 768492002383 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 768492002384 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768492002385 dimerization interface [polypeptide binding]; other site 768492002386 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492002387 dimer interface [polypeptide binding]; other site 768492002388 phosphorylation site [posttranslational modification] 768492002389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492002390 ATP binding site [chemical binding]; other site 768492002391 Mg2+ binding site [ion binding]; other site 768492002392 G-X-G motif; other site 768492002393 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 768492002394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492002395 active site 768492002396 phosphorylation site [posttranslational modification] 768492002397 intermolecular recognition site; other site 768492002398 dimerization interface [polypeptide binding]; other site 768492002399 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 768492002400 putative binding surface; other site 768492002401 active site 768492002402 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 768492002403 HD domain; Region: HD_4; pfam13328 768492002404 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 768492002405 synthetase active site [active] 768492002406 NTP binding site [chemical binding]; other site 768492002407 metal binding site [ion binding]; metal-binding site 768492002408 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 768492002409 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 768492002410 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 768492002411 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 768492002412 homodimer interface [polypeptide binding]; other site 768492002413 metal binding site [ion binding]; metal-binding site 768492002414 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 768492002415 homodimer interface [polypeptide binding]; other site 768492002416 active site 768492002417 putative chemical substrate binding site [chemical binding]; other site 768492002418 metal binding site [ion binding]; metal-binding site 768492002419 CTP synthetase; Validated; Region: pyrG; PRK05380 768492002420 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 768492002421 Catalytic site [active] 768492002422 active site 768492002423 UTP binding site [chemical binding]; other site 768492002424 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 768492002425 active site 768492002426 putative oxyanion hole; other site 768492002427 catalytic triad [active] 768492002428 enolase; Provisional; Region: eno; PRK00077 768492002429 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 768492002430 dimer interface [polypeptide binding]; other site 768492002431 metal binding site [ion binding]; metal-binding site 768492002432 substrate binding pocket [chemical binding]; other site 768492002433 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 768492002434 methionine gamma-lyase; Provisional; Region: PRK07503 768492002435 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 768492002436 homodimer interface [polypeptide binding]; other site 768492002437 substrate-cofactor binding pocket; other site 768492002438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492002439 catalytic residue [active] 768492002440 putative proline-specific permease; Provisional; Region: proY; PRK10580 768492002441 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 768492002442 active sites [active] 768492002443 tetramer interface [polypeptide binding]; other site 768492002444 urocanate hydratase; Provisional; Region: PRK05414 768492002445 benzoate transport; Region: 2A0115; TIGR00895 768492002446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492002447 putative substrate translocation pore; other site 768492002448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492002449 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 768492002450 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 768492002451 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 768492002452 active site 768492002453 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 768492002454 Flavodoxin; Region: Flavodoxin_1; pfam00258 768492002455 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 768492002456 FAD binding pocket [chemical binding]; other site 768492002457 FAD binding motif [chemical binding]; other site 768492002458 catalytic residues [active] 768492002459 NAD binding pocket [chemical binding]; other site 768492002460 phosphate binding motif [ion binding]; other site 768492002461 beta-alpha-beta structure motif; other site 768492002462 sulfite reductase subunit beta; Provisional; Region: PRK13504 768492002463 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 768492002464 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 768492002465 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 768492002466 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 768492002467 Active Sites [active] 768492002468 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 768492002469 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 768492002470 metal binding site [ion binding]; metal-binding site 768492002471 siroheme synthase; Provisional; Region: cysG; PRK10637 768492002472 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 768492002473 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 768492002474 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 768492002475 active site 768492002476 SAM binding site [chemical binding]; other site 768492002477 homodimer interface [polypeptide binding]; other site 768492002478 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 768492002479 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 768492002480 Active Sites [active] 768492002481 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 768492002482 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 768492002483 CysD dimerization site [polypeptide binding]; other site 768492002484 G1 box; other site 768492002485 putative GEF interaction site [polypeptide binding]; other site 768492002486 GTP/Mg2+ binding site [chemical binding]; other site 768492002487 Switch I region; other site 768492002488 G2 box; other site 768492002489 G3 box; other site 768492002490 Switch II region; other site 768492002491 G4 box; other site 768492002492 G5 box; other site 768492002493 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 768492002494 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 768492002495 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 768492002496 ligand-binding site [chemical binding]; other site 768492002497 hypothetical protein; Provisional; Region: PRK10726 768492002498 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 768492002499 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 768492002500 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 768492002501 substrate binding site; other site 768492002502 dimer interface; other site 768492002503 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 768492002504 homotrimer interaction site [polypeptide binding]; other site 768492002505 zinc binding site [ion binding]; other site 768492002506 CDP-binding sites; other site 768492002507 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 768492002508 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 768492002509 Permutation of conserved domain; other site 768492002510 active site 768492002511 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 768492002512 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 768492002513 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492002514 S-adenosylmethionine binding site [chemical binding]; other site 768492002515 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 768492002516 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768492002517 Peptidase family M23; Region: Peptidase_M23; pfam01551 768492002518 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 768492002519 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 768492002520 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768492002521 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 768492002522 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768492002523 DNA binding residues [nucleotide binding] 768492002524 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 768492002525 MutS domain I; Region: MutS_I; pfam01624 768492002526 MutS domain II; Region: MutS_II; pfam05188 768492002527 MutS domain III; Region: MutS_III; pfam05192 768492002528 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 768492002529 Walker A/P-loop; other site 768492002530 ATP binding site [chemical binding]; other site 768492002531 Q-loop/lid; other site 768492002532 ABC transporter signature motif; other site 768492002533 Walker B; other site 768492002534 D-loop; other site 768492002535 H-loop/switch region; other site 768492002536 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 768492002537 active site 768492002538 P-loop; other site 768492002539 phosphorylation site [posttranslational modification] 768492002540 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 768492002541 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 768492002542 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 768492002543 beta-galactosidase; Region: BGL; TIGR03356 768492002544 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 768492002545 Cupin domain; Region: Cupin_2; pfam07883 768492002546 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492002547 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 768492002548 putative active site [active] 768492002549 YdjC motif; other site 768492002550 Mg binding site [ion binding]; other site 768492002551 putative homodimer interface [polypeptide binding]; other site 768492002552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492002553 putative substrate translocation pore; other site 768492002554 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768492002555 hypothetical protein; Validated; Region: PRK03661 768492002556 recombinase A; Provisional; Region: recA; PRK09354 768492002557 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 768492002558 hexamer interface [polypeptide binding]; other site 768492002559 Walker A motif; other site 768492002560 ATP binding site [chemical binding]; other site 768492002561 Walker B motif; other site 768492002562 recombination regulator RecX; Reviewed; Region: recX; PRK00117 768492002563 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 768492002564 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 768492002565 motif 1; other site 768492002566 active site 768492002567 motif 2; other site 768492002568 motif 3; other site 768492002569 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 768492002570 DHHA1 domain; Region: DHHA1; pfam02272 768492002571 carbon storage regulator; Provisional; Region: PRK01712 768492002572 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 768492002573 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492002574 motif II; other site 768492002575 Predicted membrane protein [Function unknown]; Region: COG1238 768492002576 glutamate--cysteine ligase; Provisional; Region: PRK02107 768492002577 S-ribosylhomocysteinase; Provisional; Region: PRK02260 768492002578 hypothetical protein; Provisional; Region: PRK11573 768492002579 Domain of unknown function DUF21; Region: DUF21; pfam01595 768492002580 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 768492002581 Transporter associated domain; Region: CorC_HlyC; smart01091 768492002582 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 768492002583 signal recognition particle protein; Provisional; Region: PRK10867 768492002584 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 768492002585 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 768492002586 P loop; other site 768492002587 GTP binding site [chemical binding]; other site 768492002588 Signal peptide binding domain; Region: SRP_SPB; pfam02978 768492002589 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 768492002590 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 768492002591 RimM N-terminal domain; Region: RimM; pfam01782 768492002592 PRC-barrel domain; Region: PRC; pfam05239 768492002593 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 768492002594 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 768492002595 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 768492002596 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 768492002597 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 768492002598 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 768492002599 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 768492002600 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 768492002601 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 768492002602 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 768492002603 major tail tube protein; Provisional; Region: FII; PHA02600 768492002604 major tail sheath protein; Provisional; Region: FI; PHA02560 768492002605 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 768492002606 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 768492002607 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 768492002608 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 768492002609 baseplate assembly protein; Provisional; Region: J; PHA02568 768492002610 baseplate wedge subunit; Provisional; Region: W; PHA02516 768492002611 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 768492002612 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 768492002613 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 768492002614 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 768492002615 catalytic residues [active] 768492002616 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 768492002617 DksA-like zinc finger domain containing protein; Region: PHA00080 768492002618 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 768492002619 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 768492002620 Protein of unknown function, DUF481; Region: DUF481; cl01213 768492002621 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 768492002622 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 768492002623 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 768492002624 Chorismate mutase type II; Region: CM_2; cl00693 768492002625 prephenate dehydrogenase; Validated; Region: PRK08507 768492002626 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 768492002627 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 768492002628 Prephenate dehydratase; Region: PDT; pfam00800 768492002629 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 768492002630 putative L-Phe binding site [chemical binding]; other site 768492002631 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 768492002632 30S subunit binding site; other site 768492002633 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 768492002634 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 768492002635 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768492002636 RNA binding surface [nucleotide binding]; other site 768492002637 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 768492002638 active site 768492002639 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 768492002640 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 768492002641 protein disaggregation chaperone; Provisional; Region: PRK10865 768492002642 Clp amino terminal domain; Region: Clp_N; pfam02861 768492002643 Clp amino terminal domain; Region: Clp_N; pfam02861 768492002644 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492002645 Walker A motif; other site 768492002646 ATP binding site [chemical binding]; other site 768492002647 Walker B motif; other site 768492002648 arginine finger; other site 768492002649 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492002650 Walker A motif; other site 768492002651 ATP binding site [chemical binding]; other site 768492002652 Walker B motif; other site 768492002653 arginine finger; other site 768492002654 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 768492002655 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 768492002656 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 768492002657 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 768492002658 putative acyl-acceptor binding pocket; other site 768492002659 Phosphopantetheine attachment site; Region: PP-binding; cl09936 768492002660 acyl carrier protein; Provisional; Region: PRK05350 768492002661 Predicted membrane protein [Function unknown]; Region: COG4648 768492002662 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 768492002663 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 768492002664 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 768492002665 acyl-activating enzyme (AAE) consensus motif; other site 768492002666 acyl-activating enzyme (AAE) consensus motif; other site 768492002667 AMP binding site [chemical binding]; other site 768492002668 active site 768492002669 CoA binding site [chemical binding]; other site 768492002670 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 768492002671 active site 2 [active] 768492002672 active site 1 [active] 768492002673 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 768492002674 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 768492002675 Ligand binding site; other site 768492002676 Putative Catalytic site; other site 768492002677 DXD motif; other site 768492002678 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 768492002679 putative acyl-acceptor binding pocket; other site 768492002680 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 768492002681 active site 768492002682 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 768492002683 Predicted exporter [General function prediction only]; Region: COG4258 768492002684 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 768492002685 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 768492002686 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 768492002687 dimer interface [polypeptide binding]; other site 768492002688 active site 768492002689 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 768492002690 putative active site 1 [active] 768492002691 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 768492002692 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 768492002693 NAD(P) binding site [chemical binding]; other site 768492002694 homotetramer interface [polypeptide binding]; other site 768492002695 homodimer interface [polypeptide binding]; other site 768492002696 active site 768492002697 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 768492002698 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 768492002699 dimer interface [polypeptide binding]; other site 768492002700 active site 768492002701 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768492002702 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768492002703 active site 768492002704 catalytic tetrad [active] 768492002705 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492002706 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492002707 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492002708 dimerization interface [polypeptide binding]; other site 768492002709 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768492002710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492002711 putative substrate translocation pore; other site 768492002712 hypothetical protein; Provisional; Region: PRK05421 768492002713 putative catalytic site [active] 768492002714 putative phosphate binding site [ion binding]; other site 768492002715 putative metal binding site [ion binding]; other site 768492002716 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 768492002717 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768492002718 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768492002719 catalytic residue [active] 768492002720 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768492002721 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768492002722 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 768492002723 Methyltransferase domain; Region: Methyltransf_23; pfam13489 768492002724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492002725 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 768492002726 RNA/DNA hybrid binding site [nucleotide binding]; other site 768492002727 active site 768492002728 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 768492002729 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 768492002730 active site 768492002731 catalytic site [active] 768492002732 substrate binding site [chemical binding]; other site 768492002733 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 768492002734 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 768492002735 Na binding site [ion binding]; other site 768492002736 putative substrate binding site [chemical binding]; other site 768492002737 Transcriptional regulators [Transcription]; Region: FadR; COG2186 768492002738 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492002739 DNA-binding site [nucleotide binding]; DNA binding site 768492002740 FCD domain; Region: FCD; pfam07729 768492002741 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 768492002742 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 768492002743 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 768492002744 active site 768492002745 catalytic site [active] 768492002746 tetramer interface [polypeptide binding]; other site 768492002747 Helix-turn-helix domain; Region: HTH_37; pfam13744 768492002748 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 768492002749 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 768492002750 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768492002751 N-terminal plug; other site 768492002752 ligand-binding site [chemical binding]; other site 768492002753 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 768492002754 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768492002755 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 768492002756 IucA / IucC family; Region: IucA_IucC; pfam04183 768492002757 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 768492002758 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 768492002759 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 768492002760 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 768492002761 IucA / IucC family; Region: IucA_IucC; pfam04183 768492002762 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 768492002763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492002764 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768492002765 putative substrate translocation pore; other site 768492002766 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 768492002767 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 768492002768 FAD binding pocket [chemical binding]; other site 768492002769 FAD binding motif [chemical binding]; other site 768492002770 phosphate binding motif [ion binding]; other site 768492002771 NAD binding pocket [chemical binding]; other site 768492002772 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 768492002773 amidase; Provisional; Region: PRK09201 768492002774 Amidase; Region: Amidase; cl11426 768492002775 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 768492002776 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 768492002777 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 768492002778 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 768492002779 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768492002780 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 768492002781 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768492002782 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492002783 substrate binding pocket [chemical binding]; other site 768492002784 membrane-bound complex binding site; other site 768492002785 hinge residues; other site 768492002786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492002787 dimer interface [polypeptide binding]; other site 768492002788 conserved gate region; other site 768492002789 putative PBP binding loops; other site 768492002790 ABC-ATPase subunit interface; other site 768492002791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 768492002792 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492002793 ABC-ATPase subunit interface; other site 768492002794 putative PBP binding loops; other site 768492002795 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 768492002796 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 768492002797 Walker A/P-loop; other site 768492002798 ATP binding site [chemical binding]; other site 768492002799 Q-loop/lid; other site 768492002800 ABC transporter signature motif; other site 768492002801 Walker B; other site 768492002802 D-loop; other site 768492002803 H-loop/switch region; other site 768492002804 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 768492002805 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492002806 catalytic residue [active] 768492002807 allantoate amidohydrolase; Reviewed; Region: PRK09290 768492002808 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 768492002809 active site 768492002810 metal binding site [ion binding]; metal-binding site 768492002811 dimer interface [polypeptide binding]; other site 768492002812 OHCU decarboxylase; Region: UraD_2; TIGR03180 768492002813 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 768492002814 active site 768492002815 homotetramer interface [polypeptide binding]; other site 768492002816 xanthine permease; Region: pbuX; TIGR03173 768492002817 C-N hydrolase family amidase; Provisional; Region: PRK10438 768492002818 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 768492002819 putative active site [active] 768492002820 catalytic triad [active] 768492002821 dimer interface [polypeptide binding]; other site 768492002822 multimer interface [polypeptide binding]; other site 768492002823 methionine aminotransferase; Validated; Region: PRK09082 768492002824 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492002825 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492002826 homodimer interface [polypeptide binding]; other site 768492002827 catalytic residue [active] 768492002828 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 768492002829 intersubunit interface [polypeptide binding]; other site 768492002830 active site 768492002831 Zn2+ binding site [ion binding]; other site 768492002832 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 768492002833 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 768492002834 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 768492002835 Cupin domain; Region: Cupin_2; cl17218 768492002836 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 768492002837 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 768492002838 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 768492002839 Hok/gef family; Region: HOK_GEF; pfam01848 768492002840 Hok/gef family; Region: HOK_GEF; pfam01848 768492002841 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 768492002842 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 768492002843 active site 768492002844 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 768492002845 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 768492002846 dimer interface [polypeptide binding]; other site 768492002847 active site 768492002848 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 768492002849 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 768492002850 putative active site [active] 768492002851 putative dimer interface [polypeptide binding]; other site 768492002852 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 768492002853 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 768492002854 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768492002855 E3 interaction surface; other site 768492002856 lipoyl attachment site [posttranslational modification]; other site 768492002857 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 768492002858 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 768492002859 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 768492002860 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 768492002861 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 768492002862 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 768492002863 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 768492002864 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768492002865 catalytic loop [active] 768492002866 iron binding site [ion binding]; other site 768492002867 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 768492002868 FAD binding pocket [chemical binding]; other site 768492002869 FAD binding motif [chemical binding]; other site 768492002870 phosphate binding motif [ion binding]; other site 768492002871 beta-alpha-beta structure motif; other site 768492002872 NAD binding pocket [chemical binding]; other site 768492002873 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 768492002874 ApbE family; Region: ApbE; pfam02424 768492002875 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991 768492002876 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 768492002877 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 768492002878 active site 768492002879 catalytic site [active] 768492002880 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 768492002881 active site 768492002882 DNA polymerase IV; Validated; Region: PRK02406 768492002883 DNA binding site [nucleotide binding] 768492002884 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 768492002885 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 768492002886 metal binding site [ion binding]; metal-binding site 768492002887 dimer interface [polypeptide binding]; other site 768492002888 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768492002889 active site 768492002890 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 768492002891 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 768492002892 gamma-glutamyl kinase; Provisional; Region: PRK05429 768492002893 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 768492002894 nucleotide binding site [chemical binding]; other site 768492002895 homotetrameric interface [polypeptide binding]; other site 768492002896 putative phosphate binding site [ion binding]; other site 768492002897 putative allosteric binding site; other site 768492002898 PUA domain; Region: PUA; pfam01472 768492002899 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 768492002900 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 768492002901 putative catalytic cysteine [active] 768492002902 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318 768492002903 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768492002904 Zn2+ binding site [ion binding]; other site 768492002905 Mg2+ binding site [ion binding]; other site 768492002906 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 768492002907 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492002908 non-specific DNA binding site [nucleotide binding]; other site 768492002909 salt bridge; other site 768492002910 sequence-specific DNA binding site [nucleotide binding]; other site 768492002911 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 768492002912 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 768492002913 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 768492002914 peptide binding site [polypeptide binding]; other site 768492002915 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 768492002916 Condensation domain; Region: Condensation; pfam00668 768492002917 Nonribosomal peptide synthase; Region: NRPS; pfam08415 768492002918 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 768492002919 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 768492002920 acyl-activating enzyme (AAE) consensus motif; other site 768492002921 AMP binding site [chemical binding]; other site 768492002922 Condensation domain; Region: Condensation; pfam00668 768492002923 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 768492002924 Nonribosomal peptide synthase; Region: NRPS; pfam08415 768492002925 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 768492002926 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 768492002927 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768492002928 Condensation domain; Region: Condensation; pfam00668 768492002929 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 768492002930 Uncharacterized conserved protein [Function unknown]; Region: COG3391 768492002931 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 768492002932 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 768492002933 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 768492002934 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 768492002935 catalytic residues [active] 768492002936 hinge region; other site 768492002937 alpha helical domain; other site 768492002938 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 768492002939 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492002940 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 768492002941 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 768492002942 NAD(P) binding site [chemical binding]; other site 768492002943 catalytic residues [active] 768492002944 leucine export protein LeuE; Provisional; Region: PRK10958 768492002945 tellurite resistance protein TehB; Provisional; Region: PRK12335 768492002946 Domain of unknown function (DUF1971); Region: DUF1971; cl17717 768492002947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492002948 S-adenosylmethionine binding site [chemical binding]; other site 768492002949 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768492002950 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492002951 Coenzyme A binding pocket [chemical binding]; other site 768492002952 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 768492002953 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 768492002954 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 768492002955 C-terminal domain interface [polypeptide binding]; other site 768492002956 GSH binding site (G-site) [chemical binding]; other site 768492002957 dimer interface [polypeptide binding]; other site 768492002958 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 768492002959 N-terminal domain interface [polypeptide binding]; other site 768492002960 dimer interface [polypeptide binding]; other site 768492002961 substrate binding pocket (H-site) [chemical binding]; other site 768492002962 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768492002963 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 768492002964 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492002965 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492002966 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492002967 dimerization interface [polypeptide binding]; other site 768492002968 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 768492002969 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 768492002970 dimer interface [polypeptide binding]; other site 768492002971 PYR/PP interface [polypeptide binding]; other site 768492002972 TPP binding site [chemical binding]; other site 768492002973 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768492002974 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 768492002975 TPP-binding site [chemical binding]; other site 768492002976 dimer interface [polypeptide binding]; other site 768492002977 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 768492002978 hypothetical protein; Provisional; Region: PRK11667 768492002979 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 768492002980 Domain of unknown function (DUF333); Region: DUF333; pfam03891 768492002981 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 768492002982 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 768492002983 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 768492002984 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 768492002985 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768492002986 active site 768492002987 metal binding site [ion binding]; metal-binding site 768492002988 LysR family transcriptional regulator; Provisional; Region: PRK14997 768492002989 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492002990 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 768492002991 putative effector binding pocket; other site 768492002992 putative dimerization interface [polypeptide binding]; other site 768492002993 Pirin-related protein [General function prediction only]; Region: COG1741 768492002994 Pirin; Region: Pirin; pfam02678 768492002995 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 768492002996 Isochorismatase family; Region: Isochorismatase; pfam00857 768492002997 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 768492002998 catalytic triad [active] 768492002999 dimer interface [polypeptide binding]; other site 768492003000 conserved cis-peptide bond; other site 768492003001 aconitate hydratase, mitochondrial; Region: aconitase_mito; TIGR01340 768492003002 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 768492003003 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768492003004 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768492003005 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 768492003006 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 768492003007 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492003008 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768492003009 salt bridge; other site 768492003010 non-specific DNA binding site [nucleotide binding]; other site 768492003011 sequence-specific DNA binding site [nucleotide binding]; other site 768492003012 Methyltransferase domain; Region: Methyltransf_31; pfam13847 768492003013 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492003014 S-adenosylmethionine binding site [chemical binding]; other site 768492003015 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 768492003016 amphipathic channel; other site 768492003017 Asn-Pro-Ala signature motifs; other site 768492003018 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 768492003019 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 768492003020 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 768492003021 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 768492003022 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492003023 Coenzyme A binding pocket [chemical binding]; other site 768492003024 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 768492003025 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 768492003026 putative ligand binding residues [chemical binding]; other site 768492003027 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768492003028 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492003029 Coenzyme A binding pocket [chemical binding]; other site 768492003030 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 768492003031 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 768492003032 ADP binding site [chemical binding]; other site 768492003033 magnesium binding site [ion binding]; other site 768492003034 putative shikimate binding site; other site 768492003035 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768492003036 active site 768492003037 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768492003038 catalytic tetrad [active] 768492003039 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492003040 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768492003041 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768492003042 Helix-turn-helix domain; Region: HTH_18; pfam12833 768492003043 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492003044 SnoaL-like domain; Region: SnoaL_2; pfam12680 768492003045 hypothetical protein; Provisional; Region: PRK10380 768492003046 hypothetical protein; Provisional; Region: PRK10579 768492003047 recombination associated protein; Reviewed; Region: rdgC; PRK00321 768492003048 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768492003049 dimerization interface [polypeptide binding]; other site 768492003050 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768492003051 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768492003052 putative active site [active] 768492003053 heme pocket [chemical binding]; other site 768492003054 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492003055 dimer interface [polypeptide binding]; other site 768492003056 phosphorylation site [posttranslational modification] 768492003057 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492003058 ATP binding site [chemical binding]; other site 768492003059 Mg2+ binding site [ion binding]; other site 768492003060 G-X-G motif; other site 768492003061 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 768492003062 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492003063 active site 768492003064 phosphorylation site [posttranslational modification] 768492003065 intermolecular recognition site; other site 768492003066 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 768492003067 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768492003068 Walker A/P-loop; other site 768492003069 ATP binding site [chemical binding]; other site 768492003070 Q-loop/lid; other site 768492003071 ABC transporter signature motif; other site 768492003072 Walker B; other site 768492003073 D-loop; other site 768492003074 H-loop/switch region; other site 768492003075 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768492003076 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768492003077 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768492003078 TM-ABC transporter signature motif; other site 768492003079 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 768492003080 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 768492003081 putative ligand binding site [chemical binding]; other site 768492003082 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 768492003083 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 768492003084 intersubunit interface [polypeptide binding]; other site 768492003085 active site 768492003086 zinc binding site [ion binding]; other site 768492003087 Na+ binding site [ion binding]; other site 768492003088 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 768492003089 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768492003090 substrate binding site [chemical binding]; other site 768492003091 ATP binding site [chemical binding]; other site 768492003092 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768492003093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492003094 active site 768492003095 phosphorylation site [posttranslational modification] 768492003096 intermolecular recognition site; other site 768492003097 dimerization interface [polypeptide binding]; other site 768492003098 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768492003099 DNA binding site [nucleotide binding] 768492003100 fructokinase; Reviewed; Region: PRK09557 768492003101 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768492003102 nucleotide binding site [chemical binding]; other site 768492003103 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 768492003104 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 768492003105 putative active site [active] 768492003106 transcriptional antiterminator BglG; Provisional; Region: PRK09772 768492003107 CAT RNA binding domain; Region: CAT_RBD; smart01061 768492003108 PRD domain; Region: PRD; pfam00874 768492003109 PRD domain; Region: PRD; pfam00874 768492003110 ethanolamine permease; Region: 2A0305; TIGR00908 768492003111 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768492003112 AAA domain; Region: AAA_23; pfam13476 768492003113 Walker A/P-loop; other site 768492003114 ATP binding site [chemical binding]; other site 768492003115 Q-loop/lid; other site 768492003116 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768492003117 ABC transporter signature motif; other site 768492003118 Walker B; other site 768492003119 D-loop; other site 768492003120 H-loop/switch region; other site 768492003121 exonuclease subunit SbcD; Provisional; Region: PRK10966 768492003122 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 768492003123 active site 768492003124 metal binding site [ion binding]; metal-binding site 768492003125 DNA binding site [nucleotide binding] 768492003126 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 768492003127 transcriptional regulator PhoB; Provisional; Region: PRK10161 768492003128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492003129 active site 768492003130 phosphorylation site [posttranslational modification] 768492003131 intermolecular recognition site; other site 768492003132 dimerization interface [polypeptide binding]; other site 768492003133 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768492003134 DNA binding site [nucleotide binding] 768492003135 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 768492003136 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 768492003137 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768492003138 putative active site [active] 768492003139 heme pocket [chemical binding]; other site 768492003140 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492003141 dimer interface [polypeptide binding]; other site 768492003142 phosphorylation site [posttranslational modification] 768492003143 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492003144 ATP binding site [chemical binding]; other site 768492003145 Mg2+ binding site [ion binding]; other site 768492003146 G-X-G motif; other site 768492003147 PBP superfamily domain; Region: PBP_like_2; cl17296 768492003148 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 768492003149 substrate binding site [chemical binding]; other site 768492003150 THF binding site; other site 768492003151 zinc-binding site [ion binding]; other site 768492003152 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 768492003153 putative proline-specific permease; Provisional; Region: proY; PRK10580 768492003154 Spore germination protein; Region: Spore_permease; cl17796 768492003155 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 768492003156 Mechanosensitive ion channel; Region: MS_channel; pfam00924 768492003157 maltodextrin glucosidase; Provisional; Region: PRK10785 768492003158 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 768492003159 homodimer interface [polypeptide binding]; other site 768492003160 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 768492003161 active site 768492003162 homodimer interface [polypeptide binding]; other site 768492003163 catalytic site [active] 768492003164 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 768492003165 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 768492003166 peroxidase; Provisional; Region: PRK15000 768492003167 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 768492003168 dimer interface [polypeptide binding]; other site 768492003169 decamer (pentamer of dimers) interface [polypeptide binding]; other site 768492003170 catalytic triad [active] 768492003171 peroxidatic and resolving cysteines [active] 768492003172 Protein of unknown function, DUF479; Region: DUF479; cl01203 768492003173 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 768492003174 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 768492003175 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 768492003176 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 768492003177 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 768492003178 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 768492003179 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 768492003180 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 768492003181 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 768492003182 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 768492003183 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 768492003184 Protein export membrane protein; Region: SecD_SecF; pfam02355 768492003185 hypothetical protein; Provisional; Region: PRK11530 768492003186 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 768492003187 ATP cone domain; Region: ATP-cone; pfam03477 768492003188 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 768492003189 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 768492003190 catalytic motif [active] 768492003191 Zn binding site [ion binding]; other site 768492003192 RibD C-terminal domain; Region: RibD_C; cl17279 768492003193 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 768492003194 homopentamer interface [polypeptide binding]; other site 768492003195 active site 768492003196 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 768492003197 putative RNA binding site [nucleotide binding]; other site 768492003198 thiamine monophosphate kinase; Provisional; Region: PRK05731 768492003199 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 768492003200 ATP binding site [chemical binding]; other site 768492003201 dimerization interface [polypeptide binding]; other site 768492003202 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 768492003203 tetramer interfaces [polypeptide binding]; other site 768492003204 binuclear metal-binding site [ion binding]; other site 768492003205 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768492003206 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768492003207 active site 768492003208 catalytic tetrad [active] 768492003209 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 768492003210 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 768492003211 TPP-binding site; other site 768492003212 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 768492003213 PYR/PP interface [polypeptide binding]; other site 768492003214 dimer interface [polypeptide binding]; other site 768492003215 TPP binding site [chemical binding]; other site 768492003216 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768492003217 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 768492003218 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 768492003219 substrate binding pocket [chemical binding]; other site 768492003220 chain length determination region; other site 768492003221 substrate-Mg2+ binding site; other site 768492003222 catalytic residues [active] 768492003223 aspartate-rich region 1; other site 768492003224 active site lid residues [active] 768492003225 aspartate-rich region 2; other site 768492003226 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 768492003227 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 768492003228 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 768492003229 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 768492003230 Ligand Binding Site [chemical binding]; other site 768492003231 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 768492003232 active site residue [active] 768492003233 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 768492003234 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 768492003235 conserved cys residue [active] 768492003236 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 768492003237 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 768492003238 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 768492003239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 768492003240 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 768492003241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492003242 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768492003243 putative substrate translocation pore; other site 768492003244 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 768492003245 UbiA prenyltransferase family; Region: UbiA; pfam01040 768492003246 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 768492003247 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 768492003248 Subunit I/III interface [polypeptide binding]; other site 768492003249 Subunit III/IV interface [polypeptide binding]; other site 768492003250 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 768492003251 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 768492003252 D-pathway; other site 768492003253 Putative ubiquinol binding site [chemical binding]; other site 768492003254 Low-spin heme (heme b) binding site [chemical binding]; other site 768492003255 Putative water exit pathway; other site 768492003256 Binuclear center (heme o3/CuB) [ion binding]; other site 768492003257 K-pathway; other site 768492003258 Putative proton exit pathway; other site 768492003259 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 768492003260 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 768492003261 Acetyl-coenzyme A transporter 1; Region: Acatn; pfam13000 768492003262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492003263 putative substrate translocation pore; other site 768492003264 hypothetical protein; Provisional; Region: PRK11627 768492003265 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 768492003266 transcriptional regulator BolA; Provisional; Region: PRK11628 768492003267 trigger factor; Provisional; Region: tig; PRK01490 768492003268 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 768492003269 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 768492003270 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 768492003271 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 768492003272 oligomer interface [polypeptide binding]; other site 768492003273 active site residues [active] 768492003274 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 768492003275 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 768492003276 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492003277 Walker A motif; other site 768492003278 ATP binding site [chemical binding]; other site 768492003279 Walker B motif; other site 768492003280 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 768492003281 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 768492003282 Found in ATP-dependent protease La (LON); Region: LON; smart00464 768492003283 Found in ATP-dependent protease La (LON); Region: LON; smart00464 768492003284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492003285 Walker A motif; other site 768492003286 ATP binding site [chemical binding]; other site 768492003287 Walker B motif; other site 768492003288 arginine finger; other site 768492003289 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 768492003290 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 768492003291 IHF dimer interface [polypeptide binding]; other site 768492003292 IHF - DNA interface [nucleotide binding]; other site 768492003293 periplasmic folding chaperone; Provisional; Region: PRK10788 768492003294 SurA N-terminal domain; Region: SurA_N_3; cl07813 768492003295 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 768492003296 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 768492003297 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 768492003298 active site 768492003299 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 768492003300 Ligand Binding Site [chemical binding]; other site 768492003301 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 768492003302 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 768492003303 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 768492003304 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 768492003305 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492003306 active site 768492003307 motif I; other site 768492003308 motif II; other site 768492003309 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 768492003310 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 768492003311 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 768492003312 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492003313 catalytic residue [active] 768492003314 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768492003315 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768492003316 putative DNA binding site [nucleotide binding]; other site 768492003317 putative Zn2+ binding site [ion binding]; other site 768492003318 AsnC family; Region: AsnC_trans_reg; pfam01037 768492003319 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 768492003320 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768492003321 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768492003322 Walker A/P-loop; other site 768492003323 ATP binding site [chemical binding]; other site 768492003324 Q-loop/lid; other site 768492003325 ABC transporter signature motif; other site 768492003326 Walker B; other site 768492003327 D-loop; other site 768492003328 H-loop/switch region; other site 768492003329 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 768492003330 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768492003331 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 768492003332 Walker A/P-loop; other site 768492003333 ATP binding site [chemical binding]; other site 768492003334 Q-loop/lid; other site 768492003335 ABC transporter signature motif; other site 768492003336 Walker B; other site 768492003337 D-loop; other site 768492003338 H-loop/switch region; other site 768492003339 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 768492003340 Nitrogen regulatory protein P-II; Region: P-II; smart00938 768492003341 ammonium transporter; Provisional; Region: PRK10666 768492003342 acyl-CoA thioesterase II; Provisional; Region: PRK10526 768492003343 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 768492003344 active site 768492003345 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 768492003346 catalytic triad [active] 768492003347 dimer interface [polypeptide binding]; other site 768492003348 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 768492003349 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 768492003350 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 768492003351 DNA binding site [nucleotide binding] 768492003352 active site 768492003353 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 768492003354 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768492003355 active site 768492003356 DNA binding site [nucleotide binding] 768492003357 Int/Topo IB signature motif; other site 768492003358 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 768492003359 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768492003360 active site 768492003361 DNA binding site [nucleotide binding] 768492003362 Int/Topo IB signature motif; other site 768492003363 Helix-turn-helix domain; Region: HTH_36; pfam13730 768492003364 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 768492003365 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442 768492003366 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768492003367 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 768492003368 Right handed beta helix region; Region: Beta_helix; pfam13229 768492003369 gene expression modulator; Provisional; Region: PRK10945 768492003370 Hha toxicity attenuator; Provisional; Region: PRK10667 768492003371 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 768492003372 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 768492003373 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 768492003374 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768492003375 ABC-ATPase subunit interface; other site 768492003376 dimer interface [polypeptide binding]; other site 768492003377 putative PBP binding regions; other site 768492003378 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 768492003379 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 768492003380 metal binding site [ion binding]; metal-binding site 768492003381 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 768492003382 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 768492003383 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 768492003384 Protein export membrane protein; Region: SecD_SecF; cl14618 768492003385 Protein export membrane protein; Region: SecD_SecF; cl14618 768492003386 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 768492003387 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768492003388 HlyD family secretion protein; Region: HlyD_3; pfam13437 768492003389 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 768492003390 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768492003391 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 768492003392 DsrE/DsrF-like family; Region: DrsE; cl00672 768492003393 hypothetical protein; Provisional; Region: PRK11281 768492003394 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 768492003395 Mechanosensitive ion channel; Region: MS_channel; pfam00924 768492003396 Protein of unknown function (DUF2496); Region: DUF2496; cl11670 768492003397 Primosomal replication protein priB and priC; Region: priB_priC; pfam07445 768492003398 hypothetical protein; Provisional; Region: PRK10527 768492003399 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768492003400 active site 768492003401 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 768492003402 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492003403 Walker A motif; other site 768492003404 ATP binding site [chemical binding]; other site 768492003405 Walker B motif; other site 768492003406 arginine finger; other site 768492003407 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 768492003408 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 768492003409 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 768492003410 hypothetical protein; Validated; Region: PRK00153 768492003411 recombination protein RecR; Reviewed; Region: recR; PRK00076 768492003412 RecR protein; Region: RecR; pfam02132 768492003413 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 768492003414 putative active site [active] 768492003415 putative metal-binding site [ion binding]; other site 768492003416 tetramer interface [polypeptide binding]; other site 768492003417 heat shock protein 90; Provisional; Region: PRK05218 768492003418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492003419 ATP binding site [chemical binding]; other site 768492003420 Mg2+ binding site [ion binding]; other site 768492003421 G-X-G motif; other site 768492003422 adenylate kinase; Reviewed; Region: adk; PRK00279 768492003423 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 768492003424 AMP-binding site [chemical binding]; other site 768492003425 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 768492003426 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 768492003427 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 768492003428 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 768492003429 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 768492003430 fructuronate transporter; Provisional; Region: PRK10034; cl15264 768492003431 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 768492003432 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 768492003433 ferrochelatase; Reviewed; Region: hemH; PRK00035 768492003434 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 768492003435 C-terminal domain interface [polypeptide binding]; other site 768492003436 active site 768492003437 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 768492003438 active site 768492003439 N-terminal domain interface [polypeptide binding]; other site 768492003440 inosine/guanosine kinase; Provisional; Region: PRK15074 768492003441 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768492003442 substrate binding site [chemical binding]; other site 768492003443 ATP binding site [chemical binding]; other site 768492003444 putative cation:proton antiport protein; Provisional; Region: PRK10669 768492003445 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 768492003446 TrkA-N domain; Region: TrkA_N; pfam02254 768492003447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492003448 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768492003449 putative substrate translocation pore; other site 768492003450 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 768492003451 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 768492003452 active site 768492003453 metal binding site [ion binding]; metal-binding site 768492003454 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 768492003455 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 768492003456 putative deacylase active site [active] 768492003457 TraB family; Region: TraB; cl12050 768492003458 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 768492003459 metal-binding site [ion binding] 768492003460 copper exporting ATPase; Provisional; Region: copA; PRK10671 768492003461 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 768492003462 metal-binding site [ion binding] 768492003463 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 768492003464 metal-binding site [ion binding] 768492003465 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768492003466 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492003467 motif II; other site 768492003468 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 768492003469 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 768492003470 DNA binding residues [nucleotide binding] 768492003471 dimer interface [polypeptide binding]; other site 768492003472 copper binding site [ion binding]; other site 768492003473 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 768492003474 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 768492003475 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 768492003476 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 768492003477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492003478 S-adenosylmethionine binding site [chemical binding]; other site 768492003479 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 768492003480 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 768492003481 oxidoreductase; Provisional; Region: PRK08017 768492003482 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 768492003483 NADP binding site [chemical binding]; other site 768492003484 active site 768492003485 steroid binding site; other site 768492003486 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 768492003487 active site 768492003488 catalytic triad [active] 768492003489 oxyanion hole [active] 768492003490 switch loop; other site 768492003491 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 768492003492 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768492003493 Walker A/P-loop; other site 768492003494 ATP binding site [chemical binding]; other site 768492003495 Q-loop/lid; other site 768492003496 ABC transporter signature motif; other site 768492003497 Walker B; other site 768492003498 D-loop; other site 768492003499 H-loop/switch region; other site 768492003500 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 768492003501 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768492003502 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 768492003503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492003504 putative substrate translocation pore; other site 768492003505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492003506 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 768492003507 ATP-grasp domain; Region: ATP-grasp; pfam02222 768492003508 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 768492003509 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 768492003510 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 768492003511 putative active site [active] 768492003512 putative metal binding site [ion binding]; other site 768492003513 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 768492003514 substrate binding site [chemical binding]; other site 768492003515 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 768492003516 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 768492003517 active site 768492003518 HIGH motif; other site 768492003519 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 768492003520 KMSKS motif; other site 768492003521 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 768492003522 tRNA binding surface [nucleotide binding]; other site 768492003523 anticodon binding site; other site 768492003524 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768492003525 RNA binding surface [nucleotide binding]; other site 768492003526 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 768492003527 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 768492003528 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 768492003529 homodimer interface [polypeptide binding]; other site 768492003530 NADP binding site [chemical binding]; other site 768492003531 substrate binding site [chemical binding]; other site 768492003532 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 768492003533 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 768492003534 Amidohydrolase; Region: Amidohydro_2; pfam04909 768492003535 active site 768492003536 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492003537 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768492003538 Fimbrial protein; Region: Fimbrial; cl01416 768492003539 Fimbrial protein; Region: Fimbrial; cl01416 768492003540 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 768492003541 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 768492003542 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 768492003543 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 768492003544 PapC N-terminal domain; Region: PapC_N; pfam13954 768492003545 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 768492003546 PapC C-terminal domain; Region: PapC_C; pfam13953 768492003547 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 768492003548 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 768492003549 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 768492003550 mannosyl binding site [chemical binding]; other site 768492003551 Fimbrial protein; Region: Fimbrial; pfam00419 768492003552 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 768492003553 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 768492003554 Active Sites [active] 768492003555 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 768492003556 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 768492003557 ParB-like nuclease domain; Region: ParB; smart00470 768492003558 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 768492003559 L-lactate permease; Region: Lactate_perm; cl00701 768492003560 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 768492003561 Cysteine-rich domain; Region: CCG; pfam02754 768492003562 Cysteine-rich domain; Region: CCG; pfam02754 768492003563 iron-sulfur cluster-binding protein; Region: TIGR00273 768492003564 HsdM N-terminal domain; Region: HsdM_N; pfam12161 768492003565 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 768492003566 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768492003567 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 768492003568 Uncharacterized conserved protein [Function unknown]; Region: COG1556 768492003569 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 768492003570 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492003571 active site 768492003572 phosphorylation site [posttranslational modification] 768492003573 intermolecular recognition site; other site 768492003574 dimerization interface [polypeptide binding]; other site 768492003575 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492003576 Walker A motif; other site 768492003577 ATP binding site [chemical binding]; other site 768492003578 Walker B motif; other site 768492003579 arginine finger; other site 768492003580 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768492003581 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768492003582 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492003583 phosphorylation site [posttranslational modification] 768492003584 dimer interface [polypeptide binding]; other site 768492003585 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492003586 ATP binding site [chemical binding]; other site 768492003587 Mg2+ binding site [ion binding]; other site 768492003588 G-X-G motif; other site 768492003589 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 768492003590 conserved cys residue [active] 768492003591 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768492003592 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492003593 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492003594 3-oxoacyl-acyl carrier protein synthase; Provisional; Region: PTZ00050 768492003595 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 768492003596 active site 768492003597 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 768492003598 acyl-CoA synthetase; Validated; Region: PRK05850 768492003599 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 768492003600 acyl-activating enzyme (AAE) consensus motif; other site 768492003601 active site 768492003602 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 768492003603 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 768492003604 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 768492003605 active site 768492003606 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 768492003607 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768492003608 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 768492003609 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768492003610 inhibitor-cofactor binding pocket; inhibition site 768492003611 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492003612 catalytic residue [active] 768492003613 Condensation domain; Region: Condensation; pfam00668 768492003614 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 768492003615 Arylesterase; Region: Arylesterase; pfam01731 768492003616 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768492003617 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 768492003618 catalytic loop [active] 768492003619 iron binding site [ion binding]; other site 768492003620 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 768492003621 FAD binding pocket [chemical binding]; other site 768492003622 conserved FAD binding motif [chemical binding]; other site 768492003623 phosphate binding motif [ion binding]; other site 768492003624 beta-alpha-beta structure motif; other site 768492003625 NAD binding pocket [chemical binding]; other site 768492003626 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 768492003627 Fatty acid desaturase; Region: FA_desaturase; pfam00487 768492003628 putative di-iron ligands [ion binding]; other site 768492003629 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 768492003630 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768492003631 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 768492003632 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 768492003633 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 768492003634 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 768492003635 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768492003636 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768492003637 active site 768492003638 catalytic tetrad [active] 768492003639 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492003640 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492003641 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 768492003642 putative effector binding pocket; other site 768492003643 putative dimerization interface [polypeptide binding]; other site 768492003644 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 768492003645 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768492003646 MASE1; Region: MASE1; cl17823 768492003647 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768492003648 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768492003649 metal binding site [ion binding]; metal-binding site 768492003650 active site 768492003651 I-site; other site 768492003652 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768492003653 DNA-binding site [nucleotide binding]; DNA binding site 768492003654 RNA-binding motif; other site 768492003655 The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6, and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348 768492003656 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768492003657 putative active site [active] 768492003658 putative metal binding site [ion binding]; other site 768492003659 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 768492003660 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768492003661 Walker A/P-loop; other site 768492003662 ATP binding site [chemical binding]; other site 768492003663 Q-loop/lid; other site 768492003664 ABC transporter signature motif; other site 768492003665 Walker B; other site 768492003666 D-loop; other site 768492003667 H-loop/switch region; other site 768492003668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492003669 dimer interface [polypeptide binding]; other site 768492003670 conserved gate region; other site 768492003671 putative PBP binding loops; other site 768492003672 ABC-ATPase subunit interface; other site 768492003673 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768492003674 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492003675 Coenzyme A binding pocket [chemical binding]; other site 768492003676 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 768492003677 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 768492003678 active site 768492003679 non-prolyl cis peptide bond; other site 768492003680 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 768492003681 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 768492003682 metal binding site [ion binding]; metal-binding site 768492003683 dimer interface [polypeptide binding]; other site 768492003684 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768492003685 DNA-binding site [nucleotide binding]; DNA binding site 768492003686 RNA-binding motif; other site 768492003687 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 768492003688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492003689 putative substrate translocation pore; other site 768492003690 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492003691 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768492003692 chromosome condensation membrane protein; Provisional; Region: PRK14196 768492003693 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768492003694 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492003695 Coenzyme A binding pocket [chemical binding]; other site 768492003696 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 768492003697 MASE2 domain; Region: MASE2; pfam05230 768492003698 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768492003699 metal binding site [ion binding]; metal-binding site 768492003700 active site 768492003701 I-site; other site 768492003702 twin arginine translocase protein A; Validated; Region: tatE; PRK01614 768492003703 lipoyl synthase; Provisional; Region: PRK05481 768492003704 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768492003705 FeS/SAM binding site; other site 768492003706 lipoate-protein ligase B; Provisional; Region: PRK14342 768492003707 hypothetical protein; Provisional; Region: PRK04998 768492003708 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 768492003709 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 768492003710 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 768492003711 rare lipoprotein A; Provisional; Region: PRK10672 768492003712 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 768492003713 Sporulation related domain; Region: SPOR; cl10051 768492003714 cell wall shape-determining protein; Provisional; Region: PRK10794 768492003715 penicillin-binding protein 2; Provisional; Region: PRK10795 768492003716 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 768492003717 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 768492003718 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 768492003719 Oligomerisation domain; Region: Oligomerisation; cl00519 768492003720 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 768492003721 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 768492003722 active site 768492003723 (T/H)XGH motif; other site 768492003724 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 768492003725 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 768492003726 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 768492003727 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 768492003728 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 768492003729 HIGH motif; other site 768492003730 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 768492003731 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768492003732 active site 768492003733 KMSKS motif; other site 768492003734 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 768492003735 tRNA binding surface [nucleotide binding]; other site 768492003736 hypothetical protein; Provisional; Region: PRK11032 768492003737 Predicted integral membrane metal-binding protein (DUF2296); Region: DUF2296; pfam10058 768492003738 azoreductase; Reviewed; Region: PRK00170 768492003739 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768492003740 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 768492003741 active site 768492003742 tetramer interface [polypeptide binding]; other site 768492003743 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 768492003744 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 768492003745 Walker A/P-loop; other site 768492003746 ATP binding site [chemical binding]; other site 768492003747 Q-loop/lid; other site 768492003748 ABC transporter signature motif; other site 768492003749 Walker B; other site 768492003750 D-loop; other site 768492003751 H-loop/switch region; other site 768492003752 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768492003753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492003754 dimer interface [polypeptide binding]; other site 768492003755 conserved gate region; other site 768492003756 putative PBP binding loops; other site 768492003757 ABC-ATPase subunit interface; other site 768492003758 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768492003759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492003760 dimer interface [polypeptide binding]; other site 768492003761 conserved gate region; other site 768492003762 putative PBP binding loops; other site 768492003763 ABC-ATPase subunit interface; other site 768492003764 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 768492003765 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492003766 substrate binding pocket [chemical binding]; other site 768492003767 membrane-bound complex binding site; other site 768492003768 hinge residues; other site 768492003769 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 768492003770 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 768492003771 putative active site [active] 768492003772 catalytic triad [active] 768492003773 putative dimer interface [polypeptide binding]; other site 768492003774 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 768492003775 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 768492003776 Transporter associated domain; Region: CorC_HlyC; smart01091 768492003777 metal-binding heat shock protein; Provisional; Region: PRK00016 768492003778 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 768492003779 PhoH-like protein; Region: PhoH; pfam02562 768492003780 hypothetical protein; Provisional; Region: PRK10220 768492003781 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 768492003782 PhnA protein; Region: PhnA; pfam03831 768492003783 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 768492003784 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 768492003785 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768492003786 FeS/SAM binding site; other site 768492003787 TRAM domain; Region: TRAM; pfam01938 768492003788 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 768492003789 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 768492003790 asparagine synthetase B; Provisional; Region: asnB; PRK09431 768492003791 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 768492003792 active site 768492003793 dimer interface [polypeptide binding]; other site 768492003794 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 768492003795 Ligand Binding Site [chemical binding]; other site 768492003796 Molecular Tunnel; other site 768492003797 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 768492003798 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 768492003799 putative active site [active] 768492003800 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 768492003801 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 768492003802 UMP phosphatase; Provisional; Region: PRK10444 768492003803 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492003804 active site 768492003805 motif I; other site 768492003806 motif II; other site 768492003807 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492003808 MarR family; Region: MarR; pfam01047 768492003809 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 768492003810 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768492003811 nucleotide binding site [chemical binding]; other site 768492003812 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 768492003813 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 768492003814 active site 768492003815 dimer interface [polypeptide binding]; other site 768492003816 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 768492003817 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 768492003818 active site 768492003819 trimer interface [polypeptide binding]; other site 768492003820 allosteric site; other site 768492003821 active site lid [active] 768492003822 hexamer (dimer of trimers) interface [polypeptide binding]; other site 768492003823 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 768492003824 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768492003825 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768492003826 active site turn [active] 768492003827 phosphorylation site [posttranslational modification] 768492003828 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 768492003829 HPr interaction site; other site 768492003830 glycerol kinase (GK) interaction site [polypeptide binding]; other site 768492003831 active site 768492003832 phosphorylation site [posttranslational modification] 768492003833 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 768492003834 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768492003835 active site 768492003836 HIGH motif; other site 768492003837 nucleotide binding site [chemical binding]; other site 768492003838 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 768492003839 KMSKS motif; other site 768492003840 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 768492003841 outer membrane porin, OprD family; Region: OprD; pfam03573 768492003842 YbfN-like lipoprotein; Region: YbfN; pfam13982 768492003843 Putative carbohydrate binding domain; Region: CHB_HEX; smart01081 768492003844 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 768492003845 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 768492003846 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a...; Region: GH20_Sm-chitobiase-like; cd06569 768492003847 active site 768492003848 C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847 768492003849 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492003850 sugar efflux transporter; Region: 2A0120; TIGR00899 768492003851 putative substrate translocation pore; other site 768492003852 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 768492003853 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 768492003854 NAD binding site [chemical binding]; other site 768492003855 homodimer interface [polypeptide binding]; other site 768492003856 active site 768492003857 substrate binding site [chemical binding]; other site 768492003858 TcdB toxin N-terminal helical domain; Region: TcdB_N; pfam12918 768492003859 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 768492003860 ferric uptake regulator; Provisional; Region: fur; PRK09462 768492003861 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 768492003862 metal binding site 2 [ion binding]; metal-binding site 768492003863 putative DNA binding helix; other site 768492003864 metal binding site 1 [ion binding]; metal-binding site 768492003865 dimer interface [polypeptide binding]; other site 768492003866 structural Zn2+ binding site [ion binding]; other site 768492003867 flavodoxin FldA; Validated; Region: PRK09267 768492003868 LexA regulated protein; Provisional; Region: PRK11675 768492003869 acyl-CoA esterase; Provisional; Region: PRK10673 768492003870 PGAP1-like protein; Region: PGAP1; pfam07819 768492003871 replication initiation regulator SeqA; Provisional; Region: PRK11187 768492003872 phosphoglucomutase; Validated; Region: PRK07564 768492003873 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 768492003874 active site 768492003875 substrate binding site [chemical binding]; other site 768492003876 metal binding site [ion binding]; metal-binding site 768492003877 Predicted transcriptional regulators [Transcription]; Region: COG1695 768492003878 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 768492003879 Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977 768492003880 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 768492003881 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492003882 active site 768492003883 phosphorylation site [posttranslational modification] 768492003884 intermolecular recognition site; other site 768492003885 dimerization interface [polypeptide binding]; other site 768492003886 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768492003887 DNA binding site [nucleotide binding] 768492003888 sensor protein KdpD; Provisional; Region: PRK10490 768492003889 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 768492003890 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 768492003891 Ligand Binding Site [chemical binding]; other site 768492003892 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 768492003893 GAF domain; Region: GAF_3; pfam13492 768492003894 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492003895 dimer interface [polypeptide binding]; other site 768492003896 phosphorylation site [posttranslational modification] 768492003897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492003898 ATP binding site [chemical binding]; other site 768492003899 Mg2+ binding site [ion binding]; other site 768492003900 G-X-G motif; other site 768492003901 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 768492003902 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 768492003903 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768492003904 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 768492003905 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 768492003906 Protein of unknown function (DUF523); Region: DUF523; pfam04463 768492003907 Uncharacterized conserved protein [Function unknown]; Region: COG3272 768492003908 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 768492003909 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 768492003910 DNA photolyase; Region: DNA_photolyase; pfam00875 768492003911 cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776 768492003912 Uncharacterized conserved protein [Function unknown]; Region: COG0327 768492003913 metal-binding protein; Provisional; Region: PRK10799 768492003914 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 768492003915 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 768492003916 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 768492003917 LamB/YcsF family protein; Provisional; Region: PRK05406 768492003918 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 768492003919 putative substrate binding pocket [chemical binding]; other site 768492003920 AC domain interface; other site 768492003921 catalytic triad [active] 768492003922 AB domain interface; other site 768492003923 interchain disulfide; other site 768492003924 endonuclease VIII; Provisional; Region: PRK10445 768492003925 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 768492003926 DNA binding site [nucleotide binding] 768492003927 catalytic residue [active] 768492003928 H2TH interface [polypeptide binding]; other site 768492003929 putative catalytic residues [active] 768492003930 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 768492003931 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 768492003932 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 768492003933 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 768492003934 dimer interface [polypeptide binding]; other site 768492003935 active site 768492003936 citrylCoA binding site [chemical binding]; other site 768492003937 NADH binding [chemical binding]; other site 768492003938 cationic pore residues; other site 768492003939 oxalacetate/citrate binding site [chemical binding]; other site 768492003940 coenzyme A binding site [chemical binding]; other site 768492003941 catalytic triad [active] 768492003942 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 768492003943 Iron-sulfur protein interface; other site 768492003944 proximal quinone binding site [chemical binding]; other site 768492003945 SdhD (CybS) interface [polypeptide binding]; other site 768492003946 proximal heme binding site [chemical binding]; other site 768492003947 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 768492003948 SdhC subunit interface [polypeptide binding]; other site 768492003949 proximal heme binding site [chemical binding]; other site 768492003950 cardiolipin binding site; other site 768492003951 Iron-sulfur protein interface; other site 768492003952 proximal quinone binding site [chemical binding]; other site 768492003953 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 768492003954 L-aspartate oxidase; Provisional; Region: PRK06175 768492003955 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 768492003956 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 768492003957 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 768492003958 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 768492003959 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 768492003960 TPP-binding site [chemical binding]; other site 768492003961 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 768492003962 dimer interface [polypeptide binding]; other site 768492003963 PYR/PP interface [polypeptide binding]; other site 768492003964 TPP binding site [chemical binding]; other site 768492003965 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 768492003966 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768492003967 E3 interaction surface; other site 768492003968 lipoyl attachment site [posttranslational modification]; other site 768492003969 e3 binding domain; Region: E3_binding; pfam02817 768492003970 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 768492003971 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 768492003972 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 768492003973 CoA-ligase; Region: Ligase_CoA; pfam00549 768492003974 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 768492003975 CoA binding domain; Region: CoA_binding; smart00881 768492003976 CoA-ligase; Region: Ligase_CoA; pfam00549 768492003977 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 768492003978 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 768492003979 active site 768492003980 metal binding site [ion binding]; metal-binding site 768492003981 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 768492003982 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 768492003983 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 768492003984 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 768492003985 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 768492003986 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 768492003987 hypothetical protein; Provisional; Region: PRK10588 768492003988 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 768492003989 active site 768492003990 colicin uptake protein TolQ; Provisional; Region: PRK10801 768492003991 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 768492003992 colicin uptake protein TolR; Provisional; Region: PRK11024 768492003993 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 768492003994 TolA C-terminal; Region: TolA; pfam06519 768492003995 translocation protein TolB; Provisional; Region: tolB; PRK03629 768492003996 TolB amino-terminal domain; Region: TolB_N; pfam04052 768492003997 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 768492003998 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 768492003999 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 768492004000 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 768492004001 Serglycin; Region: Serglycin; pfam04360 768492004002 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 768492004003 ligand binding site [chemical binding]; other site 768492004004 tol-pal system protein YbgF; Provisional; Region: PRK10803 768492004005 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768492004006 binding surface 768492004007 TPR motif; other site 768492004008 quinolinate synthetase; Provisional; Region: PRK09375 768492004009 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 768492004010 zinc transporter ZitB; Provisional; Region: PRK03557 768492004011 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768492004012 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492004013 substrate binding pocket [chemical binding]; other site 768492004014 membrane-bound complex binding site; other site 768492004015 hinge residues; other site 768492004016 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768492004017 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492004018 substrate binding pocket [chemical binding]; other site 768492004019 membrane-bound complex binding site; other site 768492004020 hinge residues; other site 768492004021 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768492004022 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492004023 dimer interface [polypeptide binding]; other site 768492004024 phosphorylation site [posttranslational modification] 768492004025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492004026 ATP binding site [chemical binding]; other site 768492004027 Mg2+ binding site [ion binding]; other site 768492004028 G-X-G motif; other site 768492004029 Response regulator receiver domain; Region: Response_reg; pfam00072 768492004030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492004031 active site 768492004032 phosphorylation site [posttranslational modification] 768492004033 intermolecular recognition site; other site 768492004034 dimerization interface [polypeptide binding]; other site 768492004035 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 768492004036 putative binding surface; other site 768492004037 active site 768492004038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492004039 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768492004040 active site 768492004041 phosphorylation site [posttranslational modification] 768492004042 intermolecular recognition site; other site 768492004043 dimerization interface [polypeptide binding]; other site 768492004044 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492004045 DNA binding residues [nucleotide binding] 768492004046 dimerization interface [polypeptide binding]; other site 768492004047 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 768492004048 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 768492004049 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768492004050 catalytic core [active] 768492004051 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768492004052 psiF repeat; Region: PsiF_repeat; pfam07769 768492004053 psiF repeat; Region: PsiF_repeat; pfam07769 768492004054 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 768492004055 active site 768492004056 catalytic residues [active] 768492004057 galactokinase; Provisional; Region: PRK05101 768492004058 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 768492004059 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 768492004060 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 768492004061 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 768492004062 dimer interface [polypeptide binding]; other site 768492004063 active site 768492004064 CAAX protease self-immunity; Region: Abi; pfam02517 768492004065 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 768492004066 Isochorismatase family; Region: Isochorismatase; pfam00857 768492004067 catalytic triad [active] 768492004068 conserved cis-peptide bond; other site 768492004069 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 768492004070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768492004071 Walker A/P-loop; other site 768492004072 ATP binding site [chemical binding]; other site 768492004073 Q-loop/lid; other site 768492004074 ABC transporter signature motif; other site 768492004075 Walker B; other site 768492004076 D-loop; other site 768492004077 H-loop/switch region; other site 768492004078 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768492004079 Walker A/P-loop; other site 768492004080 ATP binding site [chemical binding]; other site 768492004081 Q-loop/lid; other site 768492004082 ABC transporter signature motif; other site 768492004083 Walker B; other site 768492004084 D-loop; other site 768492004085 H-loop/switch region; other site 768492004086 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 768492004087 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 768492004088 molybdenum-pterin binding domain; Region: Mop; TIGR00638 768492004089 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 768492004090 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 768492004091 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 768492004092 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 768492004093 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 768492004094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492004095 dimer interface [polypeptide binding]; other site 768492004096 conserved gate region; other site 768492004097 putative PBP binding loops; other site 768492004098 ABC-ATPase subunit interface; other site 768492004099 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 768492004100 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768492004101 Walker A/P-loop; other site 768492004102 ATP binding site [chemical binding]; other site 768492004103 Q-loop/lid; other site 768492004104 ABC transporter signature motif; other site 768492004105 Walker B; other site 768492004106 D-loop; other site 768492004107 H-loop/switch region; other site 768492004108 molybdenum-pterin binding domain; Region: Mop; TIGR00638 768492004109 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 768492004110 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492004111 active site 768492004112 motif I; other site 768492004113 motif II; other site 768492004114 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492004115 6-phosphogluconolactonase; Provisional; Region: PRK11028 768492004116 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 768492004117 substrate binding site [chemical binding]; other site 768492004118 Uncharacterized conserved protein [Function unknown]; Region: COG3339 768492004119 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 768492004120 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768492004121 inhibitor-cofactor binding pocket; inhibition site 768492004122 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492004123 catalytic residue [active] 768492004124 biotin synthase; Provisional; Region: PRK15108 768492004125 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768492004126 FeS/SAM binding site; other site 768492004127 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 768492004128 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 768492004129 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 768492004130 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492004131 catalytic residue [active] 768492004132 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 768492004133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492004134 S-adenosylmethionine binding site [chemical binding]; other site 768492004135 AAA domain; Region: AAA_26; pfam13500 768492004136 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 768492004137 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 768492004138 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 768492004139 Walker A/P-loop; other site 768492004140 ATP binding site [chemical binding]; other site 768492004141 Q-loop/lid; other site 768492004142 ABC transporter signature motif; other site 768492004143 Walker B; other site 768492004144 D-loop; other site 768492004145 H-loop/switch region; other site 768492004146 excinuclease ABC subunit B; Provisional; Region: PRK05298 768492004147 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768492004148 ATP binding site [chemical binding]; other site 768492004149 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768492004150 nucleotide binding region [chemical binding]; other site 768492004151 ATP-binding site [chemical binding]; other site 768492004152 Ultra-violet resistance protein B; Region: UvrB; pfam12344 768492004153 UvrB/uvrC motif; Region: UVR; pfam02151 768492004154 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 768492004155 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 768492004156 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 768492004157 phosphate binding site [ion binding]; other site 768492004158 putative substrate binding pocket [chemical binding]; other site 768492004159 dimer interface [polypeptide binding]; other site 768492004160 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 768492004161 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768492004162 FeS/SAM binding site; other site 768492004163 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 768492004164 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 768492004165 MPT binding site; other site 768492004166 trimer interface [polypeptide binding]; other site 768492004167 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 768492004168 trimer interface [polypeptide binding]; other site 768492004169 dimer interface [polypeptide binding]; other site 768492004170 putative active site [active] 768492004171 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 768492004172 MoaE interaction surface [polypeptide binding]; other site 768492004173 MoeB interaction surface [polypeptide binding]; other site 768492004174 thiocarboxylated glycine; other site 768492004175 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 768492004176 MoaE homodimer interface [polypeptide binding]; other site 768492004177 MoaD interaction [polypeptide binding]; other site 768492004178 active site residues [active] 768492004179 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 768492004180 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 768492004181 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 768492004182 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 768492004183 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 768492004184 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 768492004185 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 768492004186 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 768492004187 Walker A/P-loop; other site 768492004188 ATP binding site [chemical binding]; other site 768492004189 Q-loop/lid; other site 768492004190 ABC transporter signature motif; other site 768492004191 Walker B; other site 768492004192 D-loop; other site 768492004193 H-loop/switch region; other site 768492004194 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 768492004195 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 768492004196 Walker A/P-loop; other site 768492004197 ATP binding site [chemical binding]; other site 768492004198 Q-loop/lid; other site 768492004199 ABC transporter signature motif; other site 768492004200 Walker B; other site 768492004201 D-loop; other site 768492004202 H-loop/switch region; other site 768492004203 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 768492004204 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768492004205 HlyD family secretion protein; Region: HlyD_3; pfam13437 768492004206 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 768492004207 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768492004208 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 768492004209 helicase 45; Provisional; Region: PTZ00424 768492004210 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 768492004211 ATP binding site [chemical binding]; other site 768492004212 Mg++ binding site [ion binding]; other site 768492004213 motif III; other site 768492004214 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768492004215 nucleotide binding region [chemical binding]; other site 768492004216 ATP-binding site [chemical binding]; other site 768492004217 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 768492004218 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 768492004219 dimerization interface [polypeptide binding]; other site 768492004220 NAD binding site [chemical binding]; other site 768492004221 ligand binding site [chemical binding]; other site 768492004222 catalytic site [active] 768492004223 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 768492004224 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 768492004225 FMN binding site [chemical binding]; other site 768492004226 active site 768492004227 catalytic residues [active] 768492004228 substrate binding site [chemical binding]; other site 768492004229 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 768492004230 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492004231 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492004232 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492004233 dimerization interface [polypeptide binding]; other site 768492004234 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 768492004235 HD domain; Region: HD_4; pfam13328 768492004236 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 768492004237 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 768492004238 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 768492004239 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768492004240 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492004241 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 768492004242 dimerization interface [polypeptide binding]; other site 768492004243 substrate binding pocket [chemical binding]; other site 768492004244 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 768492004245 L-asparagine permease; Provisional; Region: PRK15049 768492004246 Predicted membrane protein [Function unknown]; Region: COG4125 768492004247 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 768492004248 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 768492004249 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492004250 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492004251 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768492004252 dimerization interface [polypeptide binding]; other site 768492004253 LysE type translocator; Region: LysE; cl00565 768492004254 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 768492004255 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 768492004256 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 768492004257 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 768492004258 conserved cys residue [active] 768492004259 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 768492004260 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 768492004261 conserved cys residue [active] 768492004262 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492004263 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492004264 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 768492004265 NAD binding site [chemical binding]; other site 768492004266 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 768492004267 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 768492004268 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492004269 Coenzyme A binding pocket [chemical binding]; other site 768492004270 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 768492004271 dimer interface [polypeptide binding]; other site 768492004272 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768492004273 Protein of unknown function (DUF808); Region: DUF808; pfam05661 768492004274 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 768492004275 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492004276 Coenzyme A binding pocket [chemical binding]; other site 768492004277 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768492004278 EamA-like transporter family; Region: EamA; pfam00892 768492004279 EamA-like transporter family; Region: EamA; pfam00892 768492004280 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492004281 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492004282 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492004283 dimerization interface [polypeptide binding]; other site 768492004284 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 768492004285 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 768492004286 DNA binding residues [nucleotide binding] 768492004287 putative dimer interface [polypeptide binding]; other site 768492004288 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 768492004289 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 768492004290 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 768492004291 lipoprotein, YaeC family; Region: TIGR00363 768492004292 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 768492004293 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492004294 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768492004295 Coenzyme A binding pocket [chemical binding]; other site 768492004296 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 768492004297 putative trimer interface [polypeptide binding]; other site 768492004298 putative active site [active] 768492004299 putative substrate binding site [chemical binding]; other site 768492004300 putative CoA binding site [chemical binding]; other site 768492004301 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 768492004302 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 768492004303 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 768492004304 NAD(P) binding site [chemical binding]; other site 768492004305 catalytic residues [active] 768492004306 D-lactate dehydrogenase; Provisional; Region: PRK11183 768492004307 FAD binding domain; Region: FAD_binding_4; pfam01565 768492004308 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 768492004309 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 768492004310 active site 768492004311 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 768492004312 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 768492004313 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 768492004314 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 768492004315 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 768492004316 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492004317 substrate binding pocket [chemical binding]; other site 768492004318 membrane-bound complex binding site; other site 768492004319 hinge residues; other site 768492004320 putative aminotransferase; Provisional; Region: PRK12414 768492004321 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492004322 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492004323 homodimer interface [polypeptide binding]; other site 768492004324 catalytic residue [active] 768492004325 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768492004326 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492004327 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 768492004328 dimerization interface [polypeptide binding]; other site 768492004329 substrate binding pocket [chemical binding]; other site 768492004330 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 768492004331 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 768492004332 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 768492004333 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 768492004334 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492004335 DNA-binding site [nucleotide binding]; DNA binding site 768492004336 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 768492004337 Uncharacterized protein conserved in archaea (DUF2099); Region: DUF2099; cl01645 768492004338 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 768492004339 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 768492004340 putative ligand binding residues [chemical binding]; other site 768492004341 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 768492004342 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768492004343 ABC-ATPase subunit interface; other site 768492004344 dimer interface [polypeptide binding]; other site 768492004345 putative PBP binding regions; other site 768492004346 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 768492004347 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768492004348 Walker A/P-loop; other site 768492004349 ATP binding site [chemical binding]; other site 768492004350 Q-loop/lid; other site 768492004351 ABC transporter signature motif; other site 768492004352 Walker B; other site 768492004353 D-loop; other site 768492004354 H-loop/switch region; other site 768492004355 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 768492004356 molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537 768492004357 ParA-like protein; Provisional; Region: PHA02518 768492004358 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 768492004359 P-loop; other site 768492004360 Magnesium ion binding site [ion binding]; other site 768492004361 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 768492004362 active site 768492004363 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492004364 Coenzyme A binding pocket [chemical binding]; other site 768492004365 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492004366 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492004367 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 768492004368 putative effector binding pocket; other site 768492004369 putative dimerization interface [polypeptide binding]; other site 768492004370 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768492004371 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 768492004372 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 768492004373 putative N- and C-terminal domain interface [polypeptide binding]; other site 768492004374 putative active site [active] 768492004375 putative MgATP binding site [chemical binding]; other site 768492004376 catalytic site [active] 768492004377 metal binding site [ion binding]; metal-binding site 768492004378 putative carbohydrate binding site [chemical binding]; other site 768492004379 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 768492004380 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 768492004381 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768492004382 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492004383 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768492004384 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492004385 Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718 768492004386 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 768492004387 ATP binding site [chemical binding]; other site 768492004388 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 768492004389 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 768492004390 active site 768492004391 Na/Ca binding site [ion binding]; other site 768492004392 catalytic site [active] 768492004393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4380 768492004394 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 768492004395 Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462 768492004396 diaminopimelate epimerase; Provisional; Region: PRK13577 768492004397 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 768492004398 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 768492004399 putative transposase OrfB; Reviewed; Region: PHA02517 768492004400 Integrase core domain; Region: rve; pfam00665 768492004401 Integrase core domain; Region: rve_3; pfam13683 768492004402 Homeodomain-like domain; Region: HTH_23; cl17451 768492004403 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 768492004404 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 768492004405 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492004406 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768492004407 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 768492004408 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 768492004409 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492004410 dimer interface [polypeptide binding]; other site 768492004411 conserved gate region; other site 768492004412 putative PBP binding loops; other site 768492004413 ABC-ATPase subunit interface; other site 768492004414 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 768492004415 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 768492004416 Walker A/P-loop; other site 768492004417 ATP binding site [chemical binding]; other site 768492004418 Q-loop/lid; other site 768492004419 ABC transporter signature motif; other site 768492004420 Walker B; other site 768492004421 D-loop; other site 768492004422 H-loop/switch region; other site 768492004423 NIL domain; Region: NIL; pfam09383 768492004424 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768492004425 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492004426 Coenzyme A binding pocket [chemical binding]; other site 768492004427 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492004428 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492004429 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 768492004430 putative effector binding pocket; other site 768492004431 putative dimerization interface [polypeptide binding]; other site 768492004432 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 768492004433 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 768492004434 NADP binding site [chemical binding]; other site 768492004435 dimer interface [polypeptide binding]; other site 768492004436 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 768492004437 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 768492004438 Isochorismatase family; Region: Isochorismatase; pfam00857 768492004439 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 768492004440 catalytic triad [active] 768492004441 conserved cis-peptide bond; other site 768492004442 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492004443 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 768492004444 NAD(P) binding site [chemical binding]; other site 768492004445 active site 768492004446 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 768492004447 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492004448 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 768492004449 dimerization interface [polypeptide binding]; other site 768492004450 substrate binding pocket [chemical binding]; other site 768492004451 Predicted transcriptional regulator [Transcription]; Region: COG2378 768492004452 HTH domain; Region: HTH_11; pfam08279 768492004453 WYL domain; Region: WYL; pfam13280 768492004454 D-galactonate transporter; Region: 2A0114; TIGR00893 768492004455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492004456 putative substrate translocation pore; other site 768492004457 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492004458 DNA-binding site [nucleotide binding]; DNA binding site 768492004459 Transcriptional regulators [Transcription]; Region: GntR; COG1802 768492004460 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 768492004461 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 768492004462 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 768492004463 putative NAD(P) binding site [chemical binding]; other site 768492004464 catalytic Zn binding site [ion binding]; other site 768492004465 structural Zn binding site [ion binding]; other site 768492004466 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 768492004467 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 768492004468 Walker A/P-loop; other site 768492004469 ATP binding site [chemical binding]; other site 768492004470 Q-loop/lid; other site 768492004471 ABC transporter signature motif; other site 768492004472 Walker B; other site 768492004473 D-loop; other site 768492004474 H-loop/switch region; other site 768492004475 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 768492004476 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 768492004477 substrate binding pocket [chemical binding]; other site 768492004478 membrane-bound complex binding site; other site 768492004479 hinge residues; other site 768492004480 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 768492004481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492004482 dimer interface [polypeptide binding]; other site 768492004483 conserved gate region; other site 768492004484 putative PBP binding loops; other site 768492004485 ABC-ATPase subunit interface; other site 768492004486 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 768492004487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492004488 dimer interface [polypeptide binding]; other site 768492004489 conserved gate region; other site 768492004490 putative PBP binding loops; other site 768492004491 ABC-ATPase subunit interface; other site 768492004492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 768492004493 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 768492004494 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 768492004495 allophanate hydrolase; Provisional; Region: PRK08186 768492004496 Amidase; Region: Amidase; cl11426 768492004497 urea carboxylase; Region: urea_carbox; TIGR02712 768492004498 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 768492004499 ATP-grasp domain; Region: ATP-grasp_4; cl17255 768492004500 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 768492004501 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 768492004502 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 768492004503 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 768492004504 carboxyltransferase (CT) interaction site; other site 768492004505 biotinylation site [posttranslational modification]; other site 768492004506 Transcriptional regulators [Transcription]; Region: GntR; COG1802 768492004507 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492004508 DNA-binding site [nucleotide binding]; DNA binding site 768492004509 FCD domain; Region: FCD; pfam07729 768492004510 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 768492004511 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 768492004512 putative ligand binding site [chemical binding]; other site 768492004513 HEAT repeats; Region: HEAT_2; pfam13646 768492004514 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 768492004515 TM-ABC transporter signature motif; other site 768492004516 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 768492004517 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 768492004518 TM-ABC transporter signature motif; other site 768492004519 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 768492004520 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 768492004521 Walker A/P-loop; other site 768492004522 ATP binding site [chemical binding]; other site 768492004523 Q-loop/lid; other site 768492004524 ABC transporter signature motif; other site 768492004525 Walker B; other site 768492004526 D-loop; other site 768492004527 H-loop/switch region; other site 768492004528 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 768492004529 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 768492004530 Walker A/P-loop; other site 768492004531 ATP binding site [chemical binding]; other site 768492004532 Q-loop/lid; other site 768492004533 ABC transporter signature motif; other site 768492004534 Walker B; other site 768492004535 D-loop; other site 768492004536 H-loop/switch region; other site 768492004537 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 768492004538 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 768492004539 Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933 768492004540 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 768492004541 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 768492004542 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768492004543 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768492004544 hypothetical protein; Provisional; Region: PRK06185 768492004545 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 768492004546 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 768492004547 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492004548 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492004549 dimerization interface [polypeptide binding]; other site 768492004550 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 768492004551 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 768492004552 active site residue [active] 768492004553 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 768492004554 active site residue [active] 768492004555 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 768492004556 nudix motif; other site 768492004557 Uncharacterized conserved protein [Function unknown]; Region: COG1683 768492004558 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492004559 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 768492004560 NAD(P) binding site [chemical binding]; other site 768492004561 active site 768492004562 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 768492004563 Helix-turn-helix domain; Region: HTH_18; pfam12833 768492004564 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768492004565 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492004566 DNA-binding site [nucleotide binding]; DNA binding site 768492004567 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492004568 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492004569 homodimer interface [polypeptide binding]; other site 768492004570 catalytic residue [active] 768492004571 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 768492004572 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 768492004573 putative C-terminal domain interface [polypeptide binding]; other site 768492004574 putative GSH binding site (G-site) [chemical binding]; other site 768492004575 putative dimer interface [polypeptide binding]; other site 768492004576 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 768492004577 putative N-terminal domain interface [polypeptide binding]; other site 768492004578 putative dimer interface [polypeptide binding]; other site 768492004579 putative substrate binding pocket (H-site) [chemical binding]; other site 768492004580 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768492004581 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768492004582 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 768492004583 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 768492004584 Isochorismatase family; Region: Isochorismatase; pfam00857 768492004585 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 768492004586 catalytic triad [active] 768492004587 dimer interface [polypeptide binding]; other site 768492004588 conserved cis-peptide bond; other site 768492004589 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492004590 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492004591 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492004592 dimerization interface [polypeptide binding]; other site 768492004593 Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764 768492004594 Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509 768492004595 Fatty acid desaturase; Region: FA_desaturase; pfam00487 768492004596 putative di-iron ligands [ion binding]; other site 768492004597 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 768492004598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492004599 dimer interface [polypeptide binding]; other site 768492004600 conserved gate region; other site 768492004601 ABC-ATPase subunit interface; other site 768492004602 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 768492004603 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 768492004604 Walker A/P-loop; other site 768492004605 ATP binding site [chemical binding]; other site 768492004606 Q-loop/lid; other site 768492004607 ABC transporter signature motif; other site 768492004608 Walker B; other site 768492004609 D-loop; other site 768492004610 H-loop/switch region; other site 768492004611 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 768492004612 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492004613 putative PBP binding loops; other site 768492004614 dimer interface [polypeptide binding]; other site 768492004615 ABC-ATPase subunit interface; other site 768492004616 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 768492004617 short chain dehydrogenase; Provisional; Region: PRK07041 768492004618 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492004619 NAD(P) binding site [chemical binding]; other site 768492004620 active site 768492004621 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492004622 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492004623 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492004624 putative effector binding pocket; other site 768492004625 dimerization interface [polypeptide binding]; other site 768492004626 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 768492004627 EamA-like transporter family; Region: EamA; pfam00892 768492004628 EamA-like transporter family; Region: EamA; pfam00892 768492004629 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 768492004630 Predicted transcriptional regulator [Transcription]; Region: COG2345 768492004631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492004632 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768492004633 putative substrate translocation pore; other site 768492004634 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768492004635 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768492004636 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492004637 AzlC protein; Region: AzlC; cl00570 768492004638 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 768492004639 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492004640 non-specific DNA binding site [nucleotide binding]; other site 768492004641 salt bridge; other site 768492004642 sequence-specific DNA binding site [nucleotide binding]; other site 768492004643 putative acetyltransferase; Provisional; Region: PRK03624 768492004644 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492004645 Coenzyme A binding pocket [chemical binding]; other site 768492004646 Predicted secreted acid phosphatase [General function prediction only]; Region: COG2503 768492004647 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492004648 Coenzyme A binding pocket [chemical binding]; other site 768492004649 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 768492004650 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 768492004651 trimer interface [polypeptide binding]; other site 768492004652 eyelet of channel; other site 768492004653 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 768492004654 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 768492004655 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 768492004656 DEAD_2; Region: DEAD_2; pfam06733 768492004657 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 768492004658 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768492004659 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768492004660 putative DNA binding site [nucleotide binding]; other site 768492004661 putative Zn2+ binding site [ion binding]; other site 768492004662 AsnC family; Region: AsnC_trans_reg; pfam01037 768492004663 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768492004664 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 768492004665 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492004666 putative substrate translocation pore; other site 768492004667 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492004668 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492004669 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 768492004670 putative effector binding pocket; other site 768492004671 putative dimerization interface [polypeptide binding]; other site 768492004672 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 768492004673 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492004674 salt bridge; other site 768492004675 non-specific DNA binding site [nucleotide binding]; other site 768492004676 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768492004677 sequence-specific DNA binding site [nucleotide binding]; other site 768492004678 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 768492004679 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 768492004680 glycosyl transferase family protein; Provisional; Region: PRK08136 768492004681 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 768492004682 Peptidase M3-like family, a zincin metallopeptidase, includes M3 and M32 families; Region: M3_like; cd06258 768492004683 active site 768492004684 Zn binding site [ion binding]; other site 768492004685 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 768492004686 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 768492004687 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 768492004688 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492004689 S-adenosylmethionine binding site [chemical binding]; other site 768492004690 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 768492004691 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 768492004692 Walker A/P-loop; other site 768492004693 ATP binding site [chemical binding]; other site 768492004694 Q-loop/lid; other site 768492004695 ABC transporter signature motif; other site 768492004696 Walker B; other site 768492004697 D-loop; other site 768492004698 H-loop/switch region; other site 768492004699 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768492004700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492004701 dimer interface [polypeptide binding]; other site 768492004702 conserved gate region; other site 768492004703 putative PBP binding loops; other site 768492004704 ABC-ATPase subunit interface; other site 768492004705 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 768492004706 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492004707 substrate binding pocket [chemical binding]; other site 768492004708 membrane-bound complex binding site; other site 768492004709 hinge residues; other site 768492004710 hypothetical protein; Provisional; Region: PRK11019 768492004711 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 768492004712 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 768492004713 dimerization interface [polypeptide binding]; other site 768492004714 DPS ferroxidase diiron center [ion binding]; other site 768492004715 ion pore; other site 768492004716 AAA domain; Region: AAA_17; pfam13207 768492004717 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 768492004718 threonine and homoserine efflux system; Provisional; Region: PRK10532 768492004719 EamA-like transporter family; Region: EamA; pfam00892 768492004720 outer membrane protein X; Provisional; Region: ompX; PRK09408 768492004721 Predicted amidohydrolase [General function prediction only]; Region: COG0388 768492004722 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_7; cd07585 768492004723 putative active site [active] 768492004724 catalytic triad [active] 768492004725 putative dimer interface [polypeptide binding]; other site 768492004726 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492004727 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492004728 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 768492004729 dimerization interface [polypeptide binding]; other site 768492004730 substrate binding pocket [chemical binding]; other site 768492004731 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768492004732 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768492004733 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 768492004734 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 768492004735 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 768492004736 Moco binding site; other site 768492004737 metal coordination site [ion binding]; other site 768492004738 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 768492004739 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768492004740 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768492004741 dimerization interface [polypeptide binding]; other site 768492004742 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492004743 dimer interface [polypeptide binding]; other site 768492004744 phosphorylation site [posttranslational modification] 768492004745 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492004746 ATP binding site [chemical binding]; other site 768492004747 Mg2+ binding site [ion binding]; other site 768492004748 G-X-G motif; other site 768492004749 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768492004750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492004751 active site 768492004752 phosphorylation site [posttranslational modification] 768492004753 intermolecular recognition site; other site 768492004754 dimerization interface [polypeptide binding]; other site 768492004755 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768492004756 DNA binding site [nucleotide binding] 768492004757 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 768492004758 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 768492004759 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 768492004760 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 768492004761 Moco binding site; other site 768492004762 metal coordination site [ion binding]; other site 768492004763 choline transport protein BetT; Provisional; Region: PRK09928 768492004764 transcriptional regulator BetI; Validated; Region: PRK00767 768492004765 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768492004766 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 768492004767 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 768492004768 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 768492004769 tetrameric interface [polypeptide binding]; other site 768492004770 NAD binding site [chemical binding]; other site 768492004771 catalytic residues [active] 768492004772 choline dehydrogenase; Validated; Region: PRK02106 768492004773 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 768492004774 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 768492004775 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 768492004776 active site 768492004777 FMN binding site [chemical binding]; other site 768492004778 substrate binding site [chemical binding]; other site 768492004779 3Fe-4S cluster binding site [ion binding]; other site 768492004780 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 768492004781 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 768492004782 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768492004783 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 768492004784 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 768492004785 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 768492004786 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 768492004787 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 768492004788 PapC N-terminal domain; Region: PapC_N; pfam13954 768492004789 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 768492004790 PapC C-terminal domain; Region: PapC_C; pfam13953 768492004791 putative major fimbrial protein SthE; Provisional; Region: PRK15292 768492004792 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 768492004793 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 768492004794 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492004795 malate:quinone oxidoreductase; Validated; Region: PRK05257 768492004796 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 768492004797 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492004798 NADH(P)-binding; Region: NAD_binding_10; pfam13460 768492004799 NAD(P) binding site [chemical binding]; other site 768492004800 active site 768492004801 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492004802 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768492004803 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768492004804 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768492004805 alkaline phosphatase; Provisional; Region: PRK10518 768492004806 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 768492004807 dimer interface [polypeptide binding]; other site 768492004808 active site 768492004809 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 768492004810 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 768492004811 C-terminal domain interface [polypeptide binding]; other site 768492004812 GSH binding site (G-site) [chemical binding]; other site 768492004813 dimer interface [polypeptide binding]; other site 768492004814 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 768492004815 dimer interface [polypeptide binding]; other site 768492004816 N-terminal domain interface [polypeptide binding]; other site 768492004817 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768492004818 dimerization interface [polypeptide binding]; other site 768492004819 putative DNA binding site [nucleotide binding]; other site 768492004820 putative Zn2+ binding site [ion binding]; other site 768492004821 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 768492004822 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 768492004823 Isochorismatase family; Region: Isochorismatase; pfam00857 768492004824 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 768492004825 catalytic triad [active] 768492004826 conserved cis-peptide bond; other site 768492004827 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492004828 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492004829 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492004830 putative effector binding pocket; other site 768492004831 dimerization interface [polypeptide binding]; other site 768492004832 AAA domain; Region: AAA_33; pfam13671 768492004833 AAA domain; Region: AAA_17; pfam13207 768492004834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492004835 metabolite-proton symporter; Region: 2A0106; TIGR00883 768492004836 putative substrate translocation pore; other site 768492004837 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492004838 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492004839 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492004840 putative effector binding pocket; other site 768492004841 dimerization interface [polypeptide binding]; other site 768492004842 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 768492004843 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768492004844 Walker A/P-loop; other site 768492004845 ATP binding site [chemical binding]; other site 768492004846 Q-loop/lid; other site 768492004847 ABC transporter signature motif; other site 768492004848 Walker B; other site 768492004849 D-loop; other site 768492004850 H-loop/switch region; other site 768492004851 ABC transporter; Region: ABC_tran_2; pfam12848 768492004852 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768492004853 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 768492004854 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 768492004855 ATP binding site [chemical binding]; other site 768492004856 substrate interface [chemical binding]; other site 768492004857 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 768492004858 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 768492004859 dimer interface [polypeptide binding]; other site 768492004860 putative functional site; other site 768492004861 putative MPT binding site; other site 768492004862 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 768492004863 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 768492004864 catalytic nucleophile [active] 768492004865 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 768492004866 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768492004867 Walker A/P-loop; other site 768492004868 ATP binding site [chemical binding]; other site 768492004869 Q-loop/lid; other site 768492004870 ABC transporter signature motif; other site 768492004871 Walker B; other site 768492004872 D-loop; other site 768492004873 H-loop/switch region; other site 768492004874 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768492004875 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768492004876 Walker A/P-loop; other site 768492004877 ATP binding site [chemical binding]; other site 768492004878 Q-loop/lid; other site 768492004879 ABC transporter signature motif; other site 768492004880 Walker B; other site 768492004881 D-loop; other site 768492004882 H-loop/switch region; other site 768492004883 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768492004884 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 768492004885 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 768492004886 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 768492004887 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492004888 dimer interface [polypeptide binding]; other site 768492004889 conserved gate region; other site 768492004890 putative PBP binding loops; other site 768492004891 ABC-ATPase subunit interface; other site 768492004892 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 768492004893 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492004894 dimer interface [polypeptide binding]; other site 768492004895 conserved gate region; other site 768492004896 putative PBP binding loops; other site 768492004897 ABC-ATPase subunit interface; other site 768492004898 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 768492004899 CcdB protein; Region: CcdB; pfam01845 768492004900 S-formylglutathione hydrolase; Region: PLN02442 768492004901 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 768492004902 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 768492004903 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 768492004904 substrate binding site [chemical binding]; other site 768492004905 catalytic Zn binding site [ion binding]; other site 768492004906 NAD binding site [chemical binding]; other site 768492004907 structural Zn binding site [ion binding]; other site 768492004908 dimer interface [polypeptide binding]; other site 768492004909 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492004910 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492004911 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 768492004912 putative dimerization interface [polypeptide binding]; other site 768492004913 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492004914 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768492004915 putative substrate translocation pore; other site 768492004916 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 768492004917 active site 768492004918 Predicted membrane protein [Function unknown]; Region: COG2311 768492004919 hypothetical protein; Provisional; Region: PRK10835 768492004920 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 768492004921 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492004922 DNA binding site [nucleotide binding] 768492004923 domain linker motif; other site 768492004924 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 768492004925 dimerization interface (closed form) [polypeptide binding]; other site 768492004926 ligand binding site [chemical binding]; other site 768492004927 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 768492004928 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 768492004929 ligand binding site [chemical binding]; other site 768492004930 calcium binding site [ion binding]; other site 768492004931 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768492004932 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 768492004933 Walker A/P-loop; other site 768492004934 ATP binding site [chemical binding]; other site 768492004935 Q-loop/lid; other site 768492004936 ABC transporter signature motif; other site 768492004937 Walker B; other site 768492004938 D-loop; other site 768492004939 H-loop/switch region; other site 768492004940 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768492004941 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768492004942 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768492004943 TM-ABC transporter signature motif; other site 768492004944 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 768492004945 putative active site [active] 768492004946 malate dehydrogenase; Provisional; Region: PRK13529 768492004947 Malic enzyme, N-terminal domain; Region: malic; pfam00390 768492004948 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 768492004949 NAD(P) binding site [chemical binding]; other site 768492004950 cytidine deaminase; Provisional; Region: PRK09027 768492004951 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 768492004952 active site 768492004953 catalytic motif [active] 768492004954 Zn binding site [ion binding]; other site 768492004955 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 768492004956 active site 768492004957 catalytic motif [active] 768492004958 Zn binding site [ion binding]; other site 768492004959 hypothetical protein; Provisional; Region: PRK10711 768492004960 hypothetical protein; Provisional; Region: PRK01821 768492004961 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768492004962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492004963 putative substrate translocation pore; other site 768492004964 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 768492004965 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 768492004966 putative ligand binding site [chemical binding]; other site 768492004967 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 768492004968 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 768492004969 active site 768492004970 HIGH motif; other site 768492004971 KMSKS motif; other site 768492004972 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 768492004973 tRNA binding surface [nucleotide binding]; other site 768492004974 anticodon binding site; other site 768492004975 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 768492004976 dimer interface [polypeptide binding]; other site 768492004977 putative tRNA-binding site [nucleotide binding]; other site 768492004978 antiporter inner membrane protein; Provisional; Region: PRK11670 768492004979 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 768492004980 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 768492004981 active site 768492004982 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 768492004983 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 768492004984 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 768492004985 ATP-binding site [chemical binding]; other site 768492004986 Sugar specificity; other site 768492004987 Pyrimidine base specificity; other site 768492004988 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 768492004989 trimer interface [polypeptide binding]; other site 768492004990 active site 768492004991 putative assembly protein; Provisional; Region: PRK10833 768492004992 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 768492004993 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 768492004994 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 768492004995 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 768492004996 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 768492004997 FOG: CBS domain [General function prediction only]; Region: COG0517 768492004998 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 768492004999 Transporter associated domain; Region: CorC_HlyC; smart01091 768492005000 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 768492005001 active site 768492005002 tetramer interface; other site 768492005003 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 768492005004 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 768492005005 active site 768492005006 tetramer interface; other site 768492005007 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 768492005008 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 768492005009 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 768492005010 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768492005011 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 768492005012 polysaccharide export protein Wza; Provisional; Region: PRK15078 768492005013 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 768492005014 SLBB domain; Region: SLBB; pfam10531 768492005015 SLBB domain; Region: SLBB; pfam10531 768492005016 Low molecular weight phosphatase family; Region: LMWPc; cd00115 768492005017 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 768492005018 active site 768492005019 tyrosine kinase; Provisional; Region: PRK11519 768492005020 Chain length determinant protein; Region: Wzz; pfam02706 768492005021 Chain length determinant protein; Region: Wzz; cl15801 768492005022 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 768492005023 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 768492005024 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 768492005025 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 768492005026 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768492005027 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 768492005028 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768492005029 putative ADP-binding pocket [chemical binding]; other site 768492005030 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 768492005031 Bacterial sugar transferase; Region: Bac_transf; pfam02397 768492005032 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 768492005033 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 768492005034 Walker A/P-loop; other site 768492005035 ATP binding site [chemical binding]; other site 768492005036 Q-loop/lid; other site 768492005037 ABC transporter signature motif; other site 768492005038 Walker B; other site 768492005039 D-loop; other site 768492005040 H-loop/switch region; other site 768492005041 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 768492005042 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768492005043 HlyD family secretion protein; Region: HlyD_3; pfam13437 768492005044 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 768492005045 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 768492005046 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 768492005047 Substrate binding site; other site 768492005048 Cupin domain; Region: Cupin_2; cl17218 768492005049 phosphomannomutase CpsG; Provisional; Region: PRK15414 768492005050 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 768492005051 active site 768492005052 substrate binding site [chemical binding]; other site 768492005053 metal binding site [ion binding]; metal-binding site 768492005054 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 768492005055 UDP-glucose 4-epimerase; Region: PLN02240 768492005056 NAD binding site [chemical binding]; other site 768492005057 homodimer interface [polypeptide binding]; other site 768492005058 active site 768492005059 substrate binding site [chemical binding]; other site 768492005060 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 768492005061 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 768492005062 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 768492005063 NADP binding site [chemical binding]; other site 768492005064 active site 768492005065 putative substrate binding site [chemical binding]; other site 768492005066 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 768492005067 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 768492005068 active site 768492005069 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 768492005070 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 768492005071 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 768492005072 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 768492005073 Walker A/P-loop; other site 768492005074 ATP binding site [chemical binding]; other site 768492005075 Q-loop/lid; other site 768492005076 ABC transporter signature motif; other site 768492005077 Walker B; other site 768492005078 D-loop; other site 768492005079 H-loop/switch region; other site 768492005080 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 768492005081 putative carbohydrate binding site [chemical binding]; other site 768492005082 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 768492005083 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 768492005084 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 768492005085 active site 768492005086 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768492005087 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 768492005088 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 768492005089 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 768492005090 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 768492005091 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 768492005092 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 768492005093 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 768492005094 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 768492005095 metal binding site [ion binding]; metal-binding site 768492005096 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 768492005097 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 768492005098 substrate binding site [chemical binding]; other site 768492005099 glutamase interaction surface [polypeptide binding]; other site 768492005100 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 768492005101 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 768492005102 catalytic residues [active] 768492005103 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 768492005104 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 768492005105 putative active site [active] 768492005106 oxyanion strand; other site 768492005107 catalytic triad [active] 768492005108 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 768492005109 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492005110 active site 768492005111 motif I; other site 768492005112 motif II; other site 768492005113 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 768492005114 putative active site pocket [active] 768492005115 4-fold oligomerization interface [polypeptide binding]; other site 768492005116 metal binding residues [ion binding]; metal-binding site 768492005117 3-fold/trimer interface [polypeptide binding]; other site 768492005118 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 768492005119 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492005120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492005121 homodimer interface [polypeptide binding]; other site 768492005122 catalytic residue [active] 768492005123 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 768492005124 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 768492005125 NAD binding site [chemical binding]; other site 768492005126 dimerization interface [polypeptide binding]; other site 768492005127 product binding site; other site 768492005128 substrate binding site [chemical binding]; other site 768492005129 zinc binding site [ion binding]; other site 768492005130 catalytic residues [active] 768492005131 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 768492005132 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 768492005133 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 768492005134 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768492005135 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 768492005136 putative NAD(P) binding site [chemical binding]; other site 768492005137 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492005138 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492005139 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768492005140 dimerization interface [polypeptide binding]; other site 768492005141 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 768492005142 agmatinase; Region: agmatinase; TIGR01230 768492005143 oligomer interface [polypeptide binding]; other site 768492005144 putative active site [active] 768492005145 Mn binding site [ion binding]; other site 768492005146 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 768492005147 Na binding site [ion binding]; other site 768492005148 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 768492005149 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 768492005150 oligomer interface [polypeptide binding]; other site 768492005151 metal binding site [ion binding]; metal-binding site 768492005152 metal binding site [ion binding]; metal-binding site 768492005153 putative Cl binding site [ion binding]; other site 768492005154 basic sphincter; other site 768492005155 hydrophobic gate; other site 768492005156 periplasmic entrance; other site 768492005157 putative acetyltransferase; Provisional; Region: PRK03624 768492005158 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492005159 Coenzyme A binding pocket [chemical binding]; other site 768492005160 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 768492005161 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 768492005162 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 768492005163 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 768492005164 putative C-terminal domain interface [polypeptide binding]; other site 768492005165 putative GSH binding site (G-site) [chemical binding]; other site 768492005166 putative dimer interface [polypeptide binding]; other site 768492005167 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 768492005168 putative N-terminal domain interface [polypeptide binding]; other site 768492005169 putative dimer interface [polypeptide binding]; other site 768492005170 putative substrate binding pocket (H-site) [chemical binding]; other site 768492005171 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 768492005172 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 768492005173 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 768492005174 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 768492005175 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 768492005176 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 768492005177 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 768492005178 homodimer interface [polypeptide binding]; other site 768492005179 substrate-cofactor binding pocket; other site 768492005180 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492005181 catalytic residue [active] 768492005182 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 768492005183 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 768492005184 dimer interface [polypeptide binding]; other site 768492005185 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492005186 catalytic residue [active] 768492005187 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 768492005188 FOG: CBS domain [General function prediction only]; Region: COG0517 768492005189 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 768492005190 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 768492005191 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 768492005192 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 768492005193 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 768492005194 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 768492005195 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 768492005196 serine transporter; Region: stp; TIGR00814 768492005197 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 768492005198 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 768492005199 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 768492005200 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 768492005201 intersubunit interface [polypeptide binding]; other site 768492005202 active site 768492005203 catalytic residue [active] 768492005204 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 768492005205 active site 768492005206 catalytic residues [active] 768492005207 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 768492005208 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 768492005209 active site 768492005210 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 768492005211 active site 768492005212 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 768492005213 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 768492005214 secondary substrate binding site; other site 768492005215 primary substrate binding site; other site 768492005216 inhibition loop; other site 768492005217 dimerization interface [polypeptide binding]; other site 768492005218 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 768492005219 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 768492005220 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492005221 catalytic residue [active] 768492005222 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 768492005223 Predicted transcriptional regulator [Transcription]; Region: COG3655 768492005224 sequence-specific DNA binding site [nucleotide binding]; other site 768492005225 salt bridge; other site 768492005226 Fucose-binding lectin II (PA-IIL); Region: PA-IIL; pfam07472 768492005227 putative transporter; Provisional; Region: PRK04972 768492005228 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 768492005229 TrkA-C domain; Region: TrkA_C; pfam02080 768492005230 TrkA-C domain; Region: TrkA_C; pfam02080 768492005231 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 768492005232 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 768492005233 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 768492005234 GSH binding site [chemical binding]; other site 768492005235 catalytic residues [active] 768492005236 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 768492005237 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 768492005238 RimK-like ATP-grasp domain; Region: RimK; pfam08443 768492005239 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 768492005240 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 768492005241 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 768492005242 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 768492005243 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 768492005244 Walker A/P-loop; other site 768492005245 ATP binding site [chemical binding]; other site 768492005246 Q-loop/lid; other site 768492005247 ABC transporter signature motif; other site 768492005248 Walker B; other site 768492005249 D-loop; other site 768492005250 H-loop/switch region; other site 768492005251 TOBE domain; Region: TOBE_2; pfam08402 768492005252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492005253 dimer interface [polypeptide binding]; other site 768492005254 conserved gate region; other site 768492005255 putative PBP binding loops; other site 768492005256 ABC-ATPase subunit interface; other site 768492005257 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 768492005258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492005259 dimer interface [polypeptide binding]; other site 768492005260 conserved gate region; other site 768492005261 putative PBP binding loops; other site 768492005262 ABC-ATPase subunit interface; other site 768492005263 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 768492005264 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 768492005265 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492005266 S-adenosylmethionine binding site [chemical binding]; other site 768492005267 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 768492005268 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492005269 substrate binding pocket [chemical binding]; other site 768492005270 membrane-bound complex binding site; other site 768492005271 hinge residues; other site 768492005272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492005273 dimer interface [polypeptide binding]; other site 768492005274 conserved gate region; other site 768492005275 putative PBP binding loops; other site 768492005276 ABC-ATPase subunit interface; other site 768492005277 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768492005278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492005279 dimer interface [polypeptide binding]; other site 768492005280 conserved gate region; other site 768492005281 putative PBP binding loops; other site 768492005282 ABC-ATPase subunit interface; other site 768492005283 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 768492005284 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492005285 substrate binding pocket [chemical binding]; other site 768492005286 membrane-bound complex binding site; other site 768492005287 hinge residues; other site 768492005288 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 768492005289 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768492005290 Walker A/P-loop; other site 768492005291 ATP binding site [chemical binding]; other site 768492005292 Q-loop/lid; other site 768492005293 ABC transporter signature motif; other site 768492005294 Walker B; other site 768492005295 D-loop; other site 768492005296 H-loop/switch region; other site 768492005297 putative lipoprotein; Provisional; Region: PRK10533 768492005298 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768492005299 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768492005300 dimerization interface [polypeptide binding]; other site 768492005301 putative DNA binding site [nucleotide binding]; other site 768492005302 putative Zn2+ binding site [ion binding]; other site 768492005303 AsnC family; Region: AsnC_trans_reg; pfam01037 768492005304 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 768492005305 hypothetical protein; Provisional; Region: PRK02877 768492005306 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 768492005307 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 768492005308 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 768492005309 amidase catalytic site [active] 768492005310 Zn binding residues [ion binding]; other site 768492005311 substrate binding site [chemical binding]; other site 768492005312 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768492005313 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492005314 NAD(P) binding site [chemical binding]; other site 768492005315 active site 768492005316 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 768492005317 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 768492005318 putative NAD(P) binding site [chemical binding]; other site 768492005319 putative active site [active] 768492005320 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 768492005321 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 768492005322 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 768492005323 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 768492005324 tetramer interface [polypeptide binding]; other site 768492005325 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492005326 catalytic residue [active] 768492005327 pyruvate dehydrogenase; Provisional; Region: PRK09124 768492005328 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 768492005329 PYR/PP interface [polypeptide binding]; other site 768492005330 dimer interface [polypeptide binding]; other site 768492005331 tetramer interface [polypeptide binding]; other site 768492005332 TPP binding site [chemical binding]; other site 768492005333 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768492005334 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 768492005335 TPP-binding site [chemical binding]; other site 768492005336 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 768492005337 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 768492005338 FAD binding pocket [chemical binding]; other site 768492005339 FAD binding motif [chemical binding]; other site 768492005340 phosphate binding motif [ion binding]; other site 768492005341 beta-alpha-beta structure motif; other site 768492005342 NAD binding pocket [chemical binding]; other site 768492005343 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768492005344 catalytic loop [active] 768492005345 iron binding site [ion binding]; other site 768492005346 hybrid cluster protein; Provisional; Region: PRK05290 768492005347 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768492005348 ACS interaction site; other site 768492005349 CODH interaction site; other site 768492005350 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768492005351 ACS interaction site; other site 768492005352 CODH interaction site; other site 768492005353 metal cluster binding site [ion binding]; other site 768492005354 Predicted membrane protein [Function unknown]; Region: COG2431 768492005355 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 768492005356 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 768492005357 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 768492005358 putative active site [active] 768492005359 putative metal-binding site [ion binding]; other site 768492005360 Protein of unknown function (DUF535); Region: DUF535; pfam04393 768492005361 macrolide transporter subunit MacA; Provisional; Region: PRK11578 768492005362 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768492005363 HlyD family secretion protein; Region: HlyD_3; pfam13437 768492005364 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 768492005365 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768492005366 Walker A/P-loop; other site 768492005367 ATP binding site [chemical binding]; other site 768492005368 Q-loop/lid; other site 768492005369 ABC transporter signature motif; other site 768492005370 Walker B; other site 768492005371 D-loop; other site 768492005372 H-loop/switch region; other site 768492005373 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768492005374 FtsX-like permease family; Region: FtsX; pfam02687 768492005375 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768492005376 DNA-binding site [nucleotide binding]; DNA binding site 768492005377 RNA-binding motif; other site 768492005378 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 768492005379 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 768492005380 Clp amino terminal domain; Region: Clp_N; pfam02861 768492005381 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492005382 Walker A motif; other site 768492005383 ATP binding site [chemical binding]; other site 768492005384 Walker B motif; other site 768492005385 arginine finger; other site 768492005386 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492005387 Walker A motif; other site 768492005388 ATP binding site [chemical binding]; other site 768492005389 Walker B motif; other site 768492005390 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 768492005391 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 768492005392 rRNA binding site [nucleotide binding]; other site 768492005393 predicted 30S ribosome binding site; other site 768492005394 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 768492005395 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 768492005396 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768492005397 Walker A/P-loop; other site 768492005398 ATP binding site [chemical binding]; other site 768492005399 Q-loop/lid; other site 768492005400 ABC transporter signature motif; other site 768492005401 Walker B; other site 768492005402 D-loop; other site 768492005403 H-loop/switch region; other site 768492005404 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 768492005405 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768492005406 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768492005407 Walker A/P-loop; other site 768492005408 ATP binding site [chemical binding]; other site 768492005409 Q-loop/lid; other site 768492005410 ABC transporter signature motif; other site 768492005411 Walker B; other site 768492005412 D-loop; other site 768492005413 H-loop/switch region; other site 768492005414 glutathionine S-transferase; Provisional; Region: PRK10542 768492005415 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 768492005416 C-terminal domain interface [polypeptide binding]; other site 768492005417 GSH binding site (G-site) [chemical binding]; other site 768492005418 dimer interface [polypeptide binding]; other site 768492005419 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 768492005420 dimer interface [polypeptide binding]; other site 768492005421 N-terminal domain interface [polypeptide binding]; other site 768492005422 substrate binding pocket (H-site) [chemical binding]; other site 768492005423 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492005424 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492005425 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768492005426 dimerization interface [polypeptide binding]; other site 768492005427 thioredoxin reductase; Provisional; Region: PRK10262 768492005428 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768492005429 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768492005430 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 768492005431 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768492005432 putative DNA binding site [nucleotide binding]; other site 768492005433 putative Zn2+ binding site [ion binding]; other site 768492005434 AsnC family; Region: AsnC_trans_reg; pfam01037 768492005435 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 768492005436 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 768492005437 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 768492005438 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 768492005439 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 768492005440 recombination factor protein RarA; Reviewed; Region: PRK13342 768492005441 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492005442 Walker A motif; other site 768492005443 ATP binding site [chemical binding]; other site 768492005444 Walker B motif; other site 768492005445 arginine finger; other site 768492005446 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 768492005447 seryl-tRNA synthetase; Provisional; Region: PRK05431 768492005448 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 768492005449 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 768492005450 dimer interface [polypeptide binding]; other site 768492005451 active site 768492005452 motif 1; other site 768492005453 motif 2; other site 768492005454 motif 3; other site 768492005455 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 768492005456 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768492005457 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768492005458 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492005459 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 768492005460 putative MFS family transporter protein; Provisional; Region: PRK03633 768492005461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492005462 putative substrate translocation pore; other site 768492005463 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 768492005464 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768492005465 FeS/SAM binding site; other site 768492005466 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 768492005467 Pyruvate formate lyase 1; Region: PFL1; cd01678 768492005468 coenzyme A binding site [chemical binding]; other site 768492005469 active site 768492005470 catalytic residues [active] 768492005471 glycine loop; other site 768492005472 formate transporter; Provisional; Region: PRK10805 768492005473 uncharacterized domain; Region: TIGR00702 768492005474 YcaO-like family; Region: YcaO; pfam02624 768492005475 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 768492005476 homodimer interface [polypeptide binding]; other site 768492005477 active site 768492005478 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 768492005479 homodimer interface [polypeptide binding]; other site 768492005480 substrate-cofactor binding pocket; other site 768492005481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492005482 catalytic residue [active] 768492005483 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 768492005484 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 768492005485 hinge; other site 768492005486 active site 768492005487 cytidylate kinase; Provisional; Region: cmk; PRK00023 768492005488 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 768492005489 CMP-binding site; other site 768492005490 The sites determining sugar specificity; other site 768492005491 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 768492005492 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 768492005493 RNA binding site [nucleotide binding]; other site 768492005494 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 768492005495 RNA binding site [nucleotide binding]; other site 768492005496 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 768492005497 RNA binding site [nucleotide binding]; other site 768492005498 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 768492005499 RNA binding site [nucleotide binding]; other site 768492005500 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 768492005501 RNA binding site [nucleotide binding]; other site 768492005502 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 768492005503 IHF dimer interface [polypeptide binding]; other site 768492005504 IHF - DNA interface [nucleotide binding]; other site 768492005505 ComEC family competence protein; Provisional; Region: PRK11539 768492005506 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 768492005507 Competence protein; Region: Competence; pfam03772 768492005508 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 768492005509 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 768492005510 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768492005511 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 768492005512 Walker A/P-loop; other site 768492005513 ATP binding site [chemical binding]; other site 768492005514 Q-loop/lid; other site 768492005515 ABC transporter signature motif; other site 768492005516 Walker B; other site 768492005517 D-loop; other site 768492005518 H-loop/switch region; other site 768492005519 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 768492005520 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 768492005521 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 768492005522 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 768492005523 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768492005524 DNA-binding site [nucleotide binding]; DNA binding site 768492005525 RNA-binding motif; other site 768492005526 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768492005527 DNA-binding site [nucleotide binding]; DNA binding site 768492005528 RNA-binding motif; other site 768492005529 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 768492005530 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 768492005531 Trm112p-like protein; Region: Trm112p; cl01066 768492005532 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 768492005533 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 768492005534 Ligand binding site; other site 768492005535 oligomer interface; other site 768492005536 hypothetical protein; Provisional; Region: PRK10593 768492005537 Uncharacterized conserved protein [Function unknown]; Region: COG1434 768492005538 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 768492005539 putative active site [active] 768492005540 Methyltransferase domain; Region: Methyltransf_31; pfam13847 768492005541 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492005542 S-adenosylmethionine binding site [chemical binding]; other site 768492005543 condesin subunit F; Provisional; Region: PRK05260 768492005544 condesin subunit E; Provisional; Region: PRK05256 768492005545 cell division protein MukB; Provisional; Region: mukB; PRK04863 768492005546 P-loop containing region of AAA domain; Region: AAA_29; cl17516 768492005547 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 768492005548 murein L,D-transpeptidase; Provisional; Region: PRK10594 768492005549 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 768492005550 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 768492005551 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 768492005552 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 768492005553 Peptidase M15; Region: Peptidase_M15_3; cl01194 768492005554 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 768492005555 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 768492005556 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492005557 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492005558 homodimer interface [polypeptide binding]; other site 768492005559 catalytic residue [active] 768492005560 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 768492005561 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 768492005562 trimer interface [polypeptide binding]; other site 768492005563 eyelet of channel; other site 768492005564 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 768492005565 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 768492005566 putative dimer interface [polypeptide binding]; other site 768492005567 putative anticodon binding site; other site 768492005568 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 768492005569 homodimer interface [polypeptide binding]; other site 768492005570 motif 1; other site 768492005571 motif 2; other site 768492005572 active site 768492005573 motif 3; other site 768492005574 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 768492005575 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 768492005576 active site 768492005577 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768492005578 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768492005579 metal binding site [ion binding]; metal-binding site 768492005580 active site 768492005581 I-site; other site 768492005582 aminopeptidase N; Provisional; Region: pepN; PRK14015 768492005583 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 768492005584 active site 768492005585 Zn binding site [ion binding]; other site 768492005586 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 768492005587 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 768492005588 Walker A/P-loop; other site 768492005589 ATP binding site [chemical binding]; other site 768492005590 Q-loop/lid; other site 768492005591 ABC transporter signature motif; other site 768492005592 Walker B; other site 768492005593 D-loop; other site 768492005594 H-loop/switch region; other site 768492005595 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 768492005596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492005597 dimer interface [polypeptide binding]; other site 768492005598 conserved gate region; other site 768492005599 putative PBP binding loops; other site 768492005600 ABC-ATPase subunit interface; other site 768492005601 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 768492005602 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 768492005603 active site 768492005604 dimer interface [polypeptide binding]; other site 768492005605 non-prolyl cis peptide bond; other site 768492005606 insertion regions; other site 768492005607 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 768492005608 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492005609 substrate binding pocket [chemical binding]; other site 768492005610 membrane-bound complex binding site; other site 768492005611 hinge residues; other site 768492005612 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 768492005613 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768492005614 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 768492005615 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 768492005616 quinone interaction residues [chemical binding]; other site 768492005617 active site 768492005618 catalytic residues [active] 768492005619 FMN binding site [chemical binding]; other site 768492005620 substrate binding site [chemical binding]; other site 768492005621 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 768492005622 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 768492005623 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 768492005624 MOSC domain; Region: MOSC; pfam03473 768492005625 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768492005626 catalytic loop [active] 768492005627 iron binding site [ion binding]; other site 768492005628 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 768492005629 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 768492005630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492005631 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492005632 S-adenosylmethionine binding site [chemical binding]; other site 768492005633 ABC transporter ATPase component; Reviewed; Region: PRK11147 768492005634 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768492005635 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768492005636 Walker A/P-loop; other site 768492005637 Walker A/P-loop; other site 768492005638 ATP binding site [chemical binding]; other site 768492005639 ATP binding site [chemical binding]; other site 768492005640 Q-loop/lid; other site 768492005641 Q-loop/lid; other site 768492005642 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768492005643 ABC transporter signature motif; other site 768492005644 Walker B; other site 768492005645 D-loop; other site 768492005646 ABC transporter; Region: ABC_tran_2; pfam12848 768492005647 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768492005648 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 768492005649 Paraquat-inducible protein A; Region: PqiA; pfam04403 768492005650 Paraquat-inducible protein A; Region: PqiA; pfam04403 768492005651 paraquat-inducible protein B; Provisional; Region: PRK10807 768492005652 mce related protein; Region: MCE; pfam02470 768492005653 mce related protein; Region: MCE; pfam02470 768492005654 mce related protein; Region: MCE; pfam02470 768492005655 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 768492005656 Protein of unknown function (DUF330); Region: DUF330; pfam03886 768492005657 Ribosome modulation factor; Region: RMF; pfam04957 768492005658 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 768492005659 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 768492005660 dimer interface [polypeptide binding]; other site 768492005661 active site 768492005662 Predicted transcriptional regulators [Transcription]; Region: COG1733 768492005663 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 768492005664 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 768492005665 active site 2 [active] 768492005666 dimer interface [polypeptide binding]; other site 768492005667 active site 1 [active] 768492005668 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 768492005669 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 768492005670 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 768492005671 outer membrane protein A; Reviewed; Region: PRK10808 768492005672 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 768492005673 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 768492005674 ligand binding site [chemical binding]; other site 768492005675 SOS cell division inhibitor; Provisional; Region: PRK10595 768492005676 TfoX N-terminal domain; Region: TfoX_N; pfam04993 768492005677 TfoX C-terminal domain; Region: TfoX_C; pfam04994 768492005678 TIGR01666 family membrane protein; Region: YCCS 768492005679 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 768492005680 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 768492005681 Predicted membrane protein [Function unknown]; Region: COG3304 768492005682 Domain of unknown function (DUF307); Region: DUF307; pfam03733 768492005683 Domain of unknown function (DUF307); Region: DUF307; pfam03733 768492005684 DNA helicase IV; Provisional; Region: helD; PRK11054 768492005685 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 768492005686 Part of AAA domain; Region: AAA_19; pfam13245 768492005687 Family description; Region: UvrD_C_2; pfam13538 768492005688 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 768492005689 active site 768492005690 dimer interfaces [polypeptide binding]; other site 768492005691 catalytic residues [active] 768492005692 hypothetical protein; Provisional; Region: PRK03641 768492005693 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 768492005694 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 768492005695 heat shock protein HspQ; Provisional; Region: PRK14129 768492005696 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 768492005697 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 768492005698 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 768492005699 putative RNA binding site [nucleotide binding]; other site 768492005700 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492005701 S-adenosylmethionine binding site [chemical binding]; other site 768492005702 acylphosphatase; Provisional; Region: PRK14426 768492005703 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 768492005704 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 768492005705 YccA-like proteins; Region: YccA_like; cd10433 768492005706 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 768492005707 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 768492005708 hypothetical protein; Provisional; Region: PRK14851 768492005709 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 768492005710 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 768492005711 REDY-like protein HapK; Region: HapK; pfam11639 768492005712 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 768492005713 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 768492005714 active site 768492005715 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 768492005716 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 768492005717 acyl-activating enzyme (AAE) consensus motif; other site 768492005718 AMP binding site [chemical binding]; other site 768492005719 Phosphopantetheine attachment site; Region: PP-binding; cl09936 768492005720 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 768492005721 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768492005722 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492005723 catalytic residue [active] 768492005724 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 768492005725 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492005726 S-adenosylmethionine binding site [chemical binding]; other site 768492005727 Predicted dehydrogenase [General function prediction only]; Region: COG5322 768492005728 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 768492005729 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768492005730 inhibitor-cofactor binding pocket; inhibition site 768492005731 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492005732 catalytic residue [active] 768492005733 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 768492005734 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 768492005735 TPP-binding site [chemical binding]; other site 768492005736 phosphoenolpyruvate synthase; Validated; Region: PRK06241 768492005737 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 768492005738 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 768492005739 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 768492005740 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 768492005741 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 768492005742 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 768492005743 active site 768492005744 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 768492005745 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 768492005746 active site 768492005747 substrate binding site [chemical binding]; other site 768492005748 Mg2+ binding site [ion binding]; other site 768492005749 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 768492005750 LysE type translocator; Region: LysE; cl00565 768492005751 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 768492005752 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492005753 The C-terminal substrate binding domain of LysR-type transcriptional regulator TrpI, which is involved in control of tryptophan synthesis, contains type 2 periplasmic binding fold; Region: PBP2_TrpI; cd08482 768492005754 putative dimerization interface [polypeptide binding]; other site 768492005755 putative substrate binding pocket [chemical binding]; other site 768492005756 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768492005757 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492005758 non-specific DNA binding site [nucleotide binding]; other site 768492005759 salt bridge; other site 768492005760 sequence-specific DNA binding site [nucleotide binding]; other site 768492005761 Cupin domain; Region: Cupin_2; cl17218 768492005762 EamA-like transporter family; Region: EamA; pfam00892 768492005763 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 768492005764 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 768492005765 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 768492005766 pyrimidine utilization protein D; Region: RutD; TIGR03611 768492005767 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 768492005768 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 768492005769 homotrimer interaction site [polypeptide binding]; other site 768492005770 putative active site [active] 768492005771 Isochorismatase family; Region: Isochorismatase; pfam00857 768492005772 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 768492005773 catalytic triad [active] 768492005774 conserved cis-peptide bond; other site 768492005775 pyrimidine utilization protein A; Region: RutA; TIGR03612 768492005776 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 768492005777 active site 768492005778 dimer interface [polypeptide binding]; other site 768492005779 non-prolyl cis peptide bond; other site 768492005780 insertion regions; other site 768492005781 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 768492005782 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768492005783 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 768492005784 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 768492005785 TolA C-terminal; Region: TolA; pfam06519 768492005786 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 768492005787 Uncharacterized conserved protein [Function unknown]; Region: COG1359 768492005788 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768492005789 enoyl-CoA hydratase; Provisional; Region: PRK05870 768492005790 substrate binding site [chemical binding]; other site 768492005791 oxyanion hole (OAH) forming residues; other site 768492005792 trimer interface [polypeptide binding]; other site 768492005793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492005794 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768492005795 putative substrate translocation pore; other site 768492005796 5-aminolevulinate synthase; Validated; Region: PRK09064 768492005797 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 768492005798 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492005799 catalytic residue [active] 768492005800 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 768492005801 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 768492005802 dimer interface [polypeptide binding]; other site 768492005803 active site 768492005804 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 768492005805 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 768492005806 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768492005807 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768492005808 transcriptional regulator TraR; Provisional; Region: PRK13870 768492005809 Autoinducer binding domain; Region: Autoind_bind; pfam03472 768492005810 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492005811 DNA binding residues [nucleotide binding] 768492005812 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 768492005813 Ligand Binding Site [chemical binding]; other site 768492005814 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 768492005815 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 768492005816 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 768492005817 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 768492005818 dimer interface [polypeptide binding]; other site 768492005819 NADP binding site [chemical binding]; other site 768492005820 catalytic residues [active] 768492005821 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 768492005822 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 768492005823 inhibitor site; inhibition site 768492005824 active site 768492005825 dimer interface [polypeptide binding]; other site 768492005826 catalytic residue [active] 768492005827 PAS fold; Region: PAS_4; pfam08448 768492005828 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768492005829 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492005830 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 768492005831 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 768492005832 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 768492005833 hydroxyglutarate oxidase; Provisional; Region: PRK11728 768492005834 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 768492005835 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 768492005836 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 768492005837 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 768492005838 GlpM protein; Region: GlpM; pfam06942 768492005839 hypothetical protein; Provisional; Region: PRK10613 768492005840 response regulator; Provisional; Region: PRK09483 768492005841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492005842 active site 768492005843 phosphorylation site [posttranslational modification] 768492005844 intermolecular recognition site; other site 768492005845 dimerization interface [polypeptide binding]; other site 768492005846 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492005847 DNA binding residues [nucleotide binding] 768492005848 dimerization interface [polypeptide binding]; other site 768492005849 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 768492005850 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 768492005851 GIY-YIG motif/motif A; other site 768492005852 active site 768492005853 catalytic site [active] 768492005854 putative DNA binding site [nucleotide binding]; other site 768492005855 metal binding site [ion binding]; metal-binding site 768492005856 UvrB/uvrC motif; Region: UVR; pfam02151 768492005857 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 768492005858 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 768492005859 phosphoethanolamine transferase; Provisional; Region: PRK11560 768492005860 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 768492005861 Sulfatase; Region: Sulfatase; pfam00884 768492005862 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 768492005863 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 768492005864 proline/glycine betaine transporter; Provisional; Region: PRK10642 768492005865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492005866 putative substrate translocation pore; other site 768492005867 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 768492005868 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 768492005869 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 768492005870 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768492005871 Walker A/P-loop; other site 768492005872 ATP binding site [chemical binding]; other site 768492005873 Q-loop/lid; other site 768492005874 ABC transporter signature motif; other site 768492005875 Walker B; other site 768492005876 D-loop; other site 768492005877 H-loop/switch region; other site 768492005878 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768492005879 FtsX-like permease family; Region: FtsX; pfam02687 768492005880 macrolide transporter subunit MacA; Provisional; Region: PRK11578 768492005881 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768492005882 HlyD family secretion protein; Region: HlyD_3; pfam13437 768492005883 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 768492005884 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 768492005885 GIY-YIG motif/motif A; other site 768492005886 active site 768492005887 catalytic site [active] 768492005888 putative DNA binding site [nucleotide binding]; other site 768492005889 metal binding site [ion binding]; metal-binding site 768492005890 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 768492005891 potassium/proton antiporter; Reviewed; Region: PRK05326 768492005892 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 768492005893 TrkA-C domain; Region: TrkA_C; pfam02080 768492005894 Transporter associated domain; Region: CorC_HlyC; smart01091 768492005895 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 768492005896 Acyltransferase family; Region: Acyl_transf_3; pfam01757 768492005897 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 768492005898 Acyltransferase family; Region: Acyl_transf_3; pfam01757 768492005899 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 768492005900 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 768492005901 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 768492005902 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 768492005903 Ligand binding site; other site 768492005904 DXD motif; other site 768492005905 lipoprotein; Provisional; Region: PRK10175 768492005906 MsyB protein; Region: MsyB; cl08181 768492005907 2-isopropylmalate synthase; Validated; Region: PRK03739 768492005908 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 768492005909 active site 768492005910 catalytic residues [active] 768492005911 metal binding site [ion binding]; metal-binding site 768492005912 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 768492005913 Cupin domain; Region: Cupin_2; cl17218 768492005914 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768492005915 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492005916 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768492005917 dimerization interface [polypeptide binding]; other site 768492005918 putative DNA binding site [nucleotide binding]; other site 768492005919 putative Zn2+ binding site [ion binding]; other site 768492005920 Predicted transporter component [General function prediction only]; Region: COG2391 768492005921 Sulphur transport; Region: Sulf_transp; pfam04143 768492005922 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768492005923 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 768492005924 active site 768492005925 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 768492005926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492005927 putative substrate translocation pore; other site 768492005928 POT family; Region: PTR2; cl17359 768492005929 drug efflux system protein MdtG; Provisional; Region: PRK09874 768492005930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492005931 putative substrate translocation pore; other site 768492005932 YCII-related domain; Region: YCII; cl00999 768492005933 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 768492005934 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 768492005935 putative acyl-acceptor binding pocket; other site 768492005936 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 768492005937 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 768492005938 active site 768492005939 FMN binding site [chemical binding]; other site 768492005940 substrate binding site [chemical binding]; other site 768492005941 homotetramer interface [polypeptide binding]; other site 768492005942 catalytic residue [active] 768492005943 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 768492005944 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 768492005945 active site residue [active] 768492005946 YceI-like domain; Region: YceI; cl01001 768492005947 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 768492005948 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 768492005949 Domain of unknown function DUF20; Region: UPF0118; pfam01594 768492005950 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 768492005951 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492005952 DNA binding residues [nucleotide binding] 768492005953 dimerization interface [polypeptide binding]; other site 768492005954 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 768492005955 hydroxyglutarate oxidase; Provisional; Region: PRK11728 768492005956 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 768492005957 DNA damage-inducible protein I; Provisional; Region: PRK10597 768492005958 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 768492005959 active site 768492005960 substrate binding pocket [chemical binding]; other site 768492005961 dimer interface [polypeptide binding]; other site 768492005962 Uncharacterized conserved protein [Function unknown]; Region: COG1359 768492005963 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 768492005964 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 768492005965 homodimer interface [polypeptide binding]; other site 768492005966 oligonucleotide binding site [chemical binding]; other site 768492005967 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 768492005968 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 768492005969 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768492005970 RNA binding surface [nucleotide binding]; other site 768492005971 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 768492005972 active site 768492005973 Maf-like protein; Region: Maf; pfam02545 768492005974 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 768492005975 active site 768492005976 dimer interface [polypeptide binding]; other site 768492005977 hypothetical protein; Provisional; Region: PRK11193 768492005978 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 768492005979 putative phosphate acyltransferase; Provisional; Region: PRK05331 768492005980 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 768492005981 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 768492005982 dimer interface [polypeptide binding]; other site 768492005983 active site 768492005984 CoA binding pocket [chemical binding]; other site 768492005985 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 768492005986 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 768492005987 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 768492005988 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 768492005989 NAD(P) binding site [chemical binding]; other site 768492005990 homotetramer interface [polypeptide binding]; other site 768492005991 homodimer interface [polypeptide binding]; other site 768492005992 active site 768492005993 acyl carrier protein; Provisional; Region: acpP; PRK00982 768492005994 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 768492005995 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 768492005996 dimer interface [polypeptide binding]; other site 768492005997 active site 768492005998 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 768492005999 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 768492006000 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492006001 catalytic residue [active] 768492006002 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 768492006003 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 768492006004 dimerization interface [polypeptide binding]; other site 768492006005 thymidylate kinase; Validated; Region: tmk; PRK00698 768492006006 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 768492006007 TMP-binding site; other site 768492006008 ATP-binding site [chemical binding]; other site 768492006009 DNA polymerase III subunit delta'; Validated; Region: PRK07993 768492006010 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 768492006011 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 768492006012 active site 768492006013 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 768492006014 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768492006015 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768492006016 active site turn [active] 768492006017 phosphorylation site [posttranslational modification] 768492006018 manganese transport regulator MntR; Provisional; Region: PRK11050 768492006019 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768492006020 putative DNA binding site [nucleotide binding]; other site 768492006021 putative Zn2+ binding site [ion binding]; other site 768492006022 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 768492006023 manganese transport protein MntH; Reviewed; Region: PRK00701 768492006024 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 768492006025 Bacterial SH3 domain homologues; Region: SH3b; smart00287 768492006026 short chain dehydrogenase; Provisional; Region: PRK06500 768492006027 classical (c) SDRs; Region: SDR_c; cd05233 768492006028 NAD(P) binding site [chemical binding]; other site 768492006029 active site 768492006030 Predicted transcriptional regulators [Transcription]; Region: COG1733 768492006031 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 768492006032 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768492006033 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492006034 substrate binding pocket [chemical binding]; other site 768492006035 membrane-bound complex binding site; other site 768492006036 hinge residues; other site 768492006037 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 768492006038 nucleotide binding site/active site [active] 768492006039 HIT family signature motif; other site 768492006040 catalytic residue [active] 768492006041 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 768492006042 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 768492006043 putative dimer interface [polypeptide binding]; other site 768492006044 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 768492006045 thiamine kinase; Region: ycfN_thiK; TIGR02721 768492006046 active site 768492006047 substrate binding site [chemical binding]; other site 768492006048 ATP binding site [chemical binding]; other site 768492006049 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 768492006050 beta-hexosaminidase; Provisional; Region: PRK05337 768492006051 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 768492006052 hypothetical protein; Provisional; Region: PRK04940 768492006053 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 768492006054 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768492006055 hypothetical protein; Provisional; Region: PRK11280 768492006056 Predicted transcriptional regulator [Transcription]; Region: COG1959 768492006057 Transcriptional regulator; Region: Rrf2; pfam02082 768492006058 Transcriptional regulator; Region: Rrf2; cl17282 768492006059 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 768492006060 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 768492006061 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768492006062 HlyD family secretion protein; Region: HlyD_3; pfam13437 768492006063 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 768492006064 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492006065 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492006066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492006067 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 768492006068 POT family; Region: PTR2; cl17359 768492006069 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 768492006070 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 768492006071 putative ligand binding site [chemical binding]; other site 768492006072 NAD binding site [chemical binding]; other site 768492006073 dimerization interface [polypeptide binding]; other site 768492006074 catalytic site [active] 768492006075 putative hydrolase; Validated; Region: PRK09248 768492006076 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 768492006077 active site 768492006078 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 768492006079 Protein of unknown function (DUF533); Region: DUF533; pfam04391 768492006080 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 768492006081 putative metal binding site [ion binding]; other site 768492006082 protease 2; Provisional; Region: PRK10115 768492006083 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 768492006084 exodeoxyribonuclease X; Provisional; Region: PRK07983 768492006085 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 768492006086 active site 768492006087 catalytic site [active] 768492006088 substrate binding site [chemical binding]; other site 768492006089 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 768492006090 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 768492006091 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 768492006092 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 768492006093 Ferritin-like domain; Region: Ferritin; pfam00210 768492006094 ferroxidase diiron center [ion binding]; other site 768492006095 CopC domain; Region: CopC; cl01012 768492006096 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 768492006097 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 768492006098 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768492006099 Isochorismatase family; Region: Isochorismatase; pfam00857 768492006100 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 768492006101 catalytic triad [active] 768492006102 conserved cis-peptide bond; other site 768492006103 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 768492006104 putative transposase OrfB; Reviewed; Region: PHA02517 768492006105 Integrase core domain; Region: rve; pfam00665 768492006106 Integrase core domain; Region: rve_3; pfam13683 768492006107 Homeodomain-like domain; Region: HTH_23; cl17451 768492006108 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 768492006109 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 768492006110 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 768492006111 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 768492006112 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 768492006113 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492006114 salt bridge; other site 768492006115 non-specific DNA binding site [nucleotide binding]; other site 768492006116 sequence-specific DNA binding site [nucleotide binding]; other site 768492006117 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492006118 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492006119 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492006120 dimerization interface [polypeptide binding]; other site 768492006121 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 768492006122 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 768492006123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492006124 active site 768492006125 phosphorylation site [posttranslational modification] 768492006126 intermolecular recognition site; other site 768492006127 dimerization interface [polypeptide binding]; other site 768492006128 sensory histidine kinase DcuS; Provisional; Region: PRK11086 768492006129 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492006130 ATP binding site [chemical binding]; other site 768492006131 Mg2+ binding site [ion binding]; other site 768492006132 G-X-G motif; other site 768492006133 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 768492006134 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 768492006135 putative active site; other site 768492006136 catalytic residue [active] 768492006137 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 768492006138 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 768492006139 putative ligand binding site [chemical binding]; other site 768492006140 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 768492006141 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768492006142 Walker A/P-loop; other site 768492006143 ATP binding site [chemical binding]; other site 768492006144 Q-loop/lid; other site 768492006145 ABC transporter signature motif; other site 768492006146 Walker B; other site 768492006147 D-loop; other site 768492006148 H-loop/switch region; other site 768492006149 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768492006150 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768492006151 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768492006152 TM-ABC transporter signature motif; other site 768492006153 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 768492006154 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 768492006155 putative ligand binding site [chemical binding]; other site 768492006156 Right handed beta helix region; Region: Beta_helix; pfam13229 768492006157 Right handed beta helix region; Region: Beta_helix; pfam13229 768492006158 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 768492006159 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 768492006160 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 768492006161 Ligand Binding Site [chemical binding]; other site 768492006162 putative kinase; Provisional; Region: PRK09954 768492006163 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768492006164 putative DNA binding site [nucleotide binding]; other site 768492006165 putative Zn2+ binding site [ion binding]; other site 768492006166 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 768492006167 substrate binding site [chemical binding]; other site 768492006168 ATP binding site [chemical binding]; other site 768492006169 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 768492006170 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 768492006171 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 768492006172 Nucleoside recognition; Region: Gate; pfam07670 768492006173 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 768492006174 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 768492006175 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768492006176 dimerization interface [polypeptide binding]; other site 768492006177 putative DNA binding site [nucleotide binding]; other site 768492006178 putative Zn2+ binding site [ion binding]; other site 768492006179 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 768492006180 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 768492006181 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 768492006182 oligomer interface [polypeptide binding]; other site 768492006183 active site residues [active] 768492006184 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768492006185 PAS domain; Region: PAS_9; pfam13426 768492006186 putative active site [active] 768492006187 heme pocket [chemical binding]; other site 768492006188 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768492006189 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768492006190 metal binding site [ion binding]; metal-binding site 768492006191 active site 768492006192 I-site; other site 768492006193 GTP-binding protein YchF; Reviewed; Region: PRK09601 768492006194 YchF GTPase; Region: YchF; cd01900 768492006195 G1 box; other site 768492006196 GTP/Mg2+ binding site [chemical binding]; other site 768492006197 Switch I region; other site 768492006198 G2 box; other site 768492006199 Switch II region; other site 768492006200 G3 box; other site 768492006201 G4 box; other site 768492006202 G5 box; other site 768492006203 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 768492006204 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 768492006205 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 768492006206 Sulfate transporter family; Region: Sulfate_transp; pfam00916 768492006207 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 768492006208 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 768492006209 putative active site [active] 768492006210 catalytic residue [active] 768492006211 hypothetical protein; Provisional; Region: PRK10692 768492006212 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 768492006213 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 768492006214 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768492006215 active site 768492006216 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 768492006217 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 768492006218 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 768492006219 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 768492006220 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 768492006221 Chitin binding domain; Region: Chitin_bind_3; cl03871 768492006222 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 768492006223 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 768492006224 tRNA; other site 768492006225 putative tRNA binding site [nucleotide binding]; other site 768492006226 putative NADP binding site [chemical binding]; other site 768492006227 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 768492006228 peptide chain release factor 1; Validated; Region: prfA; PRK00591 768492006229 This domain is found in peptide chain release factors; Region: PCRF; smart00937 768492006230 RF-1 domain; Region: RF-1; pfam00472 768492006231 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 768492006232 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492006233 Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247 768492006234 hypothetical protein; Provisional; Region: PRK10941 768492006235 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 768492006236 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 768492006237 TPR motif; other site 768492006238 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 768492006239 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 768492006240 putative transporter; Provisional; Region: PRK11660 768492006241 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 768492006242 Sulfate transporter family; Region: Sulfate_transp; pfam00916 768492006243 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 768492006244 hypothetical protein; Provisional; Region: PRK02487 768492006245 transcription-repair coupling factor; Provisional; Region: PRK10689 768492006246 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 768492006247 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768492006248 ATP binding site [chemical binding]; other site 768492006249 putative Mg++ binding site [ion binding]; other site 768492006250 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768492006251 nucleotide binding region [chemical binding]; other site 768492006252 ATP-binding site [chemical binding]; other site 768492006253 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 768492006254 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 768492006255 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 768492006256 tetramer interface [polypeptide binding]; other site 768492006257 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492006258 catalytic residue [active] 768492006259 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 768492006260 YheO-like PAS domain; Region: PAS_6; pfam08348 768492006261 HTH domain; Region: HTH_22; pfam13309 768492006262 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 768492006263 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768492006264 FtsX-like permease family; Region: FtsX; pfam02687 768492006265 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 768492006266 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768492006267 Walker A/P-loop; other site 768492006268 ATP binding site [chemical binding]; other site 768492006269 Q-loop/lid; other site 768492006270 ABC transporter signature motif; other site 768492006271 Walker B; other site 768492006272 D-loop; other site 768492006273 H-loop/switch region; other site 768492006274 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 768492006275 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768492006276 FtsX-like permease family; Region: FtsX; pfam02687 768492006277 fructokinase; Reviewed; Region: PRK09557 768492006278 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768492006279 nucleotide binding site [chemical binding]; other site 768492006280 NAD-dependent deacetylase; Provisional; Region: PRK00481 768492006281 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 768492006282 NAD+ binding site [chemical binding]; other site 768492006283 substrate binding site [chemical binding]; other site 768492006284 Zn binding site [ion binding]; other site 768492006285 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 768492006286 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768492006287 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768492006288 putative active site [active] 768492006289 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 768492006290 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 768492006291 NAD(P) binding site [chemical binding]; other site 768492006292 LDH/MDH dimer interface [polypeptide binding]; other site 768492006293 substrate binding site [chemical binding]; other site 768492006294 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768492006295 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 768492006296 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768492006297 active site turn [active] 768492006298 phosphorylation site [posttranslational modification] 768492006299 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 768492006300 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 768492006301 metal binding site [ion binding]; metal-binding site 768492006302 dimer interface [polypeptide binding]; other site 768492006303 putative dehydrogenase; Provisional; Region: PRK10098 768492006304 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 768492006305 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768492006306 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492006307 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492006308 dimerization interface [polypeptide binding]; other site 768492006309 Uncharacterized conserved protein [Function unknown]; Region: COG2850 768492006310 Cupin domain; Region: Cupin_2; cl17218 768492006311 sensor protein PhoQ; Provisional; Region: PRK10815 768492006312 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 768492006313 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 768492006314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492006315 ATP binding site [chemical binding]; other site 768492006316 Mg2+ binding site [ion binding]; other site 768492006317 G-X-G motif; other site 768492006318 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 768492006319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492006320 active site 768492006321 phosphorylation site [posttranslational modification] 768492006322 intermolecular recognition site; other site 768492006323 dimerization interface [polypeptide binding]; other site 768492006324 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768492006325 DNA binding site [nucleotide binding] 768492006326 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768492006327 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492006328 DNA-binding site [nucleotide binding]; DNA binding site 768492006329 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492006330 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492006331 homodimer interface [polypeptide binding]; other site 768492006332 catalytic residue [active] 768492006333 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768492006334 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492006335 Coenzyme A binding pocket [chemical binding]; other site 768492006336 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 768492006337 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768492006338 adenylosuccinate lyase; Provisional; Region: PRK09285 768492006339 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 768492006340 tetramer interface [polypeptide binding]; other site 768492006341 active site 768492006342 putative lysogenization regulator; Reviewed; Region: PRK00218 768492006343 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 768492006344 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 768492006345 Ligand Binding Site [chemical binding]; other site 768492006346 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 768492006347 nudix motif; other site 768492006348 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 768492006349 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 768492006350 probable active site [active] 768492006351 isocitrate dehydrogenase; Validated; Region: PRK07362 768492006352 isocitrate dehydrogenase; Reviewed; Region: PRK07006 768492006353 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 768492006354 Autoinducer binding domain; Region: Autoind_bind; pfam03472 768492006355 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492006356 DNA binding residues [nucleotide binding] 768492006357 dimerization interface [polypeptide binding]; other site 768492006358 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 768492006359 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 768492006360 TolA C-terminal; Region: TolA; pfam06519 768492006361 Domain of unknown function DUF20; Region: UPF0118; pfam01594 768492006362 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 768492006363 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492006364 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768492006365 Coenzyme A binding pocket [chemical binding]; other site 768492006366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492006367 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768492006368 putative substrate translocation pore; other site 768492006369 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 768492006370 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492006371 DNA binding site [nucleotide binding] 768492006372 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 768492006373 putative ligand binding site [chemical binding]; other site 768492006374 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 768492006375 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768492006376 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768492006377 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 768492006378 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 768492006379 Protein of unknown function; Region: DUF3658; pfam12395 768492006380 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 768492006381 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 768492006382 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 768492006383 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 768492006384 LysE type translocator; Region: LysE; cl00565 768492006385 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768492006386 DNA-binding site [nucleotide binding]; DNA binding site 768492006387 RNA-binding motif; other site 768492006388 short chain dehydrogenase; Provisional; Region: PRK06138 768492006389 classical (c) SDRs; Region: SDR_c; cd05233 768492006390 NAD(P) binding site [chemical binding]; other site 768492006391 active site 768492006392 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 768492006393 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 768492006394 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 768492006395 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 768492006396 NAD(P) binding site [chemical binding]; other site 768492006397 catalytic residues [active] 768492006398 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 768492006399 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492006400 non-specific DNA binding site [nucleotide binding]; other site 768492006401 salt bridge; other site 768492006402 sequence-specific DNA binding site [nucleotide binding]; other site 768492006403 Cupin domain; Region: Cupin_2; pfam07883 768492006404 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 768492006405 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 768492006406 catalytic triad [active] 768492006407 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 768492006408 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 768492006409 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 768492006410 aromatic amino acid exporter; Provisional; Region: PRK11689 768492006411 EamA-like transporter family; Region: EamA; pfam00892 768492006412 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 768492006413 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 768492006414 chorismate mutase; Provisional; Region: PRK08055 768492006415 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 768492006416 Beta-lactamase; Region: Beta-lactamase; pfam00144 768492006417 N-formylglutamate amidohydrolase; Region: FGase; cl01522 768492006418 imidazolonepropionase; Validated; Region: PRK09356 768492006419 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 768492006420 active site 768492006421 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 768492006422 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492006423 DNA-binding site [nucleotide binding]; DNA binding site 768492006424 UTRA domain; Region: UTRA; pfam07702 768492006425 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 768492006426 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 768492006427 active site 768492006428 HutD; Region: HutD; pfam05962 768492006429 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 768492006430 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 768492006431 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 768492006432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492006433 dimer interface [polypeptide binding]; other site 768492006434 conserved gate region; other site 768492006435 putative PBP binding loops; other site 768492006436 ABC-ATPase subunit interface; other site 768492006437 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 768492006438 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 768492006439 Walker A/P-loop; other site 768492006440 ATP binding site [chemical binding]; other site 768492006441 Q-loop/lid; other site 768492006442 ABC transporter signature motif; other site 768492006443 Walker B; other site 768492006444 D-loop; other site 768492006445 H-loop/switch region; other site 768492006446 histidinol-phosphate aminotransferase; Provisional; Region: PRK05166 768492006447 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492006448 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492006449 homodimer interface [polypeptide binding]; other site 768492006450 catalytic residue [active] 768492006451 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 768492006452 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 768492006453 phosphate binding site [ion binding]; other site 768492006454 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768492006455 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492006456 DNA binding site [nucleotide binding] 768492006457 domain linker motif; other site 768492006458 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 768492006459 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 768492006460 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 768492006461 substrate binding [chemical binding]; other site 768492006462 active site 768492006463 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 768492006464 galactoside permease; Reviewed; Region: lacY; PRK09528 768492006465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492006466 putative substrate translocation pore; other site 768492006467 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492006468 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 768492006469 NAD(P) binding site [chemical binding]; other site 768492006470 active site 768492006471 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 768492006472 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 768492006473 NAD binding site [chemical binding]; other site 768492006474 dimerization interface [polypeptide binding]; other site 768492006475 product binding site; other site 768492006476 substrate binding site [chemical binding]; other site 768492006477 zinc binding site [ion binding]; other site 768492006478 catalytic residues [active] 768492006479 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 768492006480 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 768492006481 Walker A/P-loop; other site 768492006482 ATP binding site [chemical binding]; other site 768492006483 Q-loop/lid; other site 768492006484 ABC transporter signature motif; other site 768492006485 Walker B; other site 768492006486 D-loop; other site 768492006487 H-loop/switch region; other site 768492006488 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 768492006489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492006490 dimer interface [polypeptide binding]; other site 768492006491 conserved gate region; other site 768492006492 putative PBP binding loops; other site 768492006493 ABC-ATPase subunit interface; other site 768492006494 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 768492006495 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492006496 substrate binding pocket [chemical binding]; other site 768492006497 membrane-bound complex binding site; other site 768492006498 hinge residues; other site 768492006499 metabolite-proton symporter; Region: 2A0106; TIGR00883 768492006500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492006501 putative substrate translocation pore; other site 768492006502 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492006503 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768492006504 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492006505 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492006506 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 768492006507 putative effector binding pocket; other site 768492006508 putative dimerization interface [polypeptide binding]; other site 768492006509 hypothetical protein; Provisional; Region: PRK08204 768492006510 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 768492006511 active site 768492006512 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 768492006513 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 768492006514 active site 768492006515 substrate-binding site [chemical binding]; other site 768492006516 metal-binding site [ion binding] 768492006517 ATP binding site [chemical binding]; other site 768492006518 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 768492006519 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 768492006520 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 768492006521 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 768492006522 Spore Coat Protein U domain; Region: SCPU; pfam05229 768492006523 Uncharacterized secreted protein [Function unknown]; Region: COG5430 768492006524 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 768492006525 PapC N-terminal domain; Region: PapC_N; pfam13954 768492006526 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 768492006527 PapC C-terminal domain; Region: PapC_C; pfam13953 768492006528 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 768492006529 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 768492006530 Spore Coat Protein U domain; Region: SCPU; pfam05229 768492006531 Spore Coat Protein U domain; Region: SCPU; pfam05229 768492006532 Spore Coat Protein U domain; Region: SCPU; pfam05229 768492006533 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 768492006534 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492006535 S-adenosylmethionine binding site [chemical binding]; other site 768492006536 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 768492006537 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 768492006538 mce related protein; Region: MCE; pfam02470 768492006539 mce related protein; Region: MCE; pfam02470 768492006540 mce related protein; Region: MCE; pfam02470 768492006541 mce related protein; Region: MCE; pfam02470 768492006542 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 768492006543 mce related protein; Region: MCE; pfam02470 768492006544 mce related protein; Region: MCE; pfam02470 768492006545 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 768492006546 Paraquat-inducible protein A; Region: PqiA; pfam04403 768492006547 Paraquat-inducible protein A; Region: PqiA; pfam04403 768492006548 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 768492006549 GAF domain; Region: GAF_2; pfam13185 768492006550 ProP expression regulator; Provisional; Region: PRK04950 768492006551 ProQ/FINO family; Region: ProQ; pfam04352 768492006552 putative RNA binding sites [nucleotide binding]; other site 768492006553 carboxy-terminal protease; Provisional; Region: PRK11186 768492006554 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 768492006555 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 768492006556 protein binding site [polypeptide binding]; other site 768492006557 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 768492006558 Catalytic dyad [active] 768492006559 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 768492006560 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 768492006561 heat shock protein HtpX; Provisional; Region: PRK05457 768492006562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492006563 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768492006564 putative substrate translocation pore; other site 768492006565 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 768492006566 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 768492006567 Bacterial transcriptional regulator; Region: IclR; pfam01614 768492006568 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 768492006569 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 768492006570 inner membrane protein; Provisional; Region: PRK11648 768492006571 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 768492006572 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492006573 motif II; other site 768492006574 YniB-like protein; Region: YniB; pfam14002 768492006575 Fructosamine kinase; Region: Fructosamin_kin; pfam03881 768492006576 Phosphotransferase enzyme family; Region: APH; pfam01636 768492006577 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492006578 Coenzyme A binding pocket [chemical binding]; other site 768492006579 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 768492006580 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768492006581 ABC-ATPase subunit interface; other site 768492006582 dimer interface [polypeptide binding]; other site 768492006583 putative PBP binding regions; other site 768492006584 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 768492006585 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768492006586 ABC-ATPase subunit interface; other site 768492006587 dimer interface [polypeptide binding]; other site 768492006588 putative PBP binding regions; other site 768492006589 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 768492006590 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 768492006591 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 768492006592 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 768492006593 metal binding site [ion binding]; metal-binding site 768492006594 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 768492006595 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 768492006596 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768492006597 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768492006598 catalytic residue [active] 768492006599 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 768492006600 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 768492006601 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 768492006602 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 768492006603 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768492006604 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768492006605 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 768492006606 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 768492006607 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 768492006608 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 768492006609 intersubunit interface [polypeptide binding]; other site 768492006610 inner membrane protein; Provisional; Region: PRK10995 768492006611 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 768492006612 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 768492006613 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 768492006614 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 768492006615 active site 768492006616 dimer interface [polypeptide binding]; other site 768492006617 motif 1; other site 768492006618 motif 2; other site 768492006619 motif 3; other site 768492006620 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 768492006621 anticodon binding site; other site 768492006622 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 768492006623 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 768492006624 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 768492006625 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 768492006626 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 768492006627 23S rRNA binding site [nucleotide binding]; other site 768492006628 L21 binding site [polypeptide binding]; other site 768492006629 L13 binding site [polypeptide binding]; other site 768492006630 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 768492006631 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 768492006632 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 768492006633 dimer interface [polypeptide binding]; other site 768492006634 motif 1; other site 768492006635 active site 768492006636 motif 2; other site 768492006637 motif 3; other site 768492006638 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 768492006639 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 768492006640 putative tRNA-binding site [nucleotide binding]; other site 768492006641 B3/4 domain; Region: B3_4; pfam03483 768492006642 tRNA synthetase B5 domain; Region: B5; smart00874 768492006643 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 768492006644 dimer interface [polypeptide binding]; other site 768492006645 motif 1; other site 768492006646 motif 3; other site 768492006647 motif 2; other site 768492006648 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 768492006649 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 768492006650 IHF dimer interface [polypeptide binding]; other site 768492006651 IHF - DNA interface [nucleotide binding]; other site 768492006652 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 768492006653 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 768492006654 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768492006655 dimer interface [polypeptide binding]; other site 768492006656 putative PBP binding regions; other site 768492006657 ABC-ATPase subunit interface; other site 768492006658 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 768492006659 catalytic residues [active] 768492006660 dimer interface [polypeptide binding]; other site 768492006661 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 768492006662 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768492006663 Walker A/P-loop; other site 768492006664 ATP binding site [chemical binding]; other site 768492006665 Q-loop/lid; other site 768492006666 ABC transporter signature motif; other site 768492006667 Walker B; other site 768492006668 D-loop; other site 768492006669 H-loop/switch region; other site 768492006670 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 768492006671 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 768492006672 inhibitor-cofactor binding pocket; inhibition site 768492006673 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492006674 catalytic residue [active] 768492006675 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 768492006676 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 768492006677 Ligand binding site; other site 768492006678 Putative Catalytic site; other site 768492006679 DXD motif; other site 768492006680 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 768492006681 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 768492006682 active site 768492006683 substrate binding site [chemical binding]; other site 768492006684 cosubstrate binding site; other site 768492006685 catalytic site [active] 768492006686 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 768492006687 active site 768492006688 hexamer interface [polypeptide binding]; other site 768492006689 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 768492006690 NAD binding site [chemical binding]; other site 768492006691 substrate binding site [chemical binding]; other site 768492006692 active site 768492006693 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 768492006694 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 768492006695 putative active site [active] 768492006696 putative catalytic site [active] 768492006697 putative Zn binding site [ion binding]; other site 768492006698 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 768492006699 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 768492006700 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 768492006701 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 768492006702 NlpC/P60 family; Region: NLPC_P60; pfam00877 768492006703 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 768492006704 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 768492006705 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 768492006706 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768492006707 Uncharacterized conserved protein [Function unknown]; Region: COG0397 768492006708 hypothetical protein; Validated; Region: PRK00029 768492006709 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 768492006710 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768492006711 Walker A/P-loop; other site 768492006712 ATP binding site [chemical binding]; other site 768492006713 Q-loop/lid; other site 768492006714 ABC transporter signature motif; other site 768492006715 Walker B; other site 768492006716 D-loop; other site 768492006717 H-loop/switch region; other site 768492006718 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 768492006719 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768492006720 ABC-ATPase subunit interface; other site 768492006721 dimer interface [polypeptide binding]; other site 768492006722 putative PBP binding regions; other site 768492006723 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 768492006724 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 768492006725 putative hemin binding site; other site 768492006726 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 768492006727 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 768492006728 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 768492006729 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 768492006730 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768492006731 N-terminal plug; other site 768492006732 ligand-binding site [chemical binding]; other site 768492006733 Hemin uptake protein hemP; Region: hemP; pfam10636 768492006734 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 768492006735 catalytic residues [active] 768492006736 dimer interface [polypeptide binding]; other site 768492006737 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 768492006738 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 768492006739 PEP synthetase regulatory protein; Provisional; Region: PRK05339 768492006740 phosphoenolpyruvate synthase; Validated; Region: PRK06464 768492006741 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 768492006742 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 768492006743 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 768492006744 putative inner membrane protein; Provisional; Region: PRK10983 768492006745 Domain of unknown function DUF20; Region: UPF0118; pfam01594 768492006746 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 768492006747 FAD binding domain; Region: FAD_binding_4; pfam01565 768492006748 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 768492006749 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 768492006750 CoenzymeA binding site [chemical binding]; other site 768492006751 subunit interaction site [polypeptide binding]; other site 768492006752 PHB binding site; other site 768492006753 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 768492006754 putative ABC transporter; Region: ycf24; CHL00085 768492006755 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 768492006756 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 768492006757 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 768492006758 Walker A/P-loop; other site 768492006759 ATP binding site [chemical binding]; other site 768492006760 Q-loop/lid; other site 768492006761 ABC transporter signature motif; other site 768492006762 Walker B; other site 768492006763 D-loop; other site 768492006764 H-loop/switch region; other site 768492006765 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 768492006766 FeS assembly protein SufD; Region: sufD; TIGR01981 768492006767 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 768492006768 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 768492006769 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492006770 catalytic residue [active] 768492006771 cysteine desufuration protein SufE; Provisional; Region: PRK09296 768492006772 L,D-transpeptidase; Provisional; Region: PRK10190 768492006773 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768492006774 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 768492006775 murein lipoprotein; Provisional; Region: PRK15396 768492006776 pyruvate kinase; Provisional; Region: PRK09206 768492006777 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 768492006778 domain interfaces; other site 768492006779 active site 768492006780 Cupin domain; Region: Cupin_2; cl17218 768492006781 multidrug efflux protein; Reviewed; Region: PRK01766 768492006782 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 768492006783 cation binding site [ion binding]; other site 768492006784 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 768492006785 Lumazine binding domain; Region: Lum_binding; pfam00677 768492006786 Lumazine binding domain; Region: Lum_binding; pfam00677 768492006787 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 768492006788 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 768492006789 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 768492006790 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492006791 S-adenosylmethionine binding site [chemical binding]; other site 768492006792 putative transporter; Provisional; Region: PRK11043 768492006793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492006794 putative substrate translocation pore; other site 768492006795 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 768492006796 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492006797 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492006798 dimerization interface [polypeptide binding]; other site 768492006799 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 768492006800 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492006801 DNA binding site [nucleotide binding] 768492006802 domain linker motif; other site 768492006803 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 768492006804 dimerization interface [polypeptide binding]; other site 768492006805 ligand binding site [chemical binding]; other site 768492006806 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 768492006807 NlpC/P60 family; Region: NLPC_P60; pfam00877 768492006808 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 768492006809 putative GSH binding site [chemical binding]; other site 768492006810 catalytic residues [active] 768492006811 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 768492006812 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 768492006813 dimer interface [polypeptide binding]; other site 768492006814 catalytic site [active] 768492006815 putative active site [active] 768492006816 putative substrate binding site [chemical binding]; other site 768492006817 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768492006818 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 768492006819 dimer interface [polypeptide binding]; other site 768492006820 active site 768492006821 metal binding site [ion binding]; metal-binding site 768492006822 glutathione binding site [chemical binding]; other site 768492006823 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 768492006824 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 768492006825 active site 768492006826 metal binding site [ion binding]; metal-binding site 768492006827 nudix motif; other site 768492006828 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 768492006829 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 768492006830 FMN binding site [chemical binding]; other site 768492006831 active site 768492006832 substrate binding site [chemical binding]; other site 768492006833 catalytic residue [active] 768492006834 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492006835 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768492006836 putative metal dependent hydrolase; Provisional; Region: PRK11598 768492006837 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 768492006838 Sulfatase; Region: Sulfatase; pfam00884 768492006839 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 768492006840 NADH(P)-binding; Region: NAD_binding_10; pfam13460 768492006841 NAD binding site [chemical binding]; other site 768492006842 substrate binding site [chemical binding]; other site 768492006843 putative active site [active] 768492006844 transcriptional regulator; Provisional; Region: PRK10632 768492006845 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492006846 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492006847 putative effector binding pocket; other site 768492006848 dimerization interface [polypeptide binding]; other site 768492006849 Predicted Fe-S protein [General function prediction only]; Region: COG3313 768492006850 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768492006851 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768492006852 active site 768492006853 catalytic tetrad [active] 768492006854 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 768492006855 nucleophilic elbow; other site 768492006856 catalytic triad; other site 768492006857 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 768492006858 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 768492006859 E-class dimer interface [polypeptide binding]; other site 768492006860 P-class dimer interface [polypeptide binding]; other site 768492006861 active site 768492006862 Cu2+ binding site [ion binding]; other site 768492006863 Zn2+ binding site [ion binding]; other site 768492006864 Fusaric acid resistance protein family; Region: FUSC; pfam04632 768492006865 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 768492006866 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 768492006867 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768492006868 HlyD family secretion protein; Region: HlyD_3; pfam13437 768492006869 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 768492006870 transcriptional regulator SlyA; Provisional; Region: PRK03573 768492006871 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 768492006872 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 768492006873 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 768492006874 lysozyme inhibitor; Provisional; Region: PRK11372 768492006875 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 768492006876 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 768492006877 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 768492006878 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 768492006879 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 768492006880 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 768492006881 active site 768492006882 HIGH motif; other site 768492006883 dimer interface [polypeptide binding]; other site 768492006884 KMSKS motif; other site 768492006885 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768492006886 RNA binding surface [nucleotide binding]; other site 768492006887 pyridoxamine kinase; Validated; Region: PRK05756 768492006888 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 768492006889 dimer interface [polypeptide binding]; other site 768492006890 pyridoxal binding site [chemical binding]; other site 768492006891 ATP binding site [chemical binding]; other site 768492006892 glutathionine S-transferase; Provisional; Region: PRK10542 768492006893 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 768492006894 C-terminal domain interface [polypeptide binding]; other site 768492006895 GSH binding site (G-site) [chemical binding]; other site 768492006896 dimer interface [polypeptide binding]; other site 768492006897 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 768492006898 dimer interface [polypeptide binding]; other site 768492006899 N-terminal domain interface [polypeptide binding]; other site 768492006900 substrate binding pocket (H-site) [chemical binding]; other site 768492006901 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 768492006902 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 768492006903 dimer interface [polypeptide binding]; other site 768492006904 active site 768492006905 catalytic residue [active] 768492006906 YjbD family (DUF3811); Region: DUF3811; pfam11656 768492006907 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 768492006908 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768492006909 Zn2+ binding site [ion binding]; other site 768492006910 Mg2+ binding site [ion binding]; other site 768492006911 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 768492006912 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 768492006913 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 768492006914 homotrimer interaction site [polypeptide binding]; other site 768492006915 putative active site [active] 768492006916 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 768492006917 Cupin domain; Region: Cupin_2; cl17218 768492006918 MEKHLA domain; Region: MEKHLA; pfam08670 768492006919 benzoate transporter; Region: benE; TIGR00843 768492006920 Benzoate membrane transport protein; Region: BenE; pfam03594 768492006921 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 768492006922 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492006923 non-specific DNA binding site [nucleotide binding]; other site 768492006924 salt bridge; other site 768492006925 sequence-specific DNA binding site [nucleotide binding]; other site 768492006926 Cupin domain; Region: Cupin_2; pfam07883 768492006927 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 768492006928 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 768492006929 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 768492006930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492006931 putative substrate translocation pore; other site 768492006932 POT family; Region: PTR2; pfam00854 768492006933 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 768492006934 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 768492006935 putative symporter YagG; Provisional; Region: PRK09669 768492006936 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768492006937 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492006938 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492006939 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768492006940 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492006941 putative symporter YagG; Provisional; Region: PRK09669 768492006942 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 768492006943 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 768492006944 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 768492006945 inhibitor binding site; inhibition site 768492006946 active site 768492006947 endonuclease III; Provisional; Region: PRK10702 768492006948 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 768492006949 minor groove reading motif; other site 768492006950 helix-hairpin-helix signature motif; other site 768492006951 substrate binding pocket [chemical binding]; other site 768492006952 active site 768492006953 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 768492006954 electron transport complex RsxE subunit; Provisional; Region: PRK12405 768492006955 electron transport complex protein RnfG; Validated; Region: PRK01908 768492006956 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 768492006957 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 768492006958 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492006959 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 768492006960 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 768492006961 SLBB domain; Region: SLBB; pfam10531 768492006962 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768492006963 ferredoxin; Provisional; Region: PRK08764 768492006964 Putative Fe-S cluster; Region: FeS; cl17515 768492006965 4Fe-4S binding domain; Region: Fer4; pfam00037 768492006966 electron transport complex protein RsxA; Provisional; Region: PRK05151 768492006967 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 768492006968 L-arabinose isomerase; Provisional; Region: PRK02929 768492006969 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 768492006970 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 768492006971 trimer interface [polypeptide binding]; other site 768492006972 putative substrate binding site [chemical binding]; other site 768492006973 putative metal binding site [ion binding]; other site 768492006974 ribulokinase; Provisional; Region: PRK04123 768492006975 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 768492006976 N- and C-terminal domain interface [polypeptide binding]; other site 768492006977 active site 768492006978 MgATP binding site [chemical binding]; other site 768492006979 catalytic site [active] 768492006980 metal binding site [ion binding]; metal-binding site 768492006981 carbohydrate binding site [chemical binding]; other site 768492006982 homodimer interface [polypeptide binding]; other site 768492006983 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 768492006984 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 768492006985 ligand binding site [chemical binding]; other site 768492006986 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 768492006987 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768492006988 Walker A/P-loop; other site 768492006989 ATP binding site [chemical binding]; other site 768492006990 Q-loop/lid; other site 768492006991 ABC transporter signature motif; other site 768492006992 Walker B; other site 768492006993 D-loop; other site 768492006994 H-loop/switch region; other site 768492006995 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768492006996 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768492006997 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768492006998 TM-ABC transporter signature motif; other site 768492006999 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 768492007000 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768492007001 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492007002 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492007003 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 768492007004 substrate binding pocket [chemical binding]; other site 768492007005 substrate-Mg2+ binding site; other site 768492007006 aspartate-rich region 1; other site 768492007007 aspartate-rich region 2; other site 768492007008 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492007009 S-adenosylmethionine binding site [chemical binding]; other site 768492007010 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 768492007011 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 768492007012 TPP-binding site; other site 768492007013 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 768492007014 PYR/PP interface [polypeptide binding]; other site 768492007015 dimer interface [polypeptide binding]; other site 768492007016 TPP binding site [chemical binding]; other site 768492007017 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768492007018 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 768492007019 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 768492007020 active site 768492007021 metal binding site [ion binding]; metal-binding site 768492007022 nudix motif; other site 768492007023 putative oxidoreductase; Provisional; Region: PRK11579 768492007024 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768492007025 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 768492007026 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 768492007027 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 768492007028 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 768492007029 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 768492007030 active site 768492007031 purine riboside binding site [chemical binding]; other site 768492007032 AAA domain; Region: AAA_17; pfam13207 768492007033 AAA domain; Region: AAA_18; pfam13238 768492007034 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 768492007035 active site 768492007036 phosphorylation site [posttranslational modification] 768492007037 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 768492007038 intersubunit interface [polypeptide binding]; other site 768492007039 active site 768492007040 zinc binding site [ion binding]; other site 768492007041 Na+ binding site [ion binding]; other site 768492007042 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 768492007043 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 768492007044 active site 768492007045 P-loop; other site 768492007046 phosphorylation site [posttranslational modification] 768492007047 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 768492007048 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 768492007049 active site 768492007050 ADP/pyrophosphate binding site [chemical binding]; other site 768492007051 dimerization interface [polypeptide binding]; other site 768492007052 allosteric effector site; other site 768492007053 fructose-1,6-bisphosphate binding site; other site 768492007054 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 768492007055 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 768492007056 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 768492007057 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 768492007058 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 768492007059 dimer interface [polypeptide binding]; other site 768492007060 ADP-ribose binding site [chemical binding]; other site 768492007061 active site 768492007062 nudix motif; other site 768492007063 metal binding site [ion binding]; metal-binding site 768492007064 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 768492007065 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 768492007066 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492007067 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492007068 homodimer interface [polypeptide binding]; other site 768492007069 catalytic residue [active] 768492007070 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 768492007071 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 768492007072 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768492007073 active site turn [active] 768492007074 phosphorylation site [posttranslational modification] 768492007075 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 768492007076 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492007077 DNA binding site [nucleotide binding] 768492007078 domain linker motif; other site 768492007079 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 768492007080 putative dimerization interface [polypeptide binding]; other site 768492007081 putative ligand binding site [chemical binding]; other site 768492007082 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768492007083 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492007084 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492007085 dimerization interface [polypeptide binding]; other site 768492007086 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 768492007087 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 768492007088 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492007089 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492007090 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 768492007091 putative effector binding pocket; other site 768492007092 putative dimerization interface [polypeptide binding]; other site 768492007093 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 768492007094 Beta-lactamase; Region: Beta-lactamase; pfam00144 768492007095 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 768492007096 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 768492007097 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 768492007098 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 768492007099 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 768492007100 fumarate hydratase; Reviewed; Region: fumC; PRK00485 768492007101 Class II fumarases; Region: Fumarase_classII; cd01362 768492007102 active site 768492007103 tetramer interface [polypeptide binding]; other site 768492007104 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 768492007105 putative catalytic residues [active] 768492007106 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492007107 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492007108 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492007109 putative effector binding pocket; other site 768492007110 dimerization interface [polypeptide binding]; other site 768492007111 Predicted transcriptional regulator [Transcription]; Region: COG2378 768492007112 HTH domain; Region: HTH_11; pfam08279 768492007113 WYL domain; Region: WYL; pfam13280 768492007114 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768492007115 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 768492007116 putative dimer interface [polypeptide binding]; other site 768492007117 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 768492007118 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768492007119 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007120 putative substrate translocation pore; other site 768492007121 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 768492007122 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492007123 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 768492007124 dimerization interface [polypeptide binding]; other site 768492007125 substrate binding pocket [chemical binding]; other site 768492007126 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 768492007127 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 768492007128 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768492007129 nucleotide binding site [chemical binding]; other site 768492007130 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 768492007131 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 768492007132 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 768492007133 Cl- selectivity filter; other site 768492007134 Cl- binding residues [ion binding]; other site 768492007135 pore gating glutamate residue; other site 768492007136 dimer interface [polypeptide binding]; other site 768492007137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007138 putative substrate translocation pore; other site 768492007139 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 768492007140 hypothetical protein; Provisional; Region: PRK13659 768492007141 hypothetical protein; Provisional; Region: PRK02237 768492007142 malonic semialdehyde reductase; Provisional; Region: PRK10538 768492007143 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 768492007144 putative NAD(P) binding site [chemical binding]; other site 768492007145 homodimer interface [polypeptide binding]; other site 768492007146 homotetramer interface [polypeptide binding]; other site 768492007147 active site 768492007148 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768492007149 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 768492007150 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768492007151 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768492007152 active site 768492007153 catalytic tetrad [active] 768492007154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007155 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768492007156 putative substrate translocation pore; other site 768492007157 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 768492007158 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768492007159 Walker A/P-loop; other site 768492007160 ATP binding site [chemical binding]; other site 768492007161 Q-loop/lid; other site 768492007162 ABC transporter signature motif; other site 768492007163 Walker B; other site 768492007164 D-loop; other site 768492007165 H-loop/switch region; other site 768492007166 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 768492007167 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768492007168 substrate binding site [chemical binding]; other site 768492007169 ATP binding site [chemical binding]; other site 768492007170 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 768492007171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492007172 dimer interface [polypeptide binding]; other site 768492007173 conserved gate region; other site 768492007174 putative PBP binding loops; other site 768492007175 ABC-ATPase subunit interface; other site 768492007176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492007177 dimer interface [polypeptide binding]; other site 768492007178 conserved gate region; other site 768492007179 putative PBP binding loops; other site 768492007180 ABC-ATPase subunit interface; other site 768492007181 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 768492007182 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 768492007183 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 768492007184 non-specific DNA interactions [nucleotide binding]; other site 768492007185 DNA binding site [nucleotide binding] 768492007186 sequence specific DNA binding site [nucleotide binding]; other site 768492007187 putative cAMP binding site [chemical binding]; other site 768492007188 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 768492007189 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768492007190 nucleotide binding site [chemical binding]; other site 768492007191 Chitin binding domain; Region: Chitin_bind_3; pfam03067 768492007192 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 768492007193 Interdomain contacts; other site 768492007194 Cytokine receptor motif; other site 768492007195 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 768492007196 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 768492007197 Interdomain contacts; other site 768492007198 Cytokine receptor motif; other site 768492007199 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 768492007200 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 768492007201 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 768492007202 putative active site [active] 768492007203 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 768492007204 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 768492007205 Interdomain contacts; other site 768492007206 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 768492007207 guanine deaminase; Provisional; Region: PRK09228 768492007208 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 768492007209 active site 768492007210 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 768492007211 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768492007212 catalytic loop [active] 768492007213 iron binding site [ion binding]; other site 768492007214 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 768492007215 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 768492007216 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 768492007217 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 768492007218 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768492007219 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 768492007220 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 768492007221 XdhC Rossmann domain; Region: XdhC_C; pfam13478 768492007222 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 768492007223 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 768492007224 NAD binding site [chemical binding]; other site 768492007225 sugar binding site [chemical binding]; other site 768492007226 divalent metal binding site [ion binding]; other site 768492007227 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 768492007228 dimer interface [polypeptide binding]; other site 768492007229 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768492007230 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 768492007231 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768492007232 active site turn [active] 768492007233 phosphorylation site [posttranslational modification] 768492007234 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 768492007235 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492007236 DNA-binding site [nucleotide binding]; DNA binding site 768492007237 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 768492007238 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 768492007239 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 768492007240 Ca binding site [ion binding]; other site 768492007241 active site 768492007242 catalytic site [active] 768492007243 Cytochrome c; Region: Cytochrom_C; pfam00034 768492007244 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 768492007245 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 768492007246 active site 768492007247 Zn binding site [ion binding]; other site 768492007248 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 768492007249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007250 putative substrate translocation pore; other site 768492007251 Isochorismatase family; Region: Isochorismatase; pfam00857 768492007252 N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015 768492007253 catalytic triad [active] 768492007254 substrate binding site [chemical binding]; other site 768492007255 domain interfaces; other site 768492007256 conserved cis-peptide bond; other site 768492007257 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 768492007258 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768492007259 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 768492007260 catalytic site [active] 768492007261 hypothetical protein; Provisional; Region: PRK06847 768492007262 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 768492007263 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 768492007264 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768492007265 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 768492007266 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 768492007267 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 768492007268 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 768492007269 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768492007270 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 768492007271 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 768492007272 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768492007273 Cytochrome c; Region: Cytochrom_C; pfam00034 768492007274 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768492007275 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768492007276 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 768492007277 HlyD family secretion protein; Region: HlyD; pfam00529 768492007278 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768492007279 HlyD family secretion protein; Region: HlyD_3; pfam13437 768492007280 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 768492007281 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 768492007282 putative active site [active] 768492007283 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768492007284 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768492007285 Walker A/P-loop; other site 768492007286 ATP binding site [chemical binding]; other site 768492007287 Q-loop/lid; other site 768492007288 ABC transporter signature motif; other site 768492007289 Walker B; other site 768492007290 D-loop; other site 768492007291 H-loop/switch region; other site 768492007292 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 768492007293 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 768492007294 homodimer interface [polypeptide binding]; other site 768492007295 homotetramer interface [polypeptide binding]; other site 768492007296 active site pocket [active] 768492007297 cleavage site 768492007298 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 768492007299 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 768492007300 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768492007301 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 768492007302 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768492007303 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768492007304 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 768492007305 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768492007306 catalytic loop [active] 768492007307 iron binding site [ion binding]; other site 768492007308 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 768492007309 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768492007310 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768492007311 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 768492007312 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 768492007313 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768492007314 active site turn [active] 768492007315 phosphorylation site [posttranslational modification] 768492007316 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768492007317 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 768492007318 HPr interaction site; other site 768492007319 glycerol kinase (GK) interaction site [polypeptide binding]; other site 768492007320 active site 768492007321 phosphorylation site [posttranslational modification] 768492007322 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 768492007323 beta-galactosidase; Region: BGL; TIGR03356 768492007324 transcriptional antiterminator BglG; Provisional; Region: PRK09772 768492007325 CAT RNA binding domain; Region: CAT_RBD; smart01061 768492007326 PRD domain; Region: PRD; pfam00874 768492007327 PRD domain; Region: PRD; pfam00874 768492007328 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 768492007329 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492007330 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 768492007331 putative dimerization interface [polypeptide binding]; other site 768492007332 putative substrate binding pocket [chemical binding]; other site 768492007333 Chromate transporter; Region: Chromate_transp; pfam02417 768492007334 Chromate transporter; Region: Chromate_transp; pfam02417 768492007335 Protease inhibitor Inh; Region: Inh; pfam02974 768492007336 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 768492007337 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 768492007338 classical (c) SDRs; Region: SDR_c; cd05233 768492007339 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 768492007340 NAD(P) binding site [chemical binding]; other site 768492007341 active site 768492007342 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768492007343 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492007344 DNA binding site [nucleotide binding] 768492007345 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 768492007346 putative ligand binding site [chemical binding]; other site 768492007347 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 768492007348 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 768492007349 putative active site [active] 768492007350 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768492007351 EamA-like transporter family; Region: EamA; pfam00892 768492007352 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768492007353 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492007354 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 768492007355 active site 768492007356 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 768492007357 NIPSNAP; Region: NIPSNAP; pfam07978 768492007358 drug efflux system protein MdtG; Provisional; Region: PRK09874 768492007359 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007360 putative substrate translocation pore; other site 768492007361 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 768492007362 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 768492007363 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492007364 active site 768492007365 motif I; other site 768492007366 motif II; other site 768492007367 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 768492007368 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 768492007369 Coenzyme A binding pocket [chemical binding]; other site 768492007370 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 768492007371 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768492007372 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 768492007373 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 768492007374 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 768492007375 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 768492007376 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 768492007377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492007378 dimer interface [polypeptide binding]; other site 768492007379 conserved gate region; other site 768492007380 putative PBP binding loops; other site 768492007381 ABC-ATPase subunit interface; other site 768492007382 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 768492007383 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 768492007384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492007385 dimer interface [polypeptide binding]; other site 768492007386 conserved gate region; other site 768492007387 putative PBP binding loops; other site 768492007388 ABC-ATPase subunit interface; other site 768492007389 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 768492007390 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768492007391 Walker A/P-loop; other site 768492007392 ATP binding site [chemical binding]; other site 768492007393 Q-loop/lid; other site 768492007394 ABC transporter signature motif; other site 768492007395 Walker B; other site 768492007396 D-loop; other site 768492007397 H-loop/switch region; other site 768492007398 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768492007399 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 768492007400 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768492007401 Walker A/P-loop; other site 768492007402 ATP binding site [chemical binding]; other site 768492007403 Q-loop/lid; other site 768492007404 ABC transporter signature motif; other site 768492007405 Walker B; other site 768492007406 D-loop; other site 768492007407 H-loop/switch region; other site 768492007408 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 768492007409 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 768492007410 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 768492007411 active site 768492007412 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 768492007413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007414 putative substrate translocation pore; other site 768492007415 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492007416 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492007417 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492007418 dimerization interface [polypeptide binding]; other site 768492007419 penicillin-binding protein 2; Provisional; Region: PRK10795 768492007420 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 768492007421 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 768492007422 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 768492007423 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 768492007424 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 768492007425 lipoprotein; Provisional; Region: PRK10540 768492007426 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768492007427 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492007428 Coenzyme A binding pocket [chemical binding]; other site 768492007429 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 768492007430 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 768492007431 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 768492007432 Walker A/P-loop; other site 768492007433 ATP binding site [chemical binding]; other site 768492007434 Q-loop/lid; other site 768492007435 ABC transporter signature motif; other site 768492007436 Walker B; other site 768492007437 D-loop; other site 768492007438 H-loop/switch region; other site 768492007439 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768492007440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492007441 dimer interface [polypeptide binding]; other site 768492007442 conserved gate region; other site 768492007443 putative PBP binding loops; other site 768492007444 ABC-ATPase subunit interface; other site 768492007445 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492007446 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768492007447 substrate binding pocket [chemical binding]; other site 768492007448 membrane-bound complex binding site; other site 768492007449 hinge residues; other site 768492007450 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 768492007451 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 768492007452 active site 768492007453 non-prolyl cis peptide bond; other site 768492007454 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 768492007455 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492007456 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492007457 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 768492007458 putative effector binding pocket; other site 768492007459 putative dimerization interface [polypeptide binding]; other site 768492007460 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 768492007461 Beta-lactamase; Region: Beta-lactamase; pfam00144 768492007462 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768492007463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007464 putative substrate translocation pore; other site 768492007465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007466 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007467 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 768492007468 RibD C-terminal domain; Region: RibD_C; cl17279 768492007469 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 768492007470 Uncharacterized conserved protein [Function unknown]; Region: COG5276 768492007471 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 768492007472 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 768492007473 putative ligand binding site [chemical binding]; other site 768492007474 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 768492007475 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 768492007476 putative active site [active] 768492007477 metal binding site [ion binding]; metal-binding site 768492007478 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 768492007479 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 768492007480 putative NADP binding site [chemical binding]; other site 768492007481 putative substrate binding site [chemical binding]; other site 768492007482 active site 768492007483 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492007484 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768492007485 Pirin; Region: Pirin; pfam02678 768492007486 Pirin-related protein [General function prediction only]; Region: COG1741 768492007487 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 768492007488 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768492007489 Predicted transcriptional regulators [Transcription]; Region: COG1733 768492007490 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 768492007491 NmrA-like family; Region: NmrA; pfam05368 768492007492 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 768492007493 NADP binding site [chemical binding]; other site 768492007494 active site 768492007495 regulatory binding site [polypeptide binding]; other site 768492007496 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 768492007497 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 768492007498 putative NAD(P) binding site [chemical binding]; other site 768492007499 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492007500 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492007501 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492007502 putative effector binding pocket; other site 768492007503 dimerization interface [polypeptide binding]; other site 768492007504 Protein of unknown function (DUF419); Region: DUF419; cl15265 768492007505 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 768492007506 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 768492007507 Walker A/P-loop; other site 768492007508 ATP binding site [chemical binding]; other site 768492007509 Q-loop/lid; other site 768492007510 ABC transporter signature motif; other site 768492007511 Walker B; other site 768492007512 D-loop; other site 768492007513 H-loop/switch region; other site 768492007514 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 768492007515 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 768492007516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492007517 dimer interface [polypeptide binding]; other site 768492007518 conserved gate region; other site 768492007519 ABC-ATPase subunit interface; other site 768492007520 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 768492007521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492007522 dimer interface [polypeptide binding]; other site 768492007523 conserved gate region; other site 768492007524 putative PBP binding loops; other site 768492007525 ABC-ATPase subunit interface; other site 768492007526 Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867 768492007527 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 768492007528 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 768492007529 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 768492007530 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 768492007531 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768492007532 active site turn [active] 768492007533 phosphorylation site [posttranslational modification] 768492007534 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 768492007535 trimer interface; other site 768492007536 sugar binding site [chemical binding]; other site 768492007537 lac repressor; Reviewed; Region: lacI; PRK09526 768492007538 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492007539 DNA binding site [nucleotide binding] 768492007540 domain linker motif; other site 768492007541 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 768492007542 ligand binding site [chemical binding]; other site 768492007543 dimerization interface (open form) [polypeptide binding]; other site 768492007544 dimerization interface (closed form) [polypeptide binding]; other site 768492007545 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492007546 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768492007547 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768492007548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007549 putative substrate translocation pore; other site 768492007550 Alcaligenes xylosoxidans NreA and related domains; this domain family was previously known as part of DUF156; Region: NreA-like_DUF156; cd10154 768492007551 putative homodimer interface [polypeptide binding]; other site 768492007552 putative homotetramer interface [polypeptide binding]; other site 768492007553 putative metal binding site [ion binding]; other site 768492007554 putative homodimer-homodimer interface [polypeptide binding]; other site 768492007555 putative allosteric switch controlling residues; other site 768492007556 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 768492007557 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 768492007558 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 768492007559 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492007560 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 768492007561 hypothetical protein; Provisional; Region: PRK05208 768492007562 Rdx family; Region: Rdx; cl01407 768492007563 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 768492007564 Bacterial transcriptional regulator; Region: IclR; pfam01614 768492007565 PAS domain; Region: PAS; smart00091 768492007566 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492007567 Walker A motif; other site 768492007568 ATP binding site [chemical binding]; other site 768492007569 Walker B motif; other site 768492007570 arginine finger; other site 768492007571 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768492007572 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768492007573 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768492007574 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 768492007575 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 768492007576 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 768492007577 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 768492007578 putative ligand binding site [chemical binding]; other site 768492007579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007580 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768492007581 transcriptional regulator, ArgP family; Region: argP; TIGR03298 768492007582 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492007583 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492007584 putative effector binding pocket; other site 768492007585 dimerization interface [polypeptide binding]; other site 768492007586 Amidinotransferase; Region: Amidinotransf; cl12043 768492007587 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 768492007588 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492007589 substrate binding pocket [chemical binding]; other site 768492007590 membrane-bound complex binding site; other site 768492007591 hinge residues; other site 768492007592 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768492007593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492007594 dimer interface [polypeptide binding]; other site 768492007595 conserved gate region; other site 768492007596 putative PBP binding loops; other site 768492007597 ABC-ATPase subunit interface; other site 768492007598 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768492007599 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492007600 dimer interface [polypeptide binding]; other site 768492007601 conserved gate region; other site 768492007602 putative PBP binding loops; other site 768492007603 ABC-ATPase subunit interface; other site 768492007604 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768492007605 dimerization interface [polypeptide binding]; other site 768492007606 putative DNA binding site [nucleotide binding]; other site 768492007607 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 768492007608 putative Zn2+ binding site [ion binding]; other site 768492007609 AsnC family; Region: AsnC_trans_reg; pfam01037 768492007610 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 768492007611 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 768492007612 active site 768492007613 Zn binding site [ion binding]; other site 768492007614 Fic/DOC family; Region: Fic; pfam02661 768492007615 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 768492007616 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768492007617 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768492007618 Walker A/P-loop; other site 768492007619 ATP binding site [chemical binding]; other site 768492007620 Q-loop/lid; other site 768492007621 ABC transporter signature motif; other site 768492007622 Walker B; other site 768492007623 D-loop; other site 768492007624 H-loop/switch region; other site 768492007625 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 768492007626 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 768492007627 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 768492007628 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 768492007629 NAD binding site [chemical binding]; other site 768492007630 substrate binding site [chemical binding]; other site 768492007631 catalytic Zn binding site [ion binding]; other site 768492007632 tetramer interface [polypeptide binding]; other site 768492007633 structural Zn binding site [ion binding]; other site 768492007634 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Region: ALDH_ACDHII_AcoD-like; cd07559 768492007635 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 768492007636 NAD(P) binding site [chemical binding]; other site 768492007637 catalytic residues [active] 768492007638 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 768492007639 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492007640 Walker A motif; other site 768492007641 ATP binding site [chemical binding]; other site 768492007642 Walker B motif; other site 768492007643 arginine finger; other site 768492007644 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768492007645 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492007646 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768492007647 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 768492007648 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 768492007649 NAD(P) binding site [chemical binding]; other site 768492007650 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492007651 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768492007652 substrate binding pocket [chemical binding]; other site 768492007653 membrane-bound complex binding site; other site 768492007654 hinge residues; other site 768492007655 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492007656 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492007657 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492007658 putative effector binding pocket; other site 768492007659 dimerization interface [polypeptide binding]; other site 768492007660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007661 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768492007662 putative substrate translocation pore; other site 768492007663 PAS fold; Region: PAS_4; pfam08448 768492007664 PAS fold; Region: PAS_4; pfam08448 768492007665 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 768492007666 putative active site [active] 768492007667 heme pocket [chemical binding]; other site 768492007668 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768492007669 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768492007670 metal binding site [ion binding]; metal-binding site 768492007671 active site 768492007672 I-site; other site 768492007673 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768492007674 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 768492007675 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 768492007676 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 768492007677 Trp docking motif [polypeptide binding]; other site 768492007678 putative active site [active] 768492007679 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 768492007680 TAP-like protein; Region: Abhydrolase_4; pfam08386 768492007681 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492007682 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 768492007683 putative substrate binding pocket [chemical binding]; other site 768492007684 putative dimerization interface [polypeptide binding]; other site 768492007685 C factor cell-cell signaling protein; Provisional; Region: PRK09009 768492007686 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 768492007687 NADP binding site [chemical binding]; other site 768492007688 homodimer interface [polypeptide binding]; other site 768492007689 active site 768492007690 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 768492007691 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492007692 catalytic residue [active] 768492007693 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 768492007694 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768492007695 inhibitor-cofactor binding pocket; inhibition site 768492007696 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492007697 catalytic residue [active] 768492007698 Fucose-binding lectin II (PA-IIL); Region: PA-IIL; pfam07472 768492007699 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 768492007700 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 768492007701 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 768492007702 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 768492007703 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 768492007704 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768492007705 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768492007706 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768492007707 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768492007708 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768492007709 Surface antigen; Region: Bac_surface_Ag; pfam01103 768492007710 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 768492007711 active site 768492007712 catalytic residues [active] 768492007713 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768492007714 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492007715 DNA binding site [nucleotide binding] 768492007716 domain linker motif; other site 768492007717 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 768492007718 ligand binding site [chemical binding]; other site 768492007719 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 768492007720 active site 768492007721 P-loop; other site 768492007722 phosphorylation site [posttranslational modification] 768492007723 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 768492007724 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 768492007725 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 768492007726 beta-galactosidase; Region: BGL; TIGR03356 768492007727 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 768492007728 methionine cluster; other site 768492007729 active site 768492007730 phosphorylation site [posttranslational modification] 768492007731 metal binding site [ion binding]; metal-binding site 768492007732 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 768492007733 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492007734 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768492007735 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 768492007736 ABC transporter transmembrane region; Region: ABC_membrane_3; pfam13748 768492007737 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 768492007738 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768492007739 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 768492007740 E3 interaction surface; other site 768492007741 lipoyl attachment site [posttranslational modification]; other site 768492007742 e3 binding domain; Region: E3_binding; pfam02817 768492007743 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 768492007744 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 768492007745 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 768492007746 dimer interface [polypeptide binding]; other site 768492007747 TPP-binding site [chemical binding]; other site 768492007748 MarR family; Region: MarR; pfam01047 768492007749 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768492007750 FAD dependent oxidoreductase; Region: DAO; pfam01266 768492007751 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 768492007752 Predicted transcriptional regulators [Transcription]; Region: COG1733 768492007753 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 768492007754 short chain dehydrogenase; Provisional; Region: PRK06179 768492007755 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 768492007756 NADP binding site [chemical binding]; other site 768492007757 active site 768492007758 steroid binding site; other site 768492007759 YCII-related domain; Region: YCII; cl00999 768492007760 Predicted transcriptional regulators [Transcription]; Region: COG1733 768492007761 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 768492007762 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 768492007763 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 768492007764 NADP binding site [chemical binding]; other site 768492007765 MarR family; Region: MarR_2; cl17246 768492007766 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768492007767 EamA-like transporter family; Region: EamA; pfam00892 768492007768 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 768492007769 EamA-like transporter family; Region: EamA; pfam00892 768492007770 Nitroreductase [Energy production and conversion]; Region: NfnB; COG0778 768492007771 FMN binding site [chemical binding]; other site 768492007772 Winged helix-turn helix; Region: HTH_29; pfam13551 768492007773 Helix-turn-helix domain; Region: HTH_28; pfam13518 768492007774 Homeodomain-like domain; Region: HTH_32; pfam13565 768492007775 Integrase core domain; Region: rve; pfam00665 768492007776 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768492007777 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 768492007778 catalytic site [active] 768492007779 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 768492007780 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492007781 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 768492007782 dimerization interface [polypeptide binding]; other site 768492007783 substrate binding pocket [chemical binding]; other site 768492007784 SnoaL-like domain; Region: SnoaL_4; pfam13577 768492007785 Amidohydrolase; Region: Amidohydro_2; pfam04909 768492007786 Methyltransferase domain; Region: Methyltransf_23; pfam13489 768492007787 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 768492007788 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492007789 S-adenosylmethionine binding site [chemical binding]; other site 768492007790 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 768492007791 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 768492007792 putative ligand binding site [chemical binding]; other site 768492007793 NAD binding site [chemical binding]; other site 768492007794 catalytic site [active] 768492007795 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492007796 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492007797 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 768492007798 putative substrate binding pocket [chemical binding]; other site 768492007799 putative dimerization interface [polypeptide binding]; other site 768492007800 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 768492007801 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 768492007802 Predicted transcriptional regulators [Transcription]; Region: COG1733 768492007803 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 768492007804 Transcriptional regulators [Transcription]; Region: MarR; COG1846 768492007805 MarR family; Region: MarR_2; pfam12802 768492007806 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492007807 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768492007808 Coenzyme A binding pocket [chemical binding]; other site 768492007809 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 768492007810 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007811 putative substrate translocation pore; other site 768492007812 Uncharacterized conserved protein [Function unknown]; Region: COG4925 768492007813 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 768492007814 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 768492007815 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492007816 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492007817 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 768492007818 putative effector binding pocket; other site 768492007819 putative dimerization interface [polypeptide binding]; other site 768492007820 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492007821 transcriptional activator TtdR; Provisional; Region: PRK09801 768492007822 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492007823 dimerization interface [polypeptide binding]; other site 768492007824 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 768492007825 active site 768492007826 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 768492007827 YheO-like PAS domain; Region: PAS_6; pfam08348 768492007828 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 768492007829 HTH domain; Region: HTH_22; pfam13309 768492007830 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 768492007831 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 768492007832 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 768492007833 NAD(P) binding site [chemical binding]; other site 768492007834 intracellular protease, PfpI family; Region: PfpI; TIGR01382 768492007835 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 768492007836 conserved cys residue [active] 768492007837 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 768492007838 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 768492007839 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 768492007840 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 768492007841 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768492007842 HlyD family secretion protein; Region: HlyD_3; pfam13437 768492007843 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 768492007844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007845 putative substrate translocation pore; other site 768492007846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007847 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492007848 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768492007849 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 768492007850 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 768492007851 active site 768492007852 homotetramer interface [polypeptide binding]; other site 768492007853 homodimer interface [polypeptide binding]; other site 768492007854 benzoate transporter; Region: benE; TIGR00843 768492007855 Benzoate membrane transport protein; Region: BenE; pfam03594 768492007856 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768492007857 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492007858 DNA-binding site [nucleotide binding]; DNA binding site 768492007859 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492007860 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492007861 homodimer interface [polypeptide binding]; other site 768492007862 catalytic residue [active] 768492007863 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768492007864 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492007865 non-specific DNA binding site [nucleotide binding]; other site 768492007866 salt bridge; other site 768492007867 sequence-specific DNA binding site [nucleotide binding]; other site 768492007868 Cupin domain; Region: Cupin_2; cl17218 768492007869 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768492007870 EamA-like transporter family; Region: EamA; pfam00892 768492007871 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492007872 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492007873 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768492007874 dimerization interface [polypeptide binding]; other site 768492007875 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 768492007876 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 768492007877 active site 768492007878 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 768492007879 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 768492007880 Flavin binding site [chemical binding]; other site 768492007881 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 768492007882 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 768492007883 active site 768492007884 non-prolyl cis peptide bond; other site 768492007885 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 768492007886 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 768492007887 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 768492007888 Walker A/P-loop; other site 768492007889 ATP binding site [chemical binding]; other site 768492007890 Q-loop/lid; other site 768492007891 ABC transporter signature motif; other site 768492007892 Walker B; other site 768492007893 D-loop; other site 768492007894 H-loop/switch region; other site 768492007895 NIL domain; Region: NIL; cl09633 768492007896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492007897 dimer interface [polypeptide binding]; other site 768492007898 conserved gate region; other site 768492007899 ABC-ATPase subunit interface; other site 768492007900 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 768492007901 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492007902 substrate binding pocket [chemical binding]; other site 768492007903 membrane-bound complex binding site; other site 768492007904 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 768492007905 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 768492007906 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492007907 catalytic residue [active] 768492007908 serine O-acetyltransferase; Region: cysE; TIGR01172 768492007909 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 768492007910 trimer interface [polypeptide binding]; other site 768492007911 active site 768492007912 substrate binding site [chemical binding]; other site 768492007913 CoA binding site [chemical binding]; other site 768492007914 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 768492007915 active site residue [active] 768492007916 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 768492007917 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 768492007918 putative ligand binding site [chemical binding]; other site 768492007919 NAD binding site [chemical binding]; other site 768492007920 catalytic site [active] 768492007921 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007922 D-galactonate transporter; Region: 2A0114; TIGR00893 768492007923 putative substrate translocation pore; other site 768492007924 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007925 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 768492007926 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768492007927 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768492007928 putative active site [active] 768492007929 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 768492007930 beta-galactosidase; Region: BGL; TIGR03356 768492007931 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 768492007932 heterodimer interface [polypeptide binding]; other site 768492007933 multimer interface [polypeptide binding]; other site 768492007934 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 768492007935 active site 768492007936 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 768492007937 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 768492007938 heterodimer interface [polypeptide binding]; other site 768492007939 active site 768492007940 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 768492007941 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492007942 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492007943 dimerization interface [polypeptide binding]; other site 768492007944 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 768492007945 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 768492007946 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 768492007947 tetramer interface [polypeptide binding]; other site 768492007948 active site 768492007949 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 768492007950 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768492007951 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 768492007952 benzoate transport; Region: 2A0115; TIGR00895 768492007953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007954 putative substrate translocation pore; other site 768492007955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007956 benzoate transport; Region: 2A0115; TIGR00895 768492007957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007958 putative substrate translocation pore; other site 768492007959 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492007960 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 768492007961 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 768492007962 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 768492007963 shikimate binding site; other site 768492007964 NAD(P) binding site [chemical binding]; other site 768492007965 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 768492007966 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 768492007967 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 768492007968 dimer interface [polypeptide binding]; other site 768492007969 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 768492007970 active site 768492007971 Fe binding site [ion binding]; other site 768492007972 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 768492007973 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 768492007974 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768492007975 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 768492007976 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768492007977 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 768492007978 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 768492007979 Bacterial transcriptional regulator; Region: IclR; pfam01614 768492007980 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 768492007981 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 768492007982 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492007983 catalytic residue [active] 768492007984 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 768492007985 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 768492007986 dimer interface [polypeptide binding]; other site 768492007987 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 768492007988 MASE1; Region: MASE1; cl17823 768492007989 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768492007990 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768492007991 metal binding site [ion binding]; metal-binding site 768492007992 active site 768492007993 I-site; other site 768492007994 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768492007995 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492007996 Coenzyme A binding pocket [chemical binding]; other site 768492007997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492007998 dimer interface [polypeptide binding]; other site 768492007999 conserved gate region; other site 768492008000 ABC-ATPase subunit interface; other site 768492008001 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 768492008002 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 768492008003 Walker A/P-loop; other site 768492008004 ATP binding site [chemical binding]; other site 768492008005 Q-loop/lid; other site 768492008006 ABC transporter signature motif; other site 768492008007 Walker B; other site 768492008008 D-loop; other site 768492008009 H-loop/switch region; other site 768492008010 NIL domain; Region: NIL; pfam09383 768492008011 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 768492008012 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 768492008013 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 768492008014 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 768492008015 putative N- and C-terminal domain interface [polypeptide binding]; other site 768492008016 putative active site [active] 768492008017 MgATP binding site [chemical binding]; other site 768492008018 catalytic site [active] 768492008019 metal binding site [ion binding]; metal-binding site 768492008020 putative xylulose binding site [chemical binding]; other site 768492008021 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 768492008022 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 768492008023 putative ligand binding site [chemical binding]; other site 768492008024 putative NAD binding site [chemical binding]; other site 768492008025 catalytic site [active] 768492008026 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 768492008027 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768492008028 substrate binding site [chemical binding]; other site 768492008029 ATP binding site [chemical binding]; other site 768492008030 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768492008031 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768492008032 TM-ABC transporter signature motif; other site 768492008033 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768492008034 TM-ABC transporter signature motif; other site 768492008035 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 768492008036 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768492008037 Walker A/P-loop; other site 768492008038 ATP binding site [chemical binding]; other site 768492008039 Q-loop/lid; other site 768492008040 ABC transporter signature motif; other site 768492008041 Walker B; other site 768492008042 D-loop; other site 768492008043 H-loop/switch region; other site 768492008044 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768492008045 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 768492008046 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 768492008047 putative ligand binding site [chemical binding]; other site 768492008048 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 768492008049 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 768492008050 Ca binding site [ion binding]; other site 768492008051 active site 768492008052 catalytic site [active] 768492008053 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 768492008054 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 768492008055 Walker A/P-loop; other site 768492008056 ATP binding site [chemical binding]; other site 768492008057 Q-loop/lid; other site 768492008058 ABC transporter signature motif; other site 768492008059 Walker B; other site 768492008060 D-loop; other site 768492008061 H-loop/switch region; other site 768492008062 TOBE domain; Region: TOBE_2; pfam08402 768492008063 alpha-galactosidase; Provisional; Region: PRK15076 768492008064 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 768492008065 NAD(P) binding site [chemical binding]; other site 768492008066 LDH/MDH dimer interface [polypeptide binding]; other site 768492008067 substrate binding site [chemical binding]; other site 768492008068 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 768492008069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492008070 dimer interface [polypeptide binding]; other site 768492008071 conserved gate region; other site 768492008072 putative PBP binding loops; other site 768492008073 ABC-ATPase subunit interface; other site 768492008074 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492008075 dimer interface [polypeptide binding]; other site 768492008076 conserved gate region; other site 768492008077 putative PBP binding loops; other site 768492008078 ABC-ATPase subunit interface; other site 768492008079 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 768492008080 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 768492008081 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492008082 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492008083 LysR substrate binding domain; Region: LysR_substrate; pfam03466 768492008084 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768492008085 active site turn [active] 768492008086 phosphorylation site [posttranslational modification] 768492008087 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 768492008088 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 768492008089 Mechanosensitive ion channel; Region: MS_channel; pfam00924 768492008090 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 768492008091 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768492008092 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768492008093 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 768492008094 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768492008095 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768492008096 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492008097 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 768492008098 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 768492008099 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 768492008100 active site 768492008101 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 768492008102 Cation efflux family; Region: Cation_efflux; cl00316 768492008103 Cation efflux family; Region: Cation_efflux; cl00316 768492008104 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 768492008105 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 768492008106 Divalent cation transporter; Region: MgtE; pfam01769 768492008107 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 768492008108 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 768492008109 peptide binding site [polypeptide binding]; other site 768492008110 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768492008111 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 768492008112 active site 768492008113 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768492008114 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492008115 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492008116 dimerization interface [polypeptide binding]; other site 768492008117 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 768492008118 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 768492008119 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 768492008120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492008121 dimer interface [polypeptide binding]; other site 768492008122 conserved gate region; other site 768492008123 putative PBP binding loops; other site 768492008124 ABC-ATPase subunit interface; other site 768492008125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492008126 dimer interface [polypeptide binding]; other site 768492008127 conserved gate region; other site 768492008128 putative PBP binding loops; other site 768492008129 ABC-ATPase subunit interface; other site 768492008130 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 768492008131 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 768492008132 Walker A/P-loop; other site 768492008133 ATP binding site [chemical binding]; other site 768492008134 Q-loop/lid; other site 768492008135 ABC transporter signature motif; other site 768492008136 Walker B; other site 768492008137 D-loop; other site 768492008138 H-loop/switch region; other site 768492008139 elongation factor G; Reviewed; Region: PRK00007 768492008140 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 768492008141 G1 box; other site 768492008142 putative GEF interaction site [polypeptide binding]; other site 768492008143 GTP/Mg2+ binding site [chemical binding]; other site 768492008144 Switch I region; other site 768492008145 G2 box; other site 768492008146 G3 box; other site 768492008147 Switch II region; other site 768492008148 G4 box; other site 768492008149 G5 box; other site 768492008150 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 768492008151 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 768492008152 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 768492008153 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768492008154 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 768492008155 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 768492008156 GIY-YIG motif/motif A; other site 768492008157 MarR family; Region: MarR_2; cl17246 768492008158 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768492008159 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492008160 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768492008161 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 768492008162 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 768492008163 tetramerization interface [polypeptide binding]; other site 768492008164 NAD(P) binding site [chemical binding]; other site 768492008165 catalytic residues [active] 768492008166 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 768492008167 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 768492008168 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 768492008169 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 768492008170 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492008171 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768492008172 Cupin domain; Region: Cupin_2; pfam07883 768492008173 K+ potassium transporter; Region: K_trans; pfam02705 768492008174 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768492008175 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492008176 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 768492008177 dimerization interface [polypeptide binding]; other site 768492008178 substrate binding pocket [chemical binding]; other site 768492008179 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768492008180 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 768492008181 TM-ABC transporter signature motif; other site 768492008182 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 768492008183 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768492008184 TM-ABC transporter signature motif; other site 768492008185 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 768492008186 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 768492008187 Walker A/P-loop; other site 768492008188 ATP binding site [chemical binding]; other site 768492008189 Q-loop/lid; other site 768492008190 ABC transporter signature motif; other site 768492008191 Walker B; other site 768492008192 D-loop; other site 768492008193 H-loop/switch region; other site 768492008194 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 768492008195 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 768492008196 Walker A/P-loop; other site 768492008197 ATP binding site [chemical binding]; other site 768492008198 Q-loop/lid; other site 768492008199 ABC transporter signature motif; other site 768492008200 Walker B; other site 768492008201 D-loop; other site 768492008202 H-loop/switch region; other site 768492008203 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 768492008204 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 768492008205 dimerization interface [polypeptide binding]; other site 768492008206 ligand binding site [chemical binding]; other site 768492008207 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 768492008208 allantoate amidohydrolase; Reviewed; Region: PRK09290 768492008209 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 768492008210 active site 768492008211 metal binding site [ion binding]; metal-binding site 768492008212 dimer interface [polypeptide binding]; other site 768492008213 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768492008214 dimerization interface [polypeptide binding]; other site 768492008215 putative DNA binding site [nucleotide binding]; other site 768492008216 putative Zn2+ binding site [ion binding]; other site 768492008217 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 768492008218 putative hydrophobic ligand binding site [chemical binding]; other site 768492008219 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 768492008220 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 768492008221 Cl binding site [ion binding]; other site 768492008222 oligomer interface [polypeptide binding]; other site 768492008223 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 768492008224 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 768492008225 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 768492008226 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 768492008227 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 768492008228 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 768492008229 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 768492008230 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 768492008231 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492008232 DNA-binding site [nucleotide binding]; DNA binding site 768492008233 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768492008234 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492008235 catalytic residue [active] 768492008236 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 768492008237 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 768492008238 catalytic triad [active] 768492008239 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 768492008240 dimer interface [polypeptide binding]; other site 768492008241 pyridoxamine kinase; Validated; Region: PRK05756 768492008242 pyridoxal binding site [chemical binding]; other site 768492008243 ATP binding site [chemical binding]; other site 768492008244 Flagellar regulator YcgR; Region: YcgR; pfam07317 768492008245 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 768492008246 PilZ domain; Region: PilZ; pfam07238 768492008247 N-formylglutamate amidohydrolase; Region: FGase; cl01522 768492008248 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 768492008249 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 768492008250 putative acyl-acceptor binding pocket; other site 768492008251 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 768492008252 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 768492008253 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 768492008254 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 768492008255 DNA binding site [nucleotide binding] 768492008256 active site 768492008257 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 768492008258 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 768492008259 ligand binding site [chemical binding]; other site 768492008260 flexible hinge region; other site 768492008261 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 768492008262 putative switch regulator; other site 768492008263 non-specific DNA interactions [nucleotide binding]; other site 768492008264 DNA binding site [nucleotide binding] 768492008265 sequence specific DNA binding site [nucleotide binding]; other site 768492008266 putative cAMP binding site [chemical binding]; other site 768492008267 universal stress protein UspE; Provisional; Region: PRK11175 768492008268 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 768492008269 Ligand Binding Site [chemical binding]; other site 768492008270 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 768492008271 Ligand Binding Site [chemical binding]; other site 768492008272 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 768492008273 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 768492008274 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 768492008275 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 768492008276 ligand binding site [chemical binding]; other site 768492008277 homodimer interface [polypeptide binding]; other site 768492008278 NAD(P) binding site [chemical binding]; other site 768492008279 trimer interface B [polypeptide binding]; other site 768492008280 trimer interface A [polypeptide binding]; other site 768492008281 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 768492008282 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 768492008283 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 768492008284 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 768492008285 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 768492008286 dihydromonapterin reductase; Provisional; Region: PRK06483 768492008287 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492008288 NAD(P) binding site [chemical binding]; other site 768492008289 active site 768492008290 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 768492008291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492008292 active site 768492008293 phosphorylation site [posttranslational modification] 768492008294 intermolecular recognition site; other site 768492008295 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768492008296 DNA binding site [nucleotide binding] 768492008297 sensor protein RstB; Provisional; Region: PRK10604 768492008298 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768492008299 dimerization interface [polypeptide binding]; other site 768492008300 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492008301 dimer interface [polypeptide binding]; other site 768492008302 phosphorylation site [posttranslational modification] 768492008303 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492008304 ATP binding site [chemical binding]; other site 768492008305 Mg2+ binding site [ion binding]; other site 768492008306 G-X-G motif; other site 768492008307 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 768492008308 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 768492008309 active site 768492008310 Zn binding site [ion binding]; other site 768492008311 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 768492008312 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 768492008313 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 768492008314 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 768492008315 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768492008316 ATP binding site [chemical binding]; other site 768492008317 putative Mg++ binding site [ion binding]; other site 768492008318 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768492008319 nucleotide binding region [chemical binding]; other site 768492008320 ATP-binding site [chemical binding]; other site 768492008321 Helicase associated domain (HA2); Region: HA2; pfam04408 768492008322 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 768492008323 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 768492008324 azoreductase; Reviewed; Region: PRK00170 768492008325 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768492008326 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 768492008327 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 768492008328 hypothetical protein; Provisional; Region: PRK10695 768492008329 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 768492008330 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 768492008331 putative ligand binding site [chemical binding]; other site 768492008332 putative NAD binding site [chemical binding]; other site 768492008333 catalytic site [active] 768492008334 heat-inducible protein; Provisional; Region: PRK10449 768492008335 Domain of unknown function (DUF333); Region: DUF333; pfam03891 768492008336 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 768492008337 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 768492008338 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 768492008339 dimer interface [polypeptide binding]; other site 768492008340 PYR/PP interface [polypeptide binding]; other site 768492008341 TPP binding site [chemical binding]; other site 768492008342 substrate binding site [chemical binding]; other site 768492008343 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 768492008344 Domain of unknown function; Region: EKR; pfam10371 768492008345 4Fe-4S binding domain; Region: Fer4_6; pfam12837 768492008346 4Fe-4S binding domain; Region: Fer4; pfam00037 768492008347 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 768492008348 TPP-binding site [chemical binding]; other site 768492008349 dimer interface [polypeptide binding]; other site 768492008350 Alginate lyase; Region: Alginate_lyase; pfam05426 768492008351 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768492008352 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492008353 non-specific DNA binding site [nucleotide binding]; other site 768492008354 salt bridge; other site 768492008355 sequence-specific DNA binding site [nucleotide binding]; other site 768492008356 Cupin domain; Region: Cupin_2; cl17218 768492008357 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 768492008358 B3/4 domain; Region: B3_4; pfam03483 768492008359 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 768492008360 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 768492008361 Ligand Binding Site [chemical binding]; other site 768492008362 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 768492008363 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768492008364 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 768492008365 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 768492008366 Cl binding site [ion binding]; other site 768492008367 oligomer interface [polypeptide binding]; other site 768492008368 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 768492008369 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 768492008370 peptide binding site [polypeptide binding]; other site 768492008371 Flagellar regulator YcgR; Region: YcgR; pfam07317 768492008372 murein peptide amidase A; Provisional; Region: PRK10602 768492008373 active site 768492008374 Zn binding site [ion binding]; other site 768492008375 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 768492008376 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 768492008377 active site 768492008378 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 768492008379 dimer interface [polypeptide binding]; other site 768492008380 catalytic triad [active] 768492008381 peroxidatic and resolving cysteines [active] 768492008382 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 768492008383 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 768492008384 putative aromatic amino acid binding site; other site 768492008385 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768492008386 putative active site [active] 768492008387 heme pocket [chemical binding]; other site 768492008388 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492008389 Walker A motif; other site 768492008390 ATP binding site [chemical binding]; other site 768492008391 Walker B motif; other site 768492008392 arginine finger; other site 768492008393 hypothetical protein; Provisional; Region: PRK05415 768492008394 Domain of unknown function (DUF697); Region: DUF697; cl12064 768492008395 Predicted ATPase [General function prediction only]; Region: COG3106 768492008396 Phage shock protein PspD (Phageshock_PspD); Region: Phageshock_PspD; pfam09584 768492008397 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 768492008398 phage shock protein C; Region: phageshock_pspC; TIGR02978 768492008399 phage shock protein B; Provisional; Region: pspB; PRK09458 768492008400 phage shock protein PspA; Provisional; Region: PRK10698 768492008401 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 768492008402 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492008403 Walker A motif; other site 768492008404 ATP binding site [chemical binding]; other site 768492008405 Walker B motif; other site 768492008406 arginine finger; other site 768492008407 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768492008408 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 768492008409 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 768492008410 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 768492008411 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 768492008412 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 768492008413 trimer interface [polypeptide binding]; other site 768492008414 active site 768492008415 putative GTP cyclohydrolase; Provisional; Region: PRK13674 768492008416 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 768492008417 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 768492008418 peptide binding site [polypeptide binding]; other site 768492008419 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 768492008420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492008421 dimer interface [polypeptide binding]; other site 768492008422 conserved gate region; other site 768492008423 putative PBP binding loops; other site 768492008424 ABC-ATPase subunit interface; other site 768492008425 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 768492008426 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 768492008427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492008428 dimer interface [polypeptide binding]; other site 768492008429 conserved gate region; other site 768492008430 putative PBP binding loops; other site 768492008431 ABC-ATPase subunit interface; other site 768492008432 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 768492008433 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768492008434 Walker A/P-loop; other site 768492008435 ATP binding site [chemical binding]; other site 768492008436 Q-loop/lid; other site 768492008437 ABC transporter signature motif; other site 768492008438 Walker B; other site 768492008439 D-loop; other site 768492008440 H-loop/switch region; other site 768492008441 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 768492008442 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 768492008443 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768492008444 Walker A/P-loop; other site 768492008445 ATP binding site [chemical binding]; other site 768492008446 Q-loop/lid; other site 768492008447 ABC transporter signature motif; other site 768492008448 Walker B; other site 768492008449 D-loop; other site 768492008450 H-loop/switch region; other site 768492008451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 768492008452 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 768492008453 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 768492008454 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492008455 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492008456 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768492008457 dimerization interface [polypeptide binding]; other site 768492008458 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 768492008459 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 768492008460 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 768492008461 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 768492008462 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 768492008463 putative molybdopterin cofactor binding site [chemical binding]; other site 768492008464 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 768492008465 putative molybdopterin cofactor binding site; other site 768492008466 exoribonuclease II; Provisional; Region: PRK05054 768492008467 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 768492008468 RNB domain; Region: RNB; pfam00773 768492008469 S1 RNA binding domain; Region: S1; pfam00575 768492008470 carbon starvation protein A; Provisional; Region: PRK15015 768492008471 Carbon starvation protein CstA; Region: CstA; pfam02554 768492008472 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 768492008473 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 768492008474 active site 768492008475 intersubunit interactions; other site 768492008476 catalytic residue [active] 768492008477 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 768492008478 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 768492008479 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 768492008480 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 768492008481 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 768492008482 intersubunit interface [polypeptide binding]; other site 768492008483 active site 768492008484 Zn2+ binding site [ion binding]; other site 768492008485 lipoprotein; Provisional; Region: PRK10540 768492008486 translation initiation factor Sui1; Validated; Region: PRK06824 768492008487 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 768492008488 putative rRNA binding site [nucleotide binding]; other site 768492008489 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 768492008490 active site 768492008491 dimer interface [polypeptide binding]; other site 768492008492 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 768492008493 tetratricopeptide repeat protein; Provisional; Region: PRK11788 768492008494 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 768492008495 TPR motif; other site 768492008496 binding surface 768492008497 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 768492008498 binding surface 768492008499 TPR motif; other site 768492008500 Predicted membrane protein [Function unknown]; Region: COG3771 768492008501 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 768492008502 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 768492008503 active site 768492008504 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 768492008505 dimerization interface [polypeptide binding]; other site 768492008506 active site 768492008507 aconitate hydratase; Validated; Region: PRK09277 768492008508 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 768492008509 substrate binding site [chemical binding]; other site 768492008510 ligand binding site [chemical binding]; other site 768492008511 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 768492008512 substrate binding site [chemical binding]; other site 768492008513 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 768492008514 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492008515 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 768492008516 substrate binding site [chemical binding]; other site 768492008517 putative dimerization interface [polypeptide binding]; other site 768492008518 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 768492008519 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 768492008520 active site 768492008521 interdomain interaction site; other site 768492008522 putative metal-binding site [ion binding]; other site 768492008523 nucleotide binding site [chemical binding]; other site 768492008524 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 768492008525 domain I; other site 768492008526 DNA binding groove [nucleotide binding] 768492008527 phosphate binding site [ion binding]; other site 768492008528 domain II; other site 768492008529 domain III; other site 768492008530 nucleotide binding site [chemical binding]; other site 768492008531 catalytic site [active] 768492008532 domain IV; other site 768492008533 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 768492008534 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 768492008535 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 768492008536 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 768492008537 hypothetical protein; Provisional; Region: PRK11037 768492008538 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 768492008539 putative inner membrane peptidase; Provisional; Region: PRK11778 768492008540 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 768492008541 tandem repeat interface [polypeptide binding]; other site 768492008542 oligomer interface [polypeptide binding]; other site 768492008543 active site residues [active] 768492008544 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 768492008545 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 768492008546 NADP binding site [chemical binding]; other site 768492008547 homodimer interface [polypeptide binding]; other site 768492008548 active site 768492008549 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 768492008550 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 768492008551 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 768492008552 homodimer interface [polypeptide binding]; other site 768492008553 Walker A motif; other site 768492008554 ATP binding site [chemical binding]; other site 768492008555 hydroxycobalamin binding site [chemical binding]; other site 768492008556 Walker B motif; other site 768492008557 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 768492008558 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768492008559 RNA binding surface [nucleotide binding]; other site 768492008560 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 768492008561 probable active site [active] 768492008562 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768492008563 hypothetical protein; Provisional; Region: PRK11630 768492008564 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 768492008565 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 768492008566 active site 768492008567 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 768492008568 anthranilate synthase component I; Provisional; Region: PRK13564 768492008569 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 768492008570 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 768492008571 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 768492008572 Glutamine amidotransferase class-I; Region: GATase; pfam00117 768492008573 glutamine binding [chemical binding]; other site 768492008574 catalytic triad [active] 768492008575 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 768492008576 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 768492008577 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 768492008578 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 768492008579 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 768492008580 active site 768492008581 ribulose/triose binding site [chemical binding]; other site 768492008582 phosphate binding site [ion binding]; other site 768492008583 substrate (anthranilate) binding pocket [chemical binding]; other site 768492008584 product (indole) binding pocket [chemical binding]; other site 768492008585 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 768492008586 active site 768492008587 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 768492008588 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 768492008589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492008590 catalytic residue [active] 768492008591 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 768492008592 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 768492008593 substrate binding site [chemical binding]; other site 768492008594 active site 768492008595 catalytic residues [active] 768492008596 heterodimer interface [polypeptide binding]; other site 768492008597 BON domain; Region: BON; pfam04972 768492008598 outer membrane protein W; Provisional; Region: PRK10959 768492008599 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 768492008600 hypothetical protein; Provisional; Region: PRK02868 768492008601 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 768492008602 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 768492008603 Sulfate transporter family; Region: Sulfate_transp; pfam00916 768492008604 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 768492008605 intracellular septation protein A; Reviewed; Region: PRK00259 768492008606 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 768492008607 transport protein TonB; Provisional; Region: PRK10819 768492008608 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 768492008609 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 768492008610 YciI-like protein; Reviewed; Region: PRK11370 768492008611 Head binding; Region: Head_binding; pfam09008 768492008612 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 768492008613 active site 768492008614 Mnt; Region: mnt; PHA01513 768492008615 Arc-like DNA binding domain; Region: Arc; pfam03869 768492008616 Regulatory protein Mnt; Region: Repressor_Mnt; pfam11423 768492008617 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 768492008618 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 768492008619 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768492008620 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768492008621 catalytic residue [active] 768492008622 Protein of unknown function (DUF2824); Region: DUF2824; cl10279 768492008623 Phage stabilisation protein; Region: Phage_stabilise; pfam11134 768492008624 P22 tail accessory factor; Region: P22_Tail-4; pfam11650 768492008625 coat protein; Region: PHA01511 768492008626 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 768492008627 Bacteriophage, scaffolding protein; Region: Phage-scaffold; pfam09306 768492008628 Terminase-like family; Region: Terminase_6; pfam03237 768492008629 Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565 768492008630 Terminase small subunit; Region: Terminase_2; pfam03592 768492008631 Protein of unknown function (DUF2560); Region: DUF2560; cl10280 768492008632 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 768492008633 Predicted chitinase [General function prediction only]; Region: COG3179 768492008634 catalytic residue [active] 768492008635 Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106 768492008636 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 768492008637 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 768492008638 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 768492008639 nucleotide binding site [chemical binding]; other site 768492008640 Virulence-associated protein E; Region: VirE; pfam05272 768492008641 putative Cro-like protein; Region: PHA00542 768492008642 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768492008643 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492008644 sequence-specific DNA binding site [nucleotide binding]; other site 768492008645 salt bridge; other site 768492008646 Predicted transcriptional regulator [Transcription]; Region: COG2932 768492008647 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 768492008648 Catalytic site [active] 768492008649 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 768492008650 hypothetical protein; Provisional; Region: PRK09946 768492008651 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 768492008652 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 768492008653 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 768492008654 active site 768492008655 substrate binding site [chemical binding]; other site 768492008656 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 768492008657 active site 768492008658 DNA binding site [nucleotide binding] 768492008659 catalytic site [active] 768492008660 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 768492008661 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 768492008662 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 768492008663 ATP binding site [chemical binding]; other site 768492008664 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768492008665 nucleotide binding region [chemical binding]; other site 768492008666 ATP-binding site [chemical binding]; other site 768492008667 integrase; Provisional; Region: PRK09692 768492008668 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 768492008669 active site 768492008670 Int/Topo IB signature motif; other site 768492008671 KTSC domain; Region: KTSC; pfam13619 768492008672 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492008673 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768492008674 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 768492008675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492008676 putative substrate translocation pore; other site 768492008677 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 768492008678 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 768492008679 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 768492008680 putative active site [active] 768492008681 catalytic site [active] 768492008682 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 768492008683 putative active site [active] 768492008684 catalytic site [active] 768492008685 dsDNA-mimic protein; Reviewed; Region: PRK05094 768492008686 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 768492008687 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768492008688 Walker A/P-loop; other site 768492008689 ATP binding site [chemical binding]; other site 768492008690 Q-loop/lid; other site 768492008691 ABC transporter signature motif; other site 768492008692 Walker B; other site 768492008693 D-loop; other site 768492008694 H-loop/switch region; other site 768492008695 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 768492008696 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 768492008697 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768492008698 Walker A/P-loop; other site 768492008699 ATP binding site [chemical binding]; other site 768492008700 Q-loop/lid; other site 768492008701 ABC transporter signature motif; other site 768492008702 Walker B; other site 768492008703 D-loop; other site 768492008704 H-loop/switch region; other site 768492008705 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768492008706 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 768492008707 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 768492008708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492008709 dimer interface [polypeptide binding]; other site 768492008710 conserved gate region; other site 768492008711 ABC-ATPase subunit interface; other site 768492008712 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 768492008713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492008714 dimer interface [polypeptide binding]; other site 768492008715 conserved gate region; other site 768492008716 putative PBP binding loops; other site 768492008717 ABC-ATPase subunit interface; other site 768492008718 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 768492008719 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 768492008720 peptide binding site [polypeptide binding]; other site 768492008721 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 768492008722 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 768492008723 peptide binding site [polypeptide binding]; other site 768492008724 hypothetical protein; Provisional; Region: PRK11111 768492008725 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 768492008726 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 768492008727 putative catalytic cysteine [active] 768492008728 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 768492008729 putative active site [active] 768492008730 metal binding site [ion binding]; metal-binding site 768492008731 thymidine kinase; Provisional; Region: PRK04296 768492008732 Uncharacterized conserved protein (DUF2217); Region: DUF2217; pfam10265 768492008733 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 768492008734 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 768492008735 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768492008736 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 768492008737 putative NAD(P) binding site [chemical binding]; other site 768492008738 active site 768492008739 putative substrate binding site [chemical binding]; other site 768492008740 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 768492008741 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 768492008742 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 768492008743 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 768492008744 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 768492008745 active site 768492008746 tetramer interface; other site 768492008747 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492008748 active site 768492008749 response regulator of RpoS; Provisional; Region: PRK10693 768492008750 phosphorylation site [posttranslational modification] 768492008751 intermolecular recognition site; other site 768492008752 dimerization interface [polypeptide binding]; other site 768492008753 hypothetical protein; Provisional; Region: PRK10279 768492008754 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 768492008755 nucleophile elbow; other site 768492008756 SEC-C motif; Region: SEC-C; pfam02810 768492008757 hypothetical protein; Provisional; Region: PRK04233 768492008758 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 768492008759 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 768492008760 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 768492008761 putative active site [active] 768492008762 putative substrate binding site [chemical binding]; other site 768492008763 putative cosubstrate binding site; other site 768492008764 catalytic site [active] 768492008765 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 768492008766 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 768492008767 putative catalytic site [active] 768492008768 putative phosphate binding site [ion binding]; other site 768492008769 active site 768492008770 metal binding site A [ion binding]; metal-binding site 768492008771 DNA binding site [nucleotide binding] 768492008772 putative AP binding site [nucleotide binding]; other site 768492008773 putative metal binding site B [ion binding]; other site 768492008774 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 768492008775 active site 768492008776 8-oxo-dGMP binding site [chemical binding]; other site 768492008777 nudix motif; other site 768492008778 metal binding site [ion binding]; metal-binding site 768492008779 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 768492008780 DNA topoisomerase III; Provisional; Region: PRK07726 768492008781 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 768492008782 active site 768492008783 putative interdomain interaction site [polypeptide binding]; other site 768492008784 putative metal-binding site [ion binding]; other site 768492008785 putative nucleotide binding site [chemical binding]; other site 768492008786 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 768492008787 domain I; other site 768492008788 DNA binding groove [nucleotide binding] 768492008789 phosphate binding site [ion binding]; other site 768492008790 domain II; other site 768492008791 domain III; other site 768492008792 nucleotide binding site [chemical binding]; other site 768492008793 catalytic site [active] 768492008794 domain IV; other site 768492008795 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 768492008796 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 768492008797 active site residue [active] 768492008798 selenophosphate synthetase; Provisional; Region: PRK00943 768492008799 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 768492008800 dimerization interface [polypeptide binding]; other site 768492008801 putative ATP binding site [chemical binding]; other site 768492008802 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 768492008803 putative FMN binding site [chemical binding]; other site 768492008804 protease 4; Provisional; Region: PRK10949 768492008805 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 768492008806 tandem repeat interface [polypeptide binding]; other site 768492008807 oligomer interface [polypeptide binding]; other site 768492008808 active site residues [active] 768492008809 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 768492008810 tandem repeat interface [polypeptide binding]; other site 768492008811 oligomer interface [polypeptide binding]; other site 768492008812 active site residues [active] 768492008813 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 768492008814 active site 768492008815 homodimer interface [polypeptide binding]; other site 768492008816 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 768492008817 Isochorismatase family; Region: Isochorismatase; pfam00857 768492008818 catalytic triad [active] 768492008819 metal binding site [ion binding]; metal-binding site 768492008820 conserved cis-peptide bond; other site 768492008821 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 768492008822 Glyco_18 domain; Region: Glyco_18; smart00636 768492008823 active site 768492008824 Protein of unknown function (DUF1315); Region: DUF1315; pfam07023 768492008825 methionine sulfoxide reductase B; Provisional; Region: PRK00222 768492008826 SelR domain; Region: SelR; pfam01641 768492008827 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 768492008828 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 768492008829 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 768492008830 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 768492008831 active site 768492008832 phosphate binding residues; other site 768492008833 catalytic residues [active] 768492008834 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 768492008835 PrkA family serine protein kinase; Provisional; Region: PRK15455 768492008836 AAA ATPase domain; Region: AAA_16; pfam13191 768492008837 Walker A motif; other site 768492008838 ATP binding site [chemical binding]; other site 768492008839 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 768492008840 hypothetical protein; Provisional; Region: PRK05325 768492008841 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768492008842 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492008843 Coenzyme A binding pocket [chemical binding]; other site 768492008844 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 768492008845 intracellular protease, PfpI family; Region: PfpI; TIGR01382 768492008846 conserved cys residue [active] 768492008847 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 768492008848 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 768492008849 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 768492008850 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768492008851 N-terminal plug; other site 768492008852 ligand-binding site [chemical binding]; other site 768492008853 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768492008854 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 768492008855 Walker A/P-loop; other site 768492008856 ATP binding site [chemical binding]; other site 768492008857 Q-loop/lid; other site 768492008858 ABC transporter signature motif; other site 768492008859 Walker B; other site 768492008860 D-loop; other site 768492008861 H-loop/switch region; other site 768492008862 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 768492008863 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768492008864 Walker A/P-loop; other site 768492008865 ATP binding site [chemical binding]; other site 768492008866 Q-loop/lid; other site 768492008867 ABC transporter signature motif; other site 768492008868 Walker B; other site 768492008869 D-loop; other site 768492008870 H-loop/switch region; other site 768492008871 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768492008872 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 768492008873 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 768492008874 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 768492008875 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 768492008876 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 768492008877 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 768492008878 active site 768492008879 substrate binding site [chemical binding]; other site 768492008880 catalytic site [active] 768492008881 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492008882 putative substrate translocation pore; other site 768492008883 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768492008884 alanine racemase; Reviewed; Region: dadX; PRK03646 768492008885 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 768492008886 active site 768492008887 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768492008888 substrate binding site [chemical binding]; other site 768492008889 catalytic residues [active] 768492008890 dimer interface [polypeptide binding]; other site 768492008891 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 768492008892 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768492008893 hydroxyglutarate oxidase; Provisional; Region: PRK11728 768492008894 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 768492008895 active site 768492008896 catalytic triad [active] 768492008897 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 768492008898 Baseplate J-like protein; Region: Baseplate_J; cl01294 768492008899 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 768492008900 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 768492008901 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768492008902 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768492008903 catalytic residue [active] 768492008904 Protein of unknown function (DUF3277); Region: DUF3277; pfam11681 768492008905 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 768492008906 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 768492008907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834 768492008908 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 768492008909 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 768492008910 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 768492008911 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 768492008912 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 768492008913 Terminase small subunit; Region: Terminase_2; pfam03592 768492008914 Predicted chitinase [General function prediction only]; Region: COG3179 768492008915 catalytic residue [active] 768492008916 Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106 768492008917 Poxvirus G5 protein; Region: Pox_G5; pfam04599 768492008918 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 768492008919 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 768492008920 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 768492008921 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 768492008922 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 768492008923 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 768492008924 cofactor binding site; other site 768492008925 DNA binding site [nucleotide binding] 768492008926 substrate interaction site [chemical binding]; other site 768492008927 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 768492008928 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 768492008929 replicative DNA helicase; Region: DnaB; TIGR00665 768492008930 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 768492008931 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 768492008932 Walker A motif; other site 768492008933 ATP binding site [chemical binding]; other site 768492008934 Walker B motif; other site 768492008935 DNA binding loops [nucleotide binding] 768492008936 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 768492008937 transcriptional repressor DicA; Reviewed; Region: PRK09706 768492008938 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492008939 non-specific DNA binding site [nucleotide binding]; other site 768492008940 salt bridge; other site 768492008941 sequence-specific DNA binding site [nucleotide binding]; other site 768492008942 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 768492008943 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 768492008944 Excisionase-like protein; Region: Exc; pfam07825 768492008945 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 768492008946 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768492008947 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 768492008948 dimer interface [polypeptide binding]; other site 768492008949 active site 768492008950 Int/Topo IB signature motif; other site 768492008951 SpoVR family protein; Provisional; Region: PRK11767 768492008952 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 768492008953 fatty acid metabolism regulator; Provisional; Region: PRK04984 768492008954 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492008955 DNA-binding site [nucleotide binding]; DNA binding site 768492008956 FadR C-terminal domain; Region: FadR_C; pfam07840 768492008957 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 768492008958 disulfide bond formation protein B; Provisional; Region: PRK01749 768492008959 hypothetical protein; Provisional; Region: PRK05170 768492008960 CsbD-like; Region: CsbD; cl17424 768492008961 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 768492008962 hypothetical protein; Provisional; Region: PRK10691 768492008963 Transglycosylase SLT domain; Region: SLT_2; pfam13406 768492008964 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768492008965 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768492008966 catalytic residue [active] 768492008967 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 768492008968 septum formation inhibitor; Reviewed; Region: minC; PRK03511 768492008969 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 768492008970 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 768492008971 cell division inhibitor MinD; Provisional; Region: PRK10818 768492008972 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 768492008973 Switch I; other site 768492008974 Switch II; other site 768492008975 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 768492008976 ribonuclease D; Provisional; Region: PRK10829 768492008977 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 768492008978 catalytic site [active] 768492008979 putative active site [active] 768492008980 putative substrate binding site [chemical binding]; other site 768492008981 Helicase and RNase D C-terminal; Region: HRDC; smart00341 768492008982 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 768492008983 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 768492008984 acyl-activating enzyme (AAE) consensus motif; other site 768492008985 putative AMP binding site [chemical binding]; other site 768492008986 putative active site [active] 768492008987 putative CoA binding site [chemical binding]; other site 768492008988 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 768492008989 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 768492008990 Glycoprotease family; Region: Peptidase_M22; pfam00814 768492008991 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 768492008992 DEAD/DEAH box helicase; Region: DEAD; pfam00270 768492008993 ATP binding site [chemical binding]; other site 768492008994 DEAD_2; Region: DEAD_2; pfam06733 768492008995 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 768492008996 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 768492008997 homotrimer interaction site [polypeptide binding]; other site 768492008998 putative active site [active] 768492008999 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 768492009000 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 768492009001 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 768492009002 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 768492009003 active site 768492009004 intersubunit interface [polypeptide binding]; other site 768492009005 catalytic residue [active] 768492009006 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 768492009007 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 768492009008 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 768492009009 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 768492009010 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768492009011 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768492009012 putative active site [active] 768492009013 pyruvate kinase; Provisional; Region: PRK05826 768492009014 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 768492009015 domain interfaces; other site 768492009016 active site 768492009017 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 768492009018 Leucine-rich repeats; other site 768492009019 Substrate binding site [chemical binding]; other site 768492009020 Leucine rich repeat; Region: LRR_8; pfam13855 768492009021 Leucine rich repeat; Region: LRR_8; pfam13855 768492009022 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 768492009023 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 768492009024 putative acyl-acceptor binding pocket; other site 768492009025 putative peptidase; Provisional; Region: PRK11649 768492009026 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 768492009027 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768492009028 Peptidase family M23; Region: Peptidase_M23; pfam01551 768492009029 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 768492009030 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 768492009031 metal binding site [ion binding]; metal-binding site 768492009032 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 768492009033 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 768492009034 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768492009035 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 768492009036 ABC-ATPase subunit interface; other site 768492009037 dimer interface [polypeptide binding]; other site 768492009038 putative PBP binding regions; other site 768492009039 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 768492009040 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492009041 Walker A motif; other site 768492009042 ATP binding site [chemical binding]; other site 768492009043 Walker B motif; other site 768492009044 arginine finger; other site 768492009045 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 768492009046 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 768492009047 RuvA N terminal domain; Region: RuvA_N; pfam01330 768492009048 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 768492009049 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 768492009050 active site 768492009051 putative DNA-binding cleft [nucleotide binding]; other site 768492009052 dimer interface [polypeptide binding]; other site 768492009053 hypothetical protein; Validated; Region: PRK00110 768492009054 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 768492009055 nudix motif; other site 768492009056 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 768492009057 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 768492009058 dimer interface [polypeptide binding]; other site 768492009059 anticodon binding site; other site 768492009060 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 768492009061 homodimer interface [polypeptide binding]; other site 768492009062 motif 1; other site 768492009063 active site 768492009064 motif 2; other site 768492009065 GAD domain; Region: GAD; pfam02938 768492009066 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 768492009067 active site 768492009068 motif 3; other site 768492009069 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 768492009070 Isochorismatase family; Region: Isochorismatase; pfam00857 768492009071 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 768492009072 catalytic triad [active] 768492009073 conserved cis-peptide bond; other site 768492009074 hypothetical protein; Provisional; Region: PRK10302 768492009075 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 768492009076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492009077 S-adenosylmethionine binding site [chemical binding]; other site 768492009078 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492009079 S-adenosylmethionine binding site [chemical binding]; other site 768492009080 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 768492009081 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 768492009082 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 768492009083 copper homeostasis protein CutC; Provisional; Region: PRK11572 768492009084 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 768492009085 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492009086 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492009087 homodimer interface [polypeptide binding]; other site 768492009088 catalytic residue [active] 768492009089 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 768492009090 putative metal binding site [ion binding]; other site 768492009091 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 768492009092 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 768492009093 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 768492009094 active site 768492009095 HIGH motif; other site 768492009096 KMSK motif region; other site 768492009097 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 768492009098 tRNA binding surface [nucleotide binding]; other site 768492009099 anticodon binding site; other site 768492009100 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 768492009101 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 768492009102 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768492009103 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768492009104 hypothetical protein; Provisional; Region: PRK11239 768492009105 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 768492009106 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 768492009107 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 768492009108 multidrug resistance protein MdtH; Provisional; Region: PRK11646 768492009109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492009110 putative substrate translocation pore; other site 768492009111 glutaredoxin 2; Provisional; Region: PRK10387 768492009112 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 768492009113 C-terminal domain interface [polypeptide binding]; other site 768492009114 GSH binding site (G-site) [chemical binding]; other site 768492009115 catalytic residues [active] 768492009116 putative dimer interface [polypeptide binding]; other site 768492009117 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 768492009118 N-terminal domain interface [polypeptide binding]; other site 768492009119 ABC1 family; Region: ABC1; cl17513 768492009120 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 768492009121 lipoprotein; Provisional; Region: PRK10598 768492009122 hypothetical protein; Provisional; Region: PRK13680 768492009123 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 768492009124 YebG protein; Region: YebG; pfam07130 768492009125 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 768492009126 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 768492009127 ATP binding site [chemical binding]; other site 768492009128 Mg++ binding site [ion binding]; other site 768492009129 motif III; other site 768492009130 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768492009131 nucleotide binding region [chemical binding]; other site 768492009132 ATP-binding site [chemical binding]; other site 768492009133 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 768492009134 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 768492009135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492009136 ATP-grasp domain; Region: ATP-grasp; pfam02222 768492009137 hypothetical protein; Provisional; Region: PRK05114 768492009138 putative glycosyl transferase; Provisional; Region: PRK10073 768492009139 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 768492009140 active site 768492009141 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 768492009142 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 768492009143 chorismate binding enzyme; Region: Chorismate_bind; cl10555 768492009144 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 768492009145 putative active site [active] 768492009146 putative CoA binding site [chemical binding]; other site 768492009147 nudix motif; other site 768492009148 metal binding site [ion binding]; metal-binding site 768492009149 L-serine deaminase; Provisional; Region: PRK15023 768492009150 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 768492009151 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 768492009152 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 768492009153 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768492009154 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 768492009155 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 768492009156 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 768492009157 Transporter associated domain; Region: CorC_HlyC; smart01091 768492009158 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 768492009159 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 768492009160 active pocket/dimerization site; other site 768492009161 active site 768492009162 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 768492009163 active site 768492009164 phosphorylation site [posttranslational modification] 768492009165 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 768492009166 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 768492009167 hypothetical protein; Provisional; Region: PRK02913 768492009168 Domain of unknown function DUF; Region: DUF204; pfam02659 768492009169 Domain of unknown function DUF; Region: DUF204; pfam02659 768492009170 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 768492009171 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492009172 putative substrate translocation pore; other site 768492009173 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768492009174 dimerization interface [polypeptide binding]; other site 768492009175 putative DNA binding site [nucleotide binding]; other site 768492009176 Transcriptional regulators [Transcription]; Region: MarR; COG1846 768492009177 putative Zn2+ binding site [ion binding]; other site 768492009178 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 768492009179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492009180 S-adenosylmethionine binding site [chemical binding]; other site 768492009181 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 768492009182 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 768492009183 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768492009184 DNA-binding site [nucleotide binding]; DNA binding site 768492009185 RNA-binding motif; other site 768492009186 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 768492009187 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 768492009188 aromatic amino acid transporter; Provisional; Region: PRK10238 768492009189 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 768492009190 Protein of unknown function (DUF2591); Region: DUF2591; pfam10765 768492009191 FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244 768492009192 dimer interface [polypeptide binding]; other site 768492009193 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768492009194 Mn binding site [ion binding]; other site 768492009195 K binding site [ion binding]; other site 768492009196 YebO-like protein; Region: YebO; pfam13974 768492009197 YobH-like protein; Region: YobH; pfam13996 768492009198 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 768492009199 YccJ-like protein; Region: YccJ; cl08091 768492009200 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 768492009201 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492009202 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 768492009203 Pirin; Region: Pirin; pfam02678 768492009204 Pirin-related protein [General function prediction only]; Region: COG1741 768492009205 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 768492009206 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 768492009207 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768492009208 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 768492009209 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 768492009210 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 768492009211 trimer interface [polypeptide binding]; other site 768492009212 eyelet of channel; other site 768492009213 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 768492009214 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 768492009215 putative active site [active] 768492009216 Zn binding site [ion binding]; other site 768492009217 succinylarginine dihydrolase; Provisional; Region: PRK13281 768492009218 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 768492009219 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 768492009220 NAD(P) binding site [chemical binding]; other site 768492009221 catalytic residues [active] 768492009222 arginine succinyltransferase; Provisional; Region: PRK10456 768492009223 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 768492009224 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 768492009225 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768492009226 inhibitor-cofactor binding pocket; inhibition site 768492009227 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492009228 catalytic residue [active] 768492009229 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 768492009230 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 768492009231 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 768492009232 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768492009233 Walker A/P-loop; other site 768492009234 ATP binding site [chemical binding]; other site 768492009235 Q-loop/lid; other site 768492009236 ABC transporter signature motif; other site 768492009237 Walker B; other site 768492009238 D-loop; other site 768492009239 H-loop/switch region; other site 768492009240 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 768492009241 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768492009242 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 768492009243 Walker A/P-loop; other site 768492009244 ATP binding site [chemical binding]; other site 768492009245 Q-loop/lid; other site 768492009246 ABC transporter signature motif; other site 768492009247 Walker B; other site 768492009248 D-loop; other site 768492009249 H-loop/switch region; other site 768492009250 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 768492009251 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 768492009252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492009253 dimer interface [polypeptide binding]; other site 768492009254 conserved gate region; other site 768492009255 putative PBP binding loops; other site 768492009256 ABC-ATPase subunit interface; other site 768492009257 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 768492009258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492009259 dimer interface [polypeptide binding]; other site 768492009260 conserved gate region; other site 768492009261 putative PBP binding loops; other site 768492009262 ABC-ATPase subunit interface; other site 768492009263 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 768492009264 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 768492009265 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768492009266 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492009267 DNA-binding site [nucleotide binding]; DNA binding site 768492009268 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492009269 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492009270 homodimer interface [polypeptide binding]; other site 768492009271 catalytic residue [active] 768492009272 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 768492009273 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 768492009274 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 768492009275 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 768492009276 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 768492009277 Fatty acid desaturase; Region: FA_desaturase; pfam00487 768492009278 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 768492009279 putative di-iron ligands [ion binding]; other site 768492009280 Fatty acid desaturase; Region: FA_desaturase; pfam00487 768492009281 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 768492009282 putative di-iron ligands [ion binding]; other site 768492009283 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 768492009284 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 768492009285 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 768492009286 active site 768492009287 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 768492009288 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 768492009289 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 768492009290 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 768492009291 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768492009292 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492009293 NAD(P) binding site [chemical binding]; other site 768492009294 active site 768492009295 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 768492009296 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 768492009297 dimer interface [polypeptide binding]; other site 768492009298 active site 768492009299 CoA binding pocket [chemical binding]; other site 768492009300 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 768492009301 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 768492009302 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 768492009303 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 768492009304 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 768492009305 [4Fe-4S] binding site [ion binding]; other site 768492009306 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 768492009307 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 768492009308 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 768492009309 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 768492009310 molybdopterin cofactor binding site; other site 768492009311 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 768492009312 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 768492009313 active site 768492009314 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 768492009315 active site 768492009316 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 768492009317 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 768492009318 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 768492009319 active site 768492009320 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 768492009321 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 768492009322 putative ADP-binding pocket [chemical binding]; other site 768492009323 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768492009324 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 768492009325 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 768492009326 active site 768492009327 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 768492009328 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 768492009329 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 768492009330 tyrosine kinase; Provisional; Region: PRK11519 768492009331 Chain length determinant protein; Region: Wzz; pfam02706 768492009332 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 768492009333 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 768492009334 Nucleotide binding site [chemical binding]; other site 768492009335 DTAP/Switch II; other site 768492009336 Switch I; other site 768492009337 polysaccharide export protein Wza; Provisional; Region: PRK15078 768492009338 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 768492009339 SLBB domain; Region: SLBB; pfam10531 768492009340 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 768492009341 Mg++ binding site [ion binding]; other site 768492009342 putative catalytic motif [active] 768492009343 substrate binding site [chemical binding]; other site 768492009344 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492009345 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 768492009346 NAD(P) binding site [chemical binding]; other site 768492009347 active site 768492009348 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768492009349 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768492009350 DNA binding site [nucleotide binding] 768492009351 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 768492009352 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 768492009353 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 768492009354 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768492009355 dimerization interface [polypeptide binding]; other site 768492009356 Histidine kinase; Region: HisKA_3; pfam07730 768492009357 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492009358 ATP binding site [chemical binding]; other site 768492009359 Mg2+ binding site [ion binding]; other site 768492009360 G-X-G motif; other site 768492009361 transcriptional regulator NarL; Provisional; Region: PRK10651 768492009362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492009363 active site 768492009364 phosphorylation site [posttranslational modification] 768492009365 intermolecular recognition site; other site 768492009366 dimerization interface [polypeptide binding]; other site 768492009367 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492009368 DNA binding residues [nucleotide binding] 768492009369 dimerization interface [polypeptide binding]; other site 768492009370 putative invasin; Provisional; Region: PRK10177 768492009371 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 768492009372 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 768492009373 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 768492009374 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 768492009375 substrate binding site [chemical binding]; other site 768492009376 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 768492009377 active site 768492009378 SAM binding site [chemical binding]; other site 768492009379 homodimer interface [polypeptide binding]; other site 768492009380 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 768492009381 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 768492009382 [4Fe-4S] binding site [ion binding]; other site 768492009383 molybdopterin cofactor binding site; other site 768492009384 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 768492009385 molybdopterin cofactor binding site; other site 768492009386 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 768492009387 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 768492009388 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768492009389 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768492009390 nitrite reductase subunit NirD; Provisional; Region: PRK14989 768492009391 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768492009392 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 768492009393 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 768492009394 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 768492009395 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 768492009396 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 768492009397 Walker A/P-loop; other site 768492009398 ATP binding site [chemical binding]; other site 768492009399 Q-loop/lid; other site 768492009400 ABC transporter signature motif; other site 768492009401 Walker B; other site 768492009402 D-loop; other site 768492009403 H-loop/switch region; other site 768492009404 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 768492009405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492009406 dimer interface [polypeptide binding]; other site 768492009407 conserved gate region; other site 768492009408 putative PBP binding loops; other site 768492009409 ABC-ATPase subunit interface; other site 768492009410 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 768492009411 NMT1-like family; Region: NMT1_2; pfam13379 768492009412 Nitrate and nitrite sensing; Region: NIT; pfam08376 768492009413 ANTAR domain; Region: ANTAR; pfam03861 768492009414 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 768492009415 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 768492009416 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768492009417 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768492009418 Walker A/P-loop; other site 768492009419 ATP binding site [chemical binding]; other site 768492009420 Q-loop/lid; other site 768492009421 ABC transporter signature motif; other site 768492009422 Walker B; other site 768492009423 D-loop; other site 768492009424 H-loop/switch region; other site 768492009425 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768492009426 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 768492009427 Walker A/P-loop; other site 768492009428 ATP binding site [chemical binding]; other site 768492009429 Q-loop/lid; other site 768492009430 ABC transporter signature motif; other site 768492009431 Walker B; other site 768492009432 D-loop; other site 768492009433 H-loop/switch region; other site 768492009434 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 768492009435 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492009436 dimer interface [polypeptide binding]; other site 768492009437 conserved gate region; other site 768492009438 putative PBP binding loops; other site 768492009439 ABC-ATPase subunit interface; other site 768492009440 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 768492009441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492009442 dimer interface [polypeptide binding]; other site 768492009443 conserved gate region; other site 768492009444 putative PBP binding loops; other site 768492009445 ABC-ATPase subunit interface; other site 768492009446 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 768492009447 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 768492009448 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 768492009449 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 768492009450 substrate binding site [chemical binding]; other site 768492009451 dimerization interface [polypeptide binding]; other site 768492009452 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 768492009453 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 768492009454 putative active site pocket [active] 768492009455 dimerization interface [polypeptide binding]; other site 768492009456 putative catalytic residue [active] 768492009457 cation transport regulator; Reviewed; Region: chaB; PRK09582 768492009458 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 768492009459 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 768492009460 FAD binding pocket [chemical binding]; other site 768492009461 FAD binding motif [chemical binding]; other site 768492009462 phosphate binding motif [ion binding]; other site 768492009463 NAD binding pocket [chemical binding]; other site 768492009464 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 768492009465 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 768492009466 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 768492009467 hypothetical protein; Provisional; Region: PRK10536 768492009468 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 768492009469 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 768492009470 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768492009471 N-terminal plug; other site 768492009472 ligand-binding site [chemical binding]; other site 768492009473 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 768492009474 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 768492009475 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 768492009476 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 768492009477 Imelysin; Region: Peptidase_M75; pfam09375 768492009478 Iron permease FTR1 family; Region: FTR1; cl00475 768492009479 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 768492009480 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 768492009481 Na binding site [ion binding]; other site 768492009482 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 768492009483 Predicted transcriptional regulator [Transcription]; Region: COG3905 768492009484 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 768492009485 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 768492009486 Glutamate binding site [chemical binding]; other site 768492009487 NAD binding site [chemical binding]; other site 768492009488 catalytic residues [active] 768492009489 YcfA-like protein; Region: YcfA; pfam07927 768492009490 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 768492009491 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 768492009492 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 768492009493 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 768492009494 Walker A/P-loop; other site 768492009495 ATP binding site [chemical binding]; other site 768492009496 Q-loop/lid; other site 768492009497 ABC transporter signature motif; other site 768492009498 Walker B; other site 768492009499 D-loop; other site 768492009500 H-loop/switch region; other site 768492009501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492009502 dimer interface [polypeptide binding]; other site 768492009503 conserved gate region; other site 768492009504 putative PBP binding loops; other site 768492009505 ABC-ATPase subunit interface; other site 768492009506 cystine transporter subunit; Provisional; Region: PRK11260 768492009507 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492009508 substrate binding pocket [chemical binding]; other site 768492009509 membrane-bound complex binding site; other site 768492009510 hinge residues; other site 768492009511 D-cysteine desulfhydrase; Validated; Region: PRK03910 768492009512 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 768492009513 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492009514 catalytic residue [active] 768492009515 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 768492009516 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 768492009517 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768492009518 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 768492009519 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768492009520 DNA binding residues [nucleotide binding] 768492009521 flagellin; Validated; Region: PRK06819 768492009522 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 768492009523 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 768492009524 flagellar capping protein; Reviewed; Region: fliD; PRK08032 768492009525 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 768492009526 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 768492009527 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 768492009528 flagellar protein FliS; Validated; Region: fliS; PRK05685 768492009529 Flagellar protein FliT; Region: FliT; cl05125 768492009530 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768492009531 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492009532 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 768492009533 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 768492009534 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 768492009535 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 768492009536 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 768492009537 FliG C-terminal domain; Region: FliG_C; pfam01706 768492009538 flagellar assembly protein H; Validated; Region: fliH; PRK05687 768492009539 Flagellar assembly protein FliH; Region: FliH; pfam02108 768492009540 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 768492009541 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 768492009542 Walker A motif/ATP binding site; other site 768492009543 Walker B motif; other site 768492009544 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 768492009545 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 768492009546 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 768492009547 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 768492009548 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 768492009549 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 768492009550 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 768492009551 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 768492009552 Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190 768492009553 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 768492009554 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 768492009555 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 768492009556 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 768492009557 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 768492009558 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 768492009559 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 768492009560 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 768492009561 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 768492009562 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 768492009563 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 768492009564 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 768492009565 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 768492009566 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 768492009567 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 768492009568 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 768492009569 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 768492009570 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 768492009571 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 768492009572 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 768492009573 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 768492009574 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 768492009575 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 768492009576 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 768492009577 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 768492009578 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 768492009579 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 768492009580 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 768492009581 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 768492009582 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 768492009583 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 768492009584 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 768492009585 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 768492009586 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 768492009587 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 768492009588 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 768492009589 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 768492009590 FlgN protein; Region: FlgN; cl09176 768492009591 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 768492009592 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 768492009593 Predicted transcriptional regulator [Transcription]; Region: COG2944 768492009594 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492009595 non-specific DNA binding site [nucleotide binding]; other site 768492009596 salt bridge; other site 768492009597 sequence-specific DNA binding site [nucleotide binding]; other site 768492009598 Flagellar protein FlhE; Region: FlhE; pfam06366 768492009599 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 768492009600 FHIPEP family; Region: FHIPEP; pfam00771 768492009601 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK12468 768492009602 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 768492009603 chemotaxis regulator CheZ; Provisional; Region: PRK11166 768492009604 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 768492009605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492009606 active site 768492009607 phosphorylation site [posttranslational modification] 768492009608 intermolecular recognition site; other site 768492009609 dimerization interface [polypeptide binding]; other site 768492009610 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 768492009611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492009612 active site 768492009613 phosphorylation site [posttranslational modification] 768492009614 intermolecular recognition site; other site 768492009615 dimerization interface [polypeptide binding]; other site 768492009616 CheB methylesterase; Region: CheB_methylest; pfam01339 768492009617 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 768492009618 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 768492009619 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492009620 methyl-accepting protein IV; Provisional; Region: PRK09793 768492009621 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 768492009622 dimer interface [polypeptide binding]; other site 768492009623 ligand binding site [chemical binding]; other site 768492009624 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768492009625 dimerization interface [polypeptide binding]; other site 768492009626 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768492009627 dimer interface [polypeptide binding]; other site 768492009628 putative CheW interface [polypeptide binding]; other site 768492009629 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 768492009630 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 768492009631 dimer interface [polypeptide binding]; other site 768492009632 ligand binding site [chemical binding]; other site 768492009633 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768492009634 dimerization interface [polypeptide binding]; other site 768492009635 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768492009636 dimer interface [polypeptide binding]; other site 768492009637 putative CheW interface [polypeptide binding]; other site 768492009638 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 768492009639 putative CheA interaction surface; other site 768492009640 chemotaxis protein CheA; Provisional; Region: PRK10547 768492009641 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 768492009642 putative binding surface; other site 768492009643 active site 768492009644 CheY binding; Region: CheY-binding; pfam09078 768492009645 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 768492009646 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492009647 ATP binding site [chemical binding]; other site 768492009648 Mg2+ binding site [ion binding]; other site 768492009649 G-X-G motif; other site 768492009650 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 768492009651 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 768492009652 flagellar motor protein MotA; Validated; Region: PRK09110 768492009653 transcriptional activator FlhC; Provisional; Region: PRK12722 768492009654 transcriptional activator FlhD; Provisional; Region: PRK02909 768492009655 Haemolysin expression modulating protein; Region: HHA; cl11501 768492009656 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 768492009657 Ligand Binding Site [chemical binding]; other site 768492009658 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 768492009659 Prostaglandin dehydrogenases; Region: PGDH; cd05288 768492009660 NAD(P) binding site [chemical binding]; other site 768492009661 substrate binding site [chemical binding]; other site 768492009662 dimer interface [polypeptide binding]; other site 768492009663 DNA gyrase inhibitor; Provisional; Region: PRK10016 768492009664 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 768492009665 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 768492009666 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 768492009667 active site 768492009668 DNA binding site [nucleotide binding] 768492009669 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 768492009670 Fungal chitosanase of glycosyl hydrolase group 75; Region: Glyco_hydro_75; pfam07335 768492009671 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 768492009672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492009673 putative substrate translocation pore; other site 768492009674 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 768492009675 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 768492009676 dimerization domain [polypeptide binding]; other site 768492009677 dimer interface [polypeptide binding]; other site 768492009678 catalytic residues [active] 768492009679 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 768492009680 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 768492009681 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 768492009682 Catalytic site [active] 768492009683 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 768492009684 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492009685 active site 768492009686 phosphorylation site [posttranslational modification] 768492009687 intermolecular recognition site; other site 768492009688 dimerization interface [polypeptide binding]; other site 768492009689 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492009690 DNA binding residues [nucleotide binding] 768492009691 dimerization interface [polypeptide binding]; other site 768492009692 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 768492009693 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 768492009694 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 768492009695 Transmembrane secretion effector; Region: MFS_3; pfam05977 768492009696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492009697 putative substrate translocation pore; other site 768492009698 DoxX; Region: DoxX; pfam07681 768492009699 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 768492009700 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 768492009701 active site 768492009702 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 768492009703 Isochorismatase family; Region: Isochorismatase; pfam00857 768492009704 catalytic triad [active] 768492009705 dimer interface [polypeptide binding]; other site 768492009706 conserved cis-peptide bond; other site 768492009707 Protein of unknown function (DUF1427); Region: DUF1427; cl01771 768492009708 Response regulator receiver domain; Region: Response_reg; pfam00072 768492009709 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492009710 active site 768492009711 phosphorylation site [posttranslational modification] 768492009712 intermolecular recognition site; other site 768492009713 dimerization interface [polypeptide binding]; other site 768492009714 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 768492009715 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 768492009716 substrate binding site [chemical binding]; other site 768492009717 activation loop (A-loop); other site 768492009718 Predicted ATPase [General function prediction only]; Region: COG3899 768492009719 AAA ATPase domain; Region: AAA_16; pfam13191 768492009720 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 768492009721 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 768492009722 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768492009723 PAS fold; Region: PAS_3; pfam08447 768492009724 putative active site [active] 768492009725 heme pocket [chemical binding]; other site 768492009726 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492009727 dimer interface [polypeptide binding]; other site 768492009728 phosphorylation site [posttranslational modification] 768492009729 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492009730 ATP binding site [chemical binding]; other site 768492009731 Mg2+ binding site [ion binding]; other site 768492009732 G-X-G motif; other site 768492009733 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 768492009734 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 768492009735 Bacterial transcriptional regulator; Region: IclR; pfam01614 768492009736 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 768492009737 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 768492009738 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 768492009739 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 768492009740 dimer interface [polypeptide binding]; other site 768492009741 active site 768492009742 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 768492009743 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 768492009744 ArsC family; Region: ArsC; pfam03960 768492009745 catalytic residues [active] 768492009746 arsenical pump membrane protein; Provisional; Region: PRK15445 768492009747 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 768492009748 transmembrane helices; other site 768492009749 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768492009750 dimerization interface [polypeptide binding]; other site 768492009751 putative DNA binding site [nucleotide binding]; other site 768492009752 putative Zn2+ binding site [ion binding]; other site 768492009753 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 768492009754 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 768492009755 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492009756 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492009757 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492009758 putative effector binding pocket; other site 768492009759 dimerization interface [polypeptide binding]; other site 768492009760 Protein of unknown function, DUF606; Region: DUF606; pfam04657 768492009761 Protein of unknown function, DUF606; Region: DUF606; pfam04657 768492009762 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 768492009763 magnesium-transporting ATPase; Provisional; Region: PRK15122 768492009764 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 768492009765 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768492009766 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 768492009767 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492009768 motif II; other site 768492009769 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 768492009770 magnesium transport protein MgtC; Provisional; Region: PRK15385 768492009771 MgtC family; Region: MgtC; pfam02308 768492009772 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 768492009773 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 768492009774 CoA-transferase family III; Region: CoA_transf_3; pfam02515 768492009775 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768492009776 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492009777 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 768492009778 dimerization interface [polypeptide binding]; other site 768492009779 substrate binding pocket [chemical binding]; other site 768492009780 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 768492009781 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492009782 catalytic residue [active] 768492009783 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 768492009784 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492009785 DNA binding residues [nucleotide binding] 768492009786 dimerization interface [polypeptide binding]; other site 768492009787 hypothetical protein; Provisional; Region: PRK10708 768492009788 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768492009789 DNA-binding site [nucleotide binding]; DNA binding site 768492009790 RNA-binding motif; other site 768492009791 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 768492009792 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 768492009793 NAD(P) binding site [chemical binding]; other site 768492009794 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 768492009795 putative catalytic site [active] 768492009796 putative metal binding site [ion binding]; other site 768492009797 putative phosphate binding site [ion binding]; other site 768492009798 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 768492009799 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768492009800 NAD(P) binding site [chemical binding]; other site 768492009801 active site 768492009802 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492009803 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492009804 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492009805 putative effector binding pocket; other site 768492009806 dimerization interface [polypeptide binding]; other site 768492009807 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 768492009808 hypothetical protein; Provisional; Region: PRK10457 768492009809 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492009810 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492009811 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 768492009812 putative effector binding pocket; other site 768492009813 putative dimerization interface [polypeptide binding]; other site 768492009814 short chain dehydrogenase; Provisional; Region: PRK12744 768492009815 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 768492009816 NADP binding site [chemical binding]; other site 768492009817 homodimer interface [polypeptide binding]; other site 768492009818 active site 768492009819 substrate binding site [chemical binding]; other site 768492009820 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 768492009821 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768492009822 dimer interface [polypeptide binding]; other site 768492009823 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768492009824 metal binding site [ion binding]; metal-binding site 768492009825 active site 768492009826 I-site; other site 768492009827 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 768492009828 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 768492009829 substrate binding site [chemical binding]; other site 768492009830 dimer interface [polypeptide binding]; other site 768492009831 NADP binding site [chemical binding]; other site 768492009832 catalytic residues [active] 768492009833 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 768492009834 substrate binding site [chemical binding]; other site 768492009835 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 768492009836 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 768492009837 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 768492009838 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 768492009839 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 768492009840 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 768492009841 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 768492009842 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 768492009843 FAD binding pocket [chemical binding]; other site 768492009844 FAD binding motif [chemical binding]; other site 768492009845 phosphate binding motif [ion binding]; other site 768492009846 beta-alpha-beta structure motif; other site 768492009847 NAD(p) ribose binding residues [chemical binding]; other site 768492009848 NAD binding pocket [chemical binding]; other site 768492009849 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 768492009850 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768492009851 catalytic loop [active] 768492009852 iron binding site [ion binding]; other site 768492009853 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 768492009854 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768492009855 substrate binding site [chemical binding]; other site 768492009856 oxyanion hole (OAH) forming residues; other site 768492009857 trimer interface [polypeptide binding]; other site 768492009858 enoyl-CoA hydratase; Provisional; Region: PRK08140 768492009859 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768492009860 substrate binding site [chemical binding]; other site 768492009861 oxyanion hole (OAH) forming residues; other site 768492009862 trimer interface [polypeptide binding]; other site 768492009863 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 768492009864 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 768492009865 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768492009866 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768492009867 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 768492009868 CoenzymeA binding site [chemical binding]; other site 768492009869 subunit interaction site [polypeptide binding]; other site 768492009870 PHB binding site; other site 768492009871 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 768492009872 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 768492009873 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 768492009874 active site 768492009875 AMP binding site [chemical binding]; other site 768492009876 homodimer interface [polypeptide binding]; other site 768492009877 acyl-activating enzyme (AAE) consensus motif; other site 768492009878 CoA binding site [chemical binding]; other site 768492009879 PaaX-like protein; Region: PaaX; pfam07848 768492009880 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 768492009881 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 768492009882 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 768492009883 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 768492009884 putative trimer interface [polypeptide binding]; other site 768492009885 putative metal binding site [ion binding]; other site 768492009886 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768492009887 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492009888 DNA-binding site [nucleotide binding]; DNA binding site 768492009889 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492009890 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492009891 homodimer interface [polypeptide binding]; other site 768492009892 catalytic residue [active] 768492009893 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 768492009894 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 768492009895 conserved cys residue [active] 768492009896 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492009897 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 768492009898 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 768492009899 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 768492009900 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 768492009901 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492009902 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492009903 homodimer interface [polypeptide binding]; other site 768492009904 catalytic residue [active] 768492009905 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 768492009906 homotrimer interaction site [polypeptide binding]; other site 768492009907 putative active site [active] 768492009908 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768492009909 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 768492009910 LysR family transcriptional regulator; Provisional; Region: PRK14997 768492009911 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492009912 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 768492009913 putative effector binding pocket; other site 768492009914 putative dimerization interface [polypeptide binding]; other site 768492009915 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 768492009916 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 768492009917 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 768492009918 putative N-terminal domain interface [polypeptide binding]; other site 768492009919 putative dimer interface [polypeptide binding]; other site 768492009920 putative substrate binding pocket (H-site) [chemical binding]; other site 768492009921 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 768492009922 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 768492009923 Glycogen synthesis protein; Region: GlgS; cl11663 768492009924 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 768492009925 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 768492009926 tetramerization interface [polypeptide binding]; other site 768492009927 NAD(P) binding site [chemical binding]; other site 768492009928 catalytic residues [active] 768492009929 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 768492009930 dimer interface [polypeptide binding]; other site 768492009931 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768492009932 ligand binding site [chemical binding]; other site 768492009933 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 768492009934 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492009935 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492009936 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 768492009937 putative effector binding pocket; other site 768492009938 putative dimerization interface [polypeptide binding]; other site 768492009939 Condensation domain; Region: Condensation; pfam00668 768492009940 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 768492009941 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 768492009942 acyl-activating enzyme (AAE) consensus motif; other site 768492009943 AMP binding site [chemical binding]; other site 768492009944 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768492009945 Condensation domain; Region: Condensation; pfam00668 768492009946 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 768492009947 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 768492009948 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 768492009949 acyl-activating enzyme (AAE) consensus motif; other site 768492009950 AMP binding site [chemical binding]; other site 768492009951 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768492009952 Condensation domain; Region: Condensation; pfam00668 768492009953 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 768492009954 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 768492009955 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 768492009956 acyl-activating enzyme (AAE) consensus motif; other site 768492009957 AMP binding site [chemical binding]; other site 768492009958 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768492009959 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 768492009960 Uncharacterized membrane protein [Function unknown]; Region: COG5427; cl02250 768492009961 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 768492009962 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 768492009963 Trp docking motif [polypeptide binding]; other site 768492009964 putative active site [active] 768492009965 galactoside permease; Reviewed; Region: lacY; PRK09528 768492009966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492009967 putative substrate translocation pore; other site 768492009968 alpha-galactosidase; Provisional; Region: PRK15076 768492009969 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 768492009970 NAD binding site [chemical binding]; other site 768492009971 sugar binding site [chemical binding]; other site 768492009972 divalent metal binding site [ion binding]; other site 768492009973 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 768492009974 dimer interface [polypeptide binding]; other site 768492009975 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768492009976 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768492009977 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492009978 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492009979 MATE family multidrug exporter; Provisional; Region: PRK10189 768492009980 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 768492009981 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 768492009982 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 768492009983 ligand binding site [chemical binding]; other site 768492009984 flexible hinge region; other site 768492009985 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 768492009986 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 768492009987 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 768492009988 ligand binding site [chemical binding]; other site 768492009989 flexible hinge region; other site 768492009990 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 768492009991 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 768492009992 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 768492009993 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 768492009994 putative NAD(P) binding site [chemical binding]; other site 768492009995 short chain dehydrogenase; Provisional; Region: PRK06179 768492009996 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 768492009997 NADP binding site [chemical binding]; other site 768492009998 active site 768492009999 steroid binding site; other site 768492010000 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 768492010001 classical (c) SDRs; Region: SDR_c; cd05233 768492010002 NAD(P) binding site [chemical binding]; other site 768492010003 active site 768492010004 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 768492010005 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 768492010006 FMN binding site [chemical binding]; other site 768492010007 active site 768492010008 substrate binding site [chemical binding]; other site 768492010009 catalytic residue [active] 768492010010 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492010011 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768492010012 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768492010013 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768492010014 metal binding site [ion binding]; metal-binding site 768492010015 active site 768492010016 I-site; other site 768492010017 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 768492010018 active site 768492010019 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 768492010020 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 768492010021 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 768492010022 Uncharacterized conserved protein [Function unknown]; Region: COG5361 768492010023 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 768492010024 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 768492010025 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 768492010026 putative NAD(P) binding site [chemical binding]; other site 768492010027 catalytic Zn binding site [ion binding]; other site 768492010028 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 768492010029 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 768492010030 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492010031 Walker A motif; other site 768492010032 ATP binding site [chemical binding]; other site 768492010033 Walker B motif; other site 768492010034 arginine finger; other site 768492010035 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 768492010036 DNA-binding interface [nucleotide binding]; DNA binding site 768492010037 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768492010038 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492010039 DNA binding site [nucleotide binding] 768492010040 domain linker motif; other site 768492010041 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 768492010042 putative dimerization interface [polypeptide binding]; other site 768492010043 putative ligand binding site [chemical binding]; other site 768492010044 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 768492010045 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 768492010046 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 768492010047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492010048 dimer interface [polypeptide binding]; other site 768492010049 conserved gate region; other site 768492010050 putative PBP binding loops; other site 768492010051 ABC-ATPase subunit interface; other site 768492010052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492010053 dimer interface [polypeptide binding]; other site 768492010054 conserved gate region; other site 768492010055 putative PBP binding loops; other site 768492010056 ABC-ATPase subunit interface; other site 768492010057 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 768492010058 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768492010059 Walker A/P-loop; other site 768492010060 ATP binding site [chemical binding]; other site 768492010061 Q-loop/lid; other site 768492010062 ABC transporter signature motif; other site 768492010063 Walker B; other site 768492010064 D-loop; other site 768492010065 H-loop/switch region; other site 768492010066 TOBE domain; Region: TOBE_2; pfam08402 768492010067 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 768492010068 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 768492010069 active site 768492010070 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 768492010071 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 768492010072 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 768492010073 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 768492010074 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 768492010075 conserved cys residue [active] 768492010076 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492010077 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492010078 short chain dehydrogenase; Provisional; Region: PRK06197 768492010079 NAD(P) binding site [chemical binding]; other site 768492010080 active site 768492010081 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 768492010082 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 768492010083 Putative transcription activator [Transcription]; Region: TenA; COG0819 768492010084 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 768492010085 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 768492010086 Walker A/P-loop; other site 768492010087 ATP binding site [chemical binding]; other site 768492010088 Q-loop/lid; other site 768492010089 ABC transporter signature motif; other site 768492010090 Walker B; other site 768492010091 D-loop; other site 768492010092 H-loop/switch region; other site 768492010093 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 768492010094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492010095 dimer interface [polypeptide binding]; other site 768492010096 conserved gate region; other site 768492010097 putative PBP binding loops; other site 768492010098 ABC-ATPase subunit interface; other site 768492010099 NMT1/THI5 like; Region: NMT1; pfam09084 768492010100 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 768492010101 substrate binding pocket [chemical binding]; other site 768492010102 membrane-bound complex binding site; other site 768492010103 hinge residues; other site 768492010104 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 768492010105 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492010106 substrate binding pocket [chemical binding]; other site 768492010107 membrane-bound complex binding site; other site 768492010108 hinge residues; other site 768492010109 phosphoglycerol transferase I; Provisional; Region: PRK03776 768492010110 AMP nucleosidase; Provisional; Region: PRK08292 768492010111 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 768492010112 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 768492010113 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 768492010114 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492010115 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 768492010116 putative dimerization interface [polypeptide binding]; other site 768492010117 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 768492010118 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492010119 NAD(P) binding site [chemical binding]; other site 768492010120 active site 768492010121 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492010122 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768492010123 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492010124 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 768492010125 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 768492010126 TMP-binding site; other site 768492010127 ATP-binding site [chemical binding]; other site 768492010128 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492010129 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492010130 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 768492010131 putative effector binding pocket; other site 768492010132 putative dimerization interface [polypeptide binding]; other site 768492010133 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768492010134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492010135 putative substrate translocation pore; other site 768492010136 Predicted transcriptional regulators [Transcription]; Region: COG1733 768492010137 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 768492010138 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 768492010139 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 768492010140 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768492010141 putative NAD(P) binding site [chemical binding]; other site 768492010142 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 768492010143 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 768492010144 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 768492010145 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 768492010146 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768492010147 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492010148 catalytic residue [active] 768492010149 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 768492010150 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 768492010151 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 768492010152 active site residue [active] 768492010153 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 768492010154 active site residue [active] 768492010155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492010156 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768492010157 putative substrate translocation pore; other site 768492010158 Serine hydrolase; Region: Ser_hydrolase; pfam06821 768492010159 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768492010160 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768492010161 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768492010162 putative DNA binding site [nucleotide binding]; other site 768492010163 putative Zn2+ binding site [ion binding]; other site 768492010164 AsnC family; Region: AsnC_trans_reg; pfam01037 768492010165 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 768492010166 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 768492010167 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 768492010168 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 768492010169 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 768492010170 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 768492010171 methionine synthase; Provisional; Region: PRK01207 768492010172 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 768492010173 substrate binding site [chemical binding]; other site 768492010174 THF binding site; other site 768492010175 zinc-binding site [ion binding]; other site 768492010176 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 768492010177 substrate binding site [chemical binding]; other site 768492010178 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768492010179 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492010180 citrate-proton symporter; Provisional; Region: PRK15075 768492010181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492010182 putative substrate translocation pore; other site 768492010183 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 768492010184 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 768492010185 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492010186 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492010187 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 768492010188 putative dimerization interface [polypeptide binding]; other site 768492010189 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 768492010190 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 768492010191 intersubunit interface [polypeptide binding]; other site 768492010192 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492010193 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492010194 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 768492010195 putative effector binding pocket; other site 768492010196 putative dimerization interface [polypeptide binding]; other site 768492010197 Restriction endonuclease; Region: Mrr_cat; pfam04471 768492010198 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 768492010199 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768492010200 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768492010201 putative active site [active] 768492010202 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 768492010203 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768492010204 N-terminal plug; other site 768492010205 ligand-binding site [chemical binding]; other site 768492010206 galactoside permease; Reviewed; Region: lacY; PRK09528 768492010207 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492010208 putative substrate translocation pore; other site 768492010209 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 768492010210 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 768492010211 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 768492010212 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 768492010213 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 768492010214 lac repressor; Reviewed; Region: lacI; PRK09526 768492010215 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492010216 DNA binding site [nucleotide binding] 768492010217 domain linker motif; other site 768492010218 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 768492010219 ligand binding site [chemical binding]; other site 768492010220 dimerization interface (open form) [polypeptide binding]; other site 768492010221 dimerization interface (closed form) [polypeptide binding]; other site 768492010222 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768492010223 HAMP domain; Region: HAMP; pfam00672 768492010224 dimerization interface [polypeptide binding]; other site 768492010225 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492010226 dimer interface [polypeptide binding]; other site 768492010227 phosphorylation site [posttranslational modification] 768492010228 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492010229 ATP binding site [chemical binding]; other site 768492010230 Mg2+ binding site [ion binding]; other site 768492010231 G-X-G motif; other site 768492010232 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768492010233 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492010234 DNA binding residues [nucleotide binding] 768492010235 dimerization interface [polypeptide binding]; other site 768492010236 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768492010237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492010238 active site 768492010239 phosphorylation site [posttranslational modification] 768492010240 intermolecular recognition site; other site 768492010241 dimerization interface [polypeptide binding]; other site 768492010242 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768492010243 DNA binding site [nucleotide binding] 768492010244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 768492010245 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 768492010246 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492010247 Coenzyme A binding pocket [chemical binding]; other site 768492010248 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768492010249 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492010250 sequence-specific DNA binding site [nucleotide binding]; other site 768492010251 salt bridge; other site 768492010252 Cupin domain; Region: Cupin_2; pfam07883 768492010253 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 768492010254 putative FMN binding site [chemical binding]; other site 768492010255 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768492010256 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492010257 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492010258 dimerization interface [polypeptide binding]; other site 768492010259 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 768492010260 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768492010261 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 768492010262 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 768492010263 putative active site [active] 768492010264 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 768492010265 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 768492010266 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 768492010267 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 768492010268 active site 768492010269 dimer interface [polypeptide binding]; other site 768492010270 non-prolyl cis peptide bond; other site 768492010271 insertion regions; other site 768492010272 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 768492010273 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492010274 Walker A motif; other site 768492010275 ATP binding site [chemical binding]; other site 768492010276 Walker B motif; other site 768492010277 arginine finger; other site 768492010278 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 768492010279 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 768492010280 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492010281 substrate binding pocket [chemical binding]; other site 768492010282 membrane-bound complex binding site; other site 768492010283 hinge residues; other site 768492010284 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 768492010285 alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030 768492010286 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 768492010287 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 768492010288 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 768492010289 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 768492010290 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768492010291 Walker A/P-loop; other site 768492010292 ATP binding site [chemical binding]; other site 768492010293 Q-loop/lid; other site 768492010294 ABC transporter signature motif; other site 768492010295 Walker B; other site 768492010296 D-loop; other site 768492010297 H-loop/switch region; other site 768492010298 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768492010299 Walker A/P-loop; other site 768492010300 ATP binding site [chemical binding]; other site 768492010301 Q-loop/lid; other site 768492010302 ABC transporter signature motif; other site 768492010303 Walker B; other site 768492010304 D-loop; other site 768492010305 H-loop/switch region; other site 768492010306 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 768492010307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492010308 putative PBP binding loops; other site 768492010309 ABC-ATPase subunit interface; other site 768492010310 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 768492010311 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 768492010312 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492010313 dimer interface [polypeptide binding]; other site 768492010314 conserved gate region; other site 768492010315 putative PBP binding loops; other site 768492010316 ABC-ATPase subunit interface; other site 768492010317 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 768492010318 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 768492010319 alanine-tRNA ligase; Region: PLN02961 768492010320 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 768492010321 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492010322 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492010323 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492010324 putative effector binding pocket; other site 768492010325 dimerization interface [polypeptide binding]; other site 768492010326 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 768492010327 Predicted permeases [General function prediction only]; Region: RarD; COG2962 768492010328 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 768492010329 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 768492010330 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 768492010331 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 768492010332 catalytic core [active] 768492010333 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 768492010334 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 768492010335 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 768492010336 transmembrane helices; other site 768492010337 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 768492010338 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 768492010339 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 768492010340 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 768492010341 citrate lyase subunit gamma; Provisional; Region: PRK13253 768492010342 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 768492010343 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 768492010344 putative active site [active] 768492010345 (T/H)XGH motif; other site 768492010346 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 768492010347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492010348 active site 768492010349 phosphorylation site [posttranslational modification] 768492010350 intermolecular recognition site; other site 768492010351 dimerization interface [polypeptide binding]; other site 768492010352 Transcriptional regulator; Region: CitT; pfam12431 768492010353 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 768492010354 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 768492010355 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824 768492010356 putative hydrophobic ligand binding site [chemical binding]; other site 768492010357 acetoin reductases; Region: 23BDH; TIGR02415 768492010358 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492010359 NAD(P) binding site [chemical binding]; other site 768492010360 active site 768492010361 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 768492010362 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 768492010363 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768492010364 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768492010365 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768492010366 E3 interaction surface; other site 768492010367 lipoyl attachment site [posttranslational modification]; other site 768492010368 dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843 768492010369 e3 binding domain; Region: E3_binding; pfam02817 768492010370 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 768492010371 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 768492010372 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 768492010373 alpha subunit interface [polypeptide binding]; other site 768492010374 TPP binding site [chemical binding]; other site 768492010375 heterodimer interface [polypeptide binding]; other site 768492010376 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768492010377 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 768492010378 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 768492010379 tetramer interface [polypeptide binding]; other site 768492010380 TPP-binding site [chemical binding]; other site 768492010381 heterodimer interface [polypeptide binding]; other site 768492010382 phosphorylation loop region [posttranslational modification] 768492010383 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 768492010384 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 768492010385 Walker A motif; other site 768492010386 ATP binding site [chemical binding]; other site 768492010387 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492010388 DNA binding residues [nucleotide binding] 768492010389 dimerization interface [polypeptide binding]; other site 768492010390 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 768492010391 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 768492010392 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 768492010393 dimer interface [polypeptide binding]; other site 768492010394 active site 768492010395 heme binding site [chemical binding]; other site 768492010396 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 768492010397 HipA N-terminal domain; Region: Couple_hipA; pfam13657 768492010398 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 768492010399 HipA-like N-terminal domain; Region: HipA_N; pfam07805 768492010400 HipA-like C-terminal domain; Region: HipA_C; pfam07804 768492010401 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768492010402 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492010403 non-specific DNA binding site [nucleotide binding]; other site 768492010404 salt bridge; other site 768492010405 sequence-specific DNA binding site [nucleotide binding]; other site 768492010406 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 768492010407 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768492010408 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492010409 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 768492010410 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492010411 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492010412 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 768492010413 putative effector binding pocket; other site 768492010414 putative dimerization interface [polypeptide binding]; other site 768492010415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492010416 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768492010417 putative substrate translocation pore; other site 768492010418 putative arabinose transporter; Provisional; Region: PRK03545 768492010419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492010420 putative substrate translocation pore; other site 768492010421 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 768492010422 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 768492010423 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 768492010424 Walker A/P-loop; other site 768492010425 ATP binding site [chemical binding]; other site 768492010426 Q-loop/lid; other site 768492010427 ABC transporter signature motif; other site 768492010428 Walker B; other site 768492010429 D-loop; other site 768492010430 H-loop/switch region; other site 768492010431 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 768492010432 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 768492010433 Walker A/P-loop; other site 768492010434 ATP binding site [chemical binding]; other site 768492010435 Q-loop/lid; other site 768492010436 ABC transporter signature motif; other site 768492010437 Walker B; other site 768492010438 D-loop; other site 768492010439 H-loop/switch region; other site 768492010440 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 768492010441 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 768492010442 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 768492010443 TM-ABC transporter signature motif; other site 768492010444 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768492010445 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 768492010446 TM-ABC transporter signature motif; other site 768492010447 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 768492010448 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 768492010449 dimerization interface [polypeptide binding]; other site 768492010450 ligand binding site [chemical binding]; other site 768492010451 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492010452 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492010453 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 768492010454 putative effector binding pocket; other site 768492010455 putative dimerization interface [polypeptide binding]; other site 768492010456 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 768492010457 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768492010458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492010459 putative substrate translocation pore; other site 768492010460 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492010461 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492010462 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492010463 putative effector binding pocket; other site 768492010464 dimerization interface [polypeptide binding]; other site 768492010465 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 768492010466 active sites [active] 768492010467 tetramer interface [polypeptide binding]; other site 768492010468 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 768492010469 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 768492010470 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492010471 dimer interface [polypeptide binding]; other site 768492010472 conserved gate region; other site 768492010473 ABC-ATPase subunit interface; other site 768492010474 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 768492010475 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768492010476 Walker A/P-loop; other site 768492010477 ATP binding site [chemical binding]; other site 768492010478 Q-loop/lid; other site 768492010479 ABC transporter signature motif; other site 768492010480 Walker B; other site 768492010481 D-loop; other site 768492010482 H-loop/switch region; other site 768492010483 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492010484 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768492010485 putative substrate translocation pore; other site 768492010486 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 768492010487 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 768492010488 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768492010489 HlyD family secretion protein; Region: HlyD_3; pfam13437 768492010490 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492010491 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768492010492 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 768492010493 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 768492010494 Predicted transcriptional regulators [Transcription]; Region: COG1733 768492010495 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 768492010496 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 768492010497 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 768492010498 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 768492010499 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492010500 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492010501 dimerization interface [polypeptide binding]; other site 768492010502 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 768492010503 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 768492010504 metal binding site [ion binding]; metal-binding site 768492010505 putative dimer interface [polypeptide binding]; other site 768492010506 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 768492010507 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492010508 substrate binding pocket [chemical binding]; other site 768492010509 membrane-bound complex binding site; other site 768492010510 hinge residues; other site 768492010511 hypothetical protein; Provisional; Region: PRK05423 768492010512 Predicted membrane protein [Function unknown]; Region: COG1289 768492010513 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 768492010514 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 768492010515 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 768492010516 amidase catalytic site [active] 768492010517 Zn binding residues [ion binding]; other site 768492010518 substrate binding site [chemical binding]; other site 768492010519 Predicted transcriptional regulator [Transcription]; Region: COG2932 768492010520 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 768492010521 Catalytic site [active] 768492010522 Male sterility protein; Region: NAD_binding_4; pfam07993 768492010523 NAD(P) binding site [chemical binding]; other site 768492010524 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 768492010525 active site 768492010526 DNA polymerase III, theta subunit; Region: DNA_pol3_theta; cl11635 768492010527 exonuclease I; Provisional; Region: sbcB; PRK11779 768492010528 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 768492010529 active site 768492010530 catalytic site [active] 768492010531 substrate binding site [chemical binding]; other site 768492010532 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 768492010533 amino acid transporter; Region: 2A0306; TIGR00909 768492010534 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 768492010535 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 768492010536 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 768492010537 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492010538 non-specific DNA binding site [nucleotide binding]; other site 768492010539 salt bridge; other site 768492010540 sequence-specific DNA binding site [nucleotide binding]; other site 768492010541 Cupin domain; Region: Cupin_2; pfam07883 768492010542 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 768492010543 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 768492010544 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 768492010545 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768492010546 Walker A/P-loop; other site 768492010547 ATP binding site [chemical binding]; other site 768492010548 Q-loop/lid; other site 768492010549 ABC transporter signature motif; other site 768492010550 Walker B; other site 768492010551 D-loop; other site 768492010552 H-loop/switch region; other site 768492010553 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768492010554 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768492010555 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768492010556 TM-ABC transporter signature motif; other site 768492010557 putative outer membrane receptor; Provisional; Region: PRK13513 768492010558 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768492010559 N-terminal plug; other site 768492010560 ligand-binding site [chemical binding]; other site 768492010561 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 768492010562 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768492010563 Walker A/P-loop; other site 768492010564 ATP binding site [chemical binding]; other site 768492010565 Q-loop/lid; other site 768492010566 ABC transporter signature motif; other site 768492010567 Walker B; other site 768492010568 D-loop; other site 768492010569 H-loop/switch region; other site 768492010570 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 768492010571 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 768492010572 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768492010573 ABC-ATPase subunit interface; other site 768492010574 dimer interface [polypeptide binding]; other site 768492010575 putative PBP binding regions; other site 768492010576 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768492010577 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768492010578 metal binding site [ion binding]; metal-binding site 768492010579 active site 768492010580 I-site; other site 768492010581 lysine transporter; Provisional; Region: PRK10836 768492010582 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 768492010583 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492010584 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 768492010585 putative dimerization interface [polypeptide binding]; other site 768492010586 Predicted membrane protein [Function unknown]; Region: COG2855 768492010587 endonuclease IV; Provisional; Region: PRK01060 768492010588 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 768492010589 AP (apurinic/apyrimidinic) site pocket; other site 768492010590 DNA interaction; other site 768492010591 Metal-binding active site; metal-binding site 768492010592 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 768492010593 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 768492010594 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 768492010595 active site 768492010596 P-loop; other site 768492010597 phosphorylation site [posttranslational modification] 768492010598 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 768492010599 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 768492010600 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 768492010601 putative substrate binding site [chemical binding]; other site 768492010602 putative ATP binding site [chemical binding]; other site 768492010603 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 768492010604 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 768492010605 active site 768492010606 phosphorylation site [posttranslational modification] 768492010607 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 768492010608 dimerization domain swap beta strand [polypeptide binding]; other site 768492010609 regulatory protein interface [polypeptide binding]; other site 768492010610 active site 768492010611 regulatory phosphorylation site [posttranslational modification]; other site 768492010612 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_19; cd04678 768492010613 nudix motif; other site 768492010614 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 768492010615 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 768492010616 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 768492010617 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 768492010618 molybdopterin cofactor binding site [chemical binding]; other site 768492010619 substrate binding site [chemical binding]; other site 768492010620 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 768492010621 molybdopterin cofactor binding site; other site 768492010622 sugar efflux transporter B; Provisional; Region: PRK15011 768492010623 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492010624 putative substrate translocation pore; other site 768492010625 Flagellin N-methylase; Region: FliB; cl00497 768492010626 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 768492010627 aromatic amino acid transport protein; Region: araaP; TIGR00837 768492010628 elongation factor P; Provisional; Region: PRK04542 768492010629 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 768492010630 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 768492010631 RNA binding site [nucleotide binding]; other site 768492010632 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 768492010633 RNA binding site [nucleotide binding]; other site 768492010634 mannonate dehydratase; Provisional; Region: PRK03906 768492010635 mannonate dehydratase; Region: uxuA; TIGR00695 768492010636 D-mannonate oxidoreductase; Provisional; Region: PRK15037 768492010637 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 768492010638 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 768492010639 Fimbrial protein; Region: Fimbrial; cl01416 768492010640 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 768492010641 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 768492010642 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 768492010643 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 768492010644 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 768492010645 active site 768492010646 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 768492010647 NlpC/P60 family; Region: NLPC_P60; pfam00877 768492010648 phage resistance protein; Provisional; Region: PRK10551 768492010649 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 768492010650 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768492010651 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 768492010652 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 768492010653 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 768492010654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492010655 dimer interface [polypeptide binding]; other site 768492010656 conserved gate region; other site 768492010657 putative PBP binding loops; other site 768492010658 ABC-ATPase subunit interface; other site 768492010659 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 768492010660 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 768492010661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492010662 dimer interface [polypeptide binding]; other site 768492010663 conserved gate region; other site 768492010664 putative PBP binding loops; other site 768492010665 ABC-ATPase subunit interface; other site 768492010666 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 768492010667 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768492010668 Walker A/P-loop; other site 768492010669 ATP binding site [chemical binding]; other site 768492010670 Q-loop/lid; other site 768492010671 ABC transporter signature motif; other site 768492010672 Walker B; other site 768492010673 D-loop; other site 768492010674 H-loop/switch region; other site 768492010675 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768492010676 Walker A/P-loop; other site 768492010677 ATP binding site [chemical binding]; other site 768492010678 Q-loop/lid; other site 768492010679 ABC transporter signature motif; other site 768492010680 Walker B; other site 768492010681 D-loop; other site 768492010682 H-loop/switch region; other site 768492010683 hypothetical protein; Provisional; Region: PRK11835 768492010684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492010685 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 768492010686 putative substrate translocation pore; other site 768492010687 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 768492010688 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768492010689 RNA binding surface [nucleotide binding]; other site 768492010690 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 768492010691 active site 768492010692 uracil binding [chemical binding]; other site 768492010693 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 768492010694 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768492010695 ATP binding site [chemical binding]; other site 768492010696 putative Mg++ binding site [ion binding]; other site 768492010697 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768492010698 nucleotide binding region [chemical binding]; other site 768492010699 ATP-binding site [chemical binding]; other site 768492010700 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 768492010701 5S rRNA interface [nucleotide binding]; other site 768492010702 CTC domain interface [polypeptide binding]; other site 768492010703 L16 interface [polypeptide binding]; other site 768492010704 Nucleoid-associated protein [General function prediction only]; Region: COG3081 768492010705 nucleoid-associated protein NdpA; Validated; Region: PRK00378 768492010706 hypothetical protein; Provisional; Region: PRK13689 768492010707 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 768492010708 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 768492010709 Sulfatase; Region: Sulfatase; cl17466 768492010710 DinI-like family; Region: DinI; cl11630 768492010711 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 768492010712 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 768492010713 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 768492010714 active site 768492010715 oxyanion hole [active] 768492010716 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 768492010717 Phage-related protein, tail component [Function unknown]; Region: COG4733 768492010718 Putative phage tail protein; Region: Phage-tail_3; pfam13550 768492010719 Fibronectin type 3 domain; Region: FN3; smart00060 768492010720 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 768492010721 Fibronectin type III protein; Region: DUF3672; pfam12421 768492010722 Phage-related protein, tail component [Function unknown]; Region: COG4723 768492010723 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 768492010724 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 768492010725 MPN+ (JAMM) motif; other site 768492010726 Zinc-binding site [ion binding]; other site 768492010727 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 768492010728 NlpC/P60 family; Region: NLPC_P60; cl17555 768492010729 Phage-related protein [Function unknown]; Region: gp18; COG4672 768492010730 Phage minor tail protein; Region: Phage_min_tail; pfam05939 768492010731 Phage-related minor tail protein [Function unknown]; Region: COG5281 768492010732 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 768492010733 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 768492010734 Minor tail protein T; Region: Phage_tail_T; cl05636 768492010735 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; cl06106 768492010736 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 768492010737 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 768492010738 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 768492010739 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 768492010740 Uncharacterized conserved protein (DUF2190); Region: DUF2190; cl02289 768492010741 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 768492010742 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 768492010743 oligomer interface [polypeptide binding]; other site 768492010744 active site residues [active] 768492010745 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 768492010746 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 768492010747 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 768492010748 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 768492010749 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 768492010750 Protein of unknown function (DUF2560); Region: DUF2560; cl10280 768492010751 DNA polymerase III, theta subunit; Region: DNA_pol3_theta; pfam06440 768492010752 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 768492010753 Protein of unknown function (DUF754); Region: DUF754; pfam05449 768492010754 Antitermination protein; Region: Antiterm; pfam03589 768492010755 Antitermination protein; Region: Antiterm; pfam03589 768492010756 Protein of unknown function (DUF968); Region: DUF968; pfam06147 768492010757 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 768492010758 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 768492010759 cofactor binding site; other site 768492010760 DNA binding site [nucleotide binding] 768492010761 substrate interaction site [chemical binding]; other site 768492010762 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 768492010763 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 768492010764 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 768492010765 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 768492010766 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 768492010767 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 768492010768 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492010769 non-specific DNA binding site [nucleotide binding]; other site 768492010770 salt bridge; other site 768492010771 sequence-specific DNA binding site [nucleotide binding]; other site 768492010772 tellurite resistance protein terB; Region: terB; cd07176 768492010773 putative metal binding site [ion binding]; other site 768492010774 Uncharacterized conserved protein (DUF2303); Region: DUF2303; pfam10065 768492010775 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 768492010776 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 768492010777 DNA-binding interface [nucleotide binding]; DNA binding site 768492010778 Protein of unknown function (DUF551); Region: DUF551; pfam04448 768492010779 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 768492010780 active site 768492010781 catalytic site [active] 768492010782 substrate binding site [chemical binding]; other site 768492010783 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 768492010784 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768492010785 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768492010786 active site 768492010787 DNA binding site [nucleotide binding] 768492010788 Int/Topo IB signature motif; other site 768492010789 Acyltransferase family; Region: Acyl_transf_3; pfam01757 768492010790 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 768492010791 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 768492010792 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 768492010793 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 768492010794 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 768492010795 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 768492010796 SnoaL-like domain; Region: SnoaL_2; pfam12680 768492010797 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492010798 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768492010799 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768492010800 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 768492010801 putative metal binding site [ion binding]; other site 768492010802 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 768492010803 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 768492010804 trimer interface [polypeptide binding]; other site 768492010805 eyelet of channel; other site 768492010806 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492010807 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768492010808 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 768492010809 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492010810 ATP binding site [chemical binding]; other site 768492010811 Mg2+ binding site [ion binding]; other site 768492010812 G-X-G motif; other site 768492010813 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 768492010814 putative binding surface; other site 768492010815 active site 768492010816 transcriptional regulator RcsB; Provisional; Region: PRK10840 768492010817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492010818 active site 768492010819 phosphorylation site [posttranslational modification] 768492010820 intermolecular recognition site; other site 768492010821 dimerization interface [polypeptide binding]; other site 768492010822 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492010823 DNA binding residues [nucleotide binding] 768492010824 dimerization interface [polypeptide binding]; other site 768492010825 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 768492010826 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492010827 dimer interface [polypeptide binding]; other site 768492010828 phosphorylation site [posttranslational modification] 768492010829 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492010830 ATP binding site [chemical binding]; other site 768492010831 Mg2+ binding site [ion binding]; other site 768492010832 G-X-G motif; other site 768492010833 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 768492010834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492010835 active site 768492010836 phosphorylation site [posttranslational modification] 768492010837 intermolecular recognition site; other site 768492010838 dimerization interface [polypeptide binding]; other site 768492010839 DNA gyrase subunit A; Validated; Region: PRK05560 768492010840 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 768492010841 CAP-like domain; other site 768492010842 active site 768492010843 primary dimer interface [polypeptide binding]; other site 768492010844 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768492010845 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768492010846 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768492010847 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768492010848 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768492010849 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768492010850 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 768492010851 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492010852 S-adenosylmethionine binding site [chemical binding]; other site 768492010853 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 768492010854 ATP cone domain; Region: ATP-cone; pfam03477 768492010855 Class I ribonucleotide reductase; Region: RNR_I; cd01679 768492010856 active site 768492010857 dimer interface [polypeptide binding]; other site 768492010858 catalytic residues [active] 768492010859 effector binding site; other site 768492010860 R2 peptide binding site; other site 768492010861 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 768492010862 dimer interface [polypeptide binding]; other site 768492010863 putative radical transfer pathway; other site 768492010864 diiron center [ion binding]; other site 768492010865 tyrosyl radical; other site 768492010866 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768492010867 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 768492010868 catalytic loop [active] 768492010869 iron binding site [ion binding]; other site 768492010870 Hok/gef family; Region: HOK_GEF; cl11494 768492010871 hypothetical protein; Provisional; Region: PRK03673 768492010872 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 768492010873 putative MPT binding site; other site 768492010874 tyrosine transporter TyrP; Provisional; Region: PRK15132 768492010875 aromatic amino acid transport protein; Region: araaP; TIGR00837 768492010876 YfaZ precursor; Region: YfaZ; pfam07437 768492010877 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 768492010878 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 768492010879 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 768492010880 tetramer interface [polypeptide binding]; other site 768492010881 heme binding pocket [chemical binding]; other site 768492010882 NADPH binding site [chemical binding]; other site 768492010883 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 768492010884 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 768492010885 acyl-activating enzyme (AAE) consensus motif; other site 768492010886 putative AMP binding site [chemical binding]; other site 768492010887 putative active site [active] 768492010888 putative CoA binding site [chemical binding]; other site 768492010889 O-succinylbenzoate synthase; Provisional; Region: PRK05105 768492010890 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 768492010891 active site 768492010892 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768492010893 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 768492010894 substrate binding site [chemical binding]; other site 768492010895 oxyanion hole (OAH) forming residues; other site 768492010896 trimer interface [polypeptide binding]; other site 768492010897 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 768492010898 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 768492010899 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 768492010900 dimer interface [polypeptide binding]; other site 768492010901 tetramer interface [polypeptide binding]; other site 768492010902 PYR/PP interface [polypeptide binding]; other site 768492010903 TPP binding site [chemical binding]; other site 768492010904 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 768492010905 TPP-binding site; other site 768492010906 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 768492010907 chorismate binding enzyme; Region: Chorismate_bind; cl10555 768492010908 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 768492010909 Putative glucoamylase; Region: Glycoamylase; pfam10091 768492010910 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 768492010911 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 768492010912 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 768492010913 hypothetical protein; Provisional; Region: PRK10404 768492010914 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 768492010915 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 768492010916 putative NAD(P) binding site [chemical binding]; other site 768492010917 catalytic Zn binding site [ion binding]; other site 768492010918 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 768492010919 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 768492010920 NADP binding site [chemical binding]; other site 768492010921 homodimer interface [polypeptide binding]; other site 768492010922 active site 768492010923 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 768492010924 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492010925 DNA binding site [nucleotide binding] 768492010926 domain linker motif; other site 768492010927 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 768492010928 putative ligand binding site [chemical binding]; other site 768492010929 putative dimerization interface [polypeptide binding]; other site 768492010930 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 768492010931 Transmembrane secretion effector; Region: MFS_3; pfam05977 768492010932 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 768492010933 Cupin domain; Region: Cupin_2; cl17218 768492010934 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 768492010935 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768492010936 PYR/PP interface [polypeptide binding]; other site 768492010937 dimer interface [polypeptide binding]; other site 768492010938 TPP binding site [chemical binding]; other site 768492010939 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768492010940 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 768492010941 TPP-binding site [chemical binding]; other site 768492010942 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492010943 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492010944 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492010945 dimerization interface [polypeptide binding]; other site 768492010946 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 768492010947 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 768492010948 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 768492010949 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 768492010950 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 768492010951 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 768492010952 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 768492010953 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 768492010954 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 768492010955 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 768492010956 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 768492010957 4Fe-4S binding domain; Region: Fer4; pfam00037 768492010958 4Fe-4S binding domain; Region: Fer4; pfam00037 768492010959 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 768492010960 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 768492010961 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768492010962 catalytic loop [active] 768492010963 iron binding site [ion binding]; other site 768492010964 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 768492010965 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 768492010966 [4Fe-4S] binding site [ion binding]; other site 768492010967 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 768492010968 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 768492010969 SLBB domain; Region: SLBB; pfam10531 768492010970 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 768492010971 NADH dehydrogenase subunit E; Validated; Region: PRK07539 768492010972 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 768492010973 putative dimer interface [polypeptide binding]; other site 768492010974 [2Fe-2S] cluster binding site [ion binding]; other site 768492010975 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 768492010976 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 768492010977 NADH dehydrogenase subunit D; Validated; Region: PRK06075 768492010978 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 768492010979 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 768492010980 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 768492010981 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492010982 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 768492010983 putative dimerization interface [polypeptide binding]; other site 768492010984 aminotransferase AlaT; Validated; Region: PRK09265 768492010985 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492010986 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492010987 homodimer interface [polypeptide binding]; other site 768492010988 catalytic residue [active] 768492010989 5'-nucleotidase; Provisional; Region: PRK03826 768492010990 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 768492010991 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 768492010992 TrkA-C domain; Region: TrkA_C; pfam02080 768492010993 TrkA-C domain; Region: TrkA_C; pfam02080 768492010994 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 768492010995 putative phosphatase; Provisional; Region: PRK11587 768492010996 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492010997 motif II; other site 768492010998 hypothetical protein; Validated; Region: PRK05445 768492010999 hypothetical protein; Provisional; Region: PRK01816 768492011000 propionate/acetate kinase; Provisional; Region: PRK12379 768492011001 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 768492011002 phosphate acetyltransferase; Reviewed; Region: PRK05632 768492011003 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 768492011004 DRTGG domain; Region: DRTGG; pfam07085 768492011005 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 768492011006 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 768492011007 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 768492011008 nudix motif; other site 768492011009 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 768492011010 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 768492011011 active site 768492011012 metal binding site [ion binding]; metal-binding site 768492011013 homotetramer interface [polypeptide binding]; other site 768492011014 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 768492011015 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 768492011016 C-terminal domain interface [polypeptide binding]; other site 768492011017 GSH binding site (G-site) [chemical binding]; other site 768492011018 dimer interface [polypeptide binding]; other site 768492011019 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 768492011020 N-terminal domain interface [polypeptide binding]; other site 768492011021 putative dimer interface [polypeptide binding]; other site 768492011022 active site 768492011023 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 768492011024 homooctamer interface [polypeptide binding]; other site 768492011025 active site 768492011026 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 768492011027 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 768492011028 putative NAD(P) binding site [chemical binding]; other site 768492011029 putative active site [active] 768492011030 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 768492011031 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 768492011032 Walker A/P-loop; other site 768492011033 ATP binding site [chemical binding]; other site 768492011034 Q-loop/lid; other site 768492011035 ABC transporter signature motif; other site 768492011036 Walker B; other site 768492011037 D-loop; other site 768492011038 H-loop/switch region; other site 768492011039 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768492011040 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492011041 dimer interface [polypeptide binding]; other site 768492011042 conserved gate region; other site 768492011043 putative PBP binding loops; other site 768492011044 ABC-ATPase subunit interface; other site 768492011045 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768492011046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492011047 dimer interface [polypeptide binding]; other site 768492011048 conserved gate region; other site 768492011049 putative PBP binding loops; other site 768492011050 ABC-ATPase subunit interface; other site 768492011051 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492011052 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768492011053 substrate binding pocket [chemical binding]; other site 768492011054 membrane-bound complex binding site; other site 768492011055 hinge residues; other site 768492011056 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 768492011057 Flavoprotein; Region: Flavoprotein; pfam02441 768492011058 amidophosphoribosyltransferase; Provisional; Region: PRK09246 768492011059 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 768492011060 active site 768492011061 tetramer interface [polypeptide binding]; other site 768492011062 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768492011063 active site 768492011064 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 768492011065 colicin V production protein; Provisional; Region: PRK10845 768492011066 cell division protein DedD; Provisional; Region: PRK11633 768492011067 Sporulation related domain; Region: SPOR; pfam05036 768492011068 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 768492011069 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768492011070 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768492011071 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 768492011072 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 768492011073 hypothetical protein; Provisional; Region: PRK10847 768492011074 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 768492011075 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 768492011076 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 768492011077 dimerization interface 3.5A [polypeptide binding]; other site 768492011078 active site 768492011079 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 768492011080 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 768492011081 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 768492011082 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 768492011083 ligand binding site [chemical binding]; other site 768492011084 NAD binding site [chemical binding]; other site 768492011085 catalytic site [active] 768492011086 homodimer interface [polypeptide binding]; other site 768492011087 Cupin domain; Region: Cupin_2; cl17218 768492011088 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768492011089 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492011090 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492011091 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768492011092 EamA-like transporter family; Region: EamA; pfam00892 768492011093 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 768492011094 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768492011095 HAMP domain; Region: HAMP; pfam00672 768492011096 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492011097 dimer interface [polypeptide binding]; other site 768492011098 phosphorylation site [posttranslational modification] 768492011099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492011100 ATP binding site [chemical binding]; other site 768492011101 Mg2+ binding site [ion binding]; other site 768492011102 G-X-G motif; other site 768492011103 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 768492011104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492011105 active site 768492011106 phosphorylation site [posttranslational modification] 768492011107 intermolecular recognition site; other site 768492011108 dimerization interface [polypeptide binding]; other site 768492011109 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768492011110 DNA binding site [nucleotide binding] 768492011111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 768492011112 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 768492011113 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 768492011114 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 768492011115 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 768492011116 trimer interface [polypeptide binding]; other site 768492011117 active site 768492011118 CoA binding site [chemical binding]; other site 768492011119 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 768492011120 EamA-like transporter family; Region: EamA; pfam00892 768492011121 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768492011122 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492011123 DNA-binding site [nucleotide binding]; DNA binding site 768492011124 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492011125 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492011126 homodimer interface [polypeptide binding]; other site 768492011127 catalytic residue [active] 768492011128 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 768492011129 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 768492011130 catalytic residues [active] 768492011131 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 768492011132 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 768492011133 catalytic residues [active] 768492011134 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 768492011135 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 768492011136 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 768492011137 DsbD alpha interface [polypeptide binding]; other site 768492011138 catalytic residues [active] 768492011139 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 768492011140 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 768492011141 active site residue [active] 768492011142 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768492011143 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492011144 DNA-binding site [nucleotide binding]; DNA binding site 768492011145 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492011146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492011147 homodimer interface [polypeptide binding]; other site 768492011148 catalytic residue [active] 768492011149 putative transporter; Provisional; Region: PRK12382 768492011150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492011151 putative substrate translocation pore; other site 768492011152 putative catalytic site [active] 768492011153 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 768492011154 putative metal binding site [ion binding]; other site 768492011155 putative phosphate binding site [ion binding]; other site 768492011156 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 768492011157 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 768492011158 metal binding site [ion binding]; metal-binding site 768492011159 dimer interface [polypeptide binding]; other site 768492011160 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 768492011161 transmembrane helices; other site 768492011162 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 768492011163 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 768492011164 ApbE family; Region: ApbE; pfam02424 768492011165 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 768492011166 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 768492011167 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 768492011168 dimer interface [polypeptide binding]; other site 768492011169 active site 768492011170 Uncharacterized conserved protein [Function unknown]; Region: COG4121 768492011171 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 768492011172 YfcL protein; Region: YfcL; pfam08891 768492011173 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 768492011174 hypothetical protein; Provisional; Region: PRK10621 768492011175 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 768492011176 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 768492011177 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 768492011178 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 768492011179 Tetramer interface [polypeptide binding]; other site 768492011180 active site 768492011181 FMN-binding site [chemical binding]; other site 768492011182 HemK family putative methylases; Region: hemK_fam; TIGR00536 768492011183 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492011184 S-adenosylmethionine binding site [chemical binding]; other site 768492011185 hypothetical protein; Provisional; Region: PRK04946 768492011186 Smr domain; Region: Smr; pfam01713 768492011187 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768492011188 catalytic core [active] 768492011189 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 768492011190 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768492011191 substrate binding site [chemical binding]; other site 768492011192 oxyanion hole (OAH) forming residues; other site 768492011193 trimer interface [polypeptide binding]; other site 768492011194 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 768492011195 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768492011196 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768492011197 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 768492011198 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 768492011199 dimer interface [polypeptide binding]; other site 768492011200 active site 768492011201 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 768492011202 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 768492011203 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 768492011204 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 768492011205 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 768492011206 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768492011207 binding surface 768492011208 TPR motif; other site 768492011209 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 768492011210 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 768492011211 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 768492011212 catalytic residues [active] 768492011213 central insert; other site 768492011214 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 768492011215 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 768492011216 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 768492011217 heme exporter protein CcmC; Region: ccmC; TIGR01191 768492011218 heme exporter protein CcmB; Region: ccmB; TIGR01190 768492011219 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 768492011220 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 768492011221 Walker A/P-loop; other site 768492011222 ATP binding site [chemical binding]; other site 768492011223 Q-loop/lid; other site 768492011224 ABC transporter signature motif; other site 768492011225 Walker B; other site 768492011226 D-loop; other site 768492011227 H-loop/switch region; other site 768492011228 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 768492011229 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 768492011230 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492011231 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 768492011232 dimerization interface [polypeptide binding]; other site 768492011233 substrate binding pocket [chemical binding]; other site 768492011234 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768492011235 EamA-like transporter family; Region: EamA; pfam00892 768492011236 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 768492011237 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 768492011238 Transglycosylase SLT domain; Region: SLT_2; pfam13406 768492011239 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768492011240 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768492011241 catalytic residue [active] 768492011242 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 768492011243 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 768492011244 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 768492011245 aminotransferase; Validated; Region: PRK08175 768492011246 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492011247 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492011248 homodimer interface [polypeptide binding]; other site 768492011249 catalytic residue [active] 768492011250 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 768492011251 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768492011252 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 768492011253 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 768492011254 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 768492011255 GAF domain; Region: GAF; pfam01590 768492011256 Histidine kinase; Region: His_kinase; pfam06580 768492011257 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492011258 ATP binding site [chemical binding]; other site 768492011259 Mg2+ binding site [ion binding]; other site 768492011260 G-X-G motif; other site 768492011261 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 768492011262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492011263 active site 768492011264 phosphorylation site [posttranslational modification] 768492011265 intermolecular recognition site; other site 768492011266 dimerization interface [polypeptide binding]; other site 768492011267 LytTr DNA-binding domain; Region: LytTR; pfam04397 768492011268 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 768492011269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492011270 putative substrate translocation pore; other site 768492011271 glucokinase, proteobacterial type; Region: glk; TIGR00749 768492011272 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768492011273 nucleotide binding site [chemical binding]; other site 768492011274 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 768492011275 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 768492011276 Cl- selectivity filter; other site 768492011277 Cl- binding residues [ion binding]; other site 768492011278 pore gating glutamate residue; other site 768492011279 dimer interface [polypeptide binding]; other site 768492011280 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 768492011281 aspartate racemase; Region: asp_race; TIGR00035 768492011282 Predicted membrane protein [Function unknown]; Region: COG4125 768492011283 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 768492011284 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 768492011285 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492011286 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492011287 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768492011288 dimerization interface [polypeptide binding]; other site 768492011289 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 768492011290 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 768492011291 dimer interface [polypeptide binding]; other site 768492011292 PYR/PP interface [polypeptide binding]; other site 768492011293 TPP binding site [chemical binding]; other site 768492011294 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768492011295 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 768492011296 TPP-binding site [chemical binding]; other site 768492011297 dimer interface [polypeptide binding]; other site 768492011298 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768492011299 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768492011300 active site 768492011301 catalytic tetrad [active] 768492011302 manganese transport protein MntH; Reviewed; Region: PRK00701 768492011303 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 768492011304 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 768492011305 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 768492011306 Nucleoside recognition; Region: Gate; pfam07670 768492011307 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 768492011308 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 768492011309 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 768492011310 HIGH motif; other site 768492011311 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 768492011312 active site 768492011313 KMSKS motif; other site 768492011314 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 768492011315 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 768492011316 putative NAD(P) binding site [chemical binding]; other site 768492011317 active site 768492011318 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 768492011319 hydrophobic substrate binding pocket; other site 768492011320 Isochorismatase family; Region: Isochorismatase; pfam00857 768492011321 active site 768492011322 conserved cis-peptide bond; other site 768492011323 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 768492011324 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 768492011325 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 768492011326 acyl-activating enzyme (AAE) consensus motif; other site 768492011327 active site 768492011328 AMP binding site [chemical binding]; other site 768492011329 substrate binding site [chemical binding]; other site 768492011330 isochorismate synthase EntC; Provisional; Region: PRK15016 768492011331 chorismate binding enzyme; Region: Chorismate_bind; cl10555 768492011332 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 768492011333 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 768492011334 siderophore binding site; other site 768492011335 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492011336 H+ Antiporter protein; Region: 2A0121; TIGR00900 768492011337 putative substrate translocation pore; other site 768492011338 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 768492011339 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 768492011340 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768492011341 ABC-ATPase subunit interface; other site 768492011342 dimer interface [polypeptide binding]; other site 768492011343 putative PBP binding regions; other site 768492011344 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 768492011345 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768492011346 ABC-ATPase subunit interface; other site 768492011347 dimer interface [polypeptide binding]; other site 768492011348 putative PBP binding regions; other site 768492011349 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 768492011350 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768492011351 Walker A/P-loop; other site 768492011352 ATP binding site [chemical binding]; other site 768492011353 Q-loop/lid; other site 768492011354 ABC transporter signature motif; other site 768492011355 Walker B; other site 768492011356 D-loop; other site 768492011357 H-loop/switch region; other site 768492011358 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 768492011359 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 768492011360 acyl-activating enzyme (AAE) consensus motif; other site 768492011361 AMP binding site [chemical binding]; other site 768492011362 MbtH-like protein; Region: MbtH; cl01279 768492011363 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 768492011364 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 768492011365 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 768492011366 outer membrane receptor FepA; Provisional; Region: PRK13524 768492011367 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768492011368 N-terminal plug; other site 768492011369 ligand-binding site [chemical binding]; other site 768492011370 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 768492011371 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 768492011372 peptide binding site [polypeptide binding]; other site 768492011373 acetolactate synthase; Reviewed; Region: PRK08617 768492011374 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768492011375 PYR/PP interface [polypeptide binding]; other site 768492011376 dimer interface [polypeptide binding]; other site 768492011377 TPP binding site [chemical binding]; other site 768492011378 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768492011379 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 768492011380 TPP-binding site [chemical binding]; other site 768492011381 dimer interface [polypeptide binding]; other site 768492011382 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 768492011383 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492011384 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492011385 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492011386 putative effector binding pocket; other site 768492011387 dimerization interface [polypeptide binding]; other site 768492011388 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 768492011389 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 768492011390 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 768492011391 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 768492011392 FlxA-like protein; Region: FlxA; pfam14282 768492011393 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492011394 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492011395 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 768492011396 putative dimerization interface [polypeptide binding]; other site 768492011397 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 768492011398 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 768492011399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 768492011400 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 768492011401 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 768492011402 nucleotide binding pocket [chemical binding]; other site 768492011403 K-X-D-G motif; other site 768492011404 catalytic site [active] 768492011405 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 768492011406 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 768492011407 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 768492011408 Dimer interface [polypeptide binding]; other site 768492011409 BRCT sequence motif; other site 768492011410 cell division protein ZipA; Provisional; Region: PRK03427 768492011411 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 768492011412 FtsZ protein binding site [polypeptide binding]; other site 768492011413 putative sulfate transport protein CysZ; Validated; Region: PRK04949 768492011414 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 768492011415 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 768492011416 dimer interface [polypeptide binding]; other site 768492011417 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492011418 catalytic residue [active] 768492011419 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 768492011420 dimerization domain swap beta strand [polypeptide binding]; other site 768492011421 regulatory protein interface [polypeptide binding]; other site 768492011422 active site 768492011423 regulatory phosphorylation site [posttranslational modification]; other site 768492011424 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 768492011425 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 768492011426 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 768492011427 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 768492011428 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 768492011429 HPr interaction site; other site 768492011430 glycerol kinase (GK) interaction site [polypeptide binding]; other site 768492011431 active site 768492011432 phosphorylation site [posttranslational modification] 768492011433 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 768492011434 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768492011435 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768492011436 dimerization interface [polypeptide binding]; other site 768492011437 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492011438 dimer interface [polypeptide binding]; other site 768492011439 phosphorylation site [posttranslational modification] 768492011440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492011441 ATP binding site [chemical binding]; other site 768492011442 Mg2+ binding site [ion binding]; other site 768492011443 G-X-G motif; other site 768492011444 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768492011445 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492011446 active site 768492011447 phosphorylation site [posttranslational modification] 768492011448 intermolecular recognition site; other site 768492011449 dimerization interface [polypeptide binding]; other site 768492011450 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768492011451 DNA binding site [nucleotide binding] 768492011452 macrolide transporter subunit MacA; Provisional; Region: PRK11578 768492011453 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768492011454 HlyD family secretion protein; Region: HlyD_3; pfam13437 768492011455 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 768492011456 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768492011457 Walker A/P-loop; other site 768492011458 ATP binding site [chemical binding]; other site 768492011459 Q-loop/lid; other site 768492011460 ABC transporter signature motif; other site 768492011461 Walker B; other site 768492011462 D-loop; other site 768492011463 H-loop/switch region; other site 768492011464 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768492011465 FtsX-like permease family; Region: FtsX; pfam02687 768492011466 cysteine synthase B; Region: cysM; TIGR01138 768492011467 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 768492011468 dimer interface [polypeptide binding]; other site 768492011469 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492011470 catalytic residue [active] 768492011471 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 768492011472 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 768492011473 Walker A/P-loop; other site 768492011474 ATP binding site [chemical binding]; other site 768492011475 Q-loop/lid; other site 768492011476 ABC transporter signature motif; other site 768492011477 Walker B; other site 768492011478 D-loop; other site 768492011479 H-loop/switch region; other site 768492011480 TOBE-like domain; Region: TOBE_3; pfam12857 768492011481 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 768492011482 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492011483 dimer interface [polypeptide binding]; other site 768492011484 conserved gate region; other site 768492011485 putative PBP binding loops; other site 768492011486 ABC-ATPase subunit interface; other site 768492011487 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 768492011488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492011489 dimer interface [polypeptide binding]; other site 768492011490 conserved gate region; other site 768492011491 putative PBP binding loops; other site 768492011492 ABC-ATPase subunit interface; other site 768492011493 thiosulfate transporter subunit; Provisional; Region: PRK10852 768492011494 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 768492011495 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 768492011496 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 768492011497 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 768492011498 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 768492011499 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 768492011500 putative acetyltransferase; Provisional; Region: PRK03624 768492011501 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492011502 Coenzyme A binding pocket [chemical binding]; other site 768492011503 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 768492011504 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 768492011505 active site 768492011506 metal binding site [ion binding]; metal-binding site 768492011507 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 768492011508 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 768492011509 hypothetical protein; Validated; Region: PRK00124 768492011510 Protein of unknown function, DUF399; Region: DUF399; pfam04187 768492011511 S-methylmethionine transporter; Provisional; Region: PRK11387 768492011512 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 768492011513 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 768492011514 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 768492011515 Malic enzyme, N-terminal domain; Region: malic; pfam00390 768492011516 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 768492011517 putative NAD(P) binding site [chemical binding]; other site 768492011518 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 768492011519 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 768492011520 Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106 768492011521 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 768492011522 Glyco_18 domain; Region: Glyco_18; smart00636 768492011523 active site 768492011524 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 768492011525 transcriptional regulator, ArgP family; Region: argP; TIGR03298 768492011526 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492011527 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492011528 dimerization interface [polypeptide binding]; other site 768492011529 Chitin binding domain; Region: Chitin_bind_3; pfam03067 768492011530 transaldolase-like protein; Provisional; Region: PTZ00411 768492011531 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 768492011532 active site 768492011533 dimer interface [polypeptide binding]; other site 768492011534 catalytic residue [active] 768492011535 transketolase; Reviewed; Region: PRK12753 768492011536 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 768492011537 TPP-binding site [chemical binding]; other site 768492011538 dimer interface [polypeptide binding]; other site 768492011539 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 768492011540 PYR/PP interface [polypeptide binding]; other site 768492011541 dimer interface [polypeptide binding]; other site 768492011542 TPP binding site [chemical binding]; other site 768492011543 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768492011544 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 768492011545 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 768492011546 dimer interface [polypeptide binding]; other site 768492011547 ADP-ribose binding site [chemical binding]; other site 768492011548 active site 768492011549 nudix motif; other site 768492011550 metal binding site [ion binding]; metal-binding site 768492011551 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 768492011552 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 768492011553 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 768492011554 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 768492011555 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 768492011556 [4Fe-4S] binding site [ion binding]; other site 768492011557 molybdopterin cofactor binding site; other site 768492011558 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 768492011559 molybdopterin cofactor binding site; other site 768492011560 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 768492011561 ferredoxin-type protein NapF; Region: napF; TIGR00402 768492011562 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768492011563 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 768492011564 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 768492011565 HAMP domain; Region: HAMP; pfam00672 768492011566 dimerization interface [polypeptide binding]; other site 768492011567 Histidine kinase; Region: HisKA_3; pfam07730 768492011568 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492011569 ATP binding site [chemical binding]; other site 768492011570 Mg2+ binding site [ion binding]; other site 768492011571 G-X-G motif; other site 768492011572 transcriptional regulator NarP; Provisional; Region: PRK10403 768492011573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492011574 active site 768492011575 phosphorylation site [posttranslational modification] 768492011576 intermolecular recognition site; other site 768492011577 dimerization interface [polypeptide binding]; other site 768492011578 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492011579 DNA binding residues [nucleotide binding] 768492011580 dimerization interface [polypeptide binding]; other site 768492011581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4519 768492011582 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 768492011583 Protein export membrane protein; Region: SecD_SecF; cl14618 768492011584 putative outer membrane receptor; Provisional; Region: PRK13513 768492011585 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768492011586 N-terminal plug; other site 768492011587 ligand-binding site [chemical binding]; other site 768492011588 Uncharacterized conserved protein [Function unknown]; Region: COG3391 768492011589 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 768492011590 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768492011591 N-terminal plug; other site 768492011592 ligand-binding site [chemical binding]; other site 768492011593 Tetratrico peptide repeat; Region: TPR_5; pfam12688 768492011594 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768492011595 binding surface 768492011596 TPR motif; other site 768492011597 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492011598 Coenzyme A binding pocket [chemical binding]; other site 768492011599 Chorismate mutase type II; Region: CM_2; cl00693 768492011600 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768492011601 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 768492011602 ArsC family; Region: ArsC; pfam03960 768492011603 putative catalytic residues [active] 768492011604 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 768492011605 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 768492011606 metal binding site [ion binding]; metal-binding site 768492011607 dimer interface [polypeptide binding]; other site 768492011608 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 768492011609 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 768492011610 Uncharacterized protein family (UPF0370); Region: UPF0370; pfam13980 768492011611 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 768492011612 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 768492011613 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 768492011614 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 768492011615 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 768492011616 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 768492011617 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 768492011618 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 768492011619 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 768492011620 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 768492011621 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 768492011622 putative hydrolase; Provisional; Region: PRK11460 768492011623 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 768492011624 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 768492011625 Helicase; Region: Helicase_RecD; pfam05127 768492011626 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 768492011627 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 768492011628 Predicted metalloprotease [General function prediction only]; Region: COG2321 768492011629 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 768492011630 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 768492011631 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 768492011632 ATP binding site [chemical binding]; other site 768492011633 active site 768492011634 substrate binding site [chemical binding]; other site 768492011635 lipoprotein; Provisional; Region: PRK11679 768492011636 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 768492011637 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 768492011638 dihydrodipicolinate synthase; Region: dapA; TIGR00674 768492011639 dimer interface [polypeptide binding]; other site 768492011640 active site 768492011641 catalytic residue [active] 768492011642 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 768492011643 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 768492011644 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 768492011645 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 768492011646 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 768492011647 catalytic triad [active] 768492011648 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 768492011649 Domain of unknown function DUF20; Region: UPF0118; pfam01594 768492011650 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 768492011651 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 768492011652 MoaE homodimer interface [polypeptide binding]; other site 768492011653 MoaD interaction [polypeptide binding]; other site 768492011654 active site residues [active] 768492011655 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 768492011656 MoaE interaction surface [polypeptide binding]; other site 768492011657 MoeB interaction surface [polypeptide binding]; other site 768492011658 thiocarboxylated glycine; other site 768492011659 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 768492011660 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768492011661 FeS/SAM binding site; other site 768492011662 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 768492011663 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 768492011664 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 768492011665 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 768492011666 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 768492011667 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 768492011668 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 768492011669 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 768492011670 putative molybdopterin cofactor binding site [chemical binding]; other site 768492011671 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 768492011672 putative molybdopterin cofactor binding site; other site 768492011673 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 768492011674 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768492011675 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768492011676 putative DNA binding site [nucleotide binding]; other site 768492011677 putative Zn2+ binding site [ion binding]; other site 768492011678 AsnC family; Region: AsnC_trans_reg; pfam01037 768492011679 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 768492011680 Predicted transcriptional regulator [Transcription]; Region: COG1959 768492011681 Transcriptional regulator; Region: Rrf2; pfam02082 768492011682 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 768492011683 Peptidase family M48; Region: Peptidase_M48; pfam01435 768492011684 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 768492011685 ArsC family; Region: ArsC; pfam03960 768492011686 catalytic residues [active] 768492011687 DNA replication initiation factor; Provisional; Region: PRK08084 768492011688 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 768492011689 hypothetical protein; Provisional; Region: PRK10457 768492011690 uracil transporter; Provisional; Region: PRK10720 768492011691 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768492011692 active site 768492011693 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 768492011694 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 768492011695 dimerization interface [polypeptide binding]; other site 768492011696 putative ATP binding site [chemical binding]; other site 768492011697 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 768492011698 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 768492011699 active site 768492011700 substrate binding site [chemical binding]; other site 768492011701 cosubstrate binding site; other site 768492011702 catalytic site [active] 768492011703 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 768492011704 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 768492011705 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492011706 Coenzyme A binding pocket [chemical binding]; other site 768492011707 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3792 768492011708 haemagglutination activity domain; Region: Haemagg_act; pfam05860 768492011709 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 768492011710 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 768492011711 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 768492011712 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 768492011713 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 768492011714 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 768492011715 Walker A/P-loop; other site 768492011716 ATP binding site [chemical binding]; other site 768492011717 Q-loop/lid; other site 768492011718 ABC transporter signature motif; other site 768492011719 Walker B; other site 768492011720 D-loop; other site 768492011721 H-loop/switch region; other site 768492011722 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 768492011723 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 768492011724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492011725 dimer interface [polypeptide binding]; other site 768492011726 conserved gate region; other site 768492011727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 768492011728 ABC-ATPase subunit interface; other site 768492011729 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 768492011730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492011731 conserved gate region; other site 768492011732 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492011733 conserved gate region; other site 768492011734 putative PBP binding loops; other site 768492011735 ABC-ATPase subunit interface; other site 768492011736 polyphosphate kinase; Provisional; Region: PRK05443 768492011737 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 768492011738 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 768492011739 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 768492011740 domain interface [polypeptide binding]; other site 768492011741 active site 768492011742 catalytic site [active] 768492011743 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 768492011744 domain interface [polypeptide binding]; other site 768492011745 active site 768492011746 catalytic site [active] 768492011747 exopolyphosphatase; Provisional; Region: PRK10854 768492011748 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 768492011749 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 768492011750 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 768492011751 MgtE intracellular N domain; Region: MgtE_N; smart00924 768492011752 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 768492011753 Divalent cation transporter; Region: MgtE; pfam01769 768492011754 putative diguanylate cyclase; Provisional; Region: PRK09776 768492011755 MASE1; Region: MASE1; cl17823 768492011756 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768492011757 putative active site [active] 768492011758 heme pocket [chemical binding]; other site 768492011759 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768492011760 putative active site [active] 768492011761 heme pocket [chemical binding]; other site 768492011762 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768492011763 putative active site [active] 768492011764 heme pocket [chemical binding]; other site 768492011765 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768492011766 metal binding site [ion binding]; metal-binding site 768492011767 active site 768492011768 I-site; other site 768492011769 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768492011770 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 768492011771 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 768492011772 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 768492011773 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492011774 AlkA N-terminal domain; Region: AlkA_N; pfam06029 768492011775 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 768492011776 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 768492011777 minor groove reading motif; other site 768492011778 helix-hairpin-helix signature motif; other site 768492011779 substrate binding pocket [chemical binding]; other site 768492011780 active site 768492011781 putative chaperone; Provisional; Region: PRK11678 768492011782 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 768492011783 nucleotide binding site [chemical binding]; other site 768492011784 putative NEF/HSP70 interaction site [polypeptide binding]; other site 768492011785 SBD interface [polypeptide binding]; other site 768492011786 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768492011787 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768492011788 Predicted kinase [General function prediction only]; Region: COG0645 768492011789 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 768492011790 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768492011791 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768492011792 active site 768492011793 catalytic tetrad [active] 768492011794 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 768492011795 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768492011796 HlyD family secretion protein; Region: HlyD_3; pfam13437 768492011797 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 768492011798 Protein export membrane protein; Region: SecD_SecF; cl14618 768492011799 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 768492011800 putative transporter; Provisional; Region: PRK10504 768492011801 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492011802 putative substrate translocation pore; other site 768492011803 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 768492011804 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768492011805 dimerization interface [polypeptide binding]; other site 768492011806 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492011807 dimer interface [polypeptide binding]; other site 768492011808 phosphorylation site [posttranslational modification] 768492011809 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492011810 ATP binding site [chemical binding]; other site 768492011811 Mg2+ binding site [ion binding]; other site 768492011812 G-X-G motif; other site 768492011813 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 768492011814 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492011815 active site 768492011816 phosphorylation site [posttranslational modification] 768492011817 intermolecular recognition site; other site 768492011818 dimerization interface [polypeptide binding]; other site 768492011819 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768492011820 DNA binding site [nucleotide binding] 768492011821 Uncharacterized conserved protein [Function unknown]; Region: COG3422 768492011822 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 768492011823 putative protease; Provisional; Region: PRK15452 768492011824 Peptidase family U32; Region: Peptidase_U32; pfam01136 768492011825 lipid kinase; Reviewed; Region: PRK13054 768492011826 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 768492011827 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 768492011828 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 768492011829 putative active site pocket [active] 768492011830 putative metal binding site [ion binding]; other site 768492011831 putative oxidoreductase; Provisional; Region: PRK10083 768492011832 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 768492011833 putative NAD(P) binding site [chemical binding]; other site 768492011834 catalytic Zn binding site [ion binding]; other site 768492011835 structural Zn binding site [ion binding]; other site 768492011836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492011837 D-galactonate transporter; Region: 2A0114; TIGR00893 768492011838 putative substrate translocation pore; other site 768492011839 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 768492011840 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 768492011841 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 768492011842 Transcriptional regulators [Transcription]; Region: GntR; COG1802 768492011843 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492011844 DNA-binding site [nucleotide binding]; DNA binding site 768492011845 FCD domain; Region: FCD; pfam07729 768492011846 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 768492011847 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 768492011848 putative active site; other site 768492011849 catalytic residue [active] 768492011850 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 768492011851 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 768492011852 putative active site [active] 768492011853 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 768492011854 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816 768492011855 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 768492011856 dimer interface [polypeptide binding]; other site 768492011857 substrate binding site [chemical binding]; other site 768492011858 ATP binding site [chemical binding]; other site 768492011859 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 768492011860 substrate binding site [chemical binding]; other site 768492011861 multimerization interface [polypeptide binding]; other site 768492011862 ATP binding site [chemical binding]; other site 768492011863 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 768492011864 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492011865 Coenzyme A binding pocket [chemical binding]; other site 768492011866 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492011867 S-adenosylmethionine binding site [chemical binding]; other site 768492011868 Predicted transcriptional regulators [Transcription]; Region: COG1733 768492011869 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 768492011870 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 768492011871 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768492011872 RNA binding surface [nucleotide binding]; other site 768492011873 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 768492011874 probable active site [active] 768492011875 Autotransporter beta-domain; Region: Autotransporter; pfam03797 768492011876 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768492011877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492011878 active site 768492011879 phosphorylation site [posttranslational modification] 768492011880 intermolecular recognition site; other site 768492011881 dimerization interface [polypeptide binding]; other site 768492011882 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492011883 DNA binding residues [nucleotide binding] 768492011884 dimerization interface [polypeptide binding]; other site 768492011885 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768492011886 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492011887 dimer interface [polypeptide binding]; other site 768492011888 phosphorylation site [posttranslational modification] 768492011889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492011890 ATP binding site [chemical binding]; other site 768492011891 Mg2+ binding site [ion binding]; other site 768492011892 G-X-G motif; other site 768492011893 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492011894 Response regulator receiver domain; Region: Response_reg; pfam00072 768492011895 active site 768492011896 phosphorylation site [posttranslational modification] 768492011897 intermolecular recognition site; other site 768492011898 dimerization interface [polypeptide binding]; other site 768492011899 enoyl-CoA hydratase; Provisional; Region: PRK06688 768492011900 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768492011901 substrate binding site [chemical binding]; other site 768492011902 oxyanion hole (OAH) forming residues; other site 768492011903 trimer interface [polypeptide binding]; other site 768492011904 Predicted transcriptional regulators [Transcription]; Region: COG1733 768492011905 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 768492011906 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768492011907 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492011908 Coenzyme A binding pocket [chemical binding]; other site 768492011909 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768492011910 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768492011911 putative DNA binding site [nucleotide binding]; other site 768492011912 putative Zn2+ binding site [ion binding]; other site 768492011913 AsnC family; Region: AsnC_trans_reg; pfam01037 768492011914 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 768492011915 Bacterial sugar transferase; Region: Bac_transf; pfam02397 768492011916 Protein of unknown function (DUF342); Region: DUF342; pfam03961 768492011917 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 768492011918 GMP synthase; Reviewed; Region: guaA; PRK00074 768492011919 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 768492011920 AMP/PPi binding site [chemical binding]; other site 768492011921 candidate oxyanion hole; other site 768492011922 catalytic triad [active] 768492011923 potential glutamine specificity residues [chemical binding]; other site 768492011924 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 768492011925 ATP Binding subdomain [chemical binding]; other site 768492011926 Ligand Binding sites [chemical binding]; other site 768492011927 Dimerization subdomain; other site 768492011928 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 768492011929 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 768492011930 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 768492011931 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 768492011932 active site 768492011933 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 768492011934 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 768492011935 generic binding surface II; other site 768492011936 generic binding surface I; other site 768492011937 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 768492011938 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 768492011939 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 768492011940 putative active site [active] 768492011941 putative catalytic site [active] 768492011942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492011943 D-galactonate transporter; Region: 2A0114; TIGR00893 768492011944 putative substrate translocation pore; other site 768492011945 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768492011946 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492011947 DNA binding site [nucleotide binding] 768492011948 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 768492011949 ligand binding site [chemical binding]; other site 768492011950 dimerization interface [polypeptide binding]; other site 768492011951 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 768492011952 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 768492011953 active site 768492011954 Zn binding site [ion binding]; other site 768492011955 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 768492011956 Predicted permeases [General function prediction only]; Region: COG0679 768492011957 GTP-binding protein Der; Reviewed; Region: PRK00093 768492011958 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 768492011959 G1 box; other site 768492011960 GTP/Mg2+ binding site [chemical binding]; other site 768492011961 Switch I region; other site 768492011962 G2 box; other site 768492011963 Switch II region; other site 768492011964 G3 box; other site 768492011965 G4 box; other site 768492011966 G5 box; other site 768492011967 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 768492011968 G1 box; other site 768492011969 GTP/Mg2+ binding site [chemical binding]; other site 768492011970 Switch I region; other site 768492011971 G2 box; other site 768492011972 G3 box; other site 768492011973 Switch II region; other site 768492011974 G4 box; other site 768492011975 G5 box; other site 768492011976 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 768492011977 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 768492011978 Trp docking motif [polypeptide binding]; other site 768492011979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 768492011980 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 768492011981 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 768492011982 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 768492011983 dimer interface [polypeptide binding]; other site 768492011984 motif 1; other site 768492011985 active site 768492011986 motif 2; other site 768492011987 motif 3; other site 768492011988 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 768492011989 anticodon binding site; other site 768492011990 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 768492011991 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 768492011992 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 768492011993 cytoskeletal protein RodZ; Provisional; Region: PRK10856 768492011994 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492011995 non-specific DNA binding site [nucleotide binding]; other site 768492011996 salt bridge; other site 768492011997 sequence-specific DNA binding site [nucleotide binding]; other site 768492011998 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 768492011999 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 768492012000 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768492012001 binding surface 768492012002 TPR motif; other site 768492012003 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 768492012004 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768492012005 FeS/SAM binding site; other site 768492012006 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 768492012007 active site 768492012008 multimer interface [polypeptide binding]; other site 768492012009 penicillin-binding protein 1C; Provisional; Region: PRK11240 768492012010 Transglycosylase; Region: Transgly; pfam00912 768492012011 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 768492012012 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 768492012013 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 768492012014 MG2 domain; Region: A2M_N; pfam01835 768492012015 Alpha-2-macroglobulin family; Region: A2M; pfam00207 768492012016 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 768492012017 surface patch; other site 768492012018 thioester region; other site 768492012019 specificity defining residues; other site 768492012020 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 768492012021 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768492012022 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768492012023 active site turn [active] 768492012024 phosphorylation site [posttranslational modification] 768492012025 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 768492012026 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 768492012027 NAD binding site [chemical binding]; other site 768492012028 sugar binding site [chemical binding]; other site 768492012029 divalent metal binding site [ion binding]; other site 768492012030 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 768492012031 dimer interface [polypeptide binding]; other site 768492012032 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 768492012033 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768492012034 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768492012035 putative active site [active] 768492012036 SseB protein; Region: SseB; pfam07179 768492012037 aminopeptidase B; Provisional; Region: PRK05015 768492012038 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 768492012039 interface (dimer of trimers) [polypeptide binding]; other site 768492012040 Substrate-binding/catalytic site; other site 768492012041 Zn-binding sites [ion binding]; other site 768492012042 hypothetical protein; Provisional; Region: PRK10721 768492012043 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 768492012044 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768492012045 catalytic loop [active] 768492012046 iron binding site [ion binding]; other site 768492012047 chaperone protein HscA; Provisional; Region: hscA; PRK05183 768492012048 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 768492012049 nucleotide binding site [chemical binding]; other site 768492012050 putative NEF/HSP70 interaction site [polypeptide binding]; other site 768492012051 SBD interface [polypeptide binding]; other site 768492012052 co-chaperone HscB; Provisional; Region: hscB; PRK05014 768492012053 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 768492012054 HSP70 interaction site [polypeptide binding]; other site 768492012055 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 768492012056 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 768492012057 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 768492012058 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 768492012059 trimerization site [polypeptide binding]; other site 768492012060 active site 768492012061 cysteine desulfurase; Provisional; Region: PRK14012 768492012062 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 768492012063 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492012064 catalytic residue [active] 768492012065 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 768492012066 Rrf2 family protein; Region: rrf2_super; TIGR00738 768492012067 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 768492012068 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 768492012069 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 768492012070 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 768492012071 active site 768492012072 dimerization interface [polypeptide binding]; other site 768492012073 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 768492012074 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 768492012075 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 768492012076 PRD domain; Region: PRD; pfam00874 768492012077 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 768492012078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492012079 putative substrate translocation pore; other site 768492012080 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 768492012081 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 768492012082 dimer interface [polypeptide binding]; other site 768492012083 active site 768492012084 glycine-pyridoxal phosphate binding site [chemical binding]; other site 768492012085 folate binding site [chemical binding]; other site 768492012086 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 768492012087 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 768492012088 heme-binding site [chemical binding]; other site 768492012089 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 768492012090 FAD binding pocket [chemical binding]; other site 768492012091 FAD binding motif [chemical binding]; other site 768492012092 phosphate binding motif [ion binding]; other site 768492012093 beta-alpha-beta structure motif; other site 768492012094 NAD binding pocket [chemical binding]; other site 768492012095 Heme binding pocket [chemical binding]; other site 768492012096 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 768492012097 Nitrogen regulatory protein P-II; Region: P-II; smart00938 768492012098 NAD synthetase; Provisional; Region: PRK13981 768492012099 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 768492012100 multimer interface [polypeptide binding]; other site 768492012101 active site 768492012102 catalytic triad [active] 768492012103 protein interface 1 [polypeptide binding]; other site 768492012104 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 768492012105 homodimer interface [polypeptide binding]; other site 768492012106 NAD binding pocket [chemical binding]; other site 768492012107 ATP binding pocket [chemical binding]; other site 768492012108 Mg binding site [ion binding]; other site 768492012109 active-site loop [active] 768492012110 response regulator GlrR; Provisional; Region: PRK15115 768492012111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492012112 active site 768492012113 phosphorylation site [posttranslational modification] 768492012114 intermolecular recognition site; other site 768492012115 dimerization interface [polypeptide binding]; other site 768492012116 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492012117 Walker A motif; other site 768492012118 ATP binding site [chemical binding]; other site 768492012119 Walker B motif; other site 768492012120 arginine finger; other site 768492012121 hypothetical protein; Provisional; Region: PRK10722 768492012122 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768492012123 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492012124 dimer interface [polypeptide binding]; other site 768492012125 phosphorylation site [posttranslational modification] 768492012126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492012127 ATP binding site [chemical binding]; other site 768492012128 Mg2+ binding site [ion binding]; other site 768492012129 G-X-G motif; other site 768492012130 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 768492012131 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 768492012132 dimerization interface [polypeptide binding]; other site 768492012133 ATP binding site [chemical binding]; other site 768492012134 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 768492012135 dimerization interface [polypeptide binding]; other site 768492012136 ATP binding site [chemical binding]; other site 768492012137 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 768492012138 putative active site [active] 768492012139 catalytic triad [active] 768492012140 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 768492012141 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492012142 substrate binding pocket [chemical binding]; other site 768492012143 membrane-bound complex binding site; other site 768492012144 hinge residues; other site 768492012145 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768492012146 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768492012147 catalytic residue [active] 768492012148 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 768492012149 nucleoside/Zn binding site; other site 768492012150 dimer interface [polypeptide binding]; other site 768492012151 catalytic motif [active] 768492012152 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 768492012153 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768492012154 active site turn [active] 768492012155 phosphorylation site [posttranslational modification] 768492012156 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768492012157 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 768492012158 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 768492012159 putative active site [active] 768492012160 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768492012161 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 768492012162 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768492012163 putative active site [active] 768492012164 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 768492012165 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 768492012166 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 768492012167 active site 768492012168 hydrophilic channel; other site 768492012169 dimerization interface [polypeptide binding]; other site 768492012170 catalytic residues [active] 768492012171 active site lid [active] 768492012172 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 768492012173 Recombination protein O N terminal; Region: RecO_N; pfam11967 768492012174 Recombination protein O C terminal; Region: RecO_C; pfam02565 768492012175 GTPase Era; Reviewed; Region: era; PRK00089 768492012176 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 768492012177 G1 box; other site 768492012178 GTP/Mg2+ binding site [chemical binding]; other site 768492012179 Switch I region; other site 768492012180 G2 box; other site 768492012181 Switch II region; other site 768492012182 G3 box; other site 768492012183 G4 box; other site 768492012184 G5 box; other site 768492012185 KH domain; Region: KH_2; pfam07650 768492012186 ribonuclease III; Reviewed; Region: rnc; PRK00102 768492012187 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 768492012188 dimerization interface [polypeptide binding]; other site 768492012189 active site 768492012190 metal binding site [ion binding]; metal-binding site 768492012191 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 768492012192 dsRNA binding site [nucleotide binding]; other site 768492012193 signal peptidase I; Provisional; Region: PRK10861 768492012194 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 768492012195 Catalytic site [active] 768492012196 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 768492012197 GTP-binding protein LepA; Provisional; Region: PRK05433 768492012198 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 768492012199 G1 box; other site 768492012200 putative GEF interaction site [polypeptide binding]; other site 768492012201 GTP/Mg2+ binding site [chemical binding]; other site 768492012202 Switch I region; other site 768492012203 G2 box; other site 768492012204 G3 box; other site 768492012205 Switch II region; other site 768492012206 G4 box; other site 768492012207 G5 box; other site 768492012208 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 768492012209 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 768492012210 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 768492012211 SoxR reducing system protein RseC; Provisional; Region: PRK10862 768492012212 anti-sigma E factor; Provisional; Region: rseB; PRK09455 768492012213 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 768492012214 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 768492012215 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 768492012216 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 768492012217 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 768492012218 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768492012219 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768492012220 DNA binding residues [nucleotide binding] 768492012221 L-aspartate oxidase; Provisional; Region: PRK09077 768492012222 L-aspartate oxidase; Provisional; Region: PRK06175 768492012223 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 768492012224 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 768492012225 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492012226 S-adenosylmethionine binding site [chemical binding]; other site 768492012227 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 768492012228 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 768492012229 ATP binding site [chemical binding]; other site 768492012230 Mg++ binding site [ion binding]; other site 768492012231 motif III; other site 768492012232 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768492012233 nucleotide binding region [chemical binding]; other site 768492012234 ATP-binding site [chemical binding]; other site 768492012235 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 768492012236 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 768492012237 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 768492012238 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 768492012239 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 768492012240 ligand binding site [chemical binding]; other site 768492012241 active site 768492012242 UGI interface [polypeptide binding]; other site 768492012243 catalytic site [active] 768492012244 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 768492012245 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 768492012246 dimer interface [polypeptide binding]; other site 768492012247 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 768492012248 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 768492012249 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 768492012250 recombination and repair protein; Provisional; Region: PRK10869 768492012251 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 768492012252 Walker A/P-loop; other site 768492012253 ATP binding site [chemical binding]; other site 768492012254 Q-loop/lid; other site 768492012255 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 768492012256 ABC transporter signature motif; other site 768492012257 Walker B; other site 768492012258 D-loop; other site 768492012259 H-loop/switch region; other site 768492012260 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 768492012261 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 768492012262 hypothetical protein; Validated; Region: PRK01777 768492012263 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 768492012264 putative coenzyme Q binding site [chemical binding]; other site 768492012265 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 768492012266 SmpB-tmRNA interface; other site 768492012267 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492012268 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492012269 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492012270 dimerization interface [polypeptide binding]; other site 768492012271 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 768492012272 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 768492012273 potential catalytic triad [active] 768492012274 conserved cys residue [active] 768492012275 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768492012276 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768492012277 active site 768492012278 catalytic tetrad [active] 768492012279 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 768492012280 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 768492012281 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 768492012282 Uncharacterized conserved protein [Function unknown]; Region: COG1359 768492012283 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 768492012284 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 768492012285 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 768492012286 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 768492012287 putative NAD(P) binding site [chemical binding]; other site 768492012288 Predicted transcriptional regulator [Transcription]; Region: COG2378 768492012289 HTH domain; Region: HTH_11; pfam08279 768492012290 WYL domain; Region: WYL; cl14852 768492012291 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492012292 Coenzyme A binding pocket [chemical binding]; other site 768492012293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492012294 S-adenosylmethionine binding site [chemical binding]; other site 768492012295 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 768492012296 Predicted acetyltransferase [General function prediction only]; Region: COG2388 768492012297 Predicted membrane protein [Function unknown]; Region: COG2259 768492012298 MbeD/MobD like; Region: MbeD_MobD; pfam04899 768492012299 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 768492012300 hypothetical protein; Provisional; Region: PRK10556 768492012301 major facilitator superfamily transporter; Provisional; Region: PRK05122 768492012302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492012303 putative substrate translocation pore; other site 768492012304 Helix-turn-helix domain; Region: HTH_18; pfam12833 768492012305 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492012306 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 768492012307 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492012308 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492012309 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492012310 putative effector binding pocket; other site 768492012311 dimerization interface [polypeptide binding]; other site 768492012312 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492012313 putative substrate translocation pore; other site 768492012314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492012315 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 768492012316 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 768492012317 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768492012318 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492012319 DNA-binding site [nucleotide binding]; DNA binding site 768492012320 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492012321 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492012322 homodimer interface [polypeptide binding]; other site 768492012323 catalytic residue [active] 768492012324 Uncharacterized conserved protein [Function unknown]; Region: COG2128 768492012325 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 768492012326 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 768492012327 catalytic residues [active] 768492012328 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 768492012329 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 768492012330 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 768492012331 Class I ribonucleotide reductase; Region: RNR_I; cd01679 768492012332 active site 768492012333 dimer interface [polypeptide binding]; other site 768492012334 catalytic residues [active] 768492012335 effector binding site; other site 768492012336 R2 peptide binding site; other site 768492012337 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 768492012338 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 768492012339 dimer interface [polypeptide binding]; other site 768492012340 putative radical transfer pathway; other site 768492012341 diiron center [ion binding]; other site 768492012342 tyrosyl radical; other site 768492012343 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 768492012344 HicB family; Region: HicB; pfam05534 768492012345 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 768492012346 short chain dehydrogenase; Provisional; Region: PRK12937 768492012347 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 768492012348 NADP binding site [chemical binding]; other site 768492012349 homodimer interface [polypeptide binding]; other site 768492012350 active site 768492012351 substrate binding site [chemical binding]; other site 768492012352 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492012353 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492012354 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 768492012355 putative effector binding pocket; other site 768492012356 putative dimerization interface [polypeptide binding]; other site 768492012357 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 768492012358 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 768492012359 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 768492012360 active site 768492012361 nucleophile elbow; other site 768492012362 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 768492012363 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 768492012364 PAS domain; Region: PAS; smart00091 768492012365 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492012366 ATP binding site [chemical binding]; other site 768492012367 Mg2+ binding site [ion binding]; other site 768492012368 G-X-G motif; other site 768492012369 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 768492012370 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492012371 active site 768492012372 phosphorylation site [posttranslational modification] 768492012373 intermolecular recognition site; other site 768492012374 dimerization interface [polypeptide binding]; other site 768492012375 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 768492012376 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 768492012377 Walker A/P-loop; other site 768492012378 ATP binding site [chemical binding]; other site 768492012379 Q-loop/lid; other site 768492012380 ABC transporter signature motif; other site 768492012381 Walker B; other site 768492012382 D-loop; other site 768492012383 H-loop/switch region; other site 768492012384 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 768492012385 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 768492012386 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492012387 dimer interface [polypeptide binding]; other site 768492012388 conserved gate region; other site 768492012389 putative PBP binding loops; other site 768492012390 ABC-ATPase subunit interface; other site 768492012391 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 768492012392 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 768492012393 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 768492012394 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 768492012395 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492012396 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492012397 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 768492012398 putative dimerization interface [polypeptide binding]; other site 768492012399 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492012400 putative substrate translocation pore; other site 768492012401 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768492012402 transcriptional repressor MprA; Provisional; Region: PRK10870 768492012403 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768492012404 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 768492012405 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 768492012406 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768492012407 HlyD family secretion protein; Region: HlyD_3; pfam13437 768492012408 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 768492012409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492012410 putative substrate translocation pore; other site 768492012411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492012412 putative methyltransferase; Provisional; Region: PRK10864 768492012413 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 768492012414 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 768492012415 thioredoxin 2; Provisional; Region: PRK10996 768492012416 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 768492012417 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 768492012418 catalytic residues [active] 768492012419 Uncharacterized conserved protein [Function unknown]; Region: COG3148 768492012420 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 768492012421 CoA binding domain; Region: CoA_binding_2; pfam13380 768492012422 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 768492012423 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 768492012424 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768492012425 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492012426 Coenzyme A binding pocket [chemical binding]; other site 768492012427 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 768492012428 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 768492012429 domain interface [polypeptide binding]; other site 768492012430 putative active site [active] 768492012431 catalytic site [active] 768492012432 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 768492012433 domain interface [polypeptide binding]; other site 768492012434 putative active site [active] 768492012435 catalytic site [active] 768492012436 lipoprotein; Provisional; Region: PRK10759 768492012437 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 768492012438 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492012439 putative substrate translocation pore; other site 768492012440 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 768492012441 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492012442 active site 768492012443 motif I; other site 768492012444 motif II; other site 768492012445 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 768492012446 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 768492012447 Walker A/P-loop; other site 768492012448 ATP binding site [chemical binding]; other site 768492012449 Q-loop/lid; other site 768492012450 ABC transporter signature motif; other site 768492012451 Walker B; other site 768492012452 D-loop; other site 768492012453 H-loop/switch region; other site 768492012454 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 768492012455 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492012456 dimer interface [polypeptide binding]; other site 768492012457 conserved gate region; other site 768492012458 ABC-ATPase subunit interface; other site 768492012459 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 768492012460 lipoprotein, YaeC family; Region: TIGR00363 768492012461 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 768492012462 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 768492012463 homodimer interaction site [polypeptide binding]; other site 768492012464 cofactor binding site; other site 768492012465 prolyl-tRNA synthetase; Provisional; Region: PRK09194 768492012466 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 768492012467 dimer interface [polypeptide binding]; other site 768492012468 motif 1; other site 768492012469 active site 768492012470 motif 2; other site 768492012471 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 768492012472 putative deacylase active site [active] 768492012473 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 768492012474 active site 768492012475 motif 3; other site 768492012476 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 768492012477 anticodon binding site; other site 768492012478 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 768492012479 NlpE N-terminal domain; Region: NlpE; pfam04170 768492012480 hypothetical protein; Provisional; Region: PRK09256 768492012481 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 768492012482 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 768492012483 hypothetical protein; Provisional; Region: PRK04964 768492012484 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 768492012485 Cytochrome c; Region: Cytochrom_C; cl11414 768492012486 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 768492012487 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 768492012488 Ligand Binding Site [chemical binding]; other site 768492012489 TilS substrate binding domain; Region: TilS; pfam09179 768492012490 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 768492012491 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 768492012492 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768492012493 putative metal binding site [ion binding]; other site 768492012494 lysine decarboxylase LdcC; Provisional; Region: PRK15399 768492012495 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 768492012496 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 768492012497 homodimer interface [polypeptide binding]; other site 768492012498 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492012499 catalytic residue [active] 768492012500 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 768492012501 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 768492012502 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 768492012503 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 768492012504 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 768492012505 putative active site [active] 768492012506 putative PHP Thumb interface [polypeptide binding]; other site 768492012507 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 768492012508 generic binding surface II; other site 768492012509 generic binding surface I; other site 768492012510 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 768492012511 RNA/DNA hybrid binding site [nucleotide binding]; other site 768492012512 active site 768492012513 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 768492012514 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 768492012515 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 768492012516 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 768492012517 active site 768492012518 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 768492012519 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 768492012520 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 768492012521 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 768492012522 trimer interface [polypeptide binding]; other site 768492012523 active site 768492012524 UDP-GlcNAc binding site [chemical binding]; other site 768492012525 lipid binding site [chemical binding]; lipid-binding site 768492012526 periplasmic chaperone; Provisional; Region: PRK10780 768492012527 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 768492012528 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 768492012529 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768492012530 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768492012531 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768492012532 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768492012533 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768492012534 Surface antigen; Region: Bac_surface_Ag; pfam01103 768492012535 zinc metallopeptidase RseP; Provisional; Region: PRK10779 768492012536 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 768492012537 active site 768492012538 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 768492012539 protein binding site [polypeptide binding]; other site 768492012540 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 768492012541 protein binding site [polypeptide binding]; other site 768492012542 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 768492012543 putative substrate binding region [chemical binding]; other site 768492012544 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 768492012545 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 768492012546 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 768492012547 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 768492012548 catalytic residue [active] 768492012549 putative FPP diphosphate binding site; other site 768492012550 putative FPP binding hydrophobic cleft; other site 768492012551 dimer interface [polypeptide binding]; other site 768492012552 putative IPP diphosphate binding site; other site 768492012553 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 768492012554 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 768492012555 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 768492012556 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 768492012557 ribosome recycling factor; Reviewed; Region: frr; PRK00083 768492012558 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 768492012559 hinge region; other site 768492012560 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 768492012561 putative nucleotide binding site [chemical binding]; other site 768492012562 uridine monophosphate binding site [chemical binding]; other site 768492012563 homohexameric interface [polypeptide binding]; other site 768492012564 elongation factor Ts; Provisional; Region: tsf; PRK09377 768492012565 UBA/TS-N domain; Region: UBA; pfam00627 768492012566 Elongation factor TS; Region: EF_TS; pfam00889 768492012567 Elongation factor TS; Region: EF_TS; pfam00889 768492012568 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 768492012569 rRNA interaction site [nucleotide binding]; other site 768492012570 S8 interaction site; other site 768492012571 putative laminin-1 binding site; other site 768492012572 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 768492012573 active site 768492012574 PII uridylyl-transferase; Provisional; Region: PRK05007 768492012575 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 768492012576 metal binding triad; other site 768492012577 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 768492012578 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768492012579 Zn2+ binding site [ion binding]; other site 768492012580 Mg2+ binding site [ion binding]; other site 768492012581 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 768492012582 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 768492012583 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 768492012584 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 768492012585 trimer interface [polypeptide binding]; other site 768492012586 active site 768492012587 substrate binding site [chemical binding]; other site 768492012588 CoA binding site [chemical binding]; other site 768492012589 hypothetical protein; Provisional; Region: PRK13677 768492012590 flavodoxin; Provisional; Region: PRK08105 768492012591 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 768492012592 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 768492012593 probable active site [active] 768492012594 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 768492012595 benzoate transport; Region: 2A0115; TIGR00895 768492012596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492012597 putative substrate translocation pore; other site 768492012598 SecY interacting protein Syd; Provisional; Region: PRK04968 768492012599 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 768492012600 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 768492012601 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 768492012602 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 768492012603 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 768492012604 flap endonuclease-like protein; Provisional; Region: PRK09482 768492012605 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 768492012606 active site 768492012607 metal binding site 1 [ion binding]; metal-binding site 768492012608 putative 5' ssDNA interaction site; other site 768492012609 metal binding site 3; metal-binding site 768492012610 metal binding site 2 [ion binding]; metal-binding site 768492012611 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 768492012612 putative DNA binding site [nucleotide binding]; other site 768492012613 putative metal binding site [ion binding]; other site 768492012614 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 768492012615 FtsJ-like methyltransferase; Region: FtsJ; cl17430 768492012616 hypothetical protein; Provisional; Region: PRK10873 768492012617 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768492012618 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492012619 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 768492012620 dimerization interface [polypeptide binding]; other site 768492012621 substrate binding pocket [chemical binding]; other site 768492012622 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 768492012623 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 768492012624 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 768492012625 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492012626 catalytic residue [active] 768492012627 cysteine desulfurase, sulfur acceptor subunit CsdE; Region: FeS_syn_CsdE; TIGR03391 768492012628 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 768492012629 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 768492012630 putative ATP binding site [chemical binding]; other site 768492012631 putative substrate interface [chemical binding]; other site 768492012632 murein transglycosylase A; Provisional; Region: mltA; PRK11162 768492012633 MltA specific insert domain; Region: MltA; smart00925 768492012634 3D domain; Region: 3D; pfam06725 768492012635 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 768492012636 AMIN domain; Region: AMIN; pfam11741 768492012637 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 768492012638 active site 768492012639 metal binding site [ion binding]; metal-binding site 768492012640 N-acetylglutamate synthase; Validated; Region: PRK05279 768492012641 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 768492012642 putative feedback inhibition sensing region; other site 768492012643 putative nucleotide binding site [chemical binding]; other site 768492012644 putative substrate binding site [chemical binding]; other site 768492012645 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492012646 Coenzyme A binding pocket [chemical binding]; other site 768492012647 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 768492012648 AAA domain; Region: AAA_30; pfam13604 768492012649 Family description; Region: UvrD_C_2; pfam13538 768492012650 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 768492012651 protease3; Provisional; Region: PRK15101 768492012652 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 768492012653 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 768492012654 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 768492012655 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 768492012656 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 768492012657 hypothetical protein; Provisional; Region: PRK10332 768492012658 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 768492012659 Protein of unknown function (DUF2509); Region: DUF2509; cl11672 768492012660 hypothetical protein; Provisional; Region: PRK10557 768492012661 hypothetical protein; Provisional; Region: PRK10506 768492012662 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 768492012663 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 768492012664 thymidylate synthase; Reviewed; Region: thyA; PRK01827 768492012665 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 768492012666 dimerization interface [polypeptide binding]; other site 768492012667 active site 768492012668 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 768492012669 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 768492012670 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 768492012671 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 768492012672 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 768492012673 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 768492012674 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 768492012675 putative active site [active] 768492012676 Ap4A binding site [chemical binding]; other site 768492012677 nudix motif; other site 768492012678 putative metal binding site [ion binding]; other site 768492012679 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 768492012680 putative DNA-binding cleft [nucleotide binding]; other site 768492012681 putative DNA clevage site; other site 768492012682 molecular lever; other site 768492012683 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 768492012684 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 768492012685 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768492012686 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768492012687 active site 768492012688 catalytic tetrad [active] 768492012689 lysophospholipid transporter LplT; Provisional; Region: PRK11195 768492012690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492012691 putative substrate translocation pore; other site 768492012692 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 768492012693 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 768492012694 putative acyl-acceptor binding pocket; other site 768492012695 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 768492012696 acyl-activating enzyme (AAE) consensus motif; other site 768492012697 putative AMP binding site [chemical binding]; other site 768492012698 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 768492012699 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 768492012700 molybdopterin cofactor binding site [chemical binding]; other site 768492012701 substrate binding site [chemical binding]; other site 768492012702 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 768492012703 molybdopterin cofactor binding site; other site 768492012704 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 768492012705 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492012706 DNA binding site [nucleotide binding] 768492012707 domain linker motif; other site 768492012708 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 768492012709 dimerization interface (closed form) [polypeptide binding]; other site 768492012710 ligand binding site [chemical binding]; other site 768492012711 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492012712 Coenzyme A binding pocket [chemical binding]; other site 768492012713 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768492012714 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492012715 DNA binding site [nucleotide binding] 768492012716 domain linker motif; other site 768492012717 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 768492012718 dimerization interface (closed form) [polypeptide binding]; other site 768492012719 ligand binding site [chemical binding]; other site 768492012720 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492012721 sequence-specific DNA binding site [nucleotide binding]; other site 768492012722 salt bridge; other site 768492012723 diaminopimelate decarboxylase; Provisional; Region: PRK11165 768492012724 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 768492012725 active site 768492012726 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768492012727 substrate binding site [chemical binding]; other site 768492012728 catalytic residues [active] 768492012729 dimer interface [polypeptide binding]; other site 768492012730 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 768492012731 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492012732 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492012733 dimerization interface [polypeptide binding]; other site 768492012734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492012735 putative substrate translocation pore; other site 768492012736 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768492012737 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492012738 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492012739 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492012740 putative effector binding pocket; other site 768492012741 dimerization interface [polypeptide binding]; other site 768492012742 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 768492012743 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 768492012744 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 768492012745 catalytic residues [active] 768492012746 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 768492012747 TPR motif; other site 768492012748 binding surface 768492012749 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 768492012750 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 768492012751 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 768492012752 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 768492012753 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 768492012754 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 768492012755 Walker A/P-loop; other site 768492012756 ATP binding site [chemical binding]; other site 768492012757 Q-loop/lid; other site 768492012758 ABC transporter signature motif; other site 768492012759 Walker B; other site 768492012760 D-loop; other site 768492012761 H-loop/switch region; other site 768492012762 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768492012763 active site 768492012764 DNA binding site [nucleotide binding] 768492012765 Int/Topo IB signature motif; other site 768492012766 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768492012767 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492012768 DNA binding residues [nucleotide binding] 768492012769 dimerization interface [polypeptide binding]; other site 768492012770 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768492012771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 768492012772 intermolecular recognition site; other site 768492012773 active site 768492012774 dimerization interface [polypeptide binding]; other site 768492012775 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492012776 DNA binding residues [nucleotide binding] 768492012777 dimerization interface [polypeptide binding]; other site 768492012778 Fimbrial protein; Region: Fimbrial; cl01416 768492012779 Fimbrial protein; Region: Fimbrial; cl01416 768492012780 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 768492012781 PapC N-terminal domain; Region: PapC_N; pfam13954 768492012782 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 768492012783 PapC C-terminal domain; Region: PapC_C; pfam13953 768492012784 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 768492012785 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 768492012786 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 768492012787 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 768492012788 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768492012789 active site 768492012790 DNA binding site [nucleotide binding] 768492012791 Int/Topo IB signature motif; other site 768492012792 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768492012793 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 768492012794 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 768492012795 dimer interface [polypeptide binding]; other site 768492012796 active site 768492012797 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 768492012798 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 768492012799 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768492012800 Walker A/P-loop; other site 768492012801 ATP binding site [chemical binding]; other site 768492012802 Q-loop/lid; other site 768492012803 ABC transporter signature motif; other site 768492012804 Walker B; other site 768492012805 D-loop; other site 768492012806 H-loop/switch region; other site 768492012807 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768492012808 FtsX-like permease family; Region: FtsX; pfam02687 768492012809 macrolide transporter subunit MacA; Provisional; Region: PRK11578 768492012810 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768492012811 HlyD family secretion protein; Region: HlyD_3; pfam13437 768492012812 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 768492012813 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 768492012814 putative active site [active] 768492012815 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768492012816 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768492012817 Walker A/P-loop; other site 768492012818 ATP binding site [chemical binding]; other site 768492012819 Q-loop/lid; other site 768492012820 ABC transporter signature motif; other site 768492012821 Walker B; other site 768492012822 D-loop; other site 768492012823 H-loop/switch region; other site 768492012824 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 768492012825 catalytic residues [active] 768492012826 hinge region; other site 768492012827 alpha helical domain; other site 768492012828 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492012829 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492012830 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492012831 putative effector binding pocket; other site 768492012832 dimerization interface [polypeptide binding]; other site 768492012833 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 768492012834 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 768492012835 phosphate binding site [ion binding]; other site 768492012836 BCCT family transporter; Region: BCCT; pfam02028 768492012837 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 768492012838 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768492012839 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 768492012840 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492012841 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492012842 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492012843 putative effector binding pocket; other site 768492012844 dimerization interface [polypeptide binding]; other site 768492012845 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 768492012846 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768492012847 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 768492012848 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 768492012849 Walker A/P-loop; other site 768492012850 ATP binding site [chemical binding]; other site 768492012851 Q-loop/lid; other site 768492012852 ABC transporter signature motif; other site 768492012853 Walker B; other site 768492012854 D-loop; other site 768492012855 H-loop/switch region; other site 768492012856 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 768492012857 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 768492012858 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 768492012859 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768492012860 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768492012861 Cytochrome c; Region: Cytochrom_C; pfam00034 768492012862 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 768492012863 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768492012864 Peptidase family M23; Region: Peptidase_M23; pfam01551 768492012865 acid-resistance membrane protein; Provisional; Region: PRK10209 768492012866 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 768492012867 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 768492012868 HSP70 interaction site [polypeptide binding]; other site 768492012869 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 768492012870 substrate binding site [polypeptide binding]; other site 768492012871 dimer interface [polypeptide binding]; other site 768492012872 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 768492012873 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 768492012874 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492012875 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492012876 LysR substrate binding domain; Region: LysR_substrate; pfam03466 768492012877 dimerization interface [polypeptide binding]; other site 768492012878 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 768492012879 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 768492012880 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 768492012881 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768492012882 DNA-binding site [nucleotide binding]; DNA binding site 768492012883 RNA-binding motif; other site 768492012884 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 768492012885 Excisionase-like protein; Region: Exc; pfam07825 768492012886 Excisionase-like protein; Region: Exc; pfam07825 768492012887 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 768492012888 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 768492012889 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 768492012890 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 768492012891 AntA/AntB antirepressor; Region: AntA; pfam08346 768492012892 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 768492012893 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 768492012894 integrase; Provisional; Region: PRK09692 768492012895 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 768492012896 active site 768492012897 Int/Topo IB signature motif; other site 768492012898 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 768492012899 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 768492012900 dimer interface [polypeptide binding]; other site 768492012901 putative anticodon binding site; other site 768492012902 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 768492012903 motif 1; other site 768492012904 active site 768492012905 motif 2; other site 768492012906 motif 3; other site 768492012907 peptide chain release factor 2; Validated; Region: prfB; PRK00578 768492012908 This domain is found in peptide chain release factors; Region: PCRF; smart00937 768492012909 RF-1 domain; Region: RF-1; pfam00472 768492012910 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 768492012911 DHH family; Region: DHH; pfam01368 768492012912 DHHA1 domain; Region: DHHA1; pfam02272 768492012913 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 768492012914 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 768492012915 dimerization domain [polypeptide binding]; other site 768492012916 dimer interface [polypeptide binding]; other site 768492012917 catalytic residues [active] 768492012918 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 768492012919 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 768492012920 active site 768492012921 Int/Topo IB signature motif; other site 768492012922 flavodoxin FldB; Provisional; Region: PRK12359 768492012923 Inner membrane protein CreD; Region: CreD; pfam06123 768492012924 sensory histidine kinase CreC; Provisional; Region: PRK11100 768492012925 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768492012926 dimerization interface [polypeptide binding]; other site 768492012927 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492012928 dimer interface [polypeptide binding]; other site 768492012929 phosphorylation site [posttranslational modification] 768492012930 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492012931 ATP binding site [chemical binding]; other site 768492012932 Mg2+ binding site [ion binding]; other site 768492012933 G-X-G motif; other site 768492012934 DNA-binding response regulator CreB; Provisional; Region: PRK11083 768492012935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492012936 active site 768492012937 phosphorylation site [posttranslational modification] 768492012938 intermolecular recognition site; other site 768492012939 dimerization interface [polypeptide binding]; other site 768492012940 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768492012941 DNA binding site [nucleotide binding] 768492012942 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 768492012943 hypothetical protein; Provisional; Region: PRK10878 768492012944 putative global regulator; Reviewed; Region: PRK09559 768492012945 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 768492012946 hemolysin; Provisional; Region: PRK15087 768492012947 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 768492012948 HD domain; Region: HD_3; pfam13023 768492012949 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492012950 metabolite-proton symporter; Region: 2A0106; TIGR00883 768492012951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492012952 amidase; Provisional; Region: PRK07056 768492012953 Amidase; Region: Amidase; cl11426 768492012954 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 768492012955 Transcriptional regulators [Transcription]; Region: GntR; COG1802 768492012956 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492012957 DNA-binding site [nucleotide binding]; DNA binding site 768492012958 FCD domain; Region: FCD; pfam07729 768492012959 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 768492012960 classical (c) SDRs; Region: SDR_c; cd05233 768492012961 NAD(P) binding site [chemical binding]; other site 768492012962 active site 768492012963 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 768492012964 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 768492012965 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492012966 active site 768492012967 phosphorylation site [posttranslational modification] 768492012968 intermolecular recognition site; other site 768492012969 dimerization interface [polypeptide binding]; other site 768492012970 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768492012971 DNA binding site [nucleotide binding] 768492012972 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492012973 dimer interface [polypeptide binding]; other site 768492012974 phosphorylation site [posttranslational modification] 768492012975 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492012976 ATP binding site [chemical binding]; other site 768492012977 Mg2+ binding site [ion binding]; other site 768492012978 G-X-G motif; other site 768492012979 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 768492012980 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 768492012981 NAD(P) binding site [chemical binding]; other site 768492012982 glycine dehydrogenase; Provisional; Region: PRK05367 768492012983 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 768492012984 tetramer interface [polypeptide binding]; other site 768492012985 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492012986 catalytic residue [active] 768492012987 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 768492012988 tetramer interface [polypeptide binding]; other site 768492012989 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492012990 catalytic residue [active] 768492012991 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 768492012992 lipoyl attachment site [posttranslational modification]; other site 768492012993 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 768492012994 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 768492012995 oxidoreductase; Provisional; Region: PRK08013 768492012996 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 768492012997 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 768492012998 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 768492012999 proline aminopeptidase P II; Provisional; Region: PRK10879 768492013000 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 768492013001 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 768492013002 active site 768492013003 hypothetical protein; Reviewed; Region: PRK01736 768492013004 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 768492013005 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 768492013006 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 768492013007 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 768492013008 ligand binding site [chemical binding]; other site 768492013009 NAD binding site [chemical binding]; other site 768492013010 tetramer interface [polypeptide binding]; other site 768492013011 catalytic site [active] 768492013012 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 768492013013 L-serine binding site [chemical binding]; other site 768492013014 ACT domain interface; other site 768492013015 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 768492013016 tetramer (dimer of dimers) interface [polypeptide binding]; other site 768492013017 active site 768492013018 dimer interface [polypeptide binding]; other site 768492013019 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 768492013020 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492013021 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 768492013022 putative dimerization interface [polypeptide binding]; other site 768492013023 oxidative stress defense protein; Provisional; Region: PRK11087 768492013024 Uncharacterized conserved protein [Function unknown]; Region: COG2968 768492013025 arginine exporter protein; Provisional; Region: PRK09304 768492013026 Transcriptional regulator [Transcription]; Region: IclR; COG1414 768492013027 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 768492013028 Bacterial transcriptional regulator; Region: IclR; pfam01614 768492013029 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 768492013030 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768492013031 Walker A/P-loop; other site 768492013032 ATP binding site [chemical binding]; other site 768492013033 Q-loop/lid; other site 768492013034 ABC transporter signature motif; other site 768492013035 Walker B; other site 768492013036 D-loop; other site 768492013037 H-loop/switch region; other site 768492013038 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768492013039 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768492013040 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768492013041 TM-ABC transporter signature motif; other site 768492013042 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_6; cd06315 768492013043 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 768492013044 putative ligand binding site [chemical binding]; other site 768492013045 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 768492013046 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 768492013047 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 768492013048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492013049 D-galactonate transporter; Region: 2A0114; TIGR00893 768492013050 putative substrate translocation pore; other site 768492013051 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 768492013052 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 768492013053 putative N- and C-terminal domain interface [polypeptide binding]; other site 768492013054 putative active site [active] 768492013055 MgATP binding site [chemical binding]; other site 768492013056 catalytic site [active] 768492013057 metal binding site [ion binding]; metal-binding site 768492013058 putative xylulose binding site [chemical binding]; other site 768492013059 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 768492013060 active site 768492013061 dimer interface [polypeptide binding]; other site 768492013062 magnesium binding site [ion binding]; other site 768492013063 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 768492013064 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 768492013065 AP (apurinic/apyrimidinic) site pocket; other site 768492013066 DNA interaction; other site 768492013067 Metal-binding active site; metal-binding site 768492013068 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 768492013069 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 768492013070 intersubunit interface [polypeptide binding]; other site 768492013071 active site 768492013072 Zn2+ binding site [ion binding]; other site 768492013073 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 768492013074 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 768492013075 active site 768492013076 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 768492013077 mechanosensitive channel MscS; Provisional; Region: PRK10334 768492013078 Mechanosensitive ion channel; Region: MS_channel; pfam00924 768492013079 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 768492013080 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 768492013081 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 768492013082 active site 768492013083 intersubunit interface [polypeptide binding]; other site 768492013084 zinc binding site [ion binding]; other site 768492013085 Na+ binding site [ion binding]; other site 768492013086 Phosphoglycerate kinase; Region: PGK; pfam00162 768492013087 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 768492013088 substrate binding site [chemical binding]; other site 768492013089 hinge regions; other site 768492013090 ADP binding site [chemical binding]; other site 768492013091 catalytic site [active] 768492013092 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 768492013093 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 768492013094 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 768492013095 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 768492013096 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768492013097 Walker A/P-loop; other site 768492013098 ATP binding site [chemical binding]; other site 768492013099 Q-loop/lid; other site 768492013100 ABC transporter signature motif; other site 768492013101 Walker B; other site 768492013102 D-loop; other site 768492013103 H-loop/switch region; other site 768492013104 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 768492013105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492013106 dimer interface [polypeptide binding]; other site 768492013107 conserved gate region; other site 768492013108 ABC-ATPase subunit interface; other site 768492013109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492013110 dimer interface [polypeptide binding]; other site 768492013111 conserved gate region; other site 768492013112 putative PBP binding loops; other site 768492013113 ABC-ATPase subunit interface; other site 768492013114 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 768492013115 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 768492013116 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768492013117 catalytic core [active] 768492013118 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 768492013119 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 768492013120 transmembrane helices; other site 768492013121 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492013122 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492013123 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 768492013124 putative dimerization interface [polypeptide binding]; other site 768492013125 transketolase; Reviewed; Region: PRK12753 768492013126 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 768492013127 TPP-binding site [chemical binding]; other site 768492013128 dimer interface [polypeptide binding]; other site 768492013129 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 768492013130 PYR/PP interface [polypeptide binding]; other site 768492013131 dimer interface [polypeptide binding]; other site 768492013132 TPP binding site [chemical binding]; other site 768492013133 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768492013134 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 768492013135 hypothetical protein; Provisional; Region: PRK07064 768492013136 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768492013137 PYR/PP interface [polypeptide binding]; other site 768492013138 dimer interface [polypeptide binding]; other site 768492013139 TPP binding site [chemical binding]; other site 768492013140 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768492013141 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 768492013142 TPP-binding site [chemical binding]; other site 768492013143 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 768492013144 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 768492013145 NAD(P) binding site [chemical binding]; other site 768492013146 catalytic residues [active] 768492013147 L-aspartate dehydrogenase; Provisional; Region: PRK13303 768492013148 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 768492013149 Domain of unknown function DUF108; Region: DUF108; pfam01958 768492013150 short chain dehydrogenase; Provisional; Region: PRK07062 768492013151 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492013152 NAD(P) binding site [chemical binding]; other site 768492013153 active site 768492013154 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 768492013155 Cupin domain; Region: Cupin_2; pfam07883 768492013156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492013157 D-galactonate transporter; Region: 2A0114; TIGR00893 768492013158 putative substrate translocation pore; other site 768492013159 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 768492013160 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768492013161 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 768492013162 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768492013163 putative active site [active] 768492013164 putative metal binding site [ion binding]; other site 768492013165 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 768492013166 Transcriptional regulator [Transcription]; Region: IclR; COG1414 768492013167 Bacterial transcriptional regulator; Region: IclR; pfam01614 768492013168 short chain dehydrogenase; Provisional; Region: PRK12939 768492013169 classical (c) SDRs; Region: SDR_c; cd05233 768492013170 NAD(P) binding site [chemical binding]; other site 768492013171 active site 768492013172 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 768492013173 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 768492013174 [2Fe-2S] cluster binding site [ion binding]; other site 768492013175 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 768492013176 hydrophobic ligand binding site; other site 768492013177 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 768492013178 [2Fe-2S] cluster binding site [ion binding]; other site 768492013179 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 768492013180 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768492013181 RNA binding surface [nucleotide binding]; other site 768492013182 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 768492013183 probable active site [active] 768492013184 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 768492013185 agmatinase; Region: agmatinase; TIGR01230 768492013186 oligomer interface [polypeptide binding]; other site 768492013187 putative active site [active] 768492013188 Mn binding site [ion binding]; other site 768492013189 arginine decarboxylase; Provisional; Region: PRK05354 768492013190 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 768492013191 dimer interface [polypeptide binding]; other site 768492013192 active site 768492013193 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768492013194 catalytic residues [active] 768492013195 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 768492013196 S-adenosylmethionine synthetase; Validated; Region: PRK05250 768492013197 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 768492013198 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 768492013199 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 768492013200 Hok/gef family; Region: HOK_GEF; pfam01848 768492013201 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 768492013202 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768492013203 ABC-ATPase subunit interface; other site 768492013204 dimer interface [polypeptide binding]; other site 768492013205 putative PBP binding regions; other site 768492013206 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768492013207 ABC-ATPase subunit interface; other site 768492013208 dimer interface [polypeptide binding]; other site 768492013209 putative PBP binding regions; other site 768492013210 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 768492013211 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 768492013212 siderophore binding site; other site 768492013213 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 768492013214 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768492013215 Walker A/P-loop; other site 768492013216 ATP binding site [chemical binding]; other site 768492013217 Q-loop/lid; other site 768492013218 ABC transporter signature motif; other site 768492013219 Walker B; other site 768492013220 D-loop; other site 768492013221 H-loop/switch region; other site 768492013222 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 768492013223 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768492013224 N-terminal plug; other site 768492013225 ligand-binding site [chemical binding]; other site 768492013226 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 768492013227 Transglycosylase; Region: Transgly; pfam00912 768492013228 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 768492013229 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 768492013230 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768492013231 ATP binding site [chemical binding]; other site 768492013232 putative Mg++ binding site [ion binding]; other site 768492013233 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768492013234 nucleotide binding region [chemical binding]; other site 768492013235 ATP-binding site [chemical binding]; other site 768492013236 Helicase associated domain (HA2); Region: HA2; pfam04408 768492013237 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 768492013238 2'-5' RNA ligase; Provisional; Region: PRK15124 768492013239 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 768492013240 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 768492013241 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 768492013242 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 768492013243 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 768492013244 active site 768492013245 nucleotide binding site [chemical binding]; other site 768492013246 HIGH motif; other site 768492013247 KMSKS motif; other site 768492013248 poly(A) polymerase; Region: pcnB; TIGR01942 768492013249 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 768492013250 active site 768492013251 NTP binding site [chemical binding]; other site 768492013252 metal binding triad [ion binding]; metal-binding site 768492013253 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 768492013254 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 768492013255 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 768492013256 catalytic center binding site [active] 768492013257 ATP binding site [chemical binding]; other site 768492013258 sensor protein QseC; Provisional; Region: PRK10337 768492013259 HAMP domain; Region: HAMP; pfam00672 768492013260 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492013261 dimer interface [polypeptide binding]; other site 768492013262 phosphorylation site [posttranslational modification] 768492013263 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492013264 ATP binding site [chemical binding]; other site 768492013265 Mg2+ binding site [ion binding]; other site 768492013266 G-X-G motif; other site 768492013267 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 768492013268 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492013269 active site 768492013270 phosphorylation site [posttranslational modification] 768492013271 intermolecular recognition site; other site 768492013272 dimerization interface [polypeptide binding]; other site 768492013273 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768492013274 DNA binding site [nucleotide binding] 768492013275 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 768492013276 oligomerization interface [polypeptide binding]; other site 768492013277 active site 768492013278 metal binding site [ion binding]; metal-binding site 768492013279 Pantoate-beta-alanine ligase; Region: PanC; cd00560 768492013280 pantoate--beta-alanine ligase; Region: panC; TIGR00018 768492013281 active site 768492013282 ATP-binding site [chemical binding]; other site 768492013283 pantoate-binding site; other site 768492013284 HXXH motif; other site 768492013285 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 768492013286 tetramerization interface [polypeptide binding]; other site 768492013287 active site 768492013288 Bacterial SH3 domain; Region: SH3_3; cl17532 768492013289 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 768492013290 putative active site [active] 768492013291 putative metal binding site [ion binding]; other site 768492013292 inner membrane transport permease; Provisional; Region: PRK15066 768492013293 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 768492013294 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 768492013295 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 768492013296 Walker A/P-loop; other site 768492013297 ATP binding site [chemical binding]; other site 768492013298 Q-loop/lid; other site 768492013299 ABC transporter signature motif; other site 768492013300 Walker B; other site 768492013301 D-loop; other site 768492013302 H-loop/switch region; other site 768492013303 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 768492013304 active site clefts [active] 768492013305 zinc binding site [ion binding]; other site 768492013306 dimer interface [polypeptide binding]; other site 768492013307 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768492013308 active site 768492013309 multicopper oxidase; Provisional; Region: PRK10965 768492013310 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 768492013311 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 768492013312 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 768492013313 spermidine synthase; Provisional; Region: PRK00811 768492013314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492013315 S-adenosylmethionine binding site [chemical binding]; other site 768492013316 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 768492013317 hypothetical protein; Provisional; Region: PRK05248 768492013318 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 768492013319 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 768492013320 substrate binding site [chemical binding]; other site 768492013321 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 768492013322 substrate binding site [chemical binding]; other site 768492013323 ligand binding site [chemical binding]; other site 768492013324 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 768492013325 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768492013326 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768492013327 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768492013328 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 768492013329 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768492013330 E3 interaction surface; other site 768492013331 lipoyl attachment site [posttranslational modification]; other site 768492013332 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768492013333 E3 interaction surface; other site 768492013334 lipoyl attachment site [posttranslational modification]; other site 768492013335 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768492013336 E3 interaction surface; other site 768492013337 lipoyl attachment site [posttranslational modification]; other site 768492013338 e3 binding domain; Region: E3_binding; pfam02817 768492013339 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 768492013340 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 768492013341 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 768492013342 dimer interface [polypeptide binding]; other site 768492013343 TPP-binding site [chemical binding]; other site 768492013344 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 768492013345 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492013346 DNA-binding site [nucleotide binding]; DNA binding site 768492013347 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 768492013348 aromatic amino acid transporter; Provisional; Region: PRK10238 768492013349 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 768492013350 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492013351 putative substrate translocation pore; other site 768492013352 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 768492013353 active site 768492013354 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768492013355 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768492013356 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 768492013357 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 768492013358 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 768492013359 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 768492013360 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 768492013361 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768492013362 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 768492013363 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768492013364 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 768492013365 Ligand binding site; other site 768492013366 metal-binding site 768492013367 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 768492013368 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 768492013369 XdhC Rossmann domain; Region: XdhC_C; pfam13478 768492013370 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 768492013371 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492013372 fumarate hydratase; Provisional; Region: PRK15389 768492013373 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 768492013374 Fumarase C-terminus; Region: Fumerase_C; pfam05683 768492013375 hypothetical protein; Provisional; Region: PRK04860 768492013376 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 768492013377 DNA-specific endonuclease I; Provisional; Region: PRK15137 768492013378 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 768492013379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 768492013380 RNA methyltransferase, RsmE family; Region: TIGR00046 768492013381 glutathione synthetase; Provisional; Region: PRK05246 768492013382 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 768492013383 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 768492013384 hypothetical protein; Validated; Region: PRK00228 768492013385 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 768492013386 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 768492013387 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 768492013388 Walker A motif; other site 768492013389 ATP binding site [chemical binding]; other site 768492013390 Walker B motif; other site 768492013391 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 768492013392 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768492013393 catalytic residue [active] 768492013394 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 768492013395 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 768492013396 YGGT family; Region: YGGT; pfam02325 768492013397 YGGT family; Region: YGGT; pfam02325 768492013398 hypothetical protein; Validated; Region: PRK05090 768492013399 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 768492013400 active site 768492013401 dimerization interface [polypeptide binding]; other site 768492013402 HemN family oxidoreductase; Provisional; Region: PRK05660 768492013403 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768492013404 FeS/SAM binding site; other site 768492013405 HemN C-terminal domain; Region: HemN_C; pfam06969 768492013406 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 768492013407 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 768492013408 hypothetical protein; Provisional; Region: PRK10626 768492013409 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 768492013410 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 768492013411 glutaminase; Provisional; Region: PRK00971 768492013412 hypothetical protein; Provisional; Region: PRK11702 768492013413 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492013414 S-adenosylmethionine binding site [chemical binding]; other site 768492013415 adenine DNA glycosylase; Provisional; Region: PRK10880 768492013416 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 768492013417 minor groove reading motif; other site 768492013418 helix-hairpin-helix signature motif; other site 768492013419 substrate binding pocket [chemical binding]; other site 768492013420 active site 768492013421 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 768492013422 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 768492013423 DNA binding and oxoG recognition site [nucleotide binding] 768492013424 oxidative damage protection protein; Provisional; Region: PRK05408 768492013425 murein transglycosylase C; Provisional; Region: mltC; PRK11671 768492013426 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 768492013427 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768492013428 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768492013429 catalytic residue [active] 768492013430 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 768492013431 2-methylcitrate dehydratase; Region: prpD; TIGR02330 768492013432 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 768492013433 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 768492013434 dimer interface [polypeptide binding]; other site 768492013435 active site 768492013436 citrylCoA binding site [chemical binding]; other site 768492013437 oxalacetate/citrate binding site [chemical binding]; other site 768492013438 coenzyme A binding site [chemical binding]; other site 768492013439 catalytic triad [active] 768492013440 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 768492013441 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 768492013442 tetramer interface [polypeptide binding]; other site 768492013443 active site 768492013444 Mg2+/Mn2+ binding site [ion binding]; other site 768492013445 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 768492013446 Propionate catabolism activator; Region: PrpR_N; pfam06506 768492013447 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492013448 Walker A motif; other site 768492013449 ATP binding site [chemical binding]; other site 768492013450 Walker B motif; other site 768492013451 arginine finger; other site 768492013452 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768492013453 ornithine decarboxylase; Provisional; Region: PRK13578 768492013454 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 768492013455 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 768492013456 homodimer interface [polypeptide binding]; other site 768492013457 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492013458 catalytic residue [active] 768492013459 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 768492013460 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 768492013461 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 768492013462 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492013463 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492013464 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492013465 dimerization interface [polypeptide binding]; other site 768492013466 Predicted transcriptional regulators [Transcription]; Region: COG1733 768492013467 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768492013468 dimerization interface [polypeptide binding]; other site 768492013469 putative DNA binding site [nucleotide binding]; other site 768492013470 putative Zn2+ binding site [ion binding]; other site 768492013471 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 768492013472 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 768492013473 classical (c) SDRs; Region: SDR_c; cd05233 768492013474 NAD(P) binding site [chemical binding]; other site 768492013475 active site 768492013476 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 768492013477 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 768492013478 Flavin Reductases; Region: FlaRed; cl00801 768492013479 This alignment model represents the N-terminal rieske domain of the oxygenase alpha subunit of aminopyrrolnitrin oxygenase (PrnD). PrnD is a novel Rieske N-oxygenase that catalyzes the final step in the pyrrolnitrin biosynthetic pathway, the oxidation...; Region: Rieske_RO_Alpha_PrnD; cd03537 768492013480 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 768492013481 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 768492013482 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 768492013483 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768492013484 Domain of unknown function (DUF1864); Region: DUF1864; pfam08933 768492013485 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 768492013486 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 768492013487 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 768492013488 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 768492013489 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 768492013490 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 768492013491 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 768492013492 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 768492013493 Walker A/P-loop; other site 768492013494 ATP binding site [chemical binding]; other site 768492013495 Q-loop/lid; other site 768492013496 ABC transporter signature motif; other site 768492013497 Walker B; other site 768492013498 D-loop; other site 768492013499 H-loop/switch region; other site 768492013500 Condensation domain; Region: Condensation; pfam00668 768492013501 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 768492013502 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 768492013503 active site 768492013504 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 768492013505 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 768492013506 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 768492013507 putative NADP binding site [chemical binding]; other site 768492013508 active site 768492013509 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768492013510 Condensation domain; Region: Condensation; pfam00668 768492013511 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 768492013512 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 768492013513 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 768492013514 acyl-activating enzyme (AAE) consensus motif; other site 768492013515 AMP binding site [chemical binding]; other site 768492013516 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768492013517 Condensation domain; Region: Condensation; pfam00668 768492013518 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 768492013519 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 768492013520 acyl-activating enzyme (AAE) consensus motif; other site 768492013521 AMP binding site [chemical binding]; other site 768492013522 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768492013523 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 768492013524 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 768492013525 acyl-activating enzyme (AAE) consensus motif; other site 768492013526 AMP binding site [chemical binding]; other site 768492013527 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768492013528 peptide synthase; Provisional; Region: PRK12467 768492013529 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 768492013530 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 768492013531 acyl-activating enzyme (AAE) consensus motif; other site 768492013532 AMP binding site [chemical binding]; other site 768492013533 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768492013534 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 768492013535 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 768492013536 acyl-activating enzyme (AAE) consensus motif; other site 768492013537 AMP binding site [chemical binding]; other site 768492013538 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768492013539 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 768492013540 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 768492013541 acyl-activating enzyme (AAE) consensus motif; other site 768492013542 AMP binding site [chemical binding]; other site 768492013543 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768492013544 C-N hydrolase family amidase; Provisional; Region: PRK10438 768492013545 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 768492013546 putative active site [active] 768492013547 catalytic triad [active] 768492013548 dimer interface [polypeptide binding]; other site 768492013549 multimer interface [polypeptide binding]; other site 768492013550 thioester reductase domain; Region: Thioester-redct; TIGR01746 768492013551 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 768492013552 putative NAD(P) binding site [chemical binding]; other site 768492013553 active site 768492013554 putative substrate binding site [chemical binding]; other site 768492013555 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 768492013556 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492013557 NAD(P) binding site [chemical binding]; other site 768492013558 active site 768492013559 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 768492013560 FMN binding site [chemical binding]; other site 768492013561 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 768492013562 substrate binding site [chemical binding]; other site 768492013563 putative catalytic residue [active] 768492013564 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768492013565 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 768492013566 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492013567 catalytic residue [active] 768492013568 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 768492013569 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 768492013570 active site 768492013571 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 768492013572 active site 768492013573 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 768492013574 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 768492013575 active site 2 [active] 768492013576 active site 1 [active] 768492013577 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 768492013578 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 768492013579 active site 768492013580 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 768492013581 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 768492013582 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 768492013583 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 768492013584 putative NADP binding site [chemical binding]; other site 768492013585 active site 768492013586 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 768492013587 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768492013588 FtsX-like permease family; Region: FtsX; pfam02687 768492013589 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768492013590 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768492013591 Walker A/P-loop; other site 768492013592 ATP binding site [chemical binding]; other site 768492013593 Q-loop/lid; other site 768492013594 ABC transporter signature motif; other site 768492013595 Walker B; other site 768492013596 D-loop; other site 768492013597 H-loop/switch region; other site 768492013598 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 768492013599 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 768492013600 HlyD family secretion protein; Region: HlyD_3; pfam13437 768492013601 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 768492013602 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 768492013603 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 768492013604 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 768492013605 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492013606 catalytic residue [active] 768492013607 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 768492013608 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768492013609 PYR/PP interface [polypeptide binding]; other site 768492013610 dimer interface [polypeptide binding]; other site 768492013611 TPP binding site [chemical binding]; other site 768492013612 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768492013613 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 768492013614 TPP-binding site [chemical binding]; other site 768492013615 dimer interface [polypeptide binding]; other site 768492013616 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 768492013617 putative active site pocket [active] 768492013618 dimerization interface [polypeptide binding]; other site 768492013619 putative catalytic residue [active] 768492013620 Phosphopantetheine attachment site; Region: PP-binding; cl09936 768492013621 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 768492013622 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 768492013623 C-terminal domain interface [polypeptide binding]; other site 768492013624 GSH binding site (G-site) [chemical binding]; other site 768492013625 dimer interface [polypeptide binding]; other site 768492013626 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 768492013627 dimer interface [polypeptide binding]; other site 768492013628 N-terminal domain interface [polypeptide binding]; other site 768492013629 substrate binding pocket (H-site) [chemical binding]; other site 768492013630 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 768492013631 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 768492013632 homodimer interface [polypeptide binding]; other site 768492013633 substrate-cofactor binding pocket; other site 768492013634 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492013635 catalytic residue [active] 768492013636 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 768492013637 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 768492013638 active site pocket [active] 768492013639 Benzoate membrane transport protein; Region: BenE; pfam03594 768492013640 benzoate transporter; Region: benE; TIGR00843 768492013641 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 768492013642 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 768492013643 active site 768492013644 non-prolyl cis peptide bond; other site 768492013645 cystathionine beta-lyase; Provisional; Region: PRK05967 768492013646 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768492013647 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492013648 catalytic residue [active] 768492013649 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 768492013650 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492013651 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492013652 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492013653 dimerization interface [polypeptide binding]; other site 768492013654 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 768492013655 GAF domain; Region: GAF; cl17456 768492013656 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 768492013657 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492013658 Walker A motif; other site 768492013659 ATP binding site [chemical binding]; other site 768492013660 Walker B motif; other site 768492013661 arginine finger; other site 768492013662 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 768492013663 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 768492013664 dimerization interface [polypeptide binding]; other site 768492013665 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 768492013666 ATP binding site [chemical binding]; other site 768492013667 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 768492013668 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 768492013669 HupF/HypC family; Region: HupF_HypC; cl00394 768492013670 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 768492013671 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 768492013672 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 768492013673 Transcriptional repressor of hyc and hyp operons; Region: HycA_repressor; cl08095 768492013674 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 768492013675 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 768492013676 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 768492013677 NADH dehydrogenase; Region: NADHdh; cl00469 768492013678 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 768492013679 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 768492013680 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 768492013681 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 768492013682 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768492013683 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 768492013684 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 768492013685 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 768492013686 nickel binding site [ion binding]; other site 768492013687 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 768492013688 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 768492013689 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 768492013690 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 768492013691 [4Fe-4S] binding site [ion binding]; other site 768492013692 molybdopterin cofactor binding site; other site 768492013693 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 768492013694 molybdopterin cofactor binding site; other site 768492013695 Acylphosphatase; Region: Acylphosphatase; pfam00708 768492013696 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 768492013697 HypF finger; Region: zf-HYPF; pfam07503 768492013698 HypF finger; Region: zf-HYPF; pfam07503 768492013699 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 768492013700 High-affinity nickel-transport protein; Region: NicO; cl00964 768492013701 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492013702 Coenzyme A binding pocket [chemical binding]; other site 768492013703 PAS fold; Region: PAS_4; pfam08448 768492013704 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768492013705 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492013706 DNA binding residues [nucleotide binding] 768492013707 dimerization interface [polypeptide binding]; other site 768492013708 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 768492013709 Na binding site [ion binding]; other site 768492013710 NIPSNAP; Region: NIPSNAP; pfam07978 768492013711 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492013712 non-specific DNA binding site [nucleotide binding]; other site 768492013713 salt bridge; other site 768492013714 sequence-specific DNA binding site [nucleotide binding]; other site 768492013715 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 768492013716 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 768492013717 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 768492013718 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 768492013719 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 768492013720 Phosphoesterase family; Region: Phosphoesterase; pfam04185 768492013721 Domain of unknown function (DUF756); Region: DUF756; pfam05506 768492013722 Domain of unknown function (DUF756); Region: DUF756; pfam05506 768492013723 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 768492013724 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768492013725 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768492013726 salt bridge; other site 768492013727 non-specific DNA binding site [nucleotide binding]; other site 768492013728 sequence-specific DNA binding site [nucleotide binding]; other site 768492013729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492013730 putative substrate translocation pore; other site 768492013731 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 768492013732 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 768492013733 Protein of unknown function, DUF596; Region: DUF596; cl10492 768492013734 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768492013735 anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154 768492013736 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 768492013737 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 768492013738 haemagglutination activity domain; Region: Haemagg_act; pfam05860 768492013739 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 768492013740 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768492013741 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768492013742 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768492013743 RTX toxin acyltransferase family; Region: HlyC; pfam02794 768492013744 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 768492013745 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 768492013746 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 768492013747 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768492013748 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 768492013749 putative substrate binding site [chemical binding]; other site 768492013750 putative ATP binding site [chemical binding]; other site 768492013751 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768492013752 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 768492013753 active site turn [active] 768492013754 phosphorylation site [posttranslational modification] 768492013755 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768492013756 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 768492013757 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 768492013758 substrate binding [chemical binding]; other site 768492013759 active site 768492013760 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 768492013761 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 768492013762 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492013763 DNA binding site [nucleotide binding] 768492013764 domain linker motif; other site 768492013765 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 768492013766 dimerization interface [polypeptide binding]; other site 768492013767 ligand binding site [chemical binding]; other site 768492013768 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 768492013769 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 768492013770 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 768492013771 shikimate binding site; other site 768492013772 NAD(P) binding site [chemical binding]; other site 768492013773 biopolymer transport protein ExbD; Provisional; Region: PRK11267 768492013774 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 768492013775 biopolymer transport protein ExbB; Provisional; Region: PRK10414 768492013776 cystathionine beta-lyase; Provisional; Region: PRK08114 768492013777 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 768492013778 homodimer interface [polypeptide binding]; other site 768492013779 substrate-cofactor binding pocket; other site 768492013780 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492013781 catalytic residue [active] 768492013782 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 768492013783 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 768492013784 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492013785 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492013786 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 768492013787 putative effector binding pocket; other site 768492013788 putative dimerization interface [polypeptide binding]; other site 768492013789 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 768492013790 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 768492013791 putative NAD(P) binding site [chemical binding]; other site 768492013792 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 768492013793 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768492013794 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492013795 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492013796 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 768492013797 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 768492013798 dimer interface [polypeptide binding]; other site 768492013799 active site 768492013800 metal binding site [ion binding]; metal-binding site 768492013801 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768492013802 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768492013803 active site 768492013804 catalytic tetrad [active] 768492013805 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 768492013806 beta-galactosidase; Region: BGL; TIGR03356 768492013807 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 768492013808 methionine cluster; other site 768492013809 active site 768492013810 phosphorylation site [posttranslational modification] 768492013811 metal binding site [ion binding]; metal-binding site 768492013812 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 768492013813 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 768492013814 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 768492013815 active site 768492013816 P-loop; other site 768492013817 phosphorylation site [posttranslational modification] 768492013818 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 768492013819 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768492013820 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768492013821 catalytic residue [active] 768492013822 hypothetical protein; Provisional; Region: PRK01254 768492013823 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 768492013824 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 768492013825 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 768492013826 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768492013827 substrate binding site [chemical binding]; other site 768492013828 ATP binding site [chemical binding]; other site 768492013829 nucleoside transporter; Region: 2A0110; TIGR00889 768492013830 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492013831 purine nucleoside phosphorylase; Provisional; Region: PRK08202 768492013832 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 768492013833 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492013834 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 768492013835 putative dimerization interface [polypeptide binding]; other site 768492013836 putative substrate binding pocket [chemical binding]; other site 768492013837 FtsI repressor; Provisional; Region: PRK10883 768492013838 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 768492013839 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 768492013840 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 768492013841 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 768492013842 putative acyl-acceptor binding pocket; other site 768492013843 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 768492013844 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 768492013845 CAP-like domain; other site 768492013846 active site 768492013847 primary dimer interface [polypeptide binding]; other site 768492013848 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 768492013849 Uncharacterized conserved protein [Function unknown]; Region: COG1359 768492013850 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492013851 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492013852 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492013853 dimerization interface [polypeptide binding]; other site 768492013854 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 768492013855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492013856 ATP binding site [chemical binding]; other site 768492013857 Mg2+ binding site [ion binding]; other site 768492013858 G-X-G motif; other site 768492013859 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 768492013860 anchoring element; other site 768492013861 dimer interface [polypeptide binding]; other site 768492013862 ATP binding site [chemical binding]; other site 768492013863 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 768492013864 active site 768492013865 metal binding site [ion binding]; metal-binding site 768492013866 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 768492013867 esterase YqiA; Provisional; Region: PRK11071 768492013868 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768492013869 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 768492013870 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 768492013871 active site 768492013872 metal binding site [ion binding]; metal-binding site 768492013873 hexamer interface [polypeptide binding]; other site 768492013874 putative dehydrogenase; Provisional; Region: PRK11039 768492013875 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 768492013876 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 768492013877 dimer interface [polypeptide binding]; other site 768492013878 ADP-ribose binding site [chemical binding]; other site 768492013879 active site 768492013880 nudix motif; other site 768492013881 metal binding site [ion binding]; metal-binding site 768492013882 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 768492013883 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 768492013884 GAF domain; Region: GAF; pfam01590 768492013885 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 768492013886 putative active site [active] 768492013887 heme pocket [chemical binding]; other site 768492013888 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492013889 Walker A motif; other site 768492013890 ATP binding site [chemical binding]; other site 768492013891 Walker B motif; other site 768492013892 arginine finger; other site 768492013893 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768492013894 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 768492013895 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 768492013896 active pocket/dimerization site; other site 768492013897 active site 768492013898 phosphorylation site [posttranslational modification] 768492013899 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 768492013900 dimerization domain swap beta strand [polypeptide binding]; other site 768492013901 regulatory protein interface [polypeptide binding]; other site 768492013902 active site 768492013903 regulatory phosphorylation site [posttranslational modification]; other site 768492013904 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 768492013905 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 768492013906 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 768492013907 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 768492013908 Dak1 domain; Region: Dak1; pfam02733 768492013909 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 768492013910 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 768492013911 dimer interface [polypeptide binding]; other site 768492013912 active site 768492013913 metal binding site [ion binding]; metal-binding site 768492013914 hypothetical protein; Provisional; Region: PRK11653 768492013915 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 768492013916 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 768492013917 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 768492013918 putative active site [active] 768492013919 metal binding site [ion binding]; metal-binding site 768492013920 zinc transporter ZupT; Provisional; Region: PRK04201 768492013921 ZIP Zinc transporter; Region: Zip; pfam02535 768492013922 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 768492013923 dimer interface [polypeptide binding]; other site 768492013924 Alkaline phosphatase homologues; Region: alkPPc; smart00098 768492013925 active site 768492013926 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 768492013927 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 768492013928 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 768492013929 putative transporter; Provisional; Region: PRK11021 768492013930 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 768492013931 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 768492013932 putative ribose interaction site [chemical binding]; other site 768492013933 putative ADP binding site [chemical binding]; other site 768492013934 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 768492013935 active site 768492013936 nucleotide binding site [chemical binding]; other site 768492013937 HIGH motif; other site 768492013938 KMSKS motif; other site 768492013939 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 768492013940 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 768492013941 metal binding triad; other site 768492013942 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 768492013943 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 768492013944 metal binding triad; other site 768492013945 Uncharacterized conserved protein [Function unknown]; Region: COG3025 768492013946 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 768492013947 putative active site [active] 768492013948 putative metal binding residues [ion binding]; other site 768492013949 signature motif; other site 768492013950 putative triphosphate binding site [ion binding]; other site 768492013951 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 768492013952 SH3 domain-containing protein; Provisional; Region: PRK10884 768492013953 Bacterial SH3 domain homologues; Region: SH3b; smart00287 768492013954 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 768492013955 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 768492013956 active site 768492013957 NTP binding site [chemical binding]; other site 768492013958 metal binding triad [ion binding]; metal-binding site 768492013959 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 768492013960 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768492013961 Zn2+ binding site [ion binding]; other site 768492013962 Mg2+ binding site [ion binding]; other site 768492013963 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 768492013964 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 768492013965 homooctamer interface [polypeptide binding]; other site 768492013966 active site 768492013967 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 768492013968 UGMP family protein; Validated; Region: PRK09604 768492013969 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 768492013970 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 768492013971 DNA primase; Validated; Region: dnaG; PRK05667 768492013972 CHC2 zinc finger; Region: zf-CHC2; pfam01807 768492013973 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 768492013974 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 768492013975 active site 768492013976 metal binding site [ion binding]; metal-binding site 768492013977 interdomain interaction site; other site 768492013978 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 768492013979 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 768492013980 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 768492013981 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 768492013982 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 768492013983 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 768492013984 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768492013985 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 768492013986 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768492013987 DNA binding residues [nucleotide binding] 768492013988 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 768492013989 active site 768492013990 SUMO-1 interface [polypeptide binding]; other site 768492013991 HPP family; Region: HPP; pfam04982 768492013992 glutathione S-transferase; Provisional; Region: PRK15113 768492013993 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 768492013994 C-terminal domain interface [polypeptide binding]; other site 768492013995 GSH binding site (G-site) [chemical binding]; other site 768492013996 dimer interface [polypeptide binding]; other site 768492013997 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 768492013998 N-terminal domain interface [polypeptide binding]; other site 768492013999 putative dimer interface [polypeptide binding]; other site 768492014000 putative substrate binding pocket (H-site) [chemical binding]; other site 768492014001 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 768492014002 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 768492014003 succinic semialdehyde dehydrogenase; Region: PLN02278 768492014004 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 768492014005 tetramerization interface [polypeptide binding]; other site 768492014006 NAD(P) binding site [chemical binding]; other site 768492014007 catalytic residues [active] 768492014008 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 768492014009 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768492014010 inhibitor-cofactor binding pocket; inhibition site 768492014011 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492014012 catalytic residue [active] 768492014013 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768492014014 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492014015 DNA-binding site [nucleotide binding]; DNA binding site 768492014016 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492014017 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492014018 homodimer interface [polypeptide binding]; other site 768492014019 catalytic residue [active] 768492014020 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 768492014021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768492014022 Walker A/P-loop; other site 768492014023 ATP binding site [chemical binding]; other site 768492014024 Q-loop/lid; other site 768492014025 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768492014026 ABC transporter signature motif; other site 768492014027 Walker B; other site 768492014028 D-loop; other site 768492014029 ABC transporter; Region: ABC_tran_2; pfam12848 768492014030 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768492014031 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 768492014032 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 768492014033 active site 768492014034 FMN binding site [chemical binding]; other site 768492014035 2,4-decadienoyl-CoA binding site; other site 768492014036 catalytic residue [active] 768492014037 4Fe-4S cluster binding site [ion binding]; other site 768492014038 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 768492014039 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768492014040 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 768492014041 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492014042 S-adenosylmethionine binding site [chemical binding]; other site 768492014043 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 768492014044 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768492014045 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768492014046 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 768492014047 catalytic triad [active] 768492014048 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 768492014049 serine/threonine transporter SstT; Provisional; Region: PRK13628 768492014050 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 768492014051 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 768492014052 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 768492014053 galactarate dehydratase; Region: galactar-dH20; TIGR03248 768492014054 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 768492014055 Glucuronate isomerase; Region: UxaC; pfam02614 768492014056 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 768492014057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492014058 D-galactonate transporter; Region: 2A0114; TIGR00893 768492014059 putative substrate translocation pore; other site 768492014060 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 768492014061 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492014062 DNA-binding site [nucleotide binding]; DNA binding site 768492014063 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 768492014064 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 768492014065 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 768492014066 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 768492014067 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 768492014068 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 768492014069 Predicted membrane protein [Function unknown]; Region: COG5393 768492014070 YqjK-like protein; Region: YqjK; pfam13997 768492014071 Predicted membrane protein [Function unknown]; Region: COG2259 768492014072 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 768492014073 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 768492014074 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 768492014075 putative dimer interface [polypeptide binding]; other site 768492014076 N-terminal domain interface [polypeptide binding]; other site 768492014077 putative substrate binding pocket (H-site) [chemical binding]; other site 768492014078 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492014079 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 768492014080 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768492014081 dimerization interface [polypeptide binding]; other site 768492014082 Pirin-related protein [General function prediction only]; Region: COG1741 768492014083 Pirin; Region: Pirin; pfam02678 768492014084 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 768492014085 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 768492014086 putative SAM binding site [chemical binding]; other site 768492014087 putative homodimer interface [polypeptide binding]; other site 768492014088 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 768492014089 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 768492014090 putative ligand binding site [chemical binding]; other site 768492014091 hypothetical protein; Reviewed; Region: PRK12497 768492014092 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 768492014093 dimer interface [polypeptide binding]; other site 768492014094 active site 768492014095 outer membrane lipoprotein; Provisional; Region: PRK11023 768492014096 bacterial OsmY and nodulation domain; Region: BON; smart00749 768492014097 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 768492014098 Transglycosylase; Region: Transgly; cl17702 768492014099 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 768492014100 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 768492014101 conserved cys residue [active] 768492014102 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 768492014103 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768492014104 putative active site [active] 768492014105 heme pocket [chemical binding]; other site 768492014106 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492014107 dimer interface [polypeptide binding]; other site 768492014108 phosphorylation site [posttranslational modification] 768492014109 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492014110 ATP binding site [chemical binding]; other site 768492014111 Mg2+ binding site [ion binding]; other site 768492014112 G-X-G motif; other site 768492014113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492014114 active site 768492014115 phosphorylation site [posttranslational modification] 768492014116 intermolecular recognition site; other site 768492014117 dimerization interface [polypeptide binding]; other site 768492014118 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 768492014119 putative binding surface; other site 768492014120 active site 768492014121 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 768492014122 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768492014123 FeS/SAM binding site; other site 768492014124 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 768492014125 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 768492014126 active site 768492014127 dimer interface [polypeptide binding]; other site 768492014128 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 768492014129 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 768492014130 active site 768492014131 FMN binding site [chemical binding]; other site 768492014132 substrate binding site [chemical binding]; other site 768492014133 3Fe-4S cluster binding site [ion binding]; other site 768492014134 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 768492014135 domain interface; other site 768492014136 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 768492014137 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768492014138 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 768492014139 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768492014140 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 768492014141 stringent starvation protein A; Provisional; Region: sspA; PRK09481 768492014142 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 768492014143 C-terminal domain interface [polypeptide binding]; other site 768492014144 putative GSH binding site (G-site) [chemical binding]; other site 768492014145 dimer interface [polypeptide binding]; other site 768492014146 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 768492014147 dimer interface [polypeptide binding]; other site 768492014148 N-terminal domain interface [polypeptide binding]; other site 768492014149 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 768492014150 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 768492014151 23S rRNA interface [nucleotide binding]; other site 768492014152 L3 interface [polypeptide binding]; other site 768492014153 Predicted ATPase [General function prediction only]; Region: COG1485 768492014154 hypothetical protein; Provisional; Region: PRK11677 768492014155 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 768492014156 serine endoprotease; Provisional; Region: PRK10139 768492014157 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 768492014158 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 768492014159 protein binding site [polypeptide binding]; other site 768492014160 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 768492014161 serine endoprotease; Provisional; Region: PRK10898 768492014162 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 768492014163 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 768492014164 protein binding site [polypeptide binding]; other site 768492014165 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 768492014166 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 768492014167 hinge; other site 768492014168 active site 768492014169 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 768492014170 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 768492014171 anti sigma factor interaction site; other site 768492014172 regulatory phosphorylation site [posttranslational modification]; other site 768492014173 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 768492014174 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 768492014175 mce related protein; Region: MCE; pfam02470 768492014176 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 768492014177 conserved hypothetical integral membrane protein; Region: TIGR00056 768492014178 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 768492014179 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 768492014180 Walker A/P-loop; other site 768492014181 ATP binding site [chemical binding]; other site 768492014182 Q-loop/lid; other site 768492014183 ABC transporter signature motif; other site 768492014184 Walker B; other site 768492014185 D-loop; other site 768492014186 H-loop/switch region; other site 768492014187 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 768492014188 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 768492014189 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 768492014190 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 768492014191 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 768492014192 putative active site [active] 768492014193 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 768492014194 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 768492014195 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 768492014196 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 768492014197 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 768492014198 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 768492014199 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 768492014200 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 768492014201 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 768492014202 Walker A/P-loop; other site 768492014203 ATP binding site [chemical binding]; other site 768492014204 Q-loop/lid; other site 768492014205 ABC transporter signature motif; other site 768492014206 Walker B; other site 768492014207 D-loop; other site 768492014208 H-loop/switch region; other site 768492014209 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 768492014210 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 768492014211 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 768492014212 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 768492014213 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 768492014214 30S subunit binding site; other site 768492014215 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 768492014216 active site 768492014217 phosphorylation site [posttranslational modification] 768492014218 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 768492014219 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 768492014220 dimerization domain swap beta strand [polypeptide binding]; other site 768492014221 regulatory protein interface [polypeptide binding]; other site 768492014222 active site 768492014223 regulatory phosphorylation site [posttranslational modification]; other site 768492014224 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 768492014225 HTH domain; Region: HTH_11; pfam08279 768492014226 Mga helix-turn-helix domain; Region: Mga; pfam05043 768492014227 PRD domain; Region: PRD; pfam00874 768492014228 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 768492014229 active site 768492014230 P-loop; other site 768492014231 phosphorylation site [posttranslational modification] 768492014232 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 768492014233 active site 768492014234 phosphorylation site [posttranslational modification] 768492014235 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 768492014236 Protein of unknown function (DUF1341); Region: DUF1341; pfam07071 768492014237 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 768492014238 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768492014239 catalytic residue [active] 768492014240 dihydroorotase; Provisional; Region: PRK09237 768492014241 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 768492014242 active site 768492014243 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 768492014244 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 768492014245 Domain of unknown function (DUF4312); Region: DUF4312; pfam14189 768492014246 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272 768492014247 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 768492014248 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 768492014249 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 768492014250 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 768492014251 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 768492014252 active site 768492014253 cosubstrate binding site; other site 768492014254 substrate binding site [chemical binding]; other site 768492014255 catalytic site [active] 768492014256 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 768492014257 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 768492014258 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768492014259 Helix-turn-helix domain; Region: HTH_18; pfam12833 768492014260 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492014261 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492014262 Cytochrome b562; Region: Cytochrom_B562; cl01546 768492014263 peptidase PmbA; Provisional; Region: PRK11040 768492014264 hypothetical protein; Provisional; Region: PRK05255 768492014265 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 768492014266 RNAase interaction site [polypeptide binding]; other site 768492014267 Barnase, a member of the family of homologous microbial ribonucleases, catalyses the cleavage of single-stranded RNA via a two-step mechanism thought to be similar to that of pancreatic ribonuclease. The mechanism involves a transesterification to give a...; Region: barnase; cd00933 768492014268 active site 768492014269 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 768492014270 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 768492014271 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 768492014272 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768492014273 HlyD family secretion protein; Region: HlyD_3; pfam13437 768492014274 efflux system membrane protein; Provisional; Region: PRK11594 768492014275 transcriptional regulator; Provisional; Region: PRK10632 768492014276 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492014277 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492014278 putative effector binding pocket; other site 768492014279 dimerization interface [polypeptide binding]; other site 768492014280 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 768492014281 active site 768492014282 tetramer interface [polypeptide binding]; other site 768492014283 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 768492014284 haemagglutination activity domain; Region: Haemagg_act; pfam05860 768492014285 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768492014286 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768492014287 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768492014288 MafB19-like deaminase; Region: MafB19-deam; pfam14437 768492014289 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 768492014290 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 768492014291 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 768492014292 protease TldD; Provisional; Region: tldD; PRK10735 768492014293 nitrilase; Region: PLN02798 768492014294 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 768492014295 putative active site [active] 768492014296 catalytic triad [active] 768492014297 dimer interface [polypeptide binding]; other site 768492014298 hypothetical protein; Provisional; Region: PRK10899 768492014299 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 768492014300 ribonuclease G; Provisional; Region: PRK11712 768492014301 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 768492014302 homodimer interface [polypeptide binding]; other site 768492014303 oligonucleotide binding site [chemical binding]; other site 768492014304 Maf-like protein; Region: Maf; pfam02545 768492014305 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 768492014306 active site 768492014307 dimer interface [polypeptide binding]; other site 768492014308 rod shape-determining protein MreD; Provisional; Region: PRK11060 768492014309 rod shape-determining protein MreC; Region: mreC; TIGR00219 768492014310 rod shape-determining protein MreC; Region: MreC; pfam04085 768492014311 rod shape-determining protein MreB; Provisional; Region: PRK13927 768492014312 MreB and similar proteins; Region: MreB_like; cd10225 768492014313 nucleotide binding site [chemical binding]; other site 768492014314 Mg binding site [ion binding]; other site 768492014315 putative protofilament interaction site [polypeptide binding]; other site 768492014316 RodZ interaction site [polypeptide binding]; other site 768492014317 regulatory protein CsrD; Provisional; Region: PRK11059 768492014318 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768492014319 metal binding site [ion binding]; metal-binding site 768492014320 active site 768492014321 I-site; other site 768492014322 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768492014323 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 768492014324 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 768492014325 NADP binding site [chemical binding]; other site 768492014326 dimer interface [polypeptide binding]; other site 768492014327 TMAO/DMSO reductase; Reviewed; Region: PRK05363 768492014328 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 768492014329 Moco binding site; other site 768492014330 metal coordination site [ion binding]; other site 768492014331 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 768492014332 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 768492014333 Dehydroquinase class II; Region: DHquinase_II; pfam01220 768492014334 active site 768492014335 trimer interface [polypeptide binding]; other site 768492014336 dimer interface [polypeptide binding]; other site 768492014337 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 768492014338 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 768492014339 carboxyltransferase (CT) interaction site; other site 768492014340 biotinylation site [posttranslational modification]; other site 768492014341 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 768492014342 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 768492014343 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 768492014344 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 768492014345 hypothetical protein; Provisional; Region: PRK10633 768492014346 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 768492014347 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 768492014348 Na binding site [ion binding]; other site 768492014349 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 768492014350 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 768492014351 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 768492014352 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 768492014353 active site 768492014354 zinc binding site [ion binding]; other site 768492014355 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 768492014356 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 768492014357 FMN binding site [chemical binding]; other site 768492014358 active site 768492014359 catalytic residues [active] 768492014360 substrate binding site [chemical binding]; other site 768492014361 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 768492014362 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 768492014363 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 768492014364 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 768492014365 putative acyl-acceptor binding pocket; other site 768492014366 hypothetical protein; Validated; Region: PRK06186 768492014367 conserved cys residue [active] 768492014368 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 768492014369 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 768492014370 acyl-activating enzyme (AAE) consensus motif; other site 768492014371 AMP binding site [chemical binding]; other site 768492014372 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768492014373 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 768492014374 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 768492014375 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492014376 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492014377 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 768492014378 putative dimerization interface [polypeptide binding]; other site 768492014379 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 768492014380 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 768492014381 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 768492014382 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768492014383 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 768492014384 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 768492014385 putative C-terminal domain interface [polypeptide binding]; other site 768492014386 putative GSH binding site (G-site) [chemical binding]; other site 768492014387 putative dimer interface [polypeptide binding]; other site 768492014388 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 768492014389 putative N-terminal domain interface [polypeptide binding]; other site 768492014390 putative dimer interface [polypeptide binding]; other site 768492014391 putative substrate binding pocket (H-site) [chemical binding]; other site 768492014392 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 768492014393 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492014394 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492014395 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768492014396 putative effector binding pocket; other site 768492014397 dimerization interface [polypeptide binding]; other site 768492014398 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 768492014399 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768492014400 NAD(P) binding site [chemical binding]; other site 768492014401 active site 768492014402 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 768492014403 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 768492014404 dimer interface [polypeptide binding]; other site 768492014405 ssDNA binding site [nucleotide binding]; other site 768492014406 tetramer (dimer of dimers) interface [polypeptide binding]; other site 768492014407 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 768492014408 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 768492014409 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 768492014410 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 768492014411 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 768492014412 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 768492014413 putative NAD(P) binding site [chemical binding]; other site 768492014414 putative substrate binding site [chemical binding]; other site 768492014415 catalytic Zn binding site [ion binding]; other site 768492014416 structural Zn binding site [ion binding]; other site 768492014417 dimer interface [polypeptide binding]; other site 768492014418 maltose O-acetyltransferase; Provisional; Region: PRK10092 768492014419 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 768492014420 active site 768492014421 substrate binding site [chemical binding]; other site 768492014422 trimer interface [polypeptide binding]; other site 768492014423 CoA binding site [chemical binding]; other site 768492014424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 768492014425 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 768492014426 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 768492014427 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768492014428 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492014429 homodimer interface [polypeptide binding]; other site 768492014430 catalytic residue [active] 768492014431 Uncharacterized conserved protein [Function unknown]; Region: COG1284 768492014432 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 768492014433 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768492014434 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 768492014435 putative DNA binding site [nucleotide binding]; other site 768492014436 putative Zn2+ binding site [ion binding]; other site 768492014437 AsnC family; Region: AsnC_trans_reg; pfam01037 768492014438 aromatic amino acid transporter; Provisional; Region: PRK10238 768492014439 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492014440 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768492014441 substrate binding pocket [chemical binding]; other site 768492014442 membrane-bound complex binding site; other site 768492014443 hinge residues; other site 768492014444 alanine racemase; Reviewed; Region: alr; PRK00053 768492014445 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 768492014446 active site 768492014447 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768492014448 substrate binding site [chemical binding]; other site 768492014449 catalytic residues [active] 768492014450 dimer interface [polypeptide binding]; other site 768492014451 replicative DNA helicase; Provisional; Region: PRK08006 768492014452 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 768492014453 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 768492014454 Walker A motif; other site 768492014455 ATP binding site [chemical binding]; other site 768492014456 Walker B motif; other site 768492014457 DNA binding loops [nucleotide binding] 768492014458 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 768492014459 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 768492014460 NADP binding site [chemical binding]; other site 768492014461 dimer interface [polypeptide binding]; other site 768492014462 phage shock protein G; Reviewed; Region: pspG; PRK09459 768492014463 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 768492014464 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 768492014465 FMN binding site [chemical binding]; other site 768492014466 active site 768492014467 catalytic residues [active] 768492014468 substrate binding site [chemical binding]; other site 768492014469 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768492014470 binding surface 768492014471 TPR motif; other site 768492014472 Tetratricopeptide repeat; Region: TPR_16; pfam13432 768492014473 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 768492014474 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768492014475 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768492014476 DNA binding residues [nucleotide binding] 768492014477 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 768492014478 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 768492014479 metal binding site 2 [ion binding]; metal-binding site 768492014480 putative DNA binding helix; other site 768492014481 metal binding site 1 [ion binding]; metal-binding site 768492014482 dimer interface [polypeptide binding]; other site 768492014483 structural Zn2+ binding site [ion binding]; other site 768492014484 hypothetical protein; Provisional; Region: PRK10428 768492014485 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 768492014486 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 768492014487 LexA repressor; Validated; Region: PRK00215 768492014488 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 768492014489 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 768492014490 Catalytic site [active] 768492014491 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 768492014492 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 768492014493 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 768492014494 putative acyl-acceptor binding pocket; other site 768492014495 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 768492014496 UbiA prenyltransferase family; Region: UbiA; pfam01040 768492014497 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 768492014498 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 768492014499 active site 768492014500 maltose regulon periplasmic protein; Provisional; Region: PRK10564 768492014501 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 768492014502 trimer interface; other site 768492014503 sugar binding site [chemical binding]; other site 768492014504 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 768492014505 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 768492014506 Walker A/P-loop; other site 768492014507 ATP binding site [chemical binding]; other site 768492014508 Q-loop/lid; other site 768492014509 ABC transporter signature motif; other site 768492014510 Walker B; other site 768492014511 D-loop; other site 768492014512 H-loop/switch region; other site 768492014513 TOBE domain; Region: TOBE_2; pfam08402 768492014514 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 768492014515 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 768492014516 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 768492014517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492014518 dimer interface [polypeptide binding]; other site 768492014519 conserved gate region; other site 768492014520 putative PBP binding loops; other site 768492014521 ABC-ATPase subunit interface; other site 768492014522 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 768492014523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492014524 dimer interface [polypeptide binding]; other site 768492014525 conserved gate region; other site 768492014526 putative PBP binding loops; other site 768492014527 ABC-ATPase subunit interface; other site 768492014528 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 768492014529 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 768492014530 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 768492014531 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 768492014532 active site 768492014533 dimer interface [polypeptide binding]; other site 768492014534 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 768492014535 dimer interface [polypeptide binding]; other site 768492014536 active site 768492014537 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 768492014538 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 768492014539 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 768492014540 TrkA-N domain; Region: TrkA_N; pfam02254 768492014541 aspartate kinase III; Validated; Region: PRK09084 768492014542 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 768492014543 nucleotide binding site [chemical binding]; other site 768492014544 substrate binding site [chemical binding]; other site 768492014545 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 768492014546 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 768492014547 dimer interface [polypeptide binding]; other site 768492014548 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 768492014549 Sodium Bile acid symporter family; Region: SBF; pfam01758 768492014550 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 768492014551 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 768492014552 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 768492014553 haemagglutination activity domain; Region: Haemagg_act; pfam05860 768492014554 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768492014555 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768492014556 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768492014557 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768492014558 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 768492014559 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 768492014560 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 768492014561 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 768492014562 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768492014563 Walker A/P-loop; other site 768492014564 ATP binding site [chemical binding]; other site 768492014565 Q-loop/lid; other site 768492014566 ABC transporter signature motif; other site 768492014567 Walker B; other site 768492014568 D-loop; other site 768492014569 H-loop/switch region; other site 768492014570 TOBE domain; Region: TOBE_2; pfam08402 768492014571 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 768492014572 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492014573 dimer interface [polypeptide binding]; other site 768492014574 conserved gate region; other site 768492014575 putative PBP binding loops; other site 768492014576 ABC-ATPase subunit interface; other site 768492014577 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 768492014578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492014579 putative PBP binding loops; other site 768492014580 ABC-ATPase subunit interface; other site 768492014581 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 768492014582 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 768492014583 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 768492014584 transcriptional regulator protein; Region: phnR; TIGR03337 768492014585 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492014586 DNA-binding site [nucleotide binding]; DNA binding site 768492014587 UTRA domain; Region: UTRA; pfam07702 768492014588 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 768492014589 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 768492014590 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 768492014591 substrate binding pocket [chemical binding]; other site 768492014592 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 768492014593 B12 binding site [chemical binding]; other site 768492014594 cobalt ligand [ion binding]; other site 768492014595 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 768492014596 transcriptional repressor IclR; Provisional; Region: PRK11569 768492014597 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 768492014598 Bacterial transcriptional regulator; Region: IclR; pfam01614 768492014599 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 768492014600 ATP-binding site [chemical binding]; other site 768492014601 Gluconate-6-phosphate binding site [chemical binding]; other site 768492014602 low affinity gluconate transporter; Provisional; Region: PRK10472 768492014603 GntP family permease; Region: GntP_permease; pfam02447 768492014604 phosphogluconate dehydratase; Validated; Region: PRK09054 768492014605 6-phosphogluconate dehydratase; Region: edd; TIGR01196 768492014606 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 768492014607 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 768492014608 active site 768492014609 intersubunit interface [polypeptide binding]; other site 768492014610 catalytic residue [active] 768492014611 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 768492014612 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 768492014613 isocitrate lyase; Provisional; Region: PRK15063 768492014614 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 768492014615 tetramer interface [polypeptide binding]; other site 768492014616 active site 768492014617 Mg2+/Mn2+ binding site [ion binding]; other site 768492014618 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 768492014619 malate synthase A; Region: malate_syn_A; TIGR01344 768492014620 active site 768492014621 homoserine O-succinyltransferase; Provisional; Region: PRK05368 768492014622 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 768492014623 proposed active site lysine [active] 768492014624 conserved cys residue [active] 768492014625 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 768492014626 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 768492014627 trimer interface [polypeptide binding]; other site 768492014628 putative metal binding site [ion binding]; other site 768492014629 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 768492014630 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 768492014631 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 768492014632 shikimate binding site; other site 768492014633 NAD(P) binding site [chemical binding]; other site 768492014634 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 768492014635 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 768492014636 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 768492014637 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 768492014638 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 768492014639 hypothetical protein; Validated; Region: PRK03430 768492014640 hypothetical protein; Provisional; Region: PRK10736 768492014641 DNA protecting protein DprA; Region: dprA; TIGR00732 768492014642 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 768492014643 active site 768492014644 catalytic residues [active] 768492014645 metal binding site [ion binding]; metal-binding site 768492014646 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 768492014647 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 768492014648 putative active site [active] 768492014649 substrate binding site [chemical binding]; other site 768492014650 putative cosubstrate binding site; other site 768492014651 catalytic site [active] 768492014652 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 768492014653 substrate binding site [chemical binding]; other site 768492014654 16S rRNA methyltransferase B; Provisional; Region: PRK10901 768492014655 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 768492014656 putative RNA binding site [nucleotide binding]; other site 768492014657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492014658 S-adenosylmethionine binding site [chemical binding]; other site 768492014659 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 768492014660 TrkA-N domain; Region: TrkA_N; pfam02254 768492014661 TrkA-C domain; Region: TrkA_C; pfam02080 768492014662 TrkA-N domain; Region: TrkA_N; pfam02254 768492014663 TrkA-C domain; Region: TrkA_C; pfam02080 768492014664 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 768492014665 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 768492014666 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 768492014667 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 768492014668 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 768492014669 DNA binding residues [nucleotide binding] 768492014670 dimer interface [polypeptide binding]; other site 768492014671 metal binding site [ion binding]; metal-binding site 768492014672 hypothetical protein; Provisional; Region: PRK10203 768492014673 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 768492014674 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 768492014675 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 768492014676 alphaNTD homodimer interface [polypeptide binding]; other site 768492014677 alphaNTD - beta interaction site [polypeptide binding]; other site 768492014678 alphaNTD - beta' interaction site [polypeptide binding]; other site 768492014679 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 768492014680 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 768492014681 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 768492014682 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768492014683 RNA binding surface [nucleotide binding]; other site 768492014684 30S ribosomal protein S11; Validated; Region: PRK05309 768492014685 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 768492014686 30S ribosomal protein S13; Region: bact_S13; TIGR03631 768492014687 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 768492014688 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 768492014689 SecY translocase; Region: SecY; pfam00344 768492014690 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 768492014691 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 768492014692 23S rRNA binding site [nucleotide binding]; other site 768492014693 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 768492014694 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 768492014695 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 768492014696 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 768492014697 5S rRNA interface [nucleotide binding]; other site 768492014698 23S rRNA interface [nucleotide binding]; other site 768492014699 L5 interface [polypeptide binding]; other site 768492014700 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 768492014701 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 768492014702 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 768492014703 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 768492014704 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 768492014705 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 768492014706 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 768492014707 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 768492014708 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 768492014709 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 768492014710 RNA binding site [nucleotide binding]; other site 768492014711 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 768492014712 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 768492014713 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 768492014714 23S rRNA interface [nucleotide binding]; other site 768492014715 putative translocon interaction site; other site 768492014716 signal recognition particle (SRP54) interaction site; other site 768492014717 L23 interface [polypeptide binding]; other site 768492014718 trigger factor interaction site; other site 768492014719 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 768492014720 23S rRNA interface [nucleotide binding]; other site 768492014721 5S rRNA interface [nucleotide binding]; other site 768492014722 putative antibiotic binding site [chemical binding]; other site 768492014723 L25 interface [polypeptide binding]; other site 768492014724 L27 interface [polypeptide binding]; other site 768492014725 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 768492014726 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 768492014727 G-X-X-G motif; other site 768492014728 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 768492014729 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 768492014730 protein-rRNA interface [nucleotide binding]; other site 768492014731 putative translocon binding site; other site 768492014732 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 768492014733 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 768492014734 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 768492014735 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 768492014736 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 768492014737 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 768492014738 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 768492014739 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 768492014740 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 768492014741 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 768492014742 heme binding site [chemical binding]; other site 768492014743 ferroxidase pore; other site 768492014744 ferroxidase diiron center [ion binding]; other site 768492014745 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 768492014746 elongation factor Tu; Reviewed; Region: PRK00049 768492014747 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 768492014748 G1 box; other site 768492014749 GEF interaction site [polypeptide binding]; other site 768492014750 GTP/Mg2+ binding site [chemical binding]; other site 768492014751 Switch I region; other site 768492014752 G2 box; other site 768492014753 G3 box; other site 768492014754 Switch II region; other site 768492014755 G4 box; other site 768492014756 G5 box; other site 768492014757 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 768492014758 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 768492014759 Antibiotic Binding Site [chemical binding]; other site 768492014760 elongation factor G; Reviewed; Region: PRK00007 768492014761 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 768492014762 G1 box; other site 768492014763 putative GEF interaction site [polypeptide binding]; other site 768492014764 GTP/Mg2+ binding site [chemical binding]; other site 768492014765 Switch I region; other site 768492014766 G2 box; other site 768492014767 G3 box; other site 768492014768 Switch II region; other site 768492014769 G4 box; other site 768492014770 G5 box; other site 768492014771 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 768492014772 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 768492014773 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 768492014774 30S ribosomal protein S7; Validated; Region: PRK05302 768492014775 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 768492014776 S17 interaction site [polypeptide binding]; other site 768492014777 S8 interaction site; other site 768492014778 16S rRNA interaction site [nucleotide binding]; other site 768492014779 streptomycin interaction site [chemical binding]; other site 768492014780 23S rRNA interaction site [nucleotide binding]; other site 768492014781 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 768492014782 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 768492014783 sulfur relay protein TusC; Validated; Region: PRK00211 768492014784 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 768492014785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 768492014786 YheO-like PAS domain; Region: PAS_6; pfam08348 768492014787 HTH domain; Region: HTH_22; pfam13309 768492014788 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 768492014789 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 768492014790 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 768492014791 phi X174 lysis protein; Provisional; Region: PRK02793 768492014792 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737 768492014793 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 768492014794 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 768492014795 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 768492014796 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 768492014797 TrkA-N domain; Region: TrkA_N; pfam02254 768492014798 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 768492014799 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 768492014800 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768492014801 Walker A/P-loop; other site 768492014802 ATP binding site [chemical binding]; other site 768492014803 Q-loop/lid; other site 768492014804 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768492014805 ABC transporter; Region: ABC_tran_2; pfam12848 768492014806 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768492014807 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 768492014808 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 768492014809 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 768492014810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492014811 dimer interface [polypeptide binding]; other site 768492014812 conserved gate region; other site 768492014813 putative PBP binding loops; other site 768492014814 ABC-ATPase subunit interface; other site 768492014815 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 768492014816 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 768492014817 Walker A/P-loop; other site 768492014818 ATP binding site [chemical binding]; other site 768492014819 Q-loop/lid; other site 768492014820 ABC transporter signature motif; other site 768492014821 Walker B; other site 768492014822 D-loop; other site 768492014823 H-loop/switch region; other site 768492014824 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 768492014825 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492014826 substrate binding pocket [chemical binding]; other site 768492014827 membrane-bound complex binding site; other site 768492014828 hinge residues; other site 768492014829 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 768492014830 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 768492014831 putative hydrolase; Provisional; Region: PRK10985 768492014832 hypothetical protein; Provisional; Region: PRK04966 768492014833 phosphoribulokinase; Provisional; Region: PRK15453 768492014834 hypothetical protein; Provisional; Region: PRK10738 768492014835 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 768492014836 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 768492014837 ligand binding site [chemical binding]; other site 768492014838 flexible hinge region; other site 768492014839 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 768492014840 putative switch regulator; other site 768492014841 non-specific DNA interactions [nucleotide binding]; other site 768492014842 DNA binding site [nucleotide binding] 768492014843 sequence specific DNA binding site [nucleotide binding]; other site 768492014844 putative cAMP binding site [chemical binding]; other site 768492014845 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 768492014846 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 768492014847 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 768492014848 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 768492014849 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768492014850 inhibitor-cofactor binding pocket; inhibition site 768492014851 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492014852 catalytic residue [active] 768492014853 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 768492014854 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 768492014855 glutamine binding [chemical binding]; other site 768492014856 catalytic triad [active] 768492014857 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 768492014858 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 768492014859 Walker A motif; other site 768492014860 ATP binding site [chemical binding]; other site 768492014861 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 768492014862 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 768492014863 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492014864 active site 768492014865 phosphorylation site [posttranslational modification] 768492014866 intermolecular recognition site; other site 768492014867 dimerization interface [polypeptide binding]; other site 768492014868 LytTr DNA-binding domain; Region: LytTR; pfam04397 768492014869 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 768492014870 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 768492014871 GAF domain; Region: GAF; pfam01590 768492014872 Histidine kinase; Region: His_kinase; pfam06580 768492014873 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492014874 ATP binding site [chemical binding]; other site 768492014875 Mg2+ binding site [ion binding]; other site 768492014876 G-X-G motif; other site 768492014877 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 768492014878 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 768492014879 active site 768492014880 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 768492014881 active site 768492014882 methionine cluster; other site 768492014883 phosphorylation site [posttranslational modification] 768492014884 metal binding site [ion binding]; metal-binding site 768492014885 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 768492014886 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 768492014887 NAD binding site [chemical binding]; other site 768492014888 sugar binding site [chemical binding]; other site 768492014889 divalent metal binding site [ion binding]; other site 768492014890 tetramer (dimer of dimers) interface [polypeptide binding]; other site 768492014891 dimer interface [polypeptide binding]; other site 768492014892 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768492014893 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492014894 DNA binding site [nucleotide binding] 768492014895 domain linker motif; other site 768492014896 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 768492014897 dimerization interface (closed form) [polypeptide binding]; other site 768492014898 ligand binding site [chemical binding]; other site 768492014899 putative transporter; Provisional; Region: PRK03699 768492014900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492014901 putative substrate translocation pore; other site 768492014902 cytosine deaminase; Provisional; Region: PRK09230 768492014903 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 768492014904 active site 768492014905 nitrite reductase subunit NirD; Provisional; Region: PRK14989 768492014906 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768492014907 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 768492014908 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 768492014909 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 768492014910 nitrite transporter NirC; Provisional; Region: PRK11562 768492014911 siroheme synthase; Provisional; Region: cysG; PRK10637 768492014912 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 768492014913 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 768492014914 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 768492014915 active site 768492014916 SAM binding site [chemical binding]; other site 768492014917 homodimer interface [polypeptide binding]; other site 768492014918 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 768492014919 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 768492014920 active site 768492014921 HIGH motif; other site 768492014922 dimer interface [polypeptide binding]; other site 768492014923 KMSKS motif; other site 768492014924 phosphoglycolate phosphatase; Provisional; Region: PRK13222 768492014925 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 768492014926 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492014927 motif II; other site 768492014928 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 768492014929 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 768492014930 substrate binding site [chemical binding]; other site 768492014931 hexamer interface [polypeptide binding]; other site 768492014932 metal binding site [ion binding]; metal-binding site 768492014933 DNA adenine methylase; Provisional; Region: PRK10904 768492014934 hypothetical protein; Reviewed; Region: PRK11901 768492014935 cell division protein DamX; Validated; Region: PRK10905 768492014936 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 768492014937 active site 768492014938 dimer interface [polypeptide binding]; other site 768492014939 metal binding site [ion binding]; metal-binding site 768492014940 shikimate kinase; Reviewed; Region: aroK; PRK00131 768492014941 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 768492014942 ADP binding site [chemical binding]; other site 768492014943 magnesium binding site [ion binding]; other site 768492014944 putative shikimate binding site; other site 768492014945 putative outer membrane porin HofQ; Provisional; Region: hofQ; PRK13568 768492014946 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 768492014947 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 768492014948 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 768492014949 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 768492014950 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 768492014951 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 768492014952 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 768492014953 Transglycosylase; Region: Transgly; pfam00912 768492014954 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 768492014955 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 768492014956 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 768492014957 ADP-ribose binding site [chemical binding]; other site 768492014958 dimer interface [polypeptide binding]; other site 768492014959 active site 768492014960 nudix motif; other site 768492014961 metal binding site [ion binding]; metal-binding site 768492014962 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 768492014963 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 768492014964 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492014965 motif II; other site 768492014966 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768492014967 RNA binding surface [nucleotide binding]; other site 768492014968 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 768492014969 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 768492014970 dimerization interface [polypeptide binding]; other site 768492014971 domain crossover interface; other site 768492014972 redox-dependent activation switch; other site 768492014973 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 768492014974 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 768492014975 active site 768492014976 substrate-binding site [chemical binding]; other site 768492014977 metal-binding site [ion binding] 768492014978 ATP binding site [chemical binding]; other site 768492014979 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 768492014980 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 768492014981 oligomeric interface; other site 768492014982 putative active site [active] 768492014983 homodimer interface [polypeptide binding]; other site 768492014984 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 768492014985 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768492014986 dimerization interface [polypeptide binding]; other site 768492014987 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492014988 dimer interface [polypeptide binding]; other site 768492014989 phosphorylation site [posttranslational modification] 768492014990 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492014991 ATP binding site [chemical binding]; other site 768492014992 G-X-G motif; other site 768492014993 osmolarity response regulator; Provisional; Region: ompR; PRK09468 768492014994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492014995 active site 768492014996 phosphorylation site [posttranslational modification] 768492014997 intermolecular recognition site; other site 768492014998 dimerization interface [polypeptide binding]; other site 768492014999 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768492015000 DNA binding site [nucleotide binding] 768492015001 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 768492015002 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 768492015003 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 768492015004 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 768492015005 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 768492015006 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 768492015007 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 768492015008 RNA binding site [nucleotide binding]; other site 768492015009 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 768492015010 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 768492015011 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 768492015012 G1 box; other site 768492015013 GTP/Mg2+ binding site [chemical binding]; other site 768492015014 Switch I region; other site 768492015015 G2 box; other site 768492015016 G3 box; other site 768492015017 Switch II region; other site 768492015018 G4 box; other site 768492015019 G5 box; other site 768492015020 Nucleoside recognition; Region: Gate; pfam07670 768492015021 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 768492015022 Nucleoside recognition; Region: Gate; pfam07670 768492015023 FeoC like transcriptional regulator; Region: FeoC; cl17677 768492015024 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 768492015025 carboxylesterase BioH; Provisional; Region: PRK10349 768492015026 DNA utilization protein GntX; Provisional; Region: PRK11595 768492015027 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768492015028 active site 768492015029 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 768492015030 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 768492015031 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 768492015032 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 768492015033 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 768492015034 maltodextrin phosphorylase; Provisional; Region: PRK14985 768492015035 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 768492015036 active site pocket [active] 768492015037 transcriptional regulator MalT; Provisional; Region: PRK04841 768492015038 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492015039 DNA binding residues [nucleotide binding] 768492015040 dimerization interface [polypeptide binding]; other site 768492015041 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 768492015042 active site residue [active] 768492015043 D-galactonate transporter; Region: 2A0114; TIGR00893 768492015044 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492015045 putative substrate translocation pore; other site 768492015046 Domain of unknown function (DUF386); Region: DUF386; cl01047 768492015047 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 768492015048 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 768492015049 inhibitor site; inhibition site 768492015050 active site 768492015051 dimer interface [polypeptide binding]; other site 768492015052 catalytic residue [active] 768492015053 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 768492015054 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 768492015055 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 768492015056 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768492015057 substrate binding site [chemical binding]; other site 768492015058 dimer interface [polypeptide binding]; other site 768492015059 ATP binding site [chemical binding]; other site 768492015060 intramembrane serine protease GlpG; Provisional; Region: PRK10907 768492015061 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 768492015062 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 768492015063 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 768492015064 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 768492015065 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 768492015066 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 768492015067 glycogen phosphorylase; Provisional; Region: PRK14986 768492015068 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 768492015069 homodimer interface [polypeptide binding]; other site 768492015070 active site pocket [active] 768492015071 glycogen synthase; Provisional; Region: glgA; PRK00654 768492015072 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 768492015073 ADP-binding pocket [chemical binding]; other site 768492015074 homodimer interface [polypeptide binding]; other site 768492015075 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 768492015076 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 768492015077 ligand binding site; other site 768492015078 oligomer interface; other site 768492015079 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 768492015080 sulfate 1 binding site; other site 768492015081 glycogen debranching enzyme; Provisional; Region: PRK03705 768492015082 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 768492015083 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 768492015084 active site 768492015085 catalytic site [active] 768492015086 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 768492015087 glycogen branching enzyme; Provisional; Region: PRK05402 768492015088 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 768492015089 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 768492015090 active site 768492015091 catalytic site [active] 768492015092 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 768492015093 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 768492015094 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 768492015095 putative antibiotic transporter; Provisional; Region: PRK10739 768492015096 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 768492015097 ATP-binding site [chemical binding]; other site 768492015098 Gluconate-6-phosphate binding site [chemical binding]; other site 768492015099 high-affinity gluconate transporter; Provisional; Region: PRK14984 768492015100 gluconate transporter; Region: gntP; TIGR00791 768492015101 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 768492015102 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492015103 DNA binding site [nucleotide binding] 768492015104 domain linker motif; other site 768492015105 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 768492015106 putative ligand binding site [chemical binding]; other site 768492015107 putative dimerization interface [polypeptide binding]; other site 768492015108 Pirin-related protein [General function prediction only]; Region: COG1741 768492015109 Pirin; Region: Pirin; pfam02678 768492015110 putative acetyltransferase YhhY; Provisional; Region: PRK10140 768492015111 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492015112 Coenzyme A binding pocket [chemical binding]; other site 768492015113 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 768492015114 putative active site pocket [active] 768492015115 cleavage site 768492015116 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 768492015117 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 768492015118 Metal-binding active site; metal-binding site 768492015119 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 768492015120 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768492015121 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768492015122 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 768492015123 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 768492015124 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768492015125 PYR/PP interface [polypeptide binding]; other site 768492015126 dimer interface [polypeptide binding]; other site 768492015127 TPP binding site [chemical binding]; other site 768492015128 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768492015129 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 768492015130 TPP-binding site; other site 768492015131 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768492015132 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 768492015133 substrate binding site [chemical binding]; other site 768492015134 ATP binding site [chemical binding]; other site 768492015135 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 768492015136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 768492015137 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 768492015138 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768492015139 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768492015140 putative active site [active] 768492015141 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 768492015142 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 768492015143 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 768492015144 tetrameric interface [polypeptide binding]; other site 768492015145 NAD binding site [chemical binding]; other site 768492015146 catalytic residues [active] 768492015147 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 768492015148 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492015149 putative substrate translocation pore; other site 768492015150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492015151 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 768492015152 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 768492015153 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 768492015154 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768492015155 Walker A/P-loop; other site 768492015156 ATP binding site [chemical binding]; other site 768492015157 Q-loop/lid; other site 768492015158 ABC transporter signature motif; other site 768492015159 Walker B; other site 768492015160 D-loop; other site 768492015161 H-loop/switch region; other site 768492015162 FaeA-like protein; Region: FaeA; pfam04703 768492015163 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 768492015164 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 768492015165 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 768492015166 Fimbrial protein; Region: Fimbrial; cl01416 768492015167 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 768492015168 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 768492015169 PapC N-terminal domain; Region: PapC_N; pfam13954 768492015170 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 768492015171 PapC C-terminal domain; Region: PapC_C; pfam13953 768492015172 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 768492015173 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 768492015174 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 768492015175 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 768492015176 Fimbrial protein; Region: Fimbrial; cl01416 768492015177 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 768492015178 O-Antigen ligase; Region: Wzy_C; pfam04932 768492015179 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 768492015180 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768492015181 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492015182 DNA binding residues [nucleotide binding] 768492015183 dimerization interface [polypeptide binding]; other site 768492015184 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 768492015185 Amidinotransferase; Region: Amidinotransf; pfam02274 768492015186 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768492015187 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768492015188 putative DNA binding site [nucleotide binding]; other site 768492015189 putative Zn2+ binding site [ion binding]; other site 768492015190 AsnC family; Region: AsnC_trans_reg; pfam01037 768492015191 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 768492015192 active site 768492015193 Mn binding site [ion binding]; other site 768492015194 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502 768492015195 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 768492015196 Protein of unknown function (DUF330); Region: DUF330; pfam03886 768492015197 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 768492015198 mce related protein; Region: MCE; pfam02470 768492015199 mce related protein; Region: MCE; pfam02470 768492015200 mce related protein; Region: MCE; pfam02470 768492015201 Paraquat-inducible protein A; Region: PqiA; pfam04403 768492015202 Paraquat-inducible protein A; Region: PqiA; pfam04403 768492015203 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 768492015204 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492015205 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768492015206 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 768492015207 Predicted flavoproteins [General function prediction only]; Region: COG2081 768492015208 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 768492015209 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 768492015210 universal stress protein UspB; Provisional; Region: PRK04960 768492015211 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 768492015212 Ligand Binding Site [chemical binding]; other site 768492015213 glutamate dehydrogenase; Provisional; Region: PRK09414 768492015214 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 768492015215 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 768492015216 NAD(P) binding site [chemical binding]; other site 768492015217 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 768492015218 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 768492015219 ligand binding site [chemical binding]; other site 768492015220 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 768492015221 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768492015222 Walker A/P-loop; other site 768492015223 ATP binding site [chemical binding]; other site 768492015224 Q-loop/lid; other site 768492015225 ABC transporter signature motif; other site 768492015226 Walker B; other site 768492015227 D-loop; other site 768492015228 H-loop/switch region; other site 768492015229 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768492015230 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768492015231 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768492015232 TM-ABC transporter signature motif; other site 768492015233 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768492015234 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768492015235 TM-ABC transporter signature motif; other site 768492015236 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 768492015237 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 768492015238 N- and C-terminal domain interface [polypeptide binding]; other site 768492015239 active site 768492015240 MgATP binding site [chemical binding]; other site 768492015241 catalytic site [active] 768492015242 metal binding site [ion binding]; metal-binding site 768492015243 carbohydrate binding site [chemical binding]; other site 768492015244 putative homodimer interface [polypeptide binding]; other site 768492015245 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 768492015246 putative active site [active] 768492015247 putative methyltransferase; Provisional; Region: PRK10742 768492015248 oligopeptidase A; Provisional; Region: PRK10911 768492015249 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 768492015250 active site 768492015251 Zn binding site [ion binding]; other site 768492015252 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 768492015253 nucleotide binding site/active site [active] 768492015254 HIT family signature motif; other site 768492015255 catalytic residue [active] 768492015256 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 768492015257 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 768492015258 glutathione reductase; Validated; Region: PRK06116 768492015259 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768492015260 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768492015261 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768492015262 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 768492015263 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 768492015264 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 768492015265 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 768492015266 haemagglutination activity domain; Region: Haemagg_act; pfam05860 768492015267 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768492015268 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768492015269 DNA binding residues [nucleotide binding] 768492015270 dimerization interface [polypeptide binding]; other site 768492015271 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 768492015272 O-Antigen ligase; Region: Wzy_C; pfam04932 768492015273 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 768492015274 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 768492015275 Fimbrial protein; Region: Fimbrial; pfam00419 768492015276 Fimbrial protein; Region: Fimbrial; pfam00419 768492015277 Fimbrial protein; Region: Fimbrial; cl01416 768492015278 fimbrial assembly chaperone StbE; Provisional; Region: PRK15246 768492015279 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 768492015280 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 768492015281 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 768492015282 PapC N-terminal domain; Region: PapC_N; pfam13954 768492015283 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 768492015284 PapC C-terminal domain; Region: PapC_C; pfam13953 768492015285 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 768492015286 Fimbrial protein; Region: Fimbrial; cl01416 768492015287 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 768492015288 DNA binding site [nucleotide binding] 768492015289 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 768492015290 DNA binding site [nucleotide binding] 768492015291 haemagglutination activity domain; Region: Haemagg_act; pfam05860 768492015292 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 768492015293 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 768492015294 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 768492015295 DinB family; Region: DinB; cl17821 768492015296 DinB superfamily; Region: DinB_2; pfam12867 768492015297 Cupin; Region: Cupin_6; pfam12852 768492015298 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492015299 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768492015300 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492015301 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 768492015302 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768492015303 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492015304 dimer interface [polypeptide binding]; other site 768492015305 phosphorylation site [posttranslational modification] 768492015306 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492015307 ATP binding site [chemical binding]; other site 768492015308 Mg2+ binding site [ion binding]; other site 768492015309 G-X-G motif; other site 768492015310 Response regulator receiver domain; Region: Response_reg; pfam00072 768492015311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492015312 active site 768492015313 phosphorylation site [posttranslational modification] 768492015314 intermolecular recognition site; other site 768492015315 dimerization interface [polypeptide binding]; other site 768492015316 BetR domain; Region: BetR; pfam08667 768492015317 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 768492015318 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 768492015319 active site 768492015320 phosphorylation site [posttranslational modification] 768492015321 intermolecular recognition site; other site 768492015322 dimerization interface [polypeptide binding]; other site 768492015323 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 768492015324 catalytic triad [active] 768492015325 putative active site [active] 768492015326 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 768492015327 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 768492015328 Autotransporter beta-domain; Region: Autotransporter; pfam03797 768492015329 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 768492015330 catalytic triad [active] 768492015331 putative active site [active] 768492015332 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 768492015333 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 768492015334 Autotransporter beta-domain; Region: Autotransporter; pfam03797 768492015335 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768492015336 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768492015337 hypothetical protein; Provisional; Region: PRK02399 768492015338 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 768492015339 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 768492015340 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 768492015341 dimer interface [polypeptide binding]; other site 768492015342 RNase II stability modulator; Provisional; Region: PRK10060 768492015343 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768492015344 putative active site [active] 768492015345 heme pocket [chemical binding]; other site 768492015346 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768492015347 metal binding site [ion binding]; metal-binding site 768492015348 active site 768492015349 I-site; other site 768492015350 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768492015351 enoyl-CoA hydratase; Validated; Region: PRK08788 768492015352 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768492015353 substrate binding site [chemical binding]; other site 768492015354 oxyanion hole (OAH) forming residues; other site 768492015355 trimer interface [polypeptide binding]; other site 768492015356 inner membrane protein YhjD; Region: TIGR00766 768492015357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492015358 metabolite-proton symporter; Region: 2A0106; TIGR00883 768492015359 putative substrate translocation pore; other site 768492015360 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 768492015361 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 768492015362 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 768492015363 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768492015364 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 768492015365 active site 1 [active] 768492015366 dimer interface [polypeptide binding]; other site 768492015367 hexamer interface [polypeptide binding]; other site 768492015368 active site 2 [active] 768492015369 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768492015370 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 768492015371 substrate binding site [chemical binding]; other site 768492015372 ATP binding site [chemical binding]; other site 768492015373 ketol-acid reductoisomerase; Validated; Region: PRK05225 768492015374 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 768492015375 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 768492015376 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 768492015377 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492015378 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 768492015379 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 768492015380 putative dimerization interface [polypeptide binding]; other site 768492015381 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 768492015382 threonine dehydratase; Reviewed; Region: PRK09224 768492015383 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 768492015384 tetramer interface [polypeptide binding]; other site 768492015385 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492015386 catalytic residue [active] 768492015387 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 768492015388 putative Ile/Val binding site [chemical binding]; other site 768492015389 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 768492015390 putative Ile/Val binding site [chemical binding]; other site 768492015391 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 768492015392 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 768492015393 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 768492015394 homodimer interface [polypeptide binding]; other site 768492015395 substrate-cofactor binding pocket; other site 768492015396 catalytic residue [active] 768492015397 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 768492015398 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 768492015399 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768492015400 PYR/PP interface [polypeptide binding]; other site 768492015401 dimer interface [polypeptide binding]; other site 768492015402 TPP binding site [chemical binding]; other site 768492015403 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768492015404 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 768492015405 TPP-binding site [chemical binding]; other site 768492015406 dimer interface [polypeptide binding]; other site 768492015407 ilvG operon leader peptide; Provisional; Region: PRK10424 768492015408 putative sialic acid transporter; Region: 2A0112; TIGR00891 768492015409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492015410 putative substrate translocation pore; other site 768492015411 putative ATP-dependent protease; Provisional; Region: PRK09862 768492015412 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 768492015413 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492015414 Walker A motif; other site 768492015415 ATP binding site [chemical binding]; other site 768492015416 Walker B motif; other site 768492015417 arginine finger; other site 768492015418 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 768492015419 hypothetical protein; Provisional; Region: PRK11027 768492015420 transcriptional regulator HdfR; Provisional; Region: PRK03601 768492015421 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492015422 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768492015423 dimerization interface [polypeptide binding]; other site 768492015424 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768492015425 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768492015426 TM-ABC transporter signature motif; other site 768492015427 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768492015428 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768492015429 TM-ABC transporter signature motif; other site 768492015430 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 768492015431 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768492015432 Walker A/P-loop; other site 768492015433 ATP binding site [chemical binding]; other site 768492015434 Q-loop/lid; other site 768492015435 ABC transporter signature motif; other site 768492015436 Walker B; other site 768492015437 D-loop; other site 768492015438 H-loop/switch region; other site 768492015439 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768492015440 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 768492015441 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 768492015442 putative ligand binding site [chemical binding]; other site 768492015443 glutamate racemase; Provisional; Region: PRK00865 768492015444 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 768492015445 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768492015446 N-terminal plug; other site 768492015447 ligand-binding site [chemical binding]; other site 768492015448 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 768492015449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492015450 S-adenosylmethionine binding site [chemical binding]; other site 768492015451 hypothetical protein; Provisional; Region: PRK11056 768492015452 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 768492015453 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768492015454 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 768492015455 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768492015456 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768492015457 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 768492015458 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492015459 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 768492015460 dimerization interface [polypeptide binding]; other site 768492015461 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 768492015462 catalytic triad [active] 768492015463 dimer interface [polypeptide binding]; other site 768492015464 Glutaredoxin (GRX) family, PRX5 hybrid subfamily; composed of hybrid proteins containing peroxiredoxin (PRX) and GRX domains, which is found in some pathogenic bacteria and cyanobacteria. PRXs are thiol-specific antioxidant (TSA) proteins that confer a...; Region: GRX_hybridPRX5; cd03029 768492015465 GSH binding site [chemical binding]; other site 768492015466 catalytic residues [active] 768492015467 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 768492015468 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768492015469 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768492015470 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768492015471 argininosuccinate lyase; Provisional; Region: PRK04833 768492015472 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 768492015473 active sites [active] 768492015474 tetramer interface [polypeptide binding]; other site 768492015475 argininosuccinate synthase; Provisional; Region: PRK13820 768492015476 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 768492015477 ANP binding site [chemical binding]; other site 768492015478 Substrate Binding Site II [chemical binding]; other site 768492015479 Substrate Binding Site I [chemical binding]; other site 768492015480 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 768492015481 nucleotide binding site [chemical binding]; other site 768492015482 N-acetyl-L-glutamate binding site [chemical binding]; other site 768492015483 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 768492015484 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 768492015485 acetylornithine deacetylase; Provisional; Region: PRK05111 768492015486 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 768492015487 metal binding site [ion binding]; metal-binding site 768492015488 putative dimer interface [polypeptide binding]; other site 768492015489 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 768492015490 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 768492015491 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768492015492 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492015493 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768492015494 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768492015495 LysE type translocator; Region: LysE; pfam01810 768492015496 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 768492015497 FAD binding site [chemical binding]; other site 768492015498 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 768492015499 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 768492015500 putative catalytic residues [active] 768492015501 putative nucleotide binding site [chemical binding]; other site 768492015502 putative aspartate binding site [chemical binding]; other site 768492015503 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 768492015504 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 768492015505 cystathionine gamma-synthase; Provisional; Region: PRK08045 768492015506 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 768492015507 homodimer interface [polypeptide binding]; other site 768492015508 substrate-cofactor binding pocket; other site 768492015509 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492015510 catalytic residue [active] 768492015511 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 768492015512 dimerization interface [polypeptide binding]; other site 768492015513 DNA binding site [nucleotide binding] 768492015514 corepressor binding sites; other site 768492015515 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 768492015516 primosome assembly protein PriA; Validated; Region: PRK05580 768492015517 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768492015518 ATP binding site [chemical binding]; other site 768492015519 putative Mg++ binding site [ion binding]; other site 768492015520 DAN domain; Region: DAN; cl17734 768492015521 helicase superfamily c-terminal domain; Region: HELICc; smart00490 768492015522 ATP-binding site [chemical binding]; other site 768492015523 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492015524 DNA binding site [nucleotide binding] 768492015525 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 768492015526 domain linker motif; other site 768492015527 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 768492015528 dimerization interface [polypeptide binding]; other site 768492015529 ligand binding site [chemical binding]; other site 768492015530 Sporulation related domain; Region: SPOR; cl10051 768492015531 cell division protein FtsN; Provisional; Region: PRK12757 768492015532 Sporulation related domain; Region: SPOR; cl10051 768492015533 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 768492015534 active site 768492015535 HslU subunit interaction site [polypeptide binding]; other site 768492015536 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 768492015537 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492015538 Walker A motif; other site 768492015539 ATP binding site [chemical binding]; other site 768492015540 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 768492015541 Walker B motif; other site 768492015542 arginine finger; other site 768492015543 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 768492015544 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 768492015545 UbiA prenyltransferase family; Region: UbiA; pfam01040 768492015546 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 768492015547 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3074 768492015548 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 768492015549 amphipathic channel; other site 768492015550 Asn-Pro-Ala signature motifs; other site 768492015551 glycerol kinase; Provisional; Region: glpK; PRK00047 768492015552 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 768492015553 N- and C-terminal domain interface [polypeptide binding]; other site 768492015554 active site 768492015555 MgATP binding site [chemical binding]; other site 768492015556 catalytic site [active] 768492015557 metal binding site [ion binding]; metal-binding site 768492015558 glycerol binding site [chemical binding]; other site 768492015559 homotetramer interface [polypeptide binding]; other site 768492015560 homodimer interface [polypeptide binding]; other site 768492015561 FBP binding site [chemical binding]; other site 768492015562 protein IIAGlc interface [polypeptide binding]; other site 768492015563 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 768492015564 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 768492015565 putative active site [active] 768492015566 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 768492015567 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492015568 putative substrate translocation pore; other site 768492015569 Predicted transcriptional regulator [Transcription]; Region: COG2345 768492015570 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 768492015571 ferredoxin-NADP reductase; Provisional; Region: PRK10926 768492015572 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 768492015573 FAD binding pocket [chemical binding]; other site 768492015574 FAD binding motif [chemical binding]; other site 768492015575 phosphate binding motif [ion binding]; other site 768492015576 beta-alpha-beta structure motif; other site 768492015577 NAD binding pocket [chemical binding]; other site 768492015578 Predicted membrane protein [Function unknown]; Region: COG3152 768492015579 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 768492015580 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 768492015581 triosephosphate isomerase; Provisional; Region: PRK14567 768492015582 substrate binding site [chemical binding]; other site 768492015583 dimer interface [polypeptide binding]; other site 768492015584 catalytic triad [active] 768492015585 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492015586 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 768492015587 substrate binding pocket [chemical binding]; other site 768492015588 membrane-bound complex binding site; other site 768492015589 hinge residues; other site 768492015590 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 768492015591 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 768492015592 active site 768492015593 ADP/pyrophosphate binding site [chemical binding]; other site 768492015594 dimerization interface [polypeptide binding]; other site 768492015595 allosteric effector site; other site 768492015596 fructose-1,6-bisphosphate binding site; other site 768492015597 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 768492015598 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 768492015599 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 768492015600 dimer interface [polypeptide binding]; other site 768492015601 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 768492015602 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492015603 active site 768492015604 phosphorylation site [posttranslational modification] 768492015605 intermolecular recognition site; other site 768492015606 dimerization interface [polypeptide binding]; other site 768492015607 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768492015608 DNA binding site [nucleotide binding] 768492015609 two-component sensor protein; Provisional; Region: cpxA; PRK09470 768492015610 HAMP domain; Region: HAMP; pfam00672 768492015611 dimerization interface [polypeptide binding]; other site 768492015612 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492015613 dimer interface [polypeptide binding]; other site 768492015614 phosphorylation site [posttranslational modification] 768492015615 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492015616 ATP binding site [chemical binding]; other site 768492015617 Mg2+ binding site [ion binding]; other site 768492015618 G-X-G motif; other site 768492015619 putative rRNA methylase; Provisional; Region: PRK10358 768492015620 CHAD domain; Region: CHAD; pfam05235 768492015621 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 768492015622 serine acetyltransferase; Provisional; Region: cysE; PRK11132 768492015623 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 768492015624 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 768492015625 trimer interface [polypeptide binding]; other site 768492015626 active site 768492015627 substrate binding site [chemical binding]; other site 768492015628 CoA binding site [chemical binding]; other site 768492015629 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 768492015630 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 768492015631 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 768492015632 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 768492015633 SecA binding site; other site 768492015634 Preprotein binding site; other site 768492015635 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 768492015636 GSH binding site [chemical binding]; other site 768492015637 catalytic residues [active] 768492015638 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 768492015639 active site residue [active] 768492015640 phosphoglyceromutase; Provisional; Region: PRK05434 768492015641 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 768492015642 AmiB activator; Provisional; Region: PRK11637 768492015643 Peptidase family M23; Region: Peptidase_M23; pfam01551 768492015644 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 768492015645 NodB motif; other site 768492015646 putative active site [active] 768492015647 putative catalytic site [active] 768492015648 Zn binding site [ion binding]; other site 768492015649 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 768492015650 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 768492015651 NAD(P) binding site [chemical binding]; other site 768492015652 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 768492015653 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 768492015654 substrate-cofactor binding pocket; other site 768492015655 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768492015656 catalytic residue [active] 768492015657 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 768492015658 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 768492015659 NADP binding site [chemical binding]; other site 768492015660 homopentamer interface [polypeptide binding]; other site 768492015661 substrate binding site [chemical binding]; other site 768492015662 active site 768492015663 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 768492015664 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 768492015665 putative active site [active] 768492015666 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 768492015667 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 768492015668 putative active site [active] 768492015669 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768492015670 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 768492015671 putative glycosyl transferase; Provisional; Region: PRK10073 768492015672 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 768492015673 active site 768492015674 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 768492015675 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 768492015676 putative active site [active] 768492015677 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 768492015678 putative active site [active] 768492015679 putative catalytic site [active] 768492015680 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 768492015681 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 768492015682 putative active site [active] 768492015683 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768492015684 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 768492015685 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768492015686 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 768492015687 putative ADP-binding pocket [chemical binding]; other site 768492015688 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 768492015689 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 768492015690 putative active site [active] 768492015691 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 768492015692 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 768492015693 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 768492015694 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 768492015695 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 768492015696 putative metal binding site; other site 768492015697 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 768492015698 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 768492015699 active site 768492015700 (T/H)XGH motif; other site 768492015701 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 768492015702 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 768492015703 DNA binding site [nucleotide binding] 768492015704 catalytic residue [active] 768492015705 H2TH interface [polypeptide binding]; other site 768492015706 putative catalytic residues [active] 768492015707 turnover-facilitating residue; other site 768492015708 intercalation triad [nucleotide binding]; other site 768492015709 8OG recognition residue [nucleotide binding]; other site 768492015710 putative reading head residues; other site 768492015711 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 768492015712 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 768492015713 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 768492015714 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 768492015715 hypothetical protein; Reviewed; Region: PRK00024 768492015716 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 768492015717 MPN+ (JAMM) motif; other site 768492015718 Zinc-binding site [ion binding]; other site 768492015719 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 768492015720 Flavoprotein; Region: Flavoprotein; pfam02441 768492015721 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 768492015722 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 768492015723 trimer interface [polypeptide binding]; other site 768492015724 active site 768492015725 division inhibitor protein; Provisional; Region: slmA; PRK09480 768492015726 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768492015727 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768492015728 active site 768492015729 ribonuclease PH; Reviewed; Region: rph; PRK00173 768492015730 Ribonuclease PH; Region: RNase_PH_bact; cd11362 768492015731 hexamer interface [polypeptide binding]; other site 768492015732 active site 768492015733 hypothetical protein; Provisional; Region: PRK11820 768492015734 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 768492015735 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 768492015736 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 768492015737 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 768492015738 Nucleoside recognition; Region: Gate; pfam07670 768492015739 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 768492015740 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 768492015741 Predicted membrane protein [Function unknown]; Region: COG2860 768492015742 UPF0126 domain; Region: UPF0126; pfam03458 768492015743 UPF0126 domain; Region: UPF0126; pfam03458 768492015744 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768492015745 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768492015746 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 768492015747 putative effector binding pocket; other site 768492015748 putative dimerization interface [polypeptide binding]; other site 768492015749 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492015750 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768492015751 putative substrate translocation pore; other site 768492015752 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 768492015753 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 768492015754 catalytic site [active] 768492015755 G-X2-G-X-G-K; other site 768492015756 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 768492015757 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 768492015758 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768492015759 Zn2+ binding site [ion binding]; other site 768492015760 Mg2+ binding site [ion binding]; other site 768492015761 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 768492015762 synthetase active site [active] 768492015763 NTP binding site [chemical binding]; other site 768492015764 metal binding site [ion binding]; metal-binding site 768492015765 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 768492015766 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 768492015767 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 768492015768 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 768492015769 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 768492015770 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 768492015771 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 768492015772 generic binding surface II; other site 768492015773 ssDNA binding site; other site 768492015774 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768492015775 ATP binding site [chemical binding]; other site 768492015776 putative Mg++ binding site [ion binding]; other site 768492015777 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768492015778 nucleotide binding region [chemical binding]; other site 768492015779 ATP-binding site [chemical binding]; other site 768492015780 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 768492015781 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 768492015782 AsmA family; Region: AsmA; pfam05170 768492015783 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768492015784 Coenzyme A binding pocket [chemical binding]; other site 768492015785 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 768492015786 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 768492015787 putative active site [active] 768492015788 dimerization interface [polypeptide binding]; other site 768492015789 putative tRNAtyr binding site [nucleotide binding]; other site 768492015790 hypothetical protein; Reviewed; Region: PRK01637 768492015791 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 768492015792 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492015793 motif II; other site 768492015794 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 768492015795 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 768492015796 G1 box; other site 768492015797 putative GEF interaction site [polypeptide binding]; other site 768492015798 GTP/Mg2+ binding site [chemical binding]; other site 768492015799 Switch I region; other site 768492015800 G2 box; other site 768492015801 G3 box; other site 768492015802 Switch II region; other site 768492015803 G4 box; other site 768492015804 G5 box; other site 768492015805 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 768492015806 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 768492015807 glutamine synthetase; Provisional; Region: glnA; PRK09469 768492015808 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 768492015809 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 768492015810 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 768492015811 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768492015812 dimer interface [polypeptide binding]; other site 768492015813 phosphorylation site [posttranslational modification] 768492015814 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768492015815 ATP binding site [chemical binding]; other site 768492015816 Mg2+ binding site [ion binding]; other site 768492015817 G-X-G motif; other site 768492015818 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 768492015819 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768492015820 active site 768492015821 phosphorylation site [posttranslational modification] 768492015822 intermolecular recognition site; other site 768492015823 dimerization interface [polypeptide binding]; other site 768492015824 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492015825 Walker A motif; other site 768492015826 ATP binding site [chemical binding]; other site 768492015827 Walker B motif; other site 768492015828 arginine finger; other site 768492015829 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768492015830 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 768492015831 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768492015832 FeS/SAM binding site; other site 768492015833 HemN C-terminal domain; Region: HemN_C; pfam06969 768492015834 Der GTPase activator; Provisional; Region: PRK05244 768492015835 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 768492015836 G1 box; other site 768492015837 GTP/Mg2+ binding site [chemical binding]; other site 768492015838 Switch I region; other site 768492015839 G2 box; other site 768492015840 G3 box; other site 768492015841 Switch II region; other site 768492015842 G4 box; other site 768492015843 G5 box; other site 768492015844 DNA polymerase I; Provisional; Region: PRK05755 768492015845 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 768492015846 active site 768492015847 metal binding site 1 [ion binding]; metal-binding site 768492015848 putative 5' ssDNA interaction site; other site 768492015849 metal binding site 3; metal-binding site 768492015850 metal binding site 2 [ion binding]; metal-binding site 768492015851 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 768492015852 putative DNA binding site [nucleotide binding]; other site 768492015853 putative metal binding site [ion binding]; other site 768492015854 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 768492015855 active site 768492015856 catalytic site [active] 768492015857 substrate binding site [chemical binding]; other site 768492015858 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 768492015859 active site 768492015860 DNA binding site [nucleotide binding] 768492015861 catalytic site [active] 768492015862 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 768492015863 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 768492015864 putative acyl-acceptor binding pocket; other site 768492015865 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 768492015866 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 768492015867 catalytic residues [active] 768492015868 hinge region; other site 768492015869 alpha helical domain; other site 768492015870 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 768492015871 serine/threonine protein kinase; Provisional; Region: PRK11768 768492015872 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 768492015873 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 768492015874 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 768492015875 GTP binding site; other site 768492015876 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 768492015877 Walker A motif; other site 768492015878 Transcriptional regulators [Transcription]; Region: FadR; COG2186 768492015879 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768492015880 DNA-binding site [nucleotide binding]; DNA binding site 768492015881 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 768492015882 putative transporter; Provisional; Region: PRK10504 768492015883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768492015884 putative substrate translocation pore; other site 768492015885 transcriptional repressor RbsR; Provisional; Region: PRK10423 768492015886 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768492015887 DNA binding site [nucleotide binding] 768492015888 domain linker motif; other site 768492015889 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 768492015890 dimerization interface [polypeptide binding]; other site 768492015891 ligand binding site [chemical binding]; other site 768492015892 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768492015893 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 768492015894 substrate binding site [chemical binding]; other site 768492015895 dimer interface [polypeptide binding]; other site 768492015896 ATP binding site [chemical binding]; other site 768492015897 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 768492015898 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 768492015899 ligand binding site [chemical binding]; other site 768492015900 dimerization interface [polypeptide binding]; other site 768492015901 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768492015902 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768492015903 TM-ABC transporter signature motif; other site 768492015904 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 768492015905 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768492015906 Walker A/P-loop; other site 768492015907 ATP binding site [chemical binding]; other site 768492015908 Q-loop/lid; other site 768492015909 ABC transporter signature motif; other site 768492015910 Walker B; other site 768492015911 D-loop; other site 768492015912 H-loop/switch region; other site 768492015913 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768492015914 D-ribose pyranase; Provisional; Region: PRK11797 768492015915 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 768492015916 potassium uptake protein; Region: kup; TIGR00794 768492015917 regulatory ATPase RavA; Provisional; Region: PRK13531 768492015918 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768492015919 Walker A motif; other site 768492015920 ATP binding site [chemical binding]; other site 768492015921 Walker B motif; other site 768492015922 arginine finger; other site 768492015923 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 768492015924 hypothetical protein; Provisional; Region: yieM; PRK10997 768492015925 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 768492015926 metal ion-dependent adhesion site (MIDAS); other site 768492015927 Asparagine synthetase A [Amino acid transport and metabolism]; Region: AsnA; COG2502 768492015928 motif 1; other site 768492015929 dimer interface [polypeptide binding]; other site 768492015930 active site 768492015931 motif 2; other site 768492015932 motif 3; other site 768492015933 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 768492015934 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768492015935 dimerization interface [polypeptide binding]; other site 768492015936 putative DNA binding site [nucleotide binding]; other site 768492015937 putative Zn2+ binding site [ion binding]; other site 768492015938 AsnC family; Region: AsnC_trans_reg; pfam01037 768492015939 FMN-binding protein MioC; Provisional; Region: PRK09004 768492015940 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 768492015941 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 768492015942 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 768492015943 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 768492015944 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768492015945 S-adenosylmethionine binding site [chemical binding]; other site 768492015946 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 768492015947 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 768492015948 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 768492015949 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 768492015950 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 768492015951 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 768492015952 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 768492015953 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 768492015954 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 768492015955 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 768492015956 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 768492015957 beta subunit interaction interface [polypeptide binding]; other site 768492015958 Walker A motif; other site 768492015959 ATP binding site [chemical binding]; other site 768492015960 Walker B motif; other site 768492015961 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 768492015962 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 768492015963 core domain interface [polypeptide binding]; other site 768492015964 delta subunit interface [polypeptide binding]; other site 768492015965 epsilon subunit interface [polypeptide binding]; other site 768492015966 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 768492015967 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 768492015968 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 768492015969 alpha subunit interaction interface [polypeptide binding]; other site 768492015970 Walker A motif; other site 768492015971 ATP binding site [chemical binding]; other site 768492015972 Walker B motif; other site 768492015973 inhibitor binding site; inhibition site 768492015974 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 768492015975 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 768492015976 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 768492015977 gamma subunit interface [polypeptide binding]; other site 768492015978 epsilon subunit interface [polypeptide binding]; other site 768492015979 LBP interface [polypeptide binding]; other site 768492015980 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 768492015981 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 768492015982 Substrate binding site; other site 768492015983 Mg++ binding site; other site 768492015984 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 768492015985 active site 768492015986 substrate binding site [chemical binding]; other site 768492015987 CoA binding site [chemical binding]; other site 768492015988 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 768492015989 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 768492015990 glutaminase active site [active] 768492015991 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 768492015992 dimer interface [polypeptide binding]; other site 768492015993 active site 768492015994 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 768492015995 dimer interface [polypeptide binding]; other site 768492015996 active site 768492015997 AAA domain; Region: AAA_13; pfam13166 768492015998 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492015999 substrate binding pocket [chemical binding]; other site 768492016000 membrane-bound complex binding site; other site 768492016001 hinge residues; other site 768492016002 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 768492016003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492016004 dimer interface [polypeptide binding]; other site 768492016005 conserved gate region; other site 768492016006 putative PBP binding loops; other site 768492016007 ABC-ATPase subunit interface; other site 768492016008 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 768492016009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492016010 dimer interface [polypeptide binding]; other site 768492016011 conserved gate region; other site 768492016012 putative PBP binding loops; other site 768492016013 ABC-ATPase subunit interface; other site 768492016014 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 768492016015 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 768492016016 Walker A/P-loop; other site 768492016017 ATP binding site [chemical binding]; other site 768492016018 Q-loop/lid; other site 768492016019 ABC transporter signature motif; other site 768492016020 Walker B; other site 768492016021 D-loop; other site 768492016022 H-loop/switch region; other site 768492016023 transcriptional regulator PhoU; Provisional; Region: PRK11115 768492016024 PhoU domain; Region: PhoU; pfam01895 768492016025 PhoU domain; Region: PhoU; pfam01895 768492016026 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768492016027 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768492016028 substrate binding pocket [chemical binding]; other site 768492016029 membrane-bound complex binding site; other site 768492016030 hinge residues; other site 768492016031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492016032 dimer interface [polypeptide binding]; other site 768492016033 conserved gate region; other site 768492016034 putative PBP binding loops; other site 768492016035 ABC-ATPase subunit interface; other site 768492016036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768492016037 dimer interface [polypeptide binding]; other site 768492016038 conserved gate region; other site 768492016039 putative PBP binding loops; other site 768492016040 ABC-ATPase subunit interface; other site 768492016041 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 768492016042 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768492016043 motif II; other site 768492016044 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 768492016045 Predicted esterase [General function prediction only]; Region: COG0400 768492016046 Predicted flavoprotein [General function prediction only]; Region: COG0431 768492016047 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768492016048 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 768492016049 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 768492016050 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 768492016051 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 768492016052 trmE is a tRNA modification GTPase; Region: trmE; cd04164 768492016053 G1 box; other site 768492016054 GTP/Mg2+ binding site [chemical binding]; other site 768492016055 Switch I region; other site 768492016056 G2 box; other site 768492016057 Switch II region; other site 768492016058 G3 box; other site 768492016059 G4 box; other site 768492016060 G5 box; other site 768492016061 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 768492016062 membrane protein insertase; Provisional; Region: PRK01318 768492016063 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 768492016064 hypothetical protein; Validated; Region: PRK00041 768492016065 ribonuclease P; Reviewed; Region: rnpA; PRK01732 768492016066 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399